LOCUS       NZ_KQ947987            27890 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s004, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ947987
VERSION     NZ_KQ947987.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 770615)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 770615)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 227603
            Orig. end                         :: 255493
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ947987.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27890
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="3"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..27890
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27890
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17890](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17890)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(1468..1482)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.14"
                     /tool="antismash"
     misc_feature    complement(1715..1726)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    2103..2117
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    2721..2736
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     misc_feature    complement(2848..2858)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2911..3300
                     /locus_tag="AQI70_RS14530"
                     /old_locus_tag="AQI70_14520"
     CDS             2911..3300
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497048.1"
                     /locus_tag="AQI70_RS14530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14520"
                     /product="cell division protein SepF"
                     /protein_id="WP_003997118.1"
                     /transl_table=11
                     /translation="MNSHDVTDEQWEGLAQVVPLRGRDAWPSAVDHRVAPEAETEPRRR
                     FVVLRVNVFADAREVAETLMAGIPVLLDLTGAETEVAKRVLDFSTGVVFGLASGMHRVD
                     RNVFLLTPPGTEVSGLMEGAGVPGT"
     misc_feature    complement(3351..3365)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            3392..4576
                     /locus_tag="AQI70_RS14535"
                     /old_locus_tag="AQI70_14525"
     CDS             3392..4576
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997117.1"
                     /locus_tag="AQI70_RS14535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14525"
                     /product="ATP-binding protein"
                     /protein_id="WP_208607363.1"
                     /transl_table=11
                     /translation="MAVPSSSAAASVPSVAPSGGVGTHPDRPRVTELRLSAFAGHRRAG
                     FPLGTLTLLAGPSGCGKTSALRAYEALARLGGGDAVGAVFPDPGACVPERARPDAQRRR
                     GFRIGCTADGPEGPVRLDVAVQAEPELRIVGERLSAGGVVLLETALRDPSRPWVQAAWH
                     TAGQSPVTRGPLPDDRLGTALLPLRVAGRTAGQRRVLAAAEQMVVALRSVFACDPRPGR
                     MRAPVPTGSGRLLGGCDNLADVLWRTRAECGRRHQQFVAAVRAGCAGAVADVLAEALPG
                     GVVRGVVERGDGFRTELGRLGDGELRYLALCLVLLTGPGVLEVDPAGEVPAAMQTLTVL
                     ADGFDRGLDPGQRGELVRLAARMCGRGHIRVVGAVSDASWVEGVDGVTVVDLSP"
     gene            4573..4917
                     /locus_tag="AQI70_RS14540"
                     /old_locus_tag="AQI70_14530"
     CDS             4573..4917
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322718.1"
                     /locus_tag="AQI70_RS14540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14530"
                     /product="nucleotide pyrophosphohydrolase"
                     /protein_id="WP_062148853.1"
                     /transl_table=11
                     /translation="MTGEPGESRPLDLAALQRRLAEFAAARDWQPYHTPKNLVAALSVE
                     ASELVEIFQWLTPEESARVMDDAETAGRVTDEVADVLAYLLQLCEVLGIDPLAALDAKI
                     DRNERRFPAP"
     gene            5139..5609
                     /locus_tag="AQI70_RS14545"
                     /old_locus_tag="AQI70_14535"
     CDS             5139..5609
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030573.1"
                     /locus_tag="AQI70_RS14545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14535"
                     /product="DUF6099 family protein"
                     /protein_id="WP_062148856.1"
                     /transl_table=11
                     /translation="MDAVRLIGTSRRALAGSRRVPEIMTEVWQAQALAQAIGSRLAVFG
                     PPELRGEALGLTELAGRGCGVLDTPELADGDLRAAQLTELGDARQALMSLGSLLGEVGI
                     ALVGMASASDDEGTYWQCMEAIDAADESRDRVLEMLRRLADREQVLPEREAG"
     gene            complement(5946..6146)
                     /locus_tag="AQI70_RS14550"
                     /old_locus_tag="AQI70_14540"
     CDS             complement(5946..6146)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997113.1"
                     /locus_tag="AQI70_RS14550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14540"
                     /product="hypothetical protein"
                     /protein_id="WP_062148859.1"
                     /transl_table=11
                     /translation="MSEELTPQQAGGPGPQKGLLQQMEELMAALNADLSALDADLQSTG
                     GAGRPAPTGPGHQAPRGDGVG"
     gene            6386..7309
                     /locus_tag="AQI70_RS14555"
                     /old_locus_tag="AQI70_14545"
     CDS             6386..7309
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033810.1"
                     /locus_tag="AQI70_RS14555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14545"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_062148861.1"
                     /transl_table=11
                     /translation="MDLRIFTEPQQGATYETLLSVAKATEDLGFDAFFRSDHYVKMGSG
                     DGLPGPTDAWITLAGLARETKRIRLGTLMTAGTFRLPGVLAIQVAQVDQMSGGRVELGL
                     GAGWFEEEHKAYGIPFPKEKFGRLEEQLAIVTGLWATEVGDTFDFHGTYYDLTDSPALP
                     KPAQDRIPVLIGGHGATRTPRLAGRYADEFNMPFASVEDSERQFGRVRVAAEEAGRKGD
                     DLVYSNALVVCVGKDDQEVARRAAAIGRQVDELKLNGLAGSPDEVVDKIGRYQEIGSAR
                     IYLQVLDLDDLDHLELISSQVQSQLS"
     misc_feature    7316..7336
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.39"
                     /tool="antismash"
     gene            7485..7901
                     /locus_tag="AQI70_RS14560"
                     /old_locus_tag="AQI70_14550"
     CDS             7485..7901
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997112.1"
                     /locus_tag="AQI70_RS14560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14550"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_062148863.1"
                     /transl_table=11
                     /translation="MLLNLEQQTEGRGVGAVRLGVPVHSRRCVLRQQIGAFIEHRLGDP
                     ELTPAAIAEAHHISVRYLYQVFDTHQMTVAAWIRHCRLEHCHRDLADPRLRTRSIRAIA
                     SRWGFSDAAHFSRAFRAAYGMSPSDHRQLALGHG"
     gene            complement(7941..9170)
                     /locus_tag="AQI70_RS14565"
                     /old_locus_tag="AQI70_14555"
     CDS             complement(7941..9170)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963620.1"
                     /locus_tag="AQI70_RS14565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14555"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_062148866.1"
