LOCUS       NZ_LNBE01000003        21230 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_3, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000003
VERSION     NZ_LNBE01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2630732)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 2630732)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1332584
            Orig. end                         :: 1353814
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="10"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21230
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11230](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11230
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     misc_feature    complement(100..113)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    complement(958..969)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     misc_feature    962..975
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.71"
                     /tool="antismash"
     misc_feature    complement(963..976)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    963..977
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.63"
                     /tool="antismash"
     misc_feature    complement(964..977)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    complement(965..978)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.8"
                     /tool="antismash"
     misc_feature    complement(986..999)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            1092..1691
                     /locus_tag="AS857_RS11615"
     CDS             1092..1691
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241368.1"
                     /locus_tag="AS857_RS11615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_058043034.1"
                     /transl_table=11
                     /translation="MSPKQQRGEATADLLLTTALRVYAEAGRQGFTVNAVTAASGVSLG
                     SLYHHFGSFDGLAAALYTRCMEQLLDEIVGAVKRSRTARTGVRALVLAYLRFTEEHRDA
                     ALFIHASAYSGYLAAHAEEIRAAKAAKLSGLGEWLRPRMEAGEIITMPPALIEVLVMGP
                     VAEAARRWLASTYDDIDLAEAARILPDSIWRSLRPT"
     gene            complement(1763..3352)
                     /locus_tag="AS857_RS11620"
     CDS             complement(1763..3352)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (116-486). E-value: 2e-15.
                     Score: 49.0. Matches aSDomain:
                     nrpspksdomains_AS857_RS11620_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735349.1"
                     /locus_tag="AS857_RS11620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_058043035.1"
                     /sec_met_domain="PF00561 (E-value: 2e-22, bitscore: 77.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLSPVAARRASAAGLALTACLTAAPAAFASARTAPVAQPSAAP
                     PEAGLDRYYQQRLDWRSCIKGPDDTTGRDLDKAGAQCADVTVPLDYADPRGRTITVAIS
                     RLKATDTRHRVGPLLINFGGPGGPALGDPPDMRKAMKDVGARYDIIGMDPRAVGRSTPL
                     DCHWPVGHSIYSAGLGREGFDRQVALHKDLAAKCRATNASMLPHINTRNTARDMDVIRG
                     ALGERKISYLGYSYGTYLGTVYTQLFPGRYDRMVLDGAIDPRRYNPRLLRGVEKENEQA
                     LADWATWAAKKHDAYGLGRTRAQVLSTVDRIVKASARGLTLGTAPDSFPLDDTQVPTLL
                     FGGLSSDSDSARAELGDLVSTLAKAADNQSAPLSPELKKTLQEMLTDKNSQYGSAQTAI
                     LCGDGAAPRDPETYWRDIERSRAAHPLFGPLTNNIGPCAFWDRPREEPTRVQHDAPALI
                     VAATGDTRTDYEGGRALHGMLPGSKLITLKGANQHGVYLEYGNACVDRQVNAYLATGEL
                     PAGDRTCLKTNG"
     aSDomain        complement(1895..3004)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS11620_Abhydrolase_1.1"
                     /evalue="2.00E-15"
                     /label="AS857_RS11620_Abhydrolase_1.1"
                     /locus_tag="AS857_RS11620"
                     /protein_end="486"
                     /protein_start="116"
                     /score="49.0"
                     /tool="antismash"
                     /translation="PLLINFGGPGGPALGDPPDMRKAMKDVGARYDIIGMDPRAVGRST
                     PLDCHWPVGHSIYSAGLGREGFDRQVALHKDLAAKCRATNASMLPHINTRNTARDMDVI
                     RGALGERKISYLGYSYGTYLGTVYTQLFPGRYDRMVLDGAIDPRRYNPRLLRGVEKENE
                     QALADWATWAAKKHDAYGLGRTRAQVLSTVDRIVKASARGLTLGTAPDSFPLDDTQVPT
                     LLFGGLSSDSDSARAELGDLVSTLAKAADNQSAPLSPELKKTLQEMLTDKNSQYGSAQT
                     AILCGDGAAPRDPETYWRDIERSRAAHPLFGPLTNNIGPCAFWDRPREEPTRVQHDAPA
                     LIVAATGDTRTDYEGGRALHGMLPGSKLIT"
     gene            complement(3349..4527)
                     /locus_tag="AS857_RS11625"
     CDS             complement(3349..4527)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377929.1"
                     /locus_tag="AS857_RS11625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_173864769.1"
                     /transl_table=11
                     /translation="MAASLDTLTHRHGIPGAAVEVDDGRCGKWNVARGVADLGSGRPMN
                     AQDRLRIGSISKTFTATVVVQLAAEGRIGLDAPVERYLPGLIRGNGHDGRRITVRRLLQ
                     HTSGLPDHSEAIVDRPVEQWRYRHFEPRELIATALELPRPDKKWHYSTTNTLIAGLIVE
                     KVTGRGVEAEVTRRILEPLGLRDTYWPGDETRIRGPHSRSYFTGPGAPDGTPSPRIDGT
                     EWNVTFGGAGGALISTPSDVNRFYGALFGGKLLPARWLDEMKRTVPADPDRLWPGARYG
                     LGLIASPLECGGWWWGHGGTVPGGHRALGAVGPGGRSVALVLNQVPGTDRAEEDFRAVV
                     NTAFCADRSNPSGSVSSSRYAGTTGSVSPSGSAHTTSSVNTTGPTSHIKETP"
     gene            complement(4756..6306)
                     /locus_tag="AS857_RS11630"
     CDS             complement(4756..6306)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938212.1"
                     /locus_tag="AS857_RS11630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carboxylesterase family protein"
                     /protein_id="WP_058043036.1"
                     /transl_table=11
