LOCUS       NZ_LNBE01000002        20927 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_2, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000002
VERSION     NZ_LNBE01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1142035)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 194890
            Orig. end                         :: 215817
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20927
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20927
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10927](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10927)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(211..855)
                     /locus_tag="AS857_RS02730"
     CDS             complement(211..855)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131608.1"
                     /locus_tag="AS857_RS02730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_058041483.1"
                     /transl_table=11
                     /translation="METSQREDQQHAAERRRKELLEAADRVVLREGPGASMNAIAAEAG
                     ITKPILYRHFGDKGGLYRALAARHTDALLVGLRAALDAPAERRDRVERTLDSYLAAIEA
                     RPQVYRFLMHPADEGHPSEQGFDVGRHSAPLLRRMGEELAQVISERVDLGPDSDELSRA
                     WGHGIVGMMHAAGDWWLRERPFPREHLVRHLADLLWGRLASSGDLPGGPGF"
     misc_feature    846..862
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    complement(983..994)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.47"
                     /tool="antismash"
     gene            1014..2240
                     /locus_tag="AS857_RS02735"
     CDS             1014..2240
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492557.1"
                     /locus_tag="AS857_RS02735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_058041484.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.6e-16, bitscore:
                     55.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.5e-25, bitscore:
                     83.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.7e-53, bitscore:
                     174.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEFTMELNEDQRGVRDWIHGFAAEVMRPAAAEWDEREEFPWPVV
                     QEAARIGLYSLDFYAQQFFDPTGLGVPMAMEELFWGDAGLGLAITGTGLAAIGVLTNGT
                     EEQIGTWLPQMYGDADDVKIAAFCSSEPDAGSDVSAMRTRAVYDEAKDEWVLDGTKTWA
                     TNGGIANVHVVVAVVDPGLGARGHASFVVPPGTPGLSQGQKFKKHGIRASHTAEVVLDG
                     VRLPGHCLLGGKDKLDERLARARERVRTGGARTHNAAMATFEASRPTVGAQAVGIARAA
                     YEVALDYAQTRHQFGRPVIDNQGVAFQLADMRTRIDAARLLVWRASWMASAGKPFTAAE
                     GSMSKLFAGETAKAVTAQAMQILGGNGYTREYPVERMHRDAAIYTIFEGTSEIQRLVIA
                     RTISDVPIR"
     gene            2289..2675
                     /locus_tag="AS857_RS02740"
     CDS             2289..2675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239330.1"
                     /locus_tag="AS857_RS02740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_058041485.1"
                     /transl_table=11
                     /translation="MLHHLELWVPDLQRAEKSFGWLLGALGYTPHQHWENGRSWRLGAF
                     YLVVEQSPALAAGTHERCRPGMNHVAFPVESRAAVDALVEEAPEHGWQLMFSGRHPFAG
                     GPDHYAAYLENEDGFEAELVAAGV"
     misc_feature    complement(2697..2706)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     misc_feature    2723..2737
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.64"
                     /tool="antismash"
     gene            2807..4531
                     /locus_tag="AS857_RS02745"
     CDS             2807..4531
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062428.1"
                     /locus_tag="AS857_RS02745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_063804145.1"
                     /transl_table=11
                     /translation="MNLDSTAGVVEAARGGDDAAQDQLVAACLPLVYNIVGRALNGHAD
                     VDDVVQETMIRMVGGLHALRDPEGFRSWLVAITMNQIRSHWRKELKDRKDAPSGGLQEV
                     GEAAAPEPDFVEWSIIRLGLQGQRRQAAQATRWLDGDDQVVMALWWQEAAGELSRAEVA
                     AALGRSPQYTAVRVQRTKGQLETARVVVRALATDPRCPELTDVIGDWDGAPSPLWRKRI
                     ARHARGCAECGGHWSALVPAEGLLAGLGLVPVGAALLARVSGAVPGGPMTACAANTPAT
                     TPATAPGSASAGAPEPSGEAAPPGEQAPGTPADLGRLARRAVVAAGVVAVVVGGTLGGP
                     HLFNAAPESARPQTPGAPVQVVPVTAGDPAPAGPDRTDATAVARSDTDGRAPVRASAPA
                     VPPAPAPVATPAAAKSPSRPAAEKQTAPSAPPAGTGAGAGATPRRTPPPAAPGAGPAQE
                     VVRIVNTERAKAGCGPVHFSAELVAVAQRHTGDTASRTPAGQWSAFARRAAVPGHHWSS
                     YGVNAATGQSSASAVVSVWMNDPGHRRTILNCAYTELGVGVSFAYDGPRWMQVFAAR"
     gene            4660..6645
                     /locus_tag="AS857_RS02750"
     CDS             4660..6645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262356.1"
                     /locus_tag="AS857_RS02750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_245699556.1"
                     /transl_table=11
                     /translation="MILTAAAAAAAAGIAFGVLSTGSATSTPGPQPEAANAPAAQPVQK
                     KPPAPLTSTPRADKQRGLVYDGLKPAPKGDRCVGVYSVSRAGLCTHGPDAPPKGVDITK
                     DTPPVAGKTAAPSSLTGDGAQAPSASEALGGAPSVVDARKGGVAAAAATGPGTPANPQA
                     GSGSKVVCEGDGSSGNRVQVLYVHAPGRDRFGQYAASFKQWAAETDVIYNASAKETGGE
                     RHVRYVTEADCTASVLNVEVSAGDLQEFGAMNNALAAKGFNRRDRKYMVFADAQVYCGI
                     GTFNGDERPGQDNLSNFGPSYGRTDSGCWGGSTPAHELGHNLGAVNNSAPHTSRAAHCV
                     DEWDIMCYSDAPHYPKMQVLCPERTGDQRLDCGHDDYFHTSPKPGSYLATHWNIANNRF
                     LMAGGGSTNPDPGPTPTRTPDPTRPPAAGPDAQVSQITPNSAVVSWPKVPSATGYDLLV
                     NGKRTADVKDAVVRLTGLAPGTSYKVALAARGADGKASAPGRAASFRTLSTDGGSTTRP
                     GTAYVMVNGLTGEALDLWGGSAADGTVAIAYQRHGYANQQWSFENAGGGALRVKSVQSG
                     KCLQLGGGDRPVAGQYVAQQPCRDTAAQKWRLNAAGGGSYVLQPEGSSLVLGISKRSYY
                     GGRLLELQQKNDQGYQSWTLSKAAAS"
     gene            6757..7389
                     /locus_tag="AS857_RS02755"
     CDS             6757..7389
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS02755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_058041487.1"
                     /transl_table=11
                     /translation="MKLRPTTLAPALGCAAALLVLGTPGTAAAHGDTIHFAVGGEQRGG
                     HVRTVATWENDGDPVDEPVAGTLTATGPDGRTAGPWQLVAAEGGKGAYTTRETLPEGTW
                     KVVVHCGFPDLGHGEGTVTVAAGTAEAGHGPAPAGSATASERSAPAGPAAARREAVPTE
                     AEETAQAPASSSRTGLVVGACAAVVVAAAAAVLLVRARRSRKAAVTK"
     gene            complement(7399..8451)
                     /locus_tag="AS857_RS02760"
     CDS             complement(7399..8451)
                     /NRPS_PKS="Domain: PKS_ER (19-270). E-value: 3.7e-13.