                     /transl_table=11
                     /translation="MGTGKGGFSAAGLRRVRDVLARHVESGRIPGLVALVDRGGETHVE
                     ALGTMRHDGGAPMRRDTIFRMASTSKPVAMAPVMALLDECRLRLDDPVEPWLPELADRR
                     VLTRIDGPLDDTVPAQRPVTVRDLVTSTFGIGIDLTAPSSPIMSAIFERGVYTQGAEPT
                     PEPDEWMRRLGTLPLMRQPGEHWQYHVSHDVLAVLVARVTGRPFETFLRERVLAPLGMK
                     DTGFHVPADDIDRLPPSYAPDPKTGEFLVWDEAAGGRYSRPPAFPSGGGGLVSTVDDYH
                     AYFRMLLRHGMHGTERILSRPAVQLMTTNRLTPEQQAARDALARNNVHVSFGQGLHGGW
                     GLGMAVRTHRGDYASVGQFGWDGGTGTTAYADPDKQLTGILLTQVGMSTPDSARLIHDF
                     WTTVYQAIDD"
     misc_feature    complement(9030..9032)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<9381..9878)
                     /locus_tag="AQI70_RS14570"
                     /old_locus_tag="AQI70_14560"
                     /pseudo=""
     CDS             complement(<9381..9878)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070691.1"
                     /locus_tag="AQI70_RS14570"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14560"
                     /product="DUF6624 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAHDVAALAEVLKAMAASDQRSSVHANSDDPAEQLAWRRLTARHG
                     DRLGEIMDEYGWPTAELVGEEAARSAWLIAQHADRQLHIQRRALQLMQQAVSAGAPGAR
                     ELAFLRDRTLVNEGRKQIYGTQIAGVKDGAPVPWPCEEPERMDELRAEVGIEPFDEYVA
                     KFA"
     gene            complement(10001..11398)
                     /locus_tag="AQI70_RS37415"
                     /old_locus_tag="AQI70_14565"
     CDS             complement(10001..11398)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="AQI70_RS37415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14565"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_062148869.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-23, bitscore: 79.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTASYTLVGFDPLGLAPADRPGLGPFTGTASPVLTTLDALRDRL
                     ADLAAAGRTGCVVAVLDADRAPEAVRLRQELNETVLAAGSPLVPCVVTDDRTLRIGPWV
                     RPHTTPCLACFARDLLPAPDGFRLDALPRPAVTDDRNEPTTKPDDLVAAGLQEALGTLR
                     TGLRDSPDRSVWGRVLSVRVQADGRLLRESWRAPRDPDCPSCGAPSGLPRLSRILHENS
                     KLHEHFRERDAIDSAHATAEPADQRPSPVHRLPDVQGIRSLPLEEAITRRRSRRRFGPS
                     ALDPADLSALLHYSSGVTGWGRTTDGGRIPLRAAPSGGALYPIDVYTYLRRVSGLPRGL
                     FRYDPLAHALVATGRPADAGERLSAHSAHREVLDDAAAIVLLAASFGRTQAKYLERGYR
                     ITLMEAGHIAQNLQLVATARRLRVCGVTGFVDDTVNDVLGLPAQGETQALYLLAVGRPL
                     TPAGSGA"
     gene            complement(11395..12483)
                     /locus_tag="AQI70_RS14580"
                     /old_locus_tag="AQI70_14570"
     CDS             complement(11395..12483)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS14580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQI70_14570"
                     /product="hypothetical protein"
                     /protein_id="WP_062148872.1"
                     /transl_table=11
                     /translation="MTDVGHLAELRGLERTVLTVTTPHHPTWLPVFPVAHLAEHLLGRE
                     LGRLPGLSALTGHLRRDLITVRFLTATAGPAAFDVRQLVDLRETARQDFEQERRVLAVE
                     DAILPPPLRTAGRLPASLAEFLDAWRRTEPRPRLERQPYLTDRLRELVDPAAPPHPYGT
                     TAPDPGPADPRQEHAEALAAVRRRTCGTPPELFLDGGPLEQYCGAGSVFLAGLSAYRSP
                     LFRGLREGPRPLYTLKLFDFPWRRRTFIACVTQPAIGPAEFAATLGARTVGLIAGLDDA
                     DLRTVLAEGRVAVLDDLAAVLDFPPRRAWLPVLARLNGFSARPADLARPVLDCTVDDLA
                     RYRDTFLDAYARHIHRTAREAV"
     gene            complement(12480..13343)
                     /locus_tag="AQI70_RS14585"
                     /old_locus_tag="AQI70_14575"
     CDS             complement(12480..13343)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS14585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQI70_14575"
                     /product="hypothetical protein"
                     /protein_id="WP_062148875.1"
                     /transl_table=11
                     /translation="MSAPAGHDRHAAATALHWLHRHPIDRRDAPALPLADEAWFHAMLL
                     ERFSTLCPADVPAWEGTLNALLDTARQPAPPAARQHPAAEADDLLGTAMLAHLLHVRAP
                     GDKAARHLVERLAPRLRTASLPPLHALCLAHNLHELGEHDLAGALRPPRDADQAAAGLT
                     GAERLLTQAYFHTHVVLFAFGTFRRPDADPAPLAGSVRFLRRHAPAFARYGWADLCAEA
                     ALSLSLCAARDEDFRLLIAALHGSQRPEGDWTHPRVDARQARHATMMASLALLESARHS
                     TAAARG"
     gene            complement(13340..14125)
                     /locus_tag="AQI70_RS14590"
                     /old_locus_tag="AQI70_14580"
     CDS             complement(13340..14125)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040270.3"
                     /locus_tag="AQI70_RS14590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14580"
                     /product="DUF5944 family protein"
                     /protein_id="WP_062148878.1"
                     /transl_table=11
                     /translation="MRHATTALVAGLMRKEEFSGRTLEEAMARYVISPTLAARTAAVHC
                     SVTGRLAAPGVVELRCTTRLDGLTEPFALKHTYTFPLLDEVRESGLVLRPETPAGTSEI
                     LVALKDGAKSYVNVAVHDDEGYMLYSSVLTYDRRGEVRPYVPVIPDKFTSPLSLGKAEL
                     GEAVDERGHRVLRLVLELEELTGPAVVKVGYNTLGIQEVRRFEAGPADPVVVSDLLLEN
                     NPELLPGEWVIGATDAEDRMLVNGIVRVAPMGGPRGATA"
     gene            complement(14122..15531)
                     /locus_tag="AQI70_RS14595"
                     /old_locus_tag="AQI70_14585"
     CDS             complement(14122..15531)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="AQI70_RS14595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14585"
                     /product="cytochrome P450"
                     /protein_id="WP_062148882.1"
                     /sec_met_domain="p450 (E-value: 3.7e-59, bitscore: 195.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNWKAIPLVSGAAACPAHPPGRPAGPGPGPGPGDEPPGRHLRELR
                     TAPLDLLRRAAHEGTHGLARLDAGPGACLVVNDPAAIDVVLADRDAVFFKPKMELWKRV
                     LGENVLTSEGPDWASSRRRSVRITGARYVRRAARIVAGAADERLRHWTGTDPLDIHEEM
                     RSLTLAATLRQLCGTDADFDLRAFSHHLRTVMECIHALESAPAAPAEHDDVRREFSRAA
                     TELRTSVLNLVAHHPGGRDDLIGLLTDAPGEPLTVRQVCDEVLAHLIAGHESTATSLAW
                     ALLLLAGDPAVTERVRTEIDTAVGDRAPEDADLARMPLLRAVFLEALRLYPPAWTIMRA
                     TGRPSVVGGVRIPAGAVLLVSPYGVQRSERWFEGPDEFRPERWLGGGRNGDPKYTFFPF
                     GGGRRSCPGRQLALVTGGVVLTRVLQGFSLAPVGDPLRAAVDIILRPRPGTRLRATPRQ
                     PEPAGHRKESR"
     assembly_gap    15643..16415
                     /estimated_length=773
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(16490..17890)
                     /locus_tag="AQI70_RS14600"
                     /old_locus_tag="AQI70_14590"
     CDS             complement(16490..17890)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="AQI70_RS14600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14590"
                     /product="YcaO-like family protein"
                     /protein_id="WP_159042661.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-58, bitscore: 194.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSTLPGTGQRDPRQGPPQGADGASGSASMSPLPEAHPLLDRII
