LOCUS       NZ_KQ947989            21008 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s006, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ947989
VERSION     NZ_KQ947989.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 676431)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 676431)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 141966
            Orig. end                         :: 162974
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ947989.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(1258..1272)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.71"
                     /tool="antismash"
     gene            complement(1777..2640)
                     /locus_tag="AQI70_RS20900"
                     /old_locus_tag="AQI70_20895"
     CDS             complement(1777..2640)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-265). E-value:
                     1.6e-27. Score: 88.6. Matches aSDomain:
                     nrpspksdomains_AQI70_RS20900_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003898.1"
                     /locus_tag="AQI70_RS20900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20895"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_062152320.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-24, bitscore: 82.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.8e-18, bitscore:
                     61.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFTASDGTEIAYHLRGEGEPLVVLPGGPMQASAYLGDLGGLAA
                     HRQLVLLDLRGTGDSVVPADAATYRCDHLVDDVEMLRAHMGLAHMDLLAHSAGGSLAML
                     YAARYPQRVARLALVTATPWALGMPPTAEDRLAAARLREGEPWFAETFPVFEAWLEGRG
                     DFEPALAPFFYGRWDDVAREHHARGDDQFNDEAGDVYGSDGAYDPPATRDALSRLTAPV
                     LVLAGELDGSPRPETAHRTADVFPHAEVAVQPGAGHYPWLDDPEWFVGRLVAFLSGRRV
                     PPAAVR"
     aSDomain        complement(1846..2577)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS20900_Abhydrolase_1.1"
                     /evalue="1.60E-27"
                     /label="AQI70_RS20900_Abhydrolase_1.1"
                     /locus_tag="AQI70_RS20900"
                     /protein_end="265"
                     /protein_start="21"
                     /score="88.6"
                     /tool="antismash"
                     /translation="PLVVLPGGPMQASAYLGDLGGLAAHRQLVLLDLRGTGDSVVPADA
                     ATYRCDHLVDDVEMLRAHMGLAHMDLLAHSAGGSLAMLYAARYPQRVARLALVTATPWA
                     LGMPPTAEDRLAAARLREGEPWFAETFPVFEAWLEGRGDFEPALAPFFYGRWDDVAREH
                     HARGDDQFNDEAGDVYGSDGAYDPPATRDALSRLTAPVLVLAGELDGSPRPETAHRTAD
                     VFPHAEVAVQPGAGHYPWLDDP"
     misc_feature    2789..2805
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            2908..4215
                     /gene="paaK"
                     /locus_tag="AQI70_RS20905"
                     /old_locus_tag="AQI70_20900"
     CDS             2908..4215
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (83-335). E-value: 3.9e-22.
                     Score: 70.3. Matches aSDomain:
                     nrpspksdomains_AQI70_RS20905_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003897.1"
                     /locus_tag="AQI70_RS20905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20900"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_062152322.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-28, bitscore:
                     94.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDATELLDSGERLDAEALRALQLERLRTSLRHAYDNVPFYRESF
                     DKAGVRPDDCRSLADLARFPFTTKADLRENYPYGMFAVPQDRIRRIHASSGTTGRPTVV
                     GYTEADLSLWSDMVARSIRAAGGRPGDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPAS
                     GGMTARQVQLIQDLRPEIIMVTPSYMLTLLDEFERRGVDPRGTSLRVGIFGAEPWTERM
                     RAEIEERFAIDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFLPEIVDPISGEVLPD
                     GEKGELVFTSLTKEAMPVIRYRTRDLTRLLPGTARVFRRMEKVTGRSDDMVILRGVNLF
                     PTQIEEIVLRTPGVAPHFQLRLSREGRLDALTVRAEARPNAAPESREAAARAIAAAVKD
                     GIGVSVGVEIVDPESLERSVGKIRRIVDERPDRARG"
     aSDomain        3157..3912
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS20905_AMP-binding.1"
                     /evalue="3.90E-22"
                     /label="AQI70_RS20905_AMP-binding.1"
                     /locus_tag="AQI70_RS20905"
                     /protein_end="335"
                     /protein_start="83"
                     /score="70.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="PQDRIRRIHASSGTTGRPTVVGYTEADLSLWSDMVARSIRAAGGR
                     PGDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDLRPEIIMVTPS
                     YMLTLLDEFERRGVDPRGTSLRVGIFGAEPWTERMRAEIEERFAIDAVDIYGLSEVIGP
                     GVAQECVETKDGLHVWEDHFLPEIVDPISGEVLPDGEKGELVFTSLTKEAMPVIRYRTR
                     DLTRLLPGTARVFRRMEKVTGRSDDMVILR"
     CDS_motif       3880..3942
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS20905_0001"
                     /evalue="4.70E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="AQI70_RS20905"
                     /protein_end="345"
                     /protein_start="324"
                     /score="13.0"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     gene            complement(4279..5778)
                     /locus_tag="AQI70_RS20910"
                     /old_locus_tag="AQI70_20905"
     CDS             complement(4279..5778)
                     /NRPS_PKS="Domain: AMP-binding (13-404). E-value: 3.5e-98.
                     Score: 320.8. Matches aSDomain:
                     nrpspksdomains_AQI70_RS20910_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069067.1"
                     /locus_tag="AQI70_RS20910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20905"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_062152324.1"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-100, bitscore:
                     331.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAHGSTVDGVLRRSARRTPARVAIDYRDRSWTYEELDAAVSRA
                     ASVLLDQGLAPGDRVGAYGHNSDAYLIAFLACSRAGLVHVPVNQNLTGDDLAYIVGQSG
                     SSLVLADPELTDRLPDGVRTLPLRDADDSLLARQATAPAHDGPEPRGEDLVQLLYTSGT
                     TALPKGAMMTHRALVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATN
                     TILDAPDGDQLFDLIEAGRADSLFAPPTVWIALAGRPDFTTRDLDGLRKAYYGASIMPV
                     PVLERLRARWPKLAFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEDG
                     KDVPDGTPGEIVYRSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVK
                     DVINSGGVLVASRQVEDALYTHEGVAEAAVIGLPDERWIEAVTAVVVPRGEVTEAELID
                     HARERLAHFKAPKRVVFVDELPRNASGKILKRELRDRLRDG"
     aSDomain        complement(4567..5739)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS20910_AMP-binding.1"
                     /evalue="3.50E-98"
                     /label="AQI70_RS20910_AMP-binding.1"
                     /locus_tag="AQI70_RS20910"
                     /protein_end="404"
                     /protein_start="13"
                     /score="320.8"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="RRSARRTPARVAIDYRDRSWTYEELDAAVSRAASVLLDQGLAPGD
                     RVGAYGHNSDAYLIAFLACSRAGLVHVPVNQNLTGDDLAYIVGQSGSSLVLADPELTDR
                     LPDGVRTLPLRDADDSLLARQATAPAHDGPEPRGEDLVQLLYTSGTTALPKGAMMTHRA
