LOCUS       NZ_LNBE01000004        22862 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_4, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000004
VERSION     NZ_LNBE01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 3642602)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 3642602)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   3  (bases 1 to 3642602)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   4  (bases 1 to 3642602)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   5  (bases 1 to 3642602)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
REFERENCE   6  (bases 1 to 3642602)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 591313
            Orig. end                         :: 614175
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22862
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22862
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22862
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12862](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12862
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(82..95)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    290..305
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.42"
                     /tool="antismash"
     misc_feature    343..356
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.7"
                     /tool="antismash"
     misc_feature    439..452
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.79"
                     /tool="antismash"
     gene            complement(880..1671)
                     /locus_tag="AS857_RS19810"
     CDS             complement(880..1671)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180135.1"
                     /locus_tag="AS857_RS19810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ECF transporter S component"
                     /protein_id="WP_058046918.1"
                     /transl_table=11
                     /translation="MRLGRRSIAALLLVSATGVAAFGWPLLADSASGLAHSQDAPWLFA
                     ALLPLLLAVVVAAIADSGLDAKAIAMLGVLAAAGAALRPLGAGTAGIEPMFFLMVLSGR
                     VLGPGFGFVLGAVSMFASALLTGGVGPWMPFQMLSMGWVAMGAGLLPGPDRLRGPREVL
                     MLAGYGAVASLLYGTVMNLQGWPYIGSLATGVSFVPGDPVEENLARFVAYCLATSLGWD
                     VPRAVVTVTATLTLGPTVLKALRRATRRAAFDAPVTFGEPR"
     gene            complement(1809..>2549)
                     /locus_tag="AS857_RS19815"
                     /pseudo=""
     CDS             complement(1809..>2549)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381130.1"
                     /locus_tag="AS857_RS19815"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GLAVRHGRLVALRDVNLSVRAGETVALMGRNGAGKSTLLRTLVGM
                     HKPAAGSVRVGGAAPQSTTPAELLRHVGLVPQEPRDLLYADTVAAECAAADGDAGAEPG
                     TCRALVSRLLPDVPGTTHPRDLSEGQRLALALAVVLTASPPLILLDEPTRGLDYAAKHR
                     LVEILRGLAAEGHAIVLATHDVELAAELAHRVVVIADGEIVADGPTAEVVVSSPAFAPQ
                     VAKVLAPQPWLTVGQVRDALEAGS"
     gene            2802..>2912
                     /locus_tag="AS857_RS41545"
                     /pseudo=""
     CDS             2802..>2912
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309042.1"
                     /locus_tag="AS857_RS41545"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MerR family DNA-binding transcriptional
                     regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAAETETGEATLTVDELAARAGVTVRTVRFYSTRGLL"
     gene            complement(<3348..4160)
                     /locus_tag="AS857_RS19820"
                     /pseudo=""
     CDS             complement(<3348..4160)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576995.1"
                     /locus_tag="AS857_RS19820"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIRFEQVSVTYDDAEAPSLQEVDLTVPEGELCLLVGPSGVGKSTL
                     LGTVSGLVPHFTGGTLHGRVTVAGRDTRTHKPRELADVVGTVGQDPLAHFVTDTVEDEL
                     AYGMESLGIPPHTMRRRVEETLDLLGLATLRDRPIATLSGGQQQRVAIGSVLTTHPKVL
                     VLDEPTSALDPGAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADRVILLPGPGQAP
                     VMGEPAEVMAVSPVHPPVVDLGRLAGWSPLPLSVRDARRMAPALRERLA"
     gene            complement(<4484..>5734)
                     /locus_tag="AS857_RS19825"
                     /pseudo=""
     CDS             complement(<4484..5734)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892284.1"
                     /locus_tag="AS857_RS19825"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRPGRRGLLAGPPTPRMSDRKKPPRGGAGVGARAGARASAGAGV
                     SAGAGGGAEAGVGGAPLTSRASALHAGAWWVWALGLAAAASRTTNVLLLGLLIAVAGYV
                     VAARRTDAPWARSYGAFLKLGLAVIGIRLVFAIVLGSPIPGTHTLFVLPEVPLPDWARG
                     VRLGGRVTAEGLLFAFYDGMKLATLLVCVGAANALASPARLLKSLPGALYEAGVAVVVA
                     MTFAPNLVADVQRLRAARRLRGRPDRGLAALLQVGLPVLEGALERSVALAASMDARGYG
                     RTARVPRAVRRTTSALTLGGLMGVCAGTYGLLADQGAGYGMPVLLAGLAAALAGLWLGG
                     RRSVRTRYRPDRWGVRAWLVSGSGVAVAALMIQANAYAAAALHPPAVPLTAPQLPVWPA
                     AAILIGLLPAFVAPAPAD"
     gene            complement(5680..6348)
                     /locus_tag="AS857_RS19830"
     CDS             complement(5680..6348)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070570.1"
                     /locus_tag="AS857_RS19830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SCO2322 family protein"
                     /protein_id="WP_058044638.1"
                     /transl_table=11
                     /translation="MTRGGAVAALAAVLLTLLGTAPAQAAGYRYWSFWQGSGGQWAYAT
                     QGPATARPGDGEAVGFRFAVSADSSDAAKPRAAADFGAVCDSTAAKDGTKRVAVVLDFG
                     TAADAPGGETPPAARSACAQVGEDATAGEALAAVAKPLRYDSSALLCAIAGYPRTGCGE
                     QVGGAKKDSRGTESAQPGPAGSEGSDGDGGGPSAGLIGGIAAVVVLGAAAFWQARRRRG
                     "
     gene            complement(6375..7649)
                     /locus_tag="AS857_RS19835"
     CDS             complement(6375..7649)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060238.1"
