LOCUS       NZ_LNBE01000003        22607 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_3, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000003
VERSION     NZ_LNBE01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2630732)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1942326
            Orig. end                         :: 1964933
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22607
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="18"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22607
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22607
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12607](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12607)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    202..221
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.45"
                     /tool="antismash"
     misc_feature    complement(650..662)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    927..945
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.6"
                     /tool="antismash"
     gene            1009..1737
                     /locus_tag="AS857_RS14170"
     CDS             1009..1737
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990943.1"
                     /locus_tag="AS857_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_058043452.1"
                     /transl_table=11
                     /translation="MTRGDGAGAAGVDPQQLWLTPGRSGRGRKPAFSRRAITAAAVALA
                     DAEGLEAVTMRRVAAQVGAGVMSLYNYAPDKETLLELMVDHVSGELPATDPLTGDWRTD
                     LKAIGHLQRALMLRHPWLPAALSARRSLGPHTLAFLERALAALRPTRLDGAAKLEVFAQ
                     LTGFVAAHVAHEIAQAATAQAPDRAAAEARYLAAVAADGHHPELAEALAAPGRPLTPEA
                     TFTRFLDRLVDGLDTDPDAD"
     gene            1817..3253
                     /locus_tag="AS857_RS14175"
     CDS             1817..3253
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655952.1"
                     /locus_tag="AS857_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_063804250.1"
                     /transl_table=11
                     /translation="MSEDILYGLAGNPAAPPDVLLRLLRSESPDTGERVARRADLPDEV
                     IDAIVSHPDVKVRSAFAESPLAPGAQRARLVGDKPKVRLALAAGPLIFRRRPEPLPDET
                     YERLFNDPRPIIRHEALMSPSLPARVLAGLADSPDPDLRHAACRAWHELTPEAREALLA
                     DEEPYVRRAAALRAAPGDVRHAAELVGELDRWDLALLLTHGRLDRGLAERYAHSDEPSE
                     RMAIAENPSLPTDLVAHLARDPHHPVRLAVSARPELTETQRAAIDYEIGPGDRLRPLLW
                     VWEAREDADVMRRCVHSSHIWLRRSAAVSPHLPPDLVARLARDDDFAVRLLLCEHHPAP
                     PPELMWRILLEWDGYTRWWLLDKPGFPLHRLAALAHHEDPGLRRFALRAPDASPELLDR
                     LSRDEVGYVRHEAAGDPRLPLPRLHELLADPANACYAAQNPALSTAEMRRLLDEAGLAV
                     QTTRGASSGAVAAGGPVTGC"
     misc_feature    complement(1818..1832)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(3240..4019)
                     /locus_tag="AS857_RS14180"
     CDS             complement(3240..4019)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386801.1"
                     /locus_tag="AS857_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058043453.1"
                     /transl_table=11
                     /translation="MTWAHLRHGPAHQPYAHHPPAASAVDLSKVYGSGARRVAALDGVS
                     VAFQQGQFTAIMGPSGSGKSTLMQCLAGLDTPTSGRALIGDTDLAGLSERRLTRLRRER
                     IGFIFQAFHLLPALTVAENITLPLAITGRRPDRQWLDQVVTTLGLTDRLGHRPGELSGG
                     QQQRVACARALAGRPDIVFADEPTGNLDTPTSAEVLSLLAHLTHRMGQTIIMVTHDPAA
                     AAYTDRVVFLADGRITDELHHPDADRILDRMKRFNNL"
     gene            complement(4016..6211)
                     /locus_tag="AS857_RS14185"
     CDS             complement(4016..6211)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="AS857_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_144440810.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 4e-43, bitscore:
                     144.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADSVPVAGEGTRPDGRTGEPADPYRWLEENSSRTRAWLTTQQHL
                     LEAHRERTDDRGWQSLLHRIETATSGRLLNPPVEAGGMLFRQVLSASGSELLTATDPHG
                     RTRTLLDTGDRPSPTRTAGWHPDPHGRALLVQLHHDGHENGGLHLIPTDGTAPAAYLPD
                     ASPHPAVAYADGLLLYSAGTRTEHTLHARPLRDDPARSAARHPHRTVELPVPGPARITL
                     HCGPGGHLLLRTRTAKAPSAQWWCTLWDGHGTPDWQPLPLDDLRITAFALGASHLYLAT
                     GREVSALALPDAARGHITAPAPLPRPADAGPTPGEVKAMRVLGPGPYPCLAVLRQHGTT
                     RRLSLLGTLGMQPTHGMRAEDGVPAEPTTEAGSRGTTVLTWHARLRIGPASYGDDGRPG
                     DALWILADDPRDGCWSHRLTPGAPPVAPPAGHSPLRTSTAVSSDGTSLPVTICDPPSAG
                     TGPAPVLVTVYGGFGVPLEPSWDPILAAWLTAGGRVAWVHARGGGEFGPEWAAAGRGAG
                     KSRTVDDLCAAARALVDQGEAGPGQLAALAASNGGLVLAAAVLRAPRLFSAVACAAPLT
                     DMARYTSGGGLGRLWHDEYGDPADPAAMAALLAYSPCHHVRQGESYPATLLITGGNDAR
                     VPPWHAWKLCAALQEATAARQPVLLDHQPDTGHHGRTGTAATALSARVLALLATRTGLA
                     APTRPDPPSPATDVNAPSPLRALRQPTAPAPSLRSTA"
     misc_feature    complement(5630..5632)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6204..7505)
                     /locus_tag="AS857_RS14190"
     CDS             complement(6204..7505)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="AS857_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_058043455.1"
                     /transl_table=11
                     /translation="MKQPKQKLGRRFWLLFSGEAASAVGTAASVIALPMVAYQVSGDVR
                     HAGFTSTALSLGIVVARLPAGVLADRYERRTLLLLGNAVGALVLGTLAVLRAAGSVHPG
                     ALLAAAFLLGAVGSTLAPVENVAVRTFVRADLLPRALALIQSRAALALIVGPLVAGVLL
                     KANAAWVFAADALTYLTAACCAFLLPAKAGPTGGQQPALRAVTEGLRFLWRSPFLRYGA
                     LNATVLNLVFNGLLIVVIASCDRTGAGSVAVGVQTACFGAGAVAGSLIAAPVARRLPAG
                     RGIALATAVIALALLGFATVRSTWGAALMLAIATAGGPVITVVLSSMQMRITPPQLQGR
                     VHSASGFLSQAVAPLGPTLAGASAHAFGLGPTVTAAAALVVLLAVVGWFTTARRTVAAE
                     AQQSLDAQVATDAQEARVGEVPPVEAPTVEASRG"
     gene            complement(7502..9424)
                     /locus_tag="AS857_RS14195"
