LOCUS       NZ_KQ947989            22010 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s006, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ947989
VERSION     NZ_KQ947989.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 676431)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 676431)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 383161
            Orig. end                         :: 405171
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ947989.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22010
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22010
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22010
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12010](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12010)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(918..3134)
                     /locus_tag="AQI70_RS21900"
                     /old_locus_tag="AQI70_21895"
     CDS             complement(918..3134)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014896.4"
                     /locus_tag="AQI70_RS21900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21895"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_062152671.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.9e-46, bitscore:
                     152.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTQQAVGSAVPGNPPLPFAPLAYPAASRLPVADELHGERVPDP
                     YRWLEEDEGAACERWLTEQDQLFAAHASSWPSGRYFRALLGELQELGGALAPVVSPPVW
                     RGARRFFLRRDQGAQLPVLVAADGIEGHRESERVLVDPMALDSAGLTLLTSWRPSWTGR
                     LLACQFTHRGSESPELRVLDVAGGQVMDGPLRPGRPSPVAWLPDDSGFFYVTHGNASGS
                     RGVRLHRLGSDPGADPLVFDTTHAHLSVAISPDGRWLTVSSSPGAQSGNDLRLADLSHT
                     GPESPELQLIHQGSADCTSALLRFGPDGLLYAVTDADAPYGRVCLVDPADPRRQAWSTL
                     ITPEPDALLTACTALTDPGSGQLRLLVGTTRGGTVRLAVHDGAGRKLADVPTPGTGPGT
                     ISNLSTPPGDTGQVWFTYTDFVTPPAVYRFCARQGRCFPEQPADATAPTPVVPVVRQLT
                     YHSEDGTSVGLYLIEPPEPATGPRPTILTAYGGFGALAAPAYSPTIMAWVRAGGVYAIA
                     GIRGGGEHGTAWHAAGSGVNKPACFADFAAAARHLIDEGVTSPDRLAIKGASHSGLVVA
                     VALTRDPRLYAAAVCSDAPTDMVRYPRFGLGPLWAPEFGTPDDPDQLAVLLSYSPYHQV
                     RPDTHYPAVLLTSARIDPRVGAAHMRKFTAALQHATASNRPVLLRTEADVGHGYRTASR
                     WADLAADTLAFCATHTGLTPAADEPWATAPPANPVVDAPGIRCA"
     gene            complement(3373..4482)
                     /locus_tag="AQI70_RS21905"
                     /old_locus_tag="AQI70_21900"
     CDS             complement(3373..4482)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567296.1"
                     /locus_tag="AQI70_RS21905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21900"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_062152672.1"
                     /transl_table=11
                     /translation="MTIAIVGAGLGGLALARVLHVNGIDAVVYERESSRRARGQGGMLD
                     IHSGQRALREAGLIDEFYAIARGEGQDMRLLEPDGTLLLQEDTPDDAPLDRPEVDRADL
                     RDLLLDSLPEGVVRWGHAYKSADNGLLHFVDGSSATYDLLVGADGAHSRVRALLTDARP
                     AHIGQNVVEVGIPDIDRTHPDLAAMVGRGNYWVLGNGLSLAAQRNGDGRVRIGLSFYNT
                     PEDWFATSGIPFDDPSAARARLIDLLHGWDSRFTALIAACDDTIVPRPITTLPVGLTWP
                     SKPDVTLLGDAAHLMPPVGEGANMALLDGALLGLALAAHPDDFPAAVKEYEREMFERTS
                     AAARMSADIQELLMSPDAAQKMLAFFQPG"
     misc_feature    4513..4529
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.42"
                     /tool="antismash"
     gene            4554..5234
                     /locus_tag="AQI70_RS21910"
                     /old_locus_tag="AQI70_21905"
     CDS             4554..5234
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329288.1"
                     /locus_tag="AQI70_RS21910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21905"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_062152673.1"
                     /transl_table=11
                     /translation="MLVWERPEPPNRPVPAPLNRERIVRAAIRLADADGLEAVSLRKVA
                     TALGVGPMRLYSYIAGKEELLDLMVDAVHAEIRPVGDDWREVLRSLAETTRQAAHEHEW
                     LADLLGGRPQLGPHALARGEAVVAALDGVDVDDIMPVVTAVEAYVIGAVRREIAERRAE
                     RATGMDEKRWQASLGPYLERTFATGRFPALATVVRDAAHLDADHTFRIGLDFLLDGIEA
                     RISR"
     gene            complement(5399..6469)
                     /locus_tag="AQI70_RS21915"
                     /old_locus_tag="AQI70_21910"
     CDS             complement(5399..6469)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012575.4"
                     /locus_tag="AQI70_RS21915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21910"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_079051439.1"
                     /transl_table=11
                     /translation="MARWHRHSRSQNPKRPYGDGNAPLPYPTGWFMLAPSRDVRPGAVL
                     TLRLMGEDVVVYRTQSGRLNVVRPYCPHLGTHLGCGGWVDGENIVCPFHRFAFDLDGAV
                     ARVGPGYTGQPVRDKLLLLPSEEVNGGIYVWVGADAGEAPHWRIPPVLEATGMKFARIQ
                     VGTHPQEISENGVDLRHQQALHAFAEAECVGEPVLDRHRYSYTMHLTQATPFGRVLAEG
                     AISFYGLGFYHLVFRVPQYRLQHDIAVGIRALAPWQSEMLVGTRVTVDAARPPLSRLPR
                     TVTDALSEAASGLGLASAKRLLTQDVPIWHGKRYINPPRIARGDGPIGGFRKWAEQFYP
                     AQGSPGPEAMETGCRD"
     gene            6749..8338
                     /locus_tag="AQI70_RS21920"
                     /old_locus_tag="AQI70_21915"
     CDS             6749..8338
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013714.4"
                     /locus_tag="AQI70_RS21920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21915"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_062152676.1"
                     /transl_table=11
                     /translation="MTGTPEPSVRDTPTPPVPPDTSTGTRLPSTLVRHGFSVLVPLLLP
                     VGKAFSLARSTYAACRRVLRRRTPHEERIARLQTTVRRLAGERAGPLCTGTKEWQSVSV
                     PREHSYKRRARPVGLGLDAILELDTERRVIRVEPGVTMGRLVRHLVRRGWTLPVVPELE
