LOCUS       NZ_KQ947992            21086 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s009, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ947992
VERSION     NZ_KQ947992.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 395269)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 395269)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 105175
            Orig. end                         :: 126261
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ947992.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(294..473)
                     /locus_tag="AQI70_RS39685"
     CDS             complement(294..473)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS39685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_167358923.1"
                     /transl_table=11
                     /translation="MSAGPERLVRVALLSAVLAAVLILVVRPLLRRLLRPRAGRLRSSS
                     CRSSRRAPRRSPRC"
     gene            complement(747..980)
                     /locus_tag="AQI70_RS28655"
                     /old_locus_tag="AQI70_28655"
     CDS             complement(747..980)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQI70_28655"
                     /product="hypothetical protein"
                     /protein_id="WP_062155106.1"
                     /transl_table=11
                     /translation="MVFRLRGEADLPLDPEAPRQRLGRIMADARSRVCLTNLLAAAANR
                     PPDHPGAVRLCQSLDAETPKDVEETMQERHGR"
     gene            complement(1286..1513)
                     /locus_tag="AQI70_RS28660"
                     /old_locus_tag="AQI70_28660"
     CDS             complement(1286..1513)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123302.1"
                     /locus_tag="AQI70_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28660"
                     /product="MbtH family protein"
                     /protein_id="WP_062155108.1"
                     /transl_table=11
                     /translation="MSNPFEDADGTYFVLVNSEGQHSLWPSFAEIPAGWTTAFGEADRA
                     ACLAYVEESWTDMRPKSLVDAMGATDSTAQ"
     misc_feature    complement(1873..1891)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.01"
                     /tool="antismash"
     gene            2491..3306
                     /locus_tag="AQI70_RS28665"
                     /old_locus_tag="AQI70_28665"
     CDS             2491..3306
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="AQI70_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28665"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_062155110.1"
                     /transl_table=11
                     /translation="MCGRYAASRGPEDLAGIFEIEKWEPEETLEPDYNVAPTKEVHVVL
                     DRPLKDVEDPRPVRQLRKLKWGLVPSWSKTPESGFKMINARAETVHEKPSYRRAFGSRR
                     CIIPADGYYEWVTGKQERDLEVEGKRKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DEHPQAWWVTCSVITTEAETTPLAVAPAEGPNSLADIHPRMPLMLTPDRWDAWLDPSRT
                     DPEELRALLEPPPAGLMRAYPVSTLVSNVRNNGPELLKELEGPEEGTLF"
     misc_feature    2531..2546
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            3326..3955
                     /locus_tag="AQI70_RS28670"
                     /old_locus_tag="AQI70_28670"
     CDS             3326..3955
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998051.1"
                     /locus_tag="AQI70_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28670"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_062155507.1"
                     /transl_table=11
                     /translation="MTTEIIGTEAGDARITWHRAKKARLVLAVSHGAGGGIEARDLKAL
                     AEVLPAHGVTVARVEQPWRVAGKKVAPAPKTLDLGWRGLWPALAAPGLPVISGGRSAGA
                     RVACRTAVELGAHAVLALSFPLHPPGRPEKSRAGELLGAGVPTLVVQGGNDPFGKPEEF
                     PDGDHGIVEVPYADHGFAVPKRAPLGQDEAVAVITDAVVKWTGSLG"
     gene            4213..4908
                     /locus_tag="AQI70_RS28675"
                     /old_locus_tag="AQI70_28675"
     CDS             4213..4908
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="AQI70_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28675"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_003998050.1"
                     /transl_table=11
                     /translation="MGPVPGTDAGTDNGQAEQPEGLGTSVDTSTETTAERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGD
                     SNEAKGSGS"
     gene            4905..5207
                     /gene="rsrA"
                     /locus_tag="AQI70_RS28680"
                     /old_locus_tag="AQI70_28680"
     CDS             4905..5207
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="AQI70_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28680"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_003998049.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFKQHFRECSPCL
                     EKYGLEEAVKKLVKRCCGHDDVPTDLRAKVMGRIELIRSGQAVPDHDVTATPQES"
     misc_feature    complement(5257..5269)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.49"
                     /tool="antismash"
     gene            5337..6644
                     /locus_tag="AQI70_RS28685"
                     /old_locus_tag="AQI70_28685"
     CDS             5337..6644
                     /EC_number="3.1.4.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491202.1"
                     /locus_tag="AQI70_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28685"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_062155112.1"
                     /transl_table=11
                     /translation="MEAIPARARVYVAGVALCALGCLLPLTTTHTPWWAAVLLAALYAA