                     /locus_tag="AS857_RS19835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_058044639.1"
                     /transl_table=11
                     /translation="MAPSLVVHARRGAAVLATAAALSTAVVPAAVADGSPSPAAPGLYG
                     TTDPKFDGVFRQSLAFMAQSTAGVTPAKQAVDWLAGQQCADGGFPGYRADTSKACDPKK
                     DEFTDATAAAVQGLAAAGGRADAVKKGLDWLKAHQNEDGGWGYQAGSPSDANSTSITLG
                     AFAAAGQDPAKDAVKNGKNPVETLLTFQLGCDAKEEGERGAFAYLKDDKGLRADNLASA
                     AAALATRGKGYLVEPPKKDADQPVKPLECSGDDKAGPKDAAAAAEAVDGYLVATMDKNG
                     GYLLPSMPGAPAKPDQGNTADAALALAAGGHRSAAEKPLKWLQSKESGTAEWAKDQPGR
                     LAKLILATRAAGGNPHDFAGTDLVEQLNATGPAPEKKATGGMGTEEKKDDDSVTVNVWW
                     IVGVGLAFGAGIGFLISGRKKKQQL"
     regulatory      complement(7826..7968)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    7945..7957
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    7951..7968
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.25"
                     /tool="antismash"
     gene            8106..9605
                     /locus_tag="AS857_RS19840"
     CDS             8106..9605
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239052.1"
                     /locus_tag="AS857_RS19840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_058044640.1"
                     /sec_met_domain="Aldedh (E-value: 1.8e-152, bitscore:
                     505.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRDLNRDGNGLIEHGQLFIGGTMTDPAGRAVIDVVSPHSEEVIG
                     RVPHASREDVDRAVAAARTSFDSGIWADRPAAERIEVVTRIKDGIAARHEELARTVSAQ
                     NGSPYSWSVLAQALGAMMVWDCAIAVARDLPYEERRAGALGPLLVRREPVGVVAAVVPW
                     NMPQLVAAAKLAPALLTGCSVVLKPSPETPLDSYLLAEIVTEAGLPEGVLSILPAEREV
                     SEYLVGHPGVDKVAFTGSVAAGKRVMEVAARNLTRVTLELGGKSAAIILPDADLDAAVT
                     GIVPSAWMNNGQACVAQTRILAPRAHYAELAERFAAAASALVVGDPLDPATQVGPLVAE
                     RQRRRSLEYIALGQREGAKVLAGGGRPADRGTGWYVEPTLFGDVSNAMRIAREEIFGPV
                     ICLLPYDTEEEAVHIADDSDYGLSGSVWTRDPERGIEVARRVRTGTYSVNTFGLDMFGP
                     FGGYKNSGLGREFGPEGFAEYLEHKTIHLPAGHGEPAGGEA"
     gene            9609..9857
                     /locus_tag="AS857_RS19845"
     CDS             9609..9857
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539159.1"
                     /locus_tag="AS857_RS19845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ferredoxin"
                     /protein_id="WP_058044641.1"
                     /transl_table=11
                     /translation="MADERWRVRVDRGLCVGSGMCAGYAPEAFALDAGHRSRPVAEETD
                     ASGPLFTAAESCPVEAITISALDTGEPVFPPDFPPEE"
     misc_feature    9899..9916
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            10001..12862
                     /gene="lanKC"
                     /locus_tag="AS857_RS19850"
     CDS             10001..12862
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983511.1"
                     /locus_tag="AS857_RS19850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_058044642.1"
                     /sec_met_domain="micKC (E-value: 1.8e-144, bitscore: 480.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.1e-08, bitscore: 30.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-11, bitscore:
                     41.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDARYEVYCLADRHFYETPDRLSVPGADGGGAQEAGLYETARRPA
                     PAGWSTARHGDWLHVFPTGEDGGPRPGPLQGWKIHVSATADTADKTASDVWDYCVARDI
                     PFKFVPGPHLLHLRNNKYAERGHSGKFVTVYPSGEEQLHTTLAGLHEIIGGRPGPYILT
                     DLRWHEGPLYVRYGAFTRRFCIDGRGTLVPAIEDGDGKLVPDSRNPAFQVPAWVTLPGF
                     LAPHLAARNATTVGDLPYRIEKALHFSNGGGVYSGTDTRDGRKVVLKEGRPHAGLAADG
                     ADAVARLEREKDALERLAGLGVAPEPRDWLTIGDHRFLVMDFVEGKPLNSFFAHRHPLL
                     AADPEPTATADYTAWALRIHRAVEEAVEKVHARGVVFNDLHMFNIMVAPDEESVVLIDF
                     EAAAPASEHGRQVVAHPGFFAPPDRRGADVDRYALACLRLALFLPITTLFVIDRAKAAH
                     LADVIAEQFPVPREFLDEAVAEITRGAGTVAEPAGTAAGTVAVADSPGRAALPSPGPAA
                     AAPEASAGAAEEAAAPAVSAASGPAGRRTHTLAPGAGRALAPHALPDPAEDWPRARASM
                     VRGLLASATPERDDRLFPGDIAQFAEGGGLGLAHGAAGVLHALAEAGAERYEEGEQWLL
                     QHTAPVPSGTPLGLYDGLAGVACTLDRLGHTQRALDLSGLMLGEQWQRLTSDLRSGLAG
                     VGLALDHLARTTGERQLHDQAVEAAQLLADRLAADSSGQEEDAGAPRRRAGLMRGASGP
                     ALLFLRLYERTGAPALLDLAGQALRTDLARCTRTDNGTLEVDEGWRTMPYLGDGSAGIG
                     MVLDDFLALAPDPDPYFTEARDGILTAARSRFYAQPGLFQGRAGMILHLARTTAPGATA
                     EHLAAQVRGLSWYAMSYQGELAYPGSQMMRLSMDLATGTAGCLLALAAALDDDGARPAG
                     PAQLPFLAPPRGPRSRLHAVVEP"
     gene            12976..13101
                     /locus_tag="AS857_RS19855"
     CDS             12976..13101
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983510.1"
                     /locus_tag="AS857_RS19855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_058044643.1"
                     /transl_table=11
                     /translation="MALLDLQNMESDENTGGHGGGGQSTVSLLSCVSTASVLICL"
     CDS_motif       12976..13035
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQNMESDENTGGHGG"
                     /locus_tag="AS857_RS19855_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13036..13101
                     /prepeptide="core"
                     /locus_tag="AS857_RS19855_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="17.40"
                     /molecular_weight="1912.2"
                     /monoisotopic_mass="1911.0"
                     /core_sequence="GGQSTVSLLSCVSTASVLICL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQNMESDENTGGHGG"
                     /leader_location="[12975:13035](+)"
                     /alternative_weights="1930.3"
                     /alternative_weights="1948.3"
                     /alternative_weights="1966.3"
                     /alternative_weights="1984.3"
                     /alternative_weights="2002.3"
     gene            13216..14919
                     /locus_tag="AS857_RS19860"