                     /translation="MPEQPSVRTTDGLLEGRWRQGHAVFRGVPYARPPVGALRFAAPAP
                     PLPWEGTRQAAEFGPAAPQSGPVRANPGGGTDWLTLNVSTPDPGAAGLPVLVWIHGGAY
                     VAGASSDPLYDPAALTGAGLVVVSINYRIGAEGFALLEGAPPNRGFLDQIAALQWVQRN
                     IASFGGDPGRVTVAGQSAGAGSVAALLTMKPARGLFLRAVAHSVPGNYCTRALAGEVAA
                     ALADRLGTAPTAAALAEIEPGLLADELTSLSAGLPGLRARWGRLARTGVAMGPVVDGEV
                     LPETPWPALTGGRASATELLVGHTRDEFRLFSIMSGRHGTFTDEDARTALDLFAPAPDG
                     ADAYRAALPRATAQELLESVYSDALFRMPSLQLAEANAAAGGTSFLFELQLSSPAFGGA
                     LGACHSLDVPLAFGTPDSPAGRGLLGDGSTPGAVAVSRELQQAWVRFVTTGDAGWPAYL
                     PGQRLTRVLDAESKTVPYPEEASRRIWEGRAPAPFDLAQPAGSPWWSRPPTEYGGQPE"
     misc_feature    6351..6369
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            complement(6820..8688)
                     /locus_tag="AS857_RS11635"
     CDS             complement(6820..8688)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982328.1"
                     /locus_tag="AS857_RS11635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1380 domain-containing protein"
                     /protein_id="WP_245699785.1"
                     /transl_table=11
                     /translation="MSPQEERAALTPRTSLYAYALRLRDAEPDDRPPRRGYRLPDPDTA
                     PDTAPASPSAAPAATPQPGNLGWAEARAAATDAIAPLLSDPDTLRAADEVHRRLRALGT
                     RVSPLRDALAELPLKDEAAARALGRRLVRTGTSAPAVSVGLGLLARLGEPEDIPCLTVL
                     GLFRTFTRPVVAALTAIDCPTGALVWLSRYTEGRELRHLVDALLARDDRAARDGLLTVP
                     LDPRAVGSETARRIAEAVMLDDIIGDDPVDAPTLAQAGRLLVRMARADDYQYEVLAYDR
                     AVAAYEAFVTRASRLPPGLDHYAILLSVALDLHSGPSVLLDWRTGQREALLETLESVLT
                     SPAWTAVPAGEPTDPGERRRLHWMRRAARQPFTRPAAPGRLRVEVVVRDPAVPESVETR
                     LLIDGRPLVPEAFGRGPAHSPEYLLDTGRLRAAAEPREVQLAEAYCTEGCCGALHVTIC
                     RDGDQVVWRDWRRPHTLPTRQPAPELPEYRFDAAAYDAEIARAETDRSWAWPARNAARL
                     IAAGLRDRPGILARWDARLDWAGTDFGEPDTIAVSFTFRPGTAAGRQDKDGHYLQFIWD
                     LQDDGTPPEEQAAAALHRLSTEDPKGYAEVRGGSRESAEALGYPWP"
     gene            8855..9349
                     /locus_tag="AS857_RS11640"
     CDS             8855..9349
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009070695.1"
                     /locus_tag="AS857_RS11640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="macro domain-containing protein"
                     /protein_id="WP_058043037.1"
                     /transl_table=11
                     /translation="MASEIVYEHGDATAPRGSGPRIIAHVCNDSGGWGKGFVLALSRRW
                     SAPEAAFRRWYRDRQRNDFGLGAVQYVEVEPGLWVANMVGQHGICTAAERAAGVGVPVR
                     YEAIDTALASLGDKALALGASVHMPRIGCGLAGGRWDTVEPLVTRRLTGRGVPVTVYDP
                     A"
     gene            complement(9334..9648)
                     /locus_tag="AS857_RS11645"
     CDS             complement(9334..9648)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS11645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_144440781.1"
                     /transl_table=11
                     /translation="MNAATATGLLHLIAAEPTLLASAPADPDESDLHLRVREGRHLCLG
                     CGQPARCAAVVNSDTHGPRWLDLCSPCWQTVRTANVLCGDAEGAGEPGEPGDADGQAGS
                     "
     misc_feature    complement(9867..9881)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.74"
                     /tool="antismash"
     gene            10001..11230
                     /locus_tag="AS857_RS11650"
     CDS             10001..11230
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034415.1"
                     /locus_tag="AS857_RS11650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_058043039.1"
                     /sec_met_domain="salQ (E-value: 1.4e-145, bitscore: 481.9,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 5.8e-62, bitscore:
                     206.3, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFASRSQTWQVRSQQTIAYEIVETRGLLDPRNDGLLAVPGGGRA
                     AGTRLVVLDHSIDALYGTRIRDYFAHHGAEVEYLTIQGAEENKNIEQVMQVADKLNEVG
                     THRLSSPPLVIGGGVVADVVGLAASLYRRGIPYVRVPTTLLAQVDVSVAAKTGINYGGY
                     RNRLGSYSPPPRTLIDREFLATVPERELRNGMGEIFKMALIKDRRLFELLETYGAALIS
                     ARFQDPAAGDDGVEGVAGEIADEVIGRAIAGMAEELEPNLWEKNLERSVDYGHSFSPLV
                     EMRAIPELLHGEAVAMDCVFSAVIAANRELIPAADLQRVVAAARRLGLAPSHPLFCDTD
                     LVLEALEDTVRHRDGRQNLPMLTGIGQVRFLNDVTEVEIKQACEAMADLLDAVPASSTS
                     PASPAAEGRR"
     misc_feature    10109..10111
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11227..11976
                     /locus_tag="AS857_RS11655"
     CDS             11227..11976
                     /NRPS_PKS="Domain: PKS_KR (5-120). E-value: 4.1e-15. Score:
                     48.1. Matches aSDomain:
                     nrpspksdomains_AS857_RS11655_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="AS857_RS11655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_058043040.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-35, bitscore:
                     120.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2e-34, bitscore:
                     116.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDRVVLVTGASAGIGRESAAAFAEAGMTVVLAARNEERGHRAA
                     EEIRAGGGDAQFFRCDITEPDDVRALFARITATYGRLDHAFNNAGVPGDGRLVDVSEED
                     FDRAFSVNTRGLWLCLREELRLMAEQGHGSIVNNTSVHGLRTVFPGIGAYVASKHAAVA
                     LTRVAALEHARDGVRVNALAPGPIETEMLAASEAAVGGATTWRGLIPSGEIGTPRQVAD
                     VAMWLFSPASSYVNGQTIGVDGGFLAV"
     CDS_motif       11242..11334
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AS857_RS11655_0001"
                     /evalue="3.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AS857_RS11655"
                     /protein_end="36"