                     GEQVAARWWFAGTFYPVLLAGAFLLPPSAAALVAVPGALLAPAGQRPRWTRRIWRAAQL
                     AVAVWATARVHWALGGREAVGAGDLPGALLPAGGAVLAFCAVLTALDGGMSALAERSPV
                     RRAWRGLFARSLAPIAVHGLAGLMMAVLWCSPYGPVAALLVLLPMCVSWWVFAQYHRER
                     AAHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMDDERIEVLRFAGILHDVG
                     KLGVPTRLLRKNGPLTPEERRVIELHPEYGHEMVRGISFLGEARAAVLHHHERLDGSGY
                     PYGLAGSQIPESARVVAVADAFDAMTSNRCYSRARPVSVALGELEKCAGSHFDPRMVTA
                     LARAVDQYGWHPAVTADDAAAPPARPPVSSAPGAHR"
     gene            6641..7894
                     /locus_tag="AQI70_RS28690"
                     /old_locus_tag="AQI70_28690"
     CDS             6641..7894
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998047.1"
                     /locus_tag="AQI70_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28690"
                     /product="HD domain-containing protein"
                     /protein_id="WP_062155114.1"
                     /transl_table=11
                     /translation="MSGPRAPGRPPLLLTLVHTCAALLAAVCLLGTLWHGLDERGVALA
                     FGVLVTVGELTRWTGAEGREAAPLGAAAALSYALLGEDGGDPTHHGVLQVVTVVLAASL
                     LGSVPHIARGRPVADHLARRVFTVGFAAVCFQPLYNQGTFHGWGSAYALLLLAILVLTA
                     LCDALLAAALAHSRTRWPFGPLLRDELRATLGIGSAVCATGAVMALAVAVVGLWALPVF
                     SLPLLLTQMSFRRYAAVRTTYRQTIASLARATEIAGYTPTGHARRVAALSREVGRDLGL
                     TEAELTVLEYAALMHDIGQLSLVDPVPAGATAALPVEEQRRIALLGGAVVRQTGVNPQV
                     ATVVERLADPCPEQPVAARIVRAVNAYEEKTRDAGPGGPLKALEELRLGTAGDYAPEVV
                     ESLARVLSRDGLTLPVAG"
     gene            8003..8983
                     /locus_tag="AQI70_RS28695"
                     /old_locus_tag="AQI70_28695"
     CDS             8003..8983
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="AQI70_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28695"
                     /product="hypothetical protein"
                     /protein_id="WP_062155116.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRVPGGATDSGEPVGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSSGHAYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9057..9707
                     /gene="def"
                     /locus_tag="AQI70_RS28700"
                     /old_locus_tag="AQI70_28700"
     CDS             9057..9707
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="AQI70_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28700"
                     /product="peptide deformylase"
                     /protein_id="WP_062155118.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDDGFVIDTEDCEEREQAYRERGTSRPIT
                     VVGNPVLHKECKDVTEFDDELLKLVDDMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD
                     QGVRHVGVVCNPKLVDLPADKRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDERGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND"
     misc_feature    9721..9735
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.7"
                     /tool="antismash"
     misc_feature    9748..9766
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.57"
                     /tool="antismash"
     misc_feature    9822..9835
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            10001..11086
                     /gene="cyc1"
                     /locus_tag="AQI70_RS28705"
                     /old_locus_tag="AQI70_28705"
     CDS             10001..11086
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="AQI70_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28705"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_107117109.1"
                     /sec_met_domain="T1TS (E-value: 8.3e-65, bitscore: 214.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFSHSTTSTPTAVPVPPSLALPVIEAAFPRQLHPYWPRLQEKT
                     RTWLLEKRLMPADKVEEYADGLCYTDLMAGYYIGAPDEVLQAIGDYSAWFFVWDDRHDR
                     DIVHHRPAAWRRLRFRLHAALDSPEEHLHHDDPLVAGFADSMVRLYSFLPRTWNIRFAR
                     HFHAVIEAYDREFRNRTEGNIPTVEEYLALRRLTFAHWIWTDLLEPSAGLELPEHVRKH
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLIKDKGLPLEEAVKEVRRRVE
                     TCISDFLVAEREALELADSLADGTLRGKELSAAVRACVSNMRNWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVNNEAAGEK"
     gene            11083..12468
                     /locus_tag="AQI70_RS28710"
                     /old_locus_tag="AQI70_28710"
     CDS             11083..12468
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674897.1"
                     /locus_tag="AQI70_RS28710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28710"
                     /product="cytochrome P450"
                     /protein_id="WP_062155122.1"
                     /sec_met_domain="p450 (E-value: 3.5e-72, bitscore: 238.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVKPGAPVAAASQGELREPPLAGGGVPLLGHGWKLVRDPLA
                     FMAGLREHGDVVRLRLGPKTVYAVTTPELTGALALSTDFKIDGPLWESLEGLLGKEGVA
                     TANGPRHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWKPGETVDCTSESFRIAVR
                     IAARCLLRGDYMDERAERLCVALATVFRGMYRRMVIPLGPLYNLPLPPNREFNRALADL
                     HLLVDEIVAERRASGQKPDDLLTALLEAKDENGDPIGEQEIHDQVVAIVTPGSETVAST
                     IMWLLHVLAEHPEHAARVRAEVESVTGGRPVAFEDVRALRHTNNVVVEAMRLRPAVWIL
                     TRRAVTDTSLGGYRIPAGADIIYSPYAIQRDPKSYAHNLEFDPDRWLPERVKEVPKYAM
                     SPFSVGNRKCPSDHFSMAQLTLITAALSSKYRFEQVSGSNDATRVGITLRPHDLLLKPV
                     PWE"
     gene            complement(12470..13435)