                     RRERVFAAVPRVRRVPGDPAVYSHTCLPGPAVERLGRFGRYTKCGGAGFDPADSWIAAA
                     AEGLERFYAITYSTTAPYRRGRWSEHPDDFADPAKWAPFAPEQYAEPGFAFRPLTAESD
                     IRWYEGQDLLTGRQRWLPGPAVCFPYLRSRDEERVLPAVTTGLAFGLGPEHAARSALWE
                     VIERDALVLAWHWQLPVRRIDTTAGLPRELARTAELDDRCTVDAYDITSDLGVPACLVI
                     LRVADATGPILAAGSACRGSLQAALRKAFLEALQGVPYVRHLRATLAEGWTFGGDFAEV
                     SSFERSAAFYSLFPDQLKACLTARPEFLDVVGAPVRVEAHPEPTATLGLDETLKALDER
                     GHRAYAVDMSPQALRADGCAVVRVVVPGLYGLEGAHRFRSAHRARAEAVAALSGTTPDP
                     HPFPHPLP"
     gene            complement(17957..18091)
                     /locus_tag="AQI70_RS38515"
     CDS             complement(17957..18091)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997107.1"
                     /locus_tag="AQI70_RS38515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YM-216391 family RiPP peptide"
                     /protein_id="WP_107116988.1"
                     /transl_table=11
                     /translation="MFENTTAEIEEVDIEVGFIIGSTCCSLEMEEDDLDVAAEETEAV"
     gene            complement(18221..19048)
                     /locus_tag="AQI70_RS14605"
                     /old_locus_tag="AQI70_14595"
     CDS             complement(18221..19048)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997106.1"
                     /locus_tag="AQI70_RS14605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14595"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_244181632.1"
                     /transl_table=11
                     /translation="MKDSVAFEARALVQRHPHGVRLHLTRSADRYRADIVVDGGQGAAF
                     FDDGVSVNLEEFDRVCPAAGLWLDALAEELGVPRRFLGCSAFVSPVGSGLPLHFDDKDV
                     VVVQVSGVKRWRLADNTGLRYPTANYAAGSRYVSRELAGYYRPGSPGTEPPRHLDTVDL
                     RPGDALFLPRGHWHGTEAHEHTPSVSLSFGIATPSWSAVFLERLRLRLLTADHWRAPAV
                     RLDASHGRFAPADLVRRMDGAISDLMSGELDRALAGEITAGRAPDPAADVSGR"
     gene            19434..20903
                     /locus_tag="AQI70_RS14610"
                     /old_locus_tag="AQI70_14600"
     CDS             19434..20903
                     /GO_function="GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042245 - RNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033815.1"
                     /locus_tag="AQI70_RS14610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14600"
                     /product="3' terminal RNA ribose 2'-O-methyltransferase
                     Hen1"
                     /protein_id="WP_062148890.1"
                     /transl_table=11
                     /translation="MFLTISTTGTPDRPATDLGFLLHKHPEKAQAFSTSYGTAHVLYPE
                     ADAERCTAALLLEVDAVALVRRGKGKGRGGAPDAALAQYVNDRPYAASSLLAVALSGVF
                     SSAMRGVCNARPERAAQPLPLRIEIPALPARGGPELVRRLFEPLGWAVTAEPVPLDVRF
                     PEWGDSRYVRLVLASDTLTLAEALRHLYVLLPVLDDAKHYWVASDEVDKLLRAGEGWLP
                     DHPEHKLITSRYLSRRWSLTREAMERLELVRLAEADDSEVEEIDNAVEAESEAEEKPTP
                     LAVQRRDAILAALRASGAGRVLDLGCGQGQLVQTLLKDPAFTEIVGVDVSMRALTIAGR
                     RLKLDRMGERQASRVKLFQGSLAYTDNRLKGYDAAVLSEVIEHLDLPRLPALEYAVFGS
                     ARPRTVLVTTPNVEYNVRWESLPAGHVRHGDHRFEWTRDEFRAWARAVAERHGYEVEFV
                     PVGPDDPQVGPPTQMAVFGMKVNDEKEAKAA"
     gene            20900..23476
                     /locus_tag="AQI70_RS14615"
                     /old_locus_tag="AQI70_14605"
     CDS             20900..23476
                     /GO_function="GO:0004113 - 2',3'-cyclic-nucleotide
                     3'-phosphodiesterase activity [Evidence IEA]"
                     /GO_function="GO:0051731 - polynucleotide
                     5'-hydroxyl-kinase activity [Evidence IEA]"
                     /GO_process="GO:0042245 - RNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997104.1"
                     /locus_tag="AQI70_RS14615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14605"
                     /product="polynucleotide kinase-phosphatase"
                     /protein_id="WP_062148893.1"
                     /transl_table=11
                     /translation="MTQAANGRVLPVTDLSLVVLIGASGSGKSTFARRHFKPTEVISSD
                     FCRGLVSDDENDQSATRDAFDVLHYIAGKRLAAGRRTVVDATSLQQDARRQLIDLAKKY
                     DVLPIAIVLDVPEEVCAERNAARTDRADMPRRVIQRHTRELRRSLRHLEREGFRKVHVL
                     RGVDDIENATVVTEKRFNDLTHLTGPFDIIGDIHGCSAELESLLGKLGYVDGVHPEGRT
                     AVFVGDLVDRGPDSPGVLRRVMSMVKSGNALCVPGNHENKYGRYLKGRKVQHTHGLAET
                     IEQMEGESEEFRAQVREFIDGLVSHYVLDGGRLVVCHAGLPEKYHGRTSGRVRSHALYG
                     DTTGETDEFGLPVRYPWAEDYRGRAAVVYGHTPVPEATWLNNTICLDTGAVFGGKLTAL
                     RWPERELVDVPAEQVWYEPTKPLRTEAPGGHDGRPLDLADVHGRRVVETRHQGRVSIRE
                     ENAAAALEVMSRFAVDPRLLPYLPPTMAPTATSHIEGYLEHPAEAFAQYKEDGVERVVC
                     EEKHMGSRAVALVCRDAEAARRRFGVGGTSRSSEAESGGGPTGSLYTRTGRPFFDDESV
                     TETILERVRAAATAAGLWEELETDWLLLDAELMPWSLKASGLLRSQYAAVGAASGAVFP
                     GALAALEGAAARGIDVSDLLTRQRERASDAAAFTEAYRRYCWTTDGLDGVRLAPFQFLA
                     VQGRSLAALPHDEQLALLDRLVEHDGTGLLQTTRRLYVDTGDPESVRAGVDWWLEMTGR
                     GGEGMVVKPLGAVVRSGEGRLVQPGIKCRGREYLRIIYGPEYTRPDNLARLRQRFLNHK
                     RSLAIREYALGLEALDRLAEGEPLWRVHEAVFGVLALESEPVDPRL"
     gene            complement(23493..24392)
                     /locus_tag="AQI70_RS14620"
                     /old_locus_tag="AQI70_14610"
     CDS             complement(23493..24392)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385308.1"
                     /locus_tag="AQI70_RS14620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14610"
                     /product="NAD(+)/NADH kinase"
                     /protein_id="WP_062148896.1"
                     /transl_table=11
                     /translation="MSLAPRVVLVHRTTEYEELVARHGTHGQAAFFLSSRGRDIEEVAE
                     RHRRTGRALAEVASAVPVTWRQARVERADLDRFLFAPEDVVVVVGQDGLVANTAKYLAG
                     QPVLGIDTDPGRNPGVLVRHRPQDAAELLVATQSGRGDFDELTMVEAVADDTQRLVALN
                     EIYLGAVGHQTARYRLGLEDDGGVVEAQASSGVLIGTGTGATGWIRSVWQERGSGLPLP
                     RPTEDRLLWYVREAWPSPATGTSLVAGELTTATRLRLTVESERLVAFGDGMETDAVELT
                     WGQTVRVGVCAQRLRLAG"
     gene            complement(24389..25459)
                     /locus_tag="AQI70_RS14625"
                     /old_locus_tag="AQI70_14615"
     CDS             complement(24389..25459)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997102.1"
                     /locus_tag="AQI70_RS14625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14615"
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_062148899.1"
                     /transl_table=11
                     /translation="MADITRRLGRRHLRAAPTAHIRHHRAGKLLHDGPGLSFWFRALTA
                     ALSEVPVDDRELAMTFHARTSDFQDVAVQATVTYRISDPAVAATRLDFSIDPDTGAWRG
                     TPLEQLGTLLTESAQQHALDVLARTPLSAALVDGVAAVRERITAGLAEEPRIPATGIEV
                     VAVRVVALRPEPEVERALRTPAREQIQQEADRATYERRAVAVERERAIAENELASQIEL
                     ARREEQLVEQRGTNARREAEEHAAADAVRAEAEAARTVRLAEAEAARTVRLTQAEATRS
                     VRLARAEAEGAREVGEARARAQAAWLRVHAEVDVATLHALAGTKVAENLPRIDSVTVSP