                     /protein_start="5"
                     /score="13.4"
                     /tool="antismash"
                     /translation="VVLVTGASAGIGRESAAAFAEAGMTVVLAAR"
     aSDomain        11242..11586
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS11655_PKS_KR.1"
                     /evalue="4.10E-15"
                     /label="AS857_RS11655_PKS_KR.1"
                     /locus_tag="AS857_RS11655"
                     /protein_end="120"
                     /protein_start="5"
                     /score="48.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVLVTGASAGIGRESAAAFAEAGMTVVLAARNEERGHRAAEEIRA
                     GGGDAQFFRCDITEPDDVRALFARITATYGRLDHAFNNAGVPGDGRLVDVSEEDFDRAF
                     SVNTRGLWLCL"
     gene            12063..13634
                     /locus_tag="AS857_RS11660"
     CDS             12063..13634
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742206.1"
                     /locus_tag="AS857_RS11660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GMC family oxidoreductase N-terminal
                     domain-containing protein"
                     /protein_id="WP_058043041.1"
                     /transl_table=11
                     /translation="MKTDGVHGAGGTYDVIVVGAGAAGSIVAARLSEQRDRSVLLLEAG
                     PADDDPAIARPASWPFLLGGELDWKYRTVPQDALAGRRLAWPRGRVVGGSGAINAMVHV
                     RGAASDFDAWARWGGAMWDAQHVMPYLEALEGPAGAPQYGRIPVAENTAPHPFAAAFVA
                     AAEKYGLPSNLDFNSGVQEGVGLYRTTRTDDAEPGPGRTTPATPARRGNTAHTHLRPAL
                     DRPNLTLLTGATVTAVEVEDGRAAGVRILRDGRVTTVRCAGEVILCGGAVASPQLLLLS
                     GIGPAAALAALDIPVVTDLPGVGANLHDHVQVSLAYDTTEGRPVADFSNLGEAGGFVTL
                     YPGSPAPDVQLSFAPMKDLNNGSELGRGFTVGPGVTRPRSRGSLTLASADPTAHPLIDP
                     RYLSDPHDLDTLVEGVRIARDIAATAPLSDFAAGGPLSPAATRRELEDFVRANAQTQFH
                     PVGTCRFGQEADGMAVVGPRLDVRGVAGLRVADASVIPNMITGNIHAAVAAVAERAAEF
                     VQEDLA"
     gene            13631..14686
                     /locus_tag="AS857_RS11665"
     CDS             13631..14686
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742205.1"
                     /locus_tag="AS857_RS11665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_058043042.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 8.9e-23, bitscore:
                     78.4, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 7.2e-26,
                     bitscore: 87.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPAPTPAPAPLRWGVLGATSYIATHLMPAVAGTPGCELTAVASR
                     PGRTEQAATAGEPFGAAAHRDYASLLADPAVDAVYIALPNTDHVEWTVRALEAGKHVLV
                     EKPMAMDEKGCARIEAAAEASSRTVMEAFMYRFHPQQARAAELLASGAVGELRVVRASF
                     AFAIETGSGNIRLDPALGGGATWDVGCYAIDVPLFFFGQAPERVSARFGRRPGLEVDTS
                     AVATMDFGRGRSAVVDYSIDYGPRAWYELQGTHGTITVRNAWAMSGEDGVITVLTADGV
                     REETVPAANHYQLQVAHFAEVVRAGGGAGSGVRVPLADSRRTARVGESLVASAAADGAP
                     VPCGDEGPAPQ"
     gene            14683..16089
                     /locus_tag="AS857_RS11670"
     CDS             14683..16089
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00879.1"
                     /locus_tag="AS857_RS11670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_058043043.1"
                     /transl_table=11
                     /translation="MTQTHVRSSPLRAFTVLLTSLGGLLFGYGTGVIAGALPLVSRTYD
                     LSSWAQGAAVSAALLGAALTAPTSGRLADRLGRRPVLGGATAFYAAGTLLSATAEGPAS
                     LLVGRLLVGLALGATSFAVPLYISEIVPPARRGALVTVNQLMITVGLLLSYVVAYVLES
                     SGNWRAMFALGAAPALILLAGLPFVPESPEWLHSRGQADRAAREAHRLGLPVRAADDAP
                     SAARGFGLRAAAAHAGPRWVALGLAIAVLVHLTGLNTAIYYAPTILADSGLTSSGGVAG
                     SVLVGSCNVVATVFTIVFLDRWGRRPLMLGGLAVMAAAAVAIASVQSLGDPGVATAVLL
                     CLFITAGAVGPAAVFWVYIAEIYPARARGALMSLATAAHWGADFVVATTFLPLVQGLSL
                     EGAFLVYAVITAASAVGLGKWMQETKSAPAATAEIATVSVPPAPVATAPTVPIVPTVPA
                     RSDHPLETER"
     gene            16098..16694
                     /locus_tag="AS857_RS11675"
     CDS             16098..16694
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742203.1"
                     /locus_tag="AS857_RS11675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family phosphatase"
                     /protein_id="WP_058044081.1"
                     /sec_met_domain="HAD_2 (E-value: 7.8e-28, bitscore: 94.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPDLAPRNAACLLFDWDGTLVDSQYTNYRAMAAALQQEGVDLAQ
                     DWFDARTGLSSAEMIRALLDERGLGLGRPLEEVVAARDALFLEEAHTVRPHAAVLAVVE
                     AMKHRLPMAVASGGARHIIETTLKHQPFHDAFQALVTRDDVERGKPAPDIFLAAAEALG
                     AHPSRCLVYEDSDEGIAAAHAAGMPVIDVRPFTRR"
     gene            complement(16681..19107)
                     /locus_tag="AS857_RS11680"
     CDS             complement(16681..19107)
                     /GO_function="GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605523.1"
                     /locus_tag="AS857_RS11680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Orn/Lys/Arg decarboxylase N-terminal
                     domain-containing protein"
                     /protein_id="WP_058043044.1"
                     /transl_table=11
                     /translation="MTDGTVLFAVRENSGDGGTGAEQLRRIHNELEAAGYEVRWASTSD
                     DARAVLRTEAGLAAAVVDWGLPGTDGEGGKADGKTDAKEGGKEDGTEGGDPGGAGVLRQ
                     VGRRFRNLPVFLITAGEDLDHLPLWVAETVVGYIWPLEDTAPFIAGRIARAARGYQEDL
                     LPPFFKALRQFDDTHEYSWHTPAHSGGVAFLKSPVGRAFYDHFGERLLRSDLSISVEEL
                     GSLFEHTGPVGAAERNAARIFGADRTYFVLHGDSTCDRMVGHFSVTRDEIALVDRNCHK
                     SVLHGLVLSGARPVYLVPTRNGYGLAGPLPPAEVQAQSVASRIARNPLTQGAVSPDAQY