                     /locus_tag="AQI70_RS28715"
                     /old_locus_tag="AQI70_28715"
     CDS             complement(12470..13435)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998042.1"
                     /locus_tag="AQI70_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28715"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_062155124.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLDGVHPFELGVVCEVFGIDRSDDGLPTYDFAVVSAE
                     GPTLATHVGGLTLSTPYGLERLAEADLITVPAGNDYVTRDYPPELLDCLVSAVERGARV
                     LSVCSGAFVLGAAGLLDGRRCSVHWRHAAELSLRHPRAIVEPDVLYVDEGPVITSAGTA
                     AGIDACLHIVRQEQGPEVANKIARRMVVPPHRDGGQAQYIERPLPRSQCDTVGEVLAWM
                     ERHLDEEVTVEQLAERAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQELLEATDETV
                     DAIAGRTGFGTAAALRHQFVRALGTTPNAYRRTFRGSEAA"
     gene            complement(13695..14708)
                     /locus_tag="AQI70_RS28720"
                     /old_locus_tag="AQI70_28720"
     CDS             complement(13695..14708)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="AQI70_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28720"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_003998041.1"
                     /transl_table=11
                     /translation="MTTRNQNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLTPAEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPEDRAAAFAAVENIPSIREKAEFCFKWMDSVEKLDRLESKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPELFDDQLQQQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14708..17086)
                     /locus_tag="AQI70_RS28725"
                     /old_locus_tag="AQI70_28725"
     CDS             complement(14708..17086)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657909.1"
                     /locus_tag="AQI70_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28725"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_062155126.1"
                     /transl_table=11
                     /translation="MTIAPADPASAALVDTDGPGAALLRTLTELTADLPDADPGRVAAA
                     ALRGRSARAASEITAELRELATEAAAGLISEDPAYSRLAARLLTISIAAEAASQGVTSF
                     TESVAVGHREGLIADRTAEFVRVHAARLDALIDTGADDRFGYFGLRTLHSRYLLRHPLT
                     RKVIETPQHFMLRVAAGLAEDDTAGSVDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQM
                     SSCYLLDSPKDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVP
                     FLTTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWV
                     PDEFMRRVNADGQWSLFSPADVPELVDLWGEEFDAAYRKAEEAGLARKTIPARDLYGRM
                     MRTLAQTGNGWMTFKDAANRTANQTALPGHVVHSSNLCTEILEVTDDGETAVCNLGSVN
                     LGAFVDPTRQDIDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGL
                     QDVFFKLRLPFDSAEAKRLSTRIAERIMLAAYEASADLAERGGPLPAWEKTRTARGVLH
                     PDHYDVELTWPERWAALRSRIATTGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFK
                     RETLSGEFLQVNSYLVNDLKELGVWDARTREALRDSGGSVQDFAWIPADVRALYRTAWE
                     IPQRGLIDMAAARTPFLDQSQSLNLFMETPTIGKLSSMYAYAWKQGLKTTYYLRSRPAT
                     RIARAAQAQAQATIPVQQPAPEDAVACSLENPESCEACQ"
     regulatory      complement(17208..17382)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17345..17359)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17376..17390)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17401..17907)
                     /locus_tag="AQI70_RS28730"
                     /old_locus_tag="AQI70_28730"
     CDS             complement(17401..17907)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="AQI70_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28730"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_062155128.1"
                     /transl_table=11
                     /translation="MDIVIRQVEPDEYEALGEITAQAYLQDGLLDFGESDEYLGELKDV
                     AKRAAAAEVLVAVHSGRVVGGVTFVPSGGPMADIAGPGEAEIRMLAVSREARGRGAGEA
                     LVRACVERARATDGCVRIVLSSQRTMHSAHRIYERLGFVRTPERDWNPIPHLSDITLLT
                     YELTL"
     gene            complement(17980..19590)
                     /locus_tag="AQI70_RS28735"
                     /old_locus_tag="AQI70_28735"
     CDS             complement(17980..19590)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444565.1"
                     /locus_tag="AQI70_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28735"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_062155130.1"
                     /transl_table=11
                     /translation="MNGGVNGVALGVFIFFFLAVTVMGFLAARWRKAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGLLATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFTAASEKYTKAGAGGLIPPEAGQWTYATLALGSALALFMYPHSITATLSSRSREV
                     IRRNTTILPLYSLMLGLLALLGFMAIAAGVSVTNPQLAIPQLFEDMFPSWFAGVAFAAI
                     GIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKLVSLLVKVGALVFVLTM
                     DKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTVAAYGVASPT
                     QKHFGGSAKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLKAAKAPEGVDETRPEDYTAD
                     AGDPGVQVELPPATAGSSH"
     gene            complement(19587..19850)
                     /locus_tag="AQI70_RS28740"
                     /old_locus_tag="AQI70_28740"
     CDS             complement(19587..19850)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992859.1"
                     /locus_tag="AQI70_RS28740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28740"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_079051525.1"
