LOCUS       NZ_LNBE01000003        35220 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_3, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000003
VERSION     NZ_LNBE01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2630732)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2277781
            Orig. end                         :: 2313001
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..35220
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="23"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..35220
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..35220
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:25220](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..25220)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(233..1069)
                     /locus_tag="AS857_RS15530"
     CDS             complement(233..1069)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039623.3"
                     /locus_tag="AS857_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5995 family protein"
                     /protein_id="WP_058043681.1"
                     /transl_table=11
                     /translation="MTAVGPSPAEKVAGVARGLADHVRRYDEMRDPRAVFAYAYYRLTS
                     SLAASLRTNALSFREPHWVADLSVSLASAYFTAITAIDAWLGEREQPPRRDAVVDRADL
                     PETIPQPWRDVYAASTARRSYVLEDVLFSMMAHMSYDLPLALRSLNARRSNHEHIGDFH
                     RMNELLAKCIDEVQDDLADRYCRGLRSLDRLFTRDDELLTNYGIRVVRGLAWFNCDRLL
                     DPASAAEATGSISRSTAALITRIRYPDDWKLRCGTRLLRLLIPSRRQWPLPGTALD"
     gene            complement(1066..1644)
                     /locus_tag="AS857_RS15535"
     CDS             complement(1066..1644)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_144440833.1"
                     /transl_table=11
                     /translation="MTTTAPSHVYYFEVGTGVRRGTFTFRVTSWQRFLRAREIGAKNRL
                     LVIVMCVSQWLTGASQLDSTIVAKPREGDFGEADNTVRLSKFGATLYLLQERYVLDPDG
                     RTIVVHADEQFGPVPRFLARTFTYPAEIREAGMASTYHMPLLGTAWTATYQVAADRRAL
                     AGELVCDWAKATEKAARVPAAGSTTGDRP"
     gene            1922..2278
                     /locus_tag="AS857_RS15540"
     CDS             1922..2278
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644969.1"
                     /locus_tag="AS857_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF805 domain-containing protein"
                     /protein_id="WP_058044172.1"
                     /transl_table=11
                     /translation="MHWYVDVLKKYATFSGRASRPEFWMFTLVSLVISIVLAVIDALLG
                     TGMIIETVYDVAVFLPSLAVSVRRLHDIDRSGWWVLIGLIPIIGLIVLIVFWATAGKPR
                     ENAYGPNPQEVPAS"
     misc_feature    complement(1944..1953)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            complement(2457..2585)
                     /locus_tag="AS857_RS41915"
     CDS             complement(2457..2585)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS41915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275477362.1"
                     /transl_table=11
                     /translation="MPEQEQEAALSRIRAFLASRPETARGEFTLPMLTGVLRVRQL"
     gene            2903..3361
                     /locus_tag="AS857_RS15550"
     CDS             2903..3361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521623.1"
                     /locus_tag="AS857_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_058043684.1"
                     /transl_table=11
                     /translation="MSDIYELQLALDLPDTLPETDVAVLRWHMSDEGGGADHDEQDGEA
                     EGPETYPLLASRGPAWRIGGALVGELCRGPGGWALTARQEVHPDEFPALEALLTWLAAR
                     TSTPGPIGHLRFYESAVPDVLMTDGQVPCRMSLHPSVAVEAELLPGAE"
     gene            3414..4394
                     /locus_tag="AS857_RS15555"
     CDS             3414..4394
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245699853.1"
                     /transl_table=11
                     /translation="MHGRLLVVAALVPLPADGKPHCSAGAAGTSPSQPASAAGHRDFPH
                     TALGDGDKVDLGGLILRALATPGHTDEHLSFLLLDGSRELGVFTGGSLIVGSAARTDLQ
                     GADRAEELARAQYRSLRRLAELPDATEVWPTHGAGSFCSAPPGTERTTTIGAQKRANDL
                     LAVPDEDAFVARLLGSYPAYFARLAELNRRGPALLTGTPDLKPLTPARVRALLADDAYL
                     VDARPATEFAAGQPPRCRAHRARCPGRRRPGGTRRRGGHVRARRECDDRRQPPRPPRQP
                     GPCGAGRRRPGLREGDRSPSGTRPVTTPPPPPRTGSGPPGRPPSS"
     gene            complement(4494..5198)
                     /locus_tag="AS857_RS15560"
     CDS             complement(4494..5198)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474317.1"
                     /locus_tag="AS857_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5710 domain-containing protein"
                     /protein_id="WP_058043686.1"
                     /transl_table=11
                     /translation="MVERIWLDVPYAQKDEAKRAGARWDPAAKRWYAPRAGMTALAPWA
                     PAPDVPDLLPGEDRTLGSGLFVDLVPSSCWFTNVRSCVTQQDWERLRRMITRRAGMRCE
                     ACGAGEDRHAKRWLEAHERWVYDGARRVQTLKRLICLCTDCHTVTHFGYAQVRGLEAQA
                     FAHLVKVTGVTPDRARRHVDAAFALWQQRSATTWSLDLSILTGAGITVTPPPDARDRRG
                     IAATTLASEGQV"
     gene            complement(5421..5606)
                     /locus_tag="AS857_RS15565"
     CDS             complement(5421..5606)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387108.1"
                     /locus_tag="AS857_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1737 domain-containing protein"
                     /protein_id="WP_058043687.1"
                     /transl_table=11
                     /translation="MNTPPDGLPIYRVLTGPDDARFCQRVSEAIGLGYELHEGPAVTFN
                     GESVIVAQALVWPAQP"
     gene            complement(5701..6039)
                     /locus_tag="AS857_RS15570"
     CDS             complement(5701..6039)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245699854.1"
                     /transl_table=11
                     /translation="MAPPTESGEALLPDLTALFTALAATSAPGAVPLTPLAEPWQVQYQ
                     GRFRRHTRPAPGVWTAETVGCPKCGGKDGPWTVTCDWRQATLGCACGVVSREHGLSLSE
                     IWLVLPET"
     gene            complement(6193..7368)
                     /locus_tag="AS857_RS15575"
     CDS             complement(6193..7368)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990273.1"
                     /locus_tag="AS857_RS15575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_058043688.1"
                     /transl_table=11
                     /translation="MATNALPRTLITLALAGTVAAAAVAPASAAPRATSRPSPPSAHSA
                     TQDALDAITRAGTPGVLARVDRAGESWHGTSGVADLRTGRPRLPQDRFRIGSLTKPFIA
                     TVLLQLASEPEHGLSTDDTVDKWLPGLVRGHGNDGRRITLRQLLQHTSGLYDYIDDDGL
                     RAKFTGKAFFTHRYDGATPEELVRIGLAHKPLFAPGKGWSYSNTNYILAGMVIEKATGH
                     SYGSEVEQRIIRPLGLRGTTVPGSSPSVPGPHGRHYSKLYVDDPAARIYDVTDFNPSFS
                     GASGEMISTARDLNAFIRALLGGELLPPAQQKEMFTGHDLGGGRSYGLGIRSQTLTACG
                     VQVWGHSSEITGSLTRTAATADGEHVVTINRNGDWGDPALEQAALEAEFCR"
     misc_feature    complement(7351..7353)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7699..8250
                     /locus_tag="AS857_RS15580"
     CDS             7699..8250
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676823.1"
                     /locus_tag="AS857_RS15580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_245699855.1"
                     /transl_table=11
                     /translation="MPTARTAVAWMPPQELWPAIQEIRWEHDPQVRRWPPHVNLLFGFV
                     PEEEFVRAVPLLAAGAAENEAFTARLSGVRYFRHRHYATVWLDPAAAGPAPWARLQQAL
                     GSRFPLCRGRGGRFTPHLSLGRTQEPRQLAAECAARLGALPAVVEEVVLLSRRGDGPMQ
                     PRAVIALGTGEVRRLPEYEL"
     gene            complement(8292..9536)
                     /locus_tag="AS857_RS15585"
     CDS             complement(8292..9536)
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548796.1"
                     /locus_tag="AS857_RS15585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase"
                     /protein_id="WP_058043690.1"
                     /transl_table=11
                     /translation="MSTLPRDLLEAVTTLYLDLHAHPELSGEESRTAACFADWLTRAGY
                     RVTSGVGGHGVVALLENGEGPLVVVRAELDALPVQERTGLPYASRVNVPVPVMHACGHD
                     LHLAAAAGAASVLAGELGLWRGTVMVVGQPAEETLSGAQAMLDDGLHDRFGRPDAVLAQ
                     HAAPLPAGMVAHGAGPMTAGSVSLDVVVHGRGGHAATPHLAVDPVVTAAAVVLRLQTVV
                     AAETAPAEQVVLTVGRLQAGTRGNIIPDRAELGLTVRGFSDAALDRVVTAVHRIVRAEC
                     DASGCPVPPEISVASRSPVNHPDPQLTAAVRDAHAAAFGEARVTGWPPSMATEDFPLLA
                     PDGVPTVYWMLGTAGPRQWAAAPGTTAAEKLAALPPNHSPLFAPSPRLALPTGITAMVT
                     AARAALGRHSPGSPS"
     gene            9720..9896
                     /locus_tag="AS857_RS15590"
     CDS             9720..9896
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968635.1"
                     /locus_tag="AS857_RS15590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_058043691.1"
                     /transl_table=11