                     Score: 41.2. Matches aSDomain:
                     nrpspksdomains_AS857_RS02760_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999412.1"
                     /locus_tag="AS857_RS02760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_058041488.1"
                     /sec_met_domain="ADH_N (E-value: 9.8e-25, bitscore: 82.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.1e-21, bitscore:
                     72.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTMLAGRLDLRSGAFAVEEIPVPRPGPGQVRVKVEAAGICLSD
                     VHLIDGSLKPVRTQADKITLGHETAGVVDALGPGVPAEWTVGRRVLLQAGERCGTCRSC
                     ERFTAPCLRLLTRGVDYDGGWAEYALAGHHTLVALPDDLPFEQAAIIPDAVSTPWSAIT
                     LTGRARAARPAGVWGTGGLGAHAVQLLRLVGAAPVIAVDPLEAARRRALDFGADLALDP
                     ADPGLRARILAATDGHGLDLALDTAGVPAVREQAAGCLAADGRLVLVGLGPGPLTVGNS
                     IAFSVRHQQILGHYGSEPGHVDELVTLARLGRLDLGRSISGTLPLAEAAAGVERLRKKE
                     GDPIRLVLTP"
     aSDomain        complement(7642..8394)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS02760_PKS_ER.1"
                     /evalue="3.70E-13"
                     /label="AS857_RS02760_PKS_ER.1"
                     /locus_tag="AS857_RS02760"
                     /protein_end="270"
                     /protein_start="19"
                     /score="41.2"
                     /tool="antismash"
                     /translation="EEIPVPRPGPGQVRVKVEAAGICLSDVHLIDGSLKPVRTQADKIT
                     LGHETAGVVDALGPGVPAEWTVGRRVLLQAGERCGTCRSCERFTAPCLRLLTRGVDYDG
                     GWAEYALAGHHTLVALPDDLPFEQAAIIPDAVSTPWSAITLTGRARAARPAGVWGTGGL
                     GAHAVQLLRLVGAAPVIAVDPLEAARRRALDFGADLALDPADPGLRARILAATDGHGLD
                     LALDTAGVPAVREQAAGCLAADGRLVLVG"
     gene            complement(8468..9451)
                     /locus_tag="AS857_RS02765"
     CDS             complement(8468..9451)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-310). E-value:
                     1.6e-29. Score: 95.1. Matches aSDomain:
                     nrpspksdomains_AS857_RS02765_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712409.1"
                     /locus_tag="AS857_RS02765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_058041489.1"
                     /sec_met_domain="PF00561 (E-value: 9.5e-25, bitscore: 83.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.5e-17, bitscore:
                     60.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSVEHRFVEVNGVTLHIAEQGRGPLVVLLHGFPECWYSWRHQF
                     GPLAGAGYRVVAVDQRGYARSEQPDDTGAYSLLHLAGDVIALIHALGEESAVVVGHDWG
                     APVAWTTALLRPDVVRGVAGLSVPPQPHGPAAPLPALRSVFGDGFYQLYFQEPGVADAE
                     LARDPATSFRRILFSGSGDSPQTDPPRPWVVPAGRTLLDTMAEPEELPGWFTDEDVDVF
                     VREFSAHGDRAFTGGLNWYRNLDRNWELLAPFHGLRIEVPALYVGGDRDPVRAFPGMER
                     LLASLEETVPGLRRSVTLPGCGHWTQQERPEEVNAELLEFLSSLNA"
     aSDomain        complement(8522..9376)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS02765_Abhydrolase_1.1"
                     /evalue="1.60E-29"
                     /label="AS857_RS02765_Abhydrolase_1.1"
                     /locus_tag="AS857_RS02765"
                     /protein_end="310"
                     /protein_start="25"
                     /score="95.1"
                     /tool="antismash"
                     /translation="PLVVLLHGFPECWYSWRHQFGPLAGAGYRVVAVDQRGYARSEQPD
                     DTGAYSLLHLAGDVIALIHALGEESAVVVGHDWGAPVAWTTALLRPDVVRGVAGLSVPP
                     QPHGPAAPLPALRSVFGDGFYQLYFQEPGVADAELARDPATSFRRILFSGSGDSPQTDP
                     PRPWVVPAGRTLLDTMAEPEELPGWFTDEDVDVFVREFSAHGDRAFTGGLNWYRNLDRN
                     WELLAPFHGLRIEVPALYVGGDRDPVRAFPGMERLLASLEETVPGLRRSVTLPGCGHWT
                     QQER"
     gene            complement(9545..9847)
                     /locus_tag="AS857_RS02770"
     CDS             complement(9545..9847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953812.1"
                     /locus_tag="AS857_RS02770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_058041490.1"
                     /transl_table=11
                     /translation="MDEEEDRRLRAIAPEISHTTIGLMRTIVGLEPAERVPEEALKVAD
                     RVLAKHGTDGLRVLVMSLSGWMAVGIENVAHLKGQTNEAIIDDIELTCLEANPDG"
     gene            complement(10001..10927)
                     /locus_tag="AS857_RS02775"
     CDS             complement(10001..10927)
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145757.1"
                     /locus_tag="AS857_RS02775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_058041491.1"
                     /sec_met_domain="phytoene_synt (E-value: 6e-26, bitscore:
                     87.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 7.5e-08,
                     bitscore: 27.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTWNKALDVAGVHDRQLRDDYTRQRDLVARYRRHAYAAVRLLL
                     PGATVPHVIAMTAFMHHTDNVLDSGSTLAERASAYAVWEKDVREALAGGRADHPVIRPV
                     LHTVAARPGLTGAVEDFLKAAPADLDFTGFATEGAYQDYVDAYSLPAFMLVAGLLDPGT
                     DPGAYRAACRSYIDGSQRLDFVNDLAEDLEGGRLALPRETLEQHGVSRGDLESARDTPA
                     VRVLLAGQLRRARHDLLAARRLAGLTSPVDRPFVRAMVELEVLTADAAAAKGCGLLRGP
                     ARPSAGPALRMFLREFGRALAARRRAL"
     gene            11055..11450
                     /locus_tag="AS857_RS02780"
     CDS             11055..11450
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949284.1"
                     /locus_tag="AS857_RS02780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_058041492.1"
                     /transl_table=11
                     /translation="MEPWLLTDVERAVRSSWGADTCTPEYRSRWTPDNPARDQCGVTAM
                     VLNDLLGGELIRGEVRVDGVQTDFHWWNRLGEGVEIDLTREQFSPEEIVTGGLVIPRPP