                     /transl_table=11
                     /translation="MSDAPEVNRAVVTPIRVVIALCLGAPFVAMLWVGSYAKTDPEFAG
                     IPFFYWYQMLWVLLSTLLTMVAYKLWQRDQRARASQKGGAAE"
     gene            complement(19979..20176)
                     /locus_tag="AQI70_RS28745"
                     /old_locus_tag="AQI70_28745"
     CDS             complement(19979..20176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657905.1"
                     /locus_tag="AQI70_RS28745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_28745"
                     /product="YbdD/YjiX family protein"
                     /protein_id="WP_062155134.1"
                     /transl_table=11
                     /translation="MRSLRRVLRGVRWYVRELTDESAYDRYVAHLRREHPDARVPSRRD
                     FERMRTDRQEQDPRQGFRCC"
     misc_feature    20521..20536
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
ORIGIN
        1 gtgaccaggg tggcgatcac cacccacaca tcggggtcgg gctgggtgcc ggagacctcg
       61 ttccagaggg aggcgagcga ggcggatgcg gtgctgtcca tgtaaggcga tggctccctg
      121 gggtcggatg gaatctggca gtgtggcacg tccgcacgga ctgtctctga gacgtccacg
      181 tggcaccgat cgttcctgac cgcagggtgg gggtcaccgc gtgggagccc ccgagtgttg
      241 cggggcggct cccgccgagg cgtcggccgg gtggccctct cggaagacgg gcatcagcaa
      301 cgcggtgatc ttcttggcgc ccgccgcgag gaccggcagg acgagctccg gagccgtccc
      361 gcgcgggggc gcagcagccg ccgcagcagc ggacgtacga cgaggatcag caccgcggcg
      421 aggaccgcgc tgagcagggc gacccggacc agccgctccg gaccggccga caccgcgacg
      481 accgagacga cgatgagcgt gcggcttgcg ccggggggcg tggcccatcc ggtcgtactc
      541 ggcgaccagg accttctcga tggccacgca gtgcggcagc actactgccc ggcctcgtag
      601 cggaactgcg ggtcgaggat ctcctcacgg agcatctgga ccgggccgcc ggagatgcgg
      661 ccggtcagtg cgctctccat taggcggtca gcccgagccg caggttcctg aagtctgcgt
      721 gccgccacaa actggttctt tctcggtcac cgaccgtgcc tttcctgcat cgtttcctcc
      781 acgtccttcg gtgtctccgc gtcgaggctc tggcagaggc gcaccgcccc gggatggtcc
      841 ggtggccggt tggccgcggc ggccagcagg ttggtaaggc acacccggga gcgggcgtcg
      901 gccatgatcc ggccgaggcg ctgccggggc gcctccggat cgagcggaag gtcggcctcg
      961 ccgcgcaggc ggaacaccat cggctcgttg tagacggcga ggtcaccggt gagctggtcc
     1021 agccgccgga gccgttcctc ggcgtgcgac ggctcgccgg gccgccccgg ggcgggctcg
     1081 atcgccgccg caccggagcc gccgggggca tcggaggcaa cgggagagat gccgagaatc
     1141 tcgccgaagg ctcttatgag cgcggaaaca ggccggcgaa gcagttcttg gcgagcgact
     1201 cactgggcgt caggtcggac atgaagtgct ccattccatc tgcgaattgc cgggcatctt
     1261 cgatcgccgc gagatgagcg cagggctatt gggcggtcga gtccgtcgcg cccatcgcgt
     1321 ccacgaggct cttcggccgc atgtcggtcc acgactcctc gacgtacgcc aggcatgccg
     1381 cgcggtcggc ctcgccgaag gcggtcgtcc agccggccgg gatctcggcg aaggagggcc
     1441 acagggagtg ctggccctcg gagttgacca ggacgaagta ggtgccgtcc gcgtcttcga
     1501 aggggttgct cacagctgaa agtgcctttc tgtgtggatt cacgcccgca caggtctgtc
     1561 cgggaaggtg aaccggatgt gcggcgggat catggcgtct tcgatcgtgc gcggcgccgg
     1621 gcgcgggatg gcccccggac cgccgggtgt ccgggcggtc gggcctgcgg gaaatcatgg
     1681 gtgtcggcgg ggtcggcacc gagaaaagtc acgagaacgg ctgccgacgg tgaaagggac
     1741 gtggcaagag gccggcatgc cgtcagcggc aatgcgtccc ccgcgccgtc tatggcctgc
     1801 gtgagtctgg gtcccccgac atgtttttcg tatcccccga aaccgattcc ttgtccccgg
     1861 caagcggcgt ccggtgagag tcgttcgcgc cgactcctgc gctgccgccc cctgcggcgc
     1921 ttcccgccgc gaaaacgcag tcggtcggga aagggattaa gagggacatc atgtgtccaa
     1981 tgcttccttt cggcgctttt ccgggactgc cgttgtgagg gtaacagttc cgtcaatcgc
     2041 cattgtggta gatcatcaat gtccgtgacc tcctgataag gagggggctt aacgggattg
     2101 tgggcaatga atcgggcatg atcgacgacc gcgagtgtcg gaggaactgg gcctggttca
     2161 gaagggacag gagcagtcgc cgtcgccggt ggccgtggcc ccggagcggg ccgttcgacg
     2221 cggccgacgt cgcggaacag ctgaaacggc gggtcgtcct gctgctcacg actggggtcc
     2281 gagagccggt tccaggcggg ctgcctgctc gccgtccatc aggcggccgg cacagggccg
     2341 ttcgcagcac cgcagtgagg cggtgagccg ccccttccga tgcctggcgg cggcaccggt
     2401 ctgccaacct tggacgtgtt cagtcagcac cgtggtgctg accgagacgg catgatctag
     2461 cgtttccgca ggtcggaggg gtggcttcat atgtgcggac ggtatgcggc gagtcgtgga
     2521 cccgaggatc tcgcaggcat cttcgagatc gagaagtggg agccggagga gaccctggag
     2581 ccggactaca acgtggctcc gacgaaggag gtccacgtcg ttctcgaccg tccgctgaag
     2641 gacgtggagg accctcggcc ggttcggcag ctgcggaagc tgaagtgggg gctggtgccc
     2701 agctggtcca agacccccga gagcggcttc aagatgatca acgcacgggc ggagacggtg
     2761 cacgagaagc cgtcgtaccg cagggccttc ggctcccggc gctgcatcat ccccgccgac
     2821 ggctactacg agtgggtgac cggcaagcag gagcgggacc tggaggtcga ggggaagcgc
     2881 aaacggccgc gcaagcagcc gtacttcgtg ctgcccgccg acgggtcggt gttcgcgatg
     2941 gccgggctct acgagttctg gcgggaccgg acgctgcccg acgagcatcc ccaggcctgg
     3001 tgggtgacct gttccgtcat cacgacggag gcggagacga ccccgctggc cgtggcgccc
     3061 gccgagggcc cgaactcgct ggccgacatc cacccccgga tgccgctgat gctgaccccg
     3121 gaccgctggg acgcctggct ggacccgtcc cgcaccgacc cggaggagct gcgggcgctg
     3181 ctcgaaccgc cgccggccgg actgatgcgc gcctaccccg tctccaccct ggtcagcaac
     3241 gtccgcaaca acggcccgga gctgctgaag gaactggagg gccccgaaga gggcacactc
     3301 ttctgatgtg acgaccgagt ctgatgtgac caccgagatc attggtaccg aggcggggga
     3361 cgcccgcatc acctggcacc gggcgaagaa ggcacggctg gtcctggccg tgagccacgg
     3421 cgcgggaggc ggcatcgagg cccgggacct caaggcgctc gccgaggtcc tgccggccca
     3481 cggtgtgacg gtcgcccgcg tggagcagcc ctggcgggtg gccggcaaga aggtggcgcc
     3541 cgcgcccaag accctcgacc tcgggtggcg gggactgtgg cccgccctag ccgcgcccgg