                     /translation="MAQQAELATLAQEILELESETFEISDYSDASEVVLAGSTSSSSTS
                     TCSSTTSTTSCSA"
     gene            complement(10001..12001)
                     /locus_tag="AS857_RS15595"
     CDS             complement(10001..12001)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515647.1"
                     /locus_tag="AS857_RS15595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_058043692.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-74, bitscore: 247.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 5.1e-100, bitscore:
                     332.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAATTTTTTTTTAALVTDPMAAASRRLQQALSERFRASGRQVA
                     DHPAPVVVPVGAADAFRPAADPYGTLRPRATVHLTAQAALIGPWGAQGDIPAACGGCLA
                     RRWQRLRSRSERDALEVGTGMTGAGLWPVLPDHAVDAIWTVYEAVLLSGRPAGAGRPDG
                     EWHTSADLPLPQVTRVDLATLRLTTLPLLGDPLCPACGPLPGPYTPPELVTRPKPGPGA
                     SRLRPAGSYPLPQGALANPVCGALGEGTWLNVASPTTSPVAGSVFVRTYAGLSDVTWSG
                     QANSFAASRTLAYLEGLERYAGIHRRHRGEPLVAAYDDVQDEAVDPRTCGTYAPEVYRT
                     DPMLAPFDPARPIPWVQGYSLRDDRTVLVPRRAVHYGAGLDSDNFVFESSNGCATGSCL
                     EEAVLFGLLELVERDAFLLGWYGRARLTGIDLASCRGGAVRAMADRAALQGYDVHAFDN
                     RVDLAVPVVTAVAVRRDGGPGTLSFAAGARLDPEEAVEAALSEVLTYLPHLDRQVAEHR
                     TALEAMADDFSLVRELTHHARLYGLPRMAQHAREYLEPESVRPLAELYGPWQRQRPATG
                     DLLDDLLLCRDELTGAGFDVIVVDQTSPEQERMGLCTVSTVVPGLVPIDFGWDRQRVLG
                     MDRLRTAFRRAGWRSTDLREEEIRRVPHPFP"
     gene            complement(11998..12753)
                     /locus_tag="AS857_RS15600"
     CDS             complement(11998..12753)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609025.1"
                     /locus_tag="AS857_RS15600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_058043693.1"
                     /transl_table=11
                     /translation="MSAYTALTGASYRAAVRDRTTVFFTFAFPLIFLVVFGLIFRGKTV
                     EQSGRGYIDYIAPGVLSWGVGNAAVFGVAFTLMQWRRDDLLRLIRLTPTPLGSVLASRY
                     VIALAIGAVQAVLFIGVALLPVFGLHVDATWPWALPVLVSGITAFLAIGMVIGSRADTP
                     EAVAAVANCVMVPMAFLSGAFYPLDAMPSWLQTAARVLPLHYLNDGISRAVSGRADLAS
                     TAVACGGLALFALVFGGIAVKTFRWSNAS"
     gene            complement(12750..13694)
                     /locus_tag="AS857_RS15605"
     CDS             complement(12750..13694)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845447.1"
                     /locus_tag="AS857_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058043694.1"
                     /transl_table=11
                     /translation="MTDTKPSARAAAPALVLDGVRKRYGDKQAVDGISLTVERGEFFGV
                     LGPNGAGKTTLVEIMEGLRKADAGSVSVLGVSPWPRNLALLPRMGVQTQTSAFFTRLTA
                     REHLATVAALYGSGPARVEHTLALVGLAEQGDVRVDVLSGGQRQRLAIASALVHGPELI
                     FLDEPTAALDPQARRVLWQVLRALKSEGRTIVYTTHHLDEAEALCDRVAIIVAGRVVAL
                     DSPDRLVGAAQAPTRLLVPADRITVERAQAFEGADRVTAEGGSVVIETRSAGPLLAALG
                     ADVGLDGIRTRTATLEDVYLELTGELAGTEQHA"
     gene            complement(13701..15056)
                     /locus_tag="AS857_RS15610"
     CDS             complement(13701..15056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968630.1"
                     /locus_tag="AS857_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_063804261.1"
                     /transl_table=11
                     /translation="MTPRTSPSTPPPTHHRLLEQRPALRPEILRSSALRRGPAVVHLVK
                     DPRSGQSFEVGVKEHFLMSRLDGSRTLGEVGEEYAARFGRRLGEAHWQQLLKLLWERRL
                     LEGAGGVESAGSAGGAGSSEPAVSGQPTGAAPRKLVTGTLLKGTLRLAADATATTDRLY
                     RAVGFALAPVVVVPVLLLVLGMETYVAVHAGAFLDDAVRLFRQPGALLAAFTLLWASTA
                     LHELAHGVVARHFGGTVGEIGLRWHLPMVFMYCTVENYPYLPTRRARVATAAAGTVMNL
                     AFLLPFWLLWSLLPGDDAARGPLAGLLFTGSVLALTNLVPLPPLDGYKMLGQALGMADY
                     ATESRRFLRLLGARAVRRGDGVAAYPRSARIAYTAYGLGAVLLVGGSGAGLVLLSHHLA
                     GNRYGLWAAVVPALLVAALVAVTGPWARRGDRHPQTSSAPRNATRNTPRKKS"
     gene            complement(15053..16105)
                     /locus_tag="AS857_RS15615"
     CDS             complement(15053..16105)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515651.1"
                     /locus_tag="AS857_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_058043695.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.2e-101,
                     bitscore: 336.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPALATPGAWQALHIHYAANPQPLMTRCVGPLLAELTAEGLLA
                     GHFFINYWLEGPHVRLRLKPSSEAVADEVAERAEQAVTAFLRERPALYEVDSSGFLNEF
                     YNTLFELEFPEDERGGFLDADGRMRLRPNNTVSREPYEPEYGKYGGPAGVELAEWHFRH
                     SSDLVIEAVRTMNLHLRTVRLGTSAQLMMVMAGTFLPGRAELAEYLDRYHVFWQKAFSG
                     TNFIGSDEYDRAYAAMGPAPARRFGAVLGALAGEAADGLTELPRFLRGWAEHCAELRDR
                     ATALAVRGDLVFRSWDGTADEQVTDPAVALPLLLSPYMHMTNNRLHVTIRDEAYLSYVL
                     GRALREADPR"
     gene            complement(16102..18906)
                     /locus_tag="AS857_RS15620"
     CDS             complement(16102..18906)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845450.1"
                     /locus_tag="AS857_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_058043696.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.1e-49, bitscore:
                     163.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRVAGLPVESVQALRCPATVRWAERVLREEERLRSRGAALSDRL
                     HPLVKAAEDDGARRLLLRLRRDVFNGRLPGAPEQALALLAADDTGAAEDAGRWVRDRRA
                     LDGLLTEGAPLLAAETTRTRTALRGLLGEERLRLGLLLASPELEERLDAYIGADPGRRP
                     DKRLRKAERSALAYLYRTACKTSPFSTFTAVALGRFTEGADGGEAGDGGEGTESDPGIV
                     RVPEEWTGHPRLNVVVLARLAELMAADPGRRGDLPVTLSSGWRHDEDRVRYVRRSVTAG
                     DDGAAVTFDAARDRLFFLRRSDTLEKLLALFGERPQLRYRDLARWLAEERGAGPDECER
                     YLTALLDLGMVQIPCLRTDVHDADPLRAFRDALQALDRPWAARLAEALEKPIDCVGRYA
                     AAGPKLRRELLSELRQALTGIQRELGAAEPTLPRTLLYEDVRAGGNEEGDTGVVCDLRP
                     WSAPVTAAGEGPLETLCSLERILPAFDLTLPQRITLKGFFVARYGSGGRCEDLLKLVHD
                     FHEDFYDQYLTFTARRKPFDAQGDYVPEPNWLGLPGITAVDAARREWTSRMRRLWDTAR
                     GAEEIRVHPETVEAVAGRLTGVAPRFAPQSHFLQLVRRDGEPLAVLNQSYGGFAFPFSR
                     FTHCFDGEGSEGSEGSENGGIGGGALSARIRRTAAAVPPEGAVFAEITGGAATSNLNLH
                     GRLTDYRIVCPGEDGGVPEGSRIALDDLYLEHDVQADRLVLRSRRLDREVVPVYLGYLV
                     PLALPEIPRTLLLLSPTSMAPLDVWGGVPEGEPDDGVTSRPRVRCGGLVLSRRSWTAPA
                     AALPALGSGSAGGGDADRFLQWQRWRVRHGLPHRVFATVTPTAAAPGADRAKPQYVDFD
                     SWLSLTALEGLLKDPAGRVVLREALPGEDELHAVSARGTHMAELAVETLRTPRHDREGT
                     GAPT"
     gene            complement(19033..20697)
                     /locus_tag="AS857_RS15625"
     CDS             complement(19033..20697)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059793.1"
                     /locus_tag="AS857_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase family protein"
                     /protein_id="WP_058043697.1"
                     /sec_met_domain="PF00881 (E-value: 1.6e-13, bitscore: 48.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFAHEYATAIMHRGRIPMEPVGFVPDWSDRPRKGKFYPGAESFP
                     LPEGDDAGPAATVQEGVFGGAGRQEGCFSLPLMGGMLLDSYGRTGRRLGVQANTDLPSL
                     PLYTDANWSRGTASGGGLYPATVYWVNGPGGPLAPGVHHYSTTHHAMQRLLTGDVSAEV
                     REAAGLGPDVATDQFLVLGVKFWQNAFKYNSFCMHAVSMDVGALLQTWRMWARARGLRI
                     EPALWFDEERIARLLGLDVLDEGVFAVVPLTWERTTAPAATGRATGPAPRVRRTESERS
                     RRVIPFETVRRIQAATLENATARPEPGALAPAAVSPEPPSSAPEAAPVALPEPAPLSMG
                     VREALRRRRSSFGRFDARRPLAADQLAATLAAAASASVGSDATGPDRQDGPDRQAWPDG
                     QAWPDTPRLARLYVFVNHVEGIAPGAYAYEPGSAHGLRLVKPGPPGDFLQRNYFLSNYN
                     LEQAAAVVVPAVRTAAVLDAAGDRGYRLVNATVGAVAQTFYTAATALGVGSGVALGFDT
                     VSFVEELELAESGEAPLLIMLVGHERPGSADFRYEIA"
     gene            complement(20765..22837)
                     /locus_tag="AS857_RS15630"
     CDS             complement(20765..22837)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890997.1"
                     /locus_tag="AS857_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_173864730.1"
                     /sec_met_domain="TIGR03604 (E-value: 7e-93, bitscore:
                     308.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.6e-80, bitscore: 268.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTDTGTAHDPGVARPSFPDTARPSDTARPAGAAGVPSIAADGT
                     GLSPAPPEWEHACRDIAALLRASPAGTGAPTEVAPLGVRDELAQEALPQGDLAPRVHLY
                     GHHALIGPFPRPDRAHRDGGVPCPRCLARRWQSVRGRALRDALELGSDTRAAGRPPYAL
                     PFLTDAMAALIAARTADSPATGAADEDGPFPAVHLLDLETLHVSRHLIVPDAECPDCGR
                     RVPDSAQAAELTLQPAPKHRPGSFRVRAVSQYELPVRAFANPVCGALGPGVVHDVASAS
                     TSATVGCFELRSGEYLRETFWGGHADSYADSERIGVLEGLERAAGMRARGRSPQVRASL
                     AALGDDALDPRECGLYAEEFHRANPRVVPFSPDREIPWVWGYSLRDHRPLLVPEILTYY