                     DVLTGLLARLGGQGPA"
     misc_feature    25478..25498
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 29.81"
                     /tool="antismash"
     misc_feature    complement(25512..25532)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 27.43"
                     /tool="antismash"
     gene            25587..26810
                     /locus_tag="AQI70_RS14630"
                     /old_locus_tag="AQI70_14620"
     CDS             25587..26810
                     /EC_number="3.5.3.6"
                     /GO_function="GO:0016990 - arginine deiminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006527 - arginine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125172.1"
                     /locus_tag="AQI70_RS14630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14620"
                     /product="arginine deiminase"
                     /protein_id="WP_062148902.1"
                     /transl_table=11
                     /translation="MGFHVDSEAGRLRRVILHRPDLELKRLTPSNKDALLFDDVLWVRR
                     ARAEHDGFADVLRDRGVTVHLFGELLTEALEIPAARKLVLDRVFDEKEYGVLATDHLRA
                     AFEGLPSRELAEALVGGMTKREFLEAHPEPISVRFHVMELDDFLLAPLPNHLFTRDTSA
                     WIYDGVSVNAMRWPARQRETVHFEAIYRHHPLFREETFHVWSEGQADYPSTIEGGDVLV
                     IGNGAVLIGMSERTTPQAVEMLAHKLFAAGSAQTIVALDMPKRRALMHLDTVMTMVDGD
                     VFTQYAGLGMLRSYTIEPGAGDKELKVTDHPPEHMHRAIAAALGLSEIRVLTATQDVHS
                     AEREQWDDGCNVLAVEPGVVVAYERNSTTNTHLRKQGIEVIEIPGSELGRGRGGPRCMS
                     CPVEREPV"
ORIGIN
        1 cagccgtgga gcgcccgcgt cggacagggt gtcccagaag ccggacccgt tgtcgggcgc
       61 gtcaccgtcg ccgaacgtgc tggtgatgaa gagcaggtcg gccgtgcggg cgagggcgcg
      121 gacgtcggcc tcgtccatgc cgaccagggt ggtccggtgc ccggcggcgc ccagccgctc
      181 ggcggtggcg gtggcgaacc cctcggcgtt gccggtctgc gaggcccaca gcacgacgac
      241 ctcacggccc ggccgcgtcc gcggcccggc cgccgtgcgc gagtacatgc cggccaggac
      301 gccgttcacc cacagcgcgt gctcggggct gaagggcgcg tccggcggga gcaccgggac
      361 acccggcgcg ccggagtcga tcccggcgag aaacccggtg aggtagaggc gttcctgtgc
      421 ggacagcacg ggcggcggcg cgggctccag cccgaagggg tcggccgtgc cgggggtgac
      481 cgctgtaggc gtcagcgcct cgaccggcct gcccggcacg ggagccgcca ccttcgccag
      541 ggaaacggca cacaccttga actcgggctg gaaggagatc ggatccaccg cgtcgctggt
      601 caccgcgttg acgctcagat actccccgaa caggtcgttc cagtggaacg gcgcgaaaca
      661 gcaccccggc cgcacccgct cggtcaccac cgccggcagc accgcccgcc cccgacgaga
      721 ggcgacctcc acctggtccc cgtcggcgat ccccagctca gccgcgtcct gcggatgcac
      781 ctccacgaac ggccccgggt tcagcttgtt gagcttggcg accttccccg tcttcgtcag
      841 cgtgtgccac tggtgctgca cccgcccggt gttcagcacg aaggggtagt cgtcgtccgg
      901 cagctcggcg ggcggcaggt gcggccgggc gtggaaggcg gctcgcccgc tcgcggtcgg
      961 gaaccgcagc ccgccgtccg ggtcgacgta ccggatcgga ttgcgctccg gcccctccgc
     1021 gtcggcggcc ggccactgca cgggcgtggc ccgcagccgc tcgtacgtca ccccgcgcag
     1081 atcccacccc gtcaccgggt tccaggcccg ccgtatctcc tcgaagacct cctcggcact
     1141 ctcgtacgag aaccccttct cgtaccccat ggcacaggcg acggccgcga tgattcgcca
     1201 gtcggccatc gcctcgcccg gcgggtcggc caccggctgg gtcagggtga gattgcgctc
     1261 gctgttgacg aagacgccct cgccctcggt ccacatcgcg ccgggcagga ccacatcggc
     1321 gtacgcgttg gtctcggtct cggcgaagac gtcctgggcg acgacgaact ccgcggcttc
     1381 caggccctcg atgaccgtac ggcggttggc gaccgaggcg acggggttgg tgcagatgat
     1441 ccagcaggcc ttgatctcgc cgtcggccat cttctggaac atctcgatcg tgcccttgcc
     1501 gacgccgtcg gcgcgcaggg tgcccggcgg cagctcccac agctcctcga cgaaggcccg
     1561 ctcggcgtcc acggcgacgg accgctgccc cggcagcccc ggccccatgt accccatctc
     1621 acgcccgccc atcgcgttgg gctgcccggt gagggagaag ggcccgctgc cgggacggca
     1681 gatggctccc gtggccagat gcaggttgac cagggcgttc gtgttccagg tgccgtgcgt
     1741 ggactggttg agccccatcg tccagcagct catccactcg cccgcctcgc cgatcagccg
     1801 ggcggccgtg cgcaggtcct cctcggcgat cccggtgatc tccgcgacgg cgtccggcgt
     1861 gtagtcgccg agaaactccg ccatcgcctc ccagccctcg gtgtgggcgg cgatgaagcc
     1921 ggggtcggtg tggccgttct cgacgagcag gtgcaggagg ccgttgagga gggcgaggtc
     1981 ggtgcccggc ttgagctgca ggtagaggtc ggccttggcg gcggtggcgg tgcgtcgcgg
     2041 gtcgaccacg atgagtttcg cgcccgcctt gacccgttcc atcatgcgca ggaagaggat
     2101 ggggtggcag tcggccatgt tcgagccgat gaccaggaag acgtccgcct tgtcgaagtc
     2161 ctcgtacgac ccgggcggcc cgtccgcgcc gagggacagc ttgtagccca tgcccgcgct
     2221 ggccatgcac agccgggagt tcgactcgat ctggttggta cggacgaagc ccttggccag
     2281 cttgttcgcc aggtactggg cctccaggct catctgcccc gagacataga aggcgacggc
     2341 gtccggcccg tgctcgtcga tgatcgcgcg cagccggcgg gccgtctcgg cgatcgcgtc
     2401 ggccgtcggg gagggtatcg gctcctcgcc cgggtcgtcc ctgaccagcg cggtggtcag
     2461 ccggccgggc gcggcgagca tctcggccgt ggtcgcgccc ttcgtgcaca gccggcccgc
     2521 gttcgccggg tgcgccttgt ccccggacgc cttcagcacc gtacgccgcc cgtcgggtcc
     2581 catcccgacg tccagcagga ttccgcagcc caccccgcag tacgtgcaga ccgtccggac
     2641 ctgagtcgtg gaggtggtcg aggtcacgtg ctgcccttct ccggcggtac gaggtgatgt
     2701 ctggagcgta cgaattgccc gttacgtcga tgtcacatcc cttgatcatg aggagttacg
     2761 tcggccacac agccgcccgt ggcgcgatgt gaggggtgcg ggacggcgcg gtgcggtcgc
     2821 gcatcgtgtc gctgttgggc cgaacgggtg acatggcgta agaattggct ggtgcaggca
     2881 ttgaaggcga gtcaggtcgg gggggagccg gtgaacagcc acgacgtcac cgatgaacag
     2941 tgggaagggc tcgcccaggt cgtgccgttg cgcggccgtg acgcctggcc gtccgcggtc
     3001 gaccatcgtg tcgccccgga ggcggagacg gagccgcggc gccggttcgt cgtcctgcgg
     3061 gtcaatgtgt tcgcggacgc ccgtgaggtc gccgagacgc tgatggcggg cattccggtg
     3121 ctgctggacc tgaccggggc ggagaccgag gtcgccaaac gggtcctcga cttcagtacg
     3181 ggcgtcgtct tcgggctggc gagcgggatg catcgggtcg accggaacgt gtttctgctc
     3241 acgccgcccg ggaccgaggt gagcggcttg atggaggggg ccggggttcc cggcacctga
     3301 gcgggcccgg cggacgggtc ggtcgctcga tcgtaggaag agcctcgggg tggaacggtt
     3361 cgtctgacga ccggggccct acggtccgga catggccgtg ccgtcttcct ctgctgccgc
     3421 ttccgtcccg tctgtcgcac cttccggggg cgtcgggaca caccccgacc ggccacgcgt
     3481 caccgaactg cggttgtcgg ccttcgcggg gcaccggcgt gccgggtttc ccctcggcac
     3541 gctcacgctt ctcgccgggc ccagcgggtg cgggaagacg agcgcgctgc gggcgtacga
     3601 ggccctggcc cggctcggcg gtggggacgc ggtcggtgcg gtgttccccg atccgggcgc
     3661 gtgtgtaccc gagcgtgcgc ggcccgatgc ccagcgccgg cgtggcttcc ggatcggctg
     3721 cacggcggac ggacccgagg gcccggtccg gctcgacgtc gccgtgcagg ccgagcccga
     3781 actgcgcatc gtgggggagc ggctgagcgc gggcggtgtc gttctgctgg agacggccct
     3841 gcgggatccg agccggccct gggtgcaggc cgcctggcac acggccggtc agtccccggt
     3901 gacccgcggg ccgctgcccg acgaccggct gggcaccgct ctgctgccgc tgcgggtggc
     3961 gggcaggacg gccggacagc ggcgggtgct cgccgccgcg gagcagatgg tggtggcgct
     4021 gcggtcggtc ttcgcctgcg atccgcggcc cgggcggatg cgggcgcctg tgccgaccgg
     4081 ttccgggcgg ctgctcggtg gctgcgacaa cctcgccgat gtgctgtggc gtacgcgggc
     4141 ggagtgcggg cggcggcatc agcagttcgt cgcggcggtg cgggcggggt gtgcgggggc
     4201 ggtggcggac gtgctggcgg aggcgctgcc cggcggggtg gtgcggggcg tggtcgagcg
     4261 gggggacggg ttccgtacgg agctcgggcg gctgggcgac ggtgagctgc ggtatctcgc
     4321 gctctgcctg gtgctgctga ccgggcccgg ggtgctggag gtcgatccgg ccggtgaggt
     4381 gcccgcggcc atgcagacgc tgactgtgct ggccgacggg ttcgaccggg ggctggatcc
