LOCUS       NZ_KQ947985            20744 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s002, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ947985
VERSION     NZ_KQ947985.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 931730)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 931730)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 722872
            Orig. end                         :: 743616
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ947985.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20744
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="3"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20744
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20744
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10744](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10744)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    312..332
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.04"
                     /tool="antismash"
     gene            complement(1428..2180)
                     /locus_tag="AQI70_RS08835"
                     /old_locus_tag="AQI70_08820"
     CDS             complement(1428..2180)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825304.1"
                     /locus_tag="AQI70_RS08835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08820"
                     /product="SLATT domain-containing protein"
                     /protein_id="WP_062146560.1"
                     /transl_table=11
                     /translation="MGQPEMQPERSPQDGRGGEGAAGLRPGDLMGRAFPLGDWGEPAVR
                     LDELYRWVERGALNTAAWYLADRVWKRRAARALRGGAAAGAIVGAALPLLDMTGVASGV
                     APWGYLALLLAVACVAIDRFFGVTSGWIRDVATAQAVQRRLQALQFDWATECVREILGP
                     AEGTASEAAERCLGVLRRFTEDVTELVRAETADWMVEFRTGSAPLGIQSAVAGGARQDV
                     GVGQGRFSVPPANGARPNMPRQRPPEPR"
     misc_feature    2197..2210
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.19"
                     /tool="antismash"
     misc_feature    complement(2198..2211)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.03"
                     /tool="antismash"
     gene            2513..2857
                     /locus_tag="AQI70_RS08840"
                     /old_locus_tag="AQI70_08825"
     CDS             2513..2857
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985981.1"
                     /locus_tag="AQI70_RS08840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08825"
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="WP_079051204.1"
                     /transl_table=11
                     /translation="MIPGGGQPNMQQLLQQAQKMQQDLQRAQEELARTEVEGQAGGGLV
                     KATVTGAGELRALQIDPKAVDPEDTETLADLIIAAVQAANENAQNLQQQKLGPLAQGLG
                     GGSGIPGLPF"
     misc_feature    2915..2933
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.18"
                     /tool="antismash"
     gene            2949..3548
                     /gene="recR"
                     /locus_tag="AQI70_RS08845"
                     /old_locus_tag="AQI70_08830"
     CDS             2949..3548
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020124031.1"
                     /locus_tag="AQI70_RS08845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08830"
                     /product="recombination mediator RecR"
                     /protein_id="WP_030053254.1"
                     /transl_table=11
                     /translation="MYEGVVQDLIDELGRLPGVGPKSAQRIAFHILQAEPTDVRRLAQA
                     LMEVKAKVRFCATCGNVAQEELCNICRDTRRDPAVICVVEEPKDVVAIERTREFRGRYH
                     VLGGAISPIEGVGPDDLRIRELLARLADGTVTELILATDPNLEGEATATYLARMIKPMG
                     LKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV"
     gene            3541..4203
                     /locus_tag="AQI70_RS08850"
                     /old_locus_tag="AQI70_08835"
     CDS             3541..4203
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004985387.1"
                     /locus_tag="AQI70_RS08850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08835"
                     /product="DUF5063 domain-containing protein"
                     /protein_id="WP_062146166.1"
                     /transl_table=11
                     /translation="MSDATLHATEQNPDDFAVQIADQIESFLVAVTEVAKGDEPGSTVP
                     FLLLEVSQLLLAGGRLGAHEDIVPDERYEPDLGPEPDVDELRENLARLLDPVDVYSEVF
                     DPYEPRKAPVPARISDDLADVITDLRHGMAHYRAGRTTEALWWWQFSYFSNWGSTASAT
                     LRALHSVLAHVRLNQPLEELDGLDTDQGVMGDETLEFEAGKVMEQEIGEQLGLRPAQ"
     misc_feature    complement(4235..4250)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            4362..4778
                     /locus_tag="AQI70_RS08855"
                     /old_locus_tag="AQI70_08840"
     CDS             4362..4778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383604.1"
                     /locus_tag="AQI70_RS08855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08840"
                     /product="SsgA family sporulation/cell division regulator"
                     /protein_id="WP_062146169.1"
                     /transl_table=11
                     /translation="MHVTLEQPTGARLITAADQAIAIPATLRYTSADPLAVHLDFPPHV
                     TVDGEVTTWTFARTLLAEGLRAPAGPGSVRVRPCGASHTYVEFHSPAGTAVLRFTTSDL
                     YRFLARTYTVIAPGEETVGAELDQGLAALFGGRV"
     gene            4850..5203
                     /locus_tag="AQI70_RS08860"
                     /old_locus_tag="AQI70_08845"
     CDS             4850..5203
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032017.1"