                     EIKRLREEYELLRERVLEKLRAGAAAH"
     gene            11635..12480
                     /locus_tag="AS857_RS02785"
     CDS             11635..12480
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (71-178). E-value: 9.4e-26. Score:
                     81.8. Matches aSDomain: nrpspksdomains_AS857_RS02785_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644836.1"
                     /locus_tag="AS857_RS02785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_058041493.1"
                     /transl_table=11
                     /translation="MHKETSQEANEEATRSYYDSGDVDAFYDAVWGGEDIHTGIYTRPG
                     EPIAEASRRTVERVADRLAGGLGPGGTVIDLGSGYGGTARRLAERFGCRVVALNLSAAQ
                     NERHRAVNAERGLAGLVEVVTGSFHDIPFPDGHFDAVCSLEAFCHSNDRPKVLSEAARV
                     LKPGGVLAFTDLMAAEDAPAEALRPAVSRLGVDALATVSFYRDRLARLGLSGVGFDDHS
                     GQLVNHYVRLTEETAARAAELGGRIGAAYLGHLQENLPVWVDAARRGRLQWGVLYGRRP
                     "
     aSDomain        11848..12168
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS02785_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="9.40E-26"
                     /label="AS857_RS02785_oMT.1"
                     /locus_tag="AS857_RS02785"
                     /protein_end="178"
                     /protein_start="71"
                     /score="81.8"
                     /tool="antismash"
                     /translation="TVIDLGSGYGGTARRLAERFGCRVVALNLSAAQNERHRAVNAERG
                     LAGLVEVVTGSFHDIPFPDGHFDAVCSLEAFCHSNDRPKVLSEAARVLKPGGVLAFTDL
                     MAA"
     gene            12580..13356
                     /locus_tag="AS857_RS02790"
     CDS             12580..13356
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010475297.1"
                     /locus_tag="AS857_RS02790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_079110012.1"
                     /transl_table=11
                     /translation="MFYCAFKAVVLVPLLRWLFRPRVEGLGRVPQHGAAIVAGNHQSFT
                     DQFLMGVTLRRRISFLAKQEYFTGRGIKGRLAAAFFRGLGAIPVDRSGRGAGQAAVEEG
                     VKVLGRGELLGIFPEGTRSHDGRLYKGKVGVAEMAIRSGAPVVPCAMIGTFEAQPAGRR
                     LPRLVPVTVRFGEPLDFSRYAGMADQRHVLRAVTDEIMYAILKLSEQEYVDVYAVDARA
                     RLSALGSGPAGAEVLGSTRFAPGPDRAAPGEDRTAA"
     gene            complement(13480..13995)
                     /locus_tag="AS857_RS02795"
     CDS             complement(13480..13995)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118011.1"
                     /locus_tag="AS857_RS02795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_058041494.1"
                     /transl_table=11
                     /translation="MKIESKPAGQDGQTPEAARDPRTPGIRSGAQRKRDVLERLGRELD
                     IWVASAGADGVPCLVPLWFLWDGEAIWMSTRPANPTGRNLRDGGRARLALGHTRDVVLI
                     DGDVETYGTHEVPAAAADAFARNSGWDPRKEGGAYAYFKVVPRAVQAWHEEPELRGRHL
                     MRDGEWLV"
     gene            14089..14814
                     /locus_tag="AS857_RS02800"
     CDS             14089..14814
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944428.1"
                     /locus_tag="AS857_RS02800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_058041495.1"
                     /transl_table=11
                     /translation="MNDDVRNIVLGLVVSGISAAAGWFVRTLLWRRQLRRKQIFFGLPA
                     GSECLLVVNQDPTATGWGVARHDAFALLEISALIKECGAHADIVVHDAARQGIGVRTEF
                     CVGAPVSNRRTEAHLRSLLPGVAVATGHGGPEEGALTVGGETYRVDKGKTEYVLLARLT
                     GPGGSRPVFLASGQRSVTNQAAIGYLARHHRRLAHRYGLDGTFCLLLKVVNSDAYGPDM
                     VELVSDVTAAATTTPSPAR"
     gene            complement(14915..16060)
                     /locus_tag="AS857_RS02805"
     CDS             complement(14915..16060)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006351075.1"
                     /locus_tag="AS857_RS02805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoaspartyl peptidase/L-asparaginase"
                     /protein_id="WP_245699557.1"
                     /transl_table=11
                     /translation="MRSRLWILPVITALVAVAVALPALSQPSARPEDAAAVAAGPGRGT
                     PPRPEATDVVLAVHGGAGTALRREDTDARTEKAYRDGLADALRAGRKVLRDGGGSVAAV
                     EAAVRSLEDNALFNAGKGAVFTEDAGHELDASVMRGSDLAAGAVAGVRHVRNPVSAARL
                     VMERTPHVLLAGEGADSFAVRNGLPAVTQDYYWTQARWDSLMKAKEQSRGGTSPSASGK
                     AVDGRAVGSKAVGESAMGTVGAVAVDRKHDLAAATSTGGMTNKMAGRVGDSPLVGAGTY
                     AKNGTVAASATGHGEVFIRGAATSTISHLIEFGGRDVAAAAHEVVHERLTRLGGTGGVI
                     ALGPDGVLAAPHSSEGMLYGYLTADGEIVTRVFPDESRTGR"
     misc_feature    16196..16209
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.52"
                     /tool="antismash"
     gene            16264..17865
                     /locus_tag="AS857_RS02810"
     CDS             16264..17865
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539468.1"
                     /locus_tag="AS857_RS02810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_058041497.1"
                     /transl_table=11
                     /translation="MITVRGAGIRAGARLLMSDVSFHIAPGDRIGLVGRNGAGKTTLMR
                     TLAGELRPAAGDITVTGSLGYLPQDAQAADPATLLTDRILSARGMDRAVRALRAAEDAM
                     AKAGGAAAQERAMAAYARAEADFQARGGYAAEAEAARVAAGVGLPARSMGEPLGALSGG
                     QRRRAELARILFAGHGTLLLDEPTNHLDADATAWLRTFLTSHQGGLVLISHDTGLLADT
                     VNRVFHLDAHRATVDVHNTGWSAYLARRGADERRRTRERANAERKAAALRTQADRMRAN
                     VATAVAAKNMVRRADRMLAALEPARRTERTARIRLPEPAPCGRTPLGAVSLVKAYGGRS
                     VLGGVDLAVDRGSRLAVLGLNGAGKTTLLKILAGREAPDSGRVVHGHGLRLGYFAQEHE
                     TLDPALTVRQNLAAAAPHLSDGEARHVLGAFLFGGDDADKPAGVLSGGERTRLALAGLV