                     LVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATNTILDAPDGDQLFD
                     LIEAGRADSLFAPPTVWIALAGRPDFTTRDLDGLRKAYYGASIMPVPVLERLRARWPKL
                     AFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEDGKDVPDGTPGEIVY
                     RSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVKDVINS"
     CDS_motif       complement(4660..4749)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS20910_0002"
                     /evalue="9.90E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="AQI70_RS20910"
                     /protein_end="373"
                     /protein_start="343"
                     /score="27.5"
                     /tool="antismash"
                     /translation="PDGTPGEIVYRSPQLCEGYWDKPEETAEAF"
     CDS_motif       complement(5257..5310)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS20910_0001"
                     /evalue="2.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_RS20910"
                     /protein_end="174"
                     /protein_start="156"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LLYTSGTTALPKGAMMTH"
     gene            5899..8337
                     /locus_tag="AQI70_RS20915"
                     /old_locus_tag="AQI70_20910"
     CDS             5899..8337
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003895.1"
                     /locus_tag="AQI70_RS20915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20910"
                     /product="penicillin acylase family protein"
                     /protein_id="WP_062152326.1"
                     /transl_table=11
                     /translation="MRTRPRRLVVAAVALLAATAGLPATAAERQDRQDRQDRQEQLSHG
                     GLSAVIRYTEYGIPHIVAKDYKDLGFGTGWAQAADQVCTLADGFVTVRGERSRFFGPDA
                     ATDFSLSSATRNLSSDLYFRGVRQTRTVERLLAEPAPRGPSRQVEDLMRGFAAGYNAWL
                     KQNRISDPACQGAAWVRPVTPLDVAARFYAIAVLGGQGGAVDDITSARPPTGSAARAKG
                     GGTGPAAEALIRAVRERTDGAAMGSNAVAFHGATTASGRGLLLGNPHYPWHGGRRFWQA
                     QQTIPGELNVAGASLLGSPTVSIGYNAHVAWSHTVSTGVPFNLHQLTLDPADPTVYLVD
                     GKPERMTKRTVTVAVKGGTPVTRTQWWTRYGPVVASADGELPLPWTATTAYALNDPNAG
                     NLRFADTSLGFGKARGTADVLASLARHQGLPWVNTIAADSSGHSLYTQSQVLPRITDDL
                     AARCSTALGRATYPAAGLAVVDGARGDCALGSDADAVQPGVFGPARMPTLKDAPYAENS
                     NDSAWLANADRPLTGYERVFGTIGTQRSLRTRGAIEDVAAMAERGGLTVRDLQRQQFVN
                     RVPAADLAAGDAAEACAALPGGAATGSDGRAVDVSEACPVLAAWDRTMDTGSRGALLYD
                     RFWRKLVTKVPAAQRWKVPFSAADPVRTPHTLNTGAPGFATALADTVAELRAAGIALDS
                     RLGEHQFVERNGQRIPVPGGTEGLGVWNKIEPVWDQARGGYREVSMGSSHIQAVGWDGS
                     RCPVARTLLTYSQSSNPGSPHYRDQTRLFSQEKWVKFRFCEKDILSSPALSVLRVSDKL
                     "
     misc_feature    5962..5964
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8427..8440
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            8542..10017
                     /locus_tag="AQI70_RS20920"
                     /old_locus_tag="AQI70_20915"
     CDS             8542..10017
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982041.1"
                     /locus_tag="AQI70_RS20920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20915"
                     /product="cytochrome P450"
                     /protein_id="WP_079051398.1"
                     /sec_met_domain="p450 (E-value: 6.3e-72, bitscore: 237.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVAPEREHAWRVGTAPGIFPFIGHGIALYRRPLAFLNSLRAHG
                     DLVEIRLGPQRAWMVCHPELVHRVLMDSRTFDKGGPLYDRLRPLLGDGVGTCRHQEHRR
                     QRRLLQPDFRTARVADHTAWMGEEVESVCREWRAGRQVDVSATMLALTTRVVSRVLFCD
                     SLDATTAAEMRGCLATIVRGLFVRTVVPVDALFRVPTPANRRYRRAEDRLHAIVDAAIA
                     ERRGGTSDRTDVLGTLLAATRDQGATAITEQEVHDQLITLLFAGAETTALCLTSALDML
                     ARHPEEERRLHAEVDAVLDAGRLPGPHELPRLVRTRLVLTETLRHRPPGWLFTRVTTKE
                     TELAGHRLPRGATVLYSPYLLHHDPASFPDPDRFRPDRWLPGQAVGVPHKAMIPFAAGS
                     RKCIGDTFAMAEATLALAFVARNWRLRHLPGHVERLRPAATLGPRSLVMVCEPRAPRPT
                     GTPPPADSPKSRAVAAPGVHDPRTAGGDCVDDA"
     gene            10001..11008
                     /locus_tag="AQI70_RS20925"
                     /old_locus_tag="AQI70_20920"
     CDS             10001..11008
                     /EC_number="4.2.3.162"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048704.1"
                     /locus_tag="AQI70_RS20925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20920"
                     /product="(-)-alpha-amorphene synthase"
                     /protein_id="WP_244181759.1"
                     /sec_met_domain="T1TS (E-value: 4.3e-60, bitscore: 199.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTHEEVTLTPQNGIPASNLTQLIDAHLHMPFPFLSNRHASEAA
                     AGVDAWLRACGLTGELGVTAMIAFTRPAELASYNSPTVELDILQIVANQIAYQFIFDDR
                     AEEIGRRSPGGLLPMLSESIAILRDDAPPSTRLGAALADLHRQVRERCTPAQAARWAWK
                     SREYVHGLLYEAVAQAHPRPPRMGLSTSIRSLTAGVEPFYPLAEAAQPCELSAEELHHP
                     VVQRLSRLSADAAVWIPDLFSAVKEQRAGGMINLALAHQRAHRCSLPTAVMLAIRQINS
                     TIREFERLFEEIKPELSPAGIGYVEGMAGWIRGCYYWSRTVPRYADAALTPALV"
     misc_feature    10154..10156
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11321..14230
                     /locus_tag="AQI70_RS20930"
                     /old_locus_tag="AQI70_20925"
     CDS             11321..14230
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048705.1"
                     /locus_tag="AQI70_RS20930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20925"
                     /product="AAA family ATPase"
                     /protein_id="WP_062152327.1"
                     /transl_table=11
                     /translation="MAHGSRQPDTEPRPLLERQRELHALDSALSDLRDAADGLQRARPS
                     GLLAFTGPAGLGKTALLTEARARAAARGFTVLSAWGGEKEQEPAFRLVRQLIQPTLATM
                     DEARRRDFLGSWYDIIAAALGLEATDTARAPDPTGVRDGLDWVMTRLAAMKAPLVLLLD
                     DLHWADLESLGWLASFAPRAAGLPLLLVTAYRPDELPPEAAPFRTVVERHGNRPYPLAR
                     LSAAGVARIVRNELGEGAEDEFCDECWSVTGGSPFETVELAIRLAERNLKGAQHELPAM
                     RDLATAVKGPGLIESLRALGTTTVRFAHAAAVLGPPVSQELAATLAVIGSEDAVQATEK
                     LRAARILADAEGPGGGLEFVHPLIATTIYRSIPSSLRVGLHDRAAEAVRAAGFGPTAAA
                     RHLLEVPCEGRPEVVSCLRDAAREYLRAGAPEAARRVLSRALQEPPLPEDRAALLHELA
                     CSTFLIEPTATVSHLQEALAEPGVDPRLRASIVYRLTQALAHTDRLAEAATVSADEARL
                     ATHPRIRLRMQADHFVWSAFRADEPDSFARSRRLARLAERLTGRHLEERYILGLRAWDA
                     MVRGEPRQTVLGCAEEALRGGLSWTDENRGFEVPVSVALVFMYCDQPRRAEELFTKGMA
                     ECQRMGWRGSHLAQGQTLLGYIRYRRGCLPEAEEFVRAGLRTANRVAGAVPAQWFAIGI
                     LIQTLLARGRTADARHLADSYHYGEVVPNAVIYPDPRTVYAELLLAEGRHDEAERLLSD
                     VGEWLDARGSCNPSWCPWQLHLASAVAPTAPDRALCLARDAVKRARDFGAASMIGQALR
                     VEAEVTGGAAALELHAEAVDHLEQSPASYELARAQVGLGAALSRNGRVQEAADQLYRGL
                     EGAVHCGAEALAARAREELSAAGLRPLPLRYAQADTLSAQERRTAELAVQGQPVAVIAK
                     ELRLTEQGVRQLLSCVYRKVGTDAAGLAKALESFPRPRP"
     gene            complement(14277..15830)
                     /locus_tag="AQI70_RS20935"
                     /old_locus_tag="AQI70_20930"
     CDS             complement(14277..15830)
                     /NRPS_PKS="Domain: AMP-binding (8-412). E-value: 2.7e-76.
