LOCUS       NZ_LNBE01000002        32870 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_2, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000002
VERSION     NZ_LNBE01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1142035)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 655534
            Orig. end                         :: 688404
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..32870
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /product="hydrogen-cyanide"
                     /region_number="10"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..32870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="neighbouring"
                     /product="terpene-precursor"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11083)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(397..412)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            complement(718..1278)
                     /locus_tag="AS857_RS04485"
     CDS             complement(718..1278)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486545.1"
                     /locus_tag="AS857_RS04485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_338058243.1"
                     /transl_table=11
                     /translation="MSQVRRGIMQALAWMLATAAAMAVSWYGVRTVLAGTAYEPPRALP
                     ISGTAAPAIGEPASSTRTPGPLPSPSPPGTASPSGKQLAPPAPDTSAPGSGAASGSAQS
                     PEAQAQPGAGEVKSYPVRGGRAVFDLGESSATLVSATPEEGWQMRVWKQSAWIRVDFMA
                     GTKTTSVFVTWNGHPPRVQTVEN"
     gene            1312..2034
                     /locus_tag="AS857_RS04490"
     CDS             1312..2034
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060929.1"
                     /locus_tag="AS857_RS04490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_063278413.1"
                     /transl_table=11
                     /translation="MARLLVVEDDPFVRSALIRQLTEASHTVRSVGTALEALREVAQVG
                     FDLVILDLGLPDLDGAQALKMLRGITDVPVIVATARDDEAEIIRLLTDGADDYLVKPFS
                     VAHLTARMAAVLRRSGRGGPAGEPAPSAALQVGGLSVDPLRRLAELDGAPLDLTRREFD
                     LLAYLAGRPGVVVPRKELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAASPRYLHTVRG
                     VGVKLEPPAAGTALPEQP"
     gene            2031..3455
                     /locus_tag="AS857_RS04495"
     CDS             2031..3455
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046167.1"
                     /locus_tag="AS857_RS04495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_058041782.1"
                     /transl_table=11
                     /translation="MRWALVRVSLAVTVMVVLAFAVPLGLVVKELARDRAFADAERQAA
                     QIRPALAITTDRDQLERAVASSQAGGDGRMAVHVPGNDDKQNGDKQNDDTQQGAGAEGH
                     KAYDIGPRRADPRDVETARRGRSAVTSVPGGYALLQPTALSTGEFAVVEVYVPHRAVGN
                     GVTTSWAILAGVGLGLIAGSLVTADRLGLRLVRPAERLAKAAAELGEGKLGVRVREDGP
                     AELRAAAVAFNSMADKIVQLLSNERELAADLSHRLRTPLTVLRLNAASLGEGPAAEQTR
                     AAVAQLEREVDQLIRAAREQGEQKERPTLGCDASEVIRDRMDFWSALAEDEGRTVRLSG
                     VDATVRVPVARPELAAALDAMLGNVFRHTPEGTAFAVDVHHSDDAVIVLVSDAGPGIAD
                     PDAALRRGHGAGGPGSTGLGLDIVRRVAESTGGDVRIGRSVLGGTEVRVWLSPDGGGSK
                     GRERRRRRVRRGRSRR"
     misc_feature    complement(3511..3528)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.17"
                     /tool="antismash"
     gene            3637..5115
                     /locus_tag="AS857_RS04500"
     CDS             3637..5115
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105712.1"
                     /locus_tag="AS857_RS04500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_058041783.1"
                     /transl_table=11
                     /translation="MGSSAHRRRVSRKAKLAGAGLAAAIATGAAFTLTGTAQAASVGAA
                     FSRTGAWSDGYTGQYVLTNDTGKDLSGWKLTFDLPAGAKITSLWNGKHTVSGRSVTVEP
                     ESWNATIAPGKSVTVGFVAAGSGVGAGAADAPANCRINGTKCSVDKDPGPQPSGSTGAT
                     GSTKPTDPTTPTSAPPQPQPQPTVTSPAPGGANAAFAPYVDTSLHPTYDLLDTAKKTGV
                     KNFNLAFVTSGGGCTPKWGGVTGIGSDPVAQQIGKLRAAGGDVRVSFGGAAGSELGLVC
                     SSADELAAAYGKVVDAYKLTKVDFDIEGAALPNAAANTRRAQAIASLQKKHPGLDVSFT
                     LPVMPTGLTQEGVDLVGNAKKSGVSVSAVNIMAMDYGSSFNGDMGQYAIDAATATQAQV
                     KGVLGLSDKAAWKAVAVTPMIGVNDVAAEVFKVDDAAQLAAFGRSKGIGWLSMWSAARD
                     KQCPGGAQNSASATCSSIVQDELAFTKAFAARKG"
     misc_feature    5251..5267
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            5251..6312
                     /locus_tag="AS857_RS04505"
     CDS             5251..6312
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578906.1"
                     /locus_tag="AS857_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_058041784.1"
                     /transl_table=11
                     /translation="MRTRHKAVRMTLLGAAPLALTALTAVPAEAHGSMTDPVSRVSACF
                     AEGPEHPRSAACKAMVAAGGTQPLYDWNEVNIGDAAGRHRQIIPDGKLCSAGRAKYKGL
                     DLPRADWPGSKLAPGKHTFRYRATAPHRGTFELYLTKDGYDPKKPLKWSDLEAKPFAKV
                     TNPTLKDGSYVFDGTVPKRSGRHLVYSVWQRSDSPEAFYTCSDVDFGGKGKAATAAQAA
                     APAASAPSDRQITEEAAKSTVDHGGHGGDGPGDSGHGAGGNGGNGHAEKSHGENGRAGS
                     DGKAGAGDVGAGNEPRSAVKAANAPAAQGGRLAETGGDDRTAMLAVAGAGVLAVGSATL
                     FLAVRRRSARNHA"
     gene            complement(6327..6896)
                     /locus_tag="AS857_RS04510"
     CDS             complement(6327..6896)
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004944067.1"
                     /locus_tag="AS857_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="universal stress protein"
                     /protein_id="WP_058041785.1"
                     /transl_table=11
                     /translation="MSRTVERVVVGVDGSAGSVAALRQGAQEAARHGAALCPVLAWSPP
                     GGEAADALQPAPADVRAHWEAQARRALTKTCERALGAAPFRLRVAPRIVRAEPGPALVA
                     SARHDTDMLVLGAGSHGLWHRFLHGSVSRHCLRHARGPVMVVHPDEADVKDARGAVRPP
                     RRHPPVVVPVGPTDTWHRPTGPGRNG"
     misc_feature    complement(7048..7061)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(7095..8108)
                     /locus_tag="AS857_RS04515"
     CDS             complement(7095..8108)
                     /NRPS_PKS="Domain: NAD_binding_4 (17-191). E-value:
                     1.4e-18. Score: 58.8. Matches aSDomain:
                     nrpspksdomains_AS857_RS04515_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982593.1"
                     /locus_tag="AS857_RS04515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_173864728.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.7e-19, bitscore:
                     64.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.5e-22,
                     bitscore: 74.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.1e-17, bitscore:
                     58.8, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTELNDTTDWAGRSVLVTGAEGFIGSTLVDLLVERGARVRVLVH
                     YKPYAERGHLARYLGPGSPVETLAGDVRDAGRVMDAVAGCDTVFHLAALIGIPYSYASP
                     EAYVQTNVAGTENVAAACRRHGVRRMVHTSTSEVYGTALTAPISEEHPLQPQSPYSASK
                     IGADMLALSYAHSFELPVTVVRPFNTYGPRQSARAVIPTILAQLHSGAEEIRLGSTSPT
                     RDFTYVTDTAEGFLALADCDRAVGHAVNLGTGREISIGDLAESLVRASGRDAKVVVDPS
                     RLRPAGSEVERLLSDNTRAREWAGWQPRVGLEEGLARTSDWVRDNLHLFAPDRYQV"
     aSDomain        complement(7536..8057)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS04515_NAD_binding_4.1"
                     /evalue="1.40E-18"
                     /label="AS857_RS04515_NAD_binding_4.1"
                     /locus_tag="AS857_RS04515"
                     /protein_end="191"
                     /protein_start="17"
                     /score="58.8"
                     /tool="antismash"
                     /translation="VTGAEGFIGSTLVDLLVERGARVRVLVHYKPYAERGHLARYLGPG
                     SPVETLAGDVRDAGRVMDAVAGCDTVFHLAALIGIPYSYASPEAYVQTNVAGTENVAAA
                     CRRHGVRRMVHTSTSEVYGTALTAPISEEHPLQPQSPYSASKIGADMLALSYAHSFELP
                     VTVVRPFNTYG"
     CDS_motif       complement(7992..8066)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AS857_RS04515_0001"
                     /evalue="1.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AS857_RS04515"
                     /protein_end="39"
                     /protein_start="14"
                     /score="14.6"
                     /tool="antismash"
                     /translation="SVLVTGAEGFIGSTLVDLLVERGAR"
     gene            complement(8126..9322)
                     /locus_tag="AS857_RS04520"
     CDS             complement(8126..9322)
                     /EC_number="2.4.1.227"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0051991 -
                     UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-