     CDS             13216..14919
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940770.1"
                     /locus_tag="AS857_RS19860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058044644.1"
                     /transl_table=11
                     /translation="MAHTRTATASAGDRLLLGTARHSAGRAAALALLAVASTGAALLLP
                     VTLGHTLDLLLARHGADAGRWVALCALLVAGPAALDALTELLTGTTAARATARLRHRLL
                     GHVLAAGPRTTGRFPPGDLVTRLVGNAADTGTAPATLAHAAASVAGPVGGIVALGLIDP
                     WLALAFLAGAPLLAVLLRAFTRASTDCVARYQQLQGDIAGRLVEALDGARTIAAAGTAA
                     REEARILRPLPGLSRQGHRMWRVQGRSTAQAGTLVPLLQITVLAVAGLRLSQGLLTVGD
                     LLAASRYAVLATGVGMLVGHLNAAARARAAAARAAEVLAVPEVPYGERPLPPGPGTLEL
                     RGVSVVRGGRTVLHEVSVTVPGGTSLAVVGRSGSGKSVLAQAAGRLTDPDAGTVLLDGV
                     PLPALRRDDLRRAVGHAFARPALLGGTVGGTIGFGAVTPGREAREAAARAACAHDFVRR
                     LPRGYDTPCADAPLSGGEAQRLGLARAFAHTGRLLILDDATSSLDTATERRVTAALHAS
                     SAPTRVLIAHRVTTAASTDRVLWLHEGRTRAVAPHAELWADPEYRAVFNA"
     misc_feature    complement(15079..15099)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 17.93"
                     /tool="antismash"
     gene            15108..17015
                     /locus_tag="AS857_RS42110"
     CDS             15108..17015
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655806.1"
                     /locus_tag="AS857_RS42110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_338058269.1"
                     /transl_table=11
                     /translation="MTPVEPGLVRRGVRYLAGRRRVVAVLLAWSVVEAGHTFALGYALA
                     EALDAGFLAGRPRTGLAWLGLAAVAVVVGAYGTGRTYGGVAGLVEPFRDGLVRTVVSRA
                     LHRGDTAAVSRLTHQVEIARDAFAGLVMVSRSFVFTAAGALTGLFLLAPALLAVVAPPL
                     VLGLALFLATLRPLARRQEAYLAADEALAAALGDVFSGLRDVTAAGAEPRVRAETGALT
                     DAALHASRSLARWSVVRVVALALAGQLPVVLLLAGAPWLLDRGVTAGALVGALAYLTQS
                     LMPALQNLVHGLGTSGSRLAVVVRRLTAPGPPVTGVADIPSATPPSTSTPTPALELRHL
                     TFAYGDRADPVVRDLDLTLPRGAHLAVVGPSGVGKSTLAGLVAGLLRPGGGEVTVGGAR
                     AGTAAAAAQRVLIPQEAYVFSGTLADNLGYLRAAPVPETELRAAAEALGMEGLVRRVGG
                     FEAPLAPAELSAGERQQIALARAYLSPAPLAVLDEATCHLDPVAEARAERAFARRPGGT
                     LVVIAHRAASARRAGRILVMDGADTACGEHHELLARSPLYRDLMGAAESMDPAHPAHPA
                     APAPRNPSHPPRHLRDTDRVDPVPCPGLAGDGGHVVAHRPVGQVEAAGDLPDGRPLRRE
                     "
     gene            complement(<16941..17351)
                     /locus_tag="AS857_RS37900"
                     /pseudo=""
     CDS             complement(<16941..17351)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="AS857_RS37900"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSDSLRPHVCVVDMDSPEAGGPGGLRELSGHGDARDDRAALLALA
                     SAGRPGPLRRAYEEKALGYLSKNASPDRLVEGIRHVANGERYIDETLGFGFLEASEMPL
                     TRRELSVLSLAAEGASVGEIARSLHLSNGTVRN"
     gene            complement(17662..18300)
                     /locus_tag="AS857_RS19875"
     CDS             complement(17662..18300)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982955.1"
                     /locus_tag="AS857_RS19875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_058044646.1"
                     /transl_table=11
                     /translation="MTTEPKSPTARAVLAGPSLPLTERQEARRRRILQATTELASRGGF
                     DAVQMREVAEAAGVALGTLYRYFPSKVHLLVATMQDQLQRLHGTLRKRPPTDADPAARV
                     AQTLMRAFRAMQREPHLADAMMRALTFADRSVSAEVDTVSRLTTAIILDAMGPAGPPSP
                     EQLSAVRVIEHTWHSALITWLSGRASIAQVRIDIETVCRLIRLTTPQQA"
     misc_feature    complement(18451..18464)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            18630..19895
                     /locus_tag="AS857_RS19880"
     CDS             18630..19895
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010637585.1"
                     /locus_tag="AS857_RS19880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_245700623.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.2e-28,
                     bitscore: 96.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIALLTYKGNPFCGGQGVYVRHLSRELARLGHSVEVIGSQPYPV
                     LDEGVTLTELPSLDLYRQPDPFRTPGRDEYRDWIDALEVSTMWTGGFPEPLTFSLRARR
                     HLAAQRGRFDVVHDNQTLGYGLLGGPDAIGAPLVTTIHHPITVDRQLDLAAAADWKRRA
                     SVRRWYGFTRMQKRVARRLPSVLTVSGSSRQEIVDHLGVRAERVHVVPIGADTDLFSPD
                     PSVPEVPGRIVTTSSADVPLKGLIHLIEALAVVRRRHPDAHLVVVGKRAEDGPIATAIR
                     RCGLEGAVEFVKGITDAELVGLVRSAQVACVPSLYEGFSLPAAEAMATGTPLAATTGGA
                     IPEVAGPDGETCLAVPPGDSGALASALDRLLGDPGLRRRLGAAGRERVLSRFTWREAAL
                     GTARHYREAIALAGARPAGRRG"
     gene            20032..20766
                     /locus_tag="AS857_RS19885"
     CDS             20032..20766
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180171.1"
                     /locus_tag="AS857_RS19885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_058044648.1"
                     /transl_table=11
                     /translation="MLTVDFSRFPLAAGDRVLDLGCGAGRHAFECYRRGARVVALDRNG
                     EEIREVARWFAAMKEAGEAPAGATATAMEGDALALPFPDDSFDVVIISEVMEHIPDDKG
                     VLAEMVRVLKPGGRIAVTVPRYGPEKICWALSDAYHEVEGGHIRIYRGDELLDRMREAG
                     LEPYGTHHAHGLHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPVATRVAEQALN
                     PLIGKSFVAYATKPHLPAGAEA"
     misc_feature    20036..20050
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     gene            20763..21845
                     /locus_tag="AS857_RS19890"
     CDS             20763..21845
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953108.1"
                     /locus_tag="AS857_RS19890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prenyltransferase"
                     /protein_id="WP_058044649.1"
                     /transl_table=11
                     /translation="MTFFSRGSGRTERLVLPGVLTAEQVTGTVAGIAAVQREDGAIPWF
                     RGHHLDPWDHVEAAMALDAAGEHGRAEAAYRWLARHQNADGSWFAAYADGAADEPTDRS