                     AVLTNSTYDGLCYDALQVARALAPSTPRLHFDEAWFAYARFHPLYAGRYGMAVGPDTFP
                     GAERPTVFSTQSTHKLLAALSQSAMVHVKPAPRAPVEHERFNEAFMMHGTTSPLYPMIA
                     SLDVAAAMMDGPQGRWLIDEAVAEAVRFRQTVVRIGRRIAAAGDRPGWFFGVWQPEAVT
                     DPATGEQVSFADAPAELLRTEPSCWQLEPGADWHGFPGLTEGYCLLDPVKVTLTCPGID
                     ASGRMSDWGIPARVLTAYLATRNIVVEKTDSYTTLILFSMGITKGKWGTLMDALMDFKT
                     LYDEDAPLERVLPELVEAHPQRYTGGTLRGLCQEMHDHLRETDLVELLDTAFQDLPEPV
                     TPPQHCYQRLIRGGTERVRLAEAAGRVAAAMVTVTPPGIPVLMPGENTGTQDGPLLCYL
                     KALESFDRRFPGFHSEAHGVTLDPDSGDYLIECVRRIPAQQAGQTAASSVQVNDV"
     misc_feature    19071..19088
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(19148..19166)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.46"
                     /tool="antismash"
     gene            complement(19289..20209)
                     /locus_tag="AS857_RS11685"
     CDS             complement(19289..20209)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS11685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_058043045.1"
                     /transl_table=11
                     /translation="MAFLLGTAWLAGALVVPWAWKVGVVWAWAGGLPGAVGALVAGSAV
                     MVAALFAAGLPVRDMRAGPAAPPVRRTTSGQVGWAVAVFLGGSAGVALGYLARQSGDIG
                     LGGDSTLFLWCGVPYALCAALSVPARAVRATAGTVMATTAVLLVWSGYEADRSKELASL
                     LEGSPLPREHLLLPEAPDGYEIDAGNGSISAGGLRLGYRHTGSGKNPQRQPFQYEVSPG
                     STSPCADHTLPGPATCKDLGGGFTSVTRKLGDGSTADGLSLQRDGVTLTVTVYEPVPGP
                     ELRRMLERAHRADDGELLRALHFEP"
     gene            20391..20666
                     /locus_tag="AS857_RS11690"
     CDS             20391..20666
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS11690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_058043046.1"
                     /transl_table=11
                     /translation="MEGAILALAGSDLLARLVSRIEHPGVLGLSLLALAGTFFGGPFPE
                     TGNWPRVEVHCALVGAGPVVLGRLMRSRREIAEQFGNRHGPDPAVS"
ORIGIN
        1 gggcggtccc ggggatcgct gaccgtgctg ttccagacga gcctgatcct cgggccggca
       61 ctggcctccc tgctcgtcgg cccgctgggc tacaccgggc tgctctggct caacagcgcg
      121 acgttcctgg ccccgctcgt cgtgtggttc ctcggggtga acccggtggc cggccagaag
      181 cggtaccagt cggccccggt ctccttcgtc gcatcgctgc gtgccgggct gcgcatcttc
      241 tcccgcgggg agaagatggg cacgctgctg ctcctgatgg tgcccgcgag cttcacgttc
      301 tcgaccggca ccaccgcgct cttcgtcttc ctggcccgcg acgtgctgga cgcgtcgccg
      361 agctccatcg gcgtcgccct ggccgtggcc aacgtcggcg ggctcaccgg ggccctgatc
      421 acggccgaga tcccccggtg gaagatccgc accgtcaccg tgctgggcct ggccagcgcc
      481 ggcggggggc tgctgctcat cgcctccggc gcgggcctcg tggcggcgac ggcggccctc
      541 accgtcttct tcgtctgcga gaacgtcatc gcggtggcca cggagatgga gatgttcagc
      601 tccgtaccgc ccgagctgat cggacgggcc accgggatgt ggcggctggc aacgggactt
      661 ccgaccgccg cggccccttc ggcgatcgcg gtcctcggcg gattcctcgg ccctcgggcg
      721 atcttcgtgg ttctcgccgc ggtcaccgtc gtaccgctgg cctggctgct cggccaccgc
      781 tcggcgctgc gctacgagag cccggactcc ggggcccccg ccgaatccgc ggtgtccgac
      841 aactcggtgt gaagcttggg caagtgccct ttctgcgccg cctccagtgc tgacgggggc
      901 ggcgcttccg cgtgtcaccg gccgtgcggc gagtatggac cgggaggcgc gtggtgtgga
      961 tactttttct agaaatacgt tctagttgat ctgtgtcggc ccggagggtg gatacgatcg
     1021 cggggcaggc ccgccggacg gcttcggcag gcacgggcac cacacctgag cgagcgaagg
     1081 caaggcgggc gatgtctccc aagcaacaac gtggcgaagc gaccgccgac ctgctgctga
     1141 ccaccgcgtt gcgcgtgtac gcggaggcgg gccggcaggg cttcacggtc aacgccgtca
     1201 cggccgccag cggcgtcagc ctgggcagtc tctaccacca cttcggcagc ttcgacggac
     1261 tggcggccgc gctctacacc cggtgcatgg agcaactgct cgacgagatc gtaggcgccg
     1321 tgaagcgctc gcgcaccgca cgcaccggcg tccgcgcgct cgtcctggcc tacctgcgct
     1381 tcaccgaaga gcaccgggac gccgcgctgt tcatccacgc ctccgcctac tccggctacc
     1441 tggcggcgca cgccgaggag atccgtgcgg ccaaggccgc caagctgagc ggcctcggcg
     1501 agtggctgcg gccgcgcatg gaggccggcg agatcatcac gatgccgccg gccctgatcg
     1561 aggtcctggt catgggcccg gtcgcggagg ccgcgcgccg ctggctggcc agcacctacg
     1621 acgacatcga cctggccgag gcggcacgca ttctgcccga cagcatctgg cgttccttgc
     1681 gcccgacctg aggaggacag ccgggggcgc tcgctccggc cgggggtgag ggcggtcgtg
     1741 accgccctgg tcagccgttc cgtcagccgt tcgtcttgag gcacgtccgg tcgcccgccg
     1801 ggagctcgcc cgtggccagg taggcgttga cctgccggtc cacgcaggcg ttgccgtact
     1861 cgaggtagac cccgtgctgg ttggcgccct tgagcgtgat gagcttggag ccgggcagca
     1921 tgccgtggag cgcgcgcccg ccctcgtagt cggtacgcgt gtcgccggtg gcggccacga
     1981 tcagcgccgg ggcgtcgtgc tgcacccgtg tgggctcctc gcgcgggcgg tcccagaagg
     2041 cgcacgggcc gatgttgttc gtgagcgggc cgaacagcgg gtgggcggcg cggctgcgct
     2101 cgatgtcgcg ccagtaggtc tcggggtcgc gcggggcggc cccgtccccg cagaggatgg
     2161 ccgtctgcgc gctgccgtac tgcgaattct tgtcggtcag catctcctgc agcgtcttct
     2221 tgagctcggg ggagagcggc gcggactggt tgtccgccgc cttggccagg gtggacacca
     2281 ggtcgccgag ctccgctcgt gcgctgtcgc tgtccgacga gagcccgccg aagagcaggg
     2341 tcggcacctg ggtgtcgtcg agcgggaagg agtcgggggc cgtgccgagg gtcagcccgc
     2401 gcgcggacgc cttgacgatg cggtcgacgg tggagagcac ctgggcgcgg gtgcggccga
     2461 ggccgtaggc gtcgtgcttc ttcgccgccc aggtcgccca gtcggcgagc gcctgctcgt
     2521 tctccttctc gacgccccgc agcagccgcg ggttgtagcg gcgcgggtcg atcgccccgt
     2581 cgaggaccat ccggtcgtag cggccgggga acagctgggt gtagacggtg cccaggtagg
     2641 tgccgtacga gtagcccagg taggagatct tgcgttcgcc gagcgcgccc ctgatgacgt
     2701 ccatgtcgcg ggccgtgttg cgggtgttga tgtgcgggag catggaggcg ttcgtggcgc
     2761 ggcacttcgc ggccaggtcc ttgtgcaggg cgacctgccg gtcgaagcct tcccggccga
     2821 ggccggccga gtagatggag tggcccacgg gccagtggca gtcgagcggg gtgctgcggc
     2881 cgacggcgcg cggatccatg ccgatgatgt cgtagcgcgc accgacgtcc ttcatggcct
     2941 tgcgcatgtc cggcgggtcg ccgagggcgg ggccgccggg accgccgaag ttgatcagca