                     HSGANVLLLDEPTNNLDPASRDEVLGAVGAYPGALVMVTHDEGAVEALRPDRVLLLPDG
                     TEDLWDDGYLDLVSSA"
     gene            complement(17984..18745)
                     /locus_tag="AS857_RS02815"
     CDS             complement(17984..18745)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953108.1"
                     /locus_tag="AS857_RS02815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_058041498.1"
                     /transl_table=11
                     /translation="MSRSFDDLVAEAEAAPVAGWDFSWLDGRATEERPSWGYQRTMSER
                     LALADAALDIQTGGGEVLAGARKLPRTMVATESWPPNVAKATRLLHPLGAVVVADADEP
                     PLPFADEAFDLVTSRHPATVWWEEIARVLRPGGTYLAQHVGPASAFELVEYFLGPQPEE
                     VRRRRHPDDERRDAEAAGLGVVDLRAETLRMEFRDVGAVIYFLRKVIWMVPGFTVGQYR
                     DRLRELHERITAEGPFVARSARFLIEARKPV"
     misc_feature    complement(18856..18871)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.89"
                     /tool="antismash"
     misc_feature    18857..18870
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.73"
                     /tool="antismash"
     gene            18924..19865
                     /locus_tag="AS857_RS38510"
     CDS             18924..19865
                     /EC_number="3.5.1.28"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891208.1"
                     /locus_tag="AS857_RS38510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_107105491.1"
                     /transl_table=11
                     /translation="MAWYPGATKMELQPESDDQPAIRPTQFILHSVGAPWTARRLYEFW
                     RDSTNLESHFGLGYGGDLAQYIGTQTRADANYRANLRPDGSGAVSIETASNLEHTDPWT
                     GRQVDRLVEVGVWLHQYHGLPLRVCRSWDEPGYGYHRLFPQWSSGGTACPGDARVGQFH
                     DVVFPAIVARASSRPADPKPGGAAPRTLGEYTDAQTALVPGAWTTLSVNGETLISGATA
                     YTATVFLTVSVPAGSTLQGRFYHQRADGSRWNGPIVERIATVGASFVDFTHHGSVSEGE
                     TVRFEACYDPPAPGVRDPGTVSTSRARGLYWT"
     misc_feature    19299..19301
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20122..20135)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    20894..20909
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.91"
                     /tool="antismash"
ORIGIN
        1 gcgcgtgacc ggcaccggct tcttcgcccg ctgcctgcag cacgagtgcg accacctcga
       61 cggcgggctc tacctcgacc acgtgacggg gctgcgccgc cgccgggcgc tgcgggccgt
      121 acgccgtgcg ccgtgggcgg ggcgcacgga ggcgcagccg gagccggccc gtacggcgta
      181 gggcgtacgg gcggccggcc gcggcacgcg tcagaagccc gggccgcccg gcaggtcgcc
      241 cgaggaggcg agccgtcccc acagcaggtc cgcgaggtgg cgcaccaggt gctcccgggg
      301 gaaggggcgc tcgcgcagcc accagtcgcc ggcggcgtgc atcatgccga cgatgccgtg
      361 gccccaggcg cgcgacagct cgtcgctgtc gggaccgagg tcgacgcgct ccgatatgac
      421 ctgggcgagc tcctcgccca tccgccgcag caggggagcg gagtgccgcc cgacgtcgaa
      481 gccctgctcg gaggggtggc cctcgtcggc ggggtgcatc aggaagcggt agacctgcgg
      541 ccgggcctct atggccgcga ggtagctgtc gagcgtccgc tcgacgcggt cgcggcgctc
      601 ggcgggggcg tccagcgcgg cccgcagccc cacgagcagc gcgtcggtgt gccgggccgc
      661 cagggcgcgg tagagcccgc ccttgtcgcc gaagtgccgg tagaggatgg gcttggtgat
      721 gcccgcctcg gccgcgatgg cgttcatcga cgcaccgggc ccctcgcgca gcaccacccg
      781 gtccgccgcc tcgagcagct ccttgcggcg ccgctccgcc gcatgctgct ggtcctcccg
      841 ctgactggtt tccatatgac ctgcctcccc gcccctgtga ttcctgacgc ctgcgcaacg
      901 taacacccgc tccacccagc gaatccggga ggcgggacgg ttgacactac taccggtcgg
      961 taacatactc atgttaccgc gagtaagggt tttccgcagg ggtgggagag gccatggccg
     1021 aattcacgat ggagctcaac gaggaccagc ggggggtgcg cgactggatc cacggcttcg
     1081 cggccgaggt gatgcgcccg gccgccgccg agtgggacga gcgcgaggag ttcccgtggc
     1141 cggtcgtcca ggaggccgcc cgcatcgggc tgtactcgct cgacttctac gcccagcagt
     1201 tcttcgaccc caccggcctc ggcgtcccca tggccatgga ggagctcttc tggggcgacg
     1261 ccggcctcgg cctcgccatc accgggaccg ggctcgccgc catcggcgtc ctcaccaacg
     1321 gcaccgagga gcagatcggc acctggctcc cgcagatgta cggcgacgcc gacgacgtga
     1381 agatcgccgc cttctgctcc tccgagccgg acgcgggctc ggacgtctcg gccatgcgca
     1441 cccgcgccgt ctacgacgag gccaaggacg aatgggtcct cgacgggacg aagacctggg
     1501 cgacgaacgg cggcatcgcg aacgtgcacg tcgtcgtcgc ggtcgtcgac cccgggctgg
     1561 gcgcgcgcgg ccacgcctcc ttcgtcgtcc cgccgggcac cccggggctc tcccaggggc
     1621 agaagttcaa gaagcacggc atccgcgcct cgcacaccgc cgaggtcgtc ctcgacggcg
     1681 tccgcctgcc cggccactgc ctcctcggcg gcaaggacaa gctggacgag cgcctggccc
     1741 gcgcccgcga gcgcgtgcgc accggcggtg cccgtacgca caacgccgcc atggccacct
     1801 tcgaggcctc ccgccccacg gtcggcgccc aggccgtcgg catcgcccgc gccgcgtacg
     1861 aggtggcgct cgactacgcc cagacgcgcc accagttcgg ccggcccgtc atcgacaacc
     1921 agggcgtcgc cttccagctc gcggacatgc gcacccgcat cgacgcggcc cggctgctgg
     1981 tgtggcgcgc gtcctggatg gccagcgcgg gcaagccctt caccgcggcg gagggctcga
     2041 tgtccaagct gttcgcgggc gagacggcga aggccgtcac ggcccaggcc atgcagatcc
     2101 tcggcgggaa cggctacacg cgcgagtatc cggtggaacg gatgcaccgg gatgcggcca
     2161 tttacaccat ttttgagggc acgagcgaga tccagcggct ggtgatcgcc cgtacgatct
     2221 ccgacgtgcc gatccggtga gccccggccc ggccggaccg accacctgac cgccgggggg
     2281 cgtggggcgt gcttcaccat ctcgaactgt gggtgcccga cctgcagcgc gccgagaaga
     2341 gcttcggctg gctgctcggc gccctgggct acacacccca ccagcactgg gagaacggcc
     2401 gcagctggcg gctcggcgcc ttctacctcg tcgtcgagca gtcgcccgcg ctcgcggccg
     2461 gcacccacga gcgatgccgg ccgggcatga accacgtcgc cttccccgtg gagagccggg
     2521 ctgccgtcga cgcgctcgtg gaagaggccc cggagcacgg ctggcagctg atgttctccg
     2581 gcaggcaccc gttcgccggc gggcccgacc actacgccgc gtacctggag aacgaggacg
     2641 gcttcgaggc cgaactcgtc gccgccgggg tttgagcacc cgtcataccc accccggcaa
     2701 aaaagattcc gccgaaccac agatttttct gttatccgca tcgcgccccc aggtctccca
     2761 tgcgtaagac cgccgatgcg gtggagcgga aagaggtggg cggaacgtga acttggacag