     4441 ggggcagcgg ggggagttgg tgcggctggc ggcccggatg tgcgggcggg ggcatatccg
     4501 ggtggtcggg gcggtgagcg acgcgtcgtg ggtcgagggg gtggacgggg tgacggtggt
     4561 agacctgagt ccgtgactgg agagcctgga gagtcccgac cgctcgatct ggcggcgctg
     4621 cagcgaaggc tggccgagtt cgccgccgcg cgcgactggc agccgtatca cacgccgaag
     4681 aacctcgtcg cggcgctgag cgtggaggcg tccgaactgg tcgagatctt ccagtggttg
     4741 acgccggagg agtccgcgcg ggtcatggac gacgccgaga ccgcggggcg ggtgaccgat
     4801 gaggtcgccg atgtgctggc gtatctgttg caactgtgcg aggtgctcgg gatcgatccg
     4861 ttggcggcgc tggacgcgaa gatcgaccgg aacgagcgga ggtttccggc gccgtagggg
     4921 gcgtacggga gggcgtggga ggggcgtcgg gagggggagg cgcgaggtcc gctttcactc
     4981 tctgtgttcg ttcggagggt tgtagccgaa aagttgtccg cagatttccg tcttcctctg
     5041 gcttttcgtc tcaggggcct tcactctggg tagtggataa gggagttcgg gttctggtgg
     5101 acgcgtgggc agcgcgtcgg gacagacggg gacagcggat ggacgcggtg cggctcatcg
     5161 ggacgagcag gcgggcgctg gccgggagca ggcgggtgcc cgagatcatg accgaggtgt
     5221 ggcaggcgca ggccctggct caggcgatcg gcagccggct cgcggtgttc ggtccacctg
     5281 aactgcgggg cgaggcgctg gggttgacgg agttggcggg gcgtggctgc ggggtgctgg
     5341 acacgccgga gctggcggat ggggacttgc gtgcggctca gctcacggag ctgggtgatg
     5401 cccggcaggc gctgatgagt ctggggagtc tgctggggga ggtcgggatc gcccttgtcg
     5461 gtatggccag tgcctcggat gacgagggga cgtactggca gtgcatggaa gcgatcgacg
     5521 cggcggacga gtcccgggac cgggtgctgg agatgctgcg aagactggcg gatcgggagc
     5581 aggtgctgcc ggagagggag gcggggtagt gggggtgcgc gtgcgaatgc ctgcggcggc
     5641 ctgtggcggt tgggtggggg ttcgcgtagc gcctgcggtg cggttgtggg tcggggccgc
     5701 gccgggggtg tccgtcctcg gaccggcggc tggggcgggc caggaggtgc cgcgtgttga
     5761 cgccggccac tgcgggcgga caccccccga cacgtcccct tcccgccgtg ggcgactgcg
     5821 gcgccgcggg ggtacgcgcc atcgccgcgc cttttcgctg ccggtagccg gtcccgagtt
     5881 tgaggacgag gccccttcat ggccgaagca ggcacccagc agggtccgtg ccgacgccga
     5941 ggatctcagc cgacgccgtc accccgcggc gcctggtggc ccggtccggt cggcgcaggg
     6001 cgccctgcgc ctccggtcga ctgcagatcc gcgtccaggg ccgacaggtc cgcgttcagc
     6061 gctgccatca gttcctccat ctgctgcagc agccccttct gcgggccggg gccgccggcc
     6121 tgctgcggtg tgagttcctc ggacatgacg gcctcctcgg cctgcggccc cgtgggtagt
     6181 gggccgacca ggtgacgctc cggcgtcagc ggccggggcg ggcgccgggc ggtccggctc
     6241 cgagggagcc aacgatcacc gtcgggggcg gtcactggta cgggcagggg gcggcttcgg
     6301 cgttgacgga attcacccga ccggggactc gcgggcaggg gggaccggtg ccgttgaccg
     6361 gtggcgtggt gtgcaggatg gagtcatgga tcttcgcatc ttcaccgagc cccagcaggg
     6421 ggccacctac gagaccttgc tcagcgtggc gaaggccacc gaggaccttg ggttcgacgc
     6481 gttcttccgc tccgaccact atgtgaagat gggctccggg gacggactgc ccggacccac
     6541 cgacgcctgg atcacgctgg ccggtctcgc gcgcgagacc aagcggattc gcctcggcac
     6601 cttgatgacc gccggcacct tccggctgcc cggcgtgctc gccatccagg tcgcccaggt
     6661 cgaccagatg tccggcgggc gtgtcgaact cggcctgggg gccggctggt tcgaggagga
     6721 gcacaaggcg tacggcatcc ccttcccgaa ggagaagttc gggcggctgg aggagcagct
     6781 cgccatcgtc accgggctgt gggcgaccga ggtcggggac accttcgact tccacgggac
     6841 gtactacgac ctcaccgatt cccccgccct gcccaagccc gcccaggacc gcattccggt
     6901 tctgatcggc gggcacggcg ccacccgtac gccgcggctg gccggcaggt acgccgacga
     6961 gttcaacatg ccgttcgcct cggtcgagga cagcgagcgg cagttcgggc gggtgcgggt
     7021 cgccgccgag gaggccggac gcaaggggga cgacctcgtc tactccaacg cgctggtggt
     7081 gtgtgtgggg aaggacgatc aggaggtcgc ccgccgtgcc gccgcgatcg ggcgtcaggt
     7141 cgacgagctg aagctcaacg ggctcgccgg ctccccggac gaggtcgtcg acaagatcgg
     7201 ccggtaccag gagatcggtt cggcgcggat ctacctccag gtcctcgatc tggacgacct
     7261 ggaccacctg gagctcatct cctcccaggt ccagtcgcag ctgtcgtagg gcgggaggta
     7321 cagatccggc catatgctgc tttcccccgg gaactccgga gtgcctgcaa tgggtgatgc
     7381 gttatcaagg agacgggtca acaccgattg aggtggttga ccgtcttgtt gccgcgactc
     7441 gcaagctgca aggaacccgg ggggcttcag ctgtgttctc acgcatgttg ttgaatctgg
     7501 aacagcaaac cgaaggccgc ggcgtcggcg ccgtccggct gggagtgccg gtccactccc
     7561 gtcggtgcgt cctgcgccaa cagatcggcg ccttcatcga acaccggctg ggggacccgg
     7621 agctgacccc ggcggcgatc gccgaggccc accacatctc ggtgcgctat ctgtaccagg
     7681 tcttcgacac ccaccagatg accgtcgccg cctggatccg gcactgccga ctggagcact
     7741 gccaccgcga tctggcggat ccacggctgc gtacgcggtc catccgggcg atcgcctccc
     7801 gctggggctt ctcggatgcg gcgcacttca gccgggcctt cagggccgcg tacgggatgt
     7861 ctcccagcga ccatcgccaa ctggccctcg ggcacggtta ggggcgtggg tccagggtct
     7921 acgggggcgc ccggccggtg tcagtcgtcg atcgcctggt agaccgtggt ccagaagtcg
     7981 tggatgagcc gcgccgaatc cggcgtggac atcccgacct gggtcagcag gatgccggtg
     8041 agctgcttgt ccgggtcggc gtaggccgtg gtgccggttc cgccgtccca gccgaactgg
     8101 cctacggacg cgtagtcacc gcgatgggtg cgcaccgcca tcccgaggcc ccagccgccg
     8161 tgcagcccct ggccgaacga cacatggacg ttgttgcggg ccagggcgtc ccgggcggcc
     8221 tgctgctcgg gcgtgaggcg gttggtggtc atcagctgga cggcgggccg ggacaggatc
     8281 cgttcggtcc cgtgcatccc gtgacgcagc aacatccgga aataggcgtg gtagtcgtcg
     8341 acggtggaga ccagcccacc gccgcctgac gggaacgccg gaggccggct gtaccgtccg
     8401 cctgccgcct cgtcccacac gaggaactct ccggtcttcg ggtccggggc gtagctgggc
     8461 ggcagccggt cgatgtcgtc ggcgggcacg tggaagccgg tgtccttcat ccccaaggga
     8521 gcgaggacgc gctcgcgcag gaacgtctcg aacggccggc ccgtgaccct cgcgacgagc
     8581 acggcgagca catcgtggct gacgtggtac tgccagtgct ctccgggctg ccgcatcagc
     8641 ggaagcgtgc ccaggcggcg catccactcg tccggctcgg gcgtcggctc cgccccctgg
     8701 gtgtagacgc cccgctcgaa gatcgcggac atgatcggag agctcggcgc ggtcagatct
     8761 atgccgatcc cgaacgtgga ggtcaccagg tcccgtacgg tgaccggccg ctgtgccggc
     8821 acggtgtcgt ccagcgggcc gtcgatccgc gtcagcaccc ggcggtcggc gagttcgggc
     8881 agccacggct ccaccgggtc gtccagccgc agcctgcact cgtcgagaag ggccatcacc
     8941 ggcgccatcg cgaccggctt ggacgtggac gccatccgga agatcgtgtc ccggcgcatc
     9001 ggcgcgccac cgtcatggcg catcgtccct aatgcttcga cgtgcgtctc accgccgcgg
     9061 tcgaccagcg cgacgagtcc gggaatcctc ccggactcga cgtgccgtgc cagtacgtcg
     9121 cgcactctgc gcaggcctgc cgcggagaag ccgcccttgc ccgttcccat catgagtctc
     9181 cctgcatgca atgtttggga attgctgaac gctcacgacg ctatattgcg ttcagtgatt
     9241 cgtcaacgat gggttggggg cgcaatttgc ttgttggtga gccaggttgg gtgggtgcgt
     9301 tgcaatgagt gtgacgctga acgcaatggg tggcctgggg cgggtattgc gatggagtct
     9361 gccttactcc tggggggcgg tgcgaacttg gcgacgtact cgtcgaaggg ctcgatgccg
     9421 acttccgcgc gcagttcgtc catgcgctcg ggctcttcgc agggccacgg aaccggtgct
     9481 ccgtccttca cgccggcgat ctgcgtgccg tagatctgct tgcggccctc gttgacgagc
     9541 gtacggtcgc gcaggaaggc gagttcgcgt gcgccgggcg cgcctgccga taccgcctgc
     9601 tgcatcagtt gcagggcgcg tcgctggatg tggagctgtc ggtcggcgtg ttgggcgatc
     9661 agccacgcgg agcgagcggc ctcctcgccg acgagttccg ccgtgggcca gccgtactcg
     9721 tccatgatct cgccgagccg gtcgccgtgc cgtgcggtca gccggcgcca cgccagctgt
     9781 tcggccgggt cgtcgctgtt cgcgtgaacg gaggaccgct ggtcgctcgc ggccatggcc
     9841 ttgagtacct ccgccagtgc ggcaacgtcg tgcgccactc tcaactccca ggatcggtcg
     9901 acgtgttgtg tgcgtcatcg gcaaccctag ggggcatatc gggcgtaaag atcattccgg
     9961 ggaacggtga caggcacctc ggcgagcggc gataatggat ctacgccccg gagccggccg
    10021 gcgtgagcgg gcggccgacg gccagcagat acagggcctg ggtctcgccc tgggccggga
    10081 gtcccagtac gtcgttgacg gtgtcgtcga cgaagccggt caccccgcac acccgcaagc