                     /locus_tag="AQI70_RS08860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08845"
                     /product="hypothetical protein"
                     /protein_id="WP_244181527.1"
                     /transl_table=11
                     /translation="MTGALGLVVGGVLDVGAADPWASVAGGAAGLIGLAVTLYAFLGPA
                     PTAAAVTASGTRAVAAGGSIGAVSTGDGTSTTPPPPTTPGSPTRPASGPVTASGERSVA
                     AGGDIGSVSAGDG"
     gene            complement(5270..6001)
                     /locus_tag="AQI70_RS08865"
                     /old_locus_tag="AQI70_08850"
     CDS             complement(5270..6001)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999286.1"
                     /locus_tag="AQI70_RS08865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08850"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_062146171.1"
                     /transl_table=11
                     /translation="MTGEWAGDILLAGVVLLGSSVQWLTGMGFALVAVPALVLLLGPTQ
                     GVVLANCAAGVISVVGLAGGWRRVRMGAMVPLCAAAACTVPAGTWLTRQLPEPVLLLTM
                     GGLVTLAVLLIMRGARVPALRGAKGAVAAGAVGGFMNSAAGVGGPPVSLYAVNAGWTVR
                     EFVPNAMFYGVVVNAFSVASNGVPGLSGAQWVLVAAAMGAGGLIGRGLASRIPEGRARL
                     LVLLLALTGGVTAVGKGLWGL"
     gene            6195..6698
                     /locus_tag="AQI70_RS08870"
                     /old_locus_tag="AQI70_08855"
     CDS             6195..6698
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483781.1"
                     /locus_tag="AQI70_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08855"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_062146173.1"
                     /transl_table=11
                     /translation="MTRRSVSKRVAVVTATAVVAVGTFAAGVGVAGTGGDDKAASKKQI
                     AGLFDQWNSTLQTGDPKKVADLYASDAVLLPTVSNKVRSDRAAIVDYFEHFLANKPVGK
                     KIETHVNVLDGNSAIDAGVYQFTLTDKATGEKSVVKARYTYAYEKRNGEWKIVNHHSSK
                     LPEG"
     gene            complement(6664..8022)
                     /locus_tag="AQI70_RS08875"
                     /old_locus_tag="AQI70_08860"
     CDS             complement(6664..8022)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483782.1"
                     /locus_tag="AQI70_RS08875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08860"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_062146175.1"
                     /transl_table=11
                     /translation="MNRQLIRSYILLVAVAIFLFTVPVAFTLTKQLRDDTELSVLREAK
                     TMALLLGNSDTTSCDALTKVAKAYGAETPGNVQVTPTSSCAPDLPKPAADAALTRAVER
                     NEPTTDWGSDFIWGKHLTITVPVPAQGDAAVRIVYSTSDMTTRLWQIWGFRAALALLVL
                     AAAAAIGAFVARRITAPLRELNSMASKFSDGDLTARSPVTGPPETQTLARTLNQGAERL
                     DTLVASQRIFVADASHQLRTPLTALRLSLDNIADGVDDEFVREDVEQATAEVVRMSRLV
                     NGLLVLARAEAKVTAAEPLPLMDIVRERLAVWRPAADERGVTIALRGSADGRPSVLASP
                     GALDQVLDNVLSNALEVSPDGGTITVRVEPRGEVVDVSILDEGPGMSDAEKSRAFDRFW
                     RGQGLTGKSGSGLGLAVVKQLVTDDGGTVTLTDAPGGGLKVTISLRAASRSGG"
     gene            complement(8019..8735)
                     /locus_tag="AQI70_RS08880"
                     /old_locus_tag="AQI70_08865"
     CDS             complement(8019..8735)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006373446.1"
                     /locus_tag="AQI70_RS08880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08865"
                     /product="response regulator transcription factor"
                     /protein_id="WP_062146177.1"
                     /transl_table=11
                     /translation="MRVLLVEDDEPVAESLRRGLLRYGFEVAWVTTGAAALSHDAPYDV
                     VLLDLGLPDTDGLDVCKALRERGDVPIIVISARSDETDRVVGLELGADDYVSKPFGVRE
                     VIARIRAVMRRLQPRTPAAAAEAGPDRYGPRLTIDRKAARVRLDGEEVSLAPKEYDLLA
                     FLTEEPGALMSREQIMEAVWDANWFGPTKTLDVHVAALRRKLAGAITIEAVRGVGFRLE
                     IVRDAKGGDGEGSDAS"
     misc_feature    complement(8782..8795)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(8824..10011)
                     /locus_tag="AQI70_RS08885"
                     /old_locus_tag="AQI70_08870"
     CDS             complement(8824..10011)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999282.1"
                     /locus_tag="AQI70_RS08885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08870"
                     /product="cytochrome P450"
                     /protein_id="WP_062146179.1"
                     /sec_met_domain="p450 (E-value: 2.1e-18, bitscore: 62.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTEALIDFPFSWRGDQIPAEVEELRANAPVRRVRTIAGDEAWLV
                     SSYELCKQVLEDPRFSLKDTSAPGVPRQYALTIPPEVVNNMGNITGAGLRKAVLKALNP
                     KSPGLAEWMRSYAAELVDGLVREGAPVDLRGGFADPYSAGMHCRILGIPLADAPRLMRS
                     LDIAFMNSACPIAGARLNWDRDIAYMTERLDDPATMGLMGELAALRADPDYAHLTDEML
                     ATVGVTMFGAGVISTSGFLAMALVSLIQHPELHARLLADRTLVPAAVDELLRINLSIGD
                     GLPRLATEDVRLGDVEVRAGDLVLVLVEGANFDPAAFPDPHTVDLGRENATAHLSFGGG
                     RHYCPATALGRKHAEIALDTLLERMPGLRLAVPIEQLVWRTGFMKRIPERLPVMW"
     gene            complement(10001..10744)
                     /locus_tag="AQI70_RS08890"
                     /old_locus_tag="AQI70_08875"
     CDS             complement(10001..10744)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999281.1"
                     /locus_tag="AQI70_RS08890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08875"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_079051206.1"