                     glutamyl-meso-2,
                     6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol
                     4-beta-N-acetylglucosaminlytransferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0007049 - cell cycle [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0030259 - lipid glycosylation [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128652.1"
                     /locus_tag="AS857_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="WP_058041786.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 1.4e-26,
                     bitscore: 88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 2.3e-32,
                     bitscore: 107.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATADDNLSVVIGAGGTGGHIYPGLAVADALRRAVPHAVISFIGT
                     ERGLETRLIPDAGYRLHTVDMIPFDSSLGARRYLLPADLLRSGRQAQRVIEEQGAHVVV
                     GMGGYPSAPAVLGARMARRPVLVHESNAVPGRANRFAATLTPHIALAFDRTREHLPART
                     ALRAETVGMPLVSDVAGLDRGGRKALRGEARRWFGVPEGTRLVLFNGGSLGAARLTEAA
                     LQLASRWRGRPDVHLVIKTGPGALEQVRARLAAEGGDRVATAVGYLDRMDLAYAAADVM
                     VCRAGSATVAELSSVGVPAVLVPYPHAPHDHQTHNARVLSDAGAGLLLPDGEATGDRLA
                     GLIEPLFADPARLAAMGTAATPGTHALAADLMAAWALRLAGRAPANPFPFQAVERNHA"
     misc_feature    complement(9345..9362)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.84"
                     /tool="antismash"
     gene            complement(9380..9928)
                     /locus_tag="AS857_RS04525"
     CDS             complement(9380..9928)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512075.1"
                     /locus_tag="AS857_RS04525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_058041787.1"
                     /transl_table=11
                     /translation="MTTFLTTARLALRPFADTEADLDLVVGLDGDPEVMRYITGGRPMT
                     RAEIRAESFERMLRGGFWATHLRDTGEFIGWHCLRPLENAPAGSADLGYRLRRAAWGRG
                     YATEGALALIDKGFGELGYDRITANTMFVNAGSRHVMEKCGLSHSRTYVEDWPYPVEGD
                     EHGDVEYVLTREEWSARRR"
     gene            complement(10001..11083)
                     /locus_tag="AS857_RS04530"
     CDS             complement(10001..11083)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959586.1"
                     /locus_tag="AS857_RS04530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_058041788.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.5e-38, bitscore:
                     127.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKSTAAAAQQRVAGYRHRFDTRFEAYFDSLAKSLDTPPLSRFTP
                     RCLELLRDLSLRGGKRLRVALLYEAARLVTDEQVPGLEEAALSIELLQTHGLVHDDIID
                     DSPVRRGGPSTYYAYRREFPGDDGTALGLAVLAGDLASFLSMHVLLGADAPAERKQAML
                     EVQLRAGAETVAGQIADLERDFQPLPSEDLLHTVCEYKTTRYSILAPLRLGLLAAGEHL
                     AEHDERLRRYATPAGISGQMRDDYLDFFGDENVIGKSPGSDIRSGRRSYAVRAVLAAAT
                     AAERSLLESALGDPGCTAETIDRIRRIAREHGVDDALRAAMLRHAEEAAGEASGWRAHW
                     REEAVAFFEGLPLWNVQRAR"
     gene            complement(11129..12118)
                     /locus_tag="AS857_RS04535"
     CDS             complement(11129..12118)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127517.1"
                     /locus_tag="AS857_RS04535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_058042099.1"
                     /transl_table=11
                     /translation="MGFGGAALGGLFRPVGAATAEGAVRAAWEAGVRYFDTAPHYGAGL
                     SEERLGAALAGVPRDAFTISTKVGRVLADADPNAGVPQGGDGGEFAVGRDRARVRDYSR
                     GGVLRSLEGSLHRLRVDRVDVLYVHDPDDHWEQAAGEAFPALARLRDEGVVKAIGIAMN
                     DAAMLTRFVAETDPDVVLCAGRCSLLDGGAQRELFPLCERRGVAVVAAGVFNSGILADP
                     RPGAYYDYRRAPERSVARAQRIAAVCETHGVPLPAAALAWPARHPAVASVLVGMRSAAE
                     VTTDVRLAGTEVPEELWRDLAAAGLLPGGPANAHGPGLHRRSGAGPMR"
     gene            complement(12202..13668)
                     /locus_tag="AS857_RS04540"
     CDS             complement(12202..13668)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00879.1"
                     /locus_tag="AS857_RS04540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_063804155.1"
                     /transl_table=11
                     /translation="MTEAQPASRTDDHADGRAGGQVGEKAPRLVHFVAVLGGLSGILYG
                     YDAGAISGALKPLTERFGLDSTEQGLVTGLMLLGALPAIVGGALAARRWDRRHLLILAG
                     AVFVAGSVGCGVAQDVVVLMVSRFVLGFAVGLANMFGLIYLSELAPGRLRGRITALYQL
                     SVNVGILLAYAVGDALSAAGAWEWMLGLGALPAVVFLAGMLVSPPGPRWLMLRGREAEA
                     RRVLRRLRATVRSADEEVAEIRAGLAGRHAGLRELLGGYRPALGITLVLTFFQVFTGIN
                     AVVYYAPVIFSHVAGGGSAGAGTVANYCVGTALVLSTAVSLPFVERLGRVRMLTVSLAA
                     QAPPMVVLAVFPDVGPLAVACVFVYTLAFGFGLGPVFWLYCPEVLPLRARAVGMGVVTF
                     AQYLLNFVFSLVFPDVLEAVGSSVFAVFAVLSVVAAWYVARWVPETAGRSLEEIERYWR
                     QRGAGGGRGEDGKRGGRGECGECEDRAGAR"
     gene            complement(13862..14479)
                     /locus_tag="AS857_RS04545"
     CDS             complement(13862..14479)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS04545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216823940.1"
                     /transl_table=11
                     /translation="MSALPSETPLSVVRPPEPTRTLTSGARHARPLSLYDSWWTVAGAA
                     LVLCAAWAACVWISFHLTADATLHTAALFVHLASLVLGFGAVLVADYYGLLWITGRCSL
                     QEALGSAGRLHLPIWAGLVGLVLSGMLLHPSPSSTLTAVKLVLVLLLGLNGLQAGLLNK
                     RMAEQSSASPAPRLLAWGGATALVSQICWWGAVVIGFLNSQS"
     gene            complement(14849..17227)
                     /locus_tag="AS857_RS04550"
     CDS             complement(14849..17227)
                     /EC_number="3.4.24.3"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057183.1"
                     /locus_tag="AS857_RS04550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="collagenase"
                     /protein_id="WP_058041789.1"
                     /transl_table=11
                     /translation="MTHSRSLRRSLRASLLTTAIATALCATAVQPAHADSPSPAAKPSS
                     ATSAPPPAAGVRQDTPTPNPFDEVTRLANAPEPAAASPTAPGGLTNGRVPGALTAKPKP
                     TAVPPRATLGGTAVPCTLDGITRLAPEQFADFLADRAVTADGCLRTLIWTWDQRLVPVM
                     SRPHVQAVSRRIESLAAAHDGKNNSHLLEMFTYLHAVAYHDFSRSEIDLTDAPTVEAIR
                     RAVSAFGTASRTFDATRTNAETLREALYAASSPGLRQHQLPLVQRVLATMDAAHSATNK
                     DTSWAGAALAALSLNYLGVYPGNHDTAFHAAVTADASYRAAFKAFAGHTHLKGTSNAWV
                     VRDGVGEYGRMGQIDALRGRITSDLGGLLSTTTGNFGEGSEPWAKVVTWLIEFDACKQY
                     GVCKADIERRIFPSTYTYDNGAIKVRTALPRATVDRLYYASKQVKAQFHRVLGTEQPLA
                     GDTNTTLNIVLYASRADYEVYHPLLTGMGTNNGGIYIENGATFYTYERRVPQDSTLTLE
                     ELFRHEYTHYLNGRWAVPGSFGEGPWYQGDRTTAMDEGTAEFFDGATRGEGIKVRKSLV
                     QSIINDTAGGTKPRMSVYELLHAEYDRDGFRFYSYAGTFFEFLWAERPSLLKEMYGHLR
                     ANDVAGFDAWRDRLGRDTGLQRAYDTFLDQQIAKVKDLYVPNTSFTPVGGLDAGHPATV
                     RASFKATTGITPECRTNEAPERPRFTCTGRITANLSSPGSPDLVFKDMSGTVDYFILDR
                     TKKGTNNFADMNCSFGKVDLWSDRPAGTADFTCEGPLRG"
     misc_feature    17398..17414
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    complement(17406..17422)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.4"
                     /tool="antismash"
     gene            complement(17437..18423)
                     /locus_tag="AS857_RS04555"
     CDS             complement(17437..18423)
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139759.1"
                     /locus_tag="AS857_RS04555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oligopeptide/dipeptide ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_058041790.1"
                     /transl_table=11
                     /translation="MTAGTAPLLSVRNVTMTFPGKRGRAAPVRAVDGVSFDLAAGETLG
                     LVGESGCGKSTTGRMIVRLLEPTTGSITYDGRDISRLGRRELKPLRKDLQMVFQDPHSS
                     LNPRQTVARIIADPLLIQGVPAAGARKRAAELMELVGLIPEHIDRYPHEFSGGQAQRIG
                     IARALATGPRLIVADEPVSALDVSVQAQIVNLMERLQRELGLAYLFIAHDLSVVKRVCD
                     RVAVMYLGRIVEVGDKERVYAAPAHPYTQALLSAVPLPDPAAERTRERITLLGDPPSPA
                     APPPGCTFHPRCPMAQEICRTEAPLLRVAAPGEAREVACHFALAHNP"
     gene            complement(18420..19454)
                     /locus_tag="AS857_RS04560"
     CDS             complement(18420..19454)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891265.1"
                     /locus_tag="AS857_RS04560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058041791.1"
                     /transl_table=11
                     /translation="MAVPAVSQEQPLLSVTDLTVTFPTRHGDVRAVDSLSFAVRRGQTL
                     GIVGESGSGKSVTSLAVMGLHTGARVTGSIALDGRELTGLPERELNRLRGRRMAMIFQD
                     PLSSLHPFYTVGEQIAEHHRVHFGSRRAAARRRAVEMLAEVGIPEPARRAGEHPHRFSG