                     Score: 248.7. Matches aSDomain:
                     nrpspksdomains_AQI70_RS20935_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138525.1"
                     /locus_tag="AQI70_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20930"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_062152330.1"
                     /sec_met_domain="AMP-binding (E-value: 6.5e-80, bitscore:
                     263.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTPPPGFWAQAAADPDRTVLIAPDGEEWTAGRLHAAANRLVHG
                     LRAAGMERGDAFAVVLPNSAEFFAAYLAASQAGFYLVPINHHFVGPEIAWIVADSGAKV
                     LLAHERFAAPARHAADEAGLPATHRYAIGTVEGFRPYAELLDGQPQSPPASRTLGWVMN
                     YTSGTTGRPRGIRRPLPGKPPEEAYLGGFLGIFGIRPFDDNVHLVCSPLYHTAVLQFAG
                     ASLHIGHRLVLMDKWTPEEMLRLIDREKCTHTHMVPTQFHRLLALPEEVRARYDVSSMR
                     HAIHGAAPCPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISE
                     LAVFDDDGNRLPPGELGTVYLKMNTGGFAYHKDEAKTRKNRIGDFFTVGDLGYLDEDGY
                     LFLRDRKIDMIISGGVNIYPAEIESVLLAHPAVADAAAFGIPHDDWGEEVKAVVEPAPG
                     HEPGPALAAAVLDHCAERLAGYKRPKSVDFITEMPRDPNGKLYKRRLRDPYWEGRARPV
                     "
     aSDomain        complement(14595..15806)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS20935_AMP-binding.1"
                     /evalue="2.70E-76"
                     /label="AQI70_RS20935_AMP-binding.1"
                     /locus_tag="AQI70_RS20935"
                     /protein_end="412"
                     /protein_start="8"
                     /score="248.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FWAQAAADPDRTVLIAPDGEEWTAGRLHAAANRLVHGLRAAGMER
                     GDAFAVVLPNSAEFFAAYLAASQAGFYLVPINHHFVGPEIAWIVADSGAKVLLAHERFA
                     APARHAADEAGLPATHRYAIGTVEGFRPYAELLDGQPQSPPASRTLGWVMNYTSGTTGR
                     PRGIRRPLPGKPPEEAYLGGFLGIFGIRPFDDNVHLVCSPLYHTAVLQFAGASLHIGHR
                     LVLMDKWTPEEMLRLIDREKCTHTHMVPTQFHRLLALPEEVRARYDVSSMRHAIHGAAP
                     CPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDG
                     NRLPPGELGTVYLKMNTGGFAYHKDEAKTRKNRIGDFFTVGDLGYLDEDGYLFLRDRKI
                     DMIIS"
     CDS_motif       complement(15306..15341)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS20935_0001"
                     /evalue="4.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_RS20935"
                     /protein_end="175"
                     /protein_start="163"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YTSGTTGRPRGI"
     gene            complement(15827..16936)
                     /locus_tag="AQI70_RS20940"
                     /old_locus_tag="AQI70_20935"
     CDS             complement(15827..16936)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016703 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of one atom of oxygen (internal
                     monooxygenases or internal mixed function oxidases)
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003890.1"
                     /locus_tag="AQI70_RS20940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20935"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_062152331.1"
                     /transl_table=11
                     /translation="MQTELSKKLGVEHALFGFTPFPAVAAAISRAGGFGVLGAVRYTAP
                     DDLKRDLDWTEAHVDGRPYGLDVVMPAKKVEGVSEADVEAMIPEGHRQFVKDTLAKYGV
                     PELAEGEASGWRITGWMEQVARTQLDVAFDYPIRLLANALGSPPADVVDRAHDRGVLVA
                     ALAGSARHAVKHKERGIDIVVAQGYEAGGHTGEIASMVLTPEVVEAVDPLPVLAAGGIG
                     SGQQVAAALTLGAQGVWLGSIWLTTTEADLHSPALTRKLLAAGSGDTVRSRALTGKPAR
                     QLRTEWTDAWDDANGPGILPMPLQGLLVAEAVSRIQKYEVEPLLGTPVGQIVGRMNSER
                     SVQAVFDDLTRGFERAVDRINRIAGRSGQ"
     gene            17134..18909
                     /locus_tag="AQI70_RS20945"
                     /old_locus_tag="AQI70_20940"
     CDS             17134..18909
                     /EC_number="3.1.1.103"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991791.1"
                     /locus_tag="AQI70_RS20945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20940"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_062152333.1"
                     /transl_table=11
                     /translation="MAAAGARGLTRRQLGRSALALGGAVAVAPFPAGPAEAAPASGRHP
                     TLRHGSAERAGLLSAHLRRLVTDAQAFLGPSPKHPWYAGAVLLAGRGGTVALHRPIGAA
                     VRYQAYDETTDTGVEFPAGQQIAMAEDTVFDLASVSKLFTSILAVQQIERGALALEATV
                     ASYLPDFGRAGKQDITVRQLLTHTSGLRAWIPLYNAPTHEEKLQLIWDEPPLNPPGSKY
                     LYSDLNLISLQLVLEKITGRTLDTLLHDEITAPLGMHRTRFNPPAAWKPRIAATEDARK
                     PWSGLDRGLVWGEVHDENAFSLGGVAGHAGVFSNAWDLAVLGRTLLNGGAYGSSRILQK
                     ESVELMFTDFNTAFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSLVLDPTTDSF
                     LVVLGNSVHPVRSWRSGSAPRVAAADNMARAVPVRPRHGRTAWFSGMASATTASLALPA
                     LDTSCGDARLRCALWWDTEPRSDVLTLEASTDGGTSWQPLAFTTARHGEPPQEHPTGTV
                     TGWSGRVWHRLTAQLPPHRQLVLRWRYATDRLYVGRGAYVDGLRVEASDTVLFDEARPA
                     DAARITASGWTAAAN"
     gene            complement(19029..19220)
                     /locus_tag="AQI70_RS20950"
                     /old_locus_tag="AQI70_20945"
     CDS             complement(19029..19220)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003887.1"
                     /locus_tag="AQI70_RS20950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20945"
                     /product="DUF2795 domain-containing protein"
                     /protein_id="WP_062152335.1"
                     /transl_table=11