     2821 cacggccggt gtggtcgagg cggcgcgcgg cggggacgac gccgcgcagg accagctggt
     2881 cgcagcctgc cttccgttgg tctacaacat cgtcggccgc gccctgaacg ggcacgcgga
     2941 cgtcgacgac gtcgtgcagg agaccatgat ccggatggtc ggcggcctgc acgccctgcg
     3001 ggaccccgaa gggttccgct cgtggctcgt cgcgatcacc atgaaccaga tacgcagcca
     3061 ctggcgcaag gagctcaagg accgcaagga cgcgccgtcc ggcggcctgc aggaggtcgg
     3121 cgaagccgcc gcccccgagc ccgacttcgt cgagtggtcg atcatccgcc tcggtctgca
     3181 gggacagcgc agacaggccg cgcaggccac gcgctggctc gacggcgacg accaggtcgt
     3241 catggccctg tggtggcagg aggccgcggg cgagctgagc cgcgccgagg tcgccgcggc
     3301 cctgggccgc tcgccgcagt acaccgccgt ccgggtccag cgcaccaagg gccagctgga
     3361 gaccgcccgc gtcgtcgtcc gcgcgctcgc cacggacccg cgctgccccg aactcacgga
     3421 cgtcatcggc gactgggacg gcgcgccgag cccgctgtgg cgcaagcgca tcgcccggca
     3481 cgcgcgcggc tgcgcggagt gcggcgggca ctggtccgcg ctcgtgcccg cggaagggct
     3541 gctggccggc ctcgggctcg tccccgtcgg cgccgccctg ctcgcccggg tgagcggagc
     3601 ggtccccggc ggccccatga cggcctgcgc cgccaacact cccgccacta ctcccgccac
     3661 cgctcccggc agcgcctccg ccggggcccc ggagccgtct ggggaggcgg caccacccgg
     3721 ggagcaggcg ccgggcaccc ccgccgactt ggggcgcctg gcgcgccggg ccgtcgtcgc
     3781 cgccggtgtc gtggccgtcg tcgtgggcgg cacgctgggc ggcccgcacc tcttcaacgc
     3841 cgcgcccgag agcgcccgtc cgcagacccc cggcgccccg gtccaggtcg tcccggtcac
     3901 cgccggcgac cccgcgccgg ccggaccgga ccgcaccgac gccacggccg tcgcccgctc
     3961 cgacaccgac ggccgcgccc ccgtgcgcgc ctccgccccc gccgtaccgc cggccccggc
     4021 acccgtcgcg acccccgccg cggccaagag cccctccagg cccgccgccg agaagcagac
     4081 cgccccgagc gcgccccccg ccggaaccgg agccggagcc ggagccacgc cccggcggac
     4141 accgccgccg gccgccccgg gcgcgggccc cgcccaggag gtcgtccgca tcgtcaacac
     4201 cgaacgcgcc aaggccggat gcgggcccgt gcacttcagc gccgagctcg tggccgtcgc
     4261 ccagcgccac accggcgaca ccgcctcgcg cacccccgcc ggccagtggt ccgccttcgc
     4321 ccgccgggcg gccgtgcccg gccaccactg gagctcgtac ggggtgaacg ccgccaccgg
     4381 gcagagcagc gcctccgccg tcgtgtccgt gtggatgaac gaccccgggc accgccggac
     4441 catcctcaat tgcgcctaca cggagctggg cgtcggcgtc tccttcgcct acgacggccc
     4501 gcgctggatg caggtcttcg cggcgcgctg agcgccgccc cgagccaccc ccctccgccg
     4561 ggccggccag cgccccgccc ggccgttccg taacccccac cgataggaac tcctttgccg
     4621 cgcaaacact cccaccgccg cagcagaacc ggtcgccgcg tgatactcac ggcggccgca
     4681 gccgccgcgg ccgccggaat cgccttcggc gtcctgagca ccggatccgc cacctccacc
     4741 ccgggcccgc agccggaggc ggcgaacgcc cccgccgcgc agccggtgca aaagaagccg
     4801 cccgcccccc tcacctcgac cccccgcgcc gacaagcaac gcggtctcgt ctacgacggc
     4861 ctcaagcccg cccccaaggg cgaccgctgc gtcggcgtct acagcgtctc gcgggccggc
     4921 ctgtgcaccc acggccccga cgccccgccc aagggcgtcg acatcaccaa ggacaccccg
     4981 cccgtggcgg ggaagacggc cgccccctcc tccctgaccg gtgacggcgc ccaggcaccc
     5041 tcggcctccg aggccctcgg cggagcgccg tccgtggtcg acgcccgcaa gggcggcgtg
     5101 gcggcggccg ccgccacggg cccgggcacg cccgcgaacc cgcaggcggg ctccggctcc
     5161 aaggtcgtct gcgagggcga cggttcgagc ggcaaccgcg tccaggtcct gtacgtccac
     5221 gcacccgggc gcgaccggtt cggccagtac gccgcctcct tcaagcagtg ggcggccgag
     5281 accgacgtca tctacaacgc cagcgccaag gagaccggcg gcgagcggca cgtccgctac
     5341 gtcaccgagg ccgactgcac cgcctccgtc ctgaacgtcg aggtctccgc gggcgacctg
     5401 caggagttcg gggccatgaa caacgccctg gccgccaagg gcttcaaccg ccgcgaccgc
     5461 aagtacatgg tcttcgccga cgcccaggtc tactgcggca tcggcacctt caacggcgac
     5521 gagcggcccg gccaggacaa cctcagcaac ttcggcccgt cctacggccg tacggactcc
     5581 ggctgctggg gcggcagcac ccccgcccac gaactgggcc acaacctcgg cgccgtcaac
     5641 aacagcgccc cgcacaccag cagggccgcg cactgcgtcg acgagtggga catcatgtgc
     5701 tactcggacg ccccgcacta ccccaagatg caggtcctgt gccccgagcg cacgggggac
     5761 cagcggctgg actgcggcca cgacgactac ttccacacct cgcccaagcc cggcagctac
     5821 ctggccaccc actggaacat cgccaacaac cgcttcctga tggcgggcgg gggcagcacg
     5881 aaccccgacc ccggccccac gccgacccgc acccccgacc cgacgcggcc gccggcggcc
     5941 gggcccgacg cccaggtcag ccagatcacc ccgaactcgg ccgtcgtcag ctggccgaag
     6001 gttccctcgg ccaccggcta cgacctgctg gtcaacggga agaggacggc cgacgtgaag
     6061 gacgccgtcg tccgcctcac gggcctggcc cccggcacct cctacaaggt cgccctcgcc
     6121 gcgcgcggcg ccgacggcaa ggcctccgca ccgggccgcg ccgcgtcctt ccgcaccctc
     6181 tccaccgacg gcggctccac gacccggccg ggcaccgcgt acgtgatggt caacggcctc
     6241 accggcgagg ccctcgacct gtggggcggc tccgcggcgg acggcaccgt cgccatcgcc
     6301 taccagcgcc acggctacgc caaccagcag tggtccttcg agaacgccgg cggcggcgct
     6361 ctgcgcgtga agtcggtcca gagcggcaag tgcctccagc tgggcggcgg agacaggcct
     6421 gtggccggcc agtacgtggc ccagcagccc tgccgggaca ccgccgcgca gaagtggcgg
     6481 ctgaacgccg caggcggcgg gtcgtacgtc ctgcagcccg agggctcgtc cctggtactg
     6541 ggcatcagca agcgctcgta ctacggcggc cgcctgctcg aactccagca gaagaacgac
     6601 cagggatacc agagctggac cctgtcgaag gccgccgcct cctgacggcc gcccattgaa
     6661 ccgggccggc gaccgctgct tcttcttccc cccccaccgg cggtcgccgg ccccttctgc
     6721 cccgcccctc ccgacacccc ctgaggaacc gtcacgatga agctgcgccc caccaccctg
     6781 gccccggcgc tcggatgcgc cgccgccctg ctcgtcctgg gcacgcccgg aacggccgcc
     6841 gcgcacggcg acaccatcca cttcgccgtc ggcggcgagc agcggggcgg ccacgtacgg
     6901 accgtggcga cctgggagaa cgacggcgac cccgtggacg agcccgtcgc cggcaccctg
     6961 acggccaccg gcccggacgg gcgcaccgcg ggcccgtggc agctcgtggc cgccgagggc
     7021 gggaaggggg cctacaccac ccgcgagacc ctgccggagg gcacgtggaa ggtcgtcgtc
     7081 cactgcggct tcccggacct cggccacggg gaggggacgg tcacggtcgc ggccgggacc
     7141 gcggaggccg ggcacggtcc tgctccggcc gggagcgcca ccgcgtcgga gcggtccgcg
     7201 ccggccggcc cggcggccgc ccggcgggaa gcggtgccca cggaggccga ggagaccgcg
     7261 caggcccccg cgtcctcctc ccgtacgggc ctcgtcgtcg gcgcctgcgc ggccgtcgtc