     CDS             complement(7502..9424)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="AS857_RS14195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_058043456.1"
                     /transl_table=11
                     /translation="MRRLFLAEARAYPGRLAGAAMACAMTAAGVGACTLLLIGAGRADF
                     PARSVAATQAQDARNLLSLLLSILLMCAVLVIGSTVSLWTGQRLGQFAVLRALGVTAGR
                     LRRLVAGDVARLAIAAAAVGALGMLPLAHAGRRLLVNRELFPEAASLPSTGQVWGTALG
                     VCIATGAVAVLAAMASVFAAGRVGPGALLKDTEGALASRRSRARLLTGLTMAVMLCVPL
                     LYVMAFTQLPSTVRAAVAPGLALVLIPTLAVLAPWIVPLLTRPVCAVLRIADRRVGRIA
                     AAGLRAAPARTTAMAVPVLLAVGIAVCLLGTGATMGEAVARQTGDGLRADGVVTARPGH
                     RLPAQPAASSGGPGALSGVTATVLVSTRITAPPTSFDDQPSPVDAWGADGSALVQSLDL
                     KEREGRLSALREGTFAAGVGQAEAHHWRLGQKVRLALADGSRPELTLVAVYERDLAFPA
                     FVIARTTALQHTREPYADRILLSGAYRSWSKETGQTVASRAQYLDDLKPRNPADDLASR
                     LIVSVVSGYALLAAANTASLAQRDRRAQRAHLRALGLSRGQLLRCVLYEAFGAAAVGAA
                     LAAATAVACLVPFAASLGTGALPALDVPWTAAVLAAAALAVALPSVMTAHPMSTVRQQF
                     ARRAA"
     misc_feature    complement(9543..9554)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.59"
                     /tool="antismash"
     gene            complement(9583..9672)
                     /locus_tag="AS857_RS40635"
     CDS             complement(9583..9672)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="AS857_RS40635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_216823968.1"
                     /transl_table=11
                     /translation="MLNVLALQELDEETVLDAPLSSVSVVVCH"
     misc_feature    complement(9658..9673)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.31"
                     /tool="antismash"
     gene            complement(9739..9828)
                     /locus_tag="AS857_RS40640"
     CDS             complement(9739..9828)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="AS857_RS40640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_216823969.1"
                     /transl_table=11
                     /translation="MQNILALQELDEETIVDAPISTISLGGCH"
     CDS_motif       complement(9772..9828)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQNILALQELDEETIVDAP"
                     /locus_tag="AS857_RS40640_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9739..9771)
                     /prepeptide="core"
                     /locus_tag="AS857_RS40640_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-2.10"
                     /molecular_weight="933.1"
                     /monoisotopic_mass="932.5"
                     /core_sequence="ISTISLGGCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQNILALQELDEETIVDAP"
                     /leader_location="[9771:9828](-)"
                     /alternative_weights="951.1"
                     /alternative_weights="969.1"
     misc_feature    complement(9824..9837)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.0"
                     /tool="antismash"
     misc_feature    complement(9890..9902)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(9893..9982)
                     /locus_tag="AS857_RS40645"
     CDS             complement(9893..9982)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="AS857_RS40645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_206329932.1"
                     /transl_table=11
                     /translation="MLNILALQELDEETVLDAPLSSVSVVVCH"
     misc_feature    complement(9968..9983)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.43"
                     /tool="antismash"
     gene            complement(10001..12607)
                     /gene="lanKC"
                     /locus_tag="AS857_RS14200"
     CDS             complement(10001..12607)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="AS857_RS14200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_058043457.1"
                     /sec_met_domain="micKC (E-value: 1.6e-195, bitscore: 648.7,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 7.5e-13, bitscore: 45.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPRYETYTIADSTWYEPLDRCQDSDSLVSLSVRELPEGWRREHQ
                     GVWQFLTPGDAAKLPEQGWKIHVSATPGAAEETIEAAWNVCRRLGLPWKFLRSRQIVAA
                     MNTKYAHRAASGKTVTVYPRTTDELRTALEELETAMRGRPGPYVLSDRRWNDGPVSVRY
                     GAFTLMWCELADGTRVPAMRTPQGQLVPDPRRPVFTVPPWADVPDFLAEQPAADGAPAS
                     LGGYEVRKALHFSNGGGVYLAADGHGGQVVLKEARPHAGLDANGLDAVARLRTEDAVLG
                     RLGHLPFVPRRYGSFTAWEHHYLAMEYVEGETVSAWLGREHPLTRHRPAAAARSRFAAS
                     VVERMEQVAGCVRALHEAGVAFGDLHHRNILIRPDGTVALVDFELAAPLDSVRSAALGA
                     PGFADPALTDPREADLFALGCCQLAALVPLTVLTLRNPRVVASLIGLARASFPSLPAEF
                     VRQMTELLALSPTLRPHLPPPGTPAGTPAGAPGGIPTDPPTLTAPTAPTAETLLQGISR
                     SADPGRKDRRYPCDVAGYRPGASMGLAYGTPGVLWARHAAGSTVSGEDVEWLANTALRA
                     PLDAPPGLYDGLAGAAWILHRLGHPQGANLVDRLLAGPLPASPGLFGGLSGIAHLFLDV
                     GLKDEALALALRVRERVGVKGLLDRPGLMYGWSGPAVLLARCAEVTGDLQWAAAAERAV
                     RCDLVHARDVDGMLQMHSSSRLLPYLAEGSAGVAMAALALPPPQAAAVGADGIVAGAAR
                     AGAVEVVLQGGLFNGRSGLAYLLSHAPARTGRWRAELDSHLRALSLHLAPYEDAHVLHG
                     DQLVRLSADLATGSAGAVIALVAAQNPGSRLLPGAHPTCGWPPAGSDAPDHPAPQA"
     misc_feature    complement(12654..12668)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.76"
                     /tool="antismash"
     misc_feature    12662..12673
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            complement(12972..13748)
                     /locus_tag="AS857_RS39965"
     CDS             complement(12972..13748)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.4"
                     /locus_tag="AS857_RS39965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_160330227.1"
                     /transl_table=11
                     /translation="MSVHSAVQDFQQMAVAPHWGRIRAYLGEVRDTLRDIMCRDGVEVL