                     /sec_met_domain="CDPS (E-value: 8.7e-85, bitscore: 279.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPEIQHVTRADTEADSPAGLFDVQPFTPHCEVIRAAGDHAVIG
                     VSPGNSYFSARRVHDLARWGLALFERVDFVYTDLYVAEMYAASGYPPDDARRKAVKNLR
                     GVRAKVLGAVQAVDPDGTRLRAHAMSDFHGNPAYREIHDHLQARLATDGAFHATCEKLV
                     DSFLAGRAGRATDAQREVCLAYVCAEAPLFLDTPAILDVPSSLNCYHQLLPMAELLYAR
                     GAGLRASRNQGHAIVTPAEGTTDAD"
     misc_feature    complement(11005..11019)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     gene            11314..12606
                     /locus_tag="AQI70_RS08900"
                     /old_locus_tag="AQI70_08885"
     CDS             11314..12606
                     /EC_number="2.7.2.4"
                     /GO_function="GO:0004072 - aspartate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063111.1"
                     /locus_tag="AQI70_RS08900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08885"
                     /product="aspartate kinase"
                     /protein_id="WP_062146183.1"
                     /transl_table=11
                     /translation="MGLVVQKYGGSSVADAEGIKRVAKRIVEAKKNGHQVVAVVSAMGD
                     TTDELIDLAEQVSPMPAGRELDMLLTAGERISMALLAMAIKNLGHSAQSFTGSQAGVIT
                     DSVHNKARIIDVTPGRIRDSLDEGNIAIVAGFQGVSQDSKDITTLGRGGSDTTAVALAA
                     ALDAEVCEIYTDVDGVFTADPRVVKKAKKIDWISFEDMLELASSGSKVLLHRCVEYARR
                     YNIPIHVRSSFSGLQGTWVSSEPLVRKTQQQGDKQVEQAIISGVAHDTSEAKITVVGVP
                     DKPGEAAAIFRTISDAEINIDMIVQNVSAASTGLTDISFTLPKAEGRKAIDALEKNKSG
                     IGFDSLRYDDQIGKISLVGAGMKTNPGVTADFFTALSDAGVNIELISTSEIRISVVTRA
                     DDVNEAVRAVHTAFGLDSDSDEAVVYGGTGR"
     gene            12603..13655
                     /locus_tag="AQI70_RS08905"
                     /old_locus_tag="AQI70_08890"
     CDS             12603..13655
                     /EC_number="1.2.1.11"
                     /GO_function="GO:0004073 - aspartate-semialdehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007383614.1"
                     /locus_tag="AQI70_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08890"
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="WP_062146185.1"
                     /transl_table=11
                     /translation="MTRRPTLAVVGATGAVGTVMLQILSQRADIWGEIRLIASPRSAGR
                     KLAVRGEEDEVVALTEEAFAGVDIAMFDVPDDVAARWAPIAAAKGAVVVDNSGAFRMDP
                     DVPLVVPEVNPHAVRMRPRGIVANPNCTTLSMIVALGALHAEFGLRELVVSSYQAVSGA
                     GRAGVETLRQQLSLVAGTDLGTSPGDVRRAIGENTGPFPEPVALNVVPWAGSLRADGWS
                     SEEMKVRGESRKILGLPQLPVAVTCVRVPVLTGHSLTVHARFEGEVTVAKAREILATAP
                     GVVLYDDPEAGEFPTPADVVGTDPTWVGRVRRALDDPTALELFVCGDNLRKGAALNTAQ
                     IAELVAAEFL"
     misc_feature    complement(13734..13749)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.83"
                     /tool="antismash"
     misc_feature    13852..13861
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     gene            14056..14736
                     /locus_tag="AQI70_RS08910"
                     /old_locus_tag="AQI70_08895"
     CDS             14056..14736
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007500632.1"
                     /locus_tag="AQI70_RS08910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08895"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_079051207.1"
                     /transl_table=11
                     /translation="MAEVLDFSAATRGTALRPPRRPVRSRMPGAPGGMPVIAPMPAARP
                     ARIPSQRDGADAESTAAAGTTVDHLTETYRAHYRSLLGLAALLLDDTASCEDVVQEAFI
                     RVHSARKRVRDPEKTLAYLRQTVVNLSRSALRRRILGLKLLSKPMPDMASAEEGAYDQL
                     ERDSLIRAMKGLQRRQREVLVLRYFADMTEAQVAETLGISLGSVKAYGSRGIAALRVAM
                     EAPA"
     gene            14856..15896
                     /locus_tag="AQI70_RS08915"
                     /old_locus_tag="AQI70_08900"
     CDS             14856..15896
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999275.1"
                     /locus_tag="AQI70_RS08915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08900"
                     /product="hypothetical protein"
                     /protein_id="WP_062146187.1"
                     /transl_table=11
                     /translation="MNHGPDDQGPEGLDSDELALRRILHQAVEEIEPRDGTLDHLRRAV
                     PARRARKRQALVGAAAAVLFLGTAVPALVHVSNSTGSSVNSEYAGHGEQAQGGAGQGKE
                     TEGGESTSGGSSGKTEDKGKGSEKEKDEDTGAGTGSGTGGSDDPSAAGPADVTPCTADQ
                     LGTSGGTTAAPDSSGTVYGTFRFSNISATDCTVSSPGGVNFITAGAADSTKITTSRHVG
                     GDAAAGLPDPSQELTSLVLKPGAAYEVRFAWIPSETCPTTTDPTEGPDDPTPTPTPTEN
                     PTGTTEGTSTGGDTGTSTQLMSQDTTADGSVTVTNTAEAGAPTATALVSNACAGIIYYT
                     GVLAGA"
     gene            complement(16092..16931)
                     /locus_tag="AQI70_RS08920"
                     /old_locus_tag="AQI70_08905"
     CDS             complement(16092..16931)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999274.1"
                     /locus_tag="AQI70_RS08920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08905"
                     /product="SURF1 family protein"
                     /protein_id="WP_062146190.1"
                     /transl_table=11
                     /translation="MYRFLLTPRWWGINVFVLLAIPFCVFMGSWQLSRFEARVEDHRSA
                     GAQAAENKREAARPLTELLPVDKATVGRQATASGRYGKQLLVPDRELDGKRGYYVLTLL
                     RTDDGKALPVVRGWLPGDADRAEAPAAPTGEVTITGVLQASEMPGENGVPAQGGLPSGQ