                     /translation="MADLSPTDLQKALRGADYPTDKQHLVERARKNKADEKIVSRLDGM
                     KRDRFDGPNDVQKAVFNE"
     gene            complement(19291..20868)
                     /locus_tag="AQI70_RS20955"
                     /old_locus_tag="AQI70_20950"
     CDS             complement(19291..20868)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003886.1"
                     /locus_tag="AQI70_RS20955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_20950"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_208607407.1"
                     /sec_met_domain="DAO (E-value: 3.4e-09, bitscore: 31.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHEGRPGHRTYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLD
                     HTGGAAVSTRPFAGVDARLSRYSYLVSLLPRKIVRDLGLDFRVRTRDVSSYTPVERAGR
                     PTGLLVGGGERRTREAFARLTGGEREYAAWRRFYGMTGEVAQRVFPTLTEPLPSREELR
                     RRVDDEEAWRTLFEEPIGVAIEDRFADDLVRGVVLTDALIGTFTDAHDPSLKQNRCFLY
                     HVIGGGTGAWDVPVGGMGALTDALATAAREAGAIIATGHEAVRIDTDGRTAEITYRTAD
                     GEAVAAARHVLVNASPQELAALTGDAPPPPAEGAQLKVNMLLKRLPRLRDSSVNPREAF
                     SGTFHIAEGYDQLAAAHAQAAAGELPAAPPSEIYCHSLTDPTILGPGLVAQGYHTLTLF
                     GLHTPARLFARDNDAVREELLKSTLAQLDAHLAEPLADCLATDADGRPCIEARSPLDLE
                     RDLRLPGGNIFHRELAWPYAQEGTGRWGVETRQANVLLCGAGAVRGGGVSGVPGHNAAM
                     AVLEAGEE"
     misc_feature    complement(20867..20883)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.21"
                     /tool="antismash"
ORIGIN
        1 cggctgccga gaccgccgag gcgaccaagg ctgccgaccc cgcggagccg tccggtaccg
       61 cgcccggctg gttccgctgg cggcgccgct acccccgtac ggcacacggc gtcaccgtgg
      121 ggacgacggt cctcgccggc gcgctcgtgc tcttcgcgct cctcctgccg aaccgcctcg
      181 aacggatcgg ccccgaggcc ttcttccgcc tccccgccga ggggatcctg ctcgcgggcc
      241 tgctgctggc gctgccaccg cggtcacggc ggctgatggc ggcggtctcc ggtgtgctcc
      301 tcggtctgct caccgtcctg aagttcgtcg acatgggctt ctaccaggtg ctggcccgcc
      361 cgttcgacct ggtgctggac tggatcctgc tcgacgacgc ggcggagttc gtccgggagt
      421 ccttcggacg caccggccag gtgctcgcgg tggtcggggt gatcgtcctg atcgtcgccg
      481 tgctggtcct catgacgctc gcgacagtgc gggtgacgca cctgatggtc cgccaccacg
      541 ccgttgccgc gcgcacgacg ctggtcctcg gcacggcgtg gatcacctgt atgaccctga
      601 gcatccagat caccggcgtc ccgctcgcca ccaagggcaa cgcggagctg ctcaacaacc
      661 gtgtcgagca ggtgcgcgcg gggctccggg acgggcggat cttccagaag caggcggcgg
      721 tggacgcctt cgcgaagacg ccgccggacc agctgctgac ggggctgcgc ggcaaggacg
      781 tgctgttcac gttcatcgag agctacggcc gggtcgccat cgacgacccg gcgatggcgc
      841 cgtatctcga ctcgtccctg aaggagggca ccgacaccct caaggccgcc gggttcgagt
      901 cacgcagcgg gtggctcagg tcgccggtga cgggcgccgg cagctggctc gcccactcga
      961 ccttcctgtc cggactgtgg atcaagaacc agcagcgtta ccggagtctg accaccagcg
     1021 accgggcgac cctcaacagc tacttccgca agaccggcgc atggcgcacg gtcggcatcg
     1081 tgcccggggt gcgccgggcc tggccggagg gcaggtactt cgccctcgac cacatctacg
     1141 actccgagca tctgggctac cacgggccgt acttcagctg gacgcccgtg cccgaccagt
     1201 tcagcctgga ggccttccag cgtctggagc acggcaagaa ggaccgcgag ccgatcatgg
     1261 cggagatcat cctggcctcc agccacaacc cctggtcccc catcgcccgc atgatcgact
     1321 gggacgacct cggcgacggc tcggtcttcc accagatcaa gaaggagggc acggacccca
     1381 aggaggtctg gaaggacgcg gagaaggtcc gcaccgagta ccgccgggcc atcgagtact
     1441 cgctccacag cctcaccgag tgggtcgaac gctacggcac cgatgacacg gtcctcgtct
     1501 tcctcggcga ccaccagccc gtcccgaccg tcaccgccgg cagcacgagc aaggacgtcc
     1561 ccgtcacgat cgtcgcccgc gaccggaagg tcctggaccg aatcgccgac tggggttgga
     1621 cggacggcct gaagcccgcc gagcacgcac cgacctgggg catggacaag ttccgcgacc
     1681 gcttcatgac ggcgtacggg ccccagaggg actgagcgcc atccgggcct cggggatcag
     1741 gccggcggag tggggggcga gagggccggc ccgcgttcac cgcaccgctg ccgggggcac
     1801 tctccgcccg gacaggaaag cgacgagacg tcccacgaac cactccgggt cgtccagcca
     1861 cggatagtgt ccggcgccgg gttgcacggc gacttcggcg tgggggaaga catcggcggt
     1921 gcggtgggcg gtctcggggc gggggcttcc gtcgagttcg ccggccagga cgaggaccgg
     1981 ggcggtgagc cgggagagtg cgtcgcgggt ggcgggcggg tcgtaggcgc cgtcggagcc
     2041 gtagacgtcg ccggcttcgt cgttgaactg gtcgtcgccg cgcgcgtggt gttcccgcgc
     2101 cacgtcgtcc cagcgcccgt agaagaaggg cgcgagcgcg ggctcgaagt cacccctccc
     2161 ctccagccag gcctcgaaca ccgggaacgt ctccgcgaac cacggctcgc cctccctcaa
     2221 ccgggcggcg gccagccggt cctcggcggt gggcggcatc cccagtgccc agggcgtcgc
     2281 ggtcaccagg gccagccgcg ccacccgctg cggataccgg gcggcgtaca gcatggccag
     2341 actcccgccc gccgagtgcg cgagcagatc catatgggcg agccccatgt gggcccgcaa
     2401 catctccacg tcgtccacca ggtggtcgca gcggtacgtc gccgcgtccg ccggcacgac
     2461 cgagtccccg gtgccccgca ggtcgagcag caccagctgc cggtgcgcgg cgagtccgcc
     2521 gagatcaccc agataggcgg aggcctgcat cggcccgccg ggcaggacga cgagcggttc
     2581 gccctccccc cgcaggtggt aggcgatctc ggtcccgtcg gaggcggtga aggtcggcat
     2641 ggccacgatc ttggtcgtcg gccgttctca atgcaacgga gttgcctcac gaggcgacgg
     2701 ggcgacgagg cagtgagcca agaccgcgac ctcgatgcag gcagcagctc aggtcgcaga
     2761 tcctcgggcc ccgttccgcg cggccacgtg cggaaaatgc gggccgcccc cttgcctgat
     2821 cattcgccgc ctggattact gatcacgagc acccggaccg aatgatcggt cgtccggatt
     2881 gacgcggttg gcgagggaga actccccatg acggatgcga cggagctgct ggactcgggg
     2941 gaacggctcg atgcggaggc gctgcgggcg ttgcagctgg agcggctgcg gacatcgctg
     3001 cggcacgcgt acgacaacgt gccgttctac cgcgagtcct tcgacaaggc cggcgtacgg
     3061 cccgacgact gccgttcgct cgccgatctg gcccgcttcc cgttcacgac caaggccgac
     3121 ctgcgcgaga actacccgta cgggatgttc gccgtgcccc aggaccgtat ccgccgcatc
     3181 cacgcgtcca gcggcaccac cgggcggccc acggtcgtcg gctacaccga ggccgacctt