                     RESNFVAYVAVGVWHHYLATGDDAFLDSMWPTVYAAVEFVLALQQAGGQIGWKREDDGT
                     PVTDALLTGSSSIHQALRCALAIAEHREEPQPDWELATGLLAHAIRRHPERFLDKGRYS
                     MDWYYPVLGGAVTGVAAKERIEEGWDRFVVPGLGVRCVLPNPWVTGGESCELALALWVM
                     GESDRAVQILQWIQHLRAEDGMYWTGYVYDDDAVWPEERTTWTAGSLLLAAAALGGDEA
                     TTAVFGGERLPSGLEPDCCP"
     gene            21930..22742
                     /locus_tag="AS857_RS19895"
     CDS             21930..22742
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019764970.1"
                     /locus_tag="AS857_RS19895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_173864785.1"
                     /transl_table=11
                     /translation="MTMTLSHDRYCSEILHQTELLRGALGEGADVSVTVPTCPEWTLGQ
                     LLLHVGQAHRMATGLVRDQVKEFVPPSTAAQGGPAPAPGEPSADDLPALAAWLGEGAEA
                     LVAVLREAGPDSPVWTFSEDQRSVFWARRMTHETLMHRADALGALGVPFTAEPEVAADC
                     VDEWLDILTFPAAVAFKPRLAELPGPGRTLHLHATDTPAELDAEWFIDLTGEGVSWRRA
                     HEKAAVAVRGPVTDLLSVLFQRLPADSDRVEVLGDRELLDFWLDRAVF"
     misc_feature    complement(21931..21945)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
ORIGIN
        1 gtcgaccaca agcggcggtt cgccaccccc gactggtcgt cgcgcggctt cgccaacgcc
       61 tgtccgcgcg acagcatgct cgtgatcggc gacgagatca tcgagacccc gatggcctgg
      121 ccgtgccgct acttcgacac ccacccctac cgcacgctcc tcaaggacta cttccggcgc
      181 ggcgcgcggt ggacggcggc gccgaagccg cagctcaccg acgcgctgtt cgaggcggat
      241 ttccgtgccc ccgcgccggg cgagcccgtg cgccgcatcc tcaccgagtt cgagccggtg
      301 ttcgacgccg cggatttcgt acgcgccgga cgcgacctgt tcgtgacgcg gagcaacgtc
      361 accaaccgca tgggcatcga gtggctgcgc cgtcacctcg ggcccggcta ccgcatccac
      421 gagatcgaga gccgctgccg cacgcccatg cacatcgaca cgacgttcct tccgctcgcg
      481 cccggcaagg tgctggtcaa ccccgagtac atcgacgtcg gccggctgcc cgacgtcctg
      541 cgttcctggg acgtcctggt cgcccccgaa cccgacccga tcgaggaccg cctgctccgg
      601 atcacctcga tgtgcggcaa gtggctcagc ctgaacgtcc tggtgatcga cggcaccagg
      661 gtggtggcgg agcggcacca cacccgcatg ctgcgcgcgc tggagcgatg ggggttcgag
      721 cccgtcccgt gcgacctgct gcactacgcg ccgttcggcg gctcgttcca ctgcgcgacg
      781 ctcgacgtcc ggcgccgcgg cacgctcgca tcgtattgcc cgtgacctgc gaccggtgac
      841 ccgcgggcgg gccgaggacg aggtcctgct cctcgggcgt cagcgcggct ccccgaacgt
      901 caccggtgcg tcgaacgccg ccctccgcgt cgcccgccgc agcgccttca ggaccgtcgg
      961 gccgagcgtg agcgtcgccg tgaccgtcac gaccgcgcgc ggcacgtccc agcccaggga
     1021 agtcgccagg cagtacgcga cgaagcgggc gaggttctcc tcgaccgggt cgcccgggac
     1081 gaaggagacg cccgtggcga gcgagccgat gtacggccag ccctggaggt tcatcaccgt
     1141 gccgtagagg agggaggcca ccgcgccgta gcccgcgagc atcagcacct cgcgggggcc
     1201 gcgcaggcgg tcggggccgg gcagcaggcc cgcgcccatg gccacccacc ccatcgacag
     1261 catctggaac ggcatccagg gcccgacgcc gcccgtcagc agcgccgacg cgaacatcga
     1321 caccgcaccg agcacgaagc cgaagccggg gccgaggacc cggcccgaca gcaccatcag
     1381 gaagaacatc ggctcgatgc ccgccgtccc cgcgcccagc ggccgcaggg ccgcgcccgc
     1441 cgccgccagg acgccgagca tcgcgatcgc cttcgcgtcc aggcccgagt cggcgatggc
     1501 cgccaccacg acggccagca gcagcggcag cagggccgcg aacagccacg gcgcgtcctg
     1561 ggagtgcgcg aggcccgacg cggagtcggc gagcaggggc cagccgaagg ccgccacccc
     1621 ggtcgcggag acgaggagca gggccgcgat cgagcgcctg ccgaggcgta tcgctcgcgc
     1681 ttggcggtcg ggagcggcgc tgccgcggcc gggtgcggtg ttctcgcggt cggggccggt
     1741 gtccccgcgg ccgggtgtga cgttcttccc gtcgggtgcg gagtcctcgc ggtccggtgc
     1801 ggcgtccgtc acgagcccgc ctccagcgcg tcccgcacct gtcccaccgt cagccacggc
     1861 tgcggcgcga ggaccttggc cacctgcggc gcgaaggccg gcgaggagac caccacctcg
     1921 gccgtcgggc cgtccgcgac gatctcgccg tcggcgatga cgacgacccg gtgggcaagc
     1981 tccgcggcca gttccacgtc gtgcgtcgcc aggacgatcg cgtgcccctc ggcggcgagg
     2041 ccgcgcagga tctccaccag gcggtgcttg gccgcgtagt cgaggccgcg ggtcggctcg
     2101 tcgaggagga tcagcggcgg gctcgccgtc aggacgaccg cgagggcgag cgcgaggcgc
     2161 tggccctccg acaggtcgcg cgggtgcgtc gtgccgggga cgtccgggag gagccgggag
     2221 acgagcgcgc ggcaggtgcc cggttccgcg cccgcgtcac cgtcggccgc cgcgcactcg
     2281 gcggcgaccg tgtccgcgta cagcaggtcg cgcggctcct gcggtacgag gcccacgtgg
     2341 cgcagcagtt ccgccggggt cgtgctctgc ggggcggcgc cgcccacgcg cacggagccc
     2401 gcggcgggct tgtgcatgcc gacgagcgtg cgcagcagcg tggacttgcc cgcgccgttg
     2461 cggcccatca gcgcgaccgt ctccccggcc cgtacggaca ggttcacgtc gcgcagcgcc
     2521 accagccggc cgtgccggac ggcgagcccg gcggcggccg cggcgggggc ggggccggtg
     2581 tccgccgtgc ggcgggcctt gcgcaggaag ccggcgcggc gggtgcgggc cgtgacgccc
     2641 tccgcgccct gcggggcggg tgcggccggc ggggccggcg ggggccgccc cccccccccg
     2701 gcgcgggggg ggggggggcc cgccgccggt ttcacagcgc cggtggcaca gcaatactgt
     2761 tcgacaccga caggtgcgga acagagagcg aggtgccgcc catggccgcg gagacggaga
     2821 ccggggaagc gaccctgacg gtggacgagt tggccgcccg ggccggggtg accgtccgca
     2881 ccgtgcgctt ctacagcacc cgggggctgc tggaagcgca cggtgcggac ggtcaccccg
     2941 gcccgggcgg ccaactcgtc caccgtcagg gtcgcttccc cggtctccgt ctccgcggcc
     3001 atgggcggca cctcgctctc tgttccgcac ctgtcggtgt cgaacagtat tgctgtgcca
     3061 ccggcgctgt gaaaccggcg gcggcccccc cgcccccccg cgcgcggggg ggtgggggcg
     3121 ggcctgtgtg caggaccggt caggatccgt cagggccggt caaggcccat caagcccccg
     3181 tcaaggccgg tcagtgccgg tgggcgcggg ccccgccccc gccgcggccg ccgccgggct
     3241 cgccgtccgg cacggccggc tggtggcgct gcgcgacgtg aacctgtccg tacgggacgc
     3301 gcgccgcatg gcgccggccc tgcgggtgcg gccggcgggg ccggcggggc cagccgctcc
     3361 cgcagggccg gcgccatgcg gcgcgcgtcc cgtacggaca gggggagcgg cgaccagccg
     3421 gccagccggc ccaggtcgac gacgggcggg tggaccggcg acaccgccat gacctcggcc
     3481 ggctcgccca tgaccggggc ctgcccgggg ccgggcagca ggatgacgcg gtccgcgtac
     3541 tgcacgaccc gctccagccg gtgctcggcc atcaggaccg tggttcccag gtcgtggacc
     3601 aggcgctgca ggacggcgag cacctcctcg gccgcgcccg ggtccagggc ggacgtcggc
     3661 tcgtcgagga ccagcacctt cgggtgcgtg gtcagcaccg agccgatcgc gacgcgctgc
     3721 tgctgcccgc cggagagcgt ggcgatgggg cggtcgcgga gggtcgccag gcccagcagg