                     GMRQRVMIAMALACEPDLLIADEPTTALDVTVQAQILELIARLQEERGLAVVMITHDLG
                     VVARVAREVLVMYGGRAAEQAPVDTLFTDPGHPYTRGLLDSLPRLDDADDAPLRAIPGS
                     PPSLLDPAPGCAFAPRCPRAAAAAPGERERCAGTRPGLRPSRGHLVSCHLSLHTAAHAP
                     GGTR"
     gene            complement(19454..20440)
                     /locus_tag="AS857_RS04565"
     CDS             complement(19454..20440)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237880.1"
                     /locus_tag="AS857_RS04565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_058041792.1"
                     /transl_table=11
                     /translation="MTLYLGRRLLAVAGVLVAIAAVTFTVFYVLPSDPAAAACGKSCST
                     DRLEAIRAHMGLDRPLWRQFADFVTGIFTGRTMGSGRYALHCAFPCLGYSYENSEAVWD
                     LLTDRLPVSASLALGAAVLWLALGLSAGVTAALRKDTLTDRALMVGAVAAASLPVYFTS
                     MMLIYGLIRTAGLLPYPQYVPLGDDPLRWASNLLLPWLALAVLYAAMYARQSRSSMIET
                     MAEPYIRTARAKGLPRRTVVVKHGLRAGMTPILTLFGMDLGGLLAGAVITESIFGLPGI
                     GRLFYGALSTGDQPVILGVTLMAAAFIVVANLAVDLLYAVVDPRVRY"
     cand_cluster    19738..32870
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    19738..32870
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[24737:27870](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      24738..27870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="2"
     gene            complement(20437..21384)
                     /locus_tag="AS857_RS04570"
     CDS             complement(20437..21384)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237881.1"
                     /locus_tag="AS857_RS04570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_058041793.1"
                     /transl_table=11
                     /translation="MTTTANTAPPAPAAVPAGSGPWQLARAELRRRTAVKVSLVVVALF
                     LLMAAGAPLLSSLAGWSPEEFDKTAVDPYLGGRPLGPLGGISADHWLGVEPVTGRDLFA
                     RVVHGAQVSLLIALTATAIVVLAGTAAGITAGYFGGRTDAVLSRLMDLTMSFPSLIFMI
                     AMMSVAKDVNRILLMTAVIGLFGWPGVARVVRGQTLSLRHREYVDAARVGGSGPWRILT
                     RDILPGVAGPVIAYTTLIVPGMIATEAALSYLGVGVRPPTPSWGQMIAESVGFYDTDPM
                     YFVIPSTCLFLTVLAFTLLGDALRDVLDPRSGRT"
     gene            complement(21398..23143)
                     /locus_tag="AS857_RS04575"
     CDS             complement(21398..23143)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378669.1"
                     /locus_tag="AS857_RS04575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_079110060.1"
                     /transl_table=11
                     /translation="MNKRTCTAMAAMLAASLALGTAGCSGGKRSAGGKDGGRNPAAHEG
                     KAIGGTPQKGGTLTVLSNQDFTHLDPARNWVMNDMDFGTRLLYRTLVTYKASPGAQGGE
                     LVPDLATDLGSPSADARTWTFHLKPGVKYEDGSPVTAQDVKYNVERSFSPDLPGGADYA
                     ARYLVGAEGYRGPAQGKHLDSIRTPDDRTIVFELRKPFAEFPNATVMPTFAPVPQAQDK
                     GPQYDNRPFSSGPYKVDSYARGKKLVLVRNEHWDPATDEVRKAYPDKLVVMMGLKANQI
                     DDRLIASQGADASAVSWGALRPESAAKVLPDAGVRERLLAESTNCTDMVQMHTGRAPFD
                     NAKVRQAVQYALDRDAVLTSSGGPAFNDLSTAYMPATLFGGKQPDTLKIPATGDTEKAE
                     QLLKEAGKPDGFSTKITASVGDKGRAEAIQQALARAGIKVTIETVDPSAFYATIGDTGN
                     RTDMVYTGWCPDYPSGSTFLPFVFDGRFIKEKGNSGNHSLFRDDATMKRMDAIAAMTDA
                     KEAAGAWQQLDGRILAQAPAVPVLVRRWPLVLGTNIAGAYGHTSFGGQIDYATVGLKDP
                     AKSRD"
     misc_feature    23182..23192
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(23206..23222)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.29"
                     /tool="antismash"
     misc_feature    complement(23208..23218)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            23271..24641
                     /locus_tag="AS857_RS04580"
     CDS             23271..24641
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452313.1"
                     /locus_tag="AS857_RS04580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_058041795.1"
                     /transl_table=11
                     /translation="MQEPAVAAIRTVSHDLPVSAEFEAFMANGWAATPLPADIRLPVAD
                     LAAARRAKLSARFPGERLIVPAGEFKVRSNDCDYRFRPHSAYAWLTGLTGEDQAGHVLV
                     LEPDGPHWHEAVLYVRPRSPRAGAEFYRDRRYGEFWVGRRPDLAEAERMTGIRCAHRED
                     YDRLPPGRDASGDDELAAALSELRLVKDAWEVEQLQLAVDHTAAGFEDVVRALPRALAH
                     PRGERWIEGVFGLRARAEGNGPGYETIAASGAHACVLHWIRNDGRLDPRELLLLDAGVE
                     TDTLYTSDITRTLPLSGCFSPVQRQVYELVLAAQDAGMAALKPGASFRDFHRAGMRVIA
                     EGLAEWGVLKSAEGDFHRRYTLCSSGHMLGLDVHDCAQARADAYLDGVLEEGQVLTVEP
                     GLYLQPDDETLPAELRGIGVRIEDDLVITADGARLMSHALPRTPDAVEAWMGELLEG"
     misc_feature    24710..24720
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    24713..24728
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.3"
                     /tool="antismash"
     gene            24738..25883
                     /locus_tag="AS857_RS04585"
     CDS             24738..25883
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642316.1"
                     /locus_tag="AS857_RS04585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_058041796.1"
                     /sec_met_domain="DAO (E-value: 1.9e-66, bitscore: 220.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNSSSDVIVVGAGVVGAACAYYAARSGLSVTVVDRGPVAGGTTG
                     AGEGNLLVSDKEPGPELELALLSTRLWHELAQELPARIEYEAKGGLVVASDAAAMAALR
                     KFAAAQAGAGVTAEEIPADRLHDVEPHLAPGLGGGFRYPQDAQVQPALAAAHLLRASGA
                     RVRTGEEVTAVLTGADGEVRGVRTAAGELHAPFVVNAAGTWGGEVARLAGGHLPVLPRR
                     GFVLVTEPLPRVVRHKVYAADYVADVASGSAELQTSAVVEGTPAGPVLIGASRERVGFD
                     RTLSVEVLRRLAAQATALFPVLAGVRALRTYAGFRPYLPDHLPAIGPDPRVPGLLHACG
                     HEGAGIGLAPATGLAVARQLTGGEPPLDLGPFRPGRFAPAA"
     gene            25971..26285
                     /locus_tag="AS857_RS04590"
     CDS             25971..26285
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237883.1"
                     /locus_tag="AS857_RS04590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_058041797.1"
                     /sec_met_domain="Fer2_4 (E-value: 6.1e-28, bitscore: 92.5,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARTPADLVRAEPDPPFEITFDGRTVTALPGQSVAAALWAAGILA
                     WRTTRYGGRPRGAFCGIGQCYDCLATVNGEPNRRACLVPARPGDAITTQEGHGRAGLAV
                     "
     gene            26266..27870
                     /locus_tag="AS857_RS04595"
     CDS             26266..27870
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543027.1"
                     /locus_tag="AS857_RS04595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_058041798.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.9e-21, bitscore:
                     72.3, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 4.3e-12, bitscore:
                     42.0, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGSPSEPYDLAVIGAGPAGLAGAATAARLGLSVAVLDAAAQVGG
                     QYFRHPAPGLGAAHPQALHHDWAAFTELRGRFEVSGAAHLAGHHVWAVTRRDEEVWSVH
                     ALVGEEGGANAGRAGGAASGSGGAGAAVSGTGSDDVSGTRSSGTGRSCEGRTEASFSGE
                     RERPVRLHARAVLFATGAGERQLPFPGWTLPGVVGAGGAQAMLKSGLVLPGQRIVVAGS
                     GPLLLAVASSLAAAGARVPAVAEASGYLGYARRPGALAANPHKLLEAAVHGTALVRHRI
                     PLHTRSAVTEVHGTDRVEAVTVSRLDRDWRPVPGTGRRIACDALAVGHGLAPQTELATG
                     LGCETRRTPDGTHALVLDGLQETSVPGLWAAGEAGGTGGWQLARVEGELAGIAVAARLR
                     ALPALTRSRRVRDLARRRDRMRAFADAMAAAHAPGPGWTAWLDDDTDVCRCEEVTAGSI
                     REAVTEFGARDARTVKLLTRAGMGWCQGRMCGAAVACLAASGTAQGTVPPSAERRPLAV
                     PVPLGSLAAGPEEPGDA"
     gene            27935..28843
                     /locus_tag="AS857_RS04600"
     CDS             27935..28843
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091456.1"
                     /locus_tag="AS857_RS04600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_058041799.1"
                     /transl_table=11
                     /translation="MTASSWTPDRPWRGIMVATTLPLRPDLSVDYDAYAEHVRRLVENG
                     CDGVVPNGSLGEYQTLTPQERARVVRTAVEAAGDGARVMPGVAAYGSAEARHWAEQAAE
                     AGCGSVLLLPPNAYRAGEQAVRAHYTEVAAAGIPVVAYNNPIDTKVDLTPALLARLHAD
                     GSIVAVKEFTGDVRRAYEIAELAPELDLLIGADDVLLELATAGAVGWIAGYPNAFPATC
                     AALYRAAVAGDLQTALPLYRSLHPLLRWDSKTEFVQAIKLSMDITGHHGGPTRPPRLPL
                     TGETEAAVRAATEKAVADGHH"
     gene            28904..29908
                     /locus_tag="AS857_RS04605"
     CDS             28904..29908
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891275.1"
                     /locus_tag="AS857_RS04605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline racemase family protein"
                     /protein_id="WP_058041800.1"
                     /transl_table=11