     7321 gtggctgcgg ccgccgcggt gctcctggtg cgggccaggc gctcgcggaa ggccgccgtc
     7381 accaagtgag ggtcggcatc acggggtgag gaccagccgg atcgggtcgc cctccttctt
     7441 gcggagccgc tcgaccccgg cggcggcctc cgccagcggc agcgtgccgc tgatggagcg
     7501 gccgaggtcg aggcggccca ggcgggcgag ggtgaccagt tcgtcgacgt gcccgggctc
     7561 cgagccgtag tgcccgagga tctgctggtg ccggacgctg aaggcgatgc tgttgccgac
     7621 cgtcagcggc ccggggccga ggccgacgag gaccaggcgg ccgtccgccg ccagacagcc
     7681 ggcggcctgc tcgcgcacgg cgggcacccc ggcagtgtcg agcgcgaggt ccagcccgtg
     7741 gccgtcggtc gccgccagga tgcgcgcgcg caggccgggg tcggcggggt cgagggcgag
     7801 gtcggcgccg aagtcgagcg cccgccgccg ggccgcctcc agggggtcga cggcgatgac
     7861 cggcgcggcc ccgacgaggc gcagcagctg cacggcgtgc gcgccgaggc cgcccgtgcc
     7921 ccacactccc gccgggcggg cggcgcgggc ccggcccgtc agggtgatcg cggaccacgg
     7981 cgtggagacg gcgtccggga tgatcgcggc ctgctcgaac ggcaggtcgt cggggagggc
     8041 gaccagcgtg tggtgaccgg ccagggcgta ctcggcccag ccgccgtcgt agtccactcc
     8101 gcgggtcagc aggcgcaggc acggcgcggt gaagcgctcg caggaacggc aggtgccgca
     8161 gcgctcgccc gcctgcagca ggacgcggcg gcccacggtc cactccgccg gcacgccggg
     8221 gcccagggcg tcgacgacgc cggcggtctc gtggccgagc gtgatcttgt cggcctgtgt
     8281 gcggacgggc ttgaggctgc cgtcgatgag gtgcacgtcg gacaggcaga tgccggcggc
     8341 ctcgaccttg acgcggacct gccccggccc cggccggggg acgggtatct cctcgacggc
     8401 gaacgcgccg gagcgcaggt cgagtcttcc ggcgagcatc gtgtcactca tggcaggggc
     8461 ctcccggcta cgcgttcagg gacgacagga actcgaggag ctcggcgttg acttcctccg
     8521 gccgctcctg ctgcgtccag tgaccgcagc ccggcagggt cacgctgcgg cgcagccccg
     8581 gcaccgtctc ctccagggac gccagcagcc gctccatgcc ggggaaggcc cggacagggt
     8641 cgcggtcgcc cccgacgtac agcgcgggca cctcgatgcg gaggccgtgg aagggcgcga
     8701 ggagctccca gttccggtcg aggttgcggt accagttcag gccgccggtg aaggcgcggt
     8761 cgccgtgcgc ggagaactcg cgcacgaaga cgtccacgtc ctcatcggtg aaccagcccg
     8821 gcagctcctc gggctccgcc atcgtgtcca ggagcgtgcg gccggccggg acgacccacg
     8881 ggcgcggcgg gtcggtctgc gggctgtcac ccgagccgct gaacaggatc cggcggaacg
     8941 acgtcgccgg atcccgcgcc aactccgcgt cggcgacgcc gggttcctgg aagtagagct
     9001 ggtagaagcc gtcgccgaac acggagcgca gcgccggcag cggggccgcc gggccgtgcg
     9061 gctgcggcgg cacgctcagg ccggccacgc cgcggacgac gtcgggccgc agcagcgccg
     9121 tggtccaggc gaccggcgcg ccccagtcgt gcccgacgac gaccgcgctc tcctcgccga
     9181 gggcgtggat cagggcgatc acgtcaccgg cgaggtgcag caggctgtac gcgccggtgt
     9241 cgtccggctg ttcgctgcgc gcatacccgc gctgatcgac ggcgacgacc cggtacccgg
     9301 ctccggccag cggcccgaac tggtgccgcc aggagtacca gcactccggg aagccgtgca
     9361 gcaggacgac caggggcccg cgcccctgct cggcgatgtg cagcgttact ccgttgacct
     9421 cgacgaagcg gtgctcgacc gagctggtca tggtgtcctc ccgggggcgt cacgccgacg
     9481 tactccacag tagggggcgg cttccccgcg gcgggcgaga cgttgaccac tcggccggtc
     9541 cgcctcagcc gtcggggttg gcctccagac aggtcagttc gatgtcgtcg atgatggcct
     9601 cgttcgtctg gcccttcagg tgcgcgacgt tctcgatgcc gaccgccatc caccccgaca
     9661 ggctcatgac gagcacccgc agcccgtccg taccgtgctt ggcgagcacc cggtccgcca
     9721 ccttgagcgc ttcttcgggc acccgttccg ccggttcgag gccgacgatg gtgcgcatca
     9781 gcccgatggt ggtgtgcgag atctccggtg cgatcgcccg cagcctccgg tcctcttcct
     9841 cgtccacgtg tcctcgattc gtccgtcagc cggtcacgtg caagcaccct aggtggccgc
     9901 gcgcggcggc cgcagcccga acaccaacgg gtgatcgctg ctacgggtga atcccggtca
     9961 agaagctccc aagtggccac cggcgatgct cggaacgccc tcagagggcg cggcgccggg
    10021 cggccagcgc acggccgaac tcccggagga acatccgcag cgcgggaccg gccgaagggc
    10081 gcgccggccc ccgcagcagg ccgcagccct tcgccgccgc ggcgtccgca gtgagcacct
    10141 ccagctcaac catcgcccgc acgaacggac ggtccaccgg tgaggtgagg ccggccaggc
    10201 ggcgggcggc cagcaggtcg tggcgcgcgc ggcgcaactg accggccagg agcacccgta
    10261 cggccggggt gtcgcgtgcc gactccaggt cgccgcggga gacgccgtgc tgctccaggg
    10321 tctcccgggg gagggccagg cgcccgccct ccaggtcctc ggcgaggtcg ttgacgaagt
    10381 ccaggcgctg gctgccgtcg atgtacgaac ggcaggccgc gcggtacgcg ccggggtcgg
    10441 tgcccgggtc gagcaggccg gcgacgagca tgaacgccgg cagcgagtag gcgtcgacgt
    10501 agtcctggta ggcgccttcc gtcgcgaacc cggtgaagtc gagatcggcc ggcgcggcct
    10561 tcaggaagtc ctcgaccgct ccggtgagcc cgggccgggc ggcgacggtg tggagcaccg
    10621 gccggatcac cggatggtcc gcgcgcccgc cggccagggc ctcgcgtacg tccttctccc
    10681 acacggcgta ggcggaggcg cgctcggcca gggtgctgcc gctgtcgagc acgttgtccg
    10741 tgtggtgcat gaacgcggtc atggcgatga cgtgcgggac ggtcgcgccg ggcagcagca
    10801 gccggaccgc cgcgtaggcg tggcgccggt agcgtgcgac gaggtcgcgc tgccgcgtgt
    10861 agtcgtcgcg cagttgccgg tcatggacgc cggcgacgtc gagcgccttg ttccacgtgc
    10921 tcgtcatgga tcccttttcc catcggctgg ttccggccgc tgcgggccac ggaggactgt
    10981 acgtcgtggg cgccggcagg cgtcggttcg caggctctcc gggattgtca gtggtcactg
    11041 ccaggatgcg cagcatggaa ccgtggcttc tcaccgacgt cgagcgcgcc gtccgcagca
    11101 gctggggcgc cgacacgtgc acccccgagt accggtctcg ctggaccccg gacaatccgg
    11161 cgcgcgatca atgcggcgtc accgcgatgg tcctcaacga cctgctgggc ggtgagctca
    11221 tccggggcga ggtccgcgtc gacggcgtgc agaccgactt ccactggtgg aaccggctcg
    11281 gcgagggcgt ggagatcgac ctcacccgcg agcagttctc ccccgaagag atcgtcaccg
    11341 gcggcctggt cataccgcgc ccgcccgaga tcaagcgcct ccgcgaggag tacgagctcc
    11401 tgcgcgaacg cgtcctggag aagctgcggg cgggcgcggc cgcgcactag gcgcacgggc
    11461 gtccctcggc caaggggtgc cgcgtgcact cctcggccgg ctcctccgcg tggccgggag
    11521 gtcctcgccc gcctacaggc gacgcggccc gatcatggct ggttcgtccc tgtgttcacc
    11581 gccgtgcgga ggtgaggctg atcccgaccg gtcctgcgga cgagaggagc acctgtgcac
    11641 aaggaaacga gccaggaagc gaacgaggaa gcgacgcgca gctactacga ctccggcgac
    11701 gtggacgcct tctacgacgc ggtctggggc ggcgaggaca tccacaccgg catctacacc
    11761 cgccccggcg agccgatagc cgaggcctcc cgccgtaccg tcgagcgggt cgcggaccgg
    11821 ctcgccggcg gcctcggccc cggcggcacc gtcatcgacc tcggttccgg atacggaggg