                     GTPGLENRFVQESSNGCASGGSVEEAVHHGLMEVIERDAFLLAWYGRAALPEIDPQTST
                     DPRTRQMVDRLAMYGYEARFFDTRITFPVPVVTAVAVRTDGGTGTLCFGAGAGLDPEAA
                     LAGGLCEIATDAVNIRGRAERDGTRLRAMAADFDKVLALHDHPLVYGLPEMAPHASFLL
                     GHRGPKLPMAELYAPGERMLPVAEDLRDDVERCVAVVTGAGFDVIVVDQTLPEQRDLGL
                     HTVCVIVPGLLPIDFGWQRQRALRMPRMRTALYAAGLRERELRADELNPAPHPFP"
     gene            complement(22824..25220)
                     /locus_tag="AS857_RS15635"
     CDS             complement(22824..25220)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609032.1"
                     /locus_tag="AS857_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_063804262.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4.5e-17,
                     bitscore: 58.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2.4e-11, bitscore: 40.4, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 2.8e-14, bitscore: 50.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEAYEEIAGTRPRIRRDVLFTRTPDGVLFHNAHGGFHVNSPSAY
                     RFATLLVPHLNGKHRVADLCEGLGDGQRAMVGSLVSTLYEREFARDTPAPGTSAPPAFS
                     PEVAERFAPQIAYADHYADDAERRFHDFRTARVAVLGDDAVAGWCALGLVRNGIASVGH
                     RAGTEDRFARAHEEAEGLRAAGCPVSLEPIEATGSAAGQAADGPVTVSWSDLAAYDIVV
                     VTGGTDGPRPLFRLLEAGVPEGKSLVPAAMFGSRAVVGPLMTHGSTGCWACAVLRLGAH
                     GDAAAAADLWSGICLPAAGDPLAQQPGRSLSAMIGNLLGYEVFRLTTGALPAETLGQVI
                     IQDTESFDVVAEPLLAHPRCPFCRTTGAAAPEPAAPAAAPVALPDVPAPAPAITTTIPA
                     GPNPTGIDSTGIAPTSIDSDALLAELNSRQILVRPHTGVFERFTDEPWTQTPLKAGTVR
                     LPLGHGRSREIAAFDLHTVAGARLTALDTAACVYAEHVVPLGGVLPGDAVRPDRAQGRL
                     RVLGPDSLTVASGLPARAEDVTAWVRASSLTGAGPALVPAGAVRTFGPYNHDRLHTPTS
                     AGTGAGRTTPEATAQGLLSALCHDALERALRRTGGAALIAPDAHGDDPELTFLVSSARN
                     LGIERYELLDLGETERSSAHVLFARALLPHSGTWAWAVAGATDRRQAAVTALRDLLGQE
                     QLGRELAGADRSGRASSVDLGDPLLGDLAPETLTTMGTSAGRLDASDATTYATVLDRLR
                     AAGRDALVVPTGSADLLAGGISTVRVLLTRDGSAGNAPEGSDDSH"
     aSDomain        complement(24945..25190)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AS857_RS15635_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.00E-13"
                     /identifier="RREFam011.1"
                     /label="AS857_RS15635"
                     /locus_tag="AS857_RS15635"
                     /protein_end="92"
                     /protein_start="10"
                     /score="40.4"
                     /tool="antismash"
                     /translation="TRPRIRRDVLFTRTPDGVLFHNAHGGFHVNSPSAYRFATLLVPHL
                     NGKHRVADLCEGLGDGQRAMVGSLVSTLYEREFARDT"
     aSDomain        complement(24957..25190)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AS857_RS15635_Thiopeptide_F_RRE.1"
                     /evalue="5.60E-19"
                     /identifier="RREFam004.1"
                     /label="AS857_RS15635"
                     /locus_tag="AS857_RS15635"
                     /protein_end="88"
                     /protein_start="10"
                     /score="58.9"
                     /tool="antismash"
                     /translation="TRPRIRRDVLFTRTPDGVLFHNAHGGFHVNSPSAYRFATLLVPHL
                     NGKHRVADLCEGLGDGQRAMVGSLVSTLYEREF"
     misc_feature    25257..25266
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            complement(25324..27252)
                     /locus_tag="AS857_RS15640"
     CDS             complement(25324..27252)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845454.1"
                     /locus_tag="AS857_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_058043698.1"
                     /transl_table=11
                     /translation="MRFQVLGPLRIADGPEVVVLPPSKPTILLASLLLRPDAVVPADFL
                     RQAIWGDDEPSSAKAALHTCVLRLRKTFIKYGIAEAVIESVPGGYRVVVEDGALDLVRF
                     RELRAGARAAQDPEAELCLLREALALWQGAPLSNVPSDFLRRGELPGLVEERLSVVERA
                     CDIELLLGRCGQALVELWAASRAHPGHERFREQLIEALYRSGRKADALAEYRDVKRYLR
                     EELGVDPGPALQRLELRILRGDVLGPPPLAVPVRESARTGRDVAGGNPAARPAAVTAPP
                     FPSTSTPSPSSAPTPASASASASGPILTPPPTLPITAVSSFTGRATEGAAIAARLTADR
                     SGPALVVVSGAPGIGKTALALHVAQLVGHHFPDGRFAVRMTRTDGTPRTSAEVAAELQG
                     MAAAPGPASACGADRRVLLILDDVADPALVRPLLPTGTGSAAVLTSRLGLAGLVAAHGG
                     WATRLDALAEDESSQLLSAALGDVRAGAEPEAVRELAAACGHFPLALRIAAARLLTRPR
                     LAVADCVAWLREDPMRRLSLPDDPRMSVPRVLGDALQRLDPRLAEVFLRIGGAPPAPLS
                     VADAARLLGIPPVPAEEILEQLADAGLLEEEPAGRFRMHELLRTFARCATGYTGYQDGS
                     LALPSRQ"
     misc_feature    complement(27226..27228)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    27277..27295
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.67"
                     /tool="antismash"
     misc_feature    complement(27322..27335)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 19.13"
                     /tool="antismash"
     gene            27603..28445
                     /locus_tag="AS857_RS15645"
     CDS             27603..28445
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.4"
                     /locus_tag="AS857_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_079110368.1"
                     /transl_table=11
                     /translation="MENQDQSPERPATVTCAPHAQSVSRLLRAWRERVDRRRIPELRRW
                     GHRSGTRMSQADVARLTGVSEGWYRALETGAPREFSDAFLLRVAEALQLSETETLTLFL
                     GVSGRRPPVSGTHDGLPTAAPATVALLEHQAPHPAYLSDAAWNILAANSPMTEWFPFAL
                     GPRPNLMRWALTSAEAREQILDWEDTCARTYLPMLRVASHGAPKNAEIRALIDEILATN
                     GTCRRIWAEQHAVVEHPGGHRLRLRLPCHGGVETQVTSHVLVPAEQPDVRFVIVTTVD"
     gene            28662..29303
                     /locus_tag="AS857_RS15650"
     CDS             28662..29303
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497475.1"
                     /locus_tag="AS857_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_058043700.1"
                     /transl_table=11
                     /translation="MAGDLSEAADSSLRRHVSEQRISHRDRDQAVEILRVAAGDGRLTI
                     AELDERIEAAMAARTASDLAVLTADLPLEGMPPQAREVIRIDQRFGEGKRTGRWLVPRR
                     MEIRLMFSDLKLDFTEAVITHDTLHIEVDLRIGGNLTLVTGPGIVVDADDVTYSRGEIK
                     VRPVAGPEAPVRLRVVLAGRSTGGDIVARPPRGTPRQWLRRKPRAAGNAR"
     misc_feature    29486..29497
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     gene            29679..30179
                     /locus_tag="AS857_RS15655"
     CDS             29679..30179
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_144440834.1"
                     /transl_table=11
                     /translation="MALSVPSSAAHAAVGAQSGPVEPGVPYYLVATKLDRGITAGRASE
                     YGDLVHYTERAGDQGTPVVFEKDSNTTWGEGYQIRLQRRGSATMLCHTYHRWIALMDSC
                     RQNPWMLEPSGDTFRLKTRWDGSYLYLAASPTFPSDKTLYWKDRYGSDDLNVTEFKLVK
                     APR"
     gene            complement(30364..31110)
                     /locus_tag="AS857_RS15660"
     CDS             complement(30364..31110)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_144440835.1"
                     /transl_table=11
                     /translation="MHVRPRRVVLAALAASSLLLLTACNGDSGSSSSSEAKKGKASAAP
                     SVPAYITAAQAEQALVALEDLPAGWKVEANTSMDKSQGAEEDAVTGAKPECAPITSVLN
                     SGRLEEDYKANHERVFTKEGDQILLAQDVSGYPRPQAEKAMAGLRNAVEKCATFTGKQN
                     GKKATVTVKKTADQQKYGDESVTYTVKVVAGDMQMDFDMGTMRSHGAITTILNNYSDHG
                     DRGKEAFSKALAKAAEKLTAAAAKTA"
     gene            31340..32215
                     /locus_tag="AS857_RS15665"
     CDS             31340..32215
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093410.1"
                     /locus_tag="AS857_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_058043703.1"
                     /transl_table=11
                     /translation="MRRHEHVGPMALRAMQDLATRTFPATGYRHIGDLTWNWCLSLGRV
                     NECPTAVWTEGGRTLAWGWLDLPDSLMLQVDPDHPELAHDVLAWAEQAAPGPLHVEVAG
                     TESHLAKALEQRGYTQAVDGPFMACLDRSLTELPDVPRLPDGYAIRTQHDDTDVAGRAA
                     AHRAAFGSTRVTTERHARMRDAWPYRPELDLGVTTPTGDVVAYCQGWYDEVNATGAFEP
                     VGTHPDHRRLGLARAVCTAVLHAFARVGGRRAIVRSRGDAAYPVPKRLYESMGFTTYTR
                     THTFVGRPSD"
     gene            complement(32283..33521)
                     /locus_tag="AS857_RS15670"
     CDS             complement(32283..33521)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025030.4"
                     /locus_tag="AS857_RS15670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_058043704.1"
                     /transl_table=11
                     /translation="MTSPEHPLLTAVRNGDTQAVAALLQEEYGTAHARGPHVAAALRLA
                     ADALDHRVLDALLKLADLDALDLDGVDADGRTPLLRAVDRGAHDIATALHFAGADPRVT
                     DREGRDALALARHWHTTGTGAGVRRRTVRDGNGEICRELMIGEQTVRDGHTAILTHLES
                     CCGIATPFTELLDRAMAEPEVDHPVWGEAVVAAAGRKGPALPPVWDAAAALRHHPDPLA