                     /translation="MRTRHVFHAVDSHTEGMPTRVITGGVGVIPGATMAERRLHFIEHM
                     DHLRTLLMYEPRGHASMSGAILQPPTRPDADYGVLYIEVSGVLPMCGHGTIGVATVLVE
                     TGMVPVSEPVTTVRLDTPSGLITVDVQVEDGAAKSVTLVNVPSFSVGLDRKADVPGHGT
                     VTYDLAFGGNFYAFVELDALGLPFDRARKDDLLAAGLAVMEAVNASPDRPVHPEHPEIN
                     GLKHVYLAAPGSDARHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGALPLDRDFVNE
                     SFIGTRFTGRLVGETQVGGVPAVVPAITGRAWITGTAQYFLDPDDPFPGGFLL"
     gene            29905..31275
                     /locus_tag="AS857_RS04610"
     CDS             29905..31275
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091454.1"
                     /locus_tag="AS857_RS04610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_058041801.1"
                     /sec_met_domain="Aldedh (E-value: 4e-125, bitscore: 413.6,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPTSFASHNPADPSDVVCDVPASGASGAAEAVEQARAAQPGW
                     LQAGAAARSSALSAVAAAVEAAAGELAALAVREVGKPLAEARAEVARTAAIWRYYAQAP
                     YEPTGAVHETAGGPGLLLTRRRPHGVAGLITPWNFPFAIPSWKAAPALAAGNTVVLKPA
                     PEATACALRLAELVRQALPAAVFTVVPGGATEGNAVLATADAVSFTGSTAVGAVVTRAA
                     TARGIPVQAETGGLNAAIVLPDADIGRAAAHIAAAVAGYAGQKCTATSRVIAVGAALDP
                     LREALAEALRALPVGDPADPATVCGPLISARARGRFDQALSGASVLAAGTAPEGPGWYA
                     APTVAEKVPAGHRLLTEEVFAPVAALLPADDLPHAVRISNSVPYGLVTSVHTGGLEAAL
                     HGLDGLDTGMIRVNAPSTGVDFHLPFGGTKASGHGPREQGRAALEFYTSSRTYTLAP"
     misc_feature    complement(31281..31297)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    complement(31283..31293)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            31406..32086
                     /locus_tag="AS857_RS04615"
     CDS             31406..32086
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309271.1"
                     /locus_tag="AS857_RS04615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_058041802.1"
                     /transl_table=11
                     /translation="MGHLKQRTLITATERLRDQVAHALRAALISGELHPGEVYSAPQLA
                     EDFGISATPVREAMLDLAREGLVEPVRNKGFRVTEVNERDLDQYTEIRTLIEVPTTGRV
                     TRTAAREDLEALRPVAEEIVRAARDHDLIGYLEADRQFHLTLLALSGNERLVETVGDLR
                     KRSRLYGLTALDRRGELIPSAEEHLELLDLMLAGDAEGAEQCMARHLGHVRSLWAKGSS
                     DKDS"
ORIGIN
        1 ggcgcccggt ggaggcgcag tagccggcca cggcgtccac ggcgtcggcg aggaggaccc
       61 ggtacgggac cggctgctcg tcgcgccaca ggagccggtc gacgagggcg gtcagcagga
      121 tccccaccgt gagcccgccg agccgctcgc ccagcgaccc ggggtcgtac ggcgggaagc
      181 acgggagcag gtagtacagc tggaaggcgg aggccagccc gcccaggcgc ggcccgccga
      241 cccccaggta cgaggccgtg aagcccacca cgaacatgcc gcaggcggcg ctccacgagt
      301 gcgccgcgag cagcgtgccg gcggtgacca ggacccagcc ggcgggcagc accgcgagga
      361 acgtccgagt ccgctgctcc gcgggccccg ggacctggga gaacaacgtc agcggcagcg
      421 cgccgaacag ggcgtagagg gccatgccgg gcgcgccgaa gccgtagcgc agggtgtaga
      481 agccggtgag cccggcgacg gcggcccagg tcgcacgccg gaggtgctcc ggcccctgct
      541 cctgccgcag cagccaccgg agcgggccgg tcacctccac gacggctccc ggccggcggg
      601 gggacgcgtc acgcttgtca ccctaggcga accgcgcacc ttcgcaaccg ggaccgaccc
      661 ttcgcgacgg cgttccgcct ccctttcgtg acggcgttcc gcctcggttc tccaccgtca
      721 gttctccacg gtctggaccc gcggcggatg gccgttccac gtgacgaaca ccgacgtcgt
      781 cttcgtgccg gccatgaagt ccacccggat ccaggcgctc tgcttccaca cccgcatctg
      841 ccacccctcc tccggcgtcg ccgagacgag cgtggcggag ctctcgccga ggtcgaagac
      901 cgcccggccg ccccggaccg gatagctctt cacttcgccc gcgcccggct gggcttgggc
      961 ctcggggctc tgcgccgacc cggacgcggc tccggacccg ggcgcagacg tgtccggggc
     1021 cgggggcgcg agttgcttcc cggaggggga cgcggtgccc ggtggtgagg gggagggcag
     1081 cgggcccggt gtacgggtcg aggaggccgg ttcgcctatg gccggtgccg ctgtgccgga
     1141 gatcggcagc gcgcgcggcg gctcgtaggc cgtgcccgcc agcacggtgc gcaccccgta
     1201 ccaggacacc gccatggcgg ccgcggtcgc cagcatccac gccagggcct gcatgattcc
     1261 tcgtctcacc tggctcatag tgcctcaccc gtatggcgta cggtgcgggc catggcaaga
     1321 ctgctcgtgg tcgaggacga cccgttcgtg cgttccgccc tcatccggca gctcaccgag
     1381 gcttcgcaca ccgtgcgcag tgtcgggacc gctctcgagg cgttgcgcga ggtggcgcag
     1441 gtcggcttcg acctggtcat cctcgacctg gggctgccgg atctcgacgg ggcgcaggcg
     1501 ctcaagatgc tgcgcggcat taccgacgta ccggtcatcg tggccaccgc ccgggacgac
     1561 gaggccgaga tcatccggct gctcaccgac ggcgccgacg actacctggt caagccgttc
     1621 tccgtggcgc acctgaccgc acgcatggcc gccgtgctgc gccgttcggg ccggggcggg
     1681 ccggcgggcg agcccgcgcc gtccgccgcg cttcaggtcg gcggcctgtc ggtcgacccc
     1741 ttgcgccggc tggcggaact ggacggcgcc ccactggacc tgacgcgccg tgaattcgac
     1801 ctgctcgcct acctggccgg ccgcccgggc gtcgtcgtcc cgcgcaagga gctcctcgcc
     1861 gaggtctggc agcagtccta cggggacgac cagaccatcg acgtgcacct ctcttggttg
     1921 cgccgcaagc tcggcgagac cgccgccagc ccgcgctacc tgcacaccgt ccgcggggtc
     1981 ggggtgaagc tggagccccc ggcggcgggg acggcgctcc cggagcagcc gtgagatggg
     2041 cgctcgtcag ggtttcgctg gccgtcacgg tgatggtcgt gctggccttc gccgtgccgc
     2101 tcggcctggt ggtcaaggaa ctggcccggg accgggcctt cgccgatgcc gaacggcagg
     2161 ccgcccagat ccggcccgcg ctcgccatca ccaccgaccg cgaccagctg gaacgggcgg
     2221 tcgccagctc acaggccggc ggggacggac ggatggccgt ccacgtaccc ggtaacgacg
     2281 acaagcagaa cggcgacaag cagaacgacg acacacagca aggcgcgggc gccgaagggc
     2341 acaaggcgta cgacatcggc ccgcgccggg ccgacccgcg ggacgtggag accgcccgcc
     2401 gcggccgctc cgccgtcacc tccgtgcccg gtggctacgc cctgctgcag ccgacggccc
     2461 tgagcaccgg cgagttcgcg gtggtcgagg tgtacgtgcc gcatcgcgcc gtcggcaacg
     2521 gagtcaccac ctcctgggcg atcctcgccg gcgtgggcct cggcctgatc gccggttccc
     2581 tcgtcaccgc ggaccgcctc ggcctgcgcc tggtacgccc ggcggagcgg ctcgcgaagg
     2641 cggccgccga gctgggggag ggcaagctgg gcgtccgggt acgcgaggac gggccggcgg
     2701 aactgcgggc cgcggccgtc gcgttcaact ccatggccga caagatcgtg cagctgctct
     2761 ccaacgaacg cgagctcgcc gccgacctct cccaccgcct gcgcaccccg ctcaccgtcc
     2821 tgcgcctgaa cgccgcgtcg ctcggcgagg gcccggccgc cgagcagacc cgcgccgccg
     2881 tggcccagct ggagcgcgag gtcgatcagc tgatccgtgc ggcccgcgag cagggcgagc
     2941 agaaggaacg gcccacgctc ggctgcgacg ccagcgaagt gatccgcgac cggatggact
     3001 tctggtccgc gctcgccgag gacgagggcc gcacggtccg gctctcgggt gtcgacgcga
     3061 ccgtacgcgt ccccgtcgcc cgccccgaac tcgccgccgc actggacgcg atgctcggca
     3121 acgtcttccg gcacacaccc gagggcactg ccttcgcggt cgacgtgcac cacagcgacg
     3181 acgccgtcat cgtcctcgtc tccgacgcgg gcccgggcat cgccgacccg gacgccgcac
     3241 tgcgccgcgg ccacggcgcc ggcggccccg gttccaccgg cctcggcctg gacatcgtgc
     3301 gccgcgtcgc ggagtcgacg ggcggcgacg tacggatcgg gcggtcggtg ctgggcggca
     3361 cggaggtgcg ggtgtggctc tcgccggacg gcggcggatc caagggccgt gagcgccgcc
     3421 gccggcgggt acggcgcggc cggtcgcgcc gttgaccccg acgccgcacc cgtggccggc
     3481 acccctcatt aacccccgcc gatgcgttcc ttaacgcagc cataaggagc gggcccggga
     3541 agccgattcg acgatttgcc tgttttggtc tcgctagcgt gccgcacgta cccacccccc
     3601 aaccccaccc cccaacccag aacaggcagg cacgcgatgg gttcctccgc acaccgccga
     3661 cgagtgagcc gcaaggcgaa gctcgccggc gcaggcctcg ccgcggcgat cgcgacgggc
     3721 gccgcgttca ccctcaccgg cacggcgcag gccgcctcgg tcggcgcggc cttctcccgg
     3781 accggcgcct ggtcggacgg ctacaccggg cagtacgtcc tcaccaacga cacgggcaag
     3841 gacctgtcgg gctggaagct caccttcgac ctcccggccg gcgcgaagat cacctcgctg
     3901 tggaacggca agcacaccgt cagcggccgc agcgtcaccg tcgagccgga gagctggaac
     3961 gcgacgatcg cccccggcaa gtctgtgacc gtcggcttcg tcgccgccgg cagcggggtc
     4021 ggcgccggcg cggccgacgc cccggccaac tgccggatca acggcacgaa gtgttccgtg
     4081 gacaaggacc ccggcccgca gccctcgggg tccacggggg ccacgggttc caccaagccc
     4141 accgatccca ccacccccac gtccgccccg ccccagccgc aaccgcagcc gaccgtgacc
     4201 tccccggccc ccggcggcgc gaacgcggcc ttcgccccgt acgtcgacac ctccctccac
     4261 cccacctacg acctcctgga caccgccaag aagaccggcg tcaagaactt caacctcgcc
     4321 ttcgtcacct ccgggggcgg ctgcacgccc aagtggggcg gtgtcaccgg catcgggagc
     4381 gaccccgtgg cgcagcagat cgggaagctg cgcgcggcgg gcggcgacgt acgggtctcc
     4441 ttcggcggcg ccgccggttc cgaactgggg ctcgtctgct cctccgcgga cgaactcgcc
     4501 gccgcgtacg gcaaggtcgt cgacgcctac aagctcacca aggtggactt cgacatcgag
     4561 ggcgcggccc tgcccaacgc cgccgccaac acccggcgcg cccaggcgat cgcctcgctc
     4621 cagaagaagc accccggcct cgacgtctcc ttcaccctcc cggtcatgcc caccgggctc
     4681 acccaggagg gcgtcgacct ggtcgggaac gcgaagaaga gcggcgtctc cgtctccgcg
     4741 gtcaacatca tggcgatgga ctacgggtcg tccttcaacg gcgacatggg gcagtacgcg
     4801 atcgacgccg ccaccgcgac gcaggcgcag gtcaagggcg tgctggggct gagcgacaag
     4861 gccgcgtgga aggccgtggc ggtcaccccg atgatcggtg tcaacgacgt ggccgccgag
     4921 gtcttcaagg tcgacgacgc ggcgcagctg gccgcgttcg gccggtccaa ggggatcggc
     4981 tggctgtcga tgtggtccgc cgcgcgcgac aagcagtgcc cgggcggtgc gcagaactcc