    10141 gccgggcggt cgcgacgagt tgcaggttct gcgcgatgtg cccggcctcc atcagcgtga
    10201 tccggtagcc ccgttcgagg tatttcgcct gtgtccggcc gaaggacgcg gcgagcagca
    10261 cgatcgccgc ggcgtcgtcg agtacctcac gatgcgccga gtgggccgac agccgctcgc
    10321 cggcatcagc cggacgcccg gtcgcgacga gggcgtgcgc gagggggtcg taccggaaga
    10381 ggccccgcgg caggcccgac acccggcgca gatacgtgta cacgtcgatc gggtacagcg
    10441 caccgcccga cggcgccgcg cgcagcggga tccggccgcc gtccgtggtc ctgccccagc
    10501 cggtgacgcc ggaggagtag tgcagcaggg cggagaggtc ggccgggtcc agggcggacg
    10561 gtccgaaacg gcggcgggaa cggcggcggg tgatcgcctc ctccagcggc agcgaccgta
    10621 tgccctggac gtcgggcagg cgatgcaccg gggacggtcg ctgatcggcg ggctcggcgg
    10681 tggcgtgggc gctgtcgatc gcgtcccgtt cccggaagtg ctcgtgcagc ttgctgttct
    10741 cgtgcaggat ccgggagagg cggggcaggc cgctcggcgc gccgcaggac gggcagtccg
    10801 ggtccctggg cgcccgccac gactcccgta gcagccgtcc gtcggcctgg acgcgcaccg
    10861 acaggacacg gccccacacc gaccggtcgg ggctgtcccg cagcccggtg cgcagggtgc
    10921 cgagcgcctc ttggagaccg gccgcgacca ggtcgtccgg tttggtcgtc ggctcgttgc
    10981 ggtcgtcggt gacggcgggc cggggcagcg cgtcgagtcg gaagccgtcc ggggcgggga
    11041 gcaggtcccg ggcgaaacag gccaggcagg gtgtggtgtg cggccggacc caggggccga
    11101 tgcgcagggt gcggtcatcg gtcacgacac agggcacgag gggggagccc gcggcgagca
    11161 cggtctcgtt gagttcctgc cgcagccgta ccgcctccgg cgcgcggtcg gcgtccagga
    11221 cggccacgac acagccggtc cggcccgccg ccgcgaggtc cgcgaggcgg tcgcgcagtg
    11281 cgtcgagggt cgtcaggacg gggctcgcgg tgccggtgaa ggggccgagc ccggggcggt
    11341 cggcgggggc caggcccagc gggtcgaagc cgacgagggt gtacgaggcg gtggtcatac
    11401 ggcctcccgg gcggtgcggt ggatgtgccg ggcgtacgcg tcgaggaagg tgtcgcggta
    11461 ccgggcgagg tcgtcgacgg tgcagtcgag caccgggcgg gcgagatcgg cgggccgcgc
    11521 gctgaagccg ttgagacgcg ccagcaccgg cagccaggcc cgccggggcg ggaagtccag
    11581 tacggcggcc aggtcgtcga gtacggcgac tcggccctcg gcgagcaccg tgcgcaggtc
    11641 ggcgtcgtcg aggccggcga tcaggccgac cgtgcgggcg ccgagcgtgg cggcgaactc
    11701 ggccgggccg atggcgggtt gggtgacgca ggcgatgaac gtgcgccgcc gccacgggaa
    11761 gtcgaacagc ttcagggtgt agaggggacg cgggccttcc cgcagcccgc ggaagagggg
    11821 ggagcggtag gcggagagtc ccgcgaggaa gaccgagccc gccccgcagt actgctccaa
    11881 cgggccgccg tccaggaaca gttccggtgg ggtgccacag gtcctgcggc gtacggcggc
    11941 cagcgcctcg gcgtgctcct ggcgggggtc cgcggggccg gggtcgggag ccgtcgtacc
    12001 gtacgggtgc ggtggtgcgg cggggtcgac gagttccctc agccggtccg tgaggtaggg
    12061 ctgccgctcc agccggggcc ggggttccgt ccgacgccat gcgtccagga actcggcgag
    12121 cgacgccggg agccgtcccg cggtgcgcag cgggggcggc aggatcgcgt cctccacggc
    12181 gaggacgcgc cgctcctgct cgaagtcctg ccgggccgtc tcccgcaggt ccaccagctg
    12241 ccggacgtcg aacgcggccg gtccggccgt ggcggtgagg aagcgtacgg tgatcaggtc
    12301 ccggcgcaga tgaccggtca gggcgctcag gccggggagc cggcccagct cccgtccgag
    12361 gaggtgctcg gcgaggtggg cgacggggaa gacgggcagc caggtcggat ggtgcggggt
    12421 ggtgaccgtc aggaccgtcc gctccaggcc gcgcagctcg gcgaggtgcc ccacgtcggt
    12481 catccccgtg ccgccgccgt cgagtgccgc gccgactcca gcagggccag ggacgccatc
    12541 atggtggcgt gccgggcctg gcgggcgtcg acgcgcgggt gcgtccagtc gccctccggg
    12601 cgctgcgagc cgtgcagcgc cgcgatgagc aggcggaagt cctcgtcgcg tgccgcgcac
    12661 agggagaggg acagcgccgc ctcggcgcac aggtccgccc agccgtaccg ggcgaaggcg
    12721 ggggcgtgcc ggcgcaggaa gcgaacgctg cccgcgagcg gcgcggggtc cgcgtcgggc
    12781 ctgcggaagg tgccgaaggc gaacagcacc acatgggtgt ggaagtaggc ctgggtcagc
    12841 agccgttcgg caccggtgag gcccgctgcc gcctgatcgg cgtcccgcgg cgggcgcagg
    12901 gcgccggcca ggtcgtgttc gccgagctcg tgcaggttgt gcgccaggca cagggcgtgc
    12961 aagggcggca gggaggccgt cctcaggcgc ggggcgagcc gctcgaccag gtgccgggcg
    13021 gccttgtcgc cgggagcccg gacgtgcagc aggtgggcga gcatcgcggt gcccagcagg
    13081 tcgtccgcct cggcggcggg gtgctgccgg gcggcgggcg gagccggctg ccgcgccgtg
    13141 tccagcaggg cgttcagagt gccttcccag gccggtacgt cggcgggaca gagggtggag
    13201 aaacgttcga gcagcatggc gtggaaccac gcctcgtcgg cgagcggcag ggcgggcgcg
    13261 tcccgccggt cgatcgggtg ccggtgcaac cagtgcagcg ccgtggccgc cgcgtgccgg
    13321 tcgtgcccgg cgggtgcgct catgccgtcg ctccgcgcgg tccgcccatg ggggccaccc
    13381 ggacgatgcc gttgacgagc atgcggtcct cggcgtcggt cgctccgatc acccactcgc
    13441 ccggcagcag ctcggggttg ttctccagca gcaggtccga gacgaccacc ggatcggcgg
    13501 gaccggcctc gaaacggcgt acctcctgga tgcccagggt gttgtagccg accttcacca
    13561 cggccggacc ggtcagctcc tccagctcca gcacgagccg cagcacccgg tggccccgct
    13621 cgtcgaccgc ctcgcccagc tcggccttgc ccagggacag cggggaggtg aacttgtccg
    13681 ggatcaccgg cacatagggg cggacctcgc cgcggcggtc gtaggtgagc accgaggagt
    13741 agagcatgta gccctcgtcg tcgtgcacgg cgacgttgac gtagctcttg gccccgtcct
    13801 tgagcgcgac caggatctcg ctggtgccgg cgggcgtctc ggggcgcagc accagccccg
    13861 actcccgcac ctcgtccagc agcgggaagg tgtacgtgtg cttgagcgcg aagggctcgg
    13921 tgagcccgtc cagccgggtg gtgcagcgca gctccaccac gcccggcgcg gcgagccggc
    13981 cggtgaccga gcagtgcacg gcggccgtac gggcggccag ggtgggcgag atgacgtacc
    14041 gcgccatggc ctcctccagc gtccggccgg agaactcctc cttgcgcatc agccccgcga
    14101 ccagcgcggt cgtcgcatgc ctcatcgtga ttcctttcgg tgtccggcgg gttccggttg
    14161 cctgggggtc gcccgcagcc gggtgccggg acggggacgc aggatgatgt ccacggcggc
    14221 ccggagcggg tcgccgacgg gtgccaggga gaagccctgc agcacccggg tgagcaccac
    14281 gcccccggtg accagggcca gttgacggcc ggggcaggag cggcggccgc ccccgaaggg
    14341 gaagaacgtg tacttcggat caccgtttcg cccgccgccc agccagcgct ccggccggaa
    14401 ctcgtcgggc ccctcgaacc agcgctccga gcgctgcacg ccgtagggag agaccagcag
    14461 gaccgccccg gccgggatgc gtacgccgcc gaccacgctg ggccggccgg tggcccgcat
    14521 gatcgtccag gcgggcgggt acagccgcag cgcctccagg aagaccgccc gcagcagcgg
    14581 catacgggcc aggtccgcgt cctcgggggc ccggtcgccg acggccgtgt cgatctccgt
    14641 gcgcacccgc tcggtcaccg ccggatcacc ggcgagcagc agcagcgccc aggcgagcga
    14701 ggtggccgtg gactcgtgcc cggcgatgag gtgggcgagg acctcgtcgc acacctgccg
    14761 cactgtcagc ggctccccgg gggcgtcggt gagcaggccg atcaagtcgt cccggccgcc
    14821 gggatgatgg gccacgagat tcagtacgga ggtcctgagc tcggttgcgg cacggctgaa
    14881 ctccctgcgg acgtcgtcgt gttcggccgg ggcggcgggc gcggactcca gggcgtggat
    14941 gcactccatc accgtgcgca gatggtgcga gaaagcgcgc aggtcgaagt cggcgtcggt
    15001 gccgcacagc tggcgcaggg tcgccgcgag ggtgagcgac cgcatctcct cgtggatgtc
    15061 gagcgggtcc gtgcccgtcc agtggcgcag ccgctcgtcg gcggccccgg cgacgatccg
    15121 ggcggcgcgc cggacgtacc gcgccccggt gatgcggacg ctccggcgcc gtgaactcgc
    15181 ccagtcgggg ccctcgctgg tgagcacgtt ctcgccgagc acgcgcttcc acagctccat
    15241 cttcggtttg aagaagacgg cgtcgcggtc ggcgagcacg acgtcgatgg ccgccgggtc
    15301 gttcaccacg agacaggcgc cggggcccgc gtccagccgg gccagaccgt gcgtgccctc
    15361 gtgtgccgcg cggcgcagca ggtccagcgg tgcggtgcgc agctcgcgca gatggcggcc
    15421 cggcggctcg tcgccgggac cggggcccgg gccggggccg gcgggccggc cgggtggatg
    15481 tgccgggcag gccgccgcgc cgctcaccag gggaatggcc ttccagttca tcgcgggcac
    15541 ctcggggcgt cggtcacggc agggcgcggt cggggcgggc gtgcggatcg gggtcgtggt
    15601 cggggcgggg ggtgcggatc ggggtcgtgg tcggggcggg ggnnnnnnnn nnnnnnnnnn
    15661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnggccg ggtcgtggtc agggccgggg
    16441 gtgcgggccg ggtcgtggtc agggcagggg gtgcgggcct ggtacgtagt cagggcaggg