                     TAAISAASLVNLVPYDVYDAWVTLNKADSAMKPVPATTPQDTGLDLKAFQNLGYTGEWF
                     VFAGFVVFMWFRLFRREVEFVRDAELGLVPDGAADGGAPQQTGEQPSEGPAQEKANA"
     gene            17044..18882
                     /locus_tag="AQI70_RS08925"
                     /old_locus_tag="AQI70_08910"
     CDS             17044..18882
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999273.1"
                     /locus_tag="AQI70_RS08925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_08910"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_062146192.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.1e-41, bitscore:
                     138.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESHRSDSRDHLKQDKDMPDWEKRFRAPRVSLPDWAEDAPDRSL
                     FVSNATGTYELYAWDRATGEQRQVTDRPNGTTDGLLSPDGEWIWWFDDKDGDEFGVWRR
                     QRFGGGEDELAAPGLDPSYPAGLALGRDGRTAIVGRSTDEDGTTIYLTRTGEPPVELYR
                     HRESAGVGDLSHDGRLIALEHTEHGDAMHSALRVLRPDGTTVAELDDTKGGAVELGLEV
                     LGFAPVDGDTRLLIGHQRRGRWEPLVWDVATGEETDLALELPGDVSAEWYPDGSGLLIV
                     HSFEARSELFRYDLARRELARIPTPAGSVSGATARPDGSVEYLWSSAAEPSAVRSTAGH
                     VVLDPPGMKSPGSVPVEDVWVEGPGGRIHALVQRPAGVEGPLPTVFDIHGGPTWHDSDA
                     FAAGPAAWVDHGYAVVRVNYRGSTGYGRAWTDALKHRVGLIELEDIAAVREWAVTSGLA
                     DPERLVLTGGSWGGYLTLLGLGTQPDAWTLGIAAVPVADYVTAYHDEMEALKAMDRTLL
                     GGTPEEVPERYEASSPLTYVDQVKAPVYISAGVNDPRCPIRQIDNYVKRLEARGAVHEV
                     YRYDAGHGSLVVDERIKQIRLELDFAERHLKAPRRP"
     misc_feature    20124..20143
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.11"
                     /tool="antismash"
ORIGIN
        1 gcacttcacg cccgccgccg gcttcggcta cgagggcaac acgctgcgca tcccgcgcgt
       61 cccgctcaac cggggcgacc acttcaagct gctggtgctg ctgtcgggcg gtgacgtggg
      121 ctgtccgata cggctgcggg gcggcatccg ggacggcgcg gtgcatccca accgcagtgc
      181 gacgccggac gacaagccgc cgctgttcag ccgtgccgcc cggctgatca ccctcatgct
      241 cacggtcagc gtggtgacgc tggcgacgat cgtcgtggcc caggacgaac accgcccgcc
      301 gatcggctgc gcgagcggca ccctgacgat caccggctcg acggccttcg cgccggtgct
      361 gcgggaggtg gcgaagaagt acgagcagga gtgcgccgac ggcggcgacg gggtcacgat
      421 cgaggtggac gcgcacggct cgacggcggg tctgcgggaa ctcgcggcgg ccggcgcgca
      481 ggcggagcgg gcggacaagg gctcaccgcc ggtggtggcc ctgtcggacg gccccaagcc
      541 gagcggtctg ccgcagctgc gggagaaccg ggtggcggtc tcggtcttcg cgctcgtggt
      601 gaacgacgac gtacgcctga cgaacctgtc cacggcagac gtacaacggc tgtaccgggg
      661 cgagatcgcg aactggcgcc ggctgggcgg ccccaacctg ccggtgcacc tcgtcagccg
      721 ggacgccaac tcgggaacga gacaggtgtt tcagcgccgg gtgctggggc ggggcgagat
      781 cgcgaactcg tccgtcgact gcgtgcacaa ggacgatgtg acggcgccgg tcatccgctg
      841 tgaactcgac tcgacggacc aggtgctggc aacggtggcc gacctccccg gcgcgatcgg
      901 ctacagcgag ctcaacgcgg cgacgaacgc caagggcctg cacctgctga ggctcgacga
      961 cgacacgccg tccgtcgacg ccatcgagca gggcgagagc gcctacccgt accgcgagat
     1021 cgagtacgcg tacacctacg gccagcctcc ggccgactcc ctggcgtcga gcttcctgac
     1081 gtacctgtcc cggggcaacg gccaggacgt gatccgcacc cacgggcacc tgccctgctg
     1141 gacaccgggg ggcctgaggc tgtgcgccgc cggtgccggc aatcggcggc cacttcccgg
     1201 cgctgggtcg gcatcatcca gcccgtccgg cgtctgagga cgatggcggt cacttctcgg
     1261 cgctggtcca ggcgatctca gcccgtccgg cgtttgagga cgaggcccgt tcagggccga
     1321 agcgggggtc tgggggccgc aggcccccag ggccggggtc gaaggggcgg agcccctgga
     1381 ggatgggacg ggtaggggcg gcgggggcga aaatcctccc ggccccgtca ccgcggctcg
     1441 ggcggccgct gccgaggcat gttcggccgc gcaccgttcg ccggcggcac ggagaaccgc
     1501 ccctgtccca cccccacgtc ctgccgagcc ccaccggcca cggccgactg gatccccagc
     1561 ggcgcggacc ccgtccggaa ctccaccatc cagtccgccg tctccgcccg caccagctcg
     1621 gtcacatcct cggtgaaccg ccgcaacacc cccagacacc gctccgccgc ctcactcgcc
     1681 gtcccctcgg ccggccccag aatctcccgc acgcactccg tcgcccagtc gaactgcaac
     1741 gcctgcagcc gccgctgcac cgcctgcgcc gtggcgacgt cccttatcca cccggacgtc
     1801 accccgaaga accggtcgat cgccacacac gccaccgcca gcagcagcgc cagatatccc
     1861 cacggcgcca ccccgctcgc gacccccgtc atatcgagca gaggcaacgc ggcccccacg
     1921 atcgcccccg ccgcggcccc gccccgcagc gcccgggcgg cccgccgctt ccacacccgg
     1981 tccgcgagat accacgcggc cgtgttcagc gccccccgct ccacccaccg gtagagctcg
     2041 tccagccgca ccgccggctc cccccagtcc ccgagcggaa acgcccgccc catcagatca
     2101 cccggccgca gtccggccgc cccttcgccg ccccgcccgt cctgtggcga cctctcgggc
     2161 tgcatctccg gctgacccac ccggcactcc ctactgatca cggtgcgtga caccacgtac
     2221 accacgtacg acccgggtaa gacccccaca gcgcacgcaa cgtcacacaa cacctgaggc
     2281 tgacgcgccg gacccttcct accgcccaat gggtggcgaa gagatgcctt tcgcctcttt
     2341 tccgcccgga aggggggtct tgatcaggta taggacagca gttcctctca ctcgaaagag
     2401 tgccggggcg acggctgcgc ggaccacgta ggctcgtgct gaacgggaaa gccgagcgga
     2461 aaccccgtac agacacccgt gcagacacgc gtacacacgc aaggagctga tcgtgatccc
     2521 cggtggtggc cagcccaaca tgcagcagct gctccagcag gcccagaaga tgcagcagga
     2581 cctgcagcgg gcacaggagg aactggcgcg gaccgaggtc gagggtcagg ccggcggcgg
     2641 cctggtgaag gcgaccgtga cgggcgccgg cgagctccgg gccctgcaga tcgaccccaa
     2701 ggcggtggac ccggaggaca ccgagaccct cgccgacctg atcatcgcgg ccgttcaggc
     2761 ggccaacgag aacgcgcaga acctccagca gcagaagctg ggcccgctgg cccagggcct
     2821 gggcggcggc agcggcatcc cgggcctgcc gttctgacgt tccggcgttc tccggcttgc
     2881 ctttctaaga cgggccgcgg ccaactaccg tacgtaccgt aaggaacccc aggaaggacg
     2941 gcagtccgtt gtacgaaggc gtggtccagg acctcatcga cgagctggga cggctgcccg
     3001 gcgtcggtcc caagagcgcc cagcggatcg ccttccacat cctccaggcg gaaccgacgg
     3061 acgtacgccg cctcgcgcag gccctgatgg aggtcaaggc gaaggtccgc ttctgcgcga