     5041 gcatccgcga cctgcagctc gatcgtccag gacgaactcg ccttcaccaa ggcgttcgcg
     5101 gcccgcaagg gctgacgcgc ttcccgttcc ccgtccccca accccccacg tagaagcccc
     5161 ccacatcccc ccacaccgcc ccgcacgtcc ggcacccccc acctcacggc cggcgtgcgg
     5221 ggccaccccc tcacccacaa ggagaccctc atgcgcacgc gtcacaaggc cgtacggatg
     5281 actctgctcg gcgccgcccc tctcgcgctc accgcgctga ccgccgtacc ggccgaggca
     5341 cacggctcca tgacggaccc ggtcagccgg gtgtccgcct gtttcgccga ggggccggag
     5401 caccctcgtt cggccgcctg caaggcgatg gtcgcagcgg gcggcaccca gcccctctac
     5461 gactggaacg aggtcaacat cggcgatgcc gccgggcgcc accgccagat catcccggac
     5521 ggcaagctgt gcagcgcggg ccgcgccaag tacaaggggc tggacctgcc gcgcgccgac
     5581 tggcccggct cgaagctggc gcccggcaag cacaccttcc ggtaccgggc gaccgcaccg
     5641 caccgcggca cgttcgagct gtacctcacg aaggacggct acgacccgaa gaagccgctg
     5701 aagtggtccg acctggaggc caagccgttc gccaaggtca ccaaccccac gctgaaggac
     5761 gggagctacg tcttcgacgg caccgtcccg aagcggtccg gccgccacct cgtgtacagc
     5821 gtctggcagc gctccgacag ccctgaggcc ttctacacct gctcggacgt ggacttcggc
     5881 gggaagggga aggcggcgac ggcggcgcag gccgcagccc cggccgcgtc cgctcccagc
     5941 gaccggcaga taacagagga ggccgcgaaa tcgaccgtcg accacggcgg gcacggcggt
     6001 gacggccccg gcgacagcgg ccacggcgcg ggaggtaacg gcgggaacgg gcatgcggag
     6061 aagagccacg gtgagaacgg ccgggccggt tccgacggaa aggccggcgc cggagacgtc
     6121 ggtgccggaa acgagccccg gtccgcggtg aaggcggcca acgccccggc cgcccagggc
     6181 gggcgtctag cggagaccgg tggtgacgac cgtacggcca tgctggccgt cgcgggcgcc
     6241 ggcgtcctgg cagtcggttc cgccaccttg ttcctggccg tgcggcgccg ctccgcccgc
     6301 aaccacgcct gaggcccggg ccctggtcag ccgttgcggc cggggccggt aggccggtgc
     6361 catgtgtccg tcgggccgac cggcaccacg acgggagggt ggcgccgcgg cggccgtacc
     6421 gccccgcggg cgtccttcac gtccgcctcg tcggggtgga cgaccatgac ggggccgcgg
     6481 gcgtgccgga ggcagtggcg gctgaccgag ccgtggagga accggtgcca cagcccgtgg
     6541 ctgccggcgc ccagcaccag catgtccgtg tcgtgccggg cgctggccac cagggccggt
     6601 cccggctccg cgcggacgat ccgcggggcc accctcaggc ggaacggtgc ggcgccgagc
     6661 gccctctcgc acgtcttggt cagggccctg cgggcctggg cctcccagtg cgcgcggacg
     6721 tcggccgggg cgggctgcag ggcgtccgcc gcctccccgc ccggcggcga ccaggccagc
     6781 acgggacaca gggccgcgcc gtggcgggcc gcctcctgcg cgccctgcct gagcgcggcg
     6841 acactgcccg ccgaaccgtc cacgcctacg acgacgcgct ccaccgttcg cgacataccg
     6901 tccgcctcct cgggattcgt ctgtccgctg tacggcaacg tgatccacgt tacgaagcgc
     6961 ccgcccgatg cgtatcggcc taatgggtgg caaatcgggt gataccccct ccggtcggag
     7021 ggggtgtgcg aggcctcgcc accctcctca cggatggtga cgggcccgcc actgctcgga
     7081 cccgaccgga ccgatcagac ctgatagcgg tccggggcga agaggtgcag gttgtcccgg
     7141 acccagtccg aggtgcgggc caggccctcc tccagcccca cccggggctg ccatccggcc
     7201 cactcccggg cccgggtgtt gtccgacagc agccgctcca cctcactgcc ggcgggccgc
     7261 agccgcgacg ggtccaccac gaccttcgcg tcccggccgg aagcccggac cagtgactcg
     7321 gcgaggtcgc cgatggagat ctcccgcccg gtgccgaggt tgacggcgtg ccccacggcc
     7381 cggtcgcagt ccgcgagcgc caggaagccc tcggcggtgt cggtgacgta ggtgaagtcg
     7441 cgcgtcggcg acgtggaccc cagccggatc tcctcggccc ccgagtgcag ctgcgcgagg
     7501 atcgtgggga tcaccgcccg cgccgactgc cgcggtccgt aggtgttgaa gggccgcacg
     7561 accgtcaccg gcagctcgaa ggagtgcgcg taggacaggg ccagcatgtc cgcgccgatc
     7621 ttcgaggcgg agtacggcga ctgcggctgc agcgggtgct cctcgctgat cggcgcggtc
     7681 agggcggtgc cgtagacctc gctggtcgac gtgtgcacca tgcgtcgcac accgtggcgg
     7741 cggcaggccg cggccacgtt ctccgtaccg gccacattgg tctgcacgta cgcttccggc
     7801 gacgcgtagc tgtacggaat gccgatcagg gccgccaggt ggaagacggt gtcgcacccc
     7861 gccaccgcgt ccatcacacg cccggcgtcg cggacgtccc cggcgagcgt ctccaccggc
     7921 gaaccgggcc cgaggtaacg ggcgaggtgg ccgcgctcgg cgtacggctt gtagtgcacg
     7981 agcacccgga cgcgcgcccc gcgctcgacg agcaggtcga cgagggtcga cccgatgaag
     8041 ccctcggctc cggtgaccag cacgctgcgt ccggcccagt cggtggtgtc gttcagctca
     8101 gtggtcattg cagtggtcat gccggtcatg cgtggttcct ctcaacagcc tggaacggaa
     8161 agggattcgc gggggcgcgg cctgccaggc gcagcgccca cgccgccatg aggtcggccg
     8221 cgagggcgtg cgtgcccggg gtggccgcgg tacccattgc ggcgagccgg gccgggtcgg
     8281 cgaacagggg ctcgatcagg ccggcgagcc ggtcgccggt ggcttcgccg tcggggagca
     8341 ggagccccgc gccggcgtcc gagagcaccc gggcgttgtg ggtctggtgg tcgtgcggcg
     8401 cgtgcgggta cgggaccagg accgcgggca cgcccacgct cgacagctcc gccaccgtcg
     8461 ccgatcccgc ccggcacacc atgacgtcgg cggccgcgta ggcgaggtcc atccggtcga
     8521 ggtagcccac cgcggtggcc acccggtcgc cgccctcggc ggcgaggcgg gcccgtacct
     8581 gctccagtgc gcccggcccg gtcttgatca ccaggtggac gtccggccgc ccgcgccacc
     8641 gcgaggccag ctggagcgcc gcctccgtca gccgtgccgc gcccaggctc ccgccgttga
     8701 aaagcaccag ccgcgtgccc tccggcaccc cgaaccagcg gcgggcctcc ccgcgcagag
     8761 ccttccgccc gccccggtcg agccctgcga cgtcgctgac cagcggcatg ccgaccgtct
     8821 ccgcgcgcag ggccgtacgc gccggcaagt gctcgcgggt gcggtcgaag gcgagcgcga
     8881 tgtgcggggt gagggtcgca gcgaaacggt tcgccctgcc cggcaccgca ttcgactcgt
     8941 gcaccagcac cggccggcgc gccatccgcg cccccagcac cgcgggcgcg ctcggatagc
     9001 cgcccatgcc cacgacgacg tgcgcaccct gctcctcgat cacgcgctgc gcctgtctcc
     9061 ccgagcgcaa cagatcggcg gggagcaggt accggcgggc cccgagcgag gaatcgaagg
     9121 ggatcatgtc cacggtgtgg agccggtatc ccgcatccgg tatcaggcgg gtctccagac
     9181 cgcgttccgt accgatgaaa ctgatgacgg cgtgcggcac tgctctgcgg agcgcgtcgg
     9241 cgaccgccag cccggggtaa atgtgaccac cggtcccgcc tgcgccgatg accaccgaaa
     9301 ggttgtcgtc tgctgtagcc atggccgcag cttggcgaaa cgctttaaga acccactaag
     9361 aaaaaccctc gccggcaggc tagcggcggc gggccgacca ctcctcccgg gtcaggacgt
     9421 attcgacgtc gccgtgctcg tcgccctcga ccgggtaggg ccagtcctcg acgtacgtgc
     9481 gggaatgcga gagcccgcac ttctccatga cgtggcgcga gcccgcgttc acgaacatcg
     9541 tgttcgcggt gatccggtcg tagcccagct cgccgaatcc cttgtcgatg agggcgaggg
     9601 cgccttccgt cgcgtagccg cggccccagg cggccctgcg gagccggtag ccgaggtcgg
     9661 ccgagccggc gggggcgttc tcgagggggc ggaggcagtg ccagccgatg aattcgccgg
     9721 tgtcccgcag gtgcgtcgcc cagaagccgc cgcgcagcat ccgctcgaag gactcggcgc
     9781 ggatctcggc ccgtgtcatg gggcggccgc ccgtgatgta ccgcatgacc tcggggtcgc
     9841 cgtcgagtcc gacgacgagg tccaggtcgg cctcggtgtc ggcgaacggg cgcagggcca
     9901 ggcgggcggt ggtgaggaag gtggtcatgt ggggatcttc gtcagggcgt gctgcgggcg
     9961 ccagccgatt tcccgagcga cgggttcctc aaggggttgc tcaccgggcg cgctgtacgt
    10021 tccacagcgg cagtccctcg aagaaggcca ccgcctcctc gcgccagtgc gcacgccagc
    10081 cggaggcctc cccggcggcc tcctcggcgt ggcggagcat cgcggcccgg agcgcgtcgt
    10141 ccacgccgtg ttcccgggcg atccggcgga tgcggtcgat cgtctcggcc gtgcagccgg
    10201 ggtcgccgag cgcggactcc agcaggctgc gctccgcggc cgtggcggcg gccaggaccg
    10261 cgcgcacggc gtagctgcgg cggccggagc ggatgtcgga gcccggtgac ttcccgatga
    10321 cgttctcgtc gccgaagaaa tcgaggtagt cgtcgcgcat ctgtccgctg atgccggccg
    10381 gtgtcgcgta gcggcgcagc cgctcgtcgt gctcggccag gtgctcgccg gcggccagca
    10441 gccccaggcg cagcggggcg aggatcgagt accgggtggt cttgtactcg cagacggtgt
    10501 gcagcaggtc ctcggacggc aggggctgga agtcgcgttc caggtcggcg atctggccgg
    10561 caacggtctc cgcgcccgca cgcaactgca cctccagcat ggcctgcttg cgctccgcgg
    10621 gggcgtccgc ccccagcagg acgtgcatgg acaggaagga cgcgaggtct cctgcgagca
    10681 cggcgagccc cagtgcggtg ccgtcgtccc cggggaactc ccggcggtag gcgtagtacg
    10741 tggacgggcc gccgcggcgc acgggcgagt cgtcgatgat gtcgtcgtgg accaggccgt
    10801 gcgtctggag cagttcgatg ctcagcgcgg cctcctccag gccgggcacc tgctcgtcgg
    10861 tcaccagccg ggccgcctcg tacagcaggg cgacccgcag gcgcttcccg ccgcgcaggg
    10921 agaggtcccg caggagttcc aggcagcggg gggtgaagcg gctgagcggc ggggtgtcga
    10981 ggctcttcgc gagggagtcg aagtacgcct cgaagcgggt gtcgaaccgg tgccggtagc
    11041 cggcgacccg ctgctgggcg gcggccgcgg tcgatttgtc catgggacca ccatttcagc
    11101 aggtcaggag ctcggggatg cgccttcatc atcgcatcgg cccggcaccc gaccgacggt
    11161 gaaggccggg tccgtgagcg ttggccggtc ccccggggag cagcccggcc gcggccaggt
    11221 cccgccacag ttcctccggc acctccgtgc cggccaggcg gacatccgtc gtgacctcgg
    11281 ccgcgctgcg catgccgacg agcacggagg ccaccgcggg gtgccgggcc ggccaggcca
    11341 gtgctgctgc gggcagcggt acgccgtggg tctcgcatac ggcggcgatg cgctgcgccc
    11401 gcgccaccga tcgttccggc gcccgccggt agtcgtaata ggcgcccggg cgcgggtcgg
    11461 ccaggatgcc gctgttgaac actccggccg cgacgacggc caccccgcgc cgctcgcaca
    11521 acgggaacag ctcgcgctgt gcgccgccgt cgagcaggct gcagcgtccc gcgcacagca
    11581 ccacgtccgg gtcggtctcg gcgacgaacc gggtgagcat cgcggcgtcg ttcatggcga
    11641 tcccgatcgc cttcaccacg ccctcgtcgc gcagccgggc cagcgccggg aacgcctcac
    11701 cggccgcctg ctcccagtgg tcgtcgggat cgtggacgta cagcacgtcg acccggtcca
    11761 cgcggaggcg gtgcaggctg ccctccaggc tgcgcagcac tccgccccgg ctgtagtcgc
    11821 gcacccgcgc ccggtcccgg ccgacggcga actccccgcc gtccccgccc tgcggcactc
    11881 cggcgttcgg atcggcgtcg gcgaggacgc ggccgacctt ggtggagatg gtgaacgcgt
    11941 cccgcggcac tccggccagg gccgcaccga gacgttcctc ggacaatccg gctccgtagt