     3601 actgccggtg atctccggcg gccgcagcgc cggggcccgg gtcgcctgcc gtacggccgt
     3661 ggaactcggg gcgcacgccg tactcgccct cagcttcccg ctgcatcccc cgggcaggcc
     3721 cgagaagtcc cgcgccggcg aactgctcgg ggccggggtg cccacgctcg tcgtacaggg
     3781 cgggaacgac ccgttcggga agccggagga gttcccggac ggcgaccacg ggatcgtcga
     3841 ggtgccgtac gccgatcacg ggttcgccgt gcccaagcgg gcgcccctcg ggcaggacga
     3901 ggccgtggcg gtcatcaccg acgcggtcgt gaagtggacc gggtcactcg ggtaaagctt
     3961 cgggaatgtc ggggccccgc tctctgttgt cgcggaaagc ggtgctgaac caccagcgcc
     4021 gacgtcgtag gagaggaagt ccgccgcatg ggttcgacct tctgcccggc ccgcagcagc
     4081 cgcagtgacc tggactggac ggtgctgcac gcggccagga ccgctcctat tcgaggggcg
     4141 gcaggtacgg caggtcgtct atcctccgat tcaggtggga ccggtttcgg tcctgcccgc
     4201 aatcttgagg aggtgggtcc ggttcccggt accgacgcag ggaccgacaa cggccaggcg
     4261 gagcagcccg agggtctggg cacgagcgtg gacacgtcca cggagacgac cgccgagcgc
     4321 agcgcgcgct tcgagcggga cgcactcgaa ttcctcgacc agatgtactc ggccgcgctg
     4381 cgcatgacgc gcaacccggc cgacgccgag gacctggtgc aggagacgta cgccaaggcg
     4441 tacgcgtcct tccaccagtt ccgtgaaggc accaacctca aggcgtggct gtaccggatc
     4501 ctcaccaaca ccttcatcaa ctcctaccgc aagaagcagc gtgaacccca gcgcagcgcg
     4561 gccgaggaga tcgaggactg gcagctcgcc cgcgccgagt cgcacatgtc gacgggtctg
     4621 cgctccgcgg agtcgcaggc gctcgaccac ctgcccgact cggacgtgaa ggaagcgctc
     4681 caggcgatcc ccgaggaatt ccgcatcgcc gtgtacctcg ccgacgtaga gggctttgcg
     4741 tacaaggaga tcgcggacat catggggaca cccatcggta cggtgatgtc ccggctgcac
     4801 cggggccgcc gtcaactgcg cggcatgctc gaggactacg cccgtgagcg cgggctggtc
     4861 ccggccggcg ccggagactc gaacgaagcg aaaggctcgg gctcatgagc tgcggagagc
     4921 cgcacgagac ggactgcagt gaggtcctgg accatctgta cgagtttctc gacagtgaga
     4981 tgccggacgt cgatcgcgac aagttcaagc agcacttccg cgagtgctcg ccgtgcctgg
     5041 agaagtacgg cctcgaagag gccgtgaaga agctggtcaa gcgctgctgc gggcatgacg
     5101 acgtgccgac ggacctgcgt gccaaggtca tggggcggat cgagctgatc cgctccggcc
     5161 aggccgtgcc cgaccacgac gtgaccgcca ccccgcagga gtcctgaact cctctccggg
     5221 aacgggctgt cgtcacccga acgtgctaat cggcgcgtga caaggccaca gttgccccct
     5281 ttgccgacct aggctccgtt gagctgaaca ggtcatggcg gaggagggcg tcggagatgg
     5341 aggcgatacc ggcacgggca cgtgtctacg tcgccggtgt ggcgctgtgc gccctgggct
     5401 gcctccttcc gctgaccacc actcacacgc cctggtgggc ggccgttctg ctcgccgcgc
     5461 tgtatgccgc cggtgagcag gtcgccgccc ggtggtggtt cgcgggcacc ttctaccccg
     5521 ttctgctcgc cggggccttc ctgctgccgc cgtccgccgc cgcgctggtc gcggtgccgg
     5581 gcgcgctgct ggcgccggcc gggcaacggc cgcgctggac ccggcggatc tggcgggccg
     5641 cccagctcgc ggtggccgtc tgggcgacgg cccgggtgca ctgggcgctg ggcgggcgcg
     5701 aggccgtcgg ggcgggcgac ctgccgggcg cgctgctgcc ggccggcggt gcggtgctgg
     5761 cgttctgtgc ggtgctgacc gcgctggacg gaggcatgtc ggcgctcgcc gagcgctcgc
     5821 cggtgcggcg cgcctggcgg gggctgttcg cccggtcgct cgcacccatc gccgtgcacg
     5881 gtctggccgg gctcatgatg gccgtgctgt ggtgcagtcc gtacggcccc gtcgccgcgc
     5941 tgctcgtgct gctgccgatg tgtgtgtcgt ggtgggtgtt cgcccagtac caccgggaac
     6001 gagcggctca ccaggcgacc atccgggcgc tcgtccaggc cgtcgacatc aaggacggct
     6061 acacccgcgg gcacagcgag cgggtcgggc aggcctcgat gatgatcgcg cgtgagctgg
     6121 gcatggacga cgagcgcatc gaggtgctgc ggttcgccgg gatcctgcac gacgtgggga
     6181 agctcggcgt gcccacccgg ctgctgcgca agaacgggcc gctcaccccc gaggagcggc
     6241 gggtgatcga actgcatccc gagtacggcc atgagatggt ccggggcatc tcctttctcg
     6301 gggaggcgcg ggccgccgta ctgcaccacc atgagcggct ggacgggagc gggtacccct
     6361 acgggctggc cggcagccag atcccggagt cggcgcgggt ggtggcggtc gcggacgcgt
     6421 tcgacgcgat gacgtcgaac cggtgctatt cgagggcccg gcccgtctcc gtggccctcg
     6481 gggagctgga gaagtgcgcg gggtcgcact tcgacccgcg gatggtgacc gccctcgccc
     6541 gggccgtgga ccagtacggg tggcatcccg ccgtgaccgc cgacgacgcg gctgcgcccc
     6601 ctgcccgccc gccggtctcc agcgccccgg gagcgcaccg atgagcggcc cgcgtgcccc
     6661 cggccgacca ccccttctcc ttaccctcgt ccacacctgc gccgccctcc tggccgccgt
     6721 ctgcctgctc ggcaccctct ggcacggcct cgacgaacgc ggtgtcgccc tcgccttcgg
     6781 ggtcctcgtc accgtggggg aactgacccg gtggaccggc gcggaagggc gggaggccgc
     6841 gccgctcggt gccgccgcgg cgctgtcgta cgccctgctg ggggaggacg gcggagaccc
     6901 cacccaccac ggcgtcctcc aggtcgtcac cgtcgtcctg gccgcctcgc tcctcggcag
     6961 cgtgccgcac atcgcgcggg gccgccccgt ggccgaccat ctcgcccggc gcgtgttcac
     7021 cgtcggcttc gccgccgtct gcttccagcc cctgtacaac cagggcacct tccacggctg
     7081 gggttccgcc tacgccctgc tcctgctcgc gatcctcgtc ctcaccgccc tgtgcgacgc
     7141 cctgctcgcc gccgcgctgg cgcactccag gacccggtgg ccgttcgggc cgctgctgcg
     7201 ggacgagctg cgggccaccc tcgggatcgg gtcggccgtc tgcgcgaccg gcgcggtgat
     7261 ggccctcgcg gtcgccgtgg tcgggctgtg ggcgctgccc gtcttctcgc tgcccctgct
     7321 gctcacccag atgtccttcc gccggtacgc cgccgtccgg accacctacc ggcagaccat
     7381 cgcctccctc gcccgcgcca ccgagatcgc cgggtacacc ccgaccggac acgcccggcg
     7441 ggtggcggcg ctcagccggg aggtcggccg ggacctgggc ctcaccgagg ccgaactcac
     7501 cgtgctggag tacgcggccc tcatgcacga catcgggcag ctgagcctgg tcgacccggt
     7561 gccggccggg gccacggccg cgctgcccgt cgaggagcag cggcggatcg cgctgctcgg
     7621 cggggccgtc gtacggcaga ccggggtgaa cccgcaggtg gcgacggttg tggagcggct
     7681 ggccgacccc tgcccggagc agccggtcgc cgcgcggatc gtgcgggcgg tgaacgccta
     7741 cgaggagaag acacgggacg ccgggccggg cgggccgctg aaggcgctgg aggagctgcg
     7801 gctgggcacc gccggagatt acgcgcccga ggtggtggaa tcgctcgcac gggtactgtc
     7861 cagagacggt ctgactttgc ctgtggcggg gtaacccatg ggtaatgagc gcccttccag
     7921 ccgtacgtgg ttggatgcga atgagagggt gtccgggggc agcactagcc agcccactcc