     3781 tcgagggtct cctcgacgcg gcgccgcatg gtgtgcgggg ggatgccgag ggactccatg
     3841 ccgtacgcga gctcgtcctc gacggtgtcg gtgacgaagt gcgcgagcgg gtcctggccc
     3901 acggtgccga cgacgtcggc gagttcgcgc ggcttgtggg tacgggtgtc gcggccggcg
     3961 acggtgacgc ggccgtgcag ggtgccgccg gtgaagtgcg ggacgaggcc gctgacggtg
     4021 ccgaggaggg tggacttgcc gacgccggac gggccgacga gcaggcagag ttcgccctcg
     4081 gggacggtga ggtcgacctc ttggagggag ggtgcctcgg cgtcgtcgta ggtgaccgac
     4141 acctgctcga agcggatcac tcggagggct cctcggggtg ggtcgtgcgg gtcgtttcgg
     4201 caccgccggg ctccccggcg ggggctgagc gccgccgcgg cgggagacct tccgggggct
     4261 cgcccccgga cccgcggggg ccggggcgca gccccgggaa acggtgaagg ggcgggaccg
     4321 gggcatcttc tcccgccgca gcggtgctcc gcccccaccg gcctgcccgg cggtgcccgg
     4381 cagcctccgg ctcggccgtc cccggttcgg cagggcccgg ctcggcggcc cgctgcgggc
     4441 gcctcgcggt ccccggcccg gtggccgcat cccgcgagcc cccgtcggcg ggcgccggcg
     4501 ccacgaacgc cgggagcagg ccgatcagga tcgccgccgc cggccacacc ggcagctgcg
     4561 gcgccgtcag cggcaccgcc ggcggatgca gcgcggccgc cgcgtaggcg ttcgcctgga
     4621 tcatcagggc cgcgacggcc acgccagagc ccgataccag ccaggcccgt acgccccacc
     4681 ggtccggccg gtagcgcgtg cggacggagc ggcggccgcc cagccacagg cccgccagtg
     4741 cggcggcgag gccggccagc aggacgggca tgccgtagcc cgcgccctgg tcggcgagca
     4801 gcccgtacgt gccggcgcag acgcccatca ggccgcccag cgtcagcgcg ctcgtggtgc
     4861 ggcggaccgc gcgcggcacc cgggccgtgc ggccgtagcc ccgcgcgtcc atcgacgccg
     4921 ccagcgccac ggaacgctcc agcgcgccct ccagcacggg caggcccacc tggagcaggg
     4981 cggcgaggcc gcggtcgggg cgcccgcgca ggcggcgggc ggcgcgcagc cgctggacgt
     5041 cggcgacgag gttcggcgcg aacgtcatcg cgacgacgac cgcgacgccc gcctcgtaca
     5101 gcgccccggg cagggacttc agcagccgcg ccgggctggc gagcgcgttg gccgcgccca
     5161 cgcacaccag cagcgtggcc agcttcatgc cgtcgtagaa cgcgaagagc agcccctcgg
     5221 ccgtcacccg gccgccgagc cgcacccccc gcgcccagtc cggaagcggc acctccggca
     5281 ggacgaagag cgtgtgcgtg ccggggatcg gggagcccag cacgatcgcg aagacgaggc
     5341 ggatgccgat gacggcgagg ccgagcttga ggaacgcccc gtacgagcgc gcccagggcg
     5401 cgtccgtgcg tcgcgcggcc acgacgtagc cggcgacggc gatgagcagg ccgagcagca
     5461 ggacgttcgt ggtgcgggag gccgccgcgg ccaggccgag cgcccacacc caccaggcgc
     5521 ccgcgtgcag tgcggaggcg cgcgaggtca gcggcgcgcc cccgacgccg gcctcggcgc
     5581 caccgccggc accggcgctg acaccagcac cagcactggc ccgggcaccg gcccgggcgc
     5641 ccacccctgc cccgccccgc ggaggcttct tcctgtcgct catccgcggc gtcggcgggc
     5701 ctgccagaag gccgcggcgc ccaggacgac cacggcggcg atgccgccga tcaggccggc
     5761 cgagggacca ccgccgtcac cgtcggagcc ttcgctcccg gccgggcccg gctgagcgct
     5821 ctccgtgccc cgggaatcct tcttcgcgcc accgacctgc tcgccgcagc cggtccgcgg
     5881 gtagccggcg atggcgcaca gcagcgcgga ggagtcgtag cgcagcggct tggcgacggc
     5941 ggccagcgcc tcgcccgcgg tcgcgtcctc gcccacctgg gcgcaggccg agcgggcggc
     6001 gggcggcgtc tcgcccccgg gggcgtccgc ggccgtgccg aagtcgagga cgacggcgac
     6061 gcgcttcgta ccgtccttgg cggcggtgct gtcgcagacc gccccgaagt cggcggcggc
     6121 gcgaggcttc gcggcgtcgg aggagtccgc actgacggcg aaccggaacc cgacggcctc
     6181 gccgtcaccg ggccgggccg tggccggacc ctgcgtggcg tacgcccact gcccgccgga
     6241 gccctgccag aacgaccagt accggtaccc ggcggcctgc gcgggggccg tgccgaggag
     6301 ggtgaggagc acggcggcga gcgcggcgac cgcgccgccg cgcgtcaccg cgccccgtgc
     6361 cgcagccgct cgcgtcacag ctgctgcttc ttcttgcggc cgctgatcag gaagccgatg
     6421 ccggcgccga aggccaggcc gacgcccacg atccaccaca cgttgacggt gacggagtcg
     6481 tcgtccttct tctcctccgt ccccatgccg ccggtggcct tcttctccgg ggccgggccg
     6541 gtggcgttca gctgctccac caggtcggtg cccgcgaagt cgtgcgggtt gccgcccgcg
     6601 gcgcgggtgg ccaggatcag cttggcgagg cggccgggct ggtccttggc ccactcggcg
     6661 gtgccgctct ccttggactg cagccacttc aggggcttct cggcggccga gcggtggccg
     6721 ccggcggcga gggcgagggc ggcgtcggcg gtgttgccct ggtcgggctt ggcgggggcg
     6781 ccgggcatgg acggcagcaa gtagccgccg ttcttgtcca tggtggccac gaggtagccg
     6841 tcgacggcct cggcggcagc ggcggcgtcc ttgggcccgg ccttgtcgtc gccggagcac
     6901 tccagcggct tgaccggctg gtcggcgtcc ttcttcgggg gctcgacgag gtagcccttg
     6961 ccgcgcgtgg cgagcgcggc ggcggcgctg gcgaggttgt cggcgcgcag ccccttgtcg
     7021 tccttgaggt acgcgaacgc gccgcgctcg ccctcctcct tcgcgtcaca gccgagctgg
     7081 aaggtcagca gcgtctcgac ggggttcttg ccgttcttga cggcgtcctt ggccgggtcc
     7141 tgaccggccg cggcgaacgc gccgagggtg atggaggtgg agttggcgtc gctcgggctg
     7201 ccggcctggt agccccagcc gccgtcctcg ttctggtggg ccttgagcca gtcgaggccc
     7261 ttcttcacgg cgtccgcgcg cccgccggcc gcggcgaggc cctgcacggc cgcggcggtg
     7321 gcgtccgtga actcgtcctt cttggggtcg cacgccttgc tcgtgtcggc gcggtagccg
     7381 gggaagccgc cgtccgcgca ctgctggccg gcgagccagt cgacggcctg cttggccggg
     7441 gtgacgcccg ccgtgctctg cgccatgaag gccagggact gccggaagac gccgtcgaac
     7501 ttggggtccg tggtgccgta gagcccgggg gcggccgggg acggggagcc gtcggcgacg
     7561 gcggcgggga ccacggccgt gctcagggcg gcggcggtgg ccaggaccgc ggcgccgcgg
     7621 cgcgcgtgga cgacgaggga gggggccatg gggtcgtgcc tctcgggtgg gtgtcactgc
     7681 ggtggccggc gtgccggggt gcgcggcggc gcagccgggc gcggctgccg ccccgcgagc
     7741 ttcgcgcggt ggcaccgggc tcggctccgc atacctcgac ggtgccggtg gaccgggcgg
     7801 caccgccagg cggtacgacc ggctccggaa gcctgccgcc tggcccgggt ggtccggctc
     7861 gtacggccgc gccgggcggc gggccgtagt cacggttgcg ggtcagcgcc ggatttgcac
     7921 cggcttcccc cgttccgagg cgggatgaag ttgtcacgga cactttaacc ggccgggtcg
     7981 gcggccggcc gtccggcggc ggggccgccg accccgttgc cgcggcgccg gaggagctgc
     8041 taactgtctg atgcagcgtc agatccgacg ctcagggctc cgcagacgcg cgggaggcat
     8101 cggacatgaa ccgggacctg aaccgggacg ggaacggact gatcgagcac gggcagctct
     8161 tcatcggcgg caccatgacc gacccggccg gccgcgccgt catcgacgtg gtgtcgccgc
     8221 actccgagga ggtcatcggc cgcgtcccgc acgcctcgcg cgaggacgtc gaccgcgcgg
     8281 tggccgcggc ccgcacctcc ttcgactccg ggatctgggc ggaccggccg gcggccgagc
     8341 gcatcgaggt cgtcacccgg atcaaggacg gcatcgccgc ccggcacgag gagctggccc
     8401 gcaccgtctc cgcgcagaac ggctccccct actcctggag cgtcctcgcc caggccctcg
     8461 gcgcgatgat ggtgtgggac tgcgcgatcg ccgtcgcccg cgacctgccc tacgaggagc
     8521 ggcgggcggg cgccctcggg ccgctgctgg tgcggcgcga gcccgtcggc gtcgtcgcgg