     3241 tccctgtggt ccgacatggt ggcccgttcc atccgggcgg cgggcggtcg gcccggggac
     3301 aaggtgcatg tggcctacgg ctatgggctg ttcacgggcg ggctcggcgc gcactacggg
     3361 gccgaacggc tcggctgtac ggtcatcccc gcgtcgggcg gtatgacggc ccgtcaggtc
     3421 cagctgatcc aggacctgag gcccgagatc atcatggtga ccccgtcgta catgctcacc
     3481 ctcctcgacg agttcgaacg gcggggcgtc gatccgcgcg gcacctcgct gcgcgtgggc
     3541 atcttcggcg ccgagccctg gaccgagcgg atgcgtgcgg agatcgagga gcggttcgcg
     3601 atcgacgccg tcgacatata cgggctgtcc gaggtgatcg ggccgggggt ggctcaggag
     3661 tgcgtggaga ccaaggacgg actgcatgtg tgggaggacc acttcctgcc cgagatcgtc
     3721 gacccgatca gcggtgaggt gctgcccgac ggtgagaagg gcgagctggt gttcacctcg
     3781 ctcaccaagg aggccatgcc ggtcatccgg taccgcacgc gggacttgac gcggctgctg
     3841 ccgggcaccg cccgggtgtt ccggcggatg gagaaggtca ccgggcgcag tgacgacatg
     3901 gtcatcctgc gcggggtcaa tctgttcccc acgcagatcg aggagatcgt gctccggaca
     3961 ccgggtgtgg caccccactt ccagttgcgt ctcagccggg agggccgcct cgacgcgctc
     4021 accgtgcggg cggaagcccg ccccaacgcc gctcccgagt cccgggaggc cgccgcgcgg
     4081 gcgatcgcgg cggcggtgaa ggacggcatc ggggtctcgg tcggcgtcga gatcgtcgac
     4141 cccgagtcgc tggagcggtc cgtgggcaag atccggcgga tcgtggacga acggccggac
     4201 agagcgcgcg gctgagacgg ccgccggcgc gggcggcccc ggtctcccgc gtctcacgga
     4261 ccgccggtgg cgagatcgtc agccgtcccg gagccggtcc cgcagctccc gtttgaggat
     4321 cttcccgctg gcgttgcgcg gaagctcgtc cacgaacacc acccgcttcg gcgccttgaa
     4381 gtgggcgagt ctctcgcggg cgtggtcgat cagttcggcc tcggtcacct cgccgcgcgg
     4441 gacgacgacc gccgtgaccg cctcgatcca ccgctcgtcg ggcagaccga tcacggcggc
     4501 ctcggcgacg ccctcgtgcg tgtacagcgc gtcctcgacc tgccgagaag cgaccagtac
     4561 gccaccggag ttgatgacgt ccttcacccg gtcgacgatc gtgaagtagc cgtgcgcgtc
     4621 ccgcaccgcc aggtcgccgg agcggaacca gccgtcccgg aaggcctcgg cggtctcctc
     4681 gggcttgtcc cagtagccct cgcacaactg cggtgagcgg tagacgatct cgccgggtgt
     4741 gccgtcgggc acgtccttgc cgtcctcgtc gaccacccgg gcgtccacga acaggacggt
     4801 acggccgcag gagtccatcc ggcccttgtg ctcatcgggt gccagcaccg tcgccagcgg
     4861 gccgatctcg ctctggccga agcagttgta gaaggcgagc ttcggccagc gcgcacgcag
     4921 tcgctccagg accggcaccg gcatgatcga ggcgccgtag tacgccttgc gcagtccgtc
     4981 gaggtcgcgg gtggtgaagt cggggcggcc cgcgagggcg atccacaccg tgggcggcgc
     5041 gaagaggctg tccgcgcggc ccgcctcgat caggtcgaag agctggtcgc cgtcgggtgc
     5101 gtcgaggatc gtgttggtgg cgccgacggc gagatacggc agcaggaaca catgcatctg
     5161 ggccgagtgg tacagcggca gtgagtgcac gggacggtcg ccggcgctga ggtccagggc
     5221 ggtgatggcg ctgaggtact cgtgcaccag ggcgcggtgg gtcatcatcg cgcccttcgg
     5281 cagggctgtc gtaccggagg tgtagagcag ctgcaccagg tcctcgccgc gcggctcggg
     5341 gccgtcgtgg gcgggggcgg tggcctgtcg cgcgagcagt gagtcgtcgg cgtcgcgcag
     5401 cggcagcgta cggacaccgt ccgggaggcg gtccgtcagt tccgggtcgg cgaggacgag
     5461 ggagctgccg gactggccga cgatgtacgc gaggtcgtcg ccggtgaggt tctggttgac
     5521 cgggacatgg acgaggcccg cgcgggagca ggcgaggaag gcgatcagat aggcgtccga
     5581 gttgtggccg taggcgccga cccggtcgcc cggtgcgagc ccctggtcga gcaggacgct
     5641 cgccgcgcgc gagacggccg cgtcgagttc ctcgtacgtc caggagcggt cgcggtagtc
     5701 gatcgcgacg cgcgccgggg tgcgccgggc gctgcgtcgc agcaccccgt caaccgtgct
     5761 gccgtgtgca ggcgtcatga cacatgatcc tcggtgcgtc gcacagacag gtcaagcacc
     5821 accgcaggac acccatcagg gatacatacc cgttggtacg ctcaacggct ccttccctca
     5881 atgacgttgg gaggcacgat gcgcacccgc cccagacggc tcgtcgtcgc ggccgtcgcc
     5941 ctgctcgccg ccacggccgg gttacccgcg accgcggccg agcggcagga ccggcaggac
     6001 cggcaggacc ggcaggaaca gctctcgcac ggcggtctgt ccgccgtcat ccgttacacc
     6061 gagtacggca ttccgcacat cgtcgccaag gactacaagg accttggctt cggcaccggt
     6121 tgggcgcagg ccgccgacca ggtgtgcacg ctcgccgacg ggttcgtgac cgtgcgcggc
     6181 gagcgctcgc ggttcttcgg gccggacgcg gcgaccgact tctccctctc ctcggccacc
     6241 aggaacctct ccagcgacct gtacttccgc ggcgtacgtc agacccgcac ggtggaaagg
     6301 ctgctcgccg aaccggcacc gcgcggcccg agccgtcagg tcgaggacct catgcgtggc
     6361 ttcgcggccg gatacaacgc ctggctgaag cagaaccgga tctccgaccc cgcctgccag
     6421 ggggccgcct gggtgcggcc ggtcaccccg ttggacgtgg ccgcccgctt ctacgccatc
     6481 gccgtgctcg gcggccaggg cggcgccgtg gacgacatca cgtccgcccg gccgcccacc
     6541 ggatccgccg cccgcgccaa gggcgggggg accggtccgg ccgccgaggc cctgatccgg
     6601 gccgtgcgcg aacggaccga cggcgccgcc atgggatcga acgcggtcgc cttccacggt
     6661 gccaccacgg cgagcggccg cggtctgctg ctgggcaatc cgcactatcc gtggcacggc
     6721 ggacgccgtt tctggcaggc gcagcagacg attcccggcg agctgaacgt ggcaggcgcc
     6781 tcgctgctcg gctcgccgac ggtctccatc ggttacaacg cccatgtggc gtggagccac
     6841 accgtctcga ccggcgtccc gttcaatctg caccagctga cgctggatcc ggccgacccc
     6901 accgtctacc tcgtggacgg caagcccgag cggatgacga agcgcaccgt gaccgtcgcg
     6961 gtcaagggtg gcacgccggt gacccgcacc cagtggtgga cccggtacgg cccggtcgtc
     7021 gcctcggccg acggcgagct cccgctgccg tggaccgcca cgacggcgta cgcgctgaac
     7081 gaccccaacg cggggaacct gcggttcgcc gacacctcgc tgggcttcgg caaggcgcgc
     7141 ggcacggccg acgtcctcgc ctccctcgcg cggcaccagg gcctgccgtg ggtgaacacc
     7201 atcgccgcgg actcctccgg gcactccctc tacacccagt cgcaggtgct gccccggatc
     7261 accgacgacc tggcggcgcg gtgttccacg gccctcggca gggccaccta tccggcggcc
     7321 ggcctcgcgg tggtcgacgg cgcccgcggc gactgcgcgc tcggcagcga cgccgacgcg
     7381 gtccagcccg gtgtcttcgg gccggcccgg atgccgacac tgaaggacgc gccgtacgcg
     7441 gagaactcca acgacagcgc gtggctggcc aacgccgacc ggccgctcac cggatacgag
     7501 cgggtcttcg ggaccatcgg tacgcagcgc tcactgcgca cccgtggcgc gatcgaggac
     7561 gtggcggcga tggccgagcg gggcggtctg accgtccgcg atctgcagcg gcagcagttc
     7621 gtgaaccggg tgccggcggc cgacctggcc gcgggcgacg cggccgaggc gtgtgccgcg