     3121 cgtgcgggaa cgtcgcgcag gaggagctgt gcaacatctg ccgggacacg cgccgcgacc
     3181 cggcggtcat ctgcgtggtc gaggagccga aggacgtcgt cgcgatcgag cggacccggg
     3241 agttccgtgg ccgctaccac gtcctcggcg gcgcgatcag cccgatcgag ggcgtcggtc
     3301 cggacgacct gcggatacga gaacttctcg cgaggctggc cgacgggacg gtcacggagc
     3361 tgatcctggc cacggacccg aatctcgagg gcgaggccac ggccacgtac ctcgcacgca
     3421 tgatcaagcc catgggcctg aaggtcaccc gcctggccag cggcctcccg gtgggtggcg
     3481 acctggaata cgcggacgag gtcaccctcg gccgcgcctt cgaggggaga cgactcctag
     3541 atgtctgacg ccacgctgca cgcgaccgag cagaacccgg acgacttcgc ggtccagatc
     3601 gcggaccaga tcgagagctt cctggtcgcc gtcacggagg tcgcgaaggg cgacgagccg
     3661 ggctcgaccg tgcccttcct cctgctggag gtctcccagc tcctcctggc cggcggccgc
     3721 ctcggcgccc acgaggacat cgtccccgac gagcgctacg agcccgacct gggcccggag
     3781 ccggacgtcg acgaactccg cgagaacctc gcccgcctcc ttgacccggt cgacgtctac
     3841 tcggaggtct tcgaccccta cgagccccgc aaggccccgg tcccggcccg gatctccgac
     3901 gacctggccg acgtcatcac cgacctccgc cacggcatgg cccactaccg cgccggccgc
     3961 accacggagg ccctgtggtg gtggcagttc tcgtacttct ccaactgggg ctcgacggcc
     4021 tccgcgaccc tgcgcgccct gcactcggtc ctggcccacg tccgcctgaa ccagcccctg
     4081 gaggaactgg acggcctgga cacggaccag ggcgtgatgg gcgacgagac cctcgaattc
     4141 gaggccggca aggtgatgga gcaggagatc ggcgagcagc tggggctgcg gccggcgcag
     4201 taggaggcgg gcggcgcggc gcttcctgcg gtggtgtgac gcgggttaca gcaaaaggct
     4261 tctgaagcgg cgtaatgcac gggcccctcg ggcggtctca caggcaccgg cacaacggcc
     4321 acccccggcc ggtgcccccg cccccgaatc ggagcccgac catgcacgtc accctggagc
     4381 agccgaccgg cgcccgcctg atcaccgccg cggaccaggc catcgcgata cccgccaccc
     4441 tccgctacac ctccgccgac ccgctggccg tacacctcga cttcccgccc catgtcaccg
     4501 tcgacggcga ggtcacgacc tggacgttcg cccgcacgct cctggccgag ggcctgcgcg
     4561 ccccggccgg gcccggcagc gtacgggtcc gcccgtgcgg ggcgtcccac acctacgtgg
     4621 agttccactc cccggcgggc acggccgtgc tccgcttcac cacctcggac ctgtaccgct
     4681 tcctggcccg cacgtacacc gtgatcgcgc cgggggagga gaccgtgggg gcggagctgg
     4741 accaggggct ggcggcgctg ttcggcggac gggtgtaacc gggatcctcc aaggtggtcg
     4801 cagggcgact cggtcaacgg cgttggtggg gacgggaatc ggactctgcg tgaccggggc
     4861 tctggggttg gtcgtgggcg gcgtgctgga cgtcggcgcc gcggatccct gggcgagcgt
     4921 ggccggggga gcggcggggc tgatcggact ggcggtgacg ctgtacgcct tcctcggacc
     4981 ggcgcccacg gccgccgccg tgaccgcgag cggtacgcgt gcggttgccg cgggcggcag
     5041 catcggcgcg gtgtcgacgg gggacgggac gtcgaccacg ccaccgccgc ccacgacgcc
     5101 cggctcgccc acgcggccgg cgagcgggcc cgtcaccgcc tccggggagc gttccgtcgc
     5161 ggccggcggg gacatcggtt cggtgtcggc aggtgacggg tgacgggtga cgggtgaggg
     5221 gtgacgggtg agcgggtctg tggcggcact caaggaattc gtggactgat cacagccccc
     5281 acaggccctt ccccacggcc gtcaccccgc ccgtcagggc cagcagcagg acgagcaggc
     5341 gggcccgccc ctccggtatc cgggaagcga gccctctgcc gatgagcccg cctgccccca
     5401 tcgccgcggc caccagaacc cactgcgccc cgctcagccc cggcaccccg ttcgacgcca
     5461 cggagaacgc gttcacgacc acgccgtaga acatcgcgtt cggcacgaac tcccgtaccg
     5521 tccaccccgc gttgaccgcg tacagggaca ccggcggacc gcccaccccc gccgcggagt
     5581 tcatgaaacc gcccaccgcc ccggccgcga ccgcgccctt cgcgccccgg agggcgggga
     5641 cgcgggctcc ccgcatgatc agcagcacgg cgagcgtcac caggccgccc atggtcaaca
     5701 acaggaccgg ctcggggagt tggcgagtca gccaggtccc cgccggcacc gtgcacgccg
     5761 ccgccgcgca cagcggcacc atcgcgccca tccgcacccg gcgccagcca cccgcgagcc
     5821 ccacgacact gatcaccccg gccgcgcagt tggccaggac caccccttgc gtcggtccca
     5881 gcagcaggac aagggccggt acggcgacca gtgcgaagcc catccccgtg agccactgca
     5941 cgctggagcc gagcaggacg accccggcca gcagtatgtc tcccgcccac tcacccgtca
     6001 caggtcggta tccttccgcc gccgacagcg cgtgatcaat gactgcaagg cgcgaattgg
     6061 acgagccctt tcccggggct gtacgtcgcc tgcacgggcc ctaaccagtg ccacgcgaat
     6121 ctggagtcac ctccaccgca cagaacgcgg agggaggaga aacaccaggt caacccccct
     6181 gcactggaga tgcgatgacc cgtcgttccg taagcaagcg cgtagccgtc gtcaccgcca
     6241 ccgccgtcgt cgccgtcggt accttcgccg ccggagtcgg tgtcgccggt accggagggg
     6301 atgacaaggc ggcgagcaag aagcagatag ccgggctgtt cgaccagtgg aacagcacgc
     6361 tgcagaccgg cgacccgaag aaggtcgcgg acctgtatgc gagcgacgcg gtgctcctgc
     6421 ccaccgtgtc caacaaggtc cgctccgacc gcgccgccat cgtcgactac ttcgagcact
     6481 tcctggcgaa caagccggtc ggcaagaaga tcgagacgca cgtcaacgtc ctcgacggga
     6541 actccgcgat cgacgcgggt gtctaccagt tcacgctcac cgacaaggcg accggtgaga
     6601 agagcgtcgt caaggcccgc tacacgtacg cgtacgagaa gcggaacggc gagtggaaga
     6661 tcgtcaacca ccactcctcg aagctgcccg aaggctgatc gtcaccttca gcccgccccc
     6721 gggcgcgtcg gtcagcgtca cggtcccgcc gtcgtccgtc accagctgtt tgacgacggc
     6781 gaggccgagg cccgagccgg acttcccggt caggccctgg ccgcgccaga agcggtcgaa
     6841 ggcgcgggac ttctcggcgt ccgacatgcc ggggccctcg tccaggatcg acacatccac
     6901 cacctcgccc cggggctcca cccggacggt gatcgtcccg ccgtccggtg agacctccag
     6961 ggcgttggag agcacgttgt ccagtacctg gtccagagca ccagggctgg ccagcacaga
     7021 cggccggccg tcggcactcc ccctgagcgc gatggtgact ccgcgctcgt cggcggccgg
     7081 cctccacacc gcgagccgtt cccgcacgat gtccatcagc gggagcggct cggcggccgt
     7141 caccttggcc tcggcccggg cgagcaccag caggccgttg accaggcggc tcatccggac
     7201 cacctcggcg gtggcctgct ccacgtcctc gcgtacgaac tcgtcgtcca ctccgtccgc
     7261 gatgttgtcc agggacaggc gcaacgccgt gaggggggtc cggagttggt gcgaggcgtc
     7321 ggccacgaag atccgctgcg aggcgacgag cgtgtcgagg cgttccgcgc cctggttcag
     7381 ggtgcgggcg agcgtctggg tctccggcgg gcccgtgacc ggggagcgcg cggtcaggtc
     7441 gccgtcgctg aacttgctcg ccatggagtt cagttcgcgc agcggcgcgg tgatgcggcg