                     LDSLGPGIRWNAPALEIAGVRSGERELDGSGLVLAPSLFLQRAGHVLPPARQGAHRAPV
                     LVFPDRPGPEELTRLLGGGRAAGPQCGPDSLAALVGRTRAAALRALREGCTNAELAERL
                     GVSAAAVSQHMAVLRAAGLVSTRRNRSHAIHTVTRLGHLLLRGEAAERHPAEQHPAEQH
                     PTERHATERHAAEPVLRGAALPQARDRRTPAAAVAL"
     misc_feature    complement(13916..13927)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.07"
                     /tool="antismash"
     gene            14598..14963
                     /locus_tag="AS857_RS40650"
     CDS             14598..14963
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS40650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216823970.1"
                     /transl_table=11
                     /translation="MPITLDEEEIGAVWLERPGPPGPPGPPGPFDDLLLDRLAIAVAAV
                     VERHGPAFTTMADPALVELVISPGSDEAARARALRLMGFSAGLPVRVAAVRSEIPLDHV
                     GGSICATRPVKAAKSPE"
     gene            15104..15409
                     /locus_tag="AS857_RS40655"
     CDS             15104..15409
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007261986.1"
                     /locus_tag="AS857_RS40655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_245699825.1"
                     /transl_table=11
                     /translation="MHYDGLGALALLAEIPQDLSRDNADVAAIARMAGSPDDLETLDAY
                     CTTGSLRRAADLLHLHHSSVARRLDHIGTTLGIGLTEPAGLVRARLALTAWRLHGD"
     gene            15675..16763
                     /locus_tag="AS857_RS14215"
     CDS             15675..16763
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607540.1"
                     /locus_tag="AS857_RS14215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_058043459.1"
                     /transl_table=11
                     /translation="MNRDLTLHDIIVAGIAVAAGLAVALVLRVVLRWLGVRALRTRWQG
                     DDIIVDVLRTLAPGCAVAGGVAAAAGALPLTRQVGHVVDEVLMGAVVLIATFTAARVIS
                     GLVRSMAQSRSGVAGSATIFVNITRIAVLALGFLVMLETLGISIAPLLTALGVGGLAIA
                     LALKDTLANLFAGVHILVSKTVQPGDYIRLSSGEEGYVRDINWRITVVEQLNNNLVIIP
                     NAKLAGTNMTNFSRPEQKLAVTVQVGVGYESDLERVERITVEVAESVMKDVDGADPDYE
                     SAVRFHTFGDSRIGFTVILGVGEFSDKYRIKHEFIKRLHQRYRAEGIRIPAPARTVSLQ
                     QAEGTTTETTIPHPRASLDQAS"
     misc_feature    complement(16880..16893)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.54"
                     /tool="antismash"
     gene            17092..17436
                     /locus_tag="AS857_RS14220"
     CDS             17092..17436
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS14220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_058043460.1"
                     /transl_table=11
                     /translation="MRSTVSAYARLPKIHKFSVAGIAATGAAVVAVAVAPHAFAADAAP
                     AAAVKPVAWSAEAFGETQQAELDKHVDAAAKAGAEAAAVKPVAWSAEAFGETQQAELDK
                     HVDAAAIRRR"
     gene            <17777..>17956
                     /locus_tag="AS857_RS41330"
                     /pseudo=""
     CDS             17777..>17956
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004944770.1"
                     /locus_tag="AS857_RS41330"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="lytic transglycosylase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MISESLDILRAKGIPASYDGIKRNIMRESTGNPRAINDWDINAVN
                     GVPSKGLLQMIDPTF"
     gene            complement(<17953..>18078)
                     /locus_tag="AS857_RS41335"
                     /pseudo=""
     CDS             complement(<17953..18078)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989298.1"
                     /locus_tag="AS857_RS41335"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="lytic transglycosylase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPLDILRAKGIPASYDGIKRNIMRESTGNPRAINDWDINAVN"
     gene            complement(18310..19416)
                     /locus_tag="AS857_RS14225"
     CDS             complement(18310..19416)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174492.1"
                     /locus_tag="AS857_RS14225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_058043461.1"
                     /transl_table=11
                     /translation="MRIQFLPAGPDPAGPRRALIAAPVVLIAVIMAVDLVTGPDIHLGP
                     LLVAAPALTATFGGKRLTAFIGALAVGAQIALGFIFGRATTADHQTQTGALFLAVCFIV
                     AFHALRERHEQALDRAWGIADAAQKVLLRPLPSRIGPLELASEYAAAEAEAQIGGDLYA
                     AVRARDATRVMIGDCRGKGLPAVGDAALLLGAFRAAAHRFPPLPRLVAHLHNTVYWDAE
                     EPADELAAGESFVTAAVLEIPDDRPLLHLISCGHPPPLIVRDGEVVTLAVSDPDLPFGL
                     GTPTTEADYEPEAFAFRDGDLLLLYTDGVIEARDPHGTFYPLAERLASWNEREPQRLIQ
                     RIRQDLLAHAGGALDDDVAMVAIRRSPV"
     misc_feature    complement(19525..19540)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.12"
                     /tool="antismash"
     gene            <19557..19667
                     /locus_tag="AS857_RS41340"
                     /pseudo=""
     CDS             <19557..19667
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104878.1"
                     /locus_tag="AS857_RS41340"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="e9imm peptide"
                     /pseudo=""
                     /transl_table=11
                     /translation="CPSGHVGDLIFWPPGLVELSAEEVVDRALEYRPITL"
     gene            complement(19761..20228)
                     /locus_tag="AS857_RS14230"
     CDS             complement(19761..20228)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS14230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_058043462.1"
                     /transl_table=11
                     /translation="MSKRTTTLLAAAALSVVALAGQAGAAETSGHAAPAAASAAAEPGV
                     QATRTVHAPFTLEQNQSLTSDTANLVMQSDGNLVIYDEFGRARWASRTVGQGWRAAFQE
                     DGNFVVYTRSGKAVWSSRTAGHPGSRLVVQDDGNVVIYDGSQAIWDSGTNH"
     misc_feature    20294..20309
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            complement(20358..20990)
                     /locus_tag="AS857_RS14235"