                     ALTVGGLTMGFGIETSSHRHGLFADTVESYEVLLGTGEVVRASATEHTDLFHALPWSMG
                     SLGFVLAVELRIVPAAAWVEVRYHPVADLSDMCRDITRLADRADGPAFVEGFVYGPDEG
                     VVVTGEFTDRPTGRQNRVCRWNKPWFHAYARDCARAGGRVEYVPLRQYYHRHSRSLFWA
                     GELLVPFGNHPLFRLPFGWLMCPSIEFLKLIDTDRRRRHTVAQEALVPARHLEGLVRHC
                     HEVFEVDKLWICPARLTRREPPGLVGPGPDVAPGQGMLFMDVAVIHDVPGPVRRGEPWD
                     QREATRRFEAWVGGHDGFQAPYVLSELTREEYRAMFDCRLYDRVRHAYGGEGVFVDAYE
                     KITSGWAMAPGK"
     gene            complement(8394..9764)
                     /locus_tag="AQI70_RS21925"
                     /old_locus_tag="AQI70_21920"
     CDS             complement(8394..9764)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013739.4"
                     /locus_tag="AQI70_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21920"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_062152678.1"
                     /transl_table=11
                     /translation="MTKPLRVCVVGAGMAGLGAAWALDRHPEKFTVHVFEAKGRLGGNG
                     CTVDLPMEDGSHLPVDMAVTSFIPAVYHNFAALLRWCGIEAVPTRFSYAVEYQGSEYAH
                     DTDSTLKRRYRRDLDAFLRMLRVLRAWNTLSKRPSRAATAANPFQYVSVRRVLDWWGIS
                     TGFRYAILKPISVNFVLATDIFEMPAALFCRYFDFFDIEASTPMMTWQGGTREIYRKMT
                     AGFQDRVHLDRPVTAVLRDEHGVTIRDAAGCEERFDTVVMACNANQSLLALDRPSAWER
                     ALLGRVRYNSELHNHAVVHGDTSVLPADAADEMLATRSNFIRQYGTRPDNYEITYLMHN
                     QQPWIREAGRHCLVTYNPERPVDPDTVVAREWFQHVAYDVRHMNALMPLFPRLQGRRRT
                     WYCGAHTLVNSQELALVSGLSVARQLGAEFPFPDDQEARTWFNFYGRVVQGRAFRRV"
     gene            complement(10001..12010)
                     /locus_tag="AQI70_RS21930"
                     /old_locus_tag="AQI70_21925"
     CDS             complement(10001..12010)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01787.1"
                     /locus_tag="AQI70_RS21930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21925"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_341845961.1"
                     /sec_met_domain="T2TS (E-value: 6.3e-105, bitscore: 346.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVGDPVAPEDLPHPPRPPALSPRTAYRRAADRLVSEQRPDGCWE
                     GEMVWNTMILSQYVIVCAVTGNPPRQHEREAMIRHYRATVTGKGGWGPHSESSHPSLYC
                     TVLASVALRLLGVPADDPLCRGAAEWMRTLPGGPRAVPTWGKFWLALAGLYDYRGVNPV
                     PPEMFLLPRWVPVHPNRFYCHTRSVYQAMAYLYGARFQADLGPLGAQLRHELFGSDTLP
                     RERRCAGTDIHRPAGPLLHAVNAMLSGYELRPAPLLRRRALNRCLRRVEHEQLVTGELG
                     LSPVNALLNVLVLHAARPGSAAVARALAAQAYWRWTDEAEGTRYAGARSQTWDTGFAVE
                     ALLAGQAGHEPEPAVADAVRRAAAFLRGAQVTEEIPQPTVTARSPALGGWCFSEGGHRW
                     PVSDCTAEALAALAHAARAVPGAGGLPDENLRHAVRFLLERQNRDGGFGTYERRRGGRW
                     LEALNPSEMFSDCMVEGSYVECTASALTAFAALPAHALGPLSSAVDRSCRRAVAFLLRR
                     QEADGSWPAAWGVNRIYGTWFAVRGLRAAGLPADHPRLRRAAGWLRAVQRADGGWGEHH
                     RGCTENRYAEHVRSQPVSTAWSLLALLDTGGPKDPVVVRGVDWLCRAQRPDGTWEQTSV
                     NGVFFGTGLLDYRLYARYFPLWALGRWLDAREAS"
     gene            complement(11916..13118)
                     /locus_tag="AQI70_RS21935"
                     /old_locus_tag="AQI70_21930"
     CDS             complement(11916..13118)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039236.3"
                     /locus_tag="AQI70_RS21935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21930"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_063801609.1"
                     /transl_table=11
                     /translation="MSSDRPTTPAGRPAAGPPDFADARNKRQKARAAGLDPDYWYAVEY
                     EHAVTPGQVVGTRFWGRDIALYRGEDGTLRALEDRCAHRQLALSRGQVEGCHLTCMYHG
                     WSYDGTGRVVHYAHDLFGRAQPEVKVRSYPVTARHGLIWLFPGDPTLAQGRRIPDIPEL
                     DGPRPWARIDADYTWRAHHSMIIDNVSDFTHAYLHRKYRPFWDARLTHCETVGDTVRLS
                     YDTVIGGGRLTGRFVDRRRVDTTSIDLAYEYPYQRSDTGGAIKHWCFVLPMDRTTTRVF
                     FLFYFDALKIPGTRARVPRPLMGPLMKAAAVLAVRPLLRQDGTAVEAEQEGYERNFASP
                     LVELNPAVHLFQDLTIRKWEQYLEREKATSVRRRSSGAGGSSAPPAPAGPLAPDGVPPR
                     G"
     gene            complement(13115..14545)
                     /locus_tag="AQI70_RS21940"
                     /old_locus_tag="AQI70_21935"
     CDS             complement(13115..14545)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="AQI70_RS21940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21935"
                     /product="cytochrome P450"
                     /protein_id="WP_062152682.1"
                     /sec_met_domain="p450 (E-value: 9.7e-57, bitscore: 187.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLVRGPSVDRPEAPPRLGGFRLPWVGHALPFGHNPVDFLRRAR
                     RRAGDVFAFTLLGQPVVFLCGPAAQEAVFRADEAVLSPREAYRFMTPVFGRGVAYDAEP
                     EEMDRQIGHLLPALTSRRLAAHAQVMEDETEAYFGSWGESGTADLVATMNELTVRIATR
                     CLLGPEVSRRLGPDLPGLYRDLESGIRLAGLLNPGLPLPAFRRRDRARAAIGRALAEVI
                     AERRAAGRLSGATRGEEPEDMLATLLSARTPDGDPLPDETITGLLIGMIFAGQHTSAVL
                     AAWTGVLLLSHPGHLPPLLAEQRETVGAGGPLTVPLLRRMERLEWCVREAERLHPPLVV
                     LIRKALRDFRYGRHVVPAGTLVMISPAVSHRLPEVFRDPDLYDPGRYAPGREEHTVPYA
                     LIGFGGGKHRCVGMAFAYQQVKAIWSVLLRRYELGLGAGPHPPDYSTFVPAPRSPCLIR
                     YRRCPALDRPGRTAEAFS"
     gene            complement(14542..15615)
                     /locus_tag="AQI70_RS21945"
                     /old_locus_tag="AQI70_21940"
     CDS             complement(14542..15615)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (3-173). E-value: 3e-17.
                     Score: 54.5. Matches aSDomain:
                     nrpspksdomains_AQI70_RS21945_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF027681.4"
                     /locus_tag="AQI70_RS21945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21940"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_159042695.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5e-12, bitscore:
                     40.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.6e-06, bitscore:
                     22.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.9e-16, bitscore:
                     54.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLVTGGSGHLGANLVRRLLDDGEEVRVLISGERSTQPEALEGLA
                     VQRVFGDLRDPAATDRAVAGCDRVYHCAAQVSTTSGGKRDIYRTNVLGTRHVLDAARRH
                     EVARVVVTGSFSATGETAFGRPSTEDMPFYPFARHTPYTVSKVLVEHECLRAAASGLDV
                     VIAASTAIIGPHDYRPSRMGRVLLDFAEGRLRAYVPGGFEFVSAQDVVEGHVLAMRHGR
                     AGRKYLLSTEFRTVDEMMDLYSAVCGRPRPSLRVPGAVMAGVAELVQPLRAVLTPHRPG
                     RFTPAAVRFLRSQRRADCSRAADELGYRPTSIATAVEQAYDCFVRRRLISGGRRIAVTS
                     RSGRQAAAAQSVAASAR"
     aSDomain        complement(15097..15606)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS21945_NAD_binding_4.1"
                     /evalue="3.00E-17"
                     /label="AQI70_RS21945_NAD_binding_4.1"
                     /locus_tag="AQI70_RS21945"
                     /protein_end="173"
                     /protein_start="3"
                     /score="54.5"
                     /tool="antismash"
                     /translation="VTGGSGHLGANLVRRLLDDGEEVRVLISGERSTQPEALEGLAVQR
                     VFGDLRDPAATDRAVAGCDRVYHCAAQVSTTSGGKRDIYRTNVLGTRHVLDAARRHEVA
                     RVVVTGSFSATGETAFGRPSTEDMPFYPFARHTPYTVSKVLVEHECLRAAASGLDVVIA
                     ASTAIIG"
     CDS_motif       complement(15553..15609)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS21945_0001"
                     /evalue="1.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="AQI70_RS21945"
                     /protein_end="21"
                     /protein_start="2"
                     /score="11.3"
                     /tool="antismash"
                     /translation="LVTGGSGHLGANLVRRLLD"
     misc_feature    complement(15653..15667)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.94"
                     /tool="antismash"
     gene            15780..17093
                     /locus_tag="AQI70_RS21950"
                     /old_locus_tag="AQI70_21945"
     CDS             15780..17093
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1161: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="AQI70_RS21950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21945"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_062152686.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.7e-08, bitscore:
                     27.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.4e-08, bitscore: 29.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSADVVVVGAGPAGCACALSFARRGVRVLLLEARRAPVHRLAGE
                     WIQPAGVAALRLLGVDVHRDGPGTAKRGFVMHPGDGSAPIALPFSAGEAVSLPHAELTA
                     LLRRAVADHPAVELRTDVRVLTAEASGLVRTSRGSVHGELVVGADGRASVIRAALRAER
                     ADRTPFSYTAGLLLPDAALPRERYGHVMLGGPGPALAYRLNTGTVRLCLDVPPGRPSAP
                     ALRSYLWHGYAEALPACLRTAVAEQLRAGRVQWAANLFQPHAFYGSGRRALVGDAAGCV
                     HPLSASGLTSAFLDGECLARSADVAAYARERSAACRVSDRLAACLHRILTDRSPATRAL
                     REAMFTVWREDERRRDRMLRLLAMTELRRHTFGTAFLHVLARALSSSARKAVIDGQWTE
                     VARELTGFAGWLQWIAQLRAGAPASPAGVHRALALLGP"
     gene            complement(16990..17604)
                     /locus_tag="AQI70_RS21955"
                     /old_locus_tag="AQI70_21950"
     CDS             complement(16990..17604)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017090.4"
                     /locus_tag="AQI70_RS21955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21950"
                     /product="emopamil-binding family protein"
                     /protein_id="WP_062152688.1"
                     /transl_table=11
                     /translation="MGRRSPEDRITLGFLAFSFLLAFTLELYFVLHFQDIGGRRDVFAR
                     LFQVYGAGDSAYAGEGDVYFPFALETIHLTVTQVLSVGITVGVLRNRPYRYPLQLAVSS
                     YVAYSVVLYFWRAVVGGYENMPERGAWNYFIFYVPNLPWLLGNLLLAWYAYRAILRRFR
                     GEAQDDGVTAREGPGRGAHRPGTPGPPPATGRSIAASRRIR"
     gene            complement(17665..18741)
                     /locus_tag="AQI70_RS21960"
                     /old_locus_tag="AQI70_21955"
     CDS             complement(17665..18741)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013394.4"
                     /locus_tag="AQI70_RS21960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21955"
                     /product="hypothetical protein"
                     /protein_id="WP_062152689.1"
                     /transl_table=11
                     /translation="MVAVLGEGLTAAVFFTAFMVVLFLGTRCLPGRWAEGAPLADGSRE
                     RYRLNGMLLFSLCVLAVLVTALVRPTALAYPVRHWQALFVAANVFSLIAAVWLWADGRQ
                     RRGPGARSAAVDCFLGVRLNPKLAGVDLKMFAYRPSLIGLFLFNVSCAAAQGLEQGSLS
                     QRMILYQVMFFVYIANFFQFEEGMLFTWDVMSERFGWMLVWGDLVLVPFFYSLPGHVLI
                     DVSAPLGAGQALLSTSAFLLGFWVFRGANAQKHRFRRSGATHIWGRPAQTLEGRLLVSG
                     FWGIGRKLNYTGEFLVYAAWTSLCGASSMLPYLVLLWLSALFVHRARRDDRRCRAKYGE
                     LWDRYCRKVRYRLVPFVY"
     gene            complement(18853..19737)
                     /locus_tag="AQI70_RS21965"
                     /old_locus_tag="AQI70_21960"
     CDS             complement(18853..19737)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (57-236). E-value: 1.7e-31. Score:
                     100.8. Matches aSDomain:
                     nrpspksdomains_AQI70_RS21965_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="AQI70_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21960"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_159042696.1"
                     /transl_table=11
                     /translation="MSSEATRLARIQEVVSERESRERNYVEMVTSYFELVNDVYRSGWG
                     ESHHFPPFSDGQSLAEAQRTAQCRLADRAGLRPGTRALDIGSGVGGPALTIAAHSGAHV
                     TGLDLTPVRSECARTRAAEQGLTAQTDFVEGDALDMPFPDGSFDAVYSFDSIVHMPEKE