     7501 ggcgacgaac gcgccgatcg cggcggccgc ggccagcacg agcagggcca gtgccgcccg
     7561 gaagccccag atctgccaca gccgcgtggt catgtccgag gtcgagtaca cgatccgcac
     7621 ggccgcatcc ccctgggcgg ggacggggac ggtgatcgtc aggtgcttgc cccagatgaa
     7681 gtcggagccc cagtcggtcg tcggctcgtt ccgctccacg gcccgggtca gcgccgcgtc
     7741 cgccgcgggc ttgggcaggt ccggagcgca gctgctggtg ggagtcacct ggacgttgcc
     7801 gggtgtctcg gcgccgtacg ccttggccac cttcgtcagg gcgtcgcacg aggtggtgtc
     7861 gctgttgccc agcagcagcg ccatggtctt ggcctcgcgc aggacggaca gctcggtgtc
     7921 gtcccgcagc tgcttggtga gcgtgaaggc caccggcacg gtgaacagga agatggcgac
     7981 cgcgacgagc aggatgtagc tgcggatgag ctggcggttc atgaggcgtc gctgccctcg
     8041 ccgtcgccgc ccttcgcgtc ccggacgatc tccagccgga acccgacccc ccgaaccgcc
     8101 tcgatcgtga tcgcccccgc cagcttccgc cgcagcgccg ccacatgcac gtccagcgtc
     8161 ttcgtcgggc cgaaccagtt ggcgtcccag accgcctcca tgatctgctc gcgcgacatc
     8221 agcgccccgg gctcctcggt gaggaaggcc agcaggtcgt actccttggg cgcgagggac
     8281 acctcctcgc cgtccaggcg gacccgggcc gccttgcggt cgatggtcag gcgggggccg
     8341 tagcggtccg ggccggcctc ggcggcggca gcgggcgtac ggggctgcag gcggcgcatc
     8401 accgctcgta tccgcgcgat gacctcgcgg acgccgaacg gcttggacac gtagtcgtcc
     8461 gcaccgagct ccagcccgac cacccggtcc gtctcgtcgc tgcgcgcgct gatcacgatg
     8521 atcggcacgt cgccgcgttc gcgcagcgcc ttgcagacgt cgaggccgtc ggtgtcgggc
     8581 aggccgagat cgaggaggac gacgtcgtag ggggcgtcgt ggctcagcgc cgcggcaccc
     8641 gtggtgaccc atgccacctc gaagccgtag cgcagcaggc cgcgccgaag cgactcggcg
     8701 accggttcgt cgtcttccac cagcagtacg cgcacatgcg caccatagtg gttgaacttt
     8761 aaagacgtcc ggtcgccgat cctgatagcg gtcaatggct ggacataatg ggttaaacct
     8821 cggctaccac atcaccggca gccgctccgg gatccgcttc atgaacccgg tccgccacac
     8881 cagctgctcg atcggcaccg ccagccgcag cccgggcatc cgctccagca gggtgtccag
     8941 ggcgatctcg gcgtgcttgc ggccgagcgc ggtggcgggg cagtagtggc ggcccccgcc
     9001 gaaggacaga tgggcggtgg cgttctcgcg gccgaggtcg accgtgtgcg ggtcggggaa
     9061 ggcggccggg tcgaagttgg cgccctcgac gaggaccagg acgaggtcgc ccgcccgcac
     9121 ctccacgtcg cccagccgta cgtcctcggt cgccagcctc ggcaggccgt cgccgatgga
     9181 caggttgatc cgcagcagct cgtccacggc cgcggggacc agggtgcggt cggcgaggag
     9241 gcgggcgtgc agctcggggt gctggatcag cgacaccagg gccatggcca ggaagcccga
     9301 ggtggagatg acgcccgcgc cgaacatcgt caccccgacc gtggcgagca tctcgtcggt
     9361 gagatgggcg tagtcggggt ccgcgcgcag ggcggcgagc tctcccatca ggcccatcgt
     9421 cgccgggtcg tcgagccgct cggtcatgta cgcgatgtcc cggtcccagt tcagccgggc
     9481 gcccgcgatc gggcaggccg agttcatgaa cgcgatgtcc agactccgca tcagccgggg
     9541 cgcgtccgcc agcgggatgc cgaggatgcg gcagtgcatg cccgccgagt acgggtcggc
     9601 gaagccgccc cgcagatcca ccggcgcgcc ctcgcggacc agcccgtcga cgagctcggc
     9661 ggcgtacgac cgcatccact ccgccagacc ggggctcttc ggattgagcg ccttcagtac
     9721 ggccttgcgc agcccggcgc cggtgatgtt ccccatgttg ttgacgacct cgggcgggat
     9781 cgtcagcgcg tactggcggg gcacgcccgg cgccgaggtg tccttcaggc tgaagcgcgg
     9841 gtcttcgagg acctgcttgc acagctcgta cgacgacacg agccaggcct cgtcaccggc
     9901 gatggtgcgc acccggcgca cgggtgcgtt ggcgcgcaac tcctccacct cggcggggat
     9961 ttgatcgccg cgccaggaga acgggaagtc gatgagggct tcagtctgca tcggtggtcc
    10021 cctcggccgg agtgacgatg gcgtggccct ggttgcggga ggcgcgcagg ccggcgccgc
    10081 gggcgtagag cagctcggcc atcggcagca gctggtggta gcagttgagg gaggagggga
    10141 cgtcgaggat ggcgggggtg tccaggaaga ggggtgcctc ggcgcagacg taggcgaggc
    10201 agacctcgcg ctgggcgtcg gtcgcgcgcc ccgcccggcc ggccaggaag gagtccacga
    10261 gtttctcgca ggtcgcgtgg aacgcgccgt cggtggcgag ccgggcctgg aggtggtcgt
    10321 ggatctcgcg gtacgccggg ttgccgtgga agtcggacat ggcgtgggcg cgcagccgcg
    10381 tgccgtcggg gtccaccgcc tggacggcgc ccagcacctt ggcgcgcacg ccgcgcaggt
    10441 tcttcaccgc cttgcggcgc gcgtcgtcgg gcggatagcc ggacgccgcg tacatctcgg
    10501 ccacgtacag gtcggtgtag acgaagtcca cccgctcgaa cagggcgagg ccccagcggg
    10561 cgaggtcgtg gacgcggcgg gcggagaaat agctgttgcc cggggagacc ccgatgacgg
    10621 cgtggtcgcc ggcggcgcgg atgacctcgc agtgcggagt gaagggctgg acatcgaaga
    10681 ggccggccgg agaatcggcc tcggtatcgg cccgggtgac gtgctggatc tctggaacgg
    10741 tcacagtcgt caaaggagga gagtccttcg cgtcgctagt cccgatggag ccttgtgctc
    10801 ctggtgtggc gacgacgacg cgaagttagc ggtcgactac gcagagcgtc aatggcggag
    10861 ccgggcggtc ccgtgcgcgg tcctcaccag ggcggtcgtc agacgacggg ggagaggacg
    10921 ttcgggagcc gaaggaggtc cgcgccatcg gcgcccacgt ggatggcgcc gttcgcggcc
    10981 gtgtagagcg tccctcccag aaggtcgacg tgaatttcag cgtgggccgg ggccgccggc
    11041 gtcgccgcgc ccgcagtgag ctcgcccgac aagcacgcgg ccgtgggggg tgcggtggtg
    11101 aagaggtccc agtcggaggc aggggcgccc ggcgcacgct ctcgcatgcc ggggtgcggg
    11161 ccccagtgac ctgcaccact tccccgtatg cactgccgtc caccgggcag ggaccacccc
    11221 gagcgaacga atctcaccat ctgggaaccc caaggtcgtt ttcgggcgct cgttagactg
    11281 agccgacaca cacggactga gcgaggagcg cacgtgggcc ttgtcgtgca gaagtacgga
    11341 ggctcctccg tagccgatgc cgaaggcatc aagcgcgtcg ccaagcggat cgtggaagcc
    11401 aagaagaacg gccaccaggt ggtcgccgtg gtttccgcga tgggcgacac gacggacgag
    11461 ctgatcgatc tcgccgagca ggtatccccg atgcctgccg ggcgcgagct cgacatgctg
    11521 ctgaccgccg gagagcggat ctccatggcc ctgctggcca tggcgatcaa aaacctgggc
    11581 cacagcgccc agtcgttcac cggctcccag gcaggtgtca tcaccgactc ggtccacaac
    11641 aaagcccgga tcatcgatgt gacgccgggc cggatccgtg actcgctgga cgagggcaac
    11701 atcgccatcg tcgccgggtt ccagggtgtg agccaggact ccaaggacat caccacgctg
    11761 gggcgtggcg ggtcggacac caccgctgtc gcgctggccg ccgccctcga cgccgaggtg
    11821 tgcgagatct acaccgacgt cgacggcgtg ttcaccgccg acccgcgcgt ggtgaagaag
    11881 gcgaagaaga tcgactggat ctccttcgag gacatgctgg agctggccag ctccggctcg