                     RYFGADVLRCINLYDESGEDEEPPFDTPLVDLFLTWVEQEQDPRVMRPLAAGLADAMDS
                     RAKRTLPALTRYPDPQVRSWAVGGLGRQVQQANTDALAAVLACTRDTDAQVREAACRTL
                     LRARADDPAPCDALAACLSDSEEAVRVTAAVQLALRDDHRGDALLDGLDGTVDRTSPYY
                     WLLYDVWRHRRDR"
     misc_feature    complement(34566..34580)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    34568..34582
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.26"
                     /tool="antismash"
ORIGIN
        1 caccctgcgc atcagggccg cggcctcggc aggctcatca tggccgcgct caccgaggaa
       61 ctggagcgcc gggcgcccgc caccgcttac gtctctctga tcgcggacgg ccccgcacgc
      121 ttcctctacg agaagttcgg cttcgcagat accgccacgc acgactcgat cggcatgtac
      181 cgcatgatgg gcgagagctg aagggcgcgg gccggccgga gcccatgccg cgtcagtcga
      241 gggccgtgcc cggtaggggc cactgcctgc gggaagggat cagcaggcgc aggaggcggg
      301 tgccgcagcg cagcttccag tcgtccgggt acctgatgcg tgtgatgagg gcagccgtgg
      361 acctgctgat ggagcccgtc gcctcggcgg ccgacgccgg gtccaggagc cggtcgcagt
      421 tgaaccaggc gagaccccgg acgacgcgga tgccgtagtt cgtcaggagc tcgtcgtcgc
      481 gggtgaacag ccggtcaagc gagcgcagac cgcggcagta ccggtcggcc aggtcgtcct
      541 gcacctcgtc gatgcacttc gcgagcagct cgttcatccg gtggaagtcg ccgatgtgct
      601 cgtggttgct ccgtcgggcg ttcagggacc gcaaggcgag gggcaggtcg taggacatgt
      661 gcgccatcat ggagaagagc acgtcctcga ggacgtagga ccgccgggcg gtggaggcgg
      721 cgtatacgtc gcgccatggc tgcggaatgg tctccggcag gtccgcccgg tcgacgacgg
      781 cgtcccggcg cggcggctgt tcccgttccc cgagccaggc gtcgatggcc gttatggccg
      841 tgaagtaggc ggatgcgagg gagacggaca ggtcggcgac ccagtgcggc tcccggaacg
      901 agagcgcgtt cgtgcgcagg ctcgcggcca ggctggaggt gagccggtag taggcgtagg
      961 cgaacaccgc acgggggtcg cgcatttcgt cgtatcgcct cacgtggtcc gcgaggccgc
     1021 gggccacgcc tgcgaccttt tcggcggggg aggggcccac ggccgtcatg ggcggtctcc
     1081 ggtggtgctg ccggctgcag ggacccgggc ggctttctcc gtggccttcg cccagtcgca
     1141 caccagctcc ccggcgagtg cgcgccggtc ggctgccacc tggtaggtcg cggtccaggc
     1201 ggttcccagc agaggcatgt ggtaggtgga cgccatgccc gcctcacgga tctctgcagg
     1261 gtaggtgaag gtccgtgcga ggaacctcgg cacggggccg aattgctcgt ccgcgtgcac
     1321 gacgatcgtg cggccgtcgg ggtcgaggac gtagcgctcc tgcaacaggt agagggtcgc
     1381 accgaatttc gagagcctga ccgtgttgtc ggcctctccg aaatctccct cgcgcggctt
     1441 ggccacgatg gtggagtcca gctgggacgc tccggtgagc cactgtgaca cgcacatgac
     1501 gatgacgagc agccggttct tcgcaccgat ctcccgggcg cgcaggaaac gctgccacga
     1561 ggtgacgcgg aaggtgaacg tccctcgccg gactcccgtc cccacctcga agtagtagac
     1621 gtgactgggt gctgtggttg tcacgctgtg cagcgtaatg ccgtggcccc tgctcaccgg
     1681 ggaaggccgg ccccgtgttg ccccaggcgc ttcctgcggg cggagcggac ggtcgggcgt
     1741 gcggagcgaa caatggacgg gggctcgcgt aggcccaggc gcgcacgcag gagcccggga
     1801 gcactctgct ggcgctgttg cccgcatcct cacgaccgtt gaccgacctg tttgagccac
     1861 ctacgttcga gatgaggcct ggtccgtgcg gacgggccag ccgcggctct tgggggcgca
     1921 ggtgcactgg tatgtggatg tgctcaagaa atacgcgaca ttcagcggac gggcgagccg
     1981 ccccgagttc tggatgttca ccctggtcag ccttgtcatc agcatcgtgc tggccgtcat
     2041 cgacgctctg ctcggcacgg gcatgatcat cgaaaccgtc tacgacgtcg ccgtgttcct
     2101 tcccagcctc gctgtcagcg tccggcgcct gcacgacatc gaccggtcgg gctggtgggt
     2161 actgattggc ctgattccga tcatcggtct catcgtcctg atcgtgttct gggccacggc
     2221 cggcaagccg cgggagaacg cctacggccc gaacccacag gaggttccgg cctcctgagg
     2281 gccagcctcg cactttcatg aaacgggctg tccggcgggc gggcggtcgg ctcagtgaaa
     2341 agtgcctctg accagtgagt atgagagttg tcgagacgct cgttcacgca ccagccggag
     2401 gcacttctca ggtgagtaag ccgtcaggct cgggtgtcgg cgtgatgcgt cacgcttcac
     2461 agctgccgga cgcgcagcac gccggtcagc atcgggagag tgaactcgcc gcgggcggtc
     2521 tccggtctac tcgcgaggaa tgcgcggatc cggctcagcg cggcctcttg ttcctgttcc
     2581 ggcatgacca gtaccccagc gcgtgtcgcg atggtcgcga ccaaggaggc ggcggtcgcc
     2641 accatggtcg ccgctcccgt cagtatgcga cgcccaatac cctttgtcgc aggcatagga
     2701 tccccccgtc ttcggctgcc caccccctgt gaggcagcat cgacgccggg acagacacgc
     2761 tgcgggcagg cccgggttcc ctctctccga agcgcgggct cgccagccgg cgcctccgca
     2821 ctcaccgcac gccccggagc cgcccctagg gcttgaccgg gggccgtgcc ctccgccgcc
     2881 tggtgcgccc tattcttccg gcgtgagtga catatacgaa ctgcaactgg ccctcgacct
     2941 cccggacacc cttccggaga cggacgtggc agtgctccgc tggcacatgt ccgacgaggg
     3001 cggcggcgcc gaccacgatg agcaggatgg ggaggcagaa ggccccgaga cgtaccctct
     3061 gcttgcttcc cggggcccgg catggcgcat cggcggggct ctggtcggtg aactctgccg
     3121 aggcccggga ggctgggccc tcaccgcgcg ccaggaggtg caccccgacg agttccccgc
     3181 cctcgaggcc cttctgacgt ggctggccgc gcggacgtcg accccgggcc ccatagggca
     3241 cctgcgtttc tacgagtccg cggtgcccga cgtcctgatg acggacgggc aggtgccctg
     3301 ccgcatgagc ctgcacccat cggtagccgt cgaggccgaa ctgctgcccg gcgcggagta
     3361 gaacgcgccc ggcgcaccgg gcgcgcggcg gtcgaccagc tgccggcaca cccgtgcatg
     3421 gtcgcctgct ggtcgtcgcg gcgcttgtcc ctttgccggc cgacggcaag ccgcactgct
     3481 cggccggcgc cgccgggaca tccccttcac agccggcctc ggcagccggc caccgcgact
     3541 tcccccacac ggcactcggc gacggcgaca aggtggacct gggagggctg atcctgcgag
     3601 ccctcgccac acccggccac acggacgagc acctgtcctt cctgctcctc gacggttccc
     3661 gggaactcgg cgtgttcacc ggcgggtcac tgatcgtcgg ctctgccgca cgcaccgacc
     3721 tccagggcgc ggaccgggcc gaggagctgg cccgcgccca gtaccgctcg ctgcgccgcc
     3781 ttgccgagct gccggacgcg accgaggtgt ggcccaccca cggcgcgggg tcgttctgct
     3841 cggccccgcc cggaaccgag cggaccacca ccatcggcgc gcagaagcgg gcgaacgacc
     3901 tcctggccgt gccggacgag gacgcgttcg tcgcccgcct gctcggctcc taccccgcct
     3961 acttcgcccg cctcgccgaa ctcaaccgcc gcggccccgc cctcctgacc ggcacccccg
     4021 acctgaagcc gctcaccccg gcccgcgtcc gggccctgct cgccgacgac gcgtacctgg
     4081 tcgacgcccg cccggccacc gagttcgccg ccgggcagcc tccccggtgc cgcgcacacc
     4141 gagctcggtg ccctggccgc cgacggccag gaggtacgcg acggcgcggt ggtcatgtgc
     4201 gggcacggcg agagtgcgat gaccgccgcc agcctcctcg cccgccgagg cagccggggc
     4261 cttgcggtgc tggtcggcgg cgcccaggac tgcgtgaagg cgaccggtcg ccctctggaa
     4321 cgcgaccggt gaccaccccg cccccgccgc cacggacggg atccggcccg cctggtcgac
     4381 caccgtcatc atgaagaccg gccggcctca tcgacccggc ccgccgcggc ccggcgacgg
     4441 gcttcaacga cgcgccgcgg gcagtgccgc gtccggcata cggcgatgcg ccttcagacc
     4501 tggccttcgg aggccagggt cgtggcggcg atgccacggc ggtcgcgtgc gtccggcggc
     4561 ggtgtgacgg tgatgccggc tccggtgagg atgctcaggt ccaggctcca ggtcgtggcg
     4621 gagcgttgct gccacagcgc gaaggccgcg tcgacgtgcc gccgagcccg gtccggagtc
     4681 accccggtga ccttgacgag gtgggcgaag gcctgggcct cgaggccgcg gacctgggcg
     4741 tagccgaagt gcgtgacggt gtggcagtcg gtgcacaggc agatcagccg cttgagcgtc
     4801 tgcacgcggc gagccccgtc gtacacccac cgctcgtgcg cctccagcca cctcttggcg
     4861 tgccggtcct cgcctgctcc gcaggcctcg cagcgcatgc cggcccggcg ggtaatcatg
     4921 cgacgcagcc gttcccagtc ctgctgggtg acgcaggaac ggacgttggt gaaccagcag
     4981 ctgctgggca ccaggtcgac gaacagcccg ctgccgagcg tacggtcctc accgggcagc
     5041 agatcaggga cgtcgggggc cggcgcccac ggggcgaggg cggtcatccc cgcccggggc
     5101 gcgtaccagc gcttggcggc cggatcccag cgtgcccccg ccctcttcgc ctcgtccttc
     5161 tgtgcgtacg ggacgtccag ccatatacgc tcaaccactg tgcgcttccc tccccgttgg
     5221 cgacgcggca aacgctaccg gtccggccgg ccgcgtgttg gctgagcgct gtggcggcgc
     5281 tgctcactcg ccgaagtgtg cacgggacac cccggacagg gcaggatggg aagaggccgc
     5341 acaggcccag gtgtgcgcct caactcaccc gacccgtgcg gcccttctca cggtacgagc
     5401 cgattgcgac caccgtgccc ctacggctgt gccggccaga ccagagcctg ggcgacgatg
     5461 acgctctcac cgttgaaggt gacggcgggg ccttcgtgca gttcgtagcc aagtccgatc
     5521 gcttcgctca cacgttggca gaacctggcg tcgtccggtc cggtgaggac tcggtagatg
     5581 ggcaatccgt ctggtggtgt gttcatgagg agaaggatcc cagatgcacg catgcacgca
     5641 cccaccgagc cggctggccg gccggcacgg cccgaagccg gtcgctccca aggccgttgg
     5701 tcaggtctcc ggcagtacga gccagatctc ggagagggag aggccgtgct cgcgactcac
     5761 caccccgcag gcgcagccca acgtggcctg acgccagtca caggtcacgg tccacgggcc
     5821 gtccttgcct ccgcacttcg ggcagccgac ggtttcggct gtccataccc cgggcgcggg
     5881 tctggtgtgg cgtcggaatc tgccctggta ctggacctgc cagggctcgg ccagcggtgt
     5941 gagcgggaca gccccgggcg cgctcgtcgc ggcgagggcg gtgaacagtg cagtcagatc
     6001 ggggagcagg gcttcgcccg attcggtcgg cggcgccacg ccttccgcca cccccggcgt
     6061 ggttccgtac cttggggccg ctgccgcagc cgttgggttc ggggcggcgt gccagggcag
     6121 cagggcagca gggcagcagg gcgcgggcga cggcggccag gagggcggcg gcaggcgggc
     6181 tgacagcgcc ggtcatcggc agaattccgc ttcgagggcc gcctgctcga gcgcgggatc
     6241 gccccagtcg ccgttgcggt tgatggtgac gacgtgttcg ccgtcggcgg tggcggccgt
     6301 ccgggtcagt gagccggtga tctcgctgct gtgcccccag acctgcacgc cgcatgccgt
     6361 gagcgtctgt gaccggatcc caaggccgta ggacctgccg ccgcccagat cgtggccggt
     6421 gaacatctcc ttctgctggg cggggggaag gagctcgccg cccaggaggg cacggatgaa
     6481 ggcgttcagg tcacgggcgg tggagatcat ctcgccggag gccccggaga aggaggggtt
     6541 gaagtcggtg acgtcgtaga tccgtgcggc agggtcgtcc acatagagct tggaatagtg
     6601 ccgcccgtgc gggccgggca ccgacggcga cgagccgggg accgtggtcc cgcgcaggcc
     6661 gagaggtctg atgatgcgct gttccacttc ggagccgtag ctgtgtccgg tggccttctc