    12001 gcggagcggt gtcgaagtag cggacgccgg cttcccaggc cgctcggacg gccccttccg
    12061 ccgtggccgc gccgaccggg cggaacagtc cgccgagcgc cgcgccgccg aagcccatcc
    12121 gggtgaccgg gagaccggac cggccgagcg cggcgtaccc ggccgggcca ccgggcaggg
    12181 cgagggacac cggagaggcg gtcaccgggc acccgcccgg tcctcgcatt ccccgcactc
    12241 cccacggccc ccgcgtttcc cgtcctcccc acggcctccg cccgccccgc gctgccgcca
    12301 gtaccgttcg atctcctcca gcgaccgccc cgccgtctcc ggaacccacc gggcgacgta
    12361 ccacgcggcc actacggaca gcaccgcgaa gaccgcgaac accgagctgc cgaccgcctc
    12421 cagcacgtcc gggaagacca gggagaagac gaagttgagc aggtactgcg caaaggtcac
    12481 cacgcccatg ccgaccgccc gggcccgcag cggcagcacc tcggggcagt acagccagaa
    12541 cacggggccg agaccgaacc cgaaggccag ggtgtagacg aacacgcacg ccacggcgag
    12601 cggtccgacg tccgggaaga cggccagcac caccatcggc ggcgcctgcg cggccagcga
    12661 gaccgtcagc atccgcaccc tccccagccg ctcgacgaac ggcagggaga cggctgtgga
    12721 cagcacgagc gccgtgccga cgcagtagtt cgccacggtg ccggcaccgg cgctcccgcc
    12781 gccggcgacg tgggagaaga tgaccggcgc gtagtacacc accgcgttga tcccggtgaa
    12841 gacctgaaag aacgtcagca cgagggtgat gcccagcgcc ggacggtacc cgcccagcag
    12901 ttcgcgcagg cccgcgtgcc ggccggccag acccgcgcgg atctcggcca cctcctcgtc
    12961 cgcactgcgg acggtggcgc gcaggcggcg cagcacccgg cgcgcctcgg cctcccggcc
    13021 gcgcagcatc agccagcggg gtccgggcgg gctgacgagc atcccggcca ggaagacgac
    13081 ggcggggagc gcccccagcc ccagcatcca ctcccacgcg ccggccgccg acagcgcgtc
    13141 gcccaccgcg taggcgagca ggatgccgac gttgaccgag agctggtaca acgccgtgat
    13201 ccggccccgc agtcgtccgg gggcgagctc gctcagatag atcagcccga acatgttggc
    13261 caggcccacg gcgaagccga gcacgaaccg ggagaccatc agcaccacga cgtcctgcgc
    13321 gacgccgcag cccaccgaac cggccacgaa gaccgcaccg gccaggatca gcaggtgccg
    13381 ccggtcccag cgccgcgccg ccagcgcacc gccgacgatc gccggcagcg cgccgagcag
    13441 catcaggccg gtcacgaggc cctgttcggt ggagtccagg ccgaagcgct cggtcagggg
    13501 cttcagtgcg ccggagatcg ccccggcgtc gtagccgtac aggatcccgg agagaccgcc
    13561 gagcacggcc acgaagtgca ccagccgtgg ggccttctcg cccacctggc cgccggcccg
    13621 cccatcggca tggtcgtctg tacgggacgc cggctgcgcc tcggtcacgg gccctcccag
    13681 gatcggtgaa ccggggtggc gcggcgccgg cttctccggg gaccgcccgt gatgacggag
    13741 ccgcctggtg agcgtgagca gcagccagca tgacgaccgg gccgtacggc cgcaagaccg
    13801 gcccccgcgg caccacctgc cccgcacggg ggcaggcggc tcgccggaac cggccggtgc
    13861 gctaactctg gctgttcagg aagccgatga cgacggcccc ccaccagcag atctgggaga
    13921 cgagggcggt ggcgccgccc caggccagca ggcgcggtgc gggtgacgcg gaggactgct
    13981 ccgccatgcg cttgttgagg aggcccgcct gcaggccgtt gaggccgagg aggagcacca
    14041 gcaccagttt gacggcggtg agcgtggagg acgggctggg gtggagcagc atgccgctga
    14101 ggacgagtcc cacgagaccg gcccagatgg gcaggtgcag ccggcccgcg ctgccgaggg
    14161 cctcctggag gctgcagcgg cccgtgatcc acagcagccc gtagtagtcg gcgaccagca
    14221 cggcgccgaa gccgaggacg aggctcgcga ggtggacgaa gagcgcggcg gtgtggagcg
    14281 tcgcgtcggc cgtcaggtgg aaggagatcc acacgcaggc cgcccaggcc gcgcacagca
    14341 cgagcgcggc gccggccacc gtccaccagg agtcgtacag gctcagcggc cgcgcgtggc
    14401 gggcgccgga ggtgagggtg cgggtcggtt caggcgggcg gacgacggac agcggcgtct
    14461 cggacggaag agcggacacg cggaattctc ccaacacagg ccctcgcggc agacgcggga
    14521 ccttacagcg gaaaggctta tcgatgaccg gccgtgcgtt accggcttgt tgccggaatg
    14581 agactttctc ggggaacggc cgggctcggt gcccgataaa cctgaacact ctcgggagga
    14641 aatcgcaagc tgcgcaggtc aggaagggaa tcggcggcta ttgatccgcg cgcattcccg
    14701 gccggtcggt gaattgacgg ccgcggaatg gtgatcgctt ttctttggaa tgtgtgacgc
    14761 ggcacatttc ttgggcgggt gagtgagtgc acatgggcgg gggggtttcg ggcctgcctt
    14821 ccggggcagg tccgaaaccc tcgtggaatc agcccctcag cggtccttca caggtgaagt
    14881 ccgccgttcc cgcggggcgg tccgaccaga ggtcgacctt gccgaaggaa cagttcatgt
    14941 cggcgaagtt gttggtgccc ttcttcgtgc ggtcgaggat gaagtagtcg accgtcccgg
    15001 acatgtcctt gaagaccagg tcggggctgc ccgggctgct caggttggcg gtgatgcggc
    15061 cggtgcaggt gaagcggggc cgctccgggg cctcgttggt gcggcattcg ggcgtgatgc
    15121 cggtggtggc cttgaaggag gcgcggaccg tggcggggtg gccggcgtcc agcccgccga
    15181 cgggcgtgaa cgaggtgttc ggcacgtaca ggtccttgac cttggcgatc tgctggtcga
    15241 ggaaggtgtc gtacgcgcgc tgcaggcccg tgtcccggcc gagccggtcg cgccaggcgt
    15301 cgaagcccgc gacgtcgttc gcgcggaggt ggccgtacat ctccttgagc agcgaggggc
    15361 gctcggccca caggaactcg aagaacgtgc cggcgtagga gtagaagcgg aagccgtcgc
    15421 ggtcgtactc cgcgtgcagc agctcgtaca cgctcatgcg cggcttggtg ccgcccgccg
    15481 tgtcgttgat gatgctctgg accagggact tgcggacctt gatgccctcg ccccgggtgg
    15541 cgccgtcgaa gaactcggcc gtgccctcgt ccatggcggt ggtgcggtcg ccctggtacc
    15601 aggggccctc gccgaaggag ccggggacgg cccagcgccc gttgaggtag tgggtgtact
    15661 cgtgccggaa gagctcctcg agcgtgagcg tggagtcctg ggggacgcgc cgctcgtacg
    15721 tgtagaaggt ggcgccgttc tcgatgtaga tgccgccgtt gttggtgccc atgccggtca
    15781 gcagcgggtg gtagacctcg tagtcggcgc gggaggcgta cagcacgatg ttgagcgtgg
    15841 tgttggtgtc gcccgccagc ggctgctcgg tgcccaggac gcggtggaac tgcgccttga
    15901 cctgcttgct cgcgtagtag aggcggtcga cggtggcgcg gggcagggcc gtgcggacct
    15961 tgatggcgcc gttgtcgtac gtgtaggtgg acgggaagat gcggcgctcg atgtcggcct
    16021 tgcacacccc gtactgcttg caggcgtcga actcgatcag ccaggtgacg accttggccc
    16081 agggctcgct gccctcgccg aagttgccgg tcgtggtgga cagcagcccg ccgaggtcgg
    16141 acgtgatccg gcccctgagc gcgtcgatct ggcccatccg cccgtactcc ccgacgccgt
    16201 cgcgcaccac ccaggcgttg gacgtgccct tgaggtgggt gtggccggcg aaggccttga
    16261 aggccgcgcg gtaggaggcg tcggccgtga cggcggcgtg gaaggcggtg tcgtggttgc
    16321 cggggtagac gcccaggtag ttgagcgaga gcgcggcgag cgcggcaccg gcccaggaag
    16381 tgtccttgtt ggtagcggaa tgcgcggcgt ccatggtggc caggacgcgc tggacgagcg
    16441 gaagctggtg ctggcgcagg cccggggagc tggccgcgta gagggcctcg cgcagggtct
    16501 cggcgttggt gcgggtcgcg tcgaaggtgc gcgaggcggt gccgaaggcg gacaccgcgc
    16561 ggcgaatcgc ctccacggtc ggcgcgtcgg tgaggtcgat ctcgctgcgg gagaagtcgt
    16621 ggtacgcgac ggcgtggagg taggtgaaca tctccagcag gtggctgttg ttcttgccgt
    16681 cgtgcgccgc ggccaggctc tcgatccggc gggagaccgc ctggacgtgc ggcctggaca
    16741 tgaccgggac cagccgctgg tcccaggtcc agatgagcgt gcgcaggcag ccgtcggcgg
    16801 tgacggcccg gtcggcgagg aagtcggcga actgctcggg ggcgaggcgc gtgatgccgt
    16861 cgagcgtgca cggcacggcg gtgccgccga gggtggcgcg gggcggtacg gccgtgggct
    16921 tcggcttggc cgtgagagcg ccggggacgc ggccgttggt gaggccgccg ggggcggtgg
    16981 gggaggcggc ggccggctcg ggcgcattcg ccagccgggt gacctcgtcg aaggggttgg
    17041 gcgtgggggt gtcctgccgc acgcccgccg ccggcggcgg ggcggacgtg gcggaggacg
    17101 gcttggccgc gggcgagggg gagtccgcgt gagcgggctg gacggcggtg gcgcagagcg
    17161 ccgtggctat ggcggtggtg agcagggatg cgcgcaggga tctgcgcagc gatctggagt
    17221 gggtcaccga tgactcctgt gtgggaggtg tgggttgccg cgcgcacacg aggtgatggg
    17281 cgtgcacgcg gcaaagcgga aacagcggaa acagcgaaga ccgtggcgca aggggtgatt
    17341 caactgccgt ctgacaggcg gcacgtgggg gactgctgct gcgccatgtc atgcgtaacg
    17401 tagtaatgtg aaatggtact gacaacccct caggcgctac gggttgtgcg cgagggcgaa
    17461 gtggcaggcc acctcacgcg cctcgcccgg cgcggcgacc cgcagcagcg gcgcctcggt
    17521 ccggcagatc tcctgcgcca tggggcagcg cgggtggaac gtgcagccgg gcgggggagc
    17581 cgccgggctc ggggggtcgc cgagcagggt gatccgctcg cgcgtccgct cggcggccgg
    17641 gtccggcagc ggcaccgccg agagcagggc ctgcgtgtac gggtgggccg gggccgcgta
    17701 cacgcgctcc ttgtcgccga cttcgacgat ccgccccaga tacatcacgg ccacccggtc
    17761 gcacacccgc ttcaccaccg acaggtcgtg ggcgatgaag aggtaggcga gcccgagttc
    17821 acgctggagc cgctccatca gattgacgat ctgggcctgc acggagacgt ccagggccga
    17881 gaccggttcg tcggcgacga tcaggcgcgg ccccgtggcg agcgcgcggg ctatgccgat
    17941 gcgctgcgcc tgcccgccgg agaactcgtg cggatagcgg tcgatgtgct cggggatgag
    18001 cccgaccagc tccatcagct ccgccgcccg cttgcgcgcc ccggccgccg gcacgccctg
    18061 gatcagcaac gggtcggcga tgatgcgggc caccgtctgg cgcgggttga gggaggagtg
    18121 cgggtcctgg aagaccatct gcaggtcctt gcgcagcggc ttgagctcgc gcctgccgag
    18181 ccggctgatg tcgcggccgt cgtaggtgat cgaccccgtc gtcggctcca ggagccgtac
    18241 gatcatgcgg ccggtggtcg acttgccgca gccggactcg cccaccaggc ccagggtctc
    18301 gcccgccgcc aggtcgaagg agacgccgtc gacggcccgg acgggtgccg cgcggccccg
    18361 cttgcccggg aaggtcatgg tcacgttccg tacggacagc aaaggtgcgg ttccggcggt
    18421 catcgggtgc ctcccggcgc atgggcggcg gtgtgcaggg acaggtggca ggagaccagg
    18481 tgccccctgg aaggccggag tccgggccgg gtgccggcgc agcgctcgcg ttcaccgggt
    18541 gccgctgcgg ccgcgcgcgg gcagcgcggt gcgaaggcgc agcccggggc cgggtccagc
    18601 agcgagggcg ggctgccggg gatggcccgc aggggagcgt cgtcggcgtc gtcgaggcgg
    18661 gggagcgagt cgagcagccc gcgggtgtag gggtggcccg ggtcggtgaa cagggtgtcg
    18721 accggggcct gttcggccgc ccggccgccg tacatcacga gcacctcgcg ggcgacgcgg
    18781 gcgacgaccc cgaggtcgtg cgtgatcatg acgacggcga gtccgcgctc ttcctgcagg
    18841 cgggcgatca gctccaggat ctgtgcctgg acggtgacgt cgagggcggt ggtcggctcg
    18901 tccgcgatga gcaggtcggg ctcgcaggcg agggccatgg cgatcatcac gcgctggcgc