    16501 ggtgcgggaa ggggtggggg tcgggcgtgg tgcccgacag cgcggccacg gcctcggcgc
    16561 gggcgcgatg ggcgctgcgg aagcggtggg cgccttcgag gccgtacagg ccgggcacga
    16621 cgacccggac gacggcacag ccgtcggcac gcagggcctg cggactcatg tcgacggcgt
    16681 aggcgcggtg cccccgctcg tcgagcgcct tcagggtctc gtcgaggccg agggtcgccg
    16741 tcggctcggg gtgggcctcg acgcggacgg gcgctccgac gacgtcgagg aactccgggc
    16801 gggccgtgag gcaggccttc agctggtccg ggaacaacga gtagaaggcc gcgctgcgtt
    16861 cgaaggagct cacctcggcg aagtccccgc cgaaggtcca cccctcggcg agggtggcgc
    16921 gcagatgccg tacgtagggc accccttgca gggcctccag gaaagccttg cgcagggcgg
    16981 cctggaggct gccccggcag gccgagcccg cggccaggat cgggccggtg gcgtcggcca
    17041 cccgcaggat caccaggcag gcggggacgc cgaggtcgga ggtgatgtcg taggcgtcga
    17101 cggtgcagcg gtcgtcgagt tcggcggtcc gggccagctc gcgggggaga ccggcggtgg
    17161 tgtcgatcct gcgcacgggc agctgccagt gccaggcgag caccagggcg tcccgctcga
    17221 tcacctccca cagcgccgag cgggcggcgt gctcgggacc gagcccgaag gcgaggcccg
    17281 tggtgacggc cggcaggacg cgctcctcgt cccgggaccg gaggtaggga aagcacacgg
    17341 ccgggccggg gagccaccgc tgccgtccgg tcaacaggtc ctggccctcg taccacctga
    17401 tgtcgctctc ggcggtcaac ggccggaagg caaagccggg ttcggcgtac tgctccggcg
    17461 cgaacggagc ccactttgcc gggtcggcga agtcgtcggg gtgctcgctc cagcgccccc
    17521 gccggtaggg cgcggtcgtg ctgtaggtga tggcgtaaaa gcgctccagc ccctcggccg
    17581 ccgccgcgat ccagctgtcg gcggggtcga agcccgcgcc gccgcacttg gtgtaccggc
    17641 cgaagcggcc gagccgttcc acggccgggc cgggcaggca ggtgtggctg tacacagccg
    17701 gatcgcccgg gacgcggcgc acccggggca ccgcggcgaa gacccgctcg cggcggatga
    17761 tccggtcgag cagagggtgc gcctcgggca gcggtgacat cgacgcgctg cccgaggcgc
    17821 cgtccgcgcc ctgcggaggt ccttgacggg ggtcgcgctg tccggttccg ggcaatgtgc
    17881 tccccgtcat gcgggactcc attccatggg tgcggtggtg tgccggagaa ttaccgagga
    17941 cttaccggtt caccggtcag acggcctcgg tctcctcggc ggcgacgtcc aggtcgtcct
    18001 cttccatctc cagggaacag caggtcgacc cgatgatgaa tccgacctcg atgtcgactt
    18061 cctcgatctc ggcggtcgtg ttctcgaaca tttctgtctc ccgtctccgg tcatcactga
    18121 ccggtcaatt ggctcggtcc tcaactgccg gtgattcccc gggtcttcga cgactggcaa
    18181 tctcgaccag cccgcaggac cgggggattt cctccggcct tcaacgaccg ctgacatcgg
    18241 cggccgggtc cggtgcccgg cccgccgtga tttccccggc cagtgcccgg tcgagttcac
    18301 cggacatcag gtccgagatc gccccgtcca tccgccggac cagatccgcg ggcgcgaacc
    18361 gcccgtggct cgcgtccagc cggacggccg gggcccgcca gtggtcggcg gtcagcagcc
    18421 ggagcctgag ccgctccagg aagaccgccg accatgacgg agtcgcgata ccgaacgaca
    18481 gcgacacgga gggcgtgtgc tcgtgggcct cggtgccgtg ccagtggccg cggggcagga
    18541 acagggcgtc cccgggccgc agatcgacgg tgtcgagatg ccgcggcggc tcggtcccgg
    18601 gggaaccggg ccggtagtag ccggccagct cccgggacac ataacggctg ccggcggcgt
    18661 agttggcggt gggatagcgc agcccggtgt tgtcggcgag ccgccaccgc ttgacgccgc
    18721 tgacctggac gaccaccacg tccttgtcgt cgaagtgcag cggcagcccg ctgccgaccg
    18781 gcgacacgaa cgccgagcag cccaggaacc gccgcgggac gcccaactcc tcggccagcg
    18841 cgtccagcca gaggccggcc gccgggcaga cccggtcgaa ctcctccagg ttcaccgaga
    18901 ccccgtcgtc gaagaaggcg gcgccctgcc cgccgtcgac gacgatgtcg gcccggtacc
    18961 ggtccgccga acgcgtcaga tgcagccgta cgccgtgcgg atggcgctga accagggcgc
    19021 gggcctcgaa ggccacagaa tccttcattc cgtcgaggat ttccggtccg ccgctcccgg
    19081 tgatccgccg gccttccgca aaggccttcc ggacttcctc cgccccggcc ccgggaaaga
    19141 gaacggagag tgccccgccc ttgaccgcgc gtgcttcctc ctcggccatg ggtatctctg
    19201 ccctgtcccc gcgctgcacc atctgcctgg cccccgcccg tccttttcgg tttctgtcca
    19261 ggagattgcc gcagccgccg gagtgaagtc gttgacggcg cgtgcgcagc agttgtctat
    19321 ttctgcacat gccggccggg tcggcgcacg cgggaaaatg cgtgcgtacg tatggacggt
    19381 tggctgtacg ttgtggtgtc cgcagctcag accacatcca gaggcaaccc accgtgttcc
    19441 tgacgatcag taccaccggc acaccggacc gcccggccac cgatctcggc ttcctgctgc
    19501 acaagcaccc cgagaaggcc caggcgttct ccacctccta cggcacggcg cacgtcctct
    19561 accccgaggc ggacgccgag cgctgcacgg cggcgctgct gctggaggtc gacgcggtgg
    19621 cactggtccg gcgcggcaag ggcaagggcc ggggcggcgc ccccgacgcg gccctcgcgc
    19681 agtacgtcaa cgaccgcccg tacgcggcct cctcgctgct ggccgtggcg ctgagcggcg
    19741 tcttctccag cgcgatgcgc ggcgtgtgca acgcccggcc ggagcgcgcc gcccagccgc
    19801 tgccgctgcg catcgagata cccgcgctgc ccgcccgggg cggcccggaa ctggtacgac
    19861 gcctcttcga gccgctcggc tgggcggtga ccgccgagcc cgtgccgctg gacgtgcggt
    19921 tcccggagtg gggcgactcg cggtacgtcc gtctcgtcct cgcgtcggac acgctgaccc
    19981 tcgccgaggc cctgcgccat ctgtacgtcc tgctgcccgt cctcgacgac gccaagcact
    20041 actgggtcgc ctccgacgag gtcgacaagc tgctgcgggc cggtgagggc tggctgccgg
    20101 accacccgga gcacaagctc atcaccagcc ggtatctgtc gcgccgctgg tcgctgaccc
    20161 gggaggcgat ggagcgactg gagctggtgc ggctcgcgga ggccgacgac agcgaggtcg
    20221 aggagatcga caacgccgtc gaggccgaga gcgaggccga ggagaagccg accccgctcg
    20281 ccgtgcagcg ccgggacgcg atcctggccg cgctcagggc gtccggtgcc gggcgcgtgc
    20341 tcgatctcgg ctgcggtcag ggccagttgg tgcagaccct gctcaaggac ccggcgttca
    20401 ccgagatcgt gggcgtggac gtgtcgatgc gggcgctcac catcgccggg cggcggctga
    20461 agctggaccg gatgggcgag cggcaggcct cgcgcgtgaa gctcttccag ggctccctcg
    20521 cctacaccga caaccggctc aagggctacg acgccgccgt gctcagcgag gtcatcgagc
    20581 acctcgacct gccgcggctg cccgccctgg agtacgccgt cttcggttcg gcccgcccga
    20641 ggaccgtcct cgtgacgacc ccgaacgtcg agtacaacgt ccgctgggag agcctcccgg
    20701 ccggacacgt ccggcacggc gaccaccgct tcgagtggac ccgcgacgag ttccgcgcat
    20761 gggcgcgggc ggtggccgaa cggcacgggt acgaggtgga gttcgtaccc gtgggacccg
    20821 atgacccgca ggtgggtccg cccacccaga tggccgtgtt cggcatgaag gtcaacgacg
    20881 agaaggaggc gaaggccgca tgactcaggc agcgaacggg cgtgtcctgc ccgtcaccga
    20941 cctctccctc gtcgtcctga tcggcgcctc cggctccggc aagtccacct tcgcccgcag
    21001 gcacttcaag cccaccgagg tcatctcctc cgacttctgc cgcggcctcg tctccgacga
    21061 cgagaacgac cagagcgcga cgagggacgc cttcgacgtc ctgcactaca tcgcgggcaa
    21121 gcgcctggcc gccggccgcc gtacggtcgt cgacgccacc agcttgcagc aggacgcccg
    21181 gcggcagctg atcgacctgg ccaagaagta cgacgtgctg ccgatagcca tcgtgctcga
    21241 cgtccccgag gaggtctgcg ccgagcgcaa cgcggcccgc accgaccggg ccgacatgcc
    21301 gcgccgggtc atccagcggc acacccgtga actgcgccgg tcgctgcgtc acctggagcg
    21361 cgagggcttc cgcaaggtgc acgtcctgcg gggcgtggac gacatcgaga acgccaccgt
    21421 cgtcaccgag aagcgcttca acgacctgac ccacctcacc ggccccttcg acatcatcgg
    21481 cgacatccac ggctgctccg ccgaactgga gtcgctgctc ggcaagctgg gctacgtcga
    21541 cggcgtccac cccgagggcc gtacggccgt cttcgtcggc gacctcgtcg accgcggccc
    21601 ggacagtccc ggcgtgctgc gccgcgtgat gtcgatggtg aagtcgggca acgcgctgtg
    21661 cgtgccgggc aaccacgaga acaagtacgg gcgttacctc aagggccgca aggtccagca
    21721 cacgcacgga ctcgccgaga ccatcgagca gatggagggc gagagcgagg agttccgcgc
    21781 gcaggtgcgg gagttcatcg acgggctggt cagccactac gtcctcgacg gcggccggct
    21841 ggtggtctgc cacgccggtc tgccggagaa gtaccacggc cgcacctccg gccgggtccg
    21901 ctcgcacgcg ctgtacggcg acaccaccgg ggagaccgac gagttcgggc tgccggtgcg
    21961 ctacccgtgg gcggaggact accggggccg ggcggccgtg gtgtacggcc acactccggt
    22021 cccggaggcc acctggctga acaacaccat ctgcctggac accggcgccg tcttcggcgg
    22081 caagctgacc gcgctgcgct ggccggagcg ggaactggtc gacgtaccgg cggagcaggt
    22141 ctggtacgag ccgacgaagc cgctgcggac ggaggcgccc ggcggacacg acggccgccc