     3001 gggggcccac gcggtggcgg gtgtcggtgg ccttgagccg ggatatcgcg acggtgatcg
     3061 tacggccgcg ggggtcggcg tagtcgagcg gcacggtcac gtccgcgcac tgtgccccgg
     3121 ccttgtccag gtcacggccg gtggtgtcgt cggggccctt gatgcagctg cgccagtcga
     3181 gacgctgctg gtagtagcgg tcgagaccgg cctcgggcgg tgccgcggag ggctgcgcca
     3241 cgggggccgt gcgcgcggag gcgaaggccg ccggggccgc ggtgaggcag gcggtgaggg
     3301 cgaggcccgc ggccgaggcg cggcgcgcgg cgacggggct gagaagggtc acggggtctc
     3361 cttgatgtgg ctcgtgggac ctgtggtgtt gacggagctt gtggtgtggg cagagcccga
     3421 ggggctgacg gaacctgtgg tgccggcata gcgcgaagag ctgacggaac ccgagggatt
     3481 gctgcggtcg gcgcagaacg cggtgttcac gacggcacgg aagtcctcct ccgcccggtc
     3541 ggtaccgggc acctggttga gaacgagggc cacgctccgg ccgccgggcc cgaccgcgcc
     3601 cagcgcccgg tggccgccgg gcaccgttcc gccgtgcccc caccaccagc cgccgcactc
     3661 caggggcgag gcgatcaggc ccagcccgta gcgggcgccg ggccagagcc ggtcggggtc
     3721 ggcgggcacg gtgcgcttca tctcgtcgag ccaccgcgcg ggcagcagct tgccgccgaa
     3781 cagcgcaccg tagaaccggt tgacgtcgga gggcgtggag atcagcgcgc cgcccgcgcc
     3841 gccgaaggtc acgttccact cggtaccgtc gatccggggc gacggcgtgc cgtccggtgc
     3901 gccggggccg gtgaagtaac tgcgcgaatg cgggccgcgg atgcgcgtct cgtcgcccgg
     3961 ccagtacgtg tcgcgcaggc cgagcggttc gaggatccgg cgggtcacct ccgcctccac
     4021 gccgcgtccg gtgaccttct cgacgatgag cccggcgatg agggtgttgg tggtcgagta
     4081 gtgccacttc ttgtccgggc ggggcagctc gagcgcggtg gcgatcagtt cgcggggttc
     4141 gaagtgacgg taacgccact gctccacggg cctgtccacg atggcttccg agtggtcggg
     4201 aagtccgctg gtgtgctgga gcagccggcg cacggtgatc ctgcggccgt cgtggccgtt
     4261 gccccggatc agccccggca ggtagcgctc gaccggggcg tccagcccga tccggccctc
     4321 ggcggcgagc tgcacgacga ccgtggcggt gaaggtcttg ctgatgctgc cgatccgcag
     4381 ccggtcctgc gcgttcatcg gccgaccgga gccgaggtcg gccacgccgc gggcgacgtt
     4441 ccacttgccg caccggccgt cgtccacttc gacggccgcg cccggaatgc cgtggcggtg
     4501 cgtgagggtg tccagggagg cggccaccgc gctgcgtgcg gtgtcgcatc cgggggaggg
     4561 agcggggcgg ggcacggtcc ccgccgcggc ggccgagggg gtggcgaggc ccgtcagagc
     4621 gatcgccgcc acggcgaacg atgcagcacg acggctgcgc aagcggcctc gtaagcgact
     4681 tcctacggtg gtgttgctct cgctgtgccg tacgcgtgtc atacaccaag acgctagtga
     4741 ggcgcccgcc cgggatcact ccggctggcc cccgtattcc gtcgggggtc tgctccacca
     4801 cgggcttccg gcgggctggg cgaggtcgaa gggggccggg gcacggccct cccagatccg
     4861 gcgggaggcc tcttccggat agggcacggt cttcgattcg gcgtccagga cgcgcgtcag
     4921 ccgctgacca gggaggtagg cgggccatcc tgcgtctccg gtggtgacga agcggaccca
     4981 cgcctgctgg agttcgcgcg ataccgcgac ggctccgggg gtggacccgt cgccgaggag
     5041 tcccctgccg gcggggctgt ccggcgtgcc gaacgccaag gggacgtcga ggctgtggca
     5101 ggcgcccagg gccccgccga aggcagggga ggacagttgc agctcgaaca ggaaggaggt
     5161 gccgccggcc gccgcgttcg cctcggccag ctgcagcgag ggcatccgga acagggcgtc
     5221 ggagtagacc gattccagca gctcctgcgc ggtggcccgg gggagggcgg cccggtaggc
     5281 gtccgcgccg tccggtgccg gggcgaacag gtccagggcc gtacgggcgt cctcgtcggt
     5341 gaaggtgccg tgccgcccgc tcatgatgct gaacagccgg aactcgtcgc gggtatggcc
     5401 tacgaggagc tcggtcgcgc tcgcgcggcc gccggtgagg gcgggccagg gcgtttcggg
     5461 aaggacttct ccgtcgacga cggggcccat ggcgaccccc gtccgggcga gccgtcccca
     5521 gcgcgcgcgg aggccgggca ggccggcgct gagggaggtg agttcgtcgg cgaggagccc
     5581 gggttcgatt tcggcgaggg cggcggcggt gggcgccgtg ccgagccggt ccgcgagcgc
     5641 tgcagcgacc tctccggcca gggcgcgggt gcagtagttg cccggcaccg agtgggcgac
     5701 ggcccgaagg aacaggccgc gggccggctt catcgtcagc agggcggcga ccgaccccgc
     5761 cccggcggac tgcccggcga cggtgacacg gccggggtcc ccgccgaagg acgcgatgtt
     5821 ccgctgcacc cactgcaacg ccgctatctg gtcgaggaat ccgcggttgg gcggggcgcc
     5881 ctcgaggagg gcgaaaccct cggcaccgat ccggtagttg atgctcacca cgacgagccc
     5941 cgccccggtc agcgccgccg ggtcgtacag cgggtcactg gaagcccccg cgacataggc
     6001 acctccgtgg atccacacca gcaccggcag acccgccgcg cccggatccg gagtgctgac
     6061 gttgagcgtc agccagtccg tgcctccccc cgggttcgca cgcacagggc cggactgcgg
     6121 tgccgcgggc ccgaactccg cggcctgcct ggtcccttcc cagggcaggg gaggggcggg
     6181 cgcggcgaac cggagcgctc ccaccggcgg ccgggcgtag gggacgccgc ggaacactgc
     6241 gtgtccctgc cgccaacggc cctccagcag accatcggtg gtgcgcacgc tgggctgttc
     6301 gggcatgtcg cttccttcct ccgcgagggc ctcccggcgt tatcggccaa aggctgtaca
     6361 cgggaaacga gtagggcggg acaggccggc acggccttgg gtccggtcag gctccggtgg
     6421 gctccggtgg gctcctgagc ctgtagggcc tgcgccaccg ccttctgcat tccgccggtc
     6481 gtccggggag ccgacggcgc caagcggccg accacgcgcc tcagccgttc cacgtcggcg
     6541 agccggtgca cgtcgcccgc ggcgacggtc tgccccagcg gatcacatgc tccgcaaacc
     6601 gggcctgaag gggcggtcgc cggacccgtg gttacggatt cggccgcggg tgtgggtgct
     6661 gtgcacgtgc gtctcctctc cggccggggc caccgggcgc ggttcccgga ctgcatgctc
     6721 gctcggagcc gcgccgcacg tctacgggcc cgatccggcc tgtgaacccg gcctgcgacc
     6781 ccggtgcgac cccggcctgc gaccccggcc gggcggccgt cagggccacg ggtagccgag
     6841 cgcctcggcg gactcgcggc tgccgcccct gacctccgcg tagcccttcg ggtcctccgt
     6901 cgagagacgg tgcagcgccg cggcggcctg ctcctccggc ggtgtgccgt cgtcctggag
     6961 gtcccagatg aactgcaggt aatggccgtc cttgtcctgg cgcccggcgg cggtccccgg
     7021 ccggaacgtg aaggacacgg cgatcgtgtc gggctcgccg aagtcggtgc cggcccagtc
     7081 caggcgggcg tcccaccggg cgaggatgcc gggccggtca cgtagtcctg cagcaatgag
     7141 ccgcgcggcg ttccgggccg gccaggccca ggagcggtcg gtctccgcac gcgcgatctc
     7201 ggcgtcgtag gcggcggcgt cgaagcggta ctcggggagc tcgggtgcgg gctgccgggt
     7261 cggcagggtg tgcgggcggc gccagtcgcg ccacaccacc tggtccccgt cgcggcagat
     7321 ggtgacgtgg agcgcgccgc agcagccctc ggtgcagtac gcctcggcga gctgcacttc
     7381 ccggggttcg gccgcggccc gtaggcggcc ggtgtcgagc aggtactcgg gggagtgggc
     7441 ggggccccgg ccgaaggcct cgggcaccag ggggcggccg tcgatcagga gccgcgtctc
     7501 gacggattcc gggaccgccg ggtcgcgtac gacgacttcg acgcggagcc ggcccggagc