     CDS             complement(20358..20990)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105601.1"
                     /locus_tag="AS857_RS14235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_058043463.1"
                     /transl_table=11
                     /translation="MESRSADPGTVRPGGRTARVRAAVLQAAGDALAEGGLSGLDLADV
                     ARRADVGRTTVYRRWGTPAALVADLLADMAEQSLPRARTGTLQGDLRTNARLVQRTLAD
                     PRQGALFKAVIAAATCNDEAASALRLFYATRVTEWEPCVREAVERGELPEGTDTREVVR
                     AVSAPLYYRLLTTGEALDEAAADRAAAAAISAAQAGAFVTAEAPAKH"
     misc_feature    complement(20969..20986)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            21132..22196
                     /locus_tag="AS857_RS14240"
     CDS             21132..22196
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742183.1"
                     /locus_tag="AS857_RS14240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_058043464.1"
                     /transl_table=11
                     /translation="MEFRRLGASGLMVPALSMGAGTFGGRGELFGAWGDTDAEEARRLI
                     DICLEAGLNMFDTADVYSAGASEEVLGAAIKGRRDEVIISTKAGLPMGDGPADAGTSRS
                     RLIKAVEDALRRLGTDYIDLFQLHAFDAGTPVEEVLSTLDDLVRAGKIRYTGVSNFAGW
                     QLMKSLGTADKHGYQRYAAHQVYYSLIGRDYEWELMPLGLDQGVGAVVWSPLGWGRLTG
                     KIRRDKPLPAGSRLHATADYGPPVDDELLFRVVDTLDEIALETGKTVPQIALNWLLQRP
                     TVSSVIIGARNEAQLRQNLGAVGWNLTADQVARLDAASATTAPYPYFPYERQEGFARLN
                     PHPVRRGAGAAGEA"
ORIGIN
        1 agggaggttt cgcacccggc ccggcgcagc cgggcgtact gctcgagggt ctggtcggcc
       61 agggcgtcgt gccagccggt gatcaggccg gtgggcacgc tcagccgctc cgctgcctct
      121 cccggggacg cgccgtccca gtagggatcg ccggcgtccg ggtgcgtcat cacgtcgtcg
      181 agccagggca cctctccgag ggcgggcacg tgcgccccgc gcagcggccg cgcggtggtg
      241 atctcgcgca tgcgccgctg caggcgcagt gccgccctca cgaaggggac gatcccccgg
      301 tgctggtacg tcatgccgac gccgacggtg agggcgttct ccaggcggag cgcgccgtcc
      361 gcgtggaaga gggcgtaggg gtcgtgcagg ccgacctgga ccaccatcgc cttgagctcc
      421 ggcggcgggt ccagggcaag ggcccactgc acgtagccga ggtagctggg tccgacggtg
      481 cccagggtgc cggtgaacca gggctgctcc cgcagccagg acaccgcggc ccggccgtcg
      541 gcggcctcgt tgcgccacag gtcgaaccgg ccgcccgagc cgccggtgcc gcggcagctc
      601 tgcaggacca cgtggaagcc ctgttcggcg aagagcaacc cgtacatcgg tgaccacggc
      661 actcccctgc cgtagggcga acgcacgagc aacgtgggga agtcgccctc ggtgcggggg
      721 aagtagtggt cggtgcgcaa ggtgctgccg tccgcggccg gtaccgacag gcccggttcc
      781 cagccgactt cgtgctgtgc ggccggcagg ccgcgccacg tcgccctcat cagccgggag
      841 ctgagcggcg gcttcccgga cggtgcgccc cagacggtcc tcggggcggc atcgtgcgca
      901 tgcggtgtca tcgtgttccc ctcactcatt tacgtacagt gtacgagaat agagggtgct
      961 tggatggttt ccgcaagtcg cagtggcaaa gagaggggcg aggagaacgt gacccgtgga
     1021 gacggcgccg gcgccgccgg agtcgacccg cagcagctct ggctgactcc cggccggtcc
     1081 ggcagagggc gcaaaccggc cttcagccgc cgggcgatca cggccgcagc cgtcgccctg
     1141 gcggacgccg aagggctgga agcggtcacc atgcggcgcg tcgccgccca ggtcggagcc
     1201 ggcgtcatgt cgctctacaa ctacgccccc gacaaggaga ccctgctgga actgatggtc
     1261 gaccacgtca gcggtgagct cccggccacg gatcccctca ccggagactg gcgcaccgac
     1321 ctcaaggcca tcggccacct gcagcgcgcc ctcatgctcc ggcacccctg gctccccgcc
     1381 gcgctgtccg cccgccggtc cctcggcccc cacacgctgg ccttcctgga acgcgcactc
     1441 gccgccctgc ggccgacccg gctggacggc gccgcgaagc tggaggtctt cgcccagctc
     1501 accggattcg tcgccgcgca cgtcgcccac gagatcgcgc aggccgcgac cgcacaggca
     1561 ccggaccggg ccgcagccga agcccgctat ctcgccgccg tcgccgcgga cggccaccac
     1621 cccgagctcg cggaagccct cgccgcaccc ggacggcccc tcacccccga ggccaccttc
     1681 acccgtttcc tcgaccgtct cgtcgacggc ctcgacacgg accccgacgc cgactgagac
     1741 ggcgcctcga gggcaccgcc ccctcacctg ctgcgccggt gatccaccga cagcccatcg
     1801 accgaccgga gagcccgtgt ccgaagacat cctgtacggc ctcgccggca accccgccgc
     1861 ccctcccgac gtgctcctgc gcctactgcg atcggaaagt cctgatacgg gggagagggt
     1921 ggcgcggcgg gcggaccttc ccgacgaggt gatcgacgcg atcgtgagcc accccgacgt
     1981 gaaggtccgg tccgcgttcg ccgaaagccc gctcgccccg ggcgcgcagc gggcacgcct
     2041 ggtcggtgac aagcccaagg tccggctggc cctggccgcc ggccccctga tcttccggcg
     2101 ccggcccgag cccctgcccg acgagaccta cgagcgcctg ttcaacgatc cgcgcccgat
     2161 catccgccac gaggcgctga tgtcgccgtc cctccccgcc cgcgtcctgg cgggcctcgc
     2221 cgacagcccc gacccggacc tgcgccacgc cgcctgccgc gcatggcacg aactgacgcc
     2281 cgaggcccgg gaggcgctgc tcgccgacga ggagccgtac gtacgccggg ccgccgccct
     2341 ccgcgcggca cccggcgacg tgcgccacgc cgcggagctc gtcggtgaac tcgaccgctg
     2401 ggacctcgcc ctcctgctga cccacggccg gctcgaccgt ggcctggccg aacgctacgc
     2461 gcacagcgac gagccgtccg agcggatggc gatcgccgag aacccctccc tccccaccga
     2521 cctggtcgcc cacctcgccc gggaccccca ccaccccgta cgcctcgccg tctccgcccg
     2581 cccggagctc acggagaccc aacgcgcggc catcgactac gagatcggcc ccggcgaccg
     2641 gctgcgtccg ctgctctggg tctgggaagc ccgcgaggac gccgacgtca tgcgtcgctg
     2701 cgtccactcc tcccacatat ggctgcgccg cagtgcggcc gtcagcccgc acctcccgcc
     2761 cgacctcgtc gcccgcctcg cccgcgacga cgacttcgcc gtccggctcc tgctgtgcga
     2821 gcaccatccg gcaccgccgc cggaactcat gtggcggatc ctcctcgagt gggacggcta
     2881 cacccgctgg tggctgctgg acaagcccgg cttccccctg caccgcctgg ccgccctcgc
     2941 gcaccacgaa gaccccggac tgcgccgctt cgccctccgc gcccccgacg cctcacccga
     3001 actgctcgac cggctcagca gggacgaggt cggctacgta cgccacgagg cggccggcga
     3061 tccgagactg cccctgcccc ggctgcacga actgctcgcc gaccccgcaa acgcgtgcta
     3121 cgcagcccag aacccggccc tttcgacagc cgaaatgcgc cggctcctcg acgaggcggg
     3181 cctggccgtc caaacgacaa gaggtgcgtc gagtggcgcc gtcgcggccg gcggtccggt
     3241 cacaggttgt tgaagcgctt catccggtcc aggatccggt cggcgtccgg gtggtggagt
     3301 tcgtcggtga tgcggccgtc ggccaggaag acgacgcggt cggtgtaggc ggcggccgcc
     3361 gggtcgtggg tgaccatgat gatggtctgc cccatgcggt gggtcaggtg ggcgaggagg
     3421 gagaggactt cggcgctggt gggggtgtcg aggttgccgg tgggttcgtc cgcgaagacg
     3481 atgtcgggcc ggccggcgag ggcccgggcg caggcgacgc gttgctgctg cccgccggac
     3541 agttctccgg ggcggtggcc gagccggtcc gtgaggccga gcgtggtgac gacctgatcg