     8581 ccgtcgtgcc gtggaacatg ccgcagctgg tggccgcggc caagctcgcg cccgcgctgc
     8641 tgaccggctg ctcggtggtg ctcaagccct cgcccgagac gcccctggac tcctacctgc
     8701 tggcggagat cgtcaccgag gcgggcctgc cggagggcgt gctgtccatc ctccccgcgg
     8761 agcgcgaggt cagcgagtac ctcgtcggcc acccgggcgt cgacaaggtg gccttcaccg
     8821 gctcggtcgc ggcgggcaag cgcgtcatgg aggtcgccgc gcgcaacctc acccgcgtca
     8881 ccctggagct cggcgggaag tccgcggcga tcatcctgcc ggacgccgac ctggacgcgg
     8941 ccgtcaccgg catcgtcccc agcgcctgga tgaacaacgg ccaggcgtgc gtcgcccaga
     9001 cgcgcatcct cgccccccgc gcccactacg ccgagctggc cgagcgcttc gccgcggccg
     9061 cctccgccct cgtcgtcggc gaccccctcg accccgccac ccaggtcggc ccgctcgtcg
     9121 ccgagcggca gcggcggcgc tcgctggagt acatcgcgct cgggcagcgc gaaggggcca
     9181 aggtgctcgc cggcggcggc cggccggcgg accgcggcac cggctggtac gtcgagccca
     9241 ccctcttcgg cgacgtctcc aacgccatgc ggatcgcccg cgaggagatc ttcggccccg
     9301 tgatctgcct cctgccctac gacacggagg aggaggccgt gcacatcgcc gacgactccg
     9361 actacgggct ctccggcagc gtctggaccc gcgaccccga gcgcggcatc gaggtcgccc
     9421 gccgggtgcg caccggcacg tactcggtca acaccttcgg cctcgacatg ttcggcccct
     9481 tcggcggcta caagaactcc ggcctggggc gggagttcgg gcccgagggc ttcgccgagt
     9541 acctggagca caagaccatc cacctgcccg cgggacacgg ggagcccgcc gggggagagg
     9601 cgtgaccgat ggcggacgag cgctggcgcg tgcgggtcga ccgggggctg tgcgtgggct
     9661 cggggatgtg cgcggggtac gcgcccgagg cgttcgcgct cgacgcgggg catcgctcgc
     9721 gcccggtcgc ggaggagacg gacgcatccg gcccgctgtt cacggccgcc gagagctgcc
     9781 cggtggaggc catcacgatc agcgccctgg acacgggtga gcccgtcttt cccccggact
     9841 tccccccgga ggagtgaagc ggaggcgtgt gcagcaacgc cgttcgcacg cacgcgcgtt
     9901 gttactcatg cgttccgcac acttccttga tgacacatgt gactggccgg gcccctcacg
     9961 gcgtggaaat ctctaggcaa cgcagccgag gggggcgacg atggacgcgc ggtacgaggt
    10021 ctactgcctg gccgacaggc acttctacga gaccccggac cgcctgtccg tcccgggggc
    10081 ggacggcggg ggagcccaag aggcgggcct gtacgagacc gcccgccgcc ccgcccccgc
    10141 cggctggagc accgcccgcc acggcgactg gctccacgtc ttccccaccg gggaggacgg
    10201 cggcccgcgg cccgggcccc tccagggctg gaagatccac gtctccgcca cggccgacac
    10261 cgcggacaag accgcctccg acgtgtggga ctactgcgtc gcccgggaca tccccttcaa
    10321 gttcgtcccc ggcccccacc tgctccacct gcgcaacaac aagtacgcgg agcgcggcca
    10381 cagcgggaag ttcgtcaccg tctacccctc cggcgaggag cagctgcaca ccaccctcgc
    10441 cggactgcac gagatcatcg gcggccgccc cggcccgtac atcctcaccg acctgcgctg
    10501 gcacgaaggc ccgctctacg tccgctacgg cgccttcacc cgccgcttct gcatcgacgg
    10561 gcgcggcacc ctcgtgcccg cgatcgagga cggggacggc aagctcgtcc ccgactcccg
    10621 caaccccgcc ttccaggtcc ccgcgtgggt gacgctgccc ggcttcctcg ccccgcacct
    10681 cgccgcgcgc aacgccacca ccgtcggcga cctgccctac cgcatcgaga aggccctgca
    10741 cttctccaac ggcggcggcg tctactccgg caccgacacg cgcgacggcc gcaaggtcgt
    10801 cctcaaggaa ggccgccccc acgccgggct cgccgccgac ggagccgacg ccgtggcccg
    10861 cctggagcgc gagaaggacg ccctggagcg gctcgccggc ctcggggtcg cccccgagcc
    10921 gcgggactgg ctcaccatcg gcgaccaccg cttcctcgtc atggacttcg tcgagggcaa
    10981 gcccctcaac tccttcttcg cccaccgcca cccgctgctt gccgcggacc cggagcccac
    11041 cgccaccgcc gactacaccg cgtgggcgct gcgcatccac cgggccgtcg aggaggccgt
    11101 cgagaaggtc cacgcgcggg gcgtcgtctt caacgacctc cacatgttca acatcatggt
    11161 cgcgcccgac gaagaatccg tcgtcctcat cgacttcgag gccgccgcgc ccgcctccga
    11221 gcacggccgg caggtcgtcg cccaccccgg cttcttcgcc ccgccggacc gccgcggagc
    11281 cgacgtcgac cgctacgcgc tggcctgcct gcggctcgcc ctcttcctgc ccatcaccac
    11341 gctcttcgtg atcgaccggg ccaaggcggc gcacctggcc gacgtgatcg ccgaacagtt
    11401 cccggtgccg cgggagttcc tcgacgaggc ggtggcggag atcacgcggg gggcggggac
    11461 ggtggcggag cccgccggga cggcggcggg aaccgtagcg gtggcggatt cgccgggccg
    11521 cgcggcgctg ccgagccccg gcccggctgc ggccgccccg gaagcgtccg cgggcgccgc
    11581 ggaggaagct gccgcgcctg ccgtctccgc ggcctccggc cccgccgggc gccgcaccca
    11641 caccctcgcc cccggcgccg gccgcgccct cgccccgcac gccctccccg accccgccga
    11701 ggactggccc cgcgcccgcg cgtccatggt ccgcggcctc ctcgcctccg ccacgccgga
    11761 gcgcgacgac cgcctcttcc ccggggacat cgcccagttc gccgagggcg gcggactcgg
    11821 cctcgcccac ggcgccgcag gcgtcctgca cgccctcgcc gaagccggcg ccgagcgcta
    11881 cgaagagggc gagcagtggc tcctgcagca caccgccccc gtgccgtccg gcaccccgct
    11941 cggcctctac gacggcctcg ccggcgtcgc ctgcaccctc gaccggctcg gccacaccca
    12001 gcgcgccctc gacctgtccg ggctcatgct cggcgagcag tggcagcgcc tcacctccga
    12061 cctgcgcagc ggcctggccg gcgtcggcct cgccctcgac cacctcgccc gcaccaccgg
    12121 cgaacgccag ctccacgacc aggccgtcga agccgcccag ctcctcgccg accggctcgc
    12181 cgccgactcc tccggccagg aggaggacgc cggcgcaccc cgccggcgcg ccggcctcat
    12241 gcgcggcgcg agcgggcccg ccctgctctt cctgcggctg tacgagcgca ccggcgcccc
    12301 ggccctcctc gacctcgccg ggcaggccct gcgcaccgac ctcgcccgct gcacccgcac
    12361 ggacaacggc accctcgaag tcgacgaggg ctggcgcacc atgccctacc tcggtgacgg
    12421 cagcgccggc ataggcatgg ttctggacga cttcctcgcc ctcgccccgg accccgaccc
    12481 gtacttcacc gaggcccgcg acggcatcct caccgccgcc cgctcgcgct tctacgccca
    12541 gcccgggctg ttccagggca gggccgggat gatcctgcac ctcgcccgca ccaccgcgcc
    12601 cggcgcgacc gcggagcacc tcgccgcgca ggtccgcgga ctgtcctggt acgccatgtc
    12661 ctaccagggc gaactcgcct accccggcag ccagatgatg cggctgtcca tggacctcgc
    12721 caccggaacg gccggctgcc tgctcgccct cgccgccgcc ctcgacgacg acggcgcccg
    12781 gcccgcaggg cccgcgcagc tgccgttcct cgcgccccca cgggggcccc gaagccggct
    12841 ccatgccgtt gtggagccgt agcaagaaaa cgcaagtagc aaatagctag tggctagtgg
    12901 ctagtggcta gtggcaacaa gaacaagaga aaccgaaccc cgtccccacg ggaaccccac
    12961 gaaaggaaca cgaccatggc gctcctcgac ctgcagaaca tggagtccga cgagaacacc
    13021 ggcggtcacg gcggcggcgg ccagagcacg gtcagcctgc tctcctgcgt cagcaccgcc
    13081 agcgtgctga tctgtctgtg atccggcacc ggatccggca ctgatccggc accgggcggg
    13141 cccctcctgc gacgaggggc ccgcccgggt ccgcttttcc cctacggatg gtacggacgc
    13201 gagggccacc gatccatggc acacacccgc accgccacgg cctccgccgg agaccggctg
    13261 ctgctcggca ccgcccggca cagcgccggc cgcgccgccg cgctcgccct cctcgcggtc