     7981 acggaactgg caggcgggaa tcgtgaggat cttcggcaag ggacggcacc ggccctccgc
     8041 ctcctggcgg caggccaccg accgcgcgtt cacactgatc ggcgacggcc ggtacgagga
     8101 cgcgggcgcg ctgctgacgc gggccgccga tctggagccc tggctttccg agtcctggtt
     8161 caacctcgcc ctgctgcaca agttccggca cgactgggag caggcccggg ccgccggact
     8221 gcgcgccgtg gcgctgctcg accgggagac cggggcaccc gactggtgga acgtcggtat
     8281 cgccgccacc gccctgcagg actggccgct ggcccgtcgg gcctggcagg cctacgggct
     8341 gcgggtgccc ggcggtgcca ccgactccgg cgagccggtc ggcatggacc tgggcagcgc
     8401 ggccgtacga ctgtcccccg agggggaggc cgaggtcgtg tgggggcgcc ggctggaccc
     8461 cgcccggatc gaggtgctgt ccatcccgct gccgtcctcc gggcggcgct ggggcgaggt
     8521 cgtgctgcac gacggggtgc cccacgggga gcggaccacg tcctccgggc acgcctaccc
     8581 ggtcttcgac gagatcgagc tgtgggcgcc ctcgccggtt ccgacgtggg tggtgctcct
     8641 ggaggccgcc accgaggccg accgggacgc cctggagcag ctcgccgcgg acgccgggtt
     8701 cgccgcggag gactggtcgt cgtccgtacg gctgctgtgc cggatgtgct ccgagtcacg
     8761 gatgccgtcc gacgagggcg acggggagca cctggacccg cacgaccaca gtgaaccggg
     8821 tcatcccggg ccgctggggc accgcaccga cgggcagctg tgggtgccgg agcgggagtg
     8881 cggcgtcgcg gcgcccgcct cactcgtgcg gggactgctg gacgggtggg tcgcggacag
     8941 cccggactcc cgggactggc gggatctcga agaggtctgc tgagcgttcg ccgtaccctg
     9001 tatcagcgtc acacccccct ttgttctttg tttgtgcagg aaggcatacg tcggtcatgg
     9061 cccagcagga caccgatcag cagcacgcgg gcgtgctccc cgtcgacgac gacgggttcg
     9121 tcatcgacac ggaggactgc gaggagcgcg agcaggcgta ccgcgagcgt ggcacctcgc
     9181 ggcccatcac ggtcgtcggg aacccggtgc tccacaagga gtgcaaggac gtcaccgagt
     9241 tcgacgacga gctgctgaag ctggtcgacg acatgttcgc cagccagcgc accgccgagg
     9301 gcgtgggcct ggccgccaac cagatcggtg tcgatctgaa ggtcttcgtc tacgactgcc
     9361 aggacgacca gggcgtccgg cacgtcggcg tggtctgcaa cccgaagctc gtcgacctgc
     9421 cggccgacaa gcgccgcctg gacgacagca acgagggctg cctctcggtg ccgacggcat
     9481 atgcgccgct ggcccgcccg gactacgccg aggtgaccgg gcaggacgag cggggcaacc
     9541 ccatcaaggt gcgcggcacc gggtacttcg ctcggtgttt gcagcacgag accgaccacc
     9601 tgtacggcta cctctacatc gaccgcctct ccaagcggga gcgcaaggac gcgctgaggc
     9661 agatggccga gaacgagccc cgctaccccg tggtcgcgaa cgactgaggc ctccgcccca
     9721 aggcccaccg gccccacccg cacggcgtct gttcaggttc accttcctga ccaggcgccg
     9781 ttcgcatgtc cgtcgcacgt tcgatcccat acacgcaggt ggtgatccag atccagtcac
     9841 atagggggag attctcggca ctgtggggta gtgaatgaag caaatccgtt cccagaacgg
     9901 tcagttgtag tgctgaatgg gaggggcggg gatacgcaac ggcgcacgcc cggcacagcg
     9961 ggaggggcgt gttcaactgg cggctgagag gggtttgttc gtgcatgctt tctcacacag
    10021 caccacatcc acaccgacgg cggtgccagt tccaccatcg ctcgctcttc cggtgatcga
    10081 agcagcgttt cccaggcaac tccatccgta ttggcccagg ctccaggaga agacacgcac
    10141 ctggctgctg gaaaaacggc tgatgccggc cgacaaggtc gaggaatatg ccgacggcct
    10201 ttgctacacc gacctgatgg cggggtacta cattggcgct cccgacgagg tcctccaggc
    10261 gatcggggac tacagcgcgt ggttcttcgt ctgggacgac cggcacgacc gcgacatcgt
    10321 ccaccaccga ccggccgcct ggcggcgcct gaggttccgc ctgcacgcgg cactcgactc
    10381 ccccgaggag catctgcacc acgacgaccc gctggtcgcc gggttcgcgg acagcatggt
    10441 gcggttgtac tcgttcctgc cccgcacctg gaacatccgc ttcgcccggc acttccacgc
    10501 ggtgatcgag gcgtacgacc gggaattccg caaccgcacc gaggggaaca tacccacggt
    10561 ggaggaatac ctcgcactgc gtcggctcac gttcgcgcac tggatctgga ccgatctgct
    10621 ggagccgagt gcggggctgg aactgccgga gcacgttcgg aaacacccgg catatcggcg
    10681 ggccgcgttg ttgagccagg aattcgccgc ctggtacaac gatctctgct cgctccccaa
    10741 ggaaatcgca ggcgatgagg tccacaatct cggaatcagt ctcatcaaag acaaggggct
    10801 gcccctggaa gaggctgtga aggaagtcag gcgacgggtc gagacctgta tatccgattt
    10861 cctggtggcg gagcgggaag ccctggaact cgccgactcc ctggccgacg gaacgctgcg
    10921 gggaaaggaa ctcagcgccg ccgtacgcgc ctgcgtcagc aatatgcgca actggttcag
    10981 ctcggtctac tggttccacc acgagtccgg ccggtacatg gtcgacagct gggacgaccg
    11041 gtccacgccc ccgtacgtca acaacgaagc ggcaggtgag aaatgaccgt cgagtctgtg
    11101 aagcccggag ccccggtcgc tgcggcgtcc cagggagagc tgcgtgagcc gcccctcgcg
    11161 ggcggcggag ttccgcttct cggtcacggc tggaagctgg tccgagatcc gctggccttc
    11221 atggccgggc tccgggagca cggcgacgtc gtacggctga ggctcggccc gaagacggtg
    11281 tacgccgtca ccacgccgga gctcaccggc gccctggcgc tgagcaccga cttcaagatc
    11341 gacgggccgc tgtgggagtc cctggaaggc ctgctcggca aggagggtgt ggccaccgcc
    11401 aacggcccac ggcaccggcg tcagcggcgc accatccagc ccgccttccg gctggacgcg
    11461 atccccgcgt acgggccgat catggaggag gaggcgcatg cgctgaccga gcgctggaag
    11521 cccggcgaga ccgtcgactg cacctccgag tccttccgga tcgccgtgcg gatcgcggcc
    11581 cgctgtctgc tgcgcggcga ctacatggac gagcgggccg agcggctgtg cgtcgcgctc
    11641 gccaccgtct tccggggcat gtaccggcgg atggtgatcc cgctcgggcc gctgtacaac
    11701 ctgcctctcc cgcccaaccg cgaattcaac cgggctctgg ccgatttgca tctcctggtc
    11761 gacgagatcg tggccgaacg gagggcatct ggtcaaaagc cggacgattt gctgacggca
    11821 ttgctggagg cgaaggacga gaatggcgac cccatcgggg aacaggagat ccacgatcag
    11881 gtcgtcgcga tagtcacccc gggcagcgaa actgtggcct ccaccatcat gtggctgctg
    11941 catgtgctcg cggaacatcc ggaacacgcg gcgagggtgc gcgcggaggt cgaatccgtg
    12001 accggtggcc gacccgtcgc attcgaggac gtccgggcgc tcaggcacac caacaatgtc
    12061 gtcgtggagg cgatgcgttt gcgccccgcg gtctggattc tgacgcgacg agcggtgacc
    12121 gatacgtcac tcggcggcta tcgcattccg gccggggccg acatcatcta cagcccctac
    12181 gcgatacagc gcgacccgaa gtcgtacgcg cacaaccttg agttcgaccc cgaccgctgg
    12241 cttccggaac gcgtgaagga ggtgccgaag tacgccatga gcccgttcag cgtcggcaac
    12301 cgcaagtgcc cgagtgacca cttctccatg gcgcagctga cgctgatcac ggcggcgctg