     7681 ctgcccggcg gtgcggcgac cggcagcgac ggcagggccg ttgacgtgtc cgaggcctgc
     7741 ccggtgctcg ccgcctggga ccgcaccatg gacaccggca gccgcggggc cctgctctac
     7801 gaccggttct ggcgcaagct ggtgacgaag gtgccggccg cccagcggtg gaaggtgccg
     7861 ttctcggcgg cggaccccgt ccgcaccccg cacaccctca acaccggcgc cccgggcttc
     7921 gccacggccc tcgcggacac ggtcgcggag ctgagggcgg cgggcatcgc gctcgactcc
     7981 cgcctcggtg agcaccagtt cgtcgaacgg aacggtcagc gcatccccgt tccgggcggc
     8041 accgaggggc tgggcgtgtg gaacaagatc gagcccgtgt gggaccaggc gcgcggcggc
     8101 taccgggagg tgtcgatggg ctccagtcat atccaggcgg tgggctggga cggcagccgc
     8161 tgtccggttg cccgtactct gctgacatac tcgcagtcct cgaatcccgg ctcgccgcat
     8221 taccgcgacc agacgcggct gttctcccag gagaagtggg tgaagttccg cttctgtgag
     8281 aaggacatcc tgtcgtcgcc cgcgctgagc gtgctccggg tgagcgacaa gctttgacga
     8341 cgagtggtcc cgcggtgacg cgggaccact ttccgatcgc cgcgaattca gccctgtgcc
     8401 tctctgtgct cccgtgcgcc cccctgcaga aaggatccaa ggcaacaaac accggttcgg
     8461 attgggcagg acattactca gggaccaagt caatgtaatg cccatcgatt tcgcgtgtcg
     8521 aatgaggcag gggggtattc gatgaaccgt gtcgcgcctg aacgagaaca cgcatggcgg
     8581 gtgggtactg cgccgggcat attcccgttc atcggccacg gtatcgcttt gtaccgtcgc
     8641 ccgctggctt ttctgaattc attgcgcgct cacggggacc tggtcgagat acggctgggt
     8701 ccgcagcgcg cctggatggt gtgtcacccg gagttggtcc accgggtgct catggactca
     8761 cgcacgttcg acaagggagg cccgctctac gacaggctgc ggccgctgct gggtgacggg
     8821 gtcggcacct gccgccatca ggagcaccgg cgccagcgca ggctgctcca gccggacttc
     8881 cgtacggccc gcgtcgccga ccacacggct tggatgggcg aggaagtgga gtcggtgtgc
     8941 cgtgagtggc gggccggccg gcaggtcgac gtcagcgcga ccatgctggc actgacgacg
     9001 cgggtggtca gccgtgtcct gttctgcgac tcgctcgacg ccacgacggc cgccgagatg
     9061 cgcggctgcc tcgccaccat cgtccgcggc ctgttcgtcc ggacggtggt gccggtcgac
     9121 gccctcttcc gcgttcccac gcccgcgaac cgtcgttacc ggcgtgcgga agaccgcctg
     9181 cacgcgatcg tcgacgcggc catcgccgaa cgccgagggg gcacttcgga ccggaccgac
     9241 gtgctgggga ctctgctggc ggccacgcgg gaccagggcg caacggcgat caccgaacag
     9301 gaggtccacg accagctcat cacactcctg ttcgcggggg ccgagaccac cgccctgtgt
     9361 ctcacctccg ccctggacat gctggcgcgg catccggagg aggagcgccg gctgcacgcc
     9421 gaggtcgacg ccgtgctcga cgcgggccgg ctgcccggtc cccacgagct gccgcgcctg
     9481 gtccgcaccc ggctcgtcct caccgagaca cttcgccacc gtccgccggg ctggctcttc
     9541 acccgcgtca ccaccaagga aacggagctg gccggccacc gtctccctcg gggcgccacc
     9601 gtcctgtaca gcccgtacct cctgcaccac gaccccgcct cgttccccga ccccgaccgc
     9661 ttccgccccg accgctggct gccggggcag gccgtcggcg tcccgcacaa agcgatgatt
     9721 ccgttcgccg cgggcagccg taagtgcatc ggcgacactt tcgccatggc ggaggcaacc
     9781 ctggcgctgg cgttcgtcgc gcggaactgg cggctgcgcc acctgcccgg acacgtggag
     9841 cggctgcgtc ccgcggcgac cctggggccg aggtcactgg tgatggtctg cgaaccacgg
     9901 gcaccccgac cgaccggcac accgcctccg gcggactccc ccaaatcccg ggcagttgcg
     9961 gcgcccggcg tacacgaccc ccgaacggca ggtggcgact gtgtcgacga cgcatgagga
    10021 agtcacgctc accccgcaga acggaattcc ggcctccaac ctgacgcaac tgatcgacgc
    10081 ccatctccat atgccgttcc cgttcctgag caatcgccac gcgtccgaag cggccgccgg
    10141 cgtcgacgca tggttacgcg catgcgggct gaccggcgaa ctgggggtga cggcgatgat
    10201 cgccttcact cggccggccg aactcgcgtc ctacaacagt ccgacggtgg agttggacat
    10261 cctccagatc gtggccaacc aaatcgccta tcaattcatc ttcgacgacc gggcggaaga
    10321 gatcggccgg cggtcaccgg gcggcctgct gcccatgctg agcgagagca tcgcaatcct
    10381 gcgcgacgac gccccgccca gcacgcgcct cggggcggcg ctggccgacc tccaccggca
    10441 ggtccgagaa cggtgcaccc ccgcgcaggc cgcgcgctgg gcctggaaga gccgcgaata
    10501 cgtgcacggc ctcctgtacg aggcggtggc ccaggcccat ccccgccccc cacgcatggg
    10561 actgagcacc tcgatacgtt ccctcaccgc gggcgtcgag cccttctacc cgttggccga
    10621 agcggcgcaa ccgtgcgagc tgtccgccga ggagctccat caccccgtcg tacaacgcct
    10681 gagccggctg tccgccgacg cggccgtgtg gatacccgac ctcttctccg cggtgaagga
    10741 gcagcgggcg ggcggaatga tcaatctggc cctcgcccac cagcgggcgc accggtgctc
    10801 cctgccgacg gccgtcatgc tggccatccg gcagatcaac agcacgatca gggagttcga
    10861 gcggctcttc gaggagatca aacccgagtt gagccctgcc gggatcggct acgtggaagg
    10921 catggccggc tggatccgcg ggtgttacta ctggtcccgc accgtgccgc gctacgccga
    10981 cgcggcgctg acgcccgccc tcgtgtgagg cctcgtgcgc ccgccgaagc cgcgcggcgg
    11041 gcgcacgggg ccaagcacag ccacagccac agccacagcc acagccacag ccacagccac
    11101 agccacagcc acagccacga ccgattgtcc tcgacggccg cgcctccgaa aggcactcat
    11161 tcggacctga ctacccgaac ggcggagaac acaaccactt ccgcacagga tttcacccgt
    11221 atctgtcatc cccgtacccg aatgcaccca ccgggcgctc accatgggcg tacgctctgc
    11281 gctgtcctcc gaggatcaac gacaggaagc ggtagggcac atggcgcatg ggtcgcggca
    11341 accggacacc gagccccgcc cgttgctgga acgccagcgg gaactccatg cgctcgactc
    11401 cgccttgtcg gacctgcgcg acgccgccga cggcctgcag cgggcacggc ccagcggact
    11461 gctcgccttc accggcccgg ccgggctggg caagacggcg ctgctcaccg aggcacgcgc
    11521 ccgcgccgcg gcccgtgggt tcacggtgct ctcggcatgg ggtggcgaga aggaacagga
    11581 gccggcgttc cggctggtgc gccagctcat ccagcccacc ctggccacga tggacgaggc
    11641 ccgacggcgg gacttcctgg gaagttggta cgacatcatc gccgccgcgc tcggcctgga
    11701 ggcgacggac accgcccgcg cgccggaccc gaccggggtg cgcgacggcc tcgactgggt
    11761 catgacgcgt ctcgcggcga tgaaggcgcc cctcgtcctg ctcctggacg acctgcactg
    11821 ggccgatctc gagtcgctcg gctggctggc ctcgttcgct ccgcgggccg ccggtctgcc
    11881 gctcctgctc gtcaccgcct accggcccga cgaactgccg cccgaggcgg cgcccttccg
    11941 cacggtcgtc gaacgtcacg ggaaccgccc gtacccgctg gcgcggctca gcgccgccgg
    12001 cgtggcccgg atcgtacgga acgaactggg cgagggagcc gaggacgagt tctgcgacga
    12061 gtgctggtcg gtcaccggcg ggagcccgtt cgagaccgtg gaactcgcca tcaggctcgc