    18961 atgcccccgg agaaccggtg cgggtgctcg ccggcccgcc gcgcgggctc ggggatgccg
    19021 acctcggcga gcatctcgac ggcccgtctg cgggccgccg ccctgcggga gccgaagtgg
    19081 acccggtggt gttcggcgat ctgctcgccg accgtgtaga aggggtggag gctggagagc
    19141 gggtcctgga agatcatcgc catgcggcgg ccgcgcagcc ggttcagctc gcgctcgggc
    19201 aggccggtca gctcgcggcc gtcgagggcg atggagccgg tgacgcgggc gccggtgtgc
    19261 agacccatca cggccaggga ggtgacggac ttgccggagc cggactcgcc gacgatgccg
    19321 agggtctgcc cgcggcgcac cgcgaagctg agggagtcca cggcccgtac gtccccgtgc
    19381 cgggtgggga aggtgacggt caggtccgtg acggacagca agggctgttc ctgtgaaacg
    19441 gccggtacgg ccatcagtac ctcactcgcg ggtcgacgac ggcgtagagc aggtcgacgg
    19501 ccaggttggc gacgacgatg aaggcggccg ccatcagcgt gacgccgagg atgaccggct
    19561 ggtcgccggt ggacagcgcg ccgtagaaga gccgcccgat ccccgggagc ccgaagatcg
    19621 actcggtgat gacggcgccc gcgagcagcc cgcccaggtc catgccgaag agggtgagga
    19681 tcggcgtcat gccggcccgc agcccgtgtt tgacgacgac ggtgcggcgg ggcaggccct
    19741 tggcgcgggc ggtgcggatg tacggctccg ccatcgtctc gatcatcgaa ctgcggctct
    19801 ggcgggcgta catggcggcg tagagcacgg ccagcgccag ccagggcagg agcaggttgg
    19861 acgcccagcg cagggggtcg tcgccgaggg gcacgtactg cgggtacggc agcagcccgg
    19921 ccgtccggat caggccgtag atcagcatca tcgaggtgaa gtagacgggc agcgaggccg
    19981 cggcgacggc gccgaccatc agggcgcggt cggtgagggt gtccttgcgc agggccgcgg
    20041 tgacgccggc gctcaggccg agcgccagcc acagcacggc cgcgcccagc gccagggagg
    20101 cggagaccgg caggcggtcc gtcagcaggt cccagaccgc ctcggagttc tcgtaggagt
    20161 agccgaggca ggggaaggcg cagtgcaggg cgtagcggcc gctgcccatg gtgcggccgg
    20221 tgaagatgcc ggtgacgaag tccgcgaact gccgccacag cggccggtcc aggcccatgt
    20281 gggcgcggat ggcctccagg cggtcggtgc tgcaggactt gccgcaggcg gcggccgcgg
    20341 ggtcggaggg cagcacgtag aagacggtga aggtgacggc ggcgatggcg acgagcacgc
    20401 cggcgacggc gagcaggcgg cggccgaggt agagggtcat gtgcggccgc tcctcgggtc
    20461 gaggacgtcg cgcagcgcgt cgccgagcag ggtgaaggcg aggacggtca ggaacaggca
    20521 ggtgctcggg atgacgaagt acatggggtc cgtgtcgtag aagccgacgc tctcggcgat
    20581 catctggccc caggaggggg tgggcgggcg gacgccgacg cccaggtagc tcagggccgc
    20641 ctcggtggcg atcatgccgg ggacgatgag ggtggtgtag gcgatgacgg gcccggcgac
    20701 gccggggagg atgtcgcggg tgaggatgcg ccagggcccg gagccgccga cgcgggcggc
    20761 gtcgacgtac tcgcggtgcc ggagcgagag ggtctggccg cgtacgacgc gggcgacgcc
    20821 gggccagccg aagaggccga tgacggcggt catcagcagg atgcggttga cgtccttggc
    20881 caccgacatc atcgcgatca tgaagatgag ggaggggaag gacatcgtga ggtccatcag
    20941 ccgggagagc acggcgtcgg tgcggccgcc gaagtagccc gccgtgatgc cggccgccgt
    21001 cccggcgagc acgacgatcg cggtggcggt gagggcgatc agcagcgaca cctgggcgcc
    21061 gtgcacgacc cgggcgaaca ggtcgcggcc ggtgacgggt tcgacgccga gccagtggtc
    21121 ggcggagatg ccgcccagcg gtccgagggg ccggccgccg aggtaggggt cgacggcggt
    21181 cttgtcgaac tcctcgggcg accagccggc gagcgagctc agcagcgggg cgcccgccgc
    21241 catcagcagg aagagtgcga cgacgacgag ggagaccttg acggcggtgc ggcggcgcag
    21301 ttcggcacgg gcgagctgcc agggcccgct gcccgcgggg acggccgccg gggcgggtgg
    21361 ggcggtgttc gcggtggtgg tcatggcgtg acggccctca gtcccggctc ttggcggggt
    21421 ccttgaggcc gaccgtggcg tagtcgatct gtccgccgaa ggaggtgtgc ccgtacgcgc
    21481 ccgcgatgtt ggtgcccagg accagcggcc accgccggac gagcaccggg acggccggag
    21541 cctgggcgag gatccgcccg tcgagctgct gccaggcccc ggcggcctcc ttggcgtcgg
    21601 tcatggcggc gatcgcgtcc atccgcttca tcgtcgcgtc gtcgcggaag agggagtggt
    21661 tgccggagtt gcccttctcc ttgatgaagc ggccgtcgaa gacgaagggc aggaaggtgg
    21721 agccggaggg gtagtcgggg caccagccgg tgtagaccat gtcggtgcgg ttcccggtgt
    21781 cgccgatggt ggcgtagaaa gcggacgggt ccacggtctc gatggtgacc ttgatgccgg
    21841 cccgggccag ggcctgctgg atggcctcgg cccggccctt gtcgccgacc gacgcggtga
    21901 tcttcgtcga gaagccgtcg ggcttgccgg cctccttcag cagctgctcg gccttctccg
    21961 tgtcgcccgt cgcggggatc ttgagggtgt cgggctgctt gccgccgaag agggtcgccg
    22021 gcatgtaggc ggtcgacagg tcgttgaagg cggggccgcc ggaggaggtg aggacggcgt
    22081 cccggtcgag ggcgtactgc acggcctgcc ggaccttggc gttgtcgaag ggcgctctgc
    22141 cggtgtgcat ctggaccatg tcggtgcagt tggtggactc ggcgagcagc cgctcccgca
    22201 ccccggcgtc gggcaggacc ttcgcggcgc tctccggccg cagggcgccc caggagacgg
    22261 cggaggcgtc cgcgccctgg ctcgctatca gccggtcgtc gatctggttg gccttcaggc
    22321 ccatcatgac gaccagcttg tccgggtacg ccttgcggac ttcgtccgtc gcggggtccc
    22381 agtgctcgtt gcggacgagg acgagcttct tgccgcgcgc gtaggagtcg actttgtacg
    22441 ggccggagga gaacggccgg ttgtcgtact gcgggccctt gtcctgcgcc tgcggtacgg
    22501 gcgcgaaggt gggcatgacc gtggcgttgg ggaactcggc gaacggcttg cgcagttcga
    22561 agacgatggt gcggtcgtcc ggcgtcctga tggagtcgag gtgcttgccc tgggcggggc
    22621 cccggtagcc ctcggcgccc acgaggtagc gggcggcgta gtcggcgccg ccgggcaggt
    22681 cgggggagaa ggaccgctcg acgttgtact tgacgtcctg cgcggtgacg ggtgagccgt
    22741 cctcgtactt cacgcccggc ttgaggtgga acgtccacgt cctggcgtcg gcggacggcg
    22801 agcccaggtc ggtggcgagg tcggggacca gttcgccgcc ctgcgctccg ggcgaggcct
    22861 tgtacgtgac cagggtgcgg tagagcagcc gggtcccgaa gtccatgtcg ttcatgaccc
    22921 agttgcgggc cgggtcgagg tgggtgaagt cctggttgga cagcaccgtc agcgtgccgc
    22981 ccttctgcgg ggtgccgccg atcgccttgc cctcgtgggc ggcggggttc cttccgccgt
    23041 ccttgcctcc ggccgaccgc ttcccgccgg aacacccggc cgtccccagg gcgagggagg
    23101 ccgccagcat cgcggccatg gcagtacacg tgcgcttgtt catcagtggt cactccgtga
    23161 acagtcgaac agccggacgg ctgaaatgtg acccgtaaca tagtaatgtg aaattgcact
    23221 gacaaggcgt cagtcgctcc gttacccacc tgtgtccgag gaggagtccc gtgcaggaac
    23281 ccgcagttgc cgcgatccgt acggtcagtc acgacctgcc ggtttcggcc gagttcgagg
    23341 cgttcatggc gaacggctgg gcggcgacac cgctgcccgc cgacatccgg ctgcccgtgg
    23401 cggacctcgc cgcggcgcgc cgcgcgaagc tgtcggcacg ctttcccggc gagcggctga
    23461 tcgtgcccgc gggcgagttc aaggtccgct ccaacgactg cgattaccgc ttccgcccgc
    23521 acagcgccta cgcctggctg accggactga ccggcgagga ccaggccggt cacgtgctgg
    23581 tcctggagcc cgacggcccg cactggcacg aggcggtgct gtacgtgcgg ccgcggtcgc
    23641 cgcgcgccgg tgcggagttc taccgcgacc ggcgctacgg cgagttctgg gtcggccgcc
    23701 gccccgacct cgccgaggcc gagcgcatga ccggcatccg ctgcgcgcac cgggaggact
    23761 acgaccggct gccgccgggc cgcgacgcgt ccggcgacga cgaactcgcc gccgccctga
    23821 gcgaactgcg cctggtcaag gacgcgtggg aggtcgagca gctgcagctg gccgtggacc
    23881 acaccgccgc cggcttcgag gacgtcgtgc gggcgctgcc ccgcgccctc gcccacccgc
    23941 gcggcgagcg gtggatcgag ggcgtcttcg gcctgcgcgc ccgcgccgag ggcaacggcc
    24001 ccggctacga gaccatcgcg gcctccggcg cgcacgcgtg cgtcctgcac tggatacgca
    24061 acgacggccg gctcgacccc cgcgaactcc tcctgctgga cgcgggtgtc gagacggaca
    24121 ccctctacac ctccgacatc acccgcaccc tgccgctgtc cggatgcttc tcgcccgtgc
    24181 agcggcaggt ctacgaactc gtcctcgccg cccaggacgc gggcatggcc gccctcaaac
    24241 cgggggcgag cttccgcgac ttccaccggg ccggcatgcg ggtcatcgcc gaggggctcg
    24301 ccgagtgggg cgtgctcaag agcgccgagg gcgatttcca ccgccggtac accctgtgca
    24361 gcagcggcca catgctcggc ctggacgtcc acgactgcgc ccaggcgcgg gcggacgcct
    24421 acctcgacgg cgtcctggag gaggggcagg tcctcaccgt cgagccgggg ctctacctcc
    24481 agcccgacga cgagacgctg ccggccgaac tgcgcggcat cggcgtgcgg atcgaggacg
    24541 acctggtcat cacggccgac ggggcccggc tgatgtcgca cgcgctgccc cgcacgcccg
    24601 acgcggtcga ggcgtggatg ggcgagctcc tcgagggata ggcgaactcc cccggaggat
    24661 cggggaatcg tcaaccacaa ggtacggacc ggctcttggc agcacgcagt gcaatgtgaa
    24721 atattactga cgtgctcatg agcaactcct cctcggacgt catcgtcgtc ggagcgggtg
    24781 tggtcggcgc cgcctgcgcc tactacgccg cccgcagcgg cctctccgtc accgtggtcg
    24841 accgcggccc cgtcgccggc gggaccacgg gcgccggaga gggaaacctc ctggtctccg
    24901 acaaggaacc cggaccggag ctcgaactgg ccctgctctc cacgcggttg tggcacgagc
    24961 tggcccagga gctcccggcc cggatcgagt acgaggccaa gggcggcctc gtcgtcgcct
    25021 ccgacgccgc cgccatggcc gcgctgcgga agttcgccgc cgcgcaggcc ggggcgggcg
    25081 tcacggccga ggagatcccg gccgaccggc tgcacgacgt ggagccgcac ctggcccccg
    25141 gcctcggagg cggcttccgc tatccgcagg acgcccaggt ccagcccgcc ctcgccgccg
    25201 cccacctgct gcgcgcctcc ggcgcccggg tccgtaccgg agaggaggtc accgccgtcc
    25261 tcaccggtgc ggacggagag gtgcggggcg tgcgtacggc ggccggcgag ctgcacgccc
    25321 ccttcgtcgt caacgccgcc ggcacctggg gtggcgaggt ggcccggctc gccggcgggc
    25381 acctgcccgt actgccccgc cggggcttcg tgctcgtcac cgaaccgctg ccgcgcgtgg
    25441 tgcggcacaa ggtctacgcg gccgactacg tcgccgacgt ggccagcggc tcggcggagc
    25501 tgcagacctc cgcggtggtc gagggcaccc cggcgggccc ggtcctgatc ggcgccagcc
    25561 gcgaacgggt cggcttcgac cgcaccctgt cggtggaggt gctccggcgc ctcgccgccc
    25621 aggccacggc cctgttcccg gtgctggccg gagtacgggc cctgcgcacg tacgccggat
    25681 tccgcccgta cctgcccgac cacctgcccg ccatcggccc cgacccccgc gtccccgggc
    25741 tgctgcacgc ctgcggccac gaaggcgcgg ggatcgggct cgcccccgcc accggcctgg
    25801 ccgtcgcccg gcagctgacg ggcggcgaac ccccgctcga cctcggcccg ttccgccccg
    25861 gccgcttcgc cccggccgcc tgaacccccg gccgcctgaa ccccgggccg cctgaccccc