     6721 gatgaccatg ccggccagga tgtagttggt gttggagtag gaccagccct tgccgggcgc
     6781 gaagagcggc ttgtgggcga ggccgatccg caccagttcc tccggcgtgg cgccgtcgta
     6841 ccggtgggtg aagaacgcct tgccggtgaa cttggcgcgg aggccgtcgt cgtcgatgta
     6901 gtcgtagagc ccgctggtgt gctggagcag ctggcgcaga gtgatccggc gtccgtcgtt
     6961 gccgtggccg cgcaccaggc ccggcagcca cttgtccact gtgtcgtcgg tcgacagacc
     7021 gtgctcgggt tcggaggcga gctgcagcag gacggtggcg atgaagggct tggtgagact
     7081 gccgatacgg aagcggtcct gcggaaggcg cgggcggccg gtgcggaggt ccgccacgcc
     7141 ggacgtgccg tgccagctct cgcccgcacg gtcgacccgg gccaggacac cgggggtccc
     7201 cgcgcgcgtg atcgcgtcga gagcgtcctg cgttgcggag tgagcagagg gaggggacgg
     7261 gcgtgaggta gcgcgcggtg cagcggaggc cggggcgacc gcggctgcgg cgaccgttcc
     7321 ggccagtgcc agggtgatca gagtgcgggg taaggcgttc gtggccatgt gggcgttctc
     7381 cgtctccggt tgggttcggt acccggaggg acctctgagc gctacggcag gttgacggtc
     7441 ttcggactgt cgcacccctg agcgaacccg gaaacacccc tgaggcgccc ctgaggctcc
     7501 ccctagcccc ttgggcagtc actggtcgga gcccggtcgg gcggcccgcc gttgaggtgg
     7561 ggccttcacc cgcacggctg gtgccggtgc ggtttggtta cggcagggcc gtgtggttcg
     7621 ggtgtggtcc gggagcatgg aggtgtggac gggaaccggg atgtcggcgg ggccgagccg
     7681 ttgagtgtgc ttgaggtggt gcccacggct cggacggcgg tggcgtggat gccgccgcag
     7741 gagctctggc cggcgattca ggagatccgg tgggagcacg atccgcaggt ccggcggtgg
     7801 ccgccgcatg tgaacctgct gttcggcttc gtaccggagg aggagttcgt acgggctgtg
     7861 ccgctgctgg ccgccggggc ggcggagaac gaggcgttca ccgcgcggct gtccggggtc
     7921 cggtacttcc ggcaccggca ctacgccacc gtatggctcg atccggccgc ggccggcccg
     7981 gccccgtggg cccgtctcca gcaggcgctg gggtcgcggt tcccgctctg ccgcgggcgt
     8041 ggcggccgct tcaccccgca tctgtccctc ggccgcacac aggagccgcg gcagcttgcc
     8101 gccgagtgtg ccgcccggct cggcgcactg ccggcagtgg tcgaggaagt ggtcctgctc
     8161 tcccggcgcg gcgacgggcc catgcagccc cgggccgtga tcgcgctggg cacgggggaa
     8221 gtccgcagac tgccggagta tgagctttag gactgcggaa cccgcccgcg ccccgagccg
     8281 ccgcaggcac atcacgaggg agagcccggc gagtgtctgc ccagtgcggc ccgcgccgcc
     8341 gtgaccatgg ccgtgatccc ggtcggcagg gccaggcgcg ggctcggggc gaagaggggg
     8401 gagtggttgg gcgggagggc ggccagcttc tcggcggcgg tggtgcccgg ggcggccgcc
     8461 cactggcggg ggccggccgt gcccagcatc cagtacaccg tgggtacgcc gtcgggtgcg
     8521 aggagcggga agtcctcggt ggccatggac ggcggccagc cggtgacgcg ggcctcgccg
     8581 aaggctgctg cgtgcgcgtc ccggacggct gccgtgagtt gcggatcggg atggttgacg
     8641 ggagagcgcg aagcgacgga gatctccggc ggcaccgggc agcccgaagc gtcgcattcc
     8701 gcgcggacga tccggtgcac ggccgtcacc acccggtcca gcgcggcgtc ggagaagccg
     8761 cggacggtga ggccgagttc ggcgcggtcg gggatgatgt tgccgcgggt gcccgcctgc
     8821 aggcggccga cggtcaggac gacctgttcg gccggtgccg tctcggcggc gaccactgtc
     8881 tgcaggcgca ggaccaccgc ggcggcggtc accaccgggt cgacggccag gtgaggcgtc
     8941 gcggcgtgtc cgccacggcc gtggacgacg acgtcgaggg agacgctgcc cgccgtcatg
     9001 gggcccgctc catgggcgac catgcccgcc ggcaggggcg cggcgtgctg ggccagtacg
     9061 gcgtcgggcc gaccgaaccg gtcgtggagc ccgtcgtcga gcatggcctg cgcgccgctc
     9121 agcgtctcct ccgcgggctg cccgacgacc atcaccgtgc cccgccacag ccccagctcc
     9181 ccggcgagta cgctcgccgc gcccgcggcc gccgcgaggt ggaggtcgtg cccgcaggcg
     9241 tgcatcaccg gcacggggac gttcacccgg ctggcgtacg gcaggccggt gcgctcctgg
     9301 acgggcaggg cgtcgagttc ggcgcgcacc acgaccagcg gcccctcgcc gttctccagc
     9361 agggcgacga caccgtggcc cccgactccg ctcgtcaccc ggtagccggc ccgggtcagc
     9421 cagtccgcga agcaggccgc cgtgcgggac tcctctccgg acagctcggg gtgggcgtgc
     9481 aggtcgaggt agagcgtcgt gacggcctcg aggaggtcgc gcgggagcgt ggacatggct
     9541 ggtgagcctt tcgggtcggt gccgggctgc tcccggcata ccgctgacac ctgttgtcag
     9601 cggcatgcac agagatctgt cagcgggccc tgctggactg atggggcaag aacgggcgta
     9661 cgggcggcgg atcgccggcc gtgcacgccg gccacagcaa cgacgcaagg agacgcacca
     9721 tggctcagca ggccgaactc gccacgctcg cccaggagat cctggagctg gagtcggaga
     9781 ccttcgagat ctcggactac tcggacgcga gcgaggtcgt cctcgccggt tccaccagct
     9841 ccagctccac gagcacctgc tccagcacca ccagcaccac cagctgctcc gcctgatccc
     9901 aggcagcgca gccgcccggc gtacggccgg cgaaccggaa gccctcgtcc ccgccctggc
     9961 cgagggcttc cggcgcgcgc gtcgtctccg ggggcgacgt tcacgggaac gggtgcggca
    10021 cccgcctgat ctcctcctcc cgcaggtccg tcgaccgcca ccccgctcgc cggaaggccg
    10081 tccgcagccg gtccatgccc aggacccgct gccggtccca gccgaagtcg atgggcacca
    10141 gtccgggcac caccgtcgag acggtgcaca gccccatccg ctcctgctcc ggggaggtct
    10201 ggtcgacgac gatcacgtcg aagccggcgc ccgtcagttc gtcgcggcac agcagcaggt
    10261 cgtccaggag atcgcccgtg gcgggccgct gccgctgcca gggcccgtag agctccgcca
    10321 gtggccggac ggactccggt tccaggtact cgcgcgcgtg ctgcgccatc cgcggcaggc
    10381 cgtacagccg ggcgtggtgg gtgagttccc gcaccaggga gaagtcgtcg gccatggcct
    10441 ccagcgcggt gcggtgctcg gccacctgcc ggtcgaggtg cggcaggtac gtgagcacct
    10501 cggacagcgc cgcttccacc gcctcctccg ggtccagccg ggcgcctgcc gcgaaggaga
    10561 gcgtgccggg cccgccgtcg cggcgtacgg ccacggcggt caccacgggc acggcgaggt
    10621 cgacgcggtt gtcgaaggcg tggacgtcgt agccctggag cgccgcgcgg tcggccatgg
    10681 cccgcaccgc gccgccgcgg cacgacgcca ggtcgatgcc ggtgagccgg gcccgcccgt
    10741 accagccgag caggaacgcg tcccgttcga cgagttccag cagcccgaac aggacggcct
    10801 cctccaggca gctgccggtg gcgcagccgt tggagctctc gaagacgaag ttgtcgctgt
    10861 cgaggccggc gccgtagtgg accgcccgcc ggggcaccag gaccgtgcgg tcgtcgcgca
    10921 gggagtaccc ctgcacccag gggatgggcc gtgcggggtc gaacggtgcg agcatcgggt
    10981 cggtgcggta gacctcgggc gcgtacgtgc cgcaggtgcg cgggtcgacg gcctcgtcct
    11041 gcacgtcgtc gtaggcggcg acgagcggtt cgccccggtg gcggcggtgg atgcccgcgt
    11101 accgttcgag gccctccagg tacgccaggg tccggctggc ggcgaaggag ttggcctggc
    11161 cgctccaggt gacgtcggac aggcccgcgt acgtccggac gaagacgctg cccgcgaccg
    11221 gggaagtcgt gggcgaggcg acgttgagcc aggtcccttc gccgagcgcg ccgcacacgg
    11281 ggttggccag ggctccttgc ggcagcgggt acgagccggc cggccgcagc cgggacgcgc
    11341 cggggccggg cttgggccgg gtgacgagct ccggcggggt gtacggaccc ggaagggggc
    11401 cgcacgcggg gcacagcgga tcgccgagca gcggcagcgt ggtgagccgc agggtggcca
    11461 ggtcgacgcg cgtgacctgg ggcagcggga ggtccgcgga cgtgtgccac tcgccgtccg
    11521 gccggcccgc tccggccggg cgcccggaga gcaggaccgc ttcgtacacg gtccagatcg
    11581 cgtccacggc gtggtcgggc agtacgggcc acaggcctgc cccggtcatg cccgtgccca
    11641 cttcgagggc gtcgcgctcg gagcgtgagc gcagccgctg ccagcgccgc gcgagacaac
    11701 cgccgcacgc tgcagggata tccccctgcg cgccccaggg gccgatcagt gccgcctgcg
    11761 cggtcaggtg cacggtggcg cgggggcgca gcgtgccgta cgggtccgca gcgggccgga
    11821 aggcgtcggc cgcgcccacc gggacgacga cgggagcggg atgatcggcg acctgccgcc
    11881 ccgaagcccg gaagcgttcg gagagggcct gctggagccg ccggctcgcc gcggccatgg
    11941 ggtcggtgac cagcgcagcc gtggtggtgg tcgtggtcgt ggtcgtggcg gcggtgctca
    12001 tgaggcgttg ctccagcgga aggtcttcac cgcgatcccg ccgaagacca gcgcgaagag
    12061 ggccagcccc ccgcacgcca cggcggtgga ggcgaggtcg gcgcgcccgg agaccgcccg
    12121 cgatatgccg tcgttgagat agtgcagcgg cagcaccctg gccgcggtct gcagccagga
    12181 gggcatcgcg tccagggggt agaacgcccc ggacaggaac gccatcggca ccatgacgca
    12241 gttggccacg gccgccacgg cctccggggt gtcggcccgc gagccgatca ccatgccgat
    12301 cgcgaggaac gcggtgatgc cgctcaccag gaccggcagg gcccacggcc acgtggcgtc
    12361 cacgtgcagt ccgaagaccg gcagcagggc cacgccgatg aacagcaccg cctggacggc
    12421 cccgatggcc agggcgatga cgtaccgcga ggcgagaacc gagccgaggg gcgtgggcgt
    12481 cagccggatc agccgcagca ggtcgtcgcg gcgccactgc atcagagtga acgccacccc
    12541 gaagacggcc gcgttgccca cgccccatga caggacgccg ggggcgatgt agtcgatgta
    12601 gccgcgcccg ctctgctcca ccgtcttgcc gcggaagatc agcccgaaga cgaccaggaa
    12661 gatcaggggg aaggcgaagg tgaagaagac ggtggtccgg tcgcggacgg cggcccggta
    12721 actcgccccg gtcagtgcgg tgtaggcgct catgcgtgct gctccgttcc ggcgagctcg
    12781 cccgtgagct ccaggtagac gtcttcgagg gtggcggtgc gggtgcggat gccgtcgagg
    12841 ccgacgtccg cgccgagggc ggccagcagc ggtcccgccg accgggtttc gatgacgacc
    12901 gagccgccct cggcggtgac ccggtcggcg ccctcgaagg cctgtgcccg ttccacggtg
    12961 atccggtccg ccggtaccag cagccgggtc ggcgcctgcg cggcgccgac cagccggtcc
    13021 gggctgtcga gcgccaccac ccgtcccgcg acgatgatgg ccacgcggtc gcacagcgcc
    13081 tcggcctcgt ccaggtgatg ggtcgtgtag acgatcgtgc gcccttcgct cttgagcgcg
    13141 cgcagcacct gccacaggac gcggcgcgcc tgcgggtcga gggccgcggt cggttcgtcg
    13201 aggaagatca gctccgggcc gtggacgagc gcggaggcga tggcgagccg ctgccgctgc
    13261 cctccggaga ggacgtcgac gcgcacgtcg ccctgctcgg ccagtccgac gagcgccagg
    13321 gtgtgctcga ctcgggcggg gccggatccg tagagggccg cgacggtcgc caggtgttca
    13381 cgtgccgtca gccgggtgaa gaaggcagag gtctgggtct gcacgcccat gcgcggcagc
    13441 agggcgaggt tccggggcca gggggagacg ccgaggaccg agacgctgcc cgcgtcggcc
    13501 ttgcgcagcc cctccatgat ctccacgagc gtcgtcttgc ccgcgccgtt cggcccgagc
    13561 acgccgaaga actcgccgcg ctccacggtc agggagatcc cgtccacggc ctgtttgtcg
    13621 ccgtagcgct tgcgtacgcc gtccagcacc agggcggggg ccgccgcgcg tgcggacggc
    13681 ttcgtgtctg tcatcgttcc tcagctcttc ttgcggggtg tgttacgcgt tgcgttgcgt
    13741 ggtgcggatg aggtctgcgg gtgccggtcg ccccgccggg cccacgggcc cgtcacggcc
    13801 accagcgcgg cgaccagcag ggccggtacg acggcggccc acaggccgta gcggttcccg