     7561 cgccgggcgg gtgaagggct gccgtgcggc gcggcgcatc cagtggagcc ggcggcgctc
     7621 gccggggtcg gtgggttcgc cggccggtac ggcggtccag gcaggtgaag tcagtacgga
     7681 ctccagagtc tccaggagcg cttcgcgctg tccggtccgc cagtcgagga gaacgctcgg
     7741 cccgctgtgc agatcgaggg cgacggagag caggatcgcg tagtggtcga ggccgggagg
     7801 cagccgggag gcgcgggtga cgaaggcctc gtacgcggcg acggcccggt cgtaggcgag
     7861 gacctcgtac tggtagtcgt ccgcccgcgc catcctgacc aggaggcgtc ctgcctgggc
     7921 cagggtgggg gcgtcgacgg gatcgtcgcc gatgatgtcg tcgagcatga cggcctccgc
     7981 gattctgcgg gcggtttcgg accccacggc acgggggtcg agggggacgg tcagcagccc
     8041 gtcgcgggcc gcccggtcgt cgcgggcgag cagggcgtcg accaggtggc gcagctcccg
     8101 gccctcggtg taacggctca gccacacgag ggcgccggtc gggcagtcga tggcggtgag
     8161 ggccgcgacg accgggcggg tgaacgtccg gaaaaggccg aggaccgtga ggcaggggat
     8221 gtcctccggc tcgccgaggc gcgccaggag gccgagaccg acgctcacgg ccggtgcgct
     8281 cgtgcccgta cggaccaggc ggcggccgag ggcgcgggct gccgcttcgt ccttcagggg
     8341 cagctcggcg agggcgtccc ggagggggga gacccgtgtg ccgagtgcgc ggaggcgacg
     8401 gtgcacttcg tcggcggccc ggagggtgtc ggggtcgctc agcagcgggg cgatggcgtc
     8461 cgttgcggcg gctcgggctt cagcccagcc gaggttgccg ggctgcgggg tcgcagccgg
     8521 tgctgccgag ggcgaagccg gggccgtatc cggggccgta tccgggtccg gcaggcggta
     8581 gccgcgccgg ggagggcggt cgtcgggctc tgcgtcccgc aggcgcaggg cgtaggcgta
     8641 cagggaggtc cgaggggtga gcgcggcgcg ctcttcctgc gggctcacca ggcggggtgg
     8701 gactcgattc cgtaggtcat gcggaggatc ctgccaggcc cgcagggcct cctgccaggg
     8761 attttcccgg gaccggtgac ggcctcgtgc gcttcggctc tgcgcgacgc gccgccgcgg
     8821 ccgattgtca gtccccggtc ataaggtgcg cgacatggct tcagagatcg tctacgagca
     8881 cggggacgcg acggccccca ggggctccgg cccgcgcatc atcgctcacg tctgcaatga
     8941 ctccggcggg tgggggaagg gcttcgtcct ggccctctcc cggcggtgga gcgctcccga
     9001 ggccgccttc cgccggtggt acagggaccg gcagcgcaac gacttcggcc tcggggccgt
     9061 gcagtacgtc gaggtcgagc cgggtctgtg ggtggccaac atggtgggtc agcacggcat
     9121 atgtaccgcc gcggagcgcg cggccggcgt cggcgtcccg gtgcgctacg aagcgatcga
     9181 caccgccctg gcctccctgg gggacaaagc cctcgccctc ggggcctcgg tgcacatgcc
     9241 ccggatcggc tgcggcctgg ccggtggccg gtgggacacc gtggagccgc tcgtcacgcg
     9301 caggctgacc ggccgcgggg tgccggtcac cgtctacgac ccggcctgac cgtccgcatc
     9361 cccgggctcc ccgggctccc cggcgccctc cgcatcgccg cacaggacgt tggccgtgcg
     9421 cacggtctgc cagcaggggg agcagagatc cagccaacgc ggcccgtgcg tgtcggagtt
     9481 gacgacagcg gcgcaccggg cgggctgccc gcagccgagg cacaggtgcc gtccctcgcg
     9541 cacgcggagg tggaggtccg actcgtccgg gtcggcgggc gcgctcgcga gcagcgtggg
     9601 ctcggcggcg atgaggtgga gcagccctgt ggcggtcgcg gcgttcaccc ggcgaccgta
     9661 cggcacgcac acttcgggac gccatccttc acatagtgaa cacaagccct ccagggcggc
     9721 ggtgcggcgc gttcgccgac tttgacaggt tcacgcaggt aaggggaatc ggcaccctcg
     9781 cccgcccctt cgcgagtgat tgatctcttg aacctttcgc actccggaac ccttgcttca
     9841 ccttgagcga cggtagtagc ttcgtattga aatgatcttg aacgccgctc ggtagcggcc
     9901 gatacgcacg tgcgcccgcg gctgcgaccg caaccgccgg ccgcccgccg ccggtgccgc
     9961 cgatcccgcc gagccgagct ccgaaagaga gattcgctgc atggttttcg cttcccgcag
    10021 tcagacctgg caggtacgga gtcagcagac gatcgcctac gagatcgtcg agacgcgggg
    10081 gctcctggac ccgcgcaacg acggcctctt agcggtcccg ggcggcggcc gcgcggccgg
    10141 cacccgcctg gtggtcctcg accacagcat cgacgccctg tacggcaccc gcatccgcga
    10201 ctacttcgcg caccacggcg ccgaggtcga gtacctgacg atccagggcg cggaggagaa
    10261 caagaacatc gagcaggtga tgcaggtcgc cgacaagctc aacgaggtcg gcacgcaccg
    10321 cctgagcagc ccgcccctgg tcatcggcgg cggcgtggtg gccgacgtcg tgggtctggc
    10381 ggcgagcctg taccggcgcg gcataccgta cgtccgcgtc cccaccaccc tcctggccca
    10441 ggtcgacgtg agcgtcgcgg ccaagaccgg tatcaactac ggcggttacc gcaaccgcct
    10501 gggcagctac agcccgcctc cccgcacgct catcgaccgc gagttcctcg ccacggtccc
    10561 cgagcgggag ctgaggaacg gcatgggcga gatcttcaag atggccctca tcaaggaccg
    10621 ccgcctcttc gagctcctgg agacgtacgg cgcagcgctg atcagcgcgc gcttccagga
    10681 cccggccgcc ggtgacgacg gcgtggaggg cgtggccggc gagatcgccg acgaggtgat
    10741 cgggcgcgcg atcgcgggca tggccgagga actggagccc aacctctggg agaagaacct
    10801 cgagcggtcg gtcgactacg ggcactcctt ctcgcccctg gtggagatgc gcgccatccc
    10861 cgaactcctc cacggtgaag ccgtggccat ggactgtgtg ttctccgcgg tgatcgccgc
    10921 gaaccgcgag ctgatccccg ccgcggacct ccagcgcgtc gtcgccgccg cgcgccgcct
    10981 cggcctggcc ccctcccacc ccctcttctg cgacacggac ctggtcctcg aagccctgga
    11041 ggacaccgtc cgtcaccgcg acggccggca gaacctcccc atgctgaccg gcatcggcca
    11101 ggtccgtttc ctcaacgacg tgaccgaggt ggagatcaag caggcctgcg aggccatggc
    11161 ggacctgctg gacgcagttc ctgcctcctc tacctcccct gcctcccccg ccgccgaggg
    11221 ccgccggtga gcggcgaccg ggtcgtcctc gtcacaggag ccagcgccgg catcggccgc
    11281 gaatccgccg cggcgttcgc ggaagcgggt atgaccgtgg tcctcgccgc ccgcaacgaa
    11341 gagcgcggcc accgggccgc cgaagagatc cgcgccgggg gaggcgacgc gcagttcttc
    11401 cgctgcgaca tcaccgaacc cgacgacgta cgcgcgctgt tcgcccgcat caccgccacc
    11461 tacgggcgcc ttgaccacgc gttcaacaac gccggcgtgc ccggcgacgg ccgcctcgtc
    11521 gacgtgtcgg aggaggactt cgaccgcgcg ttctccgtca acacccgggg actgtggctc
    11581 tgcctgcgcg aagaactgcg gctgatggcg gagcagggtc acggaagcat cgtgaacaac
    11641 acctcggtcc acgggctgcg gaccgtgttc cccggcatcg gggcgtacgt ggcgtccaag
    11701 catgccgccg tggccctgac gcgcgtcgcg gcgctggaac acgcccgcga cggcgtacgg
    11761 gtcaacgcgc tggcgccggg ccccatcgag accgagatgc tcgccgcgtc cgaggcggcc
    11821 gtgggcgggg cgaccacctg gcggggcctg atcccgtcgg gcgagatcgg caccccgcgg
    11881 caggtcgccg acgtggcgat gtggctgttc tcgccggcgt cctcctacgt caacggtcag
    11941 accatcggcg tcgacggcgg cttcctggcg gtctgagccg ccggcctccc ccccgatctc
    12001 ttcgctctct tcgatctctt tctgcagatc tctctctgct ctcccccaat ggaagtggtt
    12061 ccatgaaaac cgacggtgtc catggtgccg gtggcaccta tgacgtcatc gttgtcggcg