    13321 gcctccaccg gagccgcgct cctgctgccc gtcaccctcg gccacaccct cgacctgctc
    13381 ctcgcccgcc acggcgccga cgccggccga tgggtcgccc tgtgcgcact cctcgtcgcc
    13441 ggccccgccg ccctcgacgc cctcaccgaa ctcctcaccg gcaccaccgc cgcccgcgcc
    13501 accgcccggc tgcgccaccg gctcctcggc cacgtcctcg ccgcgggccc gcggaccacc
    13561 ggccgcttcc cgcccggcga cctcgtcacc cgcctcgtcg gcaacgccgc cgacaccggc
    13621 accgcgcccg ccacgctcgc ccacgccgcc gcctccgtgg cgggccccgt cggcgggatc
    13681 gtcgccctcg gcctcatcga cccctggctc gcgctcgcct tcctcgccgg cgcccccctg
    13741 ctcgccgtcc tcctgcgcgc cttcacccgc gcctccacgg actgcgtcgc ccgctaccag
    13801 cagctccagg gagacatcgc cgggcgcctc gtcgaagcgc tcgacggcgc ccgtaccatc
    13861 gccgccgccg gcaccgccgc ccgcgaagag gcccgcatcc tgcgaccgct gcccgggctc
    13921 tcccgccagg ggcaccgcat gtggcgcgtc cagggccgct ccacggccca ggccggcacg
    13981 ctcgtgccgc tgctccagat caccgtcctc gccgtcgccg gcctccggct ctcccagggc
    14041 ctcctcaccg tcggagacct cctcgccgcc tcccgctacg ccgtcctcgc caccggcgtc
    14101 ggcatgctcg tcggccacct caacgccgcg gcccgcgccc gcgccgcggc cgcccgcgcc
    14161 gcggaggtcc ttgccgtgcc cgaagtccct tacggggagc ggccgctgcc gcccgggccc
    14221 ggcacgctgg agctgcgggg ggtgagcgtc gtacggggcg ggcggaccgt gctgcacgag
    14281 gtgagcgtga cggtccccgg agggacgtcg ctggccgtcg tcggacgctc cggcagcggc
    14341 aagtccgtcc tcgcgcaggc cgccggccgg ctcacggacc ccgacgccgg caccgtcctc
    14401 ctcgacggcg tccccctccc cgccctccgc cgcgacgacc tgcgccgcgc cgtcggccac
    14461 gccttcgccc ggcccgcgct gctcggcggc accgtcggcg gcacgatcgg cttcggggcg
    14521 gtcacgccgg ggcgcgaggc gcgggaggcc gcggcgcggg cggcctgcgc gcacgacttc
    14581 gtacggcgcc tcccgcgcgg gtacgacacg ccctgcgcgg acgcccccct ctcgggcgga
    14641 gaggcccagc gcctgggtct cgcccgcgcc ttcgcccaca cgggccgcct cctgatcctg
    14701 gacgacgcca cgtccagcct ggacacggcg acggaacgcc gcgtcacagc agccctgcac
    14761 gcgtcgtccg cccccacgcg cgtactgata gcccaccgcg tgacgacggc cgcgagcacg
    14821 gaccgcgtcc tgtggctcca cgagggcagg acaagggcgg tggccccaca cgccgaactg
    14881 tgggccgacc cggaatacag ggcggtcttc aatgcctgag acgacgtcat gaccgccggt
    14941 ccgaccggcg ggggcgggcc accgcggcgg cggtttccct tccacccctg gttgctgaag
    15001 ccggccgggt cggctgcttc ccttccgccg cgacggcgag tcgccccgcg gtgcgtcccg
    15061 gcggtgccgt cccggacgca atcgtcccgc cgactcagga ggtccccgtg acacccgttg
    15121 agcccgggct cgtccggcga ggggttcggt atctcgccgg gcggcggcgc gtcgtcgcgg
    15181 tgctgctcgc gtggtccgtc gtggaggccg ggcacacgtt cgcgctgggg tacgcgctgg
    15241 ccgaggcgct cgacgcgggg tttctcgccg ggcggccccg caccgggctc gcgtggctgg
    15301 ggctggccgc ggtggccgtg gtcgtcgggg cgtacgggac cgggcgcacg tacggcggcg
    15361 tcgccggtct cgtggagccc ttccgggacg ggctcgtgag gacggtcgtc tcccgcgccc
    15421 tgcaccgggg cgacaccgcg gccgtgtccc ggctgacgca ccaggtggag atagcccgtg
    15481 acgccttcgc cggcctggtc atggtctcgc gctcgttcgt cttcaccgcg gccggcgccc
    15541 tgacgggcct gttcctgctc gcgcccgcgc tgctggcggt cgtcgcgccg cccctcgtgc
    15601 tcggcctcgc cctgttcctg gcgacgctgc gcccgctggc ccgccgccag gaggcctacc
    15661 tcgccgcgga cgaggccctc gccgccgcgc tcggcgacgt cttctccggt ctgcgcgacg
    15721 tcaccgcggc gggtgccgag ccccgcgtcc gcgcggagac aggcgcgctc accgacgccg
    15781 cgctgcacgc gtcccgttcg ctcgcccgct ggtccgtcgt ccgggttgtg gccctggccc
    15841 tggccgggca gctgccggtg gtgctcctgc tggccggggc gccgtggctg ctggaccggg
    15901 gcgtcaccgc gggcgccctg gtgggcgcgc tggcctatct gacgcagtcc ctgatgcccg
    15961 cgctgcagaa cctcgtccac ggcctcggca cgagcggctc gcgcctcgcc gtggtggtgc
    16021 gcaggctgac ggcgccgggc ccgccggtga cgggggtggc ggacatcccg tcggccaccc
    16081 cgccgtccac ctccaccccc acccccgccc tcgaactgcg ccacctcacc ttcgcgtacg
    16141 gcgaccgcgc cgaccccgtc gtacgggacc tggacctgac gctgccccgg ggcgcgcacc
    16201 tcgcggtcgt cgggcccagc ggcgtcggga agtcgacgct ggccgggctg gtcgcggggc
    16261 tcctgcgccc gggcggcggc gaggtcaccg tgggcggcgc ccgggcgggc acggcggccg
    16321 ccgccgcgca gcgggtgctg atcccgcagg aggcgtacgt gttctcgggg acgctcgccg
    16381 acaacctggg ctatctgcgc gccgcccccg tcccggagac ggagctgagg gcggccgcgg
    16441 aggcgctcgg catggaggga ctcgtccgcc gcgtgggcgg tttcgaggcc cccctcgccc
    16501 cggcggagct ctcggcgggg gagcggcagc agatcgccct ggcccgggcg tacctgtcgc
    16561 ccgcccccct ggccgtgctg gacgaggcga cctgtcacct cgaccccgtc gcggaggccc
    16621 gcgcggagcg ggccttcgcg cgccgcccgg gcggcaccct cgtcgtcatc gcgcaccggg
    16681 cggcatccgc ccgccgggcc ggccgcatcc tggtgatgga cggcgcggac acggcctgcg
    16741 gggagcacca cgaactgctg gcgcggtccc cgctctaccg cgacctcatg ggcgccgcgg
    16801 aatccatgga ccccgcgcac cccgcgcacc ccgcggcccc cgcaccccgc aacccctcac
    16861 acccaccccg ccacctgcga gatacggatc gcgtcgaccc ggttccgtgc cccggtcttg
    16921 cgggtgatgg cggccatgta gttgcgcacc gtcccgttgg acaggtggag gctgcgggcg
    16981 atctccccga cggacgcccc ctccgccgcg agtgacagga cgctcagctc gcgtctcgtc
    17041 aggggcatct ccgaggcctc caggaagccg aagccgagcg tctcgtcgat gtaccgctcg
    17101 ccgttcgcca catgccgtat cccttcgacg agccggtcgg gagaagcgtt tttgctcagg
    17161 taccccaggg ccttctcctc gtacgcccgg cgcaggggcc ccggccgtcc cgcgctggcc
    17221 agggcgagca gggccgccct gtcgtcgcgt gcgtcaccgt gcccggacag ctcccgcagg
    17281 ccgcccggcc cgccggcctc cgggctgtcc atgtccacca cgcacacgtg cggccgcagc
    17341 gagtccgaca tggccaccgc gcgttgccag gacgcggacg agacctccag gtccggttct
    17401 ctgccgatga gagccgccag cgccgctcgc agcagatagg tgtcatgcac cagtagcacc
    17461 cggatcacgg tccccgcctt cccgctcccc cgcgcagcga gtgctgcgcc ggacaccgac
    17521 gctcattcat accggcgtgt gccaccgctc cgggcgcgta taccggacat ggagggggcg
    17581 caagggcgca tgaattccgc cacgtgcgcc ccaagttcac tcgaaagcgc ccctcatgaa
    17641 tcgggtgccg ggggtagcgc gtcaggcctg ctgtggggta gtgagccgga tgagccggca
    17701 gacggtctcg atgtcgatcc gcacctgtgc gatcgaagcg cgccccgaga gccaggtgat
    17761 gagcgccgag tgccaggtgt gctcgatgac gcggacggcg gagagctgct cgggggaggg
    17821 cggcccggcc ggccccatgg cgtccaggat gatcgccgtg gtgagccggg agacggtgtc
    17881 gacctcggcg ctcaccgagc ggtcggcgaa ggtgagggcg cgcatcatcg catcggccag
    17941 atgcggttcg cgctgcatgg cgcggaaggc ccgcatcagg gtctgggcca cgcgcgcggc
    18001 cgggtcggcg tccgtgggcg ggcgcttgcg cagcgtcccg tgcagccgct gcagctggtc
    18061 ctgcatggtg gcgaccagca ggtggacctt ggaggggaag tagcggtaga gcgtgccgag