    12361 tccagcaagt accgcttcga gcaggtgtcg ggctccaacg acgcgacccg ggtgggcatc
    12421 acgctccgcc cgcacgacct gctgctgaag ccggtgccct gggagtagtt caggctgcct
    12481 cggatccccg gaacgtcctg cggtaggcgt tcggggtcgt ccccagcgcg cgtacgaact
    12541 gatggcgcag cgcggccgcc gtgccgaacc ctgttcgacc ggcgatcgcg tccaccgtct
    12601 cgtccgtcgc ctccagcagc tcctgggcca gcaggacgcg ttggcgcagg atccagcggt
    12661 acggagtcgt gccggtctcc tgctggaagc ggcgggcgaa ggtgcgcggg gacatgtgcg
    12721 cgcgctcggc gagctgctcg acggtgacct cctcgtcgag gtggcgctcc atccaggcca
    12781 gcacctcgcc gaccgtgtcg cactgggagc gcggcagcgg acgctcgatg tactgggcct
    12841 gcccgccgtc ccggtgcggc ggtaccacca tccgccgggc gatcttgttg gcgacctcgg
    12901 gcccctgctc ctgccgcacg atgtgcagac aggcgtcgat cccggcggcg gtgccggcgc
    12961 tggtgatgac cgggccctcg tcgacgtaca gcacatcggg ctcgacgatc gcccgcggat
    13021 gccgtaggga cagttccgcg gcgtgccgcc agtgcacact gcaccgccgc ccgtcgagca
    13081 gtccggccgc gcccagcacg aacgcgccgg agcacacgct gagcacccgg gcaccccgct
    13141 cgacggcgct gaccaggcag tccagcagct cgggcggata gtcgcgggtg acgtagtcgt
    13201 tgccggccgg cacggtgatc aggtcggcct cggccagccg ctccaggccg tacggcgtgg
    13261 agagggtgag cccgccgacg tgtgtggcca gcgtcgggcc ctccgcggag acgacggcga
    13321 agtcataggt gggcagcccg tcgtcactgc ggtcgatgcc gaacacctcg cagacgacgc
    13381 ccagttcgaa ggggtgcaca ccgtcgagga ggacggcggc gacgttcttc agcatgctgc
    13441 cagtgtgccg tgtctctggc agtaaatcga gagtgtgcgg cagtcctgcc actgtcagga
    13501 gcatggggcc gcgacgatga ttaccgcatg aacgcattcc tcggatacgt caccgtcctg
    13561 gtcctcttcg tcctcctcgc gggcccggcg ctcgtggggc atctccacga gcgccggatc
    13621 gaccgccagt tgagggcggc ggagcactcc gccgcgactc ggaaggctca gcaggctcag
    13681 agggctgagc aggctcagaa gtcctcgtcc aggtcgacgg tgccctccac cgccacctgg
    13741 tacgccgacg gacgccgctc gaagaagttg gtgagctcct gaacgccctg cagctccatg
    13801 aaggagaagg ggttctcgga gccgtacacc ggagcgaagc cgagacgcgt cagacgctga
    13861 tcggcgacac actccaggta ctgccgcatc gagtcggtgt tcatgcccgg gaggccgtca
    13921 ccgcacaggt cgcgcgcgaa ctgcagctcg gcctcgacgg cctccctcag catgtcggtg
    13981 acctgctgct ggagctggtc gtcgaagagc tccggctcct ccttgcggac ggtgtcgacg
    14041 acgtcgaagg cgaaggacat gtgcatcgtc tcgtcgcgga acacccagtt ggtgccggtg
    14101 gccagaccgt gcagcaggcc gcggctgcgg aaccagtaga cgtaggcgaa ggcgccgtag
    14161 aagaacaggc cctcgatgca cgcggcgaag cagatcaggt tcagcaggaa gcggcgccgg
    14221 tcggccttgc tctccagccg gtcgagcttc tccaccgagt ccatccactt gaagcagaac
    14281 tcggccttct cgcggatgga ggggatgttc tccacggccg cgaaggcggc ggcgcggtcc
    14341 tccgggtcgg ggaggtaggt gtccagcagc gtcagataga actggacgtg gacggcctcc
    14401 tcgaagagct ggcgcgacag atacaggcgc gcctccgggg agttgatgtg cttgtagagg
    14461 gtcagcacca ggttgttcgc gacgatcgag tcacccgtcg cgaagaaggc caccagacgg
    14521 ccgatgaggt gctgctcggc gggcgtgagc ttggccaggt cggccacgtc cgagtggagg
    14581 tcgacctcct ccacggtcca ggtgttcttg atggcgtccc ggtagcgctc gtagaagtcg
    14641 gggtagcgca tggggcgcag ggtcagctcg aagcccgggt cgaggagatt ctgattacgg
    14701 gtggtcatta ctggcaggcc tcgcaggact cggggttttc cagggagcag gcgacggcgt
    14761 cttcgggcgc cggctgctga acggggatgg tggcttgggc ctgcgcctgg gcggcgcggg
    14821 cgatgcgggt cgccgggcgc gagcgcaggt agtacgtcgt cttcaggccc tgcttccagg
    14881 cgtacgcgta catcgaggag agcttgccga tggtcggcgt ctccatgaag aggttcaggg
    14941 actgggactg gtcgaggaag ggggtccgcg ccgccgccat gtcgatcagg ccgcgctgcg
    15001 ggatctccca ggccgtgcgg tacagggccc gtacgtccgc cgggatccag gcgaagtcct
    15061 gcaccgaccc gcccgagtcg cgcagggcct cccgggtgcg ggcgtcccag acgccgagct
    15121 ccttgaggtc gttgaccagg taggagttga cctggaggaa ctcgccggag agcgtctcgc
    15181 gcttgaacag gttggacacc tgcggctcga tgcactcgta gacgccggcg atggacgcga
    15241 tggtggcggt gggcgcgatg gcgagcagca gggagttgcg catgccggtc gtggcgatac
    15301 ggctgcgcag ggccgcccag cgttccggcc aggtcagctc gacgtcgtag tggtcggggt
    15361 ggaggacccc acgggccgta cgggtcttct cccaggccgg gagcgggccg ccccgctcgg
    15421 cgaggtcggc ggacgcctcg tacgcggcga gcatgatgcg ctcggcgatc cgggtggaga
    15481 gccgcttcgc ctcggccgag tcgaagggca gccgcagctt gaagaagacg tcctgcaggc
    15541 ccatcgcgcc caggcccacc gggcgccact tggcgttcga gcggcccgcc tgctcggtcg
    15601 ggtagaagtt gatgtcgacg acgcggtcga ggaaggtcac ggcggtgcgg acggtggcgt
    15661 ccagccgctc ccagtcgatg tcctgacgcg tcgggtccac gaaggcgccc aggttcaccg
    15721 accccaggtt gcagaccgcc gtctccccgt cgtccgtgac ctccaggatc tccgtgcaga
    15781 ggttcgagga gtggacgaca tggccgggca gggccgtctg gttggcggtg cggttggcgg
    15841 cgtccttgaa cgtcatccag ccgttgccgg tctgcgcgag ggtgcgcatc atacggccgt
    15901 acaggtcacg ggccgggatg gtcttcctgg ccaggcccgc ctcctcggcc ttgcggtagg
    15961 cggcgtcgaa ctcctcgccc cacaggtcga ccagctcggg cacgtcggcg ggggagaaga
    16021 ggctccactg tccgtcggcg ttgacccggc gcatgaactc gtccgggacc cagtgcgcga
    16081 ggttcaggtt gtgcgtacgg cgggcgtcct caccggtgtt gtcgcgcagc tccaggaact
    16141 cctcgatgtc ggagtgccag gtctccagat acaccgcggc ggcacccttg cgccggccgc
    16201 cctggttcac ggcggcgacc gaggcgtcca gcgtcgtcag gaacgggacg atgccgttgg
    16261 agtggccgtt ggtgccgcgg atcagcgaac cccgggagcg gatgcgggag tacgagaggc
    16321 cgatgccgcc ggcgtgcttc gacaggcggg cgacctggtg gtagcggtcg tagatggagt
    16381 ccagctcgtc cttgggggag tcgaggaggt agcaggacga catctggggg tgccgggtgc
    16441 cggagttgaa gagcgtgggg gaggagggca ggtagtcgag gcggctcatg agtccgtaga
    16501 gcgcggcgac ttcgtccacc gacccggcgg tgtcgtcctc ggctaggccg gcggcgacgc
    16561 gcagcatgaa gtgctggggc gtctcgatga ccttgcgggt gagggggtgc cgcaggaggt
    16621 accggctgtg cagggtgcgc aggccgaagt agccgaagcg gtcgtcggcg ccggtgtcga
    16681 tgagggcgtc gaggcgggcg gcgtggacgc gcacgaactc ggcggtgcgg tcggcgatga