    11881 accgcccgcc ggctcgccga gcgcttcggc tgccgcgtcg tcgccctcaa cctcagcgcc
    11941 gcccagaacg agcggcaccg cgccgtcaac gccgagcgcg gcctcgccgg tctcgtcgag
    12001 gtcgtcaccg ggtccttcca cgacataccg ttccccgacg gccacttcga cgccgtgtgc
    12061 tccctggagg ccttctgcca cagcaatgac cggccgaagg tgctgagcga ggcggcccgc
    12121 gtgctcaagc ccgggggcgt gctggccttc accgacctga tggccgccga ggacgccccc
    12181 gcggaggcgc tgcgcccggc cgtctcccgc ctgggcgtgg acgccctggc caccgtgtcc
    12241 ttctaccgcg accggctcgc ccgcctcggc ctgtccggcg tcggattcga cgaccacagc
    12301 ggccaactgg tcaaccatta tgttcggctg accgaggaga cggcggcgcg cgcggcggag
    12361 ctcggcgggc gcatcggcgc cgcctacctc ggccacctgc aggagaacct gcccgtatgg
    12421 gtggacgccg cgcgccgcgg acggctgcag tggggcgtcc tgtacggacg ccgtccgtaa
    12481 ccaaccggcc acggtctggc tcaatcggcc ttctcccgct gatccatacc cgcgagtagc
    12541 gtgcccgggc gcgggggtct ctgggagaag ggcgtttgca tgttctattg cgcgttcaag
    12601 gccgtggtgc tggtcccgct gctgcggtgg ctcttccggc cgagggtgga ggggctggga
    12661 cgggtcccgc agcacggcgc ggcgatcgtc gcgggcaacc accagtcgtt caccgaccag
    12721 ttcctgatgg gcgtgaccct ccggcgccgg atcagcttcc tcgccaagca ggagtacttc
    12781 accggccgcg gcatcaaggg caggctcgcc gccgccttct tccgcggcct cggcgcgata
    12841 cccgtcgacc gctccggccg cggcgcgggc caggccgccg tcgaggaggg cgtgaaggtg
    12901 ctcggccgcg gcgaactcct cggcatcttc cccgagggca cgcgctcgca cgacggacgg
    12961 ctgtacaagg gcaaggtcgg cgtcgccgag atggccatcc gctccggcgc gcccgtcgtg
    13021 ccgtgcgcga tgatcggcac gttcgaggcc cagcccgcgg ggcggcggct gccgcgcctg
    13081 gtgcccgtca cggtccgctt cggcgaaccc ctggacttct cccgctacgc gggcatggcg
    13141 gaccagcggc acgtgctgcg cgcggtcacc gacgagatca tgtacgcgat cctgaagctg
    13201 tcggagcagg agtacgtcga cgtgtacgcc gtcgacgcca gggcccggct gagcgccctc
    13261 ggttcgggcc cggccggcgc cgaggtcctg gggagcacgc ggttcgctcc cggcccggac
    13321 cgcgcggctc ccggagagga ccgcaccgcg gcgtagggac gcacatccgt gggggcgggc
    13381 gcgccgggcg gccggcagga gatccgccgg accgcgcggc cgcgccctcc ggcgccggcc
    13441 gccgtccgtc ccccgggcgg gcccgcctcc gcccgccgct cagacgagcc actcgccgtc
    13501 gcgcatcaaa tggcggccac ggagctcggg ttcctcgtgc cacgcctgca cggcgcgcgg
    13561 caccaccttg aagtaggcgt acgcgccgcc ctccttgcgg gggtcccagc ccgagttccg
    13621 ggcgaacgcg tcggccgccg cggccggcac ctcgtgcgtg ccgtacgtct cgacgtcgcc
    13681 gtcgatcagg acgacgtcgc gcgtgtgccc gagggcgagc cgggcccggc cgccgtcgcg
    13741 caggttgcgg cccgtcgggt tggccggccg ggtcgacatc cagatcgcct ccccgtccca
    13801 caggaaccac agcggcacca ggcacggcac cccgtcggcg ccggccgagg cgacccagat
    13861 gtccagctcc cgccccagcc gctccaggac gtcccgcttg cgctgcgctc cgctgcggat
    13921 cccgggcgtc cgcgggtccc gtgccgcctc cggggtctgc ccgtcctgcc cggccggctt
    13981 cgattcgatc ttcatgcccg gacgctaccc gcacgggctt ccaggcgcct cgggctgtgg
    14041 ccgtagggcc gtcgaccgac ccggcccggg cccgtaggct gcccgctcat gaacgacgac
    14101 gtgcgcaaca tcgtgctggg actggtcgtc agcgggatca gcgccgccgc gggctggttc
    14161 gtcaggaccc tgctgtggcg gcgccaactc cggcgcaagc agatcttctt cggcctgccg
    14221 gcgggctcgg agtgcctgct cgtggtcaac caggacccga ccgcgaccgg ctggggcgtc
    14281 gcgcggcacg acgccttcgc gctgctggag atatccgcgc tgatcaagga gtgcggggcg
    14341 cacgcggaca tcgtggtgca cgacgccgcc cgccagggga tcggcgtgcg caccgagttc
    14401 tgcgtcggtg ctcccgtgtc gaaccggcgc accgaggccc acctgcgctc gctgctgccc
    14461 ggcgttgcgg tggccaccgg ccacggcggg ccggaggagg gcgcgctcac cgtcggcggc
    14521 gagacgtacc gggtggacaa ggggaagacc gagtacgtcc tgctcgcccg gctgaccggg
    14581 cccggcggca gccggccggt cttcctcgcc tccggccagc gcagcgtcac caaccaggcg
    14641 gccatagggt acctggcccg gcaccacaga cggctcgccc accgttacgg gctcgacggc
    14701 acgttctgcc tcctgctgaa ggtcgtgaac tcggacgcgt acgggccgga catggtggaa
    14761 ctggtctccg acgtcaccgc ggcggccacc accacgccgt cccccgcccg ctgaccgcag
    14821 ccccgttccc cgccgggggc acccgatccg gcggtgcggg cggtgcggcg gtcccctgag
    14881 tgcctgccca tgtacccgta cgcgcggtga gccgtcaccg gccggtgcgc gactcgtcgg
    14941 ggaacaccct cgtgacgatc tcgccgtcgg ccgtcagata gccgtagagc atgccctcgc
    15001 tgctgtgcgg ggcggcgagc accccgtcgg ggccgagtgc gatcacgccg cccgtgccgc
    15061 ccagccgggt gagccgctcg tgcaccactt cgtgggcggc cgcggccacg tccctgcctc
    15121 cgaactcgat caggtgcgag atggtggacg tggcggcacc gcggatgaac acctcgccgt
    15181 gcccggtcgc gctggccgcc accgttccgt tcttcgcgta cgtccctgct cccacgagag
    15241 gggagtcgcc cacgcggccg gccatcttgt tggtcatccc gcccgtggag gtcgcggcgg
    15301 cgaggtcgtg cttgcggtcg acggccacgg cgccgaccgt acccatcgcg gactcgccga
    15361 cggccttgct gccgacggcc ctcccatcga cggctttccc gctcgcggac ggcgaagttc
    15421 cgcccctgct ctgctccttg gccttcatga ggctgtccca acgcgcctgc gtccagtagt
    15481 agtcctgggt gaccgccggc aggccgttgc gcacggcgaa gctgtcggcg ccctcgcccg
    15541 ccagcagcac gtgcggcgtg cgctccatca cgaggcgggc ggcggagacg gggttgcgca
    15601 cgtggcgcac gccggccacg gcaccggccg ccaggtccga gccgcgcatg accgacgcgt
    15661 ccagctcgtg ccccgcgtcc tcggtgaaca ccgcgccctt gcccgcgttg aacagggcgt
    15721 tgtcctccag cgaccgcacg gccgcctcga ccgcggccac gctgccgccg ccgtcccgca
    15781 gaaccttccg gccggcgcgc agggcgtcgg ccagcccgtc gcggtaggcc ttctccgtac
    15841 gggcgtcggt gtcctcccgc cgcaacgccg taccggcgcc gccgtgcacg gccagcacca
    15901 cgtcggtcgc ctccggccgg ggaggggtcc ctcggccggg gccggcggcc accgcggcgg
    15961 catcctccgg ccgggccgac ggctgcgaca gcgcgggcag tgccaccgcg accgccacca
    16021 gggcggtgat tacgggaagg atccagagtc tcgaacgcat gcgcatgggc ctctctcctt
    16081 cgctttcgcg atccgggctc gctgcacggg gcgttcgccg gtccgggcgc gcacgtaatc
    16141 cggatgcgca cgccgcgctc gcgcggctac cctcggcccc atgtctacgc cccgcatttc
    16201 ttagctcaag gaccccactc cacgccaccc gtgtgtcctt gagctgttcc ggagcgtaat
    16261 cccatgatca ccgttcgcgg tgccggcatc cgtgccggcg cccgcctcct gatgtccgac
    16321 gtctccttcc acatcgcccc cggcgaccgc atcggcctgg tcggccgcaa cggcgccggc