    22201 gctcgacctg gcggacgtcc atgggcgcag ggtcgtcgag acccggcacc agggccgcgt
    22261 ctcgatccgt gaggagaacg cggcggcggc cctggaggtc atgagccgct tcgcggtcga
    22321 cccgcgcctg ctgccgtacc tcccgccgac gatggcgccg acggcgacca gccacatcga
    22381 gggctacctc gaacaccccg cggaggcctt cgcgcagtac aaggaggacg gcgtcgagcg
    22441 ggtcgtgtgc gaggagaagc acatgggttc gcgggccgtg gccctggtgt gccgcgacgc
    22501 ggaggcagcg cgcaggcgct tcggtgttgg gggtacctcc cgctcgagcg aagccgagag
    22561 tgggggaggc ccgaccggct ccctctacac ccgcaccggg cgcccgttct tcgacgacga
    22621 gtcggtgacg gagacgatcc tggagcgggt ccgggccgcg gcgaccgctg cggggctgtg
    22681 ggaggaactg gagaccgact ggctgctgct cgacgccgag ctgatgccgt ggtcgctgaa
    22741 ggcgtcgggc ctgctgcgct cgcagtacgc ggcggtcggc gccgcctccg gcgcggtgtt
    22801 cccgggtgcg ctggccgcgc tggagggcgc ggcggcacgc ggcatcgacg tctcggacct
    22861 gctgacgcgc cagcgcgaac gggcctcgga cgcggccgcg ttcacggagg cgtaccggcg
    22921 ctactgctgg accacggacg gcctggacgg cgtacgcctg gcccccttcc agttcctggc
    22981 ggtccagggc cgcagcctcg ccgcactccc gcacgacgag cagctcgcgc tcctcgaccg
    23041 gctggtggag cacgacggca ccggcctgct ccagaccacc cgacggctgt acgtcgacac
    23101 cggtgacccg gagtcggtgc gggccggcgt ggactggtgg ctggagatga ccggccgggg
    23161 cggcgagggc atggtcgtca agccgctcgg cgcggtggtg cgcagtggcg agggccgtct
    23221 ggtgcagccc ggcatcaagt gccggggccg ggagtacctg cggatcatct acggtccgga
    23281 gtacacccgc ccggacaacc tggcccggct gcggcagcgg ttcctcaacc acaagcgctc
    23341 cctcgcgatc cgcgagtacg cgctcggtct ggaggccctg gaccgcctgg ccgagggcga
    23401 gccgctgtgg cgggtgcacg aggccgtgtt cggggtgctg gccctggagt cggagccggt
    23461 ggacccgcgg ctgtgatccg ggaggcgcgg tttcagccgg ccagccgcag ccgctgagcg
    23521 cacacgccca cccggaccgt ctgcccccag gtcagctcga ccgcgtccgt ctccatgccg
    23581 tccccgaagg cgacgagccg ctccgactcg acggtgaggc gcagccgggt cgcggtggtg
    23641 agctccccgg ccaccagtga ggtaccggtg gccggggacg gccaggcctc gcggacgtac
    23701 cacagcagac ggtcctcggt ggggcggggc agcggaaggc cgctgccccg ctcctgccac
    23761 accgaccgga tccagccggt cgcccccgtc ccggtgccga tgagcacccc ggacgaggcc
    23821 tgggcctcga cgacaccccc gtcgtcctcc aggcccaggc ggtatctggc cgtctggtgt
    23881 ccgacggcgc ccaggtagat ctcgttgagc gccaccaggc gctgtgtgtc gtcggcgacg
    23941 gcctcgacca tggtgagttc gtcgaagtcg ccccttccgg actgcgtggc cacgagcaac
    24001 tcggcggcgt cctgcgggcg gtgccgcacc aggacgcccg ggttgcggcc ggggtcggtg
    24061 tcgatgccga gcaccggctg tccggcgagg tacttggcgg tgttcgccac cagcccgtcc
    24121 tgcccgacca cgaccacgac gtcctccggg gcgaacagga agcggtccag gtcggctcgc
    24181 tcgacccgcg cctgacgcca cgtcaccggc acggccgagg cgacctcggc gagcgcccgt
    24241 ccggtgcggc ggtgccgttc cgcgacctcc tcgatgtccc ggccacggga ggagaggaag
    24301 aaggcggcct ggccgtgcgt gccgtgccgg gcgaccaact cctcgtactc cgtggtgcgg
    24361 tggacgagga cgacccgggg agcgaggctc acgccggccc ctgtccaccg agcctggcca
    24421 gcaacccggt cagcacgtcc ggcgacaccg tcacgctgtc gatccgcggc aggttctcgg
    24481 cgacctttgt cccggcgagc gcgtgcagcg tcgccacgtc cacctccgcg tgcacccgca
    24541 gccaggccgc ctgcgcccgc gcccgcgctt caccgacctc acgcgccccc tcggcctcgg
    24601 cgcgggccag ccgtacggac cgggtggcct ccgcctgcgt gagccgcacc gtccgcgcgg
    24661 cctccgcctc ggccagccgt accgtccgcg cggcttccgc ctcggcccgc accgcgtcgg
    24721 ccgcggcatg ctcctcggcc tcacgccgcg cgttcgtccc ccgctgctcc accaactgct
    24781 cctcgcggcg ggcgagttcg atctggctgg ccagttcgtt ctcggcgatc gcgcgttccc
    24841 gctcgacggc gaccgcgcgc cgctcgtagg tcgcccggtc ggcctcctgc tggatctgct
    24901 cgcgggccgg ggtgcgcagt gcccgctcca cctccggttc cggccgcagg gctacgacgc
    24961 gtacggcgac cacctcgatg ccggtcgccg ggatccgggg ctcctcggcc aggcccgccg
    25021 tgatccgctc ccgcaccgcc gcgaccccgt cgaccagcgc cgccgacagg ggcgtacggg
    25081 ccaggacgtc cagcgcgtgc tgctgtgccg actccgtcag aagcgtcccc agctgctcca
    25141 gcggggtgcc ccgccaagcg ccggtgtccg ggtcgatgga gaagtccagc cgcgtcgcgg
    25201 ccaccgccgg gtcgctgatc cggtaggtga ccgtcgcctg gacggccacg tcctggaagt
    25261 cggacgtacg ggcatggaag gtcatcgcca actcccggtc gtcgaccgga acttcggaga
    25321 gcgctgcggt cagggcccgg aaccagaagc tcaggccggg gccgtcgtgc agcagctttc
    25381 cggcgcggtg gtggcggatg tgggccgtgg gcgcggcgcg cagatggcgc cggccgaggc
    25441 gccgggtgat gtcggccatg gagatgcagc cccctctttt tcgtcatgta gacgataagc
    25501 aggcgtcctg gttgtcgtca aggggacgaa aagaagaagg gggcaagcag ggggtgaagg
    25561 cggctcccga tggtcaggat ggagacatgg gattccatgt cgactccgag gccgggcggc
    25621 tgcgccgcgt catcctgcac cggccggatc tcgagctcaa aaggctcacc cccagcaaca
    25681 aggacgccct gctcttcgac gacgtgctgt gggtgcgccg ggcgcgcgcc gagcacgacg
    25741 ggttcgccga cgtgctgcgc gaccgcgggg tcaccgtcca cctcttcggc gagctgctca
    25801 ccgaggccct ggagatcccg gcggccagga agctcgtcct cgaccgggtc ttcgacgaga
    25861 aggagtacgg ggtgctcgcc accgaccacc tccgtgcggc cttcgagggc ctgccctcac
    25921 gcgaactggc cgaggccctg gtcggcggga tgaccaagcg ggagttcctg gaggcgcacc
    25981 ccgagccgat ctccgtgcgc ttccatgtca tggagttgga cgacttcctg ctggcccccc
    26041 tgcccaacca cctcttcacc cgggacacct ccgcctggat ctacgacggc gtctccgtca
    26101 acgccatgcg ctggccggcg cggcagcgcg agacggtcca cttcgaggcg atctaccggc
    26161 accatcccct cttccgtgag gaaacgttcc acgtctggtc cgaggggcag gccgactacc
    26221 cctccaccat cgagggcggg gacgtgctgg tgatcggcaa cggcgcggtc ctcatcggga
    26281 tgagtgagcg gaccaccccc caggccgtcg agatgctcgc ccacaagctg ttcgccgccg
    26341 ggtcggcgca gaccatcgtg gcgctcgaca tgcccaagcg gcgcgccctc atgcacctcg
    26401 acaccgtgat gacgatggtc gacggcgatg tcttcaccca gtacgccggg ctcggcatgc
    26461 tccgctcgta caccatcgaa ccgggcgccg gcgacaagga gctgaaggtc accgaccatc
    26521 cgccggagca catgcaccgc gcgatcgccg ccgccctggg cctcagcgag atccgcgtcc
    26581 tgaccgcgac ccaggacgtc cactcggccg aacgcgagca gtgggacgac ggctgcaatg
    26641 tgctggccgt cgagccgggg gtcgtcgtcg cctacgagcg caactccacc accaacacgc
    26701 atctgcgcaa gcagggcatc gaggtgatcg agatcccggg cagcgagctg gggcggggga
    26761 ggggcgggcc gcgctgtatg agctgtccgg tcgaacggga gcccgtgtag ccgcagggtc
    26821 gaaccgcacg ggtcgagccg cacgggtcga accgctcggg tcgaaccgct cgggtcgaac
    26881 gcggggccgt atagaaattc tgaagctcgt atagacttcc agagttccct gttctcgcac
    26941 ctctggagcg ccccccatgg cgacagtccc gaccgccctc gccggccgcc acttcctcaa
    27001 ggagctcgac ttcaccgagc agcagttcct cgggctggtc gagctggccg ccgagctgaa
    27061 ggccgccaag aaggccggga ccgagaccca gtacctgcgg ggcaggaaca tcgcgctgat
    27121 cttcgagaag acctcgacgc gcacccgctg cgcgttcgag gtcgcggccg ccgaccaggg
    27181 cgcctcgacg acgtacctcg acccgtccgg ctcgcagatc gggcacaagg agtccgtgaa
    27241 ggacaccgcg cgcgtgctgg gccggatgta cgacgcgatc gagtaccgcg gggacagcca
    27301 ggccaaggtg gaggagctgg cgcagtacgc cggcgtgccc gtctacaacg gcctcaccga
    27361 cgactggcac cccacccaga tgctcgccga tgtgctcacc atgaccgagc acacgagcaa
    27421 gcccgtcaag gagatcgcct tcgcctacct cggcgacgcc cgtttcaaca tgggcaactc
    27481 ctacctggtc accggcgccc tgctcggcat ggacgtgcgc atcgtcgcgc ccaaggagta
    27541 ctggccgggt gacgaggtcg tcgcccgggc ccgcgagctg gcggagggca gcggcgccgt
    27601 catcacgctc accgaggacg tcggcgaggg cgtgcggggg gccgacttcg tcgccaccga
    27661 tgtgtgggtc tccatggggg agcccaagga ggtctgggac gagcggatcg ccgcgctcgg
    27721 ctcttacgcc gtgaccatgg atgtactgcg ggccacgggc aatcccgacg tcaagttcct
    27781 gcactgcctg cccgcgttcc atgacctcgg cacgaaggtc gggcgggaga tcttcgacag
    27841 ccatggtctg gagtcgctgg aggtgaccga cgaggtgttc gagtcggcgc
//