    13861 gccaggtgat ggctcagcag gacgaggccc gccccgctgc cgccgacgag gagcaccgcc
    13921 cccaggccgt aggcggtgta cgcgatgcgg gccgaccgcg ggtaggccgc gacgccgtcg
    13981 ccccgccgta cggcccgcgc gcccagcagc cgcaggaagc ggcggctctc ggtcgcgtag
    14041 tcggccatgc ccagggcttg gccgagcatc ttgtagccgt ccagcggcgg cagcggcacc
    14101 agattggtga gcgccagcac cgacccggtg aacagcaggc cggccagcgg gccgcgggca
    14161 gcgtcgtcgc cgggcaggag ggaccacagc agccagaagg gcagcaggaa ggccaggttc
    14221 atgaccgtcc cggcggccgc ggtggcgacc cgtgcccggc gcgtgggcag atacggatag
    14281 ttctcgaccg tgcagtacat gaacaccatg ggcaggtgcc agcgcagccc gatctcgccg
    14341 acggtcccgc cgaagtgccg ggcgacgacc ccgtgggcca gctcgtgcag ggccgtactc
    14401 gcccacagca gggtgaacgc ggcgagcagt gcacccggct gccggaacag gcgcacggcg
    14461 tcgtccagga acgcccctgc gtgcacggcg acatacgtct ccatgccgag caccagcagc
    14521 aggacgggca ccacgaccac cggcgccagt gcgaaaccga cggccctgta cagccggtcg
    14581 gtggtggccg tggcatccgc ggccagccgc agcgtgccct tgaggagggt gccggtgacc
    14641 agcttgcgcg gcgcggcccc ggtcggctgc ccggagacgg cgggctcgga ggagccggcg
    14701 cccccggcgg acccggcgga ctcgacgccc ccggctccct caagcagccg ccgctcccac
    14761 agcagcttca gcaactgctg ccagtgggct tcgccgagcc gccgcccgaa ccgcgccgcg
    14821 tactcctcgc cgacctcacc gagcgtgcgg gacccgtcca ggcgggacat caggaagtgc
    14881 tccttgaccc cgacctcgaa ggactgccca ctgcgcgggt ccttcaccag atggacgacg
    14941 gccggtccgc gccgcagcgc agagctgcgc aggatctccg ggcgcagggc cggccgctgc
    15001 tccagcagcc tgtgatgcgt cgggggaggg gtcgagggag acgtccgcgg agtcatcggg
    15061 ggtccgcctc gcgcaaggcg cgcccgagga cgtacgacag gtacgcctcg tcgcggatgg
    15121 tcacgtgcag ccggttgttg gtcatgtgca tgtacggcga cagcagcagg ggcagggcga
    15181 ccgccgggtc ggtgacctgt tcgtcggccg tgccgtccca cgaacggaag acgagatcgc
    15241 cgcggacggc cagcgcggtg gcccggtcgc gcagctcggc acagtgctcg gcccagccgc
    15301 gcaggaagcg gggcagctcg gtgagcccgt cggcggcttc tccggccagg gcacccagga
    15361 cggcaccgaa gcgccgcgcc ggcgccgggc ccatggccgc gtaggcgcgg tcgtactcgt
    15421 ccgagccgat gaagttcgtc ccggagaaag ccttctgcca gaacacgtga tagcggtcca
    15481 ggtactccgc gagctccgcc cggccgggca ggaacgtacc ggccatcacc atcatcagct
    15541 gggcggacgt gcccaggcgg acagtccgca gatggaggtt catggtgcgg acggcctcga
    15601 tgaccaggtc gctggagtgc cggaagtgcc actcggcgag ctccacgccc gccgggccgc
    15661 cgtacttgcc gtactcgggc tcgtacggct cccggctgac ggtgttgttc ggccgcagcc
    15721 gcatccgccc gtcggcgtcg aggaagccgc cgcgctcgtc ctcggggaac tccagctcga
    15781 agagggtgtt gtagaactcg ttgaggaagc ccgaggaatc cacctcgtag agcgcgggcc
    15841 gctcccgcag gaatgcggtg acggcctgct cggcgcgctc ggcgacctcg tccgcgacgg
    15901 cctcggagga gggcttgagc cgcagccgga cgtgcgggcc ctccagccag tagttgatga
    15961 agaagtggcc cgccagcagc ccctcggcag tgagctccgc aaggagcggg ccgacgcacc
    16021 gggtcatcag gggctggggg ttggcggcgt agtggatgtg cagggcctgc caggcgccgg
    16081 gcgtggcgag ggcgggttcg gtcatgtcgg cgcaccggtt ccttcgcggt cgtgacgggg
    16141 cgtgcggagg gtctcgacgg ccagctcggc catgtgggtg ccgcgtgcgg agacggcgtg
    16201 cagctcgtcc tcaccgggca gggcctcgcg gagcacgacg cggccggccg ggtccttgag
    16261 cagcccctcc agggcggtga gggacagcca gctgtcgaag tcgacgtact gcggcttcgc
    16321 ccggtccgcc cccggggcgg ccgcggtcgg ggtgacggtg gcgaagacgc ggtgcggcag
    16381 cccgtgccgc acgcgccacc gctgccactg caggaaccgg tcggcgtcgc cgcccccggc
    16441 agacccgctg ccgagggcag gcagcgcggc ggcgggggcg gtccagctgc ggcggctgag
    16501 gacgagaccg ccgcagcgca cccgcggccg ggacgtcacg ccgtcgtcgg gttcgccctc
    16561 cggaacgccg ccccacacgt cgagcggtgc catcgacgtg ggggagagga gcagcagggt
    16621 gcgggggatc tcggggagcg ccagggggac gaggtagccg aggtagacgg gaacgacctc
    16681 gcggtccagc cgccgggagc gcagcaccag acggtccgcc tgtacgtcgt gctccaggta
    16741 caggtcgtcg agggcgatcc ggctcccctc cgggacgccg ccgtcctcgc ccgggcagac
    16801 gatgcggtag tccgtcaggc gcccgtgcag attgaggttg ctggtggcgg ccccgccggt
    16861 gatctcggcg aagacggcgc cctccggcgg tacggcggcc gcggtgcgcc ggatccgggc
    16921 ggagagcgcc ccaccaccga taccaccgtt ctcgctgcct tcgctgcctt cgctgccttc
    16981 gccgtcgaag cagtgggtga agcggctgaa ggggaaggcg aacccgccgt aggactggtt
    17041 gagcaccgcc agcggttcgc cgtcgcggcg caccagctgc aggaaatggc tctgcggcgc
    17101 gaagcggggc gcgacgccgg tgagccgccc ggcgacggcc tcgaccgtct cggggtggac
    17161 gcggatctcc tcggcgcccc gcgcggtgtc ccagaggcgg cgcatccggg acgtccactc
    17221 ccggcgggcc gcgtccacgg ccgtgatgcc gggcaggccc agccagttcg gctcggggac
    17281 gtagtcgccc tgcgcgtcga agggcttgcg gcgcgcggtg aacgtcaggt actggtcgta
    17341 gaagtcctcg tggaagtcgt gcacgagctt caggaggtct tcgcagcggc cgccgctgcc
    17401 gtaccgcgcg acgaagaagc ccttgagcgt gatgcgctgc ggcagggtca ggtcgaaggc
    17461 gggcaggatg cgttcgagcg agcacagggt ctccagaggg ccctcaccgg cggccgtgac
    17521 cggggcgctc cagggccgga ggtcgcagac gacaccggtg tctccttcct cgttgccccc
    17581 ggcccgcacg tcctcgtaca gcagggtccg cggcagcgtc ggctccgccg ccccgagttc
    17641 gcgctggatg cctgtgaggg cctgccgcag ctcggacagc agctcccggc gcagcttcgg
    17701 acctgcggcg gcgtagcggc cgacacagtc gatcggcttc tccagtgcct cggcgagccg
    17761 tgccgcccac ggcctgtcca gagcctgcag ggcgtcgcgg aaggcgcgca gcgggtcggc
    17821 gtcgtggacg tcggtgcgca ggcacgggat ctgcaccatg cccaggtcca gcagggccgt
    17881 cagatagcgc tcgcactcgt ccgggccggc gccccgctcc tcggccagcc agcgcgcgag
    17941 gtcccggtag cgcagctgcg gccgctcgcc gaacagcgcc agcagcttct ccagcgtgtc
    18001 gctgcggcgc aggaagaaca gccggtcgcg ggcggcgtcg aaggtgaccg ccgcgccgtc
    18061 gtcgcccgcg gtcaccgaac ggcgcacgta gcggacccgg tcctcgtcgt gcctccagcc
    18121 cgaggacagg gtgacgggga ggtcgccgcg ccgcccgggg tcggcggcca tgagctcggc
    18181 gagccgggcc aggaccacca cgttcagccg gggatggccg gtccactcct ccggaacgcg
    18241 gacgatgccg gggtcgctct ccgtgccctc gccgccgtcg ccggcctcgc cgccgtcggc
    18301 cccctcggtg aaacggccga gggcgacggc cgtgaaggtg ctgaacgggc tggtcttgca
    18361 ggccgtgcgg tagaggtagg cgagggcgga gcgctcggcc ttgcgcagcc gcttgtccgg
    18421 gcggcgtccc gggtccgcgc cgatgtacgc gtccagccgc tcctccagct ccggcgacgc
    18481 cagcagcagc cccagacgca gccgctcctc accgagcagg ccgcgaaggg cggtgcgggt
    18541 gcgggtggtt tccgcggcca ggagcggggc gccctcggtg agcaacccgt ccagcgcccg
    18601 ccggtcgcgc acccagcggc ccgcatcctc ggcggccccc gtgtcgtcgg cggcgagcag
    18661 ggcgagggcc tgctcgggcg cgccgggcag cctgccgttg aacacgtccc gccgcagccg
    18721 cagcaacagc cgccgggcgc cgtcgtcctc cgccgccttg accagggggt gcagccggtc
    18781 gctgagcgca gctccgcgcg agcgcagccg ctcctcctcg cggagtacgc gctccgccca
    18841 gcgcacggtg gccgggcagc gcagggcctg tacggactcg acgggcagtc cggccacgcg
    18901 cagcatgaag tgtgggctca gcgaccagtg gccggttccg gttccggttc cggtcccggc
    18961 cgcggttccg gttcgggtcc cggtcccgtg ggacggggat gatgtcgtgt cggtcatggc
    19021 gtccccgcgc actcaggcga tctcgtagcg gaagtcggcg gagccggggc gttcgtggcc
    19081 gacgagcatg atcagcagtg gtgcctcgcc gctctccgcg agctccagct cctcgacgaa
    19141 cgacacggtg tcgaagccca gcgcgacccc gctgcccacg ccgagcgcgg tcgccgcggt
    19201 gtagaaggtc tgcgcgaccg ccccgacggt ggcgttgacc agccggtagc cgcggtcgcc
    19261 ggccgcgtcg agcacggcgg cggtgcgcac ggcgggcacg acgacggccg cggcctgttc
    19321 caggttgtag ttggacagga agtagttccg ctggaggaag tcgcccggcg gccccggctt
    19381 gaccagccgc agcccgtgcg cgctgcccgg ctcgtaggcg tacgcgccgg gagcgatccc
    19441 ctcgacgtgg ttgacgaaga cgtagagtcg ggcgagccga ggcgtatccg gccaggcctg
    19501 cccgtccggc caggcctgcc tgtccggacc gtcctgcctg tccggaccgg tcgcgtcgct
    19561 gccgacggac gccgacgcgg cggccgccag cgtcgcggcc agctgatcgg cggcgagcgg
    19621 ccgccgggcg tcgaaccggc cgaagctgct gcgccgcctg cgcagcgcct cccgcacgcc
    19681 catgctcagc ggtgcaggct ccggcagggc cacgggtgcc gcctccggtg cgctgctcgg
    19741 cggctccggc gaaacggccg ccggagcgag cgcgccgggc tccgggcggg cggtggcatt
    19801 ctcgagggtc gcggcctgga tccgccggac ggtctcgaag gggatcacgc ggcgggagcg
    19861 ttcgctctcg gtgcggcgca cccggggcgc aggcccggtg gcacgtcccg tggcggccgg
    19921 ggccgttgta cgttcccagg tgagcggaac caccgcgaag acgccctcgt ccaggacgtc
    19981 gaggccgagc agccgggcga tgcgctcctc gtcgaaccac agggcgggct cgatgcgcag
    20041 gccccgggcg cgtgcccaca tccgccaggt ctgcagcagg gcgccgacgt ccatgctgac
    20101 cgcgtgcatg caaaagctgt tgtacttgaa ggcgttctgc cagaacttga cgcccagcac
    20161 caggaactgg tcggtcgcca cgtccgggcc caggccggcg gcctcgcgca cctccgccga
    20221 gacgtcgccg gtcagcagcc gctgcatggc gtggtgcgtc gtggagtagt ggtggacccc
    20281 cggtgccagg ggcccgccgg gtccgttcac ccagtagacc gtcgcggggt agaggccgcc
    20341 gcccgaggcc gttccccgcg accagttggc gtcggtgtag aggggcagcg acggcaggtc
    20401 ggtgttggcc tggacgccca gccgccgccc tgtgcggccg tacgagtcga gcagcatccc
    20461 gcccatcagc ggcagggaga agcacccctc ctggcggccg gcgccgccga acaccccctc
    20521 ctgcacggtg gccgcgggcc cggcgtcgtc gccctccggc agcgggaagg actcggcgcc
    20581 cgggtagaac ttccctttgc gcggccggtc cgaccagtcg ggaacgaagc cgacgggctc
    20641 catgggaatc ctgccgcgat gcatgatcgc agtcgcgtat tcatgggcga aacccactgg
    20701 ttctccttac gtgacgtcgt gacgtcgtga cgtgttcggt tcggcaaccg ggggagggaa
    20761 ctgctcaagg gaacggatgc ggagccgggt tgagctcgtc cgcccgtagc tcgcgctcgc
    20821 gcagcccggc cgcatacagc gccgtccgca tccgcggcat ccgcagcgcc cgctgccgct
    20881 gccagccgaa gtcgatcggc agcagaccgg gcacgatcac acagaccgtg tgcaggccca
    20941 ggtcgcgctg ttcgggcagg gtctggtcga cgacgatcac gtcgaatccc gcgccggtca