                     RVHREAARVLKPGGVYLGYDWLAADGLGDEETSRFIEPICRHHCLTHLSTPQTLAGHLR
                     DAGLDPVRVADASEQGSLEPVWLMLDEAADLLDDSDDVTPLLRFMQRGIRVLSAAAREG
                     AFLVGYWEARKPA"
     aSDomain        complement(19030..19566)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS21965_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.70E-31"
                     /label="AQI70_RS21965_oMT.1"
                     /locus_tag="AQI70_RS21965"
                     /protein_end="236"
                     /protein_start="57"
                     /score="100.8"
                     /tool="antismash"
                     /translation="SLAEAQRTAQCRLADRAGLRPGTRALDIGSGVGGPALTIAAHSGA
                     HVTGLDLTPVRSECARTRAAEQGLTAQTDFVEGDALDMPFPDGSFDAVYSFDSIVHMPE
                     KERVHREAARVLKPGGVYLGYDWLAADGLGDEETSRFIEPICRHHCLTHLSTPQTLAGH
                     LRDAGLDPVRVADASE"
     gene            complement(19727..20749)
                     /locus_tag="AQI70_RS21970"
                     /old_locus_tag="AQI70_21965"
     CDS             complement(19727..20749)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039286.3"
                     /locus_tag="AQI70_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_21965"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_062152694.1"
                     /transl_table=11
                     /translation="MSKELPLPYPDGWAAVAFGSELGTGKVIRTRFMDEDVVLFRTRDG
                     VAQAVTPYCPHLGAHLGYGGRVVGDRVVCPFHGFAFDRTGACVATGYGTRPPRVRLGTW
                     ETTEANGLVFVWYSARGVPPQWEVPSALMESFPSVMQCSRLLATHPQDTVENGIDLGHF
                     RYIHGLTDVQEGESFSSDGHQARYALAGVKSFPPGLLLRMEITTRLWGLGLNVVDTYFP
                     QLGVTLRSLVTRTATGPHQVRLRARVSARPDAGGKPFPPTSRRFRSLAALLTAAARPAF
                     TSQLALDVPVWAHKSYIPHPPLVQGDGPINLYRRWARQFYSAAQPVDGVTVERNISLEQ
                     "
ORIGIN
        1 gatctcgtaa aggaaggtgg cgccttccgc ttcggctccg gcgtggatgg cgatccgtac
       61 ggcgccgggg gccggcagga ctccgcgcag gcggcagcca tcggcgacgg gcgcgttcag
      121 gtgatacagc agcaggcggc tgacggcggc ctgctgctct cggtcttcgg ggtccgtcac
      181 ttgttcatcc atgggacgtg gtggcctggc gcgaccggtt ggggatcatc cctaccaaga
      241 aagtcatgac gcacagcttc gcagtgtgcc tgctctccga cctgcaccac acaggccagg
      301 tcctccccgc gcgacggcgg ccggttggca ggtgattatg cgccagggtt cgccagggtg
      361 cgccggatgg tgggccagtg ggagacaacc ctaggttgag gctgttcacc tccgcgccgg
      421 acacgtctgt cccagcggga cgctgggctc gcccaggacc tgggccgatc ccggaaggag
      481 gtggatatgc ggaagcggga acggagttca ggccgccgta agcgactgaa cccgacgacc
      541 cgggcgcagg tgatcatcgc tgcgctcgga gcggtcaccg cgatcgcagg atgtgcggca
      601 gagttcatgc gctagtgaag gtatgaacac ggtggtgtcc ggacggctgg tccatggctc
      661 gcgcgaagcg ggcccgaccg gcacatgatc ggccggaccc gcctcgacgc ttcgcacgtc
      721 cgcgtccggg ctctggaggc gaccagagcc cggaccctgc gaacctgcgg cctctgcacg
      781 agcagaggag ttcctcggac ggactccagt atcgttccga tctctgagaa atcggcaccc
      841 tggcgaccac aggttatggc tggcgaacgg gtggcgcgca gccactcccc cgacgccctg
      901 cctgcgattc ttctcgctca tgcacagcgg atcccgggcg cgtcgacgac cgggttcgcc
      961 ggcggtgccg ttgcccaggg ctcgtccgct gccggtgtca ggccggtgtg ggtggcgcag
     1021 aaggcgaggg tgtcggctgc gaggtcggcc catcgggagg ccgtgcggta gccgtgaccg
     1081 acgtcggctt cggtgcgcag gaggacgggc cggttggatg cggttgcgtg ctggagggcg
     1141 gcggtgaact tgcgcatgtg ggcagcgccc acgcgggggt cgatgcgcgc gctggtgagc
     1201 aggacggccg ggtagtgggt gtcgggccgc acctggtggt agggggagta actcagcagc
     1261 accgccagct ggtcggggtc atcgggggtg ccgaactcgg gtgcccacag cgggccgagg
     1321 ccgaagcgcg ggtagcggac catgtcggtg ggggcgtcgg agcagacggc cgccgcgtag
     1381 agccgcgggt cgcgggtgag ggcgacggcg acgaccaggc cgctgtgcga ggcgcccttg
     1441 atggccaggc gatcggggct ggtgacgccc tcatcgatga gatggcgggc tgcggcggcg
     1501 aagtcggcga agcaggccgg cttgttgacg ccgctgcccg ccgcgtgcca ggccgtgccg
     1561 tgctcgccgc cgccgcggat cccggcgatg gcgtagacgc cccctgccct gacccaggcc
     1621 atgatggtcg gcgagtaggc gggcgccgcc agggcgccga agccgccgta ggcggtcagg
     1681 atggtgggcc gcggaccggt ggctggttcg ggcggctcga tcaggtacag ccctaccgag
     1741 gtgccgtcct cggagtggta ggtgagctgc cggaccaccg gcaccacggg cgtcggtgcg
     1801 gtggcgtcgg ccggttgctc cgggaagcag cggccctgcc gggcgcagaa gcggtagacg
     1861 gccggcggag tgacgaagtc ggtgtaggtg aaccacacct ggccggtgtc gccggggggc
     1921 gtgctgaggt tgctgatcgt ccccggcccg gtgccgggcg tgggtacgtc ggccagcttg
     1981 cggccggccc cgtcgtgcac cgcaaggcgg accgtgccgc cgcgcgtggt gcccaccagc
     2041 agccgcaact gcccgctgcc cggatcggtc aacgcggtgc acgccgtcag cagcgcgtcc
     2101 ggttccgggg tgatcaaggt ggaccacgcc tgacggcggg ggtcggccgg atcgaccagg
     2161 cagacccggc cgtacggcgc gtcggcgtcg gtgacggcgt agagcagccc gtccgggccg
     2221 aacctcagca gcgcgctggt gcagtctgcg ctgccctggt ggatgagctg gagctcgggg
     2281 gactccgggc ccgtatggga gaggtcggcc aggcgcaggt cgttgccgct ctgggcgcct
     2341 ggcgaagaac tgacggtcag ccatcggccg tccggactga tggccaccga caggtgcgcg
     2401 tgggtggtgt cgaagacgag agggtcggcg cccgggtcgc tgcccaggcg gtgcagccgc
     2461 acgccgcgcg agccggacgc attgccatgg gtgacgtaga agaagccgct gtcgtcgggc
     2521 agccacgcca ccgggctcgg gcgacccggc cgcaacgggc cgtccatcac ctggccgccg
     2581 gccacgtcca ggacccgcag ttccgggctt tcgctgcccc ggtgcgtgaa ctggcaggcc
     2641 agcagccgac cggtccagga aggccgccaa gaggtcagga gagtcagacc tgccgagtcg
     2701 agggccatgg gatcgaccag tacgcgttcg gactcccggt gtccctcgat gccgtcggcc
     2761 gcgacgagca ccggcagctg agcgccctgg tcccggcgca ggaagaaacg ccgcgccccc
     2821 cgccataccg gcggcgacac gaccggcgcc agcgccccgc ccagctcctg caactcaccc
     2881 agcagcgcac ggaagtaccg gccgctgggc caggacgatg cgtgcgcggc gaacaactga
     2941 tcctgctcgg tcagccaccg ctcgcacgcc gcgccctcat cctcctccag ccaccggtag
     3001 gggtcgggaa cgcgctcacc gtgcagttcg tcggcgacgg gcaggcggga agcagcgggg
     3061 taggccaggg gtgcgaaggg cagcggtggg ttccccggca cggcggaacc caccgcctgt
     3121 tgtgtggagg tcaacgccgt cagtcgttgt cgccctccgt cagctcctgc cgccactcag
     3181 gcaggctgag gatctcgtcc gcgagaagga aaggactgcc gagcagtccg ggcagttcgt