    16741 gcccctcccg gtgcccgacc gcgaccgact cggtgaagga cgtgacgccc tgggaggcgg
    16801 cctcggcggc gatggagatg gtcagcagcc gggcggccag ccgggagtag gcggggtcct
    16861 cggagatcag gccggccgcc gcctcggtgg ccagctcgcg cagctccgca gtgatttcgg
    16921 aggcagcccg tgcggaccgg ccgcgcagcg cggcggcggc gacccggccg gggtcggcgt
    16981 cggggaggtc ggcggtcagc tcggtcaggg tccgcagcag cgcggcaccg ggaccgtcgg
    17041 tgtccaccag ggctgctgag gccggatctg ctggcgcgat ggtcacgtgg ggctctccct
    17101 cgctcggcac gggggcctcg ccgagggcag gggcagcaca cgagcgcacg gggcgtcgcg
    17161 tccaccggcc cattccacga ggcccggacg tcaggcacgc cgaccggatg gccgggtgcg
    17221 ctgtcggcag gtcctcggac tgactcctgt gcacggcggt tccgggaaca gacatgcaca
    17281 agtacaccgt tgcgggacag ttccggattc gcaccggatt cccctgcggc gacagcgagg
    17341 atgagcatac atcttgtgct cacctgccac gccaccccca gatgttgtgt cgcggtggtg
    17401 tcagagcgtc aactcatagg tgagaagagt gatgtcggac aggtgcggga tcggattcca
    17461 gtcccgctcg ggtgtgcgga cgaagcccag gcgttcgtag atgcggtggg cgctgtgcat
    17521 ggtgcgctgg ctcgacagga cgatgcgtac acagccgtcc gtggcccgtg cccgctcgac
    17581 gcaggcgcgt acgagggcct cgccggcgcc ccggccgcgt gcctcccgcg agaccgccag
    17641 catgcggatc tccgcctcgc cggggccggc tatgtcggcc atggggccgc cggacggtac
    17701 gaaggtgacg ccgccgacga cgcggccgct gtgcacggcg accagcacct cggcggcggc
    17761 cgcccgcttg gccacgtcct tcagctcgcc gaggtactcg tcgctctccc cgaagtcgag
    17821 cagaccgtcc tggagatagg cctgcgcggt gatctcaccg agggcctcgt actcgtcggg
    17881 ttccacctgc cggatcacga tgtccatgca ggtcagtgtg gcggacgggt acgacaacgg
    17941 gccgccggac ttctccggcg gcccgtcgat gacaggtgct cagtgggacg agcccgcagt
    18001 cgccggcggc agctccacct ggacacccgg gtcgcccgcg tccgccgtgt agtcctccgg
    18061 cctcgtctcg tcgacgccct ccggagcctt cgccgccttc aggacgaagg tcagcaccac
    18121 ggtcaccacc acgttcagca cgaacgcggt cagaccgatg tagccgatct ccccgatgcc
    18181 cgggatctcc ttcgcggagc cgccgaagtg cttctgcgtc ggcgacgcca cgccgtacgc
    18241 ggccaccgtg ccgtagacca tgcccaccgc ccagccggcc agcagcgccc agcggtggaa
    18301 ccagcgcgtg aacagaccgc cgaccagcgc cgggaaggtc tgcaggatcc agatgccgcc
    18361 cagcagctgg aagttgatcg cgaccgtctt gtccatggtg aggacgaaga ccagggcgcc
    18421 caccttcacc agcagggaca ccagcttcga caccttggtc tcctgcgcgg gagtggcgtc
    18481 cggcttgatg aagtccttgt agatgttgcg ggtgaagagg ttcgcggccg cgatggacat
    18541 gatcgcggcc ggcaccagcg cgccgatgcc gatcgccgcg aaggccacgc ccgcgaacca
    18601 ggacgggaac atgtcctcga agagctgcgg gatcgccaac tgggggttgg tgaccgagac
    18661 tccggccgcg atcgccatga agcccagcag ggccagcagg ccgagcatga gggagtacag
    18721 cggcaggatc gtggtgttgc ggcggatcac ctcacggctc ctggaggaga gcgtcgcggt
    18781 gatcgagtgc gggtacatga acagcgcgag cgcggagccc aacgccagcg tggcgtacgt
    18841 ccactggccc gcctccggcg ggatcaggcc gcccgcaccg gccttcgtgt acttctcgct
    18901 ggccgcggtg aagatctcgt cgaacccgcc cagcttgatc gggatgtaga tgatcgccac
    18961 cgcgatcacg atgtagatca gcgtgtcctt gacgaacgcg atcagcgcgg gggcgcgcag
    19021 tcccgaggag taggtgtacg ccgccagcac accgaaggcg atgaggaggg ggaggtcctt
    19081 gatgaaccag ttggtgttct cgccgccgcc cacgcccatc acgtccagca ccgcctggat
    19141 gccgaccagc tggagcgcga tgtacggcat ggtggccagg aggcccgtga cggccacggc
    19201 cagcgacagg cccttggagc cgaagcggcc gcgcacgaag tccgaggtcg tcacatagcc
    19261 gtgcttgtgg gagaccgacc acaggcgggg caggaaggtg aagatcagcg ggtagacgag
    19321 gatcgtgtac ggcaccgcga agaagccggc cgcgcccgcc gcgtagatcg ccgccgggac
    19381 cgccacgaag gtgtacgccg tgtacaggtc gccgccgagc aggaaccagg tgatccaggt
    19441 gccgaacgac cggccgccca ggccccattc gtcgaggctg tgctcgttct cggccttgcg
    19501 ccagcgcgcc gccaggaagc ccatgaccgt gacggccagg aagaagaaga tgaagacgcc
    19561 gagcgcgacg ccgttcacac cgccgttcat tccgccgcac cgcccttctg ggaggcgcgg
    19621 gcgcgctggt cacgctgcca cagcttgtac gcgaccatcg tcagcagcgt ggagagcagg
    19681 acccacagca tctggtacca gtagaagaac gggatgccgg cgaactccgg atcggtcttg
    19741 gcgtacgaac cgacccacag catcgccacg aagggcgcgc cgaggcagag cgcgatgacg
    19801 acccgtatgg gtgtcaccac cgctctgttc acttctgggg catctgacat ctgacggctc
    19861 cgtcccctca ctgatcacct atgaaacgcg caggcaatgt aggtgacggt gcaacgacag
    19921 cggaagaccc cgtccgcata tcggatgtgg agggttggtg tgcggagcgg cggggcgctc
    19981 agcagcagcg gaacccctgc cgcgggtcct gctcctggcg gtcggtccgc atccgttcga
    20041 aatcgcgtcg ggagggcacc cgcgcgtcgg ggtgctcgcg ccgcaggtgc gcgacatagc
    20101 ggtcgtacgc cgattcgtcg gtcagctcgc gcacgtacca gcgcacacct ctaagaaccc
    20161 gccgaagcga ccgcacgacg ctcctcctcc ttctcctcct tcgtcgggaa cagcccggcc
    20221 ggagcggtga tcttcgactc gacgtacggc gcctcgctca gcgtcgacag ggccgggcgg
    20281 cggacatgcc ggacgcagac ccgcaacgcg tcggcgatca cgacgacgat caggagcgcg
    20341 aggaccgccg agaggacgcc gtcgaccgtg gagttggtga ccacggtgtg catgtcgtcc
    20401 atgctcttgg cgggcggcag gacctcgccg cggtcgatgg cgtcctggaa cacctggcgc
    20461 tgcttgaaga agccgacctt cggatcgctg gagaagacct tctgccagct ggcggtgagc
    20521 gtcaccgtgg cgtcccaggc gagcgggacc ccggtgatcc aggcccactt gaggcggccg
    20581 gacttcacca gcagggtcgt acagacggcg agggcgaccg cggcgagcag ctggttcgcg
    20641 atgccgaaga tcgggaacag ctggttgatg ccgccgaggg gctcgtggac gcccacccac
    20701 aggaagtatc cccacaggcc gcacaccacc gcgctggtga cgaccaggcc gggcttccag
    20761 ctgacgttcc tgaagggccg gtggacgttg cccagcatgt cctggagcat gaaccggccc
    20821 acccgggtgc cggcgtccag cgcggtcagg atgaacagcg cctcgaacat gatcgcgaag
    20881 tggtaccaga aggcccgcaa gccgccgccc gtgacctggg agaagatctc cgagacaccg
    20941 atggcgaggg tgggcgcgcc gccggtccgg gagagcaggg acgcctcctc gacgttctcc
    21001 gccgcccggg cgagcgcctc gggtgagatc tggtagcccc aactgcccac gacctgcgag
    21061 gcgttctgga cggtgtcccc gatgac
//