     3601 agccactgcc ggtccgggcg ccggccggtg atggccaggg gcagggtgat gttctccgcc
     3661 acggtcaggg cgggcaggag gtggaacgcc tggaagatga acccgatccg ttccctgcgc
     3721 aggcgggtca gccggcgctc ggagaggccg gccaggtcgg tgtcgccgat gagggccctt
     3781 ccggacgtgg gcgtgtccag tcctgcgagg cactgcatga gcgtggattt gcccgacccg
     3841 gaggggccca tgatggcggt gaactgcccc tgctggaatg ccacgctcac accgtcgagg
     3901 gctgcgacgc ggcgtgctcc gctgccgtac accttgctga ggtccaccgc ggaagcggcc
     3961 ggcggatggt gtgcgtaggg ctggtgtgcc gggccgtggc gcaggtgtgc ccaggtcatg
     4021 cggtgctcct caaggacggt gcgggtgcgg tcggctgccg gagcgcccgg agcggggagg
     4081 gcgcgttcac gtcggtggct ggcgagggcg ggtccggtct cgtgggtgcg gcgaggccgg
     4141 tgcgggtggc gaggagggcc aggacgcggg cgctgagggc cgtggcggcg gtgccggtgc
     4201 gcccgtggtg gcctgtgtcg ggctggtggt ccaggaggac gggctgccgg gcggcggtcg
     4261 cctcctggag cgcggcgcag agtttccagg cgtgccaggg agggacccgt gcgtcgttgc
     4321 ccccggtgat caggagcgtg gccgggtagg actcgccctg ccgtacgtgg tgacaaggcg
     4381 agtacgccag gagcgctgcc attgcggccg ggtcggcggg gtccccgtac tcgtcgtgcc
     4441 acaggcggcc caggccgccg cccgaggtgt agcgggccat gtcggtgagg ggcgcggcgc
     4501 aggcgacggc cgagaagagg cgaggggcgc ggagcaccgc tgcggccagc accaggccgc
     4561 cgttgctcgc ggccagtgcg gcgagctgtc ccgggcccgc ctcgccctgg tcgacgaggg
     4621 cgcgcgcggc tgcgcacagg tcgtcgacgg tgcgcgactt gcccgcgccc cgccccgccg
     4681 ccgcccactc cgggccgaat tcgccgccgc cccgggcgtg gacccaggcc acgcgcccgc
     4741 cggcggtgag ccatgcggcg aggatggggt cccaggaggg ttcgaggggg acgccgaagc
     4801 cgccgtagac ggtgaccagg accggggccg ggccggtgcc ggcggagggc gggtcgcaga
     4861 tggtgacggg gagggaggtg ccgtcgctgc tgacggcggt cgaggtacgg aggggggagt
     4921 ggcctgccgg cggggcgacg ggtggtgcgc cgggggtgag gcggtggctc cagcagccgt
     4981 cccgcgggtc gtcggccagg atccacagcg cgtcgccggg acggccgtca tcaccgtacg
     5041 aggcaggtcc gatgcgcagc cgggcgtgcc aggtcaggac cgtggtgccc cggcttcccg
     5101 cttcggtcgt cggctcagca gggactccgt cctcggcacg catgccgtgg gtgggctgca
     5161 tgccgagcgt gccgagcagg ctgaggcgcc gggtggtgcc gtgctgcctc aggaccgcca
     5221 ggcacgggta cggtcccggc cccaggacgc gcatggcctt gacctctcct ggcgtcggcc
     5281 cggcatcggc ggggcggggg agcggggcgg gggccgtgat gtgcccgcgg gccgcgtccg
     5341 gcagggccag cgccgagacc tcccggcctg tggcgaggta gagatggctc gcgccgaggg
     5401 cgaacgcggt gatacggagg tcgtcgaggg gaaggggctg ccagtcgggc gtgccgtggc
     5461 cgtcccagag ggtgcaccac cactgtgccg agggcgcctt cgccgtccgg gtgcgcagca
     5521 gcagatggcc tccgggcccg cagtgcaagg tgatcctcgc cggtccgggg acgggaagtt
     5581 ccacggtccg gtgaggatgc cgggccgcgc tccgggccgg gtcatcacgt aacgggcggg
     5641 cgtgcagggt gtgttcggtg cgggtgccgg cgctgtagag caggaggccg tcggcgtagg
     5701 ccacggcggg gtggggtgag gcgtcgggaa ggtacgccgc gggtgcggtg ccgtcggtgg
     5761 ggatcaggtg gaggccgccg ttctcgtgcc cgtcgtggtg gagctggacg agcagggcgc
     5821 ggccgtgggg gtcggggtgc cagcccgccg tcctggtggg ggaggggcgg tcgccggtgt
     5881 ccaggagggt gcgggtgcgg ccgtgcgggt cggtcgcggt gaggagttcg ctgccggagg
     5941 cgctcagcac ctgccggaag agcatccctc ccgcttccac cggtgggttc aggaggcggc
     6001 ccgaagtggc ggtctcgatc ctgtgcagca gcgactgcca gccgcggtcg tcggtgcgtt
     6061 cccggtgggc ttccagcagg tgctgctgcg ttgtcagcca cgcgcgcgtg cgtgacgagt
     6121 tctcctccag ccagcggtag ggatccgccg gttcaccggt ccgcccgtcc ggccgggtac
     6181 cctcaccggc cactggcacg ctgtcagcca cggctcgcct ccaccgttgg agcctccacc
     6241 ggcggcacct ctccgacgcg ggcctcctgt gcgtccgtgg ccacctgcgc gtccagggac
     6301 tgctgcgcct ccgccgccac cgtacggcgg gcggtggtga accagcccac cacggccagg
     6361 aggacgacca gggcggccgc cgccgtgacc gtcggcccca ggccgaaggc gtgtgcgctc
     6421 gctccggcga gcgtgggccc gagcggggcg acggcctggg agaggaagcc gctggcactg
     6481 tggacgcgcc cctgcagctg cggcggcgtg atgcgcatct gcatcgagga gagcaccacc
     6541 gtgatcacgg ggccgccggc ggtggcgatc gccagcatga gggccgcgcc ccacgtactg
     6601 cggaccgtgg cgaagccgag cagcgcgagg gcgatgacgg cggtggccag ggcgatgccc
     6661 cggcctgcgg ggagtctgcg cgccaccggg gcggcgatca gggatccggc caccgcgccc
     6721 gcaccgaagc aggcggtctg cacgcccacg gccaccgagc ccgcgccggt cctgtcgcag
     6781 gaggcgatga cgacgatcag caggccgttg aagacgaggt tgaggacggt ggcgttgagc
     6841 gcgccgtagc gcaggaaggg ggaccgccac aggaagcgca ggccttcggt gacggcccgc
     6901 agcgccggct gctgcccccc ggtggggccc gctttggcgg ggaggaggaa ggcgcagcag
     6961 gccgcggtga gataggtcag ggcgtcggcg gcgaagaccc aggcggcgtt ggccttgagc
     7021 agcacgcctg ccacgagagg gccgacgatc agtgcgagtg cggcacggct ctggatcagg
     7081 gccagggcgc gggggagcag gtcggcccgg acgaaggtgc gcacggccac gttctcgacg
     7141 ggggccaggg tgctgcccac ggcgccgagg aggaaggcgg cggccaggag ggcgcccggg
     7201 tggacggagc ccgccgcacg gagcacggcc agggtgccga gcaccagggc gccgacggcg
     7261 ttgcccagga ggaggagcgt ccggcgttcg tagcggtcgg cgagcacccc ggcgggcagc
     7321 cgggccacca cgatccccag ggacagcgcg gtactggtga atccggcgtg ccggacgtcg
     7381 ccgctcacct ggtaggcgac catgggcagg gcgatgaccg aggccgccgt gcccacggcg
     7441 gaggcggcct ccccgctgaa cagcagccag aaccgcctgc ccagcttctg cttcggctgc
     7501 ttcacgccgc cctccttgcg aactgttgcc ggacggtgga catcgggtgg gcggtcatca
     7561 ccgagggcag ggcgaccgcc agggcggcgg cggccaggac cgcggcggtc cacggcacgt
     7621 ccagggcggg cagcgccccg gtgcccaggg acgcggcgaa ggggaccagg caggcgactg
     7681 ccgtggcggc cgccagcgcc gccccgacgg cggccgcgcc gaacgcttcg tagagcacgc
     7741 agcgcagcag ctggcctctg ctcagcccga gggcgcgcag gtgggcgcgc tgggcgcggc
     7801 ggtcgcgctg ggccagggag gcggtgttgg ccgcggccag cagcgcgtag ccgctgacga
     7861 cggagacgat caggcgcgag gcgaggtcgt cggcggggtt gcggggcttc aggtcgtcga
     7921 ggtactgcgc gcgggaggcg acggtctgac cggtctcctt cgaccaggag cggtacgcac
     7981 cgctgagcag gatccggtcg gcgtacggtt cccgggtgtg ctgcagggcc gtggtgcggg
     8041 cgatgacgaa cgccgggaag gcgaggtcgc gttcgtagac ggcgacgagg gtcagctcgg
     8101 ggcgggaccc gtccgccagg gcgagccgga ccttctggcc gagccgccag tgatgggcct
     8161 ccgcctggcc gacgccggcg gcgaacgtcc cctcccgcag cgccgacagc cggccttcgc
     8221 gttccttgag gtccagggac tgcacgagcg cggaaccgtc ggccccccag gcgtccacgg
     8281 gagagggctg gtcgtcgaag gacgtgggag gcgcggtgat ccgcgtggac accagcaccg