    11941 aaggtgctgc tccaccgctg tgtggagtac gcccgccgct acaacatccc gatccatgtc
    12001 cggtccagct tcagcgggct tcagggcacg tgggtcagca gcgagccact cgttcgaaag
    12061 acgcagcagc aaggggacaa gcaggtggag caggccatca tctccggtgt cgcgcacgac
    12121 acctccgagg ccaagatcac cgtcgtcggt gtgccggaca agccgggcga ggccgccgcg
    12181 atcttccgca cgatctccga cgccgagatc aacatcgaca tgatcgtgca gaacgtgtcc
    12241 gccgcctcca ccgggctgac ggacatctcc ttcacgctcc ccaaggccga gggccgcaag
    12301 gccatcgacg ccctggagaa gaacaagagc ggcatcggct tcgactcgct gcgctacgac
    12361 gaccagatcg ggaagatctc gctggtcggc gccggtatga agaccaaccc gggtgtcacg
    12421 gccgacttct tcacggccct gtccgacgcg ggcgtgaaca tcgagctgat ctcgacctcc
    12481 gagatccgca tctcggtcgt cacccgcgcc gacgacgtca acgaggccgt gcgcgccgtg
    12541 cacaccgcct tcggtctcga ctccgacagc gacgaggctg tcgtgtacgg aggcaccggg
    12601 cgatgactcg tcgaccgacg ctcgcggtcg tgggagcgac cggagccgtc ggcacggtca
    12661 tgctccagat cctgtcccag cgcgcggaca tctggggcga gatccgtctg atcgcctcac
    12721 cgcgctcggc cggccgcaag ctggccgtgc gcggcgagga ggacgaggtg gtggcgctca
    12781 ccgaggaggc cttcgccggg gtcgacatcg cgatgttcga cgtaccggac gacgtggccg
    12841 cccgctgggc gccgatcgcc gccgccaagg gcgcggtggt ggtggacaat tcgggcgcct
    12901 tccggatgga cccggatgtg cccctggtcg tccccgaggt caatccgcac gcggtgcgga
    12961 tgcggccgcg cgggatcgtc gccaacccca actgcacgac cctgtccatg atcgtggccc
    13021 tgggcgcgct gcacgccgag ttcgggctgc gcgagctggt ggtgtcctcg taccaggcgg
    13081 tgagtggcgc cggacgcgcc ggggtcgaga cgctccggca gcagctgtcc ctggtcgccg
    13141 gtacggacct ggggaccagc cccggggacg tacggcgggc catcggcgag aacaccgggc
    13201 cgttcccgga gccggtcgcg ctcaacgtcg tgccgtgggc cgggtcgctg cgtgcggacg
    13261 gctggtcgtc ggaggagatg aaggtgcggg gcgagtcccg caagatcctc gggctgccgc
    13321 agctgccggt cgcggtgacc tgtgtgcggg tgccggtgct gaccgggcac tcgctgaccg
    13381 tgcacgcccg cttcgagggt gaggtcacgg tcgccaaggc gcgcgagatc ctggccacgg
    13441 cgccgggggt cgtgctgtac gacgacccgg aggcgggcga gttcccgacg cccgccgatg
    13501 tggtgggcac ggatccgacc tgggtcgggc gggtgcggcg cgcgctcgac gatccgacgg
    13561 cgctcgaact cttcgtgtgc ggggacaatc tacgcaaggg cgcggcgctc aacaccgcgc
    13621 agatcgcgga gctcgtggcg gcggagttcc tgtgagaccc cccgcggtgc cggaaaacac
    13681 ctgggccctg tccgaatcgt ttgtaggatc tgtgggacca gtgtgagccg aacgatggtc
    13741 cggaccactt gaaccgggtc cggcggcagc cgaagatttt ctccccgccc tctgcaaccg
    13801 cttgcagggc ggggagcgtc tttgcggtcg cccttatggg gcgggaagac gcgttttttt
    13861 ctggcgtggg gacgccatgg gcagggcgtg gggacgcccg ttcatatggg acataaggga
    13921 agagcgggta ggcatgtggg cgtttgacgc actgtcggct gtgctgcctg gcacgagagg
    13981 gtcggctgct gggactggcg caaaagtgac gtccggcacg tacaaccctc caggggggac
    14041 gcgtgtccaa caggcgtggc agaggtactc gacttcagcg cggcgacccg cggcacggcc
    14101 ctacggccgc cccgccggcc cgttcgatca cgcatgcccg gcgcgcccgg cggcatgccg
    14161 gtgatcgcgc ccatgcccgc agcgcggccc gcccgcattc ccagtcagcg tgacggtgcc
    14221 gacgccgaga gcaccgcggc ggccggtacg accgtcgatc acctcaccga gacctaccgg
    14281 gcccactacc gctcgctgct gggtctcgca gccctcctcc tcgacgacac cgcctcctgc
    14341 gaggacgtcg tccaggaagc gttcatccgc gtccactccg cgcgcaagcg cgtccgtgac
    14401 ccggagaaga cgctggcgta tctgcgccag accgtcgtca acctgtcccg ctccgccctg
    14461 cgccgccgga tactgggtct gaagctgctg tccaagccga tgcccgacat ggcgagcgcg
    14521 gaggaggggg cgtacgacca gctggagcgc gactcgctga tccgggcgat gaagggcctg
    14581 cagcgccggc agcgcgaggt gctggtcctc aggtatttcg cggacatgac ggaggctcag
    14641 gtcgccgaga cgctcggcat ctcgctgggc tccgtgaagg cgtacggctc gcgcggcatc
    14701 gcggcgctgc gggtcgccat ggaggcgccg gcatgagcga ggaccatgag gggcggcgtc
    14761 agctgcacgt cccccacgag ccctatgaat ggcgagagcc gacggggcgt ccggacaagc
    14821 aagagccgaa gcaatcgcac gctgggaacg gaactgtgaa ccacggcccc gacgaccagg
    14881 gccccgaggg gctcgactcg gacgagctgg cactgcgccg catactgcac caggcggtcg
    14941 aggagatcga accgcgtgac ggcacgctgg accatctgcg gcgggcggtg cccgcacggc
    15001 gggcgcgcaa gcggcaggcg ctcgtcggcg cggcggccgc ggtgctgttc ctcggcaccg
    15061 ccgttccggc cctggtgcac gtctccaact ccaccggctc cagcgtcaac tccgagtacg
    15121 ccggccacgg cgagcaggcg cagggcgggg ccggtcaggg caaggagacc gagggcggcg
    15181 agagcacgtc cggcggttcc tcgggcaaga ccgaggacaa gggcaagggc agcgagaagg
    15241 agaaggacga ggacaccggc gccggtaccg gcagcggcac cggaggttcc gacgacccct
    15301 cggcggccgg cccggcagac gtcaccccgt gcaccgccga ccagctcggc acgtcaggcg
    15361 ggaccaccgc cgcccccgac tcgtccggca cggtgtacgg caccttccgc ttcagcaaca
    15421 tctccgccac cgactgcacg gtgagcagcc ccggcggggt gaacttcatc acagcgggag
    15481 cggcggactc caccaagatc accacgtccc gccatgtcgg cggcgacgcg gcggccggtc
    15541 tgcccgatcc ctcccaggaa ctcacctcgc tcgtcctcaa gccgggcgcc gcgtacgagg
    15601 tgaggttcgc ctggatcccc tcggagacct gccccacgac gaccgacccc accgagggcc
    15661 ccgacgaccc cacacccacc ccgaccccga ccgagaaccc caccggcact acggagggca
    15721 cgtccacggg cggtgacaca ggcacctcca cccagctgat gtcgcaggac accacggcgg
    15781 acggaagcgt cacggtcacc aacacggcgg aggcgggagc cccgacggcc acggcgttgg
    15841 tgtccaacgc gtgcgcgggg atcatctact acacgggcgt gctggccggg gcgtagcagc
    15901 ggggcttgac ggtcgttccc atgcgcgaca cagcgtggcc ggccctcacg ggcccggccg
    15961 gggcggggga gcgcactcgg ccgggagagc gcgggccgag cggtacggcg ctgagcaccc
    16021 cggcaccgtg ccggcgccgg gcacacgggc cccggcagcc gcaggcaccg ggcgccgcgc
    16081 aaacctccgc tctaggcgtt cgccttctcc tgtgccggtc cctcgctcgg ctgctccccg
    16141 gtctgctgtg gggcgccccc gtcggccgct ccgtccggta ccaggcccag ctcggcgtcc
    16201 cggacgaact ccacctcgcg gcggaacagg cggaaccaca tgaagaccac gaagcccgcg
    16261 aagacgaacc actcgccggt gtagccgagg ttctggaacg ccttcaggtc gaggccggtg