    25921 cttcccgcgt ccgcccgttg ccccgcaccg tcccgagagg aggcccgcac gtggcccgta
    25981 cccccgccga cctggtcagg gcggagcccg acccgccctt cgagatcacc ttcgacggcc
    26041 gtacggtcac cgccctgccc ggccagtccg tggccgccgc cctgtgggcg gcgggcatcc
    26101 tcgcctggcg caccacccgg tacggcggcc gcccgcgcgg ggccttctgc ggcatcgggc
    26161 agtgctacga ctgcctcgcc accgtcaacg gcgagcccaa ccgccgggcc tgcctggtgc
    26221 ccgcccggcc cggggacgcg atcaccaccc aggaaggaca cggccgtgcc gggctcgccg
    26281 tctgaaccgt acgacctcgc cgtgatcggc gcgggacccg ccggcctcgc cggggccgcc
    26341 accgctgccc ggctcggcct gtccgtcgcc gtcctggacg ccgccgcgca ggtaggcggc
    26401 cagtacttcc gtcaccccgc cccgggcctg ggcgccgcgc acccgcaggc cctccaccac
    26461 gactgggccg ccttcaccga gctgcgcggg cgcttcgagg tgagcggcgc cgcgcacttg
    26521 gccgggcacc acgtgtgggc cgtcacgcgg cgggacgagg aagtgtggag cgtgcacgcg
    26581 ctcgtgggcg aggagggcgg cgcgaacgcg ggacgcgcgg gcggtgcggc ctccggcagc
    26641 ggcggggcgg gcgcagccgt ctccggcacc gggagcgacg acgtttcggg tacccgcagc
    26701 agcggcaccg gaagaagctg cgaaggccgc accgaagcga gcttcagcgg cgaacgcgag
    26761 cgccccgtgc gcctgcacgc ccgcgccgtg ctcttcgcca ccggcgcggg cgagcggcag
    26821 ctgcccttcc ccgggtggac cctgcccggc gtcgtcgggg ccggtggcgc ccaggccatg
    26881 ctgaagtccg ggctcgtcct gcccgggcag cggatcgtcg tggcgggcag cggtccgctc
    26941 ctgctcgccg tcgcctcctc gctcgccgcc gccggcgccc gcgtccccgc ggtggccgag
    27001 gcgtccggct acctcggcta cgcccgcagg ccgggcgccc tggcggccaa cccccacaag
    27061 ctcctcgaag ccgccgtcca cggcacggca ctcgtgcgcc accgcatccc gctgcacacc
    27121 cgcagcgcgg tcaccgaggt gcacggcacc gaccgcgtcg aggccgtcac cgtctcccgg
    27181 ctcgaccgcg actggcggcc cgtgcccggc acgggccgcc gcatcgcctg cgacgccctg
    27241 gccgtgggcc acgggctcgc accgcagacc gagctcgcca ccggcctcgg ctgcgagacc
    27301 cggcgcacgc ccgacggcac gcacgccctc gtcctggacg gcctccagga gacctcggtg
    27361 cccggcctgt gggccgccgg cgaggccggc gggaccggcg gctggcaact cgcccgcgtc
    27421 gagggcgagc tggcgggcat cgcggtggcc gcccggctgc gggcgctccc cgcgctcacc
    27481 cggagccggc gcgtacggga cctggcccgg cgccgcgacc gcatgcgcgc cttcgccgac
    27541 gccatggccg ccgcccacgc acccggcccc ggctggaccg cgtggctcga cgacgacacc
    27601 gacgtctgcc gctgcgagga ggtgaccgcc ggaagcatcc gcgaggccgt caccgaattc
    27661 ggcgcccggg acgcccggac cgtcaagctc ctcacccggg ccggcatggg ctggtgccag
    27721 ggccggatgt gcggcgcggc cgtggcctgc ctcgcggcgt ccggtacggc gcaggggacc
    27781 gtaccgccgt ccgccgagcg caggccgctc gccgtgcccg taccgctggg ctccctcgcc
    27841 gccggacccg aggaacccgg agacgcctga accaccgccc cacccgcgct cgtacacgtc
    27901 ccacgccata gaacgccata gaagggttac cggtatgacc gcctcctcct ggacccccga
    27961 ccgcccctgg cgcggcatca tggtcgccac caccctcccg ctgcgcccgg acctctccgt
    28021 cgactacgac gcctacgccg aacacgtccg ccggctcgtc gagaacgggt gcgacggcgt
    28081 cgtccccaac ggctccctcg gcgaatacca gaccctcacc ccgcaggagc gcgcccgcgt
    28141 cgtgcgcacc gccgtcgagg cggccgggga cggggcgcgg gtgatgcccg gcgtcgccgc
    28201 gtacggcagc gccgaggcgc gccactgggc cgagcaggcc gccgaggcgg gctgcggctc
    28261 cgtcctgctg ctgccgccga acgcctaccg cgccggcgaa caggccgtcc gcgcccacta
    28321 cacggaggtc gccgcggccg ggataccggt cgtcgcctac aacaacccca tcgacacgaa
    28381 ggtcgacctg accccggccc tgctggcccg gctgcacgcc gacggcagca tcgtggccgt
    28441 caaggagttc accggcgacg tccggcgcgc ctacgagatc gccgaactcg cccccgaact
    28501 cgacctgctg atcggcgcgg acgacgtcct cctcgaactc gccaccgcgg gtgccgtcgg
    28561 ctggatcgcg ggctacccca acgccttccc cgccacctgc gccgcgctct accgcgccgc
    28621 cgtcgccggg gacctccaga cggcgctgcc cctctaccgc tcgctgcacc cgctcctgcg
    28681 ctgggactcg aagaccgagt tcgtgcaggc catcaagctc tccatggaca tcaccggcca
    28741 ccacggcggg cccacccgcc cgccgcgcct gccgctcacc ggcgagaccg aggccgcggt
    28801 gcgcgccgcc acggagaagg ccgtcgccga cggacaccac tgaccccgcc cgcctccggg
    28861 ctttccttcc agccgtatcc ccctgccgaa agaaaggaca tccgtgcgta cccgtcatgt
    28921 cttccatgcc gtcgactcgc acaccgaggg catgcccacg cgcgtcatca ccggtggcgt
    28981 cggcgtgatc cccggcgcca ccatggccga gcgccggctc cacttcatcg agcacatgga
    29041 ccacctgcgc acgctcctga tgtacgagcc gcgcggccac gcctcgatga gcggcgcgat
    29101 cctgcagccc cccacccggc ccgacgccga ctacggggtc ctctacatcg aggtctccgg
    29161 ggtgctgccg atgtgcgggc acggcaccat cggggtcgcc accgtgctcg tcgagacggg
    29221 catggtgccg gtcagcgaac cggtgaccac cgtgcgcctc gacaccccgt ccggtctgat
    29281 caccgtcgac gtccaggtcg aggacggcgc ggccaagtcc gtcacgctcg tcaacgtgcc
    29341 ctccttcagc gtcggtctcg accgcaaggc cgacgtcccc ggccacggga cggtcaccta
    29401 cgacctcgcc ttcggcggca acttctacgc cttcgtcgaa ctcgacgccc tggggctgcc
    29461 cttcgaccgg gcacgcaagg acgacctgct cgccgccggg ctcgccgtca tggaggcggt
    29521 caacgcctcg ccggaccggc ccgtccaccc cgaacacccc gagatcaacg gcctcaagca
    29581 cgtctacctc gcggcccccg gctcggacgc ccgccactcc cggcacgcca tggccatcca
    29641 ccccggctgg ttcgaccgtt ccccctgcgg cacgggcacc tccgcccgga tggcacagct
    29701 gcacgcccgc ggcgcgctcc cgctcgacag ggacttcgtc aacgagtcct tcatcggcac
    29761 gcggttcacc ggccgcctgg tgggggagac gcaggtcggc ggagtgccgg cggtcgtgcc
    29821 cgccatcacc ggccgcgcct ggatcaccgg caccgcccag tacttcctcg acccggacga
    29881 ccccttcccc ggaggtttcc tcctgtgacc gccgccccga cctccttcgc ctcgcacaac
    29941 ccggccgacc cgtccgacgt cgtctgcgac gtgcccgcgt ccggtgcctc cggcgccgcc
    30001 gaggccgtcg agcaggcccg tgccgcccag cccggctggc tgcaggccgg tgccgccgcc
    30061 cgctcctccg cgctctccgc cgtcgccgcg gcggtcgagg ccgcggccgg cgaactcgcc
    30121 gccctcgccg tgcgcgaggt gggcaagccc ctcgccgagg cgcgggccga ggtggcccgc
    30181 acggccgcga tctggcggta ctacgcccag gcgccctacg agcccaccgg cgccgtccac
    30241 gagacggccg gcggccccgg cctgctgctg acccggcgcc gcccgcacgg cgtcgccggc
    30301 ctcatcacgc cctggaactt ccccttcgcc atcccgtcct ggaaggccgc gcccgcgctg
    30361 gccgcgggca acacggtcgt cctcaagccc gcgcccgagg ccaccgcgtg cgccctgcgc
    30421 ctcgccgagc tcgtccggca ggcgctgccc gccgcggtgt tcacggtcgt gcccggcggt
    30481 gcgaccgagg ggaacgccgt cctcgcgacc gccgacgccg tctccttcac cggctccacc
    30541 gccgtcggcg ccgtggtcac ccgcgccgcc accgcccggg gcatcccggt ccaggccgag
    30601 acgggcgggc tcaacgcggc gatcgtcctg cccgacgccg acatcgggcg ggcagcggcc
    30661 cacatcgccg cggccgtcgc cggatacgcc gggcagaagt gcacggcgac cagccgggtg
    30721 atcgccgtcg gcgcggccct ggatcccctg cgcgaggccc tcgccgaagc cctgcgcgcc
    30781 ctgccggtgg gcgacccggc cgacccggcc accgtgtgcg gccccctcat ctcggcccgg
    30841 gcccggggcc gcttcgacca ggccctctcc ggcgcctccg tcctggccgc gggcaccgcc
    30901 ccggaaggcc ccggctggta cgcggcgccc accgtggcag aaaaggtccc ggccggtcac
    30961 cggctgctca ccgaggaggt cttcgccccc gtcgccgccc tgctgcccgc ggacgacctg
    31021 ccgcacgccg tacggatcag caactccgtt ccgtacggcc tggtcacctc ggtccacacc
    31081 ggcgggctcg aagcggcgct gcacggtctc gacggcctcg acacgggcat gatccgtgtc
    31141 aacgcccctt ccacgggcgt cgacttccac ctgccgttcg gcggcaccaa ggcctccggg
    31201 cacggccctc gcgagcaggg gcgcgcggcg ctggagttct acacctccag ccggacctac
    31261 accctcgctc cctgagaaag atgtgacatt gtacgctcgt tggtccgccc aggtacggac
    31321 cagccgggga gcgcggctgt gcacgtaccg cggacgcggc tgccggacct cggccgccgc
    31381 accggcgacg aagggacacg ggaccatggg ccacctcaag cagcgcactc tcatcaccgc
    31441 caccgagcgg ctgcgcgacc aggtcgccca cgccttgcgg gccgcgctga tctccggcga
    31501 actccacccc ggcgaggtct actccgcgcc gcagctcgcg gaggacttcg gcatctccgc
    31561 gaccccggtg cgcgaggcca tgctcgacct cgcccgcgag ggcctggtcg agccggtccg
    31621 caacaagggg ttccgggtga ccgaggtcaa cgagcgcgac ctggaccagt acaccgagat
    31681 ccgcacgctc atcgaggtcc ccacgaccgg ccgcgtcacg cgcaccgccg cccgcgagga
    31741 cctcgaagcc ctccgcccgg tcgccgagga gatcgtgcgc gccgcccgcg accacgacct
    31801 catcggctac ctggaggccg accggcagtt ccacctcacc ctgctggccc tctccggcaa
    31861 cgaacgcctc gtcgagaccg tcggcgacct gcgcaagcgc tcgcgcctgt acgggctgac
    31921 cgcgctcgac cggcgcggcg aactcatccc ctccgccgag gaacacctcg aactgctcga
    31981 cctgatgctg gccggcgacg ccgagggcgc cgagcagtgc atggcacggc acctcggaca
    32041 cgtgcgctcc ctgtgggcga agggcagcag cgacaaggac tcatgaccgc gcgcgggaag
    32101 ccggcggctt cggcgcgcgc gagaaggagg gcgacatgcg cacctcaccc ctgatcgcgg
    32161 cggccctcgc cggctgcctg gcggtccccg cgacggcctg ggcgtccccc gcccggcccc
    32221 cgtccgcgcg cggctgtgcg ctcaagggca cgacgggctg gacggacgag ggccacgaca
    32281 ccgaccccgt ccgcttccgg cgcgccaccg gcacgcaccg cgtcctgacc ctgttcgccg
    32341 acttccccga cgcacaggcc accggcccca ccgccccgta cgccgcccac ctcgcccccg
    32401 ccgccgactg gctgcgcaag gcctcctacg ggcggacgcg gctgcagatc acgccgctgc
    32461 accgctggat ccggatgccg gcgccctcca cctcctacgg cttccagcgc ggcctcacct
    32521 tcgaggccca cgagcgctac ctccgcgacg cggtgacggc cgccgacccg tacgcggact
    32581 tctcccgcta cgacatggtg tacgtcgtcc ccgcgagaga agcgtccgcg atctccttct
    32641 ccccgaccta cctcttcgac cccgccacgc ccggcgtcac ggccgacggc acccgcatcc
    32701 gatgggccgt caccttcggg caggacatgt ggcgctgggg gcacaaggtc gccgcccacg
    32761 agaccggcca cgtcttcggc ctgcccgacc tctacgcctt cacgggcggg acccaccgcc
    32821 acgtcggcgg ctgggacctc atgggcaaca tcgccggcac cgccccgcag
//