     8341 tggcggtgac gccggagagc gctccgggcc cgccggagga cgcggcgggc tgcgcgggaa
     8401 ggcggtgccc ggggcgggcg gtgaccacgc cgtcggcgcg cagcccgtcg cccgtctggc
     8461 gcgcgacggc ctcccccatg gtggcgccgg tgcccagcag acagacggcg atccccaccg
     8521 cgagcaggac gggcaccgcc atcgccgtcg tccgcgcggg agccgcccgc agcccggcgg
     8581 cggcgatacg tcccacccgc cggtccgcga tccgcaggac ggcgcacacc ggccgggtca
     8641 gcaggggcac gatccacggc gcgaggacgg cgagcgtggg gatgagcacc agggcgaggc
     8701 cgggggcgac ggcagcccgc accgtcgagg ggagttgcgt gaaggccatg acgtacagca
     8761 gcggaacgca cagcatcacg gccatggtca ggccggtcag cagccgcgcc cggctgcggc
     8821 gggaagccag ggccccttcc gtgtccttca ggagcgcgcc gggaccgacg cgcccggcgg
     8881 cgaagacgct ggccatcgcg gccaggacgg ccaccgcccc ggtggcgatg cacacgccca
     8941 aggccgtgcc ccagacctgg cccgtggagg gcagggaggc agcttcgggg aagagctcgc
     9001 ggttcaccag gaggcgtcgc cccgcgtgcg ccaggggcag catgcccagg gctcccacgg
     9061 cggccgcggc gatcgcgagc cgggccacgt cgccggcgac caggcgccgc agccgcccgg
     9121 ccgtgacgcc gagcgcgcgc agtacggcga actgcccgag ccgctgcccc gtccacagcg
     9181 acacggtcga gccgatcacc agcacggcgc acatcagcag aatggacaac agcagcgaga
     9241 gcaggttgcg ggcgtcctgg gcctgggtcg ccgccacgga gcgggcgggg aagtccgcgc
     9301 ggccagcacc gatcaggagc agcgtgcagg cgcccactcc cgccgccgtc atggcacagg
     9361 ccatcgcggc tccggccagg cggccggggt aggcgcgcgc ttcggcgagg aagaggcggc
     9421 gcattcgcat cggtccggcg agggggcgag aggggtggga cgcctcggac actgtcttct
     9481 gccctccaca gtgcgtaagc tggaagcagc gcaggggagg ccacccacat tgtggcctcc
     9541 ccgcgctcat ttacggccgg tgcgaccgtt gatgacatag cgtcagtggc acacgacgac
     9601 gctgacggag ctcagaggag cgtcgaggac agtctcctcg tcgagctcct gcagggcgag
     9661 aacgttcagc attccttgtc acctccttca ggggcgcggt ggggaagggt cggtcccggt
     9721 ctgcgccggg gcggtctttc agtggcagcc gccgaggctg atggtgctga tgggggcgtc
     9781 gacgatcgtc tcctcgtcga gctcctgcag ggccagaatg ttctgcatgt ccgttcacct
     9841 ccttcagggg tgtcgtggga gagggccggt tccggtctgc gccggccgag tgtcagtggc
     9901 acacgacgac gctgaccgag ctcaggggag cgtcgaggac ggtctcctcg tcgagctcct
     9961 gcagggcgag aatgttcagc atggcttctc acctcctctc tcaggcttgt ggggccgggt
    10021 ggtccggagc gtcgctcccg gcgggcggcc acccgcaggt ggggtgggcg ccggggagca
    10081 gacggctgcc ggggttctgg gcggcgacga gcgcgatcac cgcgccggcg gagccggtcg
    10141 ccaggtccgc cgagagacgg accagctggt cgccgtgcag gacgtgagcg tcctcgtacg
    10201 gcgccaagtg cagggaaagg gcgcgcagat ggctgtccag ctctgctcgc caccgccccg
    10261 tacgggccgg ggcgtgggag agcaggtacg ccagcccgga gcggccgttg aacagcccgc
    10321 cctgcaggac gacttccacc gcgccggccc gggcggcgcc ggccacgatg ccgtcggcac
    10381 cgaccgcggc cgcctggggc gggggaagcg cgagggcggc catcgcgacg ccggcggagc
    10441 cttccgccag gtagggcagc agccggctcg aactgtgcat ctgcagcatg ccgtccacgt
    10501 cacgggcgtg caccaggtcg cagcgtacgg cgcgttcggc cgccgccgcc cattgcaggt
    10561 ctccggtcac ttccgcgcag cgggccaaca gcaccgccgg ccccgaccag ccgtacatca
    10621 gccccggccg gtccagcagt cccttgaccc ccacccgttc acgtacccgc agggcgaggg
    10681 cgagtgcttc gtccttcagc ccgacgtcca ggaagaggtg agcgattccg gacagtccgc
    10741 cgaagaggcc cggtgaggcg ggcaggggac cggccaggag gcggtcgacc aggttcgcgc
    10801 cctgcgggtg cccgagccgg tgcaggatcc acgcggcacc tgccagcccg tcgtagagac
    10861 cgggcggcgc atccagggga gcccggagcg cggtattggc cagccattcc acgtcctccc
    10921 cggagaccgt gctcccggcg gcatgccgtg cccacagcac gcccggcgtg ccgtacgcga
    10981 gccccattga ggcgcccgga cggtacccgg ccacgtcgca ggggtagcgc cggtccttac
    11041 ggccggggtc ggcggagcgg gagatgcctt gcagcaacgt ttccgcggtc ggtgcggtcg
    11101 gtgcggtcag cgtcggtggg tcggtgggga tgccgccggg tgctcctgcg ggtgttcctg
    11161 caggcgttcc gggaggtggc aagtgggggc gcagcgtggg cgacagcgcc aggagttcgg
    11221 tcatctgccg gacgaactcc gccggcaggg aggggaagga cgcacgggcc agtccgatca
    11281 gtgaggccac gacgcgaggg ttgcgcaagg tcagcacggt gagggggacg agggcggcga
    11341 gctggcagca gcccagggcg aacaggtccg cctcgcgtgg atcggtcagg gcggggtcgg
    11401 cgaagccggg cgcccccagc gccgcactgc ggaccgagtc gagcggggcg gcgagctcga
    11461 agtccacgag cgccacggtg ccgtcgggcc ggatcaggat gttgcggtgg tggaggtcgc
    11521 cgaaggccac tccggcctcg tgcagcgccc gtacgcatcc cgcgacctgt tccatccgct
    11581 cgacgacgga ggcggcgaag cggctacggg ccgccgcggc gggccggtgg cgggtgagcg
    11641 ggtgctcgcg ccccagccag gcgctgacgg tctccccttc gacgtactcc atggcgaggt
    11701 agtggtgttc ccaggccgtg aaggagccgt accgccgcgg gacgaacggc aggtgcccga
    11761 gtctgccgag gaccgcgtcc tcggtgcgca gtctcgcgac cgcgtccagg ccgttggcgt
    11821 cgaggccggc gtgcggccgg gcctccttga ggacgacttg tccgccgtgg ccgtcggccg
    11881 cgaggtacac gcccccgccg ttggagaagt ggagtgcttt gcggacctcg tagccgccga
    11941 gtgaggccgg cgcgccgtcg gccgccggct gctccgcgag gaagtccggg acgtctgccc
    12001 acggagggac ggtgaagacc gggcggcggg ggtcgggcac gagctgcccc tgcggggtgc
    12061 gcatcgcggg gacccgtgtg ccgtcggcga gttcgcacca catcagcgtg aaggctccgt
    12121 agcggaccga taccgggccg tcgttccagc gccggtcgga cagtacgtag ggcccgggcc
    12181 gtccgcgcat cgccgtctcg agctcctcca aagccgtgcg cagttcgtcc gtggtccggg
    12241 ggtagacggt cacggtcttg ccgcttgcgg cccggtgggc gtacttggtg ttcatcgcgg
    12301 cgacgatctg ccggctgcgc aggaacttcc acggcagccc cagccgccgg cagacgttcc
    12361 aggctgcctc tatcgtctcc tcggcggctc cgggcgtcgc actcacgtgg atcttccagc
    12421 cctgctccgg cagcttcgcg gcgtcaccgg gcgtcaggaa ttgccatacg ccctggtgtt
    12481 cccgccgcca tccctccggg agttcccgca cggagaggga gaccagggaa tccgaatcct
    12541 ggcagcggtc cagcggctcg taccacgtgg aatctgcgat ggtgtacgtc tcgtacctcg
    12601 gatccatggt gccctcccgc cgtgctgcag gcggcatctt cttatgccgt cgtcaatgtc
    12661 tgaaaagggt tactggttac cggagttctg cgaccggtgc gaccggtgcg accggtgtgt
    12721 ggaacgcttt tccgttccgc tacgagaatc ctgcacctgc tcgccaccgc ccggcaatcg
    12781 gcgtaagccc acgcttaacc ggagatctac catccggtaa tgcgtggggc gggcggcccg
    12841 gatccacatc gtcaagcgat atccgtcgaa ttccggagag ttgcaggcat ccggccggac
    12901 aggcgcgcgg tatccgcaac gcacgggtcc gccgagcagc cggggaacgc cgacggccgg
    12961 gagccgagtc atcacagtgc caccgcagcc gcgggcgtcc gtctgtcccg ggcctgcggc
    13021 aacgccgccc cgcgcagcac cggttctgcc gcgtgacgtt ccgtcgcatg cctctcggtc