    12121 ggagcggaat ctgaagggcg ctcagcacga gttgcccgcg atgcgggacc tggccaccgc
    12181 ggtcaagggc cctggactga tcgagagcct gcgcgcgctc ggcacgacca cggtccggtt
    12241 cgcccatgcc gcagccgtgc tgggtccgcc ggtgtcgcag gaactcgccg ccacgctcgc
    12301 ggtgatcggc agcgaggacg ccgtacaggc gaccgagaag ctgcgcgccg cgcggatcct
    12361 ggccgacgcg gaagggcccg ggggcggtct cgagttcgtc cacccgctga tcgccacgac
    12421 gatctaccgg tccatcccct caagtctgcg ggtcggcctg cacgaccggg ccgcggaggc
    12481 cgtccgcgcg gcggggttcg ggccgaccgc ggccgcccgg catctgctgg aggtcccctg
    12541 cgaaggcagg cccgaggtgg tctcgtgcct gcgggacgcc gcccgcgagt accttcgggc
    12601 cggggctccg gaggctgccc ggcgtgtcct gtcccgagcg ctgcaggagc caccgcttcc
    12661 ggaggaccgg gccgccctgc tgcatgagct cgcgtgctcg accttcctga tcgagcccac
    12721 ggccacggtc agccatctcc aggaggcgct ggcggagccc ggggtggatc cccggctgcg
    12781 ggcctccatc gtctaccggc tcacccaggc gctggcccac acggaccggc tggccgaggc
    12841 ggcgaccgtg tccgccgacg aggcccggct cgccacgcat ccacggatcc ggctgcgcat
    12901 gcaggccgat cacttcgtct ggagcgcctt ccgcgccgac gagcccgact cgttcgcccg
    12961 ctcgcgccgg ctggcacggc tggccgagcg actgaccggc cgccatctgg aggagcggta
    13021 catcctgggg ctgcgggcgt gggacgccat ggtgcgcggc gagccccgcc agacggtcct
    13081 cggatgcgcc gaggaggccc tgcgcggcgg tctgagctgg acggacgaga accggggctt
    13141 cgaggtgccc gtatcggtcg ccctggtgtt catgtactgc gaccagccgc ggcgggccga
    13201 agagctgttc accaagggca tggccgagtg ccagcggatg ggctggcgcg gctcccacct
    13261 ggcgcagggg cagactctcc tcggctacat ccgctaccgc cgcggctgcc tccccgaggc
    13321 ggaggagttc gtgcgggccg ggctgcgcac cgccaaccgt gtggcggggg ccgtacccgc
    13381 gcagtggttc gccatcggca tcctcatcca gaccctgctc gcccggggcc gcaccgccga
    13441 cgcgcgtcac ctcgccgact cctatcacta cggcgaggtc gtcccgaacg ccgtcatcta
    13501 ccccgatccc cgcacggtgt acgccgaact gctcctggcc gagggccggc atgacgaagc
    13561 ggagcgcctt ctgtccgacg tcggggaatg gctggacgca cggggctcgt gcaacccctc
    13621 ttggtgcccc tggcagctgc atctggcgtc cgccgtcgcg cccaccgccc ccgaccgtgc
    13681 gctctgcctc gcccgggacg ccgtcaagcg ggcccgggac ttcggtgccg cgtcgatgat
    13741 cgggcaggcg ctccgcgtcg aggccgaggt gaccggcgga gcggcggcgc tcgaactgca
    13801 cgcggaggcc gtggaccacc tggaacagtc acccgcctcc tacgagctcg cccgtgccca
    13861 ggtcggcctc ggcgccgccc tgtcccgcaa cggccgggtg caggaggccg ccgatcagct
    13921 ctaccgaggc ctggaaggtg ccgtccactg cggggccgag gcgctcgccg cccgggccag
    13981 ggaagagctg tcggcggccg ggctgcgccc gctgccgctg cgctatgcgc aggcggacac
    14041 cctgtccgcg caggaacgcc gtaccgccga actggccgtc cagggccaac cggtggcagt
    14101 gatcgccaag gaactgcgtc tcaccgagca gggcgtgcgg cagttgctgt cctgcgtcta
    14161 ccgcaaggtc ggcaccgacg ccgccggtct cgccaaggcc ctggagagct tccctcgccc
    14221 tcgcccctga ggcctcccgt ccggccgccg gactcggtgt ccgtgccggg cctcggtcac
    14281 acgggccgcg cgcgtccctc ccagtacggg tcccgcaacc gccgtttgta cagcttgccg
    14341 ttggggtcgc gcggcatctc ggtgatgaag tcgacgctct tgggccgttt gtagccggcg
    14401 agccgctcgg cgcagtggtc gaggacggcg gcggcgaggg cggggcccgg ttcgtggccg
    14461 ggggccggtt cgaccaccgc cttgacctcc tcgccccagt cgtcgtgcgg gatgccgaag
    14521 gcggcggcgt cggcgacggc cgggtgggcg aggaggacgg attcgatctc ggccgggtag
    14581 atgttgacgc caccggagat gatcatgtcg atcttgcggt cgcggaggaa gaggtagccg
    14641 tcctcgtcga ggtagccgag gtcgccgacg gtgaagaagt cgccgatgcg gttcttccgc
    14701 gtcttggcct cgtccttgtg gtaggcgaag ccgccggtgt tcatcttcag gtagacggtg
    14761 ccgagttcgc cgggcgggag ccggttgccg tcgtcgtcga agacggcgag ttcgctgatg
    14821 ggccaggcct tgccgacggt gccgggcttc ttcagccagt cctccgcggt ggcgaaggcg
    14881 ccgccgccct cgctggccgc gtagtactcc tccacgcacg gcccccacca gtcgagcatg
    14941 gcccgcttca cgtggtcggg gcagggggcg gcgccgtgga tggcgtgccg catggaggag
    15001 acgtcgtagc gggcccgtac ctcctcgggc agggcgagca ggcggtggaa ctgggtcggg
    15061 accatgtggg tgtgagtgca cttctcccgg tcgatcagcc ggagcatctc ctcgggcgtc
    15121 cacttgtcca tcaggacgag gcggtggccg atgtgcaggg acgcgcccgc gaactggagg
    15181 acggccgtgt ggtagagcgg cgagcagacc aggtgcacgt tgtcgtcgaa cgggcggatg
    15241 ccgaagatgc cgaggaatcc gccgaggtac gcctcctcgg gcggcttgcc gggcagaggg
    15301 cgccggatgc cgcgggggcg gccggtggtg ccggaggtgt agttcatgac ccagccgagg
    15361 gtgcgggatg cgggcggcga ctgcggttgc ccgtcgagga gttcggcgta cggccggaag
    15421 ccctcgaccg tgccgatcgc gtaccggtgg gtggcgggca ggccggcctc gtcggcggcg
    15481 tggcgggcgg gggcggcgaa gcgttcgtgg gcgaggagca ccttggcgcc ggagtcggcg
    15541 acgatccagg cgatctcggg gccgacgaag tggtggttga tcgggaccag gtagaacccg
    15601 gcctggctgg cggcgaggta cgcggcgaag aactcggcac tgttgggcag gacgaccgcg
    15661 aaggcgtcgc cgcgttccat tccggcggcg cgcaggccgt ggacgaggcg gttggcggcg
    15721 gcgtgcagcc ggccggcggt ccattcctcg ccgtcggggg cgatgaggac cgtgcggtcg
    15781 ggatcggccg cggcctgggc ccagaagccc gggggaggtg tgctcgtcac tggccgctcc
    15841 ttccggcgat gcggttgatg cgatcgacgg ctcgctcgaa gccgcgggtg aggtcgtcga
    15901 agacggcctg gacgctgcgt tcgctgttca tccggccgac gatctggccg acgggggtgc
    15961 cgagcagcgg ctcgacctcg tacttctgga tgcgggagac ggcttcggcg accagcaggc
    16021 cctgcagggg catgggcagg atgccgggcc cgttcgcgtc gtcccaggcg tcggtccact
    16081 cggtgcgcag ctgacgtgcg ggcttgccgg tgagggcgcg ggagcgcacg gtgtcgccgg
    16141 agccggcggc gagcagtttg cgggtcaggg cgggtgagtg cagatcggcc tctgtggtgg
    16201 tcagccatat ggagcccagc cacacacctt gggcgccgag ggtgagtgcg gcggccacct
    16261 gttggccgct cccgatgccg ccggccgcca gcacgggcag cgggtcgacc gcctccacga
    16321 cctcgggggt gagcaccatg gaggcgatct caccggtgtg gccgccggcc tcgtagccct
    16381 gggccaccac gatgtcgatg ccgcgttcct tgtgcttgac ggcgtgccgg gcgcttccgg
    16441 cgagcgcggc gacgagcacg ccccggtcat gggcgcggtc caccacgtcg gcgggcggtg
    16501 agcccagggc gttggccagc agcctgatcg gatagtcgaa ggctacgtcc agctgggtgc