    16321 tcctggggag tggtcgccgg gacgggcttc atggcggagt cggccttgtt gagggtgacc
    16381 caggcgtcgt agacgtcgta cggcacgagg ttcaccagcg acgccgcgct gatcgccgcg
    16441 gtctgcccgg acggcaggcc gccctgcgcg ggcacgccgt tctcgccggg catctcggac
    16501 gcctggagca cgccggtgat cgtgacctcg ccggtgggcg cggcgggggc ctcggcccgg
    16561 tcggcgtcgc cggggagcca gccgcgtacg accggcaggg ccttgccgtc gtcggtgcgc
    16621 agcagcgtca ggacgtagta gccccgcttg ccgtccagct cccggtccgg caccagcagc
    16681 tgcttgccgt accgcccgct cgcggtggcc tgcctgccca ccgtcgcctt gtcgacgggc
    16741 agcagctcgg tgagcggacg ggccgcctcc cgcttgttct ccgcggcctg cgcaccggcg
    16801 ctgcgatggt cctcgacccg cgcctcgaac cggctcagct gccacgaccc catgaagacg
    16861 cagaagggga tggccagcag cacgaagacg ttgatccccc accaacgggg cgtcagcaga
    16921 aaccggtaca cgccttcaac ggtacggggc tcctgcggag ggccgggccg cggggtcccg
    16981 aagttatcca caggctgggg acctggccag cgaattgtcg gccgggccag gcactatggg
    17041 gccatgactg agagccacag gtccgattcg cgggatcacc tcaagcagga caaggacatg
    17101 ccggactggg agaagcgctt ccgggcgcct cgggtgtcgc tgcccgactg ggcggaggac
    17161 gcaccggacc gctccttgtt cgtgtcgaac gccacaggga cgtacgagct gtacgcctgg
    17221 gaccgcgcga cgggcgagca gcgccaggtg accgaccggc cgaacggcac gacggacggc
    17281 ttgctctccc cggacggcga gtggatctgg tggttcgacg acaaggacgg cgacgagttc
    17341 ggcgtctggc gccggcagcg gttcggcggc ggcgaggacg agctcgcggc gccgggcctg
    17401 gacccgtcgt acccggcggg cctcgccctc ggccgggacg gccgtacggc gatcgtgggc
    17461 cgctccacgg acgaggacgg caccacgatc tacctgaccc gcaccggcga gcccccggtg
    17521 gagctctacc gccaccggga gtccgcgggc gtcggcgacc tctcgcacga cggcagactg
    17581 atcgccctcg aacacaccga gcacggcgac gcgatgcact cggccctgcg cgtcctgcgc
    17641 cccgacggca cgacggtcgc cgaactcgac gacaccaagg gcggcgccgt ggagctgggc
    17701 ctggaggtcc tgggcttcgc gccggtcgac ggcgacacgc gcctgctcat cggccaccag
    17761 cgccggggcc gctgggagcc gctggtgtgg gacgtggcga cgggggagga gacggacctc
    17821 gcgctggagc tgccgggcga cgtgagcgcc gagtggtatc ccgacgggag cggtctgctg
    17881 atcgtgcaca gcttcgaggc gcgcagcgag ctgttccggt acgacctggc ccggcgtgag
    17941 ctggcgcgga tcccgacccc ggcgggctcg gtgtcggggg cgacggcccg tccggacggc
    18001 agcgtggagt acctgtggtc gtcggcggcg gagccgtccg cggtccggtc gacggcgggg
    18061 catgtggtgc tggacccgcc cggcatgaag tccccgggct cggtgccggt ggaggacgtg
    18121 tgggtggagg gccccggcgg ccgcatccac gcgctcgtgc agcggccggc gggcgtcgag
    18181 ggcccgctcc cgaccgtgtt cgacatccac ggcggtccga cctggcacga cagtgacgcg
    18241 ttcgcggccg ggccggcggc ctgggtggac cacgggtacg cggtcgtccg cgtcaactac
    18301 cgcggctcca cgggctacgg ccgcgcctgg accgacgccc tcaagcaccg ggtcggcctg
    18361 atcgagctgg aggacatcgc ggcggtccgg gaatgggcgg tgacgtcggg cctcgccgac
    18421 cccgagcgtc tggtcctgac cggcggctcc tggggcggct acctcaccct gctcggtctc
    18481 ggcacccagc cggacgcgtg gacgctgggc atcgcggcgg tcccggtcgc cgactacgtc
    18541 acggcgtacc acgacgagat ggaagcgctg aaggccatgg accgcaccct gctgggcggc
    18601 acaccggagg aggtgccgga gcgctacgag gcgtcctcac cgctgacgta cgtcgaccag
    18661 gtgaaggcac cggtctacat ctcggcgggc gtgaacgacc cacgctgccc catccggcag
    18721 atcgacaact atgtgaagcg gctggaggcc cggggcgcgg tgcacgaggt gtaccggtac
    18781 gacgccgggc acgggtcgct ggtggtcgac gagcggatca agcagatcag gctggaactg
    18841 gacttcgccg agaggcactt gaaggcgccg cggcgcccgt gacgccacgg gggtgagggg
    18901 gcggagtcct ttcggctcac gccccggccc ctcacgtccc cggccgctca cgcccccggc
    18961 cgctcacgtc tccgcccgct cacgtccccg cccgctcccg cgaccgcctc cccagcagtt
    19021 ccgccaggcc cctgcgcgta gccgccagca ccacccggtc gtccttctgg aggacatagg
    19081 tgtcgggcag gtcccacacc caccccgacg ccccgcccgc ccggccgtcc tcgtacgcct
    19141 cctccgccgc aggctcctcc cggcgatcgt cgcggcgctc gtcccgtgcg gtcctgtcca
    19201 gggccagcac ccgccaggca cccgcccgga aggcctggcc gacggtcttg tcctccagct
    19261 gtggatggcc ggccacgtcc accgccgcga acagcagcac ccgccgctcg acggggatcg
    19321 cccccaggat ctggcggccc atcatcgccc cggcgaaggc gggcgcggcg agatggctca
    19381 cgctccggct gcgggtggac gcgtgggggt gcgcggcgcg cagggtgcgg tagacggcgg
    19441 tggcgaagtc gtcgtcgtac aggcgcagga ccacccggag gtcggggcgc acggagcgtg
    19501 cgtacagggc ggcctccaga ttcgtggtgt ccgcgctggt caccgcgagc agcgcgtgcg
    19561 cccgatggat cttcgccgcc tccaggacgc cctcctgcgt gacgtccccc agcaccaccg
    19621 gcacccgcag ccgccgggcc gtcgccagtc cccgcgcctc ggggtcggcc tcgacgcaca
    19681 ccacggggat gtgcagttcc cgcagccggg tgagcacccg ggtgccgatc ttgcccaggc
    19741 ccagcagcac cacgtgcccg cccagcccgc gcggtggttt gcgcagcgcg gacgcggagc
    19801 ggaaggtgcc cagggcctcc agcaccgccg ccagcagcac cggaaggagc agcagaccga
    19861 tcagcccgga cagcagctgg aggatctgcc gggccgtcga ctggtggagc gcgggttcgt
    19921 tgatggcgaa gaggtcgagg agggtgatgt acgtcgcgta cagcgggtgt tggccggtca
    19981 ccagggtcag cgccacggcc agcgccgcca cacagcccac cagtcccgcc agcgaccacc
    20041 gcagccgccg ggagaacagc gacgcgaacg acggcaccgc gcctcgcccc gacggcagcg
    20101 agggccccgc gaacgacacc tgctccagga cgaccgtccc gcgccccctg gcctcccgta
    20161 ccgccgccgc gtcgggcagc agcagcggac cctgctcccc gccgccctcc gaaccgtccg
    20221 ctcccgccgg gtcgttgccg gtcgaggaca gcagggccag cgtggccagc ccggaagggg
    20281 gcgcctgacc ggggcgcgcg ggcgggcgct ccaccgcgcg cagcaacaga ccttccgcct
    20341 ggacgacctt ggtggtgccg gcgacggccg cggcggccag cgcgggggcg gccgtatcgg
    20401 cgtcggacag gacggtcgtg gaggcgtcca gcccgatgtc gccgagtccg gtcgccaacg
    20461 tggcggcctg gtcgaggagt tcctcgatgt gctggcccaa ccggcggttg tacaggcgca
    20521 ggacgagccg gaggcggggg ttgaggcggc gggcggtgag ggcgccacgg atgttggtct
    20581 cgtcgtcgtc gtagacgagg gcgagcgcgg cggcctgctc cacgcccgcc tcggcgagct
    20641 tggcctcggt ggcctcggcg gcctccacca cccggatgct cccggccggt tcgccgccgc
    20701 cgacggcctg gccgcccgcg cggcccacgg ccgcggtcac cacg
//