    13081 ggatgctgct cggccgggtg ctgctcggcc gggtgccgct ccgccgcctc gccccgtagc
    13141 aggaggtggc cgagacgggt gacggtgtgg atcgcatggc tgcggttgcg acgcgtcgag
    13201 accaggccgg cggcccgcag gacggccatg tgctggctca ccgcggccgc ggacacgccc
    13261 agccgttcgg ccagctcggc gttggtgcag ccctcgcgca gcgcgcgcag tgcggccgct
    13321 ctggtccgcc cgaccagggc ggcgaggctg tccggcccgc actgcggacc ggctgcccgt
    13381 ccgccgccca gcagccgcgt gagctcctcc ggccccggac ggtcgggaaa caccaggacg
    13441 ggggcgcggt gcgcgccctg ccgggccggc gggagcacat gccctgcgcg ctgcaggaac
    13501 aaggacgggg ccagcaccag cccgctgccg tccagttccc tctctccgga acgtacgccc
    13561 gcgatctcca aggccggtgc gttccagcgg attcccggac ccagcgagtc cagcagcact
    13621 tccacgccgt cacggcacat gatgtcccgc agggtgtccc ggacctcgcc gagataggcg
    13681 cggatccgcc cccagtgcgg tgcgacggcc atctgctgga agtcctggac cgcggaatgc
    13741 acggacacgg cgggaacccc ggccccgttc gggggaacca tggtgtggcg tcccccgccg
    13801 gtacacaatt ccagcagctt tcccggaccg cccggaaccc ggatcagcgt cgcgacccgc
    13861 tccattctcg gatcgggccg gcggccgccc ccgcacaccc cttgccgcca tgcgcgaaaa
    13921 ccttctccac ggccttcccg gagcgcctcc aaggcgaaca gcgcctccat ggacaggaga
    13981 tccgattcac tgatcctcac gcgtgccagg tcgtcgaccg acaaaatgat gcgatacatg
    14041 aagagcggcc cccgcagcga tcggctccgc ctggatgcgc ggcgacgtcc cggtgccggc
    14101 ggacggagcg ttggccaatg ctgatgtgca tggttcccgg ctcccgggtc gcacggggga
    14161 tggataatcg agtccgtcac ctcagcagac gggcaccgga aaacgacacg gtgacctcct
    14221 gccgctgctt gcgcacccgt cagccgacgt ccggcggtcg atcggccccg cccgcgcgac
    14281 gaacggcgcg gctgccggcc ttccggcgcg gctaccctcc tgctcatgga ggcactggtc
    14341 gtacggctgt cgcagttgga tgcggaagca gggggcgcca tccgcgtcgt catgttctac
    14401 gacacgctga tgcgccgccg ggtggacctt ccggcgctcg cccgggcctc ggcgggcctc
    14461 gccgagtgcg tggcggggat ccggctcttc ggcacggggc gcacgggcag ggggtcactg
    14521 cgtacgggcc taccgggcag ggggccacta cgcacgggtc caccacccac ggccccaccg
    14581 cgcgcgggtt cacgacggtg ccgatcacac tggacgagga agagatcggt gccgtgtggc
    14641 tggaacgtcc cggcccgccc ggcccgcccg gcccgcccgg cccgttcgac gacctgctgc
    14701 tggaccggct cgccatcgcc gtcgccgcgg tcgtcgagcg acacggaccg gccttcacca
    14761 ccatggccga ccccgccctg gtggaactcg tgatcagtcc cggcagcgac gaggccgcca
    14821 gagcccgggc gctgcggctc atggggttct ccgccggtct gccggtccgc gtcgccgccg
    14881 tgcggtcgga gatccccctc gaccacgtgg gcggatcgat ctgcgcgacc cgcccggtga
    14941 aggcggcgaa gtcgccggag taggcgtcat cctggcctcg gcgatcgccg cggaccggct
    15001 cccggcaggc gtacgcgcgg gcatcggcac cgccggctgc ccggcccggt cgtggcggca
    15061 ggcccgcacc gccctccgct tcaccagccc gcgcgaacca gccgtgcact acgacggact
    15121 cggcgccctc gccctgctcg ccgagatacc ccaggacctc tcccgggaca acgccgacgt
    15181 ggccgcgatc gcccgcatgg ccggcagccc ggacgacctg gagaccctcg acgcctactg
    15241 caccaccgga tccctgcgcc gggcggccga cctcctgcac ctgcaccaca gcagcgtcgc
    15301 ccgccgcctc gaccacatcg ggacgaccct gggcatcgga ctcaccgagc ccgccggcct
    15361 ggtccgcgcc agactcgccc tcaccgcatg gcggctgcac ggcgactgac acctcgctcc
    15421 ccacgcgccc gtgagctgcg ccttccgtcg gcagggcagg gctcgctgac ggagtgtcgg
    15481 aactgccacc cgtgcgtgca ggtgtgaaac cggcgtggtg caggatgact tctcgcgccg
    15541 ggtcactgcc gtggcccggc gcgagcacga tccgtcggga cagacaggta caaggtgacg
    15601 aatcattact ccgggcttcc ggcgacggcg cgcgacgccg ccgcttcctc ctccgcaggg
    15661 cggggaggac gccggtgaac cgggatctga cactgcatga catcatcgtc gccggcatcg
    15721 ccgtcgccgc gggcctggcc gtcgccctcg tgctgcgagt ggttctgcgc tggctcggcg
    15781 tgcgcgccct cagaacccgc tggcagggcg acgacatcat cgtcgacgtg ctgcgcacgc
    15841 tcgcacccgg atgcgcggtc gcgggcggcg tggcggcggc cgccggagcc ctcccgctca
    15901 cccgccaggt cggccacgtc gtcgacgagg tgctgatggg cgccgtcgtc ctcatcgcga
    15961 cgttcaccgc cgcccgggtg atcagcggac tggtgcgctc catggcgcag tcccgatcgg
    16021 gcgtggccgg atcggccacg atattcgtga acatcacgcg catcgcggtc ctggcgctgg
    16081 gcttcctcgt catgctggaa accctcggca tatccatcgc cccgctgctc accgccctcg
    16141 gcgtcggcgg cctggcgatc gccctggccc tgaaggacac cttggccaac ctcttcgcgg
    16201 gcgtgcacat cctcgtctcg aagacggtcc agccgggcga ctacatacgg ctcagcagcg
    16261 gtgaagaggg ctacgtccgc gacatcaact ggcgcatcac ggtggtcgag cagctcaaca
    16321 acaacctggt catcatcccg aacgccaagc tcgccggcac gaacatgacc aacttcagca
    16381 ggccggaaca gaagctggcc gtcacggtgc aggtgggcgt cggctacgaa agcgacctgg
    16441 agcgcgtcga gcggatcacc gtcgaggtcg ccgagagcgt gatgaaggac gtcgacggcg
    16501 ccgaccccga ctacgagtcc gccgtgcggt tccacacgtt cggggactcc cggatcggct
    16561 tcaccgtgat cctcggagtc ggcgagttca gcgacaagta ccggatcaag cacgaattca
    16621 tcaagcgcct gcaccagcgc taccgcgccg agggcatccg catccccgcc ccggcacgga
    16681 ccgtctccct gcagcaggcc gaggggacga ccacggagac cacgatcccg cacccccgcg
    16741 cgtccctcga ccaggcttcc tgagcaccct ggagcccccc ggaatccgct gacgctgtgc
    16801 gtattcgtgc ttgctttgtg ttgtttcggg ggtggtggcg tgtgaggccg cgcatgaggc
    16861 ctggatcact tacgaaatgt gttagtaaga agtgcggcgg aatccggggg cggtgccgct
    16921 atttccgtgc cgggcaatga acggtcgtag taggtcacag cccttgtcag gggttttcgt
    16981 cgccgctaac aattacgggg tcgctgggcg ccgtcgaccg agaaacggcg cttgatttct
    17041 gcgccgcttc agggccgggc gacatccgcg attggaaggt tcagctcact catgcgctcc
    17101 accgtctccg cttatgcccg tctgccgaag attcacaagt tctccgttgc cggtattgcc
    17161 gcgaccggtg ccgctgtcgt cgcggtggcc gtcgctccgc acgctttcgc cgctgatgcg
    17221 gctccggctg ctgcggtgaa gccggtggcg tggagtgccg aggctttcgg tgagacgcag
    17281 caggccgagc tggacaagca cgtcgatgct gccgccaagg ccggcgcgga ggctgctgcg
    17341 gtgaagccgg tggcgtggag tgccgaggct ttcggtgaga cgcagcaggc cgagctggac
    17401 aagcacgtcg atgctgcggc catccgccgc cgctgatgcc gctccggctg cagcggcgaa
    17461 agcgtgcggg gcgacggcca ccgcgacgac agcggcaccg gtcgcggcaa taccggcaac
    17521 ggagaacttg tgaatcttcg gcagacgcct tcttcgccgg agcagcgggc ttcgccgggg
    17581 cagccggctt ggcggcgatg gggggggggc ccccccccct cgccgagcgc ctggcctcct
    17641 ggaacgaacg cgaaccacag cgcctgatcc agccctcaag attctcggca tacgccttct
    17701 gcgccggatg gcgaccattg cgacgtcgtc gtcgagggcc ccgccggcgt gggccagcag
    17761 gtcctggcgg atgcgctgga tcagtgagtc cctggacatt ctgcgggcga agggcattcc
    17821 ggcttcgtac gacggcatca agcgcaacat catgcgtgag tcgaccggta acccgcgtgc