    16381 aagacgaccc tgatgaggac cctggccggc gagctccggc ccgccgccgg agacatcacc
    16441 gtcaccggct ccctcggcta cctcccgcag gacgcgcaag ccgccgaccc cgccaccctc
    16501 ctcaccgacc ggatcctctc cgcccgcggc atggaccggg ccgtccgcgc gctgcgggcc
    16561 gccgaagacg ccatggcgaa ggccggcggc gcggccgccc aggagcgggc catggccgcg
    16621 tacgcccggg cggaggccga cttccaggcc cgcggcggat acgccgccga ggccgaggcc
    16681 gcccgcgtcg ccgccggggt ggggctgccc gcccgcagca tgggcgaacc gctgggcgcc
    16741 ctgtccggcg ggcagcggcg gcgggccgag ctggcccgca tcctcttcgc cggccacggc
    16801 accctgctgc tcgacgagcc gaccaaccac ctggacgccg acgcgaccgc ctggctgcgc
    16861 accttcctga cgtcccacca aggcggactg gtgctgatca gccacgacac cggcctgctg
    16921 gccgacaccg tcaaccgcgt cttccacctc gacgcgcacc gcgccaccgt cgacgtccac
    16981 aacaccggct ggagcgcgta cctggcccgg cgcggggccg acgagcggcg ccgcacccgg
    17041 gaacgggcga acgccgaacg caaggcggcc gcgctgcgca cccaggcgga ccggatgcgc
    17101 gcgaacgtcg cgaccgccgt cgcggcgaag aacatggtcc gccgcgccga ccggatgctc
    17161 gccgccctcg aaccggcccg ccggacggag cggacggccc ggatccggct gcccgagccc
    17221 gccccctgcg ggcgcacccc cctgggagcc gtcagcctcg tcaaggccta cggcggccgg
    17281 agcgtcctcg gcggcgtcga cctcgccgtc gaccggggca gccgcctcgc cgtcctcggc
    17341 ctcaacggcg ccggcaagac cacgctgctg aagatcctcg ccgggcgcga ggcccccgac
    17401 agcggccgcg tcgtccacgg ccacggcctg cgcctcggct acttcgccca ggagcacgag
    17461 acgctcgacc ccgcgctgac ggtgcggcag aacctggccg cggccgctcc ccatctgagc
    17521 gacggggagg cccggcacgt gctcggagcc ttcctcttcg gcggcgacga cgccgacaag
    17581 ccggccgggg tgctctccgg aggcgagagg accaggctgg ccctggccgg cctggtgcac
    17641 tccggcgcca acgtgctgct gctggacgag ccgaccaaca acctcgaccc ggcctcgcgc
    17701 gacgaggtgc tcggtgcggt cggcgcctac cccggcgccc tcgtgatggt gacgcacgac
    17761 gagggcgccg tcgaggcgct gcgcccggac cgggtcctcc tgctgccgga cggcacggag
    17821 gacctgtggg acgacggcta cctggatctg gtgtcctcgg cctgagaccg gcatgcgggt
    17881 ggcgcggcgg cgggtcgcgc tcggcgggag gccgcgtggc ctcccgccgg gtcacgggct
    17941 tgcgggcttg agggtcacgg gctgcgggtc acgggcttgc gggtcacacg ggcttgcggg
    18001 cctcgatgag gaagcgcgcc gagcgggcga cgaaggggcc ttcggccgtg atgcgttcgt
    18061 gcagttcgcg cagccggtcg cggtactggc cgacggtgaa cccggggacc atccagatca
    18121 ccttccgcag gaagtagatc accgcgccga cgtcgcggaa ctccatccgc agcgtctcgg
    18181 cgcgcaggtc gacgacgccg agccccgcgg cctccgcgtc ccgccgctcg tcgtcggggt
    18241 ggcgcctgcg ccgcacctcc tccggctgcg ggcccaggaa gtactcgacc agctcgaagg
    18301 cgctggccgg gcccacgtgc tgcgccaggt acgtgccgcc cggccgcagc acccgggcga
    18361 tctcctccca ccacacggtc gccgggtgac ggctggtcac gaggtcgaac gcctcgtcgg
    18421 cgaagggcag gggaggctcg tcggcatcgg cgaccacgac cgccccgagg gggtgcagca
    18481 gcctcgtcgc cttggcgacg ttgggcggcc aggactccgt ggccaccatc gtgcggggca
    18541 gcttccgcgc gccggcgagg acctccccgc cgcccgtctg gatgtcgagg gccgcgtccg
    18601 cgagggccag gcgctcgctc atggtgcgct gatagcccca ggagggacgc tcctcggtgg
    18661 cccggccgtc cagccaggag aagtcccagc cggccacggg ggcggcctcg gcctcggcca
    18721 ccaggtcgtc aaagcttcgt gacatatcag aagtaatacc gcaaagagca tcaatagtct
    18781 ccagagattc ctggagggca ttcaccaccg gaggcactcg ttcccggtgg cgcacggcat
    18841 gggaacgggc ataccgcgaa cagacgtgcg tgtcgccgtg cggtgcggcg cgcaccccca
    18901 ccccccagcc ccgaggagtc gtgatggcct ggtatccggg cgccacgaag atggagctcc
    18961 agccggagtc ggacgaccag ccggcgatcc gtcccaccca gttcatcctg cacagcgtcg
    19021 gcgcgccgtg gaccgcgcgc cgcctctacg agttctggcg cgacagcacc aacctcgagt
    19081 cgcacttcgg cctcggctac ggaggcgacc tcgcgcagta catcggcacc cagacccgcg
    19141 ccgacgccaa ctaccgggcc aacctgcgcc cggacggcag cggtgcggtg agcatagaga
    19201 ccgcctccaa cctggagcac accgacccgt ggaccggccg gcaggtcgac agactcgtcg
    19261 aggtcggggt gtggctgcac cagtaccacg gcctgccgtt acgggtctgc cgctcctggg
    19321 acgaacccgg atacggctac caccgcctgt tcccgcagtg gtcctcgggc ggtacggcct
    19381 gcccgggcga cgcccgcgtg gggcagttcc acgacgtggt cttccccgcc atcgtggccc
    19441 gggcctccag caggcccgcc gacccgaagc cgggcggggc ggcgccgcgg acgctcggcg
    19501 agtacaccga cgcgcagacc gcgctcgtcc ccggcgcgtg gacgacgctc tcggtcaacg
    19561 gcgagaccct gatcagcggc gcgacggcgt acacggccac ggtcttcctg accgtgagcg
    19621 tcccggcggg cagtacgctc cagggccgct tctaccacca gcgggcggac ggctcccgct
    19681 ggaacggccc gatcgtcgag cgcatcgcga cggtgggcgc gtccttcgtc gacttcaccc
    19741 accacgggtc cgtctccgaa ggggagaccg tccgcttcga ggcgtgctac gacccgcccg
    19801 cgccgggcgt gcgcgacccg ggcacggtct ccacctcgcg ggcgcgcggc ttgtactgga
    19861 cctgacccgg cgtcgggagc cggttgcggt tgttctggtt cgggcttgcg gcgtcctggt
    19921 tcgggctcgc ggcgtctcgg gtcaggattg cggtgcctcg ggtcaggctt gcggcgtccc
    19981 ggttcgggct tgcggcgcct cgggtcaggc ctgcggttcc tcggttcggg cctgcggtgc
    20041 ctcgggtcag gcttgcggtg cctccggctc ggcgggctcg gcgatcagtg ccgtgcccgc
    20101 gcggcggaag ccggcccggg cgtagatccg ggccacgtcg tcgtcgccgg cggagaggaa
    20161 gacggtctcc gcgcccctcg accgcgcgtc ggcgacgagg gccgcggtga ccgcgagccc
    20221 caggccctgc cggcgcatgg cgggcagcgt cccgatgccg accagttcgg tgaccgcgcc
    20281 gacgggctgg tgcatgcccg aacacagggc cgtgtccccg cggacggccg cggcggccac
    20341 cgtcaggccc gcgcggatgc gcgcagccag gcggtccgcc gtgccgtccc gggcggcgcg
    20401 ccgctccgcc gccgccagtt cctcggtgcc cgtggtgccc accgcggtgc cgagctggga
    20461 gaaggcgagc gggccgaggg ccgccgcgct cggcagcgcg gggtcctccg ggccgagcag
    20521 ccgcacggcc aggccctcgg gcagcgccgg cacggccgtg gtgctgcccg gttcgagcac
    20581 catcaggggg tgctcgtgca cggtcagccc cgcctcctcg gcggccgccc gcagcgcggg
    20641 cgtcgtctcg gccacccact cgaagctttc cggaaggccg agttcgcgct ggcgggccag
    20701 gacccgcagc acgtcggcgg cggtcaccgg cccggcgcct gccgggcccc gggaggggcg
    20761 ggcgtagtac ggccagccgt ccccctcgcg gacgaacagg gtgagcgggc cgaagtcctc
    20821 ggcccgggcg gtgctgcgcg gcacgctgtc gtaatagccc tccagccggt cgagcagccc
    20881 ggggccggga aagtcggagg tctgtgcgga agagtcggca gagatca
//