    12121 caggcgcagc cggaagcatc gtcgcggccc ggctgagcga gcagcgcgac agatcggtcc
    12181 tgctcctgga agcgggcccg gcggacgacg acccggcaat cgcccgcccg gcgtcctggc
    12241 cgttcctgct gggcggcgaa ctggactgga agtaccggac ggttccgcag gacgcgctcg
    12301 ccggccggcg cctcgcctgg ccgcgcggcc gcgtcgtcgg cgggtcgggc gccatcaacg
    12361 ccatggtgca cgtccgcggc gcggcctccg acttcgacgc gtgggcccgc tggggcggcg
    12421 ccatgtggga cgcgcagcac gtcatgccgt acctcgaagc cctggagggc ccggcgggcg
    12481 cgccgcagta cgggcggatc cccgtcgcgg agaacaccgc cccgcacccc ttcgcggccg
    12541 cgttcgtcgc agcggcggag aagtacggcc tgccatccaa cctcgacttc aactccggtg
    12601 tgcaggaagg cgtgggcctc taccgcacca cgcgcaccga cgacgcagaa cccggccccg
    12661 gtcggacgac gcccgcgacg cccgcccgcc gcggcaacac cgcgcacacc cacctccgcc
    12721 cggcgctcga ccgccccaac ctcaccctgc tcaccggcgc caccgtcacg gccgtcgagg
    12781 tcgaggacgg gcgggccgcg ggcgtacgga tcctgcgcga cggccgcgtc accaccgtgc
    12841 gctgcgcggg cgaggtgatc ctgtgcggcg gcgccgtcgc cagcccccag ctgctcctgc
    12901 tcagcggcat cggcccggcg gccgctctgg ccgcgctgga catccccgtc gtcaccgacc
    12961 tgccgggcgt cggggccaac ctgcacgacc acgtccaggt gtccctcgcc tacgacacca
    13021 ccgagggccg tcccgtcgcg gacttctcca acctcggcga ggcgggcggc ttcgtcacgc
    13081 tgtaccccgg ctccccggcc ccggacgtcc agctgtcctt cgcgcccatg aaggacctga
    13141 acaacggctc cgagctcggc cgcggcttca ccgtcggccc gggcgtcacc cgcccgcgca
    13201 gccgtggcag cctcaccctg gcctccgccg accccacggc ccacccgctg atcgaccccc
    13261 gctacctctc cgacccgcac gacctcgaca ccctggtgga gggcgtgcgc atcgcccgcg
    13321 acatcgcggc gacggccccg ctgtcggact tcgccgcagg cggcccgctg agcccggcgg
    13381 ccacgcgccg cgagctggag gacttcgtcc gggcgaacgc gcagacgcag ttccacccgg
    13441 tcggcacctg ccggttcggg caggaggcgg acggcatggc ggtcgtcggc ccgcgcctgg
    13501 acgtcagggg ggtcgccggg ctgcgcgtcg cggacgcctc ggtcatcccg aacatgatca
    13561 ccggaaacat ccacgccgca gtggccgcag tcgccgagcg cgcggcggaa ttcgtacagg
    13621 aggacctggc atgagccctg cacccacccc cgcacccgcc cccctgcgct ggggcgtgct
    13681 cggcgccacg tcctacatcg ccacgcacct catgccggcc gtcgccggga ccccgggctg
    13741 cgagctcacc gccgtcgcca gccgccccgg acggaccgag caggccgcga cggccggcga
    13801 gccgttcggc gccgccgccc accgcgacta cgcgtccctc ctcgccgacc ccgccgtcga
    13861 cgcggtctac atcgccctgc ccaacaccga ccacgtcgag tggaccgtac gggccctgga
    13921 agcgggcaag cacgtcctgg tcgagaagcc catggccatg gacgagaagg gctgtgcgcg
    13981 catcgaggcg gccgcggagg cctcctcccg tacggtgatg gaagccttca tgtaccgctt
    14041 ccacccgcag caggcgcgcg ccgccgagct gctcgcctcc ggcgcggtcg gcgaactgcg
    14101 cgtcgtccgt gcgtcgttcg ccttcgccat cgagaccgga agcggcaaca tccgtctcga
    14161 tccggcgctc ggcggcggcg ccacctggga cgtcgggtgc tacgcgatcg acgtgcccct
    14221 gttcttcttc gggcaggccc ccgagcgcgt ctcggcccgc ttcggccggc ggccgggcct
    14281 ggaggtcgac accagcgcgg tggcgaccat ggacttcggc cggggccgca gcgccgtcgt
    14341 cgactacagc atcgactacg ggccccgcgc ctggtacgag ctccagggca cccacgggac
    14401 catcaccgtg cggaacgcct gggccatgag cggggaggac ggcgtcatca ccgtgctcac
    14461 cgcggacggc gtccgggagg agacggtgcc ggccgcgaac cactaccagc tgcaggtggc
    14521 ccacttcgcc gaagtcgtac gcgcgggcgg cggcgcgggc tcgggcgtcc gcgtcccgct
    14581 cgcggactcc cggcggacgg cgcgggtggg ggagtccctc gtggcctccg cggctgcgga
    14641 cggcgcgccg gtgccctgcg gtgacgaagg cccggcgccg cagtgacgca gacgcatgtc
    14701 cggtcgtcgc cgctccgggc cttcacggtg ctgctgacct cgctcggagg gctcctcttc
    14761 ggctacggca cgggtgtcat cgcaggagcc ctcccgctgg tctcccgcac ctacgacctg
    14821 tcgtcgtggg cccagggcgc ggcggtgtcg gcggcgctgc tgggagcggc cctgaccgct
    14881 cccaccagcg gccggctggc cgaccgcctc ggccgccggc cggtcctggg cggcgccacc
    14941 gccttctacg ccgcgggcac gctgctgtcc gcgaccgcgg agggcccggc gtcgctgctc
    15001 gtggggcgcc tcctggtggg gctcgcgctg ggggcgacgt cgttcgccgt tcccctgtac
    15061 atctcggaga tcgttccgcc ggcccgccgc ggtgcgctgg tgacggtcaa tcagctgatg
    15121 atcaccgtgg ggctgctgct gtcctacgtc gtggcgtacg tcctggagtc ctccgggaac
    15181 tggcgcgcga tgttcgcgct cggcgccgcc ccggccctga tcctgctggc cgggctcccc
    15241 ttcgtccccg agtccccgga gtggctgcac agccgggggc aggcggaccg cgcggcccgc
    15301 gaggcgcacc gcctgggcct gccggtccgg gccgcggacg acgccccgtc cgccgcccgg
    15361 gggttcggcc tgcgggcggc cgcggcgcac gcggggccgc gctgggtggc actgggcctg
    15421 gccatcgccg tcctcgtcca cctcaccggg ctgaacacgg ccatctacta cgcccccacc
    15481 atcctcgccg acagcggcct gacgtcgagc gggggcgtcg ccggttcggt gctcgtgggc
    15541 tcgtgcaacg tcgtggcgac cgtcttcacc atcgtcttcc tcgacaggtg ggggcgcagg
    15601 cccctcatgc tcggcgggct ggcggtgatg gccgccgcag ccgtggcgat cgcgtccgtc
    15661 cagagcctcg gcgacccggg cgtggccacg gccgtcctgc tgtgcctgtt catcacggcc
    15721 ggagccgtcg gcccggccgc ggtgttctgg gtctacatcg ccgagatcta ccccgcccgc
    15781 gcgcggggcg ccctcatgag cctggccacg gcggcgcact ggggcgcgga cttcgtcgtg
    15841 gcgacgacgt tcctgccgct ggtgcagggg ctgtcgctcg aaggcgcctt cctcgtctac
    15901 gcggtgatca cggccgcctc ggccgtgggg ctggggaagt ggatgcagga gacgaagtcc
    15961 gcacccgcag ccactgccga aatcgcaacc gtatccgtgc ccccggcccc tgttgccaca
    16021 gctcccaccg ttcccatcgt tcccaccgtt cctgctcgtt ccgaccatcc gctggaaaca
    16081 gagaggtgat gtcccccatg catcccgacc tcgcaccccg caacgccgcc tgcctgctct
    16141 tcgattggga cggcacactg gtggacagcc agtacaccaa ctaccgcgcc atggccgccg
    16201 ccctgcagca ggagggcgtc gacctcgctc aggactggtt cgacgcccgt accggcctgt
    16261 cctcggccga gatgatccgc gcgctgctcg acgagcgcgg gctgggcctg ggccgccccc
    16321 tcgaggaggt cgtcgcggcg cgcgacgcgc tgttcctcga ggaggcgcac accgtacgcc
    16381 cgcacgcggc cgtcctggcc gtggtggagg cgatgaagca ccgcctcccg atggcggtgg
    16441 cctcgggcgg ggcccggcac atcatcgaga ccacgctgaa gcaccagccg ttccacgacg
    16501 ccttccaggc cctcgtcacg cgtgacgacg tcgaacgcgg caagcccgcc ccggacatct
    16561 tcctggccgc ggccgaggcg ctcggggcgc acccctcgcg ctgcctggtc tacgaggaca
    16621 gcgacgaggg gatcgccgct gcccacgctg cgggcatgcc ggtgatcgac gtgaggccgt