    18121 cgcgacgccc gccgcctcgg cgacctcgcg catctgcacg gcgtcgaagc cgccgcggct
    18181 cgcgagctcc gtggtggcct gcaggatccg gcggcggcgg gcctcctgac gctcggtcag
    18241 gggaaggctg ggcccggcga gcacggcccg cgcggtcggc gacttgggtt ccgtcgtcat
    18301 atgtcccatt ccgtggcaat ccatccaggg tgtccgtacg gcccggacgg cacagcatgg
    18361 caggggccgg gccgtggcgc gaatcacccg atccggtcct ggcgaccgcc tttccggccg
    18421 gtagattcga ggcttctgga cgacccagtc tgaaacttgt tctagattag cgcgaccggt
    18481 tacgctccgg ccggaacagc agccagaagg aggccggggg agtgaccgct gaggccactg
    18541 aggcagctct cgcacatgcg gcgcgcgagg cgcgcgcggg gcaggacgca cggaacgacg
    18601 gcctccggga cggggacggc gaccgccccc tgcggatcgc gctgctcacc tacaagggca
    18661 acccgttctg cggcggccag ggcgtctacg tccgccacct ctcccgcgaa ctcgcccgcc
    18721 tcgggcacag cgtcgaggtc atcggctccc agccgtaccc cgtcctcgac gagggcgtga
    18781 ccctcaccga gctcccgagc ctcgacctct accgccagcc ggacccgttc cgcacgcccg
    18841 gccgcgacga gtaccgcgac tggatcgacg cgctggaggt ctccaccatg tggacgggcg
    18901 gcttccccga gccgctcacc ttcagcctgc gcgcgcggcg ccatctcgcc gcgcagcgcg
    18961 gccggttcga tgtcgtccac gacaaccaga ccctgggcta cgggctcctc ggcggtcccg
    19021 acgcgatcgg cgcgccgctg gtgaccacca tccaccaccc catcaccgtc gaccggcagc
    19081 tcgacctcgc cgccgcggcg gactggaagc ggcgggcctc cgtgcgccgc tggtacggct
    19141 tcacccggat gcagaagcgg gtcgcccgcc ggctgccgtc cgtgctcacc gtctccggct
    19201 cctcgcgcca ggagatcgtc gaccacctcg gcgtccgggc cgagcgggtg cacgtggtgc
    19261 ccatcggcgc cgacaccgac ctgttctcgc ccgacccgtc cgtgcccgag gtcccgggcc
    19321 gcatcgtcac cacctccagc gcggacgtcc ccctcaaggg cctcatccac ctgatcgagg
    19381 cgctggccgt ggtccgccgc cgccacccgg acgcgcacct cgtggtcgtc ggcaagcgtg
    19441 ccgaggacgg gccgatcgcc acggcgatcc ggcgctgcgg gctggagggc gccgtcgagt
    19501 tcgtcaaggg catcaccgac gccgagctcg tcggcctcgt gcgctcggcg caggtcgcct
    19561 gcgtgccgtc gctgtacgag ggcttctcgc tgccggccgc cgaggccatg gccacgggga
    19621 cgccgctggc cgccaccacc ggcggtgcca taccggaggt cgcgggcccc gacggggaga
    19681 cctgcctggc cgtcccgccg ggcgactccg gagccctcgc ctccgccctg gaccggctcc
    19741 tcggcgatcc cggactccgc cgccgcctcg gtgccgcggg ccgcgaacgc gtcctctccc
    19801 gcttcacctg gcgcgaggcc gcgctcggca cggcccgcca ctaccgcgag gcgatcgccc
    19861 tcgcgggcgc ccggcccgcc ggacggcgag gctagtgcgg cccggcacca cgtcgcgggg
    19921 cccgtccgcc acggcaagcg accaccgtgg cgcggtccgg cggcgtccag ccggccgtca
    19981 cccgtacgca cccgtcaacc accccgtccc gccggccgaa ggcaaatacc cgtgctgacc
    20041 gtcgatttct cccgcttccc gctcgccgca ggcgaccgcg tcctcgacct gggctgcggc
    20101 gcgggccggc acgccttcga gtgttaccgg cgcggagcgc gcgtcgtcgc gctcgaccgc
    20161 aacggcgagg agatacgcga ggtcgccagg tggttcgccg ccatgaagga ggccggtgag
    20221 gccccggccg gggccaccgc caccgccatg gagggcgacg ccctggccct gcccttcccc
    20281 gacgacagct tcgacgtcgt catcatctcc gaggtcatgg agcacatccc ggacgacaag
    20341 ggcgtgctcg ccgagatggt ccgcgtcctg aagccgggcg gccggatcgc ggtcaccgtc
    20401 ccgcgctacg gcccggagaa gatctgctgg gcgctctcgg acgcctacca cgaggtcgag
    20461 ggcggccaca tccgcatcta ccgcggcgac gagctcctcg accggatgcg cgaggccggc
    20521 ctggagccgt acggcaccca ccacgcccac ggcctgcaca gcccctactg gtggctcaag
    20581 tgcgccttcg gcgtcgacaa cgacaaggcg ctgcccgtcc gcgcctacca caagctcctg
    20641 gtctgggaca tcatgaagaa gcccgtggcc acccgggtcg ccgagcaggc cctcaacccg
    20701 ctcatcggca agagcttcgt ggcgtacgcg accaagccgc acctgcccgc cggggcggag
    20761 gcgtgacctt cttcagccgc ggctccggcc gcaccgagcg cctcgtgctg cccggcgtcc
    20821 tgaccgccga gcaggtcacc ggcaccgtcg cgggcatcgc cgccgtccag cgcgaggacg
    20881 gcgccatccc ctggttccgc ggccaccacc tcgacccgtg ggaccacgtc gaggccgcca
    20941 tggccctcga cgccgccggc gagcacgggc gcgccgaggc cgcctaccgc tggctggccc
    21001 gccaccagaa tgccgacggc tcctggttcg ccgcctacgc cgacggcgcc gccgacgagc
    21061 ccaccgaccg ctcccgcgag tccaacttcg tcgcctacgt ggccgtgggc gtctggcacc
    21121 actacctcgc caccggcgac gacgccttcc tcgacagcat gtggccgacc gtctacgccg
    21181 ccgtcgagtt cgtcctggcg ctccagcagg ccggcgggca gatcggctgg aagcgcgagg
    21241 acgacggcac ccccgtcacc gacgcgctgc tgaccggttc ctcgtccatc caccaggcgc
    21301 tgcgctgcgc cctggccatc gccgagcacc gcgaggagcc gcagccggac tgggagctgg
    21361 ccacgggcct gctcgcgcac gcgatacgcc gccacccgga gcggttcctc gacaagggcc
    21421 gctactcgat ggactggtac taccccgtcc tcggcggcgc ggtcaccggc gtcgccgcca
    21481 aggagcgcat agaggagggc tgggaccgct tcgtggtgcc gggcctgggc gtgcgctgcg
    21541 tgctgcccaa cccgtgggtg acgggcggcg agagctgcga gctcgccctc gcgctgtggg
    21601 tgatggggga gtccgaccgc gcggtgcaga tcctgcagtg gatccagcac ctgcgggccg
    21661 aggacggcat gtactggacg ggctacgtct acgacgacga cgccgtctgg ccggaggagc
    21721 gcaccacgtg gacggcgggt tcgctgctgc tcgcggcggc cgcgctcggg ggcgacgagg
    21781 cgacgaccgc cgtgttcggc ggggagcggc tgccctccgg gctggagccg gactgctgcc
    21841 cctagcggcg caccctgaag gggcgaaccg gaatctgaac gtccgggctc gtccggggag
    21901 ttgtcagtgg gcggacctac agtgaggtca tgacgatgac gctcagccac gaccgctact
    21961 gttccgagat cctgcaccag accgagctgc tgcgcggcgc cctgggcgag ggcgccgacg
    22021 tgtcggtcac cgtgcccacc tgcccggagt ggacgctcgg gcagctcctg ctgcacgtgg
    22081 gccaggccca ccgcatggcc accgggctcg tgcgcgatca ggtcaaggag ttcgtgccgc
    22141 cgtccaccgc cgcccagggc ggccccgcgc ccgccccggg cgagccctcc gcggacgatc
    22201 tgcccgctct cgccgcatgg ctcggcgaag gcgccgaggc gctggtggcc gtcctgcgcg
    22261 aggcggggcc cgacagcccc gtgtggacct tctccgagga ccagcggtcc gtcttctggg
    22321 cccgccggat gacgcacgag accctcatgc accgcgccga cgccctgggc gccctgggcg
    22381 tccccttcac ggcggagccc gaagtggcgg ccgactgcgt cgacgagtgg ctggacatcc
    22441 tcaccttccc ggcggccgtc gcgttcaagc cgcgcctggc ggagctgccc ggccccggcc
    22501 gcaccctcca cctgcacgcc accgacaccc cggcggagct cgacgcggag tggttcatcg
    22561 acctcaccgg cgagggcgtc tcctggcgcc gggcccacga gaaggccgcc gtggccgtgc
    22621 gcggtccggt gaccgacctg ctgagcgtcc tcttccagcg ccttcccgcc gacagcgacc
    22681 gcgtcgaggt cctgggcgac cgcgagctgc tcgacttctg gctggatcgg gccgtcttct
    22741 gaggcccctg tcctccgtgc ttccggcccc cgcgaggcat gtcctgacag gccgtccaac
    22801 agtcggatga gagcatgacc gtatgaccgt tgtgcccaga tcccccgtgc ccaggtggct
    22861 gc
//