     3241 ccattgcacg ctccttacag gatcgggttc attcagaccg tatttccgct gctcgacaaa
     3301 cacatcctgg gctgacccat ccaggtgagc ccggcgagga cgtaccgggg tcctggtcgt
     3361 atttcgttgc cttcagccag gttggaagaa tgcgagcatt ttctgggcgg cgtccggcga
     3421 catcagcaac tcctgtatgt ccgcggacat ccgggcggca gcgctggtgc gttcgaacat
     3481 ctcgcgttcg tattctttga cggcggcggg aaagtcgtcc gggtgcgcgg ccagcgcgag
     3541 accgagcagg gcgccgtcga gcagcgccat gttggcgccc tcccccaccg gcggcatgag
     3601 gtgcgcggca tcgccgagca gcgtgacgtc tggcttcgac ggccaggtca ggccgaccgg
     3661 gagagtggtg atcggccgcg gcacgatcgt gtcgtcgcag gccgcgatca gcgcggtgaa
     3721 ccgtgagtcc cagccgtgga gcaggtcgat cagccgcgcc cgggcggcgg acgggtcatc
     3781 gaacgggatc ccgctggtag cgaaccagtc ctcgggggtg ttgtagaagc tgaggccgat
     3841 gcgcacgcgg ccgtcgccgt tgcgctgcgc cgccagggat agtccgttgc cgagcaccca
     3901 gtagttgccg cgcccgacca tcgccgcgag gtcggggtgc gtgcggtcga tgtcgggaat
     3961 gccgacctcg acgacgttct ggccgatatg cgccgggcgg gcgtcggtga gcagtgcgcg
     4021 gacccgggag tgcgccccgt ccgcgccgac cagcaggtca tacgtcgcac tgctgccgtc
     4081 gacgaagtgc agcaggccgt tgtcggcgga tttgtacgcg tgcccccagc gcaccacgcc
     4141 ttcggggagg gagtccagca ggaggtcgcg cagatcggcg cggtcgacct cggggcgatc
     4201 gagcggggcg tcgtcggggg tgtcctcctg gagcagcagg gtgccatccg gctccagaag
     4261 acgcatgtcc tggccttcac cacgggcgat cgcgtagaac tcgtcgatca gaccggcctc
     4321 gcgcagcgcc cgctggccgg agtggatgtc gagcatgccg ccctgaccgc gcgcgcggcg
     4381 cgacgattca cgttcataca cgacggcgtc gatgccgttc acgtgcagca cacgggcgag
     4441 agccaggccg ccgaggccgg ctccgacgat ggcgatggtc atggttgccg ctccttcgat
     4501 acaccgtact ggtcgataca ctgtatcgac cgatgcgatg tattgttggc ggcatgttgg
     4561 tgtgggagag gcctgagccg ccgaaccgac ccgtgccggc cccgctgaac cgggagcgga
     4621 tcgtgcgggc ggcgatccgg ttggccgacg cggacggcct ggaggcggtg tcgctgcgca
     4681 aggtcgccac cgcgctgggc gtcgggccga tgcggctgta cagctacatc gccggcaagg
     4741 aggagttgct cgacctgatg gtcgacgcgg tccacgccga gatccggccg gtcggagacg
     4801 actggcggga ggtgctgcgc tctcttgccg agaccacccg gcaggccgct cacgagcacg
     4861 aatggctcgc ggatctgctc ggtggacgac cgcagctcgg gccgcacgcg ctggccaggg
     4921 gggaggccgt cgtggccgcg ctggacggcg tcgacgtgga cgacatcatg ccggtggtca
     4981 ccgcggtcga ggcgtacgtg atcggcgcgg tgcgccggga gatcgccgag cggcgtgccg
     5041 agcgggccac cgggatggac gagaagcgtt ggcaggcctc actcgggccc tatctggaac
     5101 gcaccttcgc caccggccga ttccccgcgc tggccacggt agtgcgcgac gccgcccacc
     5161 tggacgccga ccacaccttc cggatcggcc tcgacttcct gctcgacggc atcgaagccc
     5221 gcatctcaag gtgacacacg gctgaccgga cccccttgtg gtgggcgcgg ctgtcgtttt
     5281 tggtgcttcg cactcggcgc gcgccgtctc ttcgcacccg gccgccggct cgcgccgtac
     5341 cgcgcgcccc ggtggtgccg cacgggccgg agccgtcagt ctccacgcca ccgcgagttc
     5401 agtcccggca gccggtctcc atggcttcgg gcccgggaga gccctgggcc gggtagaact
     5461 gttcggccca cttgcggaac cccccgatcg ggccgtcacc ccgcgcgatt ctgggcggat
     5521 tgatgtaccg cttgccatgc caaatgggca cgtcctgagt cagaagtcgc ttggccgagg
     5581 caagtcccag tccggaggcg gcctctgaca gtgcatcggt caccgtcctc gggagccgac
     5641 tcagcggcgg tcgggccgcg tccactgtca ctctggttcc gaccaacatc tccgattgcc
     5701 acggcgccag ggcgcggatg ccgaccgcga tgtcgtgctg cagacggtac tgcggcacac
     5761 ggaacaccaa atggtagaaa cccagaccgt agaaggaaat cgctccctca gcgaggaccc
     5821 tcccaaaggg agtcgcctgg gtcaggtgca ttgtgtacga gtaccggtgc cggtccagga
     5881 cgggctcacc gacgcactcg gcctcggcga aagcatgcag ggcctgctga tggcgcagat
     5941 ccacgccgtt ctcggagatt tcctggggat gggtccccac ttggatacgg gcgaacttca
     6001 ttcccgttgc ttccagcacg ggcgggatcc gccagtgagg cgcctcgccg gcgtctgctc
     6061 ccacccagac gtagatccct ccattgactt cttccgacgg cagcaagagg agtttgtccc
     6121 gcacgggttg ccctgtatag ccgggaccca cccgtgcgac cgcaccgtcg aggtcgaagg
     6181 cgaaccggtg gaacgggcag acgatgttct cgccgtccac ccatcccccg cagcccagat
     6241 gggtgccgag atgcgggcaa tacggcctca cgacgttcaa tcgaccgctt tgcgtccggt
     6301 agacgacgac gtcctcgccc atcagtctca acgtcagaac cgcgccgggt ctcacgtctc
     6361 gcgacggagc gagcatgaac catcctgtgg gatatggaag aggcgcattc ccatcgccat
     6421 agggccgctt cggattctga ctgcgggagt gccgatgcca tcgcgccatg ggacgtcatc
     6481 ccttctacac atatcacccg gacgccggcc gtatcaccca gggccccggc ctccccggtc
     6541 ccgacaaaca ctgcccactc tggcagacgc ggtcccagac gcggaaagcg atgagcggac
     6601 agtagcccgg tcggcttact catcgtcagc aaccgaagaa atccggggaa acggaaacgg
     6661 aagaatggcg tgcgttgctt ctccggggat ccgcccggcg accggcctgc ctacggccgg
     6721 gcaactcgac tggtggaagg aatcgcctgt gaccgggacc cccgaaccct ccgtccgcga
     6781 cacacccact ccgcccgttc ccccggatac gtcgaccggc acccggctgc ccagcacgct
     6841 ggtgcgccac ggcttcagcg tcctggttcc gttgctcctg cccgtgggca aggcgttctc
     6901 cctcgcgcgc tccacgtacg ccgcctgccg tcgggtcctg cgccgccgca cgccgcacga
     6961 ggagcggatc gcgaggctgc agacgaccgt acggcgactc gccggtgagc gggcggggcc
     7021 gctgtgcacc ggcaccaagg agtggcagtc ggtgtcggtt ccccgtgaac actcctacaa
     7081 gcggagggcc cgccccgtcg gactgggcct cgacgccatc ctggagctgg acaccgagcg
     7141 ccgggtcatc cgtgtggagc ccggcgtcac catgggacgg ctcgtccgtc acctcgttcg
     7201 ccggggctgg accctgccgg tggtgccgga actcgaagcc ctcacggtgg gcggcctgac
     7261 catgggtttc ggcatcgaga cctcatccca ccggcacggc ctcttcgccg acaccgtgga
     7321 gagctacgag gtgctgctgg ggacgggcga ggtggtccgg gcctccgcca cggaacacac
     7381 cgatctcttc cacgcactgc cctggagcat gggatccctc gggttcgtgc tcgcggtcga
     7441 gctccgtatc gtcccggccg ccgcatgggt cgaggtgcgg taccacccgg tggccgacct
     7501 gtcggacatg tgccgggaca tcacccgcct cgccgaccgg gcagacggtc ccgcgttcgt
     7561 cgagggtttc gtctacgggc ccgatgaggg cgtggtcgtg accggggaat tcaccgaccg
     7621 ccccacaggg cgacaaaacc gcgtctgccg ctggaacaag ccgtggttcc acgcctacgc
     7681 gcgagactgc gcgcgggccg gcggccgcgt cgagtacgtc ccgttgaggc agtactacca
     7741 ccgtcacagc cggagcctgt tctgggccgg cgagctgctg gtcccgttcg gcaaccatcc
     7801 gctgttccgc ctgccgttcg gctggctgat gtgtccgagt atcgagttcc tcaagctcat
     7861 cgacactgat cggaggcgcc gccacacggt cgcgcaggag gcgcttgtgc ccgcgcgcca