    16561 gggcgacctg ctccatccat ccggtgatgc gccagccgga cgcctccccc tcggcgagtt
    16621 cgggcacgcc gtacttggcg agggtgtcct tgacgaactg ccggtgccct tcggggatca
    16681 tcgcctcgac gtcggcctcg ctgacgcctt ccaccttctt ggcgggcatg acgacgtcca
    16741 gtccgtaggg ccgcccgtcg acatgggcct cggtccagtc aaggtcgcgt ttgaggtcgt
    16801 cgggggccgt gtagcggacc gcgccgagca ctccgaagcc gccggcccgg ctgatggcag
    16861 cggcgacggc ggggaacggc gtgaagccga aaagggcgtg ctcgactccc agtttcttgc
    16921 tcagctccgt ctgcatgggc gcaggatgcc gcagtcccct ggacgacgga agaccaattc
    16981 tgatgctgcg tcagatttct ggacgccccg cagcaccctc gcgagaacct ccgggggtcg
    17041 cccgccccat tgacacatcc cgcacctgac gggaaagttt caccgcgcaa ggagatcccg
    17101 gaaagatact ttcagatcac gggaggtccc tggatggccg ctgcaggtgc gagaggactg
    17161 acccgccgcc aactgggccg cagcgcactg gccttgggcg gtgccgtggc cgtcgcgccc
    17221 ttccccgccg gtccggccga ggccgcgccc gcatccggcc gtcaccccac cctgcgccac
    17281 ggctccgccg agcgcgccgg cctcctctcc gcccacctcc gccgactcgt caccgacgcg
    17341 caggcgttcc tcggcccctc ccccaagcac ccctggtacg cgggcgccgt actgctcgcc
    17401 gggcgcggcg gcaccgtggc cctgcaccgg cccatcgggg cggcggtgcg ctaccaggcg
    17461 tacgacgaga cgaccgacac cggcgtggag ttcccggccg gtcagcagat cgcgatggcc
    17521 gaggacaccg tcttcgatct ggcctcggtg tccaagctgt tcacctcgat cctcgccgtg
    17581 cagcagatcg agcggggcgc gctggcgctg gaggcgacgg tcgcctccta cctgccggac
    17641 ttcggccgtg cgggcaagca ggacatcacc gtccgtcagc tcctcaccca cacctcggga
    17701 ctgcgcgcct ggatcccgct gtacaacgca ccgacccacg aggagaagct ccagctcatc
    17761 tgggacgagc cgccgctgaa cccgccgggc agcaagtacc tctactccga cctgaacctg
    17821 atctccctcc aactggtcct ggagaagatc accggccgta cgctggacac cctcctgcac
    17881 gacgagatca ccgctccgct cggcatgcac cgcacccggt tcaacccgcc cgccgcctgg
    17941 aaaccgagga tcgcggccac cgaggacgcc cgcaaaccct ggtccgggct ggaccgcggg
    18001 ctcgtgtggg gcgaggtgca cgacgagaac gccttcagcc tcggcggagt cgccggccac
    18061 gcgggcgtgt tctcgaacgc ctgggacctc gcggtcctcg gccggaccct gctcaacggc
    18121 ggcgcctacg gcagctcccg cattcttcag aaggagtcgg tggagctgat gttcaccgac
    18181 ttcaacaccg cgttcccggg ggacgagcac ggcctcggct tcgagctcta ccagcactgg
    18241 tacatgggag cgatggccac cccgcgcacc gcgggccaca ccggcttcac cggcacctcg
    18301 ctggtcctcg acccgacgac cgactccttc ctcgtcgtgc tcggcaactc cgtccatccg
    18361 gtacgcagtt ggcgctccgg ctccgcgccc cgggtggccg ccgccgacaa catggcgcgg
    18421 gccgttcccg tccgcccacg gcacggtcgt accgcatggt tctccggaat ggcgagcgcc
    18481 acgaccgcaa gcctcgcgct ccccgcgctc gacacgtcct gcggcgacgc acgactgcgg
    18541 tgcgccctgt ggtgggacac agagccccgg tcggacgtcc tcaccctgga ggcgtcgacc
    18601 gacgggggca ccagctggca gccgctcgcc ttcacgacgg cgcgccacgg cgagccgccg
    18661 caggagcatc cgacgggcac ggtcaccggc tggtcgggcc gcgtctggca ccggctcacg
    18721 gcacaactcc cgccgcaccg gcagctggtg ctccgctggc ggtacgcgac cgaccggctg
    18781 tacgtgggcc gcggcgcgta cgtcgacggg ctgcgcgtcg aggcgtcgga caccgtcctc
    18841 ttcgacgagg cccgcccggc ggacgcggcg cggatcacgg cgagcggctg gaccgccgcc
    18901 gcgaactgac cggctccgcg agccgaccgg ctcggcgcgg cacgtgcacc ggcccgttcg
    18961 ggcgggtcac cggacccgct catccgtcgg ggccggactc ctggagagcc cggccccggc
    19021 gttgctcgct actcgttgaa gacggccttc tggacgtcgt tcggcccgtc gaagcggtcg
    19081 cgcttcatgc cgtcgaggcg gctgacgatc ttctcgtcgg ccttgttctt gcgggcgcgc
    19141 tccaccaggt gctgcttgtc ggtcgggtag tcggcaccgc ggagggcttt ctgcaggtca
    19201 gtggggctga gatcggccat ggcagcctcc ccgtgagtcg tacgaattgt ccgttctgcc
    19261 cagtacccct cctcgccgga ggcatgtgcg tcattcctcg ccggcctcca ggacggccat
    19321 cgccgcgttg tgccccggca ccccgctcac ccctcccccg cgcaccgcgc ccgccccgca
    19381 cagcagcaca ttcgcctgcc gggtctccac gccccagcgc ccggtgccct cctgggcgta
    19441 cggccaggcc agctcgcggt ggaagatgtt gccgccgggc aggcgcaggt cgcgctccag
    19501 gtccagcggg ctcctggcct cgatacaggg gcgcccgtcg gcgtcggtcg ccaggcagtc
    19561 ggcgagcggc tcggcgaggt gggcgtccag ctgggcgagc gtcgacttca gcagttcctc
    19621 gcgtacggcg tcgttgtccc gtgcgaagag ccgggccggg gtgtgcaggc cgaagagggt
    19681 gagcgtgtgg tagccctggg cgacgaggcc gggtccgagg atggtcgggt ccgtcagcga
    19741 gtggcagtag atctcggacg gcggcgcggc ggggagttcc ccggcggcgg cctgggcgtg
    19801 ggcggcggcc agttggtcgt agccctcggc gatgtggaag gtgccggaga acgcctcgcg
    19861 ggggttcacg gagctgtcgc gcagccgggg caggcgcttg agcagcatgt tcaccttgag
    19921 ctgggcgccc tcggcggggg gcgggggcgc gtcgccggtg agggcggcca gttcctgcgg
    19981 ggaggcgttc accaggacgt gccgggccgc ggcgacggcc tcgccgtccg cggtccggta
    20041 ggtgatctcc gcggtacggc cgtccgtgtc gatccgtacc gcctcgtgac cggtggcgat
    20101 gatcgcgccc gcctcgcgcg ccgccgtggc cagggcgtcg gtgagggcgc ccatgccgcc
    20161 gacgggcacg tcccaggcgc cggtgccgcc gccgatcacg tggtagagga agcagcggtt
    20221 ctgcttcagt gacggatcgt gggcgtcggt gaaggtgccg atgagcgcgt cggtgaggac
    20281 caccccccgg accaggtcgt cggcgaaccg gtcctcgatc gcgacaccga tcggttcctc
    20341 gaagagggtc cgccaggcct cctcgtcgtc cacccggcgg cgcagctcct cccggctcgg
    20401 cagcggttcg gtgagggtcg ggaacacccg ctgggcgacc tcgccggtca tgccgtagaa
    20461 gcgccgccag gccgcgtact cgcgctcgcc gccggtcagc cgggcgaacg cctccctggt
    20521 gcgccgctcc ccgccgccga ccagcagtcc ggtcggccgt ccggcccgtt ccacgggcgt
    20581 gtacgaggag acgtcgcggg tgcggacccg gaagtccagg ccgaggtcgc gcacgatctt
    20641 cctgggcagc aggctgacca ggtacgagta gcgcgacagc cgcgcgtcca caccggcgaa
    20701 cgggcgcgtg gagacggcgg cgcccccggt gtggtccagc cgctccagca ccagcacgga
    20761 cctgccggcc cgggccaggt aggcggcggc gaccaggccg ttgtgccctc cgccgacgat
    20821 gacggcgtcg tacgtacggt gtccggggcg tccctcgtgt gcaggcatgg ttcttcgtaa
    20881 cacgtgatga tctaggtcgg ccataggtgc gggcgtccgg agtcacgagc ctccggtcgc
    20941 ccgctgctgc cgcagcaccg ccaccctccg gtacagctcg accgcctccg cgccccgccc
    21001 gagctgct
//