    21001 ccacggccac gcaccgctcg acgtcgtccc ggaggtcttc cgcgacgggc agcatgcgct
    21061 cgcccggtgc gtacagctcc gccatgggca gcttcggccc gcggtggccg aggaggaacg
    21121 aggcgtgcgg agccatctcg gggaggccgt agaccagtgg atggtcgtgc agggccagca
    21181 ccttgtcgaa gtccgccgcc atggcacgca gccgtgtgcc gtcccgctcg gcccggcccc
    21241 ggatgttcac cgcgtcggtc gcgatttcgc acagcccgcc ggccagggcg gcctccgggt
    21301 cgaggccggc ccccgcgccg aagcacagtg tgccggtgcc tccgtcggtg cggaccgcca
    21361 ccgcggtcac caccggcacc gggaaggtga tgcgggtgtc gaagaaccgc gcctcgtagc
    21421 cgtacatcgc cagccggtcg accatctgcc gcgtccgcgg gtccgtgctg gtctgcgggt
    21481 cgatctcggg gagggcggcc cgcccgtacc aggcgagcag gaaggcgtcc cgctcgatca
    21541 cctccatcag cccgtggtgg acggcctcct ccacagagcc gcccgaggcg cagccgttgg
    21601 agctttcctg gacgaaccgg ttctccaggc cgggcgtgcc gtagtaggtg aggatctccg
    21661 gtacgagcag cggccggtgg tcccgcaggg agtaccccca gacccagggg atctcccggt
    21721 cgggggagaa cggcaccacg cgcgggttgg cccggtggaa ctcctccgcg tacaggccgc
    21781 actcgcgcgg gtcgagcgcg tcgtcaccca gggcggcgag ggacgcccgc acctgcgggg
    21841 accggccgcg ggcccgcatg cccgccgcgc gttcgagacc ctccaggacg ccgatgcgct
    21901 cgctgtcggc gtaggagtcg gcgtggccgc cccagaacgt ctcgcgcagg tactcgcccg
    21961 agcgcagctc gaagcagccg accgtggccg atgtcgacgc cgaggcgacg tcgtgcacga
    22021 caccggggcc gagcgccccg cacaccggat tggcgaacgc cctcaccggc agctcgtact
    22081 gcgagaccgc ccgcacccgg aacgagccgg gccggtgctt gggcgcgggc tgcagggtga
    22141 gctccgcggc ctgcgcgctg tcggggacgc ggcgtccgca gtcggggcac tccgcgtccg
    22201 ggacgatcaa gtggcggctg acgtgcaggg tttcgaggtc gaggaggtgg acggcgggga
    22261 agggtccgtc ctcgtcggcg gcgcctgtgg ctgggctgtc tgcggtacgg gcggctatca
    22321 gcgcggccat cgcgtccgtc aggaacggta gggcgtacgg aggccgcccg gcagcccgtg
    22381 tgtccgaccc cagctccagt gcatcgcgca gggcccggcc gcgtacggac tgccagcggc
    22441 gggccagaca gcgggggcag ggcacgccgc cgtcgcggtg cgcacggtcc ggccggggga
    22501 aggggccgat gagcgcgtgg tgcccgtaga ggtggacgcg cggcgcgagg tccccctggg
    22561 ggagggcctc ctgagccagt tcgtcgcgta cgcccagcgg tgccacttcg gtcggggcgc
    22621 ccgtacccgc gggtgatgcg cgcaggagcg cggcgatgtc gcggcaggca tgctcccact
    22681 cgggtggggc gggcgagagt ccggtgccgt cggcggcgat gctggggacg ccggcggcgc
    22741 cggcggggcg ggcggtgtcg gacgggcggg cggtgtcggg aaagctcggg cgggcgacgc
    22801 cggggtcgtg ggcggtgccg gtgtcagtgg gagtcatcgg agccctcggg agcgttcccg
    22861 gcggagccgt cgcgcgtgag cagcacgcgg accgtgctga tgccgcccgc gaggaggtcg
    22921 gccgagccgg tgggcacgac gagcgcgtca cgtcctgcgg cacgcagccg gtccagcacc
    22981 gtcgcgtacg tcgtggcatc ggaggcgtcc agacggccgg cgctcgttcc catggtggtg
    23041 agggtctcgg gggcgagatc gcccagcagc ggatcgccca ggtcgacgga ggaggcgcgg
    23101 ccactgcggt cggctccggc gagttcgcgg ccgagctgtt cctgtcccag caggtcgcgc
    23161 agggccgtca ccgcggcctg ccgccggtcc gtggcgcctg ccaccgccca ggcccacgtg
    23221 ccggagtggg ggaggagtgc ccgggcgaac aggacgtggg cggaggagcg ttccgtctcg
    23281 ccgaggtcga ggagctcgta cctctcgatg ccgaggttgc gggccgagct gaccaggaag
    23341 gtgagctccg gatcgtcccc gtgggcgtcc ggggcgatga gggccgcccc gccggtgcgg
    23401 cgcagggcgc gttccagcgc gtcgtggcac agcgcagaga gcagtccttg ggccgtggcc
    23461 tcgggggtcg tacggcccgc gccggtgccg gcggacgtgg gggtgtggag ccggtcgtgg
    23521 ttgtacgggc cgaaggtgcg gaccgcgcct gcaggcacga gcgccgggcc cgcgccggtg
    23581 agggaggagg cgcgtaccca ggcggtgacg tcttcggcgc gggcgggcag gccgctggcg
    23641 acggtgagcg agtcgggacc gaggacgcgg agccggccct gcgcccggtc ggggcggacg
    23701 gcgtccccgg ggagcacgcc tcccaggggg acgacgtgct cggcgtagac gcaggccgcg
    23761 gtgtccaggg ccgtgagccg ggcgccggcg acggtgtgca ggtcgaacgc ggcgatctcg
    23821 cggcttctcc cgtgccccag gggcaggcgc accgtgccgg ccttgagggg ggtctgggtc
    23881 cacggctcgt ccgtgaaccg ttcgaagacg cccgtgtgcg gccggacgag tatctggcgg
    23941 ctgttgagct cggcgaggag cgcgtccgag tcgatgctgg tgggggcgat gcctgtggag
    24001 tcgatgcctg tggggttggg gccggcgggg atggtcgtag tgatggcggg tgcgggtgcg
    24061 ggtacgtcgg ggagggcaac cggggcggcg gccggggccg ccggttcagg ggccgcggcg
    24121 ccggtcgtgc ggcagaacgg gcaacggggg tgcgcgagca ggggctcggc gaccacgtcg
    24181 aacgactcgg tgtcctggat gatcacctgt ccgagcgtct cggcgggcag cgcgcccgtg
    24241 gtgagccgga agacctcgta gccaagaagg ttgccgatca tcgccgagag gctgcggccg
    24301 ggctgctgcg cgagaggatc tcctgctgcg ggcaggcaga tgccgctcca cagatcggcg
    24361 gcggccgcgg cgtctccatg ggcgccgaga cgcagcacgg cacaggccca gcagccggtg
    24421 ctcccgtgcg tcatgagcgg gccgacgacc gcgcggctgc cgaacatggc cgccggtacg
    24481 agcgacttgc cctccggcac tccggcttcg agcaggcgga agagcgggcg cgggccgtcc
    24541 gtgccgccgg tgacgacgac gatgtcgtac gcggcgaggt cgctccagga caccgtcacc
    24601 ggcccgtcgg cggcctgccc tgctgcggaa cccgtcgctt cgatcggctc cagggagacg
    24661 gggcatccgg cggcgcggag gccctccgcc tcctcatgag cgcgggcgaa acgatcctcc
    24721 gtaccggctc ggtggccgac ggatgcgatg ccgttgcgga ccaggccgag cgcgcaccag
    24781 cctgcgaccg catcgtcgcc gagtacggcc acccgggccg tacggaagtc gtggaagcgt
    24841 cgttccgcgt cgtcggcgta gtggtcggcg taggcgatct gcggcgcgaa gcgctccgcg
    24901 acctcggggg agaaggcggg aggagccgag gtgccggggg cgggcgtgtc acgggcgaac
    24961 tcccgctcgt acagcgtgct caccaggctg ccgaccatgg cccgctgccc gtcaccgagc
    25021 ccctcgcaca ggtccgcgac ccggtgcttc ccgttcaggt gcgggacgag gagggtggcg
    25081 aagcggtacg cggacgggga gttgacgtgg aatccgccgt gggcgttgtg gaacagcacg
    25141 ccgtccgggg tgcgggtgaa aaggacgtca cggcggatgc ggggccgtgt cccggcaatc
    25201 tcttcgtagg cttccagcat gtgtgtacac ctcatggact cgtggaatcg tgacgctgat
    25261 tgttgaaatc ggaaacgtga tggaggtgaa ggttcgtgga ctcgtaaaga tgcggagacg
    25321 aattcactgc cgcgacggca acgcgaggga gccgtcctgg tatccggtgt atccggtggc
    25381 acaccgggcg aatgtccgga gcagttcgtg catacggaag cgaccggccg gctcctcttc
    25441 cagcaggccc gcatccgcca gttgctccag aatttcctcc gcaggcaccg gcggtatccc
    25501 gagaaggcgc gcggcatcgg cgaccgaaag cggggccggc ggggctccgc cgatgcggag
    25561 gaacacctcg gcgaggcggg ggtccagccg ctgcagagca tcgcccagga cccggggaac
    25621 cgacatccgc gggtcgtcgg gcagggacag cctgcgcatc gggtcctcgc gcagccaggc
    25681 cacgcagtcg gcgaccgcca ggcgcgggcg ggtgagaagc cgggcggccg cgatccgcag
    25741 agcgagaggg aagtgaccgc aagcggccgc cagctcgcgt acggcctccg gctccgcccc
    25801 ggcccggacg tccccgaggg cggccgacag cagttgggac gactcgtcct cggcgagggc
    25861 gtccaggcgc gtggcccagc cgccgtgtgc cgccaccagc ccggccaggc cgagcctgct
    25921 ggtgaggacc gcggcgctgc ccgtgccggt cggcagcagc ggccggacga gggcggggtc
    25981 cgccacgtcg tccaggatca gcagcactcg gcggtccgca ccgcaggcac ttgctgggcc
    26041 gggcgccgcc gccatgccct gcagttcggc ggcgacttcc gccgacgtgc gcggcgtgcc
    26101 gtccgtccgc gtcatgcgca ccgcgaaccg gccgtcgggg aagtggtgac ccacgagctg
    26161 ggccacgtgc agggcgagtg ccgtcttgcc gatgcccgga gcgcccgaga ccaccaccag
    26221 cgcggggccc gagcggtcgg cggtgaggcg ggcggcgatc gcggcgccct cggtcgcccg
    26281 cccggtgaag gaggagacgg cggtgatggg gagggtggga gggggcgtga ggataggccc
    26341 ggatgctgat gctgatgctg atgcgggtgt gggtgcggat gatggggagg gtgtggacgt
    26401 ggaagggaag ggcggcgcgg tgactgcggc gggccgggcg gcgggattcc cgccggcgac
    26461 gtcccgaccg gtgcgagcag actcccggac aggcacggca aggggcggag gtcccaggac
    26521 gtcgccgcgc aggatgcgca gctccaggcg ctgcagcgcg gggccggggt ccaccccgag
    26581 ttcctcgcgc aggtaccgct tgacgtcgcg gtactcggcc agggcgtcgg ccttccggcc
    26641 gctgcggtag agcgcctcga tgagctgttc ccggaaccgc tcgtgaccgg ggtgggcccg
    26701 ggaggcggcc cacagttcca cgagggcctg gccgcagcgg cccagcagca gctcgatgtc
    26761 gcaggcccgc tcgacgaccg acaaccgctc ctcgacgagc cccggcaact cgccccggcg
    26821 caggaagtcc gaggggacgt tggacagcgg cgccccctgc cacagcgcca gtgcctcccg
    26881 gagcaggcac aactcggcct cgggatcctg tgcggcccgt gccccggccc gcagctcccg
    26941 gaagcgcacc aggtccaggg cgccgtcctc gaccacgacc cggtagccgc cgggaacgga
    27001 ctcgatgacc gcctcggcga ttccgtactt gatgaaggtc ttgcgcagcc gcagcacgca
    27061 cgtgtgcagg gccgccttgg cggacgacgg ttcgtcgtca ccccagatcg cctgccgcag
    27121 gaagtccgcc gggaccaccg cgtccgggcg caggagcaga gaggcgagca gaatcgtggg
    27181 cttggacggc gggaggacga ccacctcggg cccgtcggcg atccgtaacg ggccgagaac
    27241 ctgaaagcgc atattctgac acccccaatg atggcttata ggtatccaga atccggacac
    27301 aaggacactt ggacgcaccg gtgcatgggc atacggcacc ggccgccacg ggatgcactc
    27361 accgcgacgc ctgcttcgct cccagagtgt gcatcacgta atccgccact cgtagtgtcg
    27421 tgagttccag tggcggtacg ggcgagggtg ggacgtggcc gtggcgagaa ccggacggga
    27481 ggtgaaaacg cggaatgaac tcgcctcgaa gaaaaggcgg atgacaaggg ctggtcaacg
    27541 tcacccagat caggtagaaa cgggcagagc aatgatcgtt ttcaagacag gcccgtgaat
    27601 ccatggaaaa tcaggaccag agtcccgagc gcccggcgac ggtcacgtgc gccccgcacg
    27661 cccaatccgt cagccggctg ctgcgcgctt ggagggaacg cgtcgaccgc cggcgcatac
    27721 ccgaactgcg ccgctgggga caccggtccg gaacgcggat gtcacaggcc gacgtggcca
    27781 gactcaccgg cgtgagcgaa ggctggtacc gcgccctgga gaccggcgcc ccccgcgaat
    27841 tctcggacgc cttcctgctc cgggtcgccg aggcgctgca gctgagcgag accgagaccc
    27901 tcacgctctt cctcggcgtc tcgggccgcc gcccgcccgt ctccggcacg cacgacggcc
    27961 tgccgaccgc cgccccggcc accgtcgccc tcctggagca ccaggccccg cacccggcct
    28021 acctctccga cgccgcctgg aacatcctcg ccgccaactc gcccatgacg gagtggttcc