     7921 tctggagggc ctggtccggc actgtcacga ggtcttcgag gtggacaagc tgtggatctg
     7981 tcccgcacga ctgacccgtc gcgagccacc gggtctggtg ggcccgggcc ccgacgtcgc
     8041 ccccgggcag gggatgctgt tcatggacgt cgccgtgatc catgacgtgc caggtccggt
     8101 acggcgggga gagccgtggg atcagcggga ggccacccgc cggttcgagg catgggtggg
     8161 cggacacgac ggattccagg cgccgtacgt actgtccgag ctcacgcgcg aggagtaccg
     8221 cgcgatgttc gactgccgac tgtacgaccg ggtacggcac gcctacggcg gcgagggcgt
     8281 cttcgtggat gcctacgaga agatcacctc cggctgggcc atggcgcccg gcaagtgatg
     8341 ccgtattcct ggtacatgcc gacggcgaag gggccggtac cgataccggg ccctcacact
     8401 cggcggaagg cacgcccctg caccacccgg ccgtagaagt tgaaccaggt ccgtgcctcc
     8461 tgatcgtcgg ggaaggggaa ctccgccccc agttggcggg cgacgctcag ccctgagacg
     8521 agcgccagtt cctggctgtt gaccaatgtg tgtgctccgc agtaccacgt gcgccgtctg
     8581 ccctggaggc gggggaacag gggcatgagg gcattcatgt gccgcacgtc gtaggccaca
     8641 tgctggaacc actcccgggc caccacggtg tccgggtcga cggggcgctc cgggttgtag
     8701 gtgaccagac agtgacggcc tgcctcccgg atccagggct gctggttgtg catcaggtag
     8761 gtgatctcgt agttgtccgg gcgggtcccg tactggcgga tgaagttgga gcgggtcgcc
     8821 agcatctcgt cggcggcgtc ggccgggagc acggatgtat cgccgtgcac caccgcgtgg
     8881 ttgtgcagct cgctgttgta gcggaccctg cccagcagcg cccgttccca ggccgaggga
     8941 cggtccagcg ccagaagcga ctggttggcg ttgcaggcca tcacgaccgt gtcgaaccgc
     9001 tcctcgcagc cggcggcgtc gcggatcgtc acgccgtgtt cgtcgcgcag taccgcggtc
     9061 accggtctgt ccaggtgcac ccggtcctgg aagccggcgg tcatcttccg gtagatctcg
     9121 cgcgtgcctc cctgccaggt catcatcggc gtggacgcct cgatgtcgaa gaagtcgaag
     9181 tagcggcaga acagtgcggc gggcatctcg aagatgtcgg tggccagtac gaagttgacg
     9241 ctgatcggct tgaggatcgc gtagcggaat ccggtggaga tgccccacca gtcgagcacc
     9301 cggcgcacgc tgacgtactg gaagggattg gccgcggtgg ccgctcggga cggacgcttg
     9361 ctgagggtgt tccaggccct gagcacccgc agcatgcgca ggaaggcatc gagatcccgg
     9421 cggtagcggc gcttcagggt gctgtccgtg tcgtgtgcgt actcgctgcc ctggtactcc
     9481 acggcgtagg agaaacgggt gggcacggcc tcgatgccgc accatcgcag cagcgcggcg
     9541 aagttgtgat acacggccgg gatgaaggag gtcacggcca tgtcgaccgg cagatgtgac
     9601 ccgtcctcca tcggcaggtc gacggtgcag ccgttgcctc ccaggcgccc cttggcctcg
     9661 aacacgtgca cagtgaactt ctcggggtgc cggtccagtg cccaggccgc gccgagcccg
     9721 gccattccgg caccgaccac gcacacccgc agcggtttcg tcactgttcc gtctgccttt
     9781 ctcgtgcaag gacgatgtgt cggcgcgtcg ccgttccggt catgcgtttc gtggcgggtg
     9841 tgggaagggc tccttcagtt gtcgcgcagc gggcttcctt cgtctgccgg tacgagcgga
     9901 cgcagaccag gtcggcagcg gcacatgcgg gcactgcggg gcgctgcggc accgagcggg
     9961 accagcttgc cgtcggcctt gcccgccggg cggacggtgt ctatgacgcc tcccgggcgt
    10021 cgagccaacg ccccagcgcc cagagcggga agtaccgggc gtagagccgg tagtcgagca
    10081 ggcccgtgcc gaagaacacg ccgttcaccg acgtctgctc ccatgtgccg tctggacgct
    10141 gggctcggca cagccagtcc acgccacgga ccacgaccgg gtccttcgga ccgccggtgt
    10201 ccagcagcgc gagcagggac caggcggtcg acaccggctg gctgcgtacg tgctcggcgt
    10261 accggttctc ggtgcagccg cgatggtgtt cgccccagcc gccgtcggcc cgctgcacgg
    10321 cgcgcagcca gccggcggcc cgccgcagcc ggggatgatc ggcgggcagt cccgcggcgc
    10381 gcagcccccg gacggcgaac caggtgccgt agatcctgtt gacgccccag gcggcgggcc
    10441 acgagccgtc cgcctcctga cggcgcagca gaaacgcgac agcgcgccgg caggaacggt
    10501 ccacggcgga cgagagcggg cccagggcat gcgcgggcag cgcggcgaag gcagtcagtg
    10561 cggaggcggt gcactccaca taggagccct cgaccatgca gtccgagaac atttccgagg
    10621 ggttgagcgc ctccagccac cggccgccgc gccggcgctc gtaggtgccg aatcccccgt
    10681 cacggttctg ccgctccagc aggaagcgca ccgcatggcg caggttctcg tccggcaggc
    10741 ccccggcccc gggcacggcc cgggcggcat gggccagcgc ggcgagggcc tctgccgtgc
    10801 agtcgctgac cggccagcgg tgcccgccct cggagaagca ccagccgccg agggcgggcg
    10861 agcgcgccgt gaccgtcggc tgggggatct cctcggtgac ctgcgcgccg cgcaggaagg
    10921 cggctgcccg gcgcaccgcg tcggcgacgg ccggttccgg ctcgtgcccg gcctggccgg
    10981 cgaggagcgc ttccaccgcg aatcctgtgt cccaggtctg ggaacgggcc cccgcgtagc
    11041 gggtgccctc cgcctcgtcg gtccagcgcc agtacgcctg ggcggccagt gcccgggcga
    11101 cggctgcgga tcccggccgc gccgcatgca gcaccagcac gttgagcagc gcgttgacgg
    11161 gcgagagccc cagttcgccg gtcaccagct gttcgtgctc cactcgccgc aggcatcggt
    11221 tgagggcgcg tcggcgcagc agcggagcgg gccgcagctc gtagccggag agcatcgcgt
    11281 tgaccgcgtg cagcaggggt cctgccggac ggtggatgtc cgtgccggcg caacgccgct
    11341 cgcgcggcag cgtgtccgag ccgaacagtt cgtgccgcag ctgggcaccc agcgggccca
    11401 ggtcggcctg gaaacgggcg ccgtagaggt aggccatggc ctggtagacg gaacgggtgt
    11461 ggcagtagaa ccggttcgga tgcaccggca cccagcgcgg cagcaggaac atctcgggcg
    11521 gaacgggatt cacgccccgg tagtcgtaca gtccggccag cgccagccag aacttgcccc
    11581 aggtcggcac cgcgcggggg ccgccgggca gggtacgcat ccactcggcg gcgccgcggc
    11641 acagcgggtc gtcggcgggt acgcccagca gacgcaacgc gacactcgcg agcaccgtgc
    11701 agtagaggga gggatgtgac gactccgagt gcgggcccca gccgcccttg ccggtcaccg
    11761 tggcgcggta gtgccggatc atcgcctcgc gttcgtgctg ccgcggcgga ttgccggtga
    11821 cggcgcagac gatgacgtac tgggagagga tcatggtgtt ccacaccatt tcgccctccc
    11881 agcagccgtc cggccgctgt tcggagacca gccggtcagc cgcgcggcgg tacgccgtcc
    11941 ggggcgagag ggccggcggg cgcggggggt gcggaagatc ctccggcgcc actggatctc
    12001 cgacggacac tggtggcttt ctctcgctca aggtactgct cccacttgcg gatggtgagg
    12061 tcctggaaga ggtgcacggc ggggttcagc tcgacaaggg gagaggcgaa gttccgttcg
    12121 tagccttctt gttccgcttc caccgcggtg ccgtcctggc gcagcagcgg gcggacggcg
    12181 agaactgcgg cggctttcat cagcggcccc atcagcggcc ggggcacgcg cgcccgggtg
    12241 ccggggatct tcagcgcgtc gaagtagaag aggaagaaga cccgcgtggt cgtccggtcc
    12301 atgggcagca cgaaacacca gtgcttgatg gcgcctccgg tgtccgaccg ctggtaggga
    12361 tactcgtacg cgaggtcgat gctcgtggtg tccacccgac gccggtccac gaaacgcccg
    12421 gtcagacgcc cgccgccgat caccgtgtcg taactgagcc gtacggtgtc ccccactgtc
    12481 tcgcagtgcg tcaaccgggc gtcccagaag ggtcggtact tgcggtgcag ataggcgtgg
    12541 gtgaagtcgc tgacgttgtc gatgatcatc gagtggtgcg cccgccaggt gtagtcggcg