    17881 gatcaatgac tgggacatca atgccgtgaa tggcgttccg tcgaagggtc tgctgcagat
    17941 gatcgatccg acgttcacgg cattgatgtc ccagtcattg atcgcacgcg ggttaccggt
    18001 cgactcacgc atgatgttgc gcttgatgcc gtcgtacgaa gccggaatgc ccttcgcccg
    18061 cagaatgtcc aggggctcgc tgctccggcg aagcccgctg ctctggcgaa gaaggcgtct
    18121 gccgaagatt cacaagttct ccgttgccgg tattgccgcg accggtgccg ctgtcgtcgc
    18181 ggttgccgca ccgccgaggg cggtggcacc ccgtaccaac ggggacgcca ccgccctcgg
    18241 cggagggcgg gggcgtcccc gttggtacgg ggtgcccccg ccctcgccgc atacccgggt
    18301 ccggggcggt cacacagggc tgcgccggat ggcgaccatt gcgacgtcgt cgtcgagggc
    18361 cccgccggcg tgggccagca ggtcctggcg gatgcgctgg atcaggcgct gtggttcgcg
    18421 ttcgttccag gaggccaggc gctcggcgag ggggtagaag gtgccgtggg ggtcgcgggc
    18481 ctcgatgacc ccgtcggtgt agagcaggag gaggtcgccg tcgcggaagg cgaaggcctc
    18541 gggttcgtag tcggcctccg tcgtgggggt gcccaggccg aagggcaggt cggggtcgga
    18601 gaccgccagg gtgacgacct cgccgtcgcg gacgatcagc ggcggcggat ggccgcagct
    18661 gatgaggtgg agcaggggcc ggtcgtcggg gatctccagc acggccgcgg tcacgaagct
    18721 ctcgcccgcc gcgagctcgt cggcgggctc ctccgcgtcc cagtagaccg tgttgtgcag
    18781 gtgggcgacg aggcggggga ggggcgggaa gcggtgggcg gcggcgcgga aggcgccgag
    18841 gagcagggcg gcgtccccga cggcgggcag tcccttgccg cggcagtctc cgatcatgac
    18901 gcgggtcgcg tcgcgggcac gcacggccgc gtagaggtct ccgccgatct gcgcctcggc
    18961 ctcggccgcc gcgtactccg aggccagctc cagggggccg atgcgtgagg gaaggggcct
    19021 gagcaggact ttctgcgcgg cgtcggcgat tccccaggcc cggtccagcg cctgttcgtg
    19081 gcgctcgcgc agggcgtgga aggcgacgat gaagcagacg gccaggaaca gggccccggt
    19141 ctgcgtctgg tggtcggcgg tcgtggcccg gccgaagatg aacccgaggg cgatctgggc
    19201 gcccacggcc aaggcgccga tgaaggcggt cagtcgcttg ccgccgaagg tcgcggtgag
    19261 tgcgggggcg gctaccagca gggggccgag gtggatgtcg gggccggtca ccaggtcgac
    19321 cgccatgatg acggcgatga gcaccaccgg ggcggcaatc agcgcgcgcc ggggtcccgc
    19381 ggggtcgggt cctgccggaa ggaactgaat gcgcatgtcc cttgcttacc tccccacccc
    19441 ctccgtgcag ctcctgcgac acgggccgga tgcgcagagg ccgaccgggc gccgacggga
    19501 ccggctccgg gaccgcgtcc cggtgatcat gtatctcatg gggagaacgc cgctggtgcc
    19561 cgtccggcca cgtcggcgac ctgatcttct ggccgccggg actcgtcgag ctctcggccg
    19621 aggaagtggt cgaccgtgcc ctggagtacc ggcccatcac cctgtgagac cgggctgcgg
    19681 agcccggcac ccctggtggg gccgcttccg cagcgcagcc gggcccggcc agggaccggc
    19741 tgcgctgcgg gcgggtggga tcagtggttc gtgccggagt cccagatcgc ctggctgccg
    19801 tcgtagatga cgacgttgcc gtcgtcctgc acgaccaggc gcgagcccgg gtgcccggcc
    19861 gtccgggacg accagacggc cttgcccgag cgggtgtaca ccacgaagtt gccgtcttct
    19921 tggaaggccg ctctccaccc ctggccgacg gttctggagg cccagcgggc tctgccgaac
    19981 tcgtcgtaga tgacgaggtt gccgtcggac tgcatgacca gattggcggt gtcggaggtc
    20041 agggactggt tctgttccag ggtgaacggg gcgtggacgg tgcgggtggc ctggacaccc
    20101 ggctcggccg ctgcactcgc agcggccggg gcggcgtggc ccgaggtctc cgcggcgccc
    20161 gcctgcccgg cgagggcgac gacggagagt gcggcggctg ccagcagtgt ggtggtcctc
    20221 ttgctcacga aagatccttt cgtcgagtgg tgcgtccacc ggccccggat gagggacctg
    20281 ggtgggggga ctgcaccgga ctttttcacc acccgtgtgc cggatgccgc tgttcgcctc
    20341 gcgatgacgc attcgcttca gtgtttggcc ggagcctcag ccgtgacgaa ggctcccgcc
    20401 tgtgcggctg agatcgcagc cgcggccgca cggtccgccg ccgcctcgtc gagcgcctcg
    20461 cccgtggtca gcaggcggta gtagaggggg gcggagacgg cccggacgac ctcgcgggtg
    20521 tcggtcccct cgggcagctc gccccgctcg acggcttccc ggacgcaggg ctcccactcc
    20581 gtgacgcggg tggcgtagaa gaggcgcagg gccgaggccg cttcgtcgtt gcaggtcgcg
    20641 gcggcgatca ccgccttgaa gagcgctccc tggcgcgggt cggccagcgt gcgctgcacg
    20701 aggcgggcat tggtgcgcag gtcgccctgg agggtgccgg tgcgggcacg cgggagggac
    20761 tgctcggcca tgtccgcgag gaggtcggcc accagggcgg ccggcgttcc ccagcggcgg
    20821 tacacggtcg tcctgccgac gtccgcgcgc cgcgccacgt cggcgagatc gaggccggac
    20881 agcccgccct cggccagggc gtctccggcc gcctgcagga cggcggctcg cacgcgggcg
    20941 gtgcgcccgc ccgggcgcac ggttcccgga tccgcactcc tggattccat aacgggactc
    21001 ctattccatt aggggttcgg cctctgctac ggtgggcaca tcttaacggg acttcggtcc
    21061 cggtagtgct gtcgacccga acccgcacgg cgcagggcgg cacgagggga tacaagggga
    21121 agggaaccgc tgtggaattc cgacgactgg gcgcttcagg actgatggtt ccggcgctga
    21181 gcatgggcgc gggcacgttc ggcgggcgcg gagagctctt cggcgcctgg ggcgacaccg
    21241 acgccgagga agcacgccgc ctcatcgaca tctgcctcga ggcaggtctc aacatgttcg
    21301 acaccgccga cgtctactcc gccggcgctt cggaagaggt gctcggcgcc gcgatcaagg
    21361 gccgccgcga cgaggtcatc atctccacca aggcggggct gccgatgggc gacggcccgg
    21421 cggacgcggg aacctcgcgc tcacgcctca tcaaggccgt cgaggacgcc ctgcgccgcc
    21481 tcggcaccga ctacatcgac ctcttccagc tccacgcctt cgacgcgggc acccccgtgg
    21541 aggaagtcct ctccacgctc gacgacctcg tacgggccgg gaagatccgc tacaccggcg
    21601 tctccaactt cgccggctgg cagctgatga agtccctcgg caccgccgac aagcacggct
    21661 accagcgcta cgccgcgcac caggtctact actccctcat aggccgcgac tacgagtggg
    21721 agctcatgcc gctcggcctc gaccagggcg tcggcgccgt cgtctggagc cccctgggct
    21781 ggggacgcct caccggcaag atccgccggg acaagccgct gccggccggc agccgtctgc
    21841 acgccaccgc ggactacggc cctcccgtgg acgacgaact cctgttccgc gtggtcgaca
    21901 ccctcgacga gatcgccctc gaaaccggga agaccgtgcc gcagatcgcc ctcaactggc
    21961 tgttgcagcg cccgacggtc tcctccgtca tcatcggcgc ccgcaacgag gcgcagctgc
    22021 ggcagaacct cggcgcggtg ggatggaacc tgaccgccga tcaggtggca aggctcgacg
    22081 ccgcgagcgc cacgaccgcg ccgtacccgt acttccccta cgagcgccag gagggcttcg
    22141 cccgcctcaa cccgcacccg gtccggcgcg gagcgggcgc cgccggcgag gcgtaggcag
    22201 caggaacgcg cgggacgggc cgcccgcggc aggtcaccgt cggctgcgcg gcccgcgagc
    22261 cgggcagccg acggtgacct gccgcaccgt gcggcggcga cgcgacgcga cgcgacgcgc
    22321 gtcaggcggg cagggccgct tcgatggccg agacgacctc ggcggcgtcg ggctcggtct
    22381 gcgggctgaa gcgggcggcg acgctgccgt cctgggcgat gaggaacttc tcgaagttcc
    22441 agcggatgtc gccggtgtga ccctcggcgt ccgccgtgcc cacgagggcg gcgtacaggg
    22501 ggtgccgccg ctcgccgttg acgtcggtct tctccgtcat cgggaaggtc acgccgtagg
    22561 tggccgagca gaaggaggcg atctcctcgg cggatccggg ctcctgg
//