    28081 ccttcgccct cggcccccgg cccaacctca tgcgctgggc cctgacctcg gccgaggccc
    28141 gcgaacagat cctggactgg gaggacacct gcgcccgcac ctacctcccc atgctccgcg
    28201 tcgccagcca cggggccccg aagaacgcgg agatccgggc cctgatcgac gagatcctcg
    28261 ccaccaacgg cacctgccgc cgcatctggg ccgagcagca cgccgtggtc gaacaccccg
    28321 gaggtcaccg cctccgcctg cgcctgccct gccacggtgg cgtggagacc caggtcacca
    28381 gccacgtcct cgtcccggcc gagcagccgg acgtgcggtt cgtcatcgtg acgacggtgg
    28441 actgagggtc cgtgtgcgcc tggcgcatgc gttgggggag ggatggtgga gcgggttccg
    28501 ctccaccgag cgagccgggt ggcttgccga gggcggcggg ttctgccccc gggatgcccc
    28561 tggcatcggt gagtcgacct cccctgagat ccgtcggggt aatcccccat ttcctcgatc
    28621 ggatgttgcc ggtctcctga gcctctcagc agactgaagc catggcaggc gacctctccg
    28681 aagcagctga ttcctcactc cgtcgacatg tgtccgagca gcggatatcc caccgggacc
    28741 gggatcaggc cgtggagatc ctccgcgtcg cggccggtga cggccggttg acgatcgccg
    28801 agctggacga gcgcatagaa gcggcgatgg cggcacgcac cgcctccgac ctcgcggtgc
    28861 tgaccgctga tctaccgctc gaagggatgc cgccgcaggc ccgcgaggtg atccggatcg
    28921 accagcgctt cggcgaaggc aagcgcaccg gtcgctggct ggttccacgc cggatggaga
    28981 tccggctgat gttcagcgac ctgaagctcg acttcaccga ggccgtgata acccacgaca
    29041 ccctgcacat cgaggtcgat ctgcgtatcg gcggaaatct gaccctggtg accggaccgg
    29101 ggatcgtggt cgatgccgac gacgtcacct atagccgtgg tgagatcaag gtccgcccgg
    29161 tcgccggccc ggaggctccg gtgcgactgc gcgtcgttct ggccggcagg tcgaccggtg
    29221 gcgacatcgt ggcccggcca ccgcggggca cgcctcggca gtggcttcga cgcaagcctc
    29281 gagcagcagg caacgcccgt tgaccggctg acggtgggcc gacctgcgcg ccggagacgg
    29341 gtcgccacga cgtcacccga ggcgagaaga gacagcaacg gcccttccgt gcagtcgcca
    29401 ccccaccggt gctccccggc cccccggccc cccggccccc ggccccgacc gcgcgagcgg
    29461 cgaactgtga ccgtgacctg ttgatgaaaa cgctttctgc tcgggcctgt tgtcgtggag
    29521 gatgagcggc ggttcgtcgg cggtggggac cgggaggaac tccggccccg cgacacgccg
    29581 gctttgaagc ttgaagggag agcaagccca tgaaggtcgc tcagggaagt ctctggcgag
    29641 ttcggttgtc ggccgctgtg gccgggttcc tcgctttggt ggcattgtcc gtcccctcct
    29701 cggcagcaca cgccgccgtc ggtgcccagt ccggccctgt ggagcccggc gtcccctact
    29761 acctggtggc cacgaagctc gaccggggca tcacggccgg aagagccagt gaatacgggg
    29821 acttggtcca ctacacggaa cgggcgggag accagggcac acccgtcgtc ttcgagaagg
    29881 acagcaacac cacgtggggc gagggctatc agatacggct gcagcgccgg ggcagcgcca
    29941 ccatgctctg ccacacctac caccgatgga tcgccctgat ggacagctgc cggcagaacc
    30001 cctggatgct ggaacccagt ggggacacgt tccgtctgaa gacccggtgg gacggctcct
    30061 acctgtacct cgcggcgtcc cccaccttcc cgagcgacaa gacgctctac tggaaggacc
    30121 ggtacgggag cgacgacctt aatgtgacgg agttcaagtt ggtcaaggca ccgcggtagg
    30181 aaagccgccc cgtgggccaa cggtggcggc ccagccgctg cgagggctcg gcgctcctac
    30241 cgggcgccga gcccctccag cgccaggcgg tggagcctgc cccagacccg ggcctacgaa
    30301 tgccgtacct gagcaggggc aggggccggg gccgggagcg gggccggggc cggggtgatg
    30361 cgatcaggcg gtcttcgcgg cggctgcggt gagcttctca gccgccttgg ccagcgcctt
    30421 ggagaaggct tccttgccgc ggtcaccgtg gtccgagtag ttgttgagga tcgtggtgat
    30481 ggctccgtgg ctgcgcatgg tgcccatgtc gaagtccatc tgcatgtcgc ccgcgacgac
    30541 cttcacggtg taggtgaccg attcgtcacc gtacttctgc tggtcggcgg tcttcttcac
    30601 ggtgaccgtc gccttcttgc cgttctgctt gcccgtgaag gtcgcgcact tctcgacggc
    30661 gttccgcagc ccggccatgg ccttctccgc ctgagggcgc gggtatccgc tgacgtcctg
    30721 ggcgagcagg atctggtcgc cctccttggt gaagacccgc tcgtggttgg ccttgtagtc
    30781 ctcctccagc cgcccgctgt tgaggacgct ggtgatcggc gcacactcgg gcttggcgcc
    30841 ggtgacggcg tcctcctccg cgccctgcga cttgtccatg ctcgtgttgg cctcgacctt
    30901 ccagccggca ggcagatcct cgagagcgac gagggcctgc tcggcctgag cggcggtgat
    30961 gtaggccggg accgacgggg cagcggaggc tttgcccttc ttggcttcag agctggagct
    31021 ggagccggag tcgccgttgc aggcggtcag gagcagcagc gacgaagcgg ccagagccgc
    31081 gagcacaacc cggcgaggac gaacgtgcac gaacgttccc ttcaatacat ttacgaatga
    31141 tacgtaagta tgcacatgct ggtgacaccc cttcacaggc cggtgcagac atggacggtc
    31201 cttcaaacga catggcctgc ctgcgtgaag tcgagtcggc ccaggaggtc atctgtggat
    31261 cgtgggccga gaccgagggc cggggccggg gccgaatact ccgttgcttg atcgaaggct
    31321 ggtcgacagc atgacgccca tgcgacgcca tgaacacgtc ggacccatgg cgctacgcgc
    31381 catgcaggac ctggccaccc gaaccttccc ggcgaccggc taccggcaca taggtgacct
    31441 cacctggaat tggtgtctgt ctctcggccg cgtcaatgaa tgcccgacgg cggtctggac
    31501 cgaaggaggc cgaacgctgg cctggggctg gctggaccta ccggacagtc tgatgctcca
    31561 agtcgacccg gaccacccgg aactggcgca cgacgtcctc gcttgggccg aacaagcggc
    31621 acccggcccg ctgcacgtcg aggtggccgg caccgaatca cacctggcca aagcgctgga
    31681 acagcggggg tacacgcagg ctgtcgacgg cccgttcatg gcatgcctcg accgttccct
    31741 caccgagctg ccggacgttc cccgcctgcc ggacggctat gcgatccgaa cccagcatga
    31801 cgacaccgac gtggccggcc gggcggccgc acaccgcgct gccttcggat cgacccgagt
    31861 caccaccgaa cgtcatgccc gcatgaggga cgcctggccc tatcgccccg aactcgacct
    31921 cggcgtgaca acgcccaccg gagacgtcgt ggcctactgc cagggctggt acgacgaggt
    31981 caacgcgacc ggcgcgttcg aaccagtcgg cacccatccc gaccaccgcc gtctgggact
    32041 ggcccgggcc gtctgcacgg cggtgctaca tgccttcgcc cgtgtcggtg gccggcgtgc
    32101 catcgtccgc tcgcggggcg atgccgccta tcccgtcccc aagcggctct acgaatccat
    32161 gggcttcacc acgtacaccc gcacgcatac cttcgtcggc aggccatcgg actgaggtgt
    32221 tctgcccggt gagccgggac cgggcaggag ccgccatggg tcagtcccga agggccttcg
    32281 gttcaccggt cccggcggtg ccgccacacg tcgtacagca gccagtagta cggcgacgtc
    32341 cggtcgacgg tgccgtcgag gccgtccagc agtgcgtcac cgcggtggtc gtcgcgcaga
    32401 gccagctgca ccgcggcggt gacccgtacg gcctcctcgg agtcggagag gcaggcggcc
    32461 agggcgtcgc agggggcggg gtcgtcggcc cgggcccgga gcagggtccg gcaggcggct
    32521 tcccggacct gggcatccgt gtcccgggtg caggccagga cggcggccag ggcgtcggtg
    32581 ttcgcctgct ggacctgccg gcccaggccg ccgaccgccc aggaccggac ctgggggtcg
    32641 gggtatcggg tgagggcggg cagcgtcctc ttggcgcggg agtccatcgc gtcggccagt
    32701 ccggcggcca ggggccgcat cacgcggggg tcctgctcct gctccaccca ggtgaggaag
    32761 aggtcgacga gcggggtgtc gaaggggggc tcctcgtcct caccgctttc gtcgtagagg
    32821 ttgatgcagc gcagcacgtc cgcgccgaag tagcgcgcca gcggatcggg gtggtgccga
    32881 agagcggctg cggcgtccca gacgggcggc agcgccgggc ccttgcgtcc ggcggccgcg
    32941 acgacggcct ccccccacac cgggtggtcg acctcgggtt cggccatggc ccggtccagc
    33001 agctcggtga agggcgtggc gattccgcag cacgattcca ggtgggtgag gatcgcggtg
    33061 tggccgtcgc ggacggtctg ctcgccgatc atcagttcgc ggcagatctc gccgttgccg
    33121 tcgcgcacgg tccgccggcg gacccccgct ccggtgccgg tcgtgtgcca gtggcgggcc
    33181 agtgcgagag cgtcacggcc ctcgcggtcc gtgacccggg ggtcggcccc ggcgaagtgc
    33241 agggcggtgg cgatgtcgtg ggcgccgcgg tcgacggcgc gcagcagggg cgtgcggccg
    33301 tcggcgtcga cgccgtccag gtccagcgcg tcgagatcgg ccagcttcag cagggcatcg
    33361 aggacccggt ggtcgagggc atccgcggcc aggcgcaggg cggctgcgac gtgcgggccg
    33421 cgcgcgtgag cggtgccgta ctcctcctgg agcagggcgg ccaccgcctg ggtgtcgccg
    33481 ttgcggacgg ccgtgaggag cgggtgttcg ggggaggtca tgcgcacagg gagcggagga
    33541 tcctttcggg gacgggggac gggggacggg ggacggggga cgggttacga ctgttcccgc
    33601 ggtagcaggt cacgggcggc ggcgaggtcg caggccgccg cgtccggctc gcgccgacgt
    33661 atcggtccca gatccgggca gcccatccgc ccatcatccc gtctcccttc accgaacccc
    33721 actggttaaa cggcacttaa cgcgcctgtg ccgagtcgcg gccagaaggg ccaccacgta
    33781 gaaccactgg cccggcgtcc cgtggttgag catgaccggg ccgatcggga ctccacggtc
    33841 ggtgccaggc ccagcgcatc cctgatgtcg gcggccgtgc gtgcccaacg ggcatgttcc
    33901 ggccacctgg cgcggtggtc ctccatctgg gccgaactcg cgccggcgag gaagcaggtg
    33961 agcccgtagt gcaattcttt gcgccagaag tccgtattcg tgcagcgtgc caccacggtc
    34021 gctgcgtgct gtgccagctt ggcacgtgcc ggttcggctg ccgagccgcg tccggcggcg
    34081 gccccccatc gtcatccggc tgggacgcct gcagcccggg tgagggtcag ctcagtggcc
    34141 cgcggggtga gctcttgtca gtgccgtatg acaaggtctg tcgcacgaac aaggaacgga
    34201 acgaggagtt cgggatgacg ggggcctggg acaaggcgcg cgtagtggag ctggcacgac
    34261 agctgagggg agcggagacc ggcggctgga gcgggccggc actgcgagca gtggtggaag
    34321 gtctcggctg gcagtgggaa gagggcgctg ccgggccgcg actggtcatg ggcacgcagc
    34381 cggacgcttc cccgcagtgg acgccccggc tgcgcccggt ggaccgcttc gagaaggact
    34441 atgtgcacgg cggcgaggag tacgtcgggc tgtatgtgcc cgtcgctctg ccggagggcg
    34501 gcgcggcggg gaaggccgcg gccttccggg aggttgccga ggcgctgacg gaagagttcg
    34561 gctctgccca catcatgggg gcatacggcg accccgggcc gttctacgac tccgccccgc
    34621 tgtggggcag tccgttcctc cgctggcgtg agcgggagaa cacgctggag ctgcacgccg
    34681 gcgagcacgg ccccgagctg ctgctccagc cgaccgatcc ggtggagaac tggttctggc
    34741 ggcagggaca cggtgaggac tacgccctcg gcgggttctt cggcagccga cgtgacccgg
    34801 ccaacgcggg cctgggcttc cccggccgct ggcgcaccga cgactgggac gtcttctccc
    34861 acaccctcgg cgacttcctc ggcactctcc ccgccgagac ccacgctctc ggcatcgagc
    34921 tggacttcgg cttccacgct ctggtgcccg gtacctatgg cccgatcttg ttcaacctcc
    34981 tctgcggcga acgactggag atcatctacg acccggagcg actcggagag ggcgtcaccg
    35041 atccgagctc cttcggctgg atcccgcacg ccacccgccc ggccgccctg gaccactggc
    35101 acgaggcccc cttccactcg ggggacttcg gcatcggcga ggtggacggc cgccgactgg
    35161 cccgcatgat ggtcgacacc ctgcgcgacc tgggcgtctc ctccccgaag gacctcagcc
//