    12601 tcgatccgcg cccagggccg cggtccgtcc agctccggaa tatcagggat gcgccgtccc
    12661 tgcgccagcg tcgggtcacc ggggaagagc cagatcaggc cgtggcgggc ggtcaccgga
    12721 tagctgcgca ccttgacctc gggctgggca cgcccgaaca ggtcgtgggc gtagtgcacg
    12781 actctgccgg tgccgtcgta gctccagccg tgatacatgc acgtcaggtg gcagccctcg
    12841 acctgcccgc ggctcagggc gagttggcgg tgcgcgcagc ggtcctccag cgcccgcagc
    12901 gtgccgtcct cgccccggta cagggcgatg tcgcgtcccc agaaacgggt cccgaccacc
    12961 tgaccgggcg tcaccgcgtg ctcgtactcg acggcgtacc agtagtcggg gtccaggccc
    13021 gcggcacggg ccttctgccg cttgttgcgg gcatcggcga agtccggggg gccggcggcg
    13081 ggccgtccgg caggtgtggt cggtcggtcg gagctcaaga gaaggcctcc gcggtacggc
    13141 cggggcggtc cagggcggga catctgcggt aacggatcag acagggggac cggggagccg
    13201 gcacgaacgt cgagtagtcg ggcgggtgcg gccccgcgcc cagccccagc tcgtagcggc
    13261 gcagcagcac gctccagatg gccttcacct gctgataggc gaacgccatg cccacacacc
    13321 ggtgcttccc gccgccgaac ccgatcaggg cgtagggcac cgtgtgctcc tcccggccgg
    13381 gcgcgtaccg gccggggtcg tacagatcgg ggtcgcggaa gacttccgga agccggtgcg
    13441 agacagccgg ggagatcatg accagggttc cggcggggac cacatgccgg ccgtaccgga
    13501 agtcccgcag tgccttgcgg atcagcacga ccagcggcgg gtgcaggcgc tcggcctccc
    13561 ggacgcacca ctccaggcgt tccatacggc gcaacagcgg caccgtgagc gggccacccg
    13621 cgccgacggt ctcccgttgc tccgcgagga gtgggggcag atggccgggg tgagagagca
    13681 gcagcacgcc ggtccaggcc gcgaggacgg cactcgtgtg ctgaccggcg aagatcatgc
    13741 cgatcagcag gccggtgatg gtctcatcgg gcagtggatc cccgtccggg gtgcgggccg
    13801 agagaagggt ggccagcatg tcctcgggct cctcgccgcg cgtggcgccg gagagccttc
    13861 ccgcggcacg gcgttcggcg atgacctcgg cgagcgcgcg gccgatggcg gcgcgtgccc
    13921 ggtcccggcg ccggaacgcg ggcagcggca gaccggggtt cagcagcccg gccagccgga
    13981 tcccggactc caggtcccgg tacaggcccg gcaggtccgg gcccaggcgg cggctgacct
    14041 cggggccgag cagacagcgg gtggcgatcc tgacggtcag ttcgttcatc gtcgcgacga
    14101 ggtcggccgt accgctctcg ccccaggaac cgaaatacgc ctccgtctcg tcttccatga
    14161 cctgtgcgtg agcagccagc cgacgcgagg tgagagcagg cagcagatgg ccgatctgac
    14221 ggtccatctc ctccggctcg gcgtcgtagg cgaccccccg gccgaaaacc ggcgtcatga
    14281 agcggtacgc ctcccgggga ctgagcaccg cctcgtcggc gcggaagacc gcctcctgcg
    14341 cggccgggcc gcacaggaag accacgggct gccccagcag ggtgaaggcg aagacgtcac
    14401 ccgcccggcg gcgggcgcgg cgcaggaagt cgaccgggtt gtgaccgaac gggagggcgt
    14461 gccccaccca gggcaggcga aagccgccga gccgaggcgg cgcctccggc cggtccaccg
    14521 atggcccgcg gacgagcccg gtcaccgggc gctcgccgcg accgactgcg cggcggccgc
    14581 ctgcctgccg cttcgggacg tgaccgcgat ccgccgcccc ccgctgatca gacggcggcg
    14641 cacgaaacag tcgtacgcct gctccacggc cgtggcgatg ctggtgggcc ggtatcccag
    14701 ttcgtcggcg gcccgtgagc agtcggcccg ccgctgcgag cgcaggaacc gcacggccgc
    14761 cggcgtgaag cggcccggcc ggtgcggagt cagtacggcg cgcaggggct ggaccagttc
    14821 cgcgaccccg gccatcaccg caccgggcac ccgcagcgac ggccggggcc gaccgcagac
    14881 ggcgctgtag agatccatca tctcgtcgac cgtccggaac tccgtggaca gcaggtactt
    14941 gcgcccggcc ctgccgtgcc gcatggccag gacatgcccc tccacgacgt cctgggcgga
    15001 gacgaactcg aaaccgcccg gcacataggc acgcaaccgg ccctcggcga agtcgagcag
    15061 cacccgcccc atccgcgacg gccggtagtc gtgcggcccg atgatcgcgg tcgaggcggc
    15121 gatcaccacg tccaggcccg aggcagcggc acgcaggcac tcgtgctcca ccaaaacctt
    15181 gctcacggtg tagggcgtgt gcctcgcgaa cgggtagaac ggcatgtcct cggtgctggg
    15241 gcggccgaag gccgtttcgc ccgtggcgct gaacgacccg gtgaccacca cccgagcgac
    15301 ctcgtgacgc ctggcggcgt ccaacacgtg gcgcgtgccc aggacgttgg tccggtagat
    15361 gtcccgcttg ccaccggagg tcgtggagac ctgcgcggca cagtggtaga cgcggtcgca
    15421 gccggccacc gcccggtcgg tcgcggccgg gtcgcgcagg tcgccgaaga cccgctggac
    15481 ggcgagccct tccagggcct ccggctgcgt ggagcgctca ccggagatca gcactctcac
    15541 ctcctcaccg tcatcgagca gccttcgcac gagattggcg ccgaggtgtc cgctgcctcc
    15601 tgtcaccagt agcacgggcc gtccccttat gatctttcag gcatgagtga ctaattagct
    15661 gaaaaggaat gcggatgaac ataatgcgct agtggttccc tcgttgccct gacgactcgc
    15721 ctgctgcccg gctgatcgga cgagaccgtc cgccccggcc gaaaaagaga ggagacacgg
    15781 tggactccgc cgatgtcgtc gtcgtgggcg cgggaccggc cggttgtgcc tgcgctctgt
    15841 ccttcgcccg ccggggagtc cgggtgctgc tcctggaagc ccgacgggct ccggtccacc
    15901 gcctggccgg agagtggatc cagcccgccg gtgtggccgc actgcgtctg ctcggcgtgg
    15961 acgtgcaccg ggacgggccc ggaacggcca aacgcggttt cgtcatgcac cccggggacg
    16021 gcagtgcacc gatcgccctg cccttctcgg cgggcgaggc ggtgagcctg ccgcacgccg
    16081 agctgaccgc gctgctgcgc cgggccgtgg ccgaccaccc cgccgtcgag ctgcgcacgg
    16141 acgtacgcgt cctgaccgcc gaggcgtccg gcctggtgcg cacctcccgc ggttccgtgc
    16201 acggggaact ggtcgtaggc gccgacggcc gcgcgtccgt gatccgcgcc gcgctccgcg
    16261 ccgagcgggc ggaccgtacc cccttctcgt acacggccgg attgctgctc cccgacgccg
    16321 ccctgccgcg cgagcggtac ggccacgtca tgctcggtgg tccgggcccc gcactcgcct
    16381 accgcctcaa caccggcacg gtccgcctct gcctggacgt gccaccgggc cggccgtcag
    16441 ccccggcgct gcgttcctac ctgtggcacg gctacgccga ggcgctgccg gcctgcctgc
    16501 gtacggccgt ggcggagcag ctgcgggccg ggcgggtgca atgggcagcc aacctcttcc
    16561 agccccacgc cttctacggc agcggtcgcc gcgccctggt aggcgatgcc gccggctgcg
    16621 tccacccgct gtcggcctcc ggactcacct ccgccttcct ggacggggag tgccttgccc
    16681 gctcagccga cgtggccgcc tacgccaggg aacggagtgc cgcatgccgg gtttccgacc
    16741 ggctcgccgc ctgtctgcac cgcattctca ccgaccgctc ccccgccacc cgggcgctgc
    16801 gggaggccat gttcaccgtc tggcgtgaag acgagcggcg aagggaccgc atgctgcggc
    16861 tgctggccat gacggaactg cgccggcaca cgttcggcac cgcgttcctg cacgtgctgg
    16921 cccgcgcgct gtcctcgtcc gcacggaagg cggtcatcga cggccagtgg acggaggtcg
    16981 cccgggaact caccggattc gccggctggc tgcaatggat cgcccagttg cgggcggggg
    17041 ccccggcgtc cccggccggt gtgcaccgcg ccctggccct tctcgggccg tgacaccgtc
    17101 gtcctgagcc tcaccgcgga acctgcggag gatcgcccgg tacgcgtacc aggccaggag
    17161 cagattgccc agcagccaag ggagattcgg cacatagaag atgaagtagt tccacgcccc
    17221 ccgctcgggc atgttctcgt agccgccgac caccgcgcgc cagaagtaca ggacgaccga
    17281 gtaggcgacg tacgaggaga ccgccagctg gagcgggtac cggtagggcc ggttgcgcag