    16681 tcacacgtcg ttgacctgca cggacgaagc tgccgtctgc ccggcctgct gggccgggat
    16741 gcggcgtacg cattcgatga ggtagtcgcc gctgtccggg tcgagggtga cgccgtgggc
    16801 ctcgctgtgg aagccgggga agcgccggtc gaaggattcc agggccttga ggtagcacag
    16861 cagcgggccg tcctgcgtgc cggtgttctc gccgggcatg aggacgggga tgccgggcgg
    16921 ggtgacggtc accatggcgg cggccacccg gcccgccgcc tcggccaggc gcacccgctc
    16981 ggtgccgccg cggatgaggc gctggtagca gtgctggggc ggggtgacgg gctcgggcag
    17041 gtcctggaag gcggtgtcga gcagttcgac caggtccgtc tcgcgcaggt ggtcgtgcat
    17101 ctcctggcac agcccgcgca gggttcctcc ggtgtagcgc tgagggtgcg cctcgaccag
    17161 ctccggcagg acgcgctcca gcggcgcgtc ctcgtcgtag agcgtcttga agtccatcag
    17221 ggcgtccatg agcgtgcccc acttgccctt ggtgatcccc atggagaaca ggatgagcgt
    17281 ggtgtagctg tcggtcttct ccaccacgat gttccgggtg gccaggtagg cggtgaggac
    17341 gcgggccggg atgccccagt cggacatccg ccccgaggcg tcgatgcccg ggcaggtgag
    17401 ggtgaccttg acggggtcga ggaggcagta gccctcggtc aggccgggga agccgtgcca
    17461 gtcggcgccg ggctccagct gccagcagga cggttcggtg cgcagcagtt cggcgggggc
    17521 gtcggcgaag gacacctgct cgccggtggc ggggtcggtc accgcctcgg gctgccagac
    17581 gccgaagaac cagccgggcc ggtcgccggc ggccgcgatg cgccggccga tgcggacgac
    17641 cgtctggcgg aagcggacgg cctcggcgac cgcctcgtcg atcagccagc ggccctgcgg
    17701 cccgtccatc atcgccgcgg ccacgtccag ggaggcgatc atcgggtaca gcggcgaggt
    17761 ggtgccgtgc atcatgaacg cttcgttgaa ccgctcgtgc tccaccggcg cccgcggcgc
    17821 gggcttgacg tgcaccatcg cggactgcga cagcgcggcc aggagcttgt gcgtggactg
    17881 ggtggagaag acggtgggcc gttcggcccc ggggaaggtg tcggggccca ccgccatgcc
    17941 gtagcgcccc gcgtagaggg ggtggaaccg ggcgtaggcg aaccaggctt cgtcgaagtg
    18001 gagccggggc gtgctgggcg cgagggcccg ggcgacctgc agcgcgtcgt aacacagccc
    18061 gtcgtacgtg gagttggtga gcaccgcgta ctgggcgtcg ggggagaccg ccccctgggt
    18121 cagcgggttg cgggcgatcc gcgaggcgac cgactgcgcc tggacctcgg cgggcggcag
    18181 cgggcccgcc agcccgtatc cgttgcgtgt gggcaccagg tagaccggcc gcgcgcccga
    18241 caggaccagg ccgtgcagga ccgacttgtg gcagttgcgg tccaccagcg cgatctcgtc
    18301 gcgcgtgacg ctgaagtgac cgaccatgcg gtcgcacgtc gagtcgccgt gcaggacgaa
    18361 gtaggtgcgg tcggcgccga agatgcgggc ggcgttgcgc tccgccgcac cgaccgggcc
    18421 ggtgtgctcg aagagcgacc cgagctcctc gaccgagatc gacaggtcgc tgcgcagcag
    18481 ccgttccccg aagtggtcgt agaaggcccg gccgaccggg gacttcagga aggcgacgcc
    18541 gccggagtgg gcgggggtgt gccaggagta ctcgtgcgtg tcgtcgaatt gccgcagcgc
    18601 cttgaagaac ggcggcagca ggtcctcctg gtagccgcgg gcggcccgtg cgatccgccc
    18661 ggcgatgaag ggcgcggtgt cctccagcgg ccagatgtag ccgacgacgg tctcggccac
    18721 ccacagaggc aggtggtcga ggtcctcgcc ggccgtgatc aggaagaccg gcaggttccg
    18781 gaagcggcgg cccacctggc gcagcacacc ggcgccgccc gggtcgccgc cttccgtgcc
    18841 gtcctccttg ccgccttcct tggcgtccgt cttgccgtcg gccttgccgc cctccccgtc
    18901 ggttccggga agcccccagt cgacgacggc ggcggccagc ccggcctcgg tgcgcagcac
    18961 cgcccgggcg tcgtcgctcg tggaggccca gcgcacttcg taaccggctg cctccaactc
    19021 attgtgaatc cggcgtagtt gctcggctcc ggtgcccccg tccccggagt tctcccgtac
    19081 tgcgaacaga accgtcccgt ctgtcatggc gcccccctgc tgctctgctg cgatgtctgc
    19141 tgcggtgttc gagaggtaat cgcaagaaca gggggagcgg cgccgcgacc gggccgaaac
    19201 caccccgatg agggaaacgc cgactccggc ggtgagcctt ggacttggac ttggacttgg
    19261 actgctgcgg ctacggctac ggctagggct acggctcgaa gtgcagggcg cgtaggagct
    19321 cgccgtcgtc ggcccggtgc gcccgctcca gcatgcggcg caattccggg ccgggcacgg
    19381 gttcgtacac ggtgacggtg agggtgaccc cgtcgcgctg cagcgacagc ccgtcggcgg
    19441 tgctcccgtc gcccagcttc cgggtgacgg aagtgaagcc tccgccgagg tccttgcagg
    19501 tggcggggcc tggcagggtg tggtcggcgc agggggaggt gctgccgggc gacacttcgt
    19561 actggaacgg ctgccgctgc gggttcttgc cggagccggt gtggcggtag ccgaggcgga
    19621 gccccccggc cgagatgctg ccgttgcccg cgtcgatctc gtacccgtca ggggcctcgg
    19681 gcagcagaag gtgctcccgg gggagcggcg aaccttcgag cagggaggcc agctccttgc
    19741 tccggtccgc ctcgtacccg gaccacacca ggaggaccgc ggtggtggcc atcaccgttc
    19801 ctgcagtggc gcgtacggcc cgggcgggca cggacagggc cgcgcacagg gcgtacggca
    19861 cgccgcacca caggaagagc gtcgagtcac cgcccaggcc gatgtcaccg gactgccggg
    19921 cgaggtatcc gagcgcaacc ccggcgctcc ctcccaggaa cacggcgacc gcccatccca
    19981 cttgcccgga ggtcgtgcgg cgcacgggcg gggcggcagg gcctgccctc atgtcccgga
    20041 ccggcagccc ggccgcgaac agcgccgcca ccatcaccgc gctcccggcc acgagcgcgc
    20101 ccaccgcacc gggcaggccc cccgcccacg cccacacgac gccgaccttc cacgcccagg
    20161 gcaccacgag cgccccggcg agccatgccg tgccgaggag gaatgccacc ggtgcccacc
    20221 gtgtccaccg tctgtctgct tgatccatag gacgatcgtg cgcaaacact cctcggagca
    20281 cctgagtacg cgtactcaga acgacgtgac aggccccctg tgaggggccc accggaatcc
    20341 ggcggcgagc gcagcgggcc ccgggccggt tccggccgcc gggcccgctg gtggaaggcg
    20401 cgatcctggc cctggccggc agcgacctgc tggcccggct ggtctcgcgc atcgagcacc
    20461 cgggcgttct cggcctctcg ctgctcgccc tcgcggggac cttcttcggc ggcccgttcc
    20521 ccgagacggg caactggcca cgggtggagg tccactgcgc cctggtcggc gcgggtcccg
    20581 tggtcctcgg ccggctcatg cgctcccggc gggagatcgc ggagcagttc gggaaccggc
    20641 acggtcccga cccggccgtg tcgtgacgtc accgcggccc cggccgggcg tcccgctccg
    20701 gtacggtgcg ccggtactca tgactcgtgg ggcccgccgg ggctccgtgg aggggtgaag
    20761 gatgaatgcg gcggcggacc cggacccgga cccggctccg gcgaacacag gcgggttgaa
    20821 gcggcggctg ggtgtcttcg acgccgtggt catcggcctg gggtcgatgc tcggggcggg
    20881 gatcttcgcc gccctcggac cggcagccgg cgccgccgga tccgctctgc tgcccgccct
    20941 tgccctggcc gcgctggtgg cgtactgcaa cgccacctcc tcggcgcggc tggccgcccg
    21001 ctacccggcc tcgggcggaa gctacgtcta cggccgcgag cgcctcggcg acttctgggg
    21061 ctacttggcc ggctggggct tcgtcgtggg caagaccgcc tcctgcgcgg ccatggccct
    21121 gaccgtgggg acctacgcgt ggcccggccg ggcccacgcg gtcgcggtgg cggccgttgt
    21181 ggtgctgacg gcggtcgact acacgggggt gcagaagtcc gcccggctga
//