    17341 gacaccgacg gtgatgccca ccgacagcac ctgggtcacc gtcagatgga tggtctccag
    17401 ggcgaacggg aagtacacgt ccccttcccc cgcataggcg ctgtcccccg ctccgtagac
    17461 ctggaagagc cgggcgaaga cgtcgcgccg gccaccgatg tcctggaagt gcaggacgaa
    17521 gtacaactcc aaagtgaacg cgagaaggaa ggagaacgcc aggaacccca gcgtgatcct
    17581 gtcctcggga ctgcgacggc ccattcgctg ctcctcaccc ggtcggctcc ggtggtctgt
    17641 ggcaggagaa ctggacaaag aggctcagta cacgaaggga accaggcggt atctgacctt
    17701 ccggcagtac cggtcccaca gttcgccgta cttggcccgg cagcgacggt cgtcgcggcg
    17761 cgcgcggtgg acgaagagcg ccgacagcca cagcagcacc agatacggca gcatcgacga
    17821 ggctccgcag agcgaggtcc aggccgcgta gacgaggaac tcgccggtgt agttgagctt
    17881 gcgcccgatg ccccagaagc cggataccag cagccgcccc tccagggttt gcgccggacg
    17941 cccccagatg tgcgtggcac cgctccgccg gaaccggtgc ttctgcgcgt tcgccccccg
    18001 gaagacccag aagcccagca ggaaggcact tgtcgacagg agggcctgac cggcccccag
    18061 cggcgccgac acgtcgatca ggacgtgtcc cggcaggctg tagaagaagg ggaccaggac
    18121 gaggtcgccc cacaccagca tccagccgaa gcgctcggac atgacgtccc aggtgaagag
    18181 catgccttcc tcgaactgga agaagttcgc gatgtagacg aagaacatca cctggtagag
    18241 gatcatccgc tggctcaagg acccctgctc cagcccctgg gctgccgcac aggacacgtt
    18301 gaacaggaac agcccgatga gggaggggcg gtacgcgaac atcttcagat cgacgccggc
    18361 cagtttgggg ttgagccgca cccccaggaa gcagtccacg gccgccgacc gcgcaccggg
    18421 tccgcggcgc tgcctcccgt ccgcccacag ccatacggcg gcgatcaggc tgaagacgtt
    18481 ggcggccacg aacagcgcct gccagtgccg gaccggatag gccagggccg tcggccggac
    18541 cagcgcggtc accagcaccg ccagcacgca cagcgagaag agcagcatcc cgttgagccg
    18601 gtaacgctcg cggctgccgt cggcgagggg ggcaccttcg gcccaccggc caggcaggca
    18661 gcgtgtaccg aggaacagga ccaccatgaa cgccgtgaag aacacggcgg cggtcagccc
    18721 ttccccgagg acggcaacca cgatctcgca cctcgcagac acctcgacgc ggtgatcacc
    18781 tgagaacgga cgctcgacgc gccggtcggc cgcatccggg gagaccgggg ccggccggaa
    18841 cgccttcgcg gatcacgccg gtttgcgtgc ctcccagtaa ccgacgagaa acgctccctc
    18901 ccgggccgcg gcggacagca cgcggatccc ccgctgcatg aaccgcagca gcggtgtgac
    18961 gtcgtcgctg tcgtcgagca gatcggccgc ctcgtcgagc atcagccaca cgggttccag
    19021 gctgccctgc tccgaggcgt cggcgacccg cacgggatcc agcccggcgt cgcgcagatg
    19081 gccggcgagg gtctggggcg tggagaggtg ggtcaggcag tggtggcggc agatgggttc
    19141 gatgaaccgg gaggtctcct cgtcaccgag gccgtcggcg gccagccagt cgtacccgag
    19201 atagacgcct cccggcttca gcaccctggc ggcctcacgg tgcacccgct ccttctccgg
    19261 catgtggacg atggagtcga agctgtagac ggcgtcgaac gagccgtcgg gaaacggcat
    19321 gtccagcgcg tcgccctcga cgaagtccgt ctgtgcggtc agtccctgct cggccgccct
    19381 ggtccgcgcg cactcggacc gcacaggagt gaggtccagg ccggtcacat gggcgccgga
    19441 atgcgccgcg atggtcaggg cggggccgcc caccccgctg ccgatgtcca gtgcacgggt
    19501 gcccggccga agcccggccc ggtcggccag tcggcactgc gcggtccgct gcgcctccgc
    19561 gagggactgg ccgtccgaga agggcgggaa gtggtgcgac tccccccagc ccgagcggta
    19621 cacgtcgttg acgagctcga agtagctcgt caccatctcc acgtagttcc gctcgcggct
    19681 ctcccgttcg gaaacgactt cctggattct cgccaatcgg gtcgcttcac tgctcaaggc
    19741 tgatattcct ctcgactgtg acgccgtcga cgggctgcgc cgccgagtag aactggcgtg
    19801 cccaacgccg gtagagattg atcggtccgt ctccttgcac aaggggcggg tgcgggatgt
    19861 agctcttgtg ggcccagacg ggcacgtcaa gagcgagctg cgaggtgaac gccgggcgcg
    19921 ctgccgcggt gagcagggcg gcgagggaac ggaaccggcg cgacgtgggc gggaacggct
    19981 tgccacccgc atcgggtcgg gcactgacac gggcacgcaa ccgcacctgg tgcggcccgg
    20041 tggcagtcct ggtgacgaga cttcgcaacg tgacgccgag ctgaggaaag tacgtgtcga
    20101 cgacgttcag gcccaggccc cacagccgcg tggtgatctc cattcgcagg agcaggccgg
    20161 gaggaaaact cttcaccccg gcgagcgcat agcgtgcctg gtgcccgtcg ctggagaacg
    20221 actcgccctc ctgtacgtct gtcaggccgt ggatgtaccg gaaatgcccg aggtcgatcc
    20281 cgttctcgac cgtgtcctgc ggatgggtgg caagaagacg cgaacactgc atgacagacg
    20341 ggaaggactc catcaacgcc gacggaacct cccactgcgg aggcactccc cgcgcgctgt
    20401 accagacgaa gaccagcccg ttggcctccg tggtctccca ggtcccgaga cggactcgcg
    20461 gaggccgcgt tccgtatccg gttgccacac aggcgccggt ccggtcgaat gcgaacccgt
    20521 gaaaggggca gaccactcgg tcacccacca cgcgcccgcc gtaccccaga tgcgcgccca
    20581 gatgcggaca gtacggtgtc acggcctggg ccacaccgtc gcgtgtccgg aacagcacga
    20641 cgtcctcgtc catgaagcgg gtacggatca cctttcccgt cccgagttcg ctgccgaacg
    20701 cgaccgcggc ccagccgtcg ggatacggga gaggcagttc cttgctcatg gaagccacgc
    20761 gagttgacac ctccggttgc gcacagcacc aggggcaagc atcacggagc ccttgaccac
    20821 aaccccggcg acacgctcac cggccccgtc cgggtggccc atgcagacgc ccggcggtca
    20881 ccgtggaaga gcacgccatc ggcaccgcgc cctcggtacc ggtccgagcc ggacagatgc
    20941 cgccgcatca ggcacgatgg cggcaggccg gcggcgatct gagcttgacg gtccaccagc
    21001 gcccgggaca gcgccgcgtt cctggagcgc caacgcccgc gccgcggcga ccgggccccg
    21061 tccatggcgg agcccggcaa ccgagcttag ggacccgcct tcgctgattg aactgcagcc
    21121 gacggcagac gggctggcgc accatgtggc caggtccttc ggaagtctcc acatgcaggc
    21181 cgtggagggg cgaggatggt cagcgtggag aacatcggca cgcgggggtg agtgatggag
    21241 gctgctgacg tcatcgaagc gctggagggg ctgcgggggc cccgggctgt cgtgacggca
    21301 ggccaggtca gcgtgtacgt ccccgccatc gatgacactg tgcgtatcga cgtcgccgaa
    21361 gtgaggcggt acaagcgcat ctgggccccg aacggggacc ccgccgtgga gttcgtgatg
    21421 ggcgacgagc gggaagtgtg gccgctgatc attacgcctg acgacgtggt ctgtcgcccg
    21481 gtggacacgg gcgccgtcct cgactcctcc attgagttcc ggatcgccaa tgccccacac
    21541 atcgtcgcct acaccgagat ggagcgcgcg gccgaacagg cggccttggc ctgcgagcag
    21601 ccggagccga tcgagctcga cggcgcagga gccactctgt tgctcgtgcg gtgctccatc
    21661 gtcgcggcca cgctggccgg gctgcggccg gtgcgcagcg tggcgtggtg gcagcgtgcc
    21721 tgggccgccc tcggcgcaga cgtgccgctg ccgccgttcc gggcggaccc ggtgtgggac
    21781 gagctgatgc acgaggcgtc tcgactcacg ctgacagcct ctgcccgggg agaaggcgac
    21841 ggtccctcgg ccgccgccgg tgtggccgtc tccgacttcc gtcggctggc gccgaggctg
    21901 accgctgtgg cgctggacga ggagttcgtg tcgtgctggc gggcctcgat gccgctcacg
    21961 ccgacacggt tcgtcgagac gctgctgaac ggcctggacg cggcgcgggc
//
