LOCUS       NZ_LNBE01000002        20609 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces roseifaciens strain MBT76 scaffold_2, whole genome
            shotgun sequence.
ACCESSION   NZ_LNBE01000002
VERSION     NZ_LNBE01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseifaciens
  ORGANISM  Streptomyces roseifaciens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1142035)
  AUTHORS   Wu,C., Zhu,H., van Wezel,G.P. and Choi,Y.H.
  TITLE     Metabolomics-guided analysis of isocoumarin production by
            Streptomyces species MBT76 and biotransformation of flavonoids and
            phenylpropanoids
  JOURNAL   Metabolomics 12, 90 (2016)
   PUBMED   27073352
REFERENCE   2  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     The complementarity of genome-mining and NMR metabolic-profiling
            facilitates lead-finding
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 1142035)
  AUTHORS   Wu,C., Du,C., Choi,Y.H. and Van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2015) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 1.2.06
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001445655.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:28:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,528
            CDSs (total)                      :: 7,450
            Genes (coding)                    :: 7,245
            CDSs (with protein)               :: 7,245
            Genes (RNA)                       :: 78
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 77 of 205
            Pseudo Genes (incomplete)         :: 168 of 205
            Pseudo Genes (internal stop)      :: 20 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:37:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28326
            Orig. end                         :: >48935
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LNBE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>20609
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>20609
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..>20609
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:>10609](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>10609
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    117..126
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            548..1192
                     /locus_tag="AS857_RS01990"
     CDS             548..1192
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638296.1"
                     /locus_tag="AS857_RS01990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine hydrolase"
                     /protein_id="WP_058041354.1"
                     /transl_table=11
                     /translation="MAPPDPPAERLDPATTVLLTVECQRGVVGPDSALPELAAAARASG
                     ALVNIARLVAGAHDAGVQVVHAVAERRPDGRGASRNARLFRAAERLPVQQLTGTRAVRV
                     ADPIPVGDADLVVRRLHGLSPLAGTGVDALLRNLGCRTLVVTGVSANVAVPNTVFDAVN
                     LGYTAVVPADAIAGVPADYTAAMVSHTLALVATVTTTEAVLRGWRSTPRSG"
     gene            complement(1215..1724)
                     /locus_tag="AS857_RS01995"
     CDS             complement(1215..1724)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988822.1"
                     /locus_tag="AS857_RS01995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske (2Fe-2S) protein"
                     /protein_id="WP_079109998.1"
                     /transl_table=11
                     /translation="MNHTSRTASTDSADSAGSPGSGEPSVSPAPRGSTRRSVVAAAGAA
                     GLVTVLAACGGGGDGGKDEGGDGKGDGKGDGELAKAADIPEGGGKVFPDRKVVVTQPVK
                     GEFKAFSAVCTHQGCVVKDVSGGTINCPCHGSRFRIVDGSVQGGPAQGPLPEEQVSVRG
                     GSLHLG"
     gene            1820..2644
                     /locus_tag="AS857_RS02000"
     CDS             1820..2644
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058589.1"
                     /locus_tag="AS857_RS02000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HipA family kinase"
                     /protein_id="WP_058041355.1"
                     /transl_table=11
                     /translation="MLPEVTATRYVTPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKT
                     LVAEVVCGQLGRALGLRVPDLAAIQLDPVIGRGEPDQEVQGLLKASGGLNLAMDFLPGA
                     LGFDPLAFEVGAAEAGRVIWFDALINNVDRSWRNPNLLVWHGELWLIDHGATMIWHHNW
                     PGAAAAAGKAYDASDHVLATFGPDLAAAAAELAPRVTEELLTEVAADVPDEWLADEPGF
                     DGPDAVRRAYVEVLLERARSIGDRIAVGERSKDKPSQAPEWVRVRLDGRAGK"
     gene            2641..3036
                     /locus_tag="AS857_RS02005"
     CDS             2641..3036
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181330.1"
                     /locus_tag="AS857_RS02005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3037 domain-containing protein"
                     /protein_id="WP_058041356.1"
                     /transl_table=11
                     /translation="MTGRHNGREVFEYALLRVVPRVERGEQINAGVVVYCQAKGYVAAR
                     VHLDEARLLALDPTADVAGVRAALCAVEGVCLGGERAGQAAGDDPGRRFRWLIAPRSTV
                     VQPGPVHAGLTADPESEPERLLDLLVR"
     misc_feature    complement(3149..3158)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            3178..3939
                     /gene="fabG"
                     /locus_tag="AS857_RS02010"
     CDS             3178..3939
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-170). E-value: 5.2e-21. Score:
                     67.3. Matches aSDomain:
                     nrpspksdomains_AS857_RS02010_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262869.1"
                     /locus_tag="AS857_RS02010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_058041357.1"
                     /sec_met_domain="adh_short (E-value: 6.1e-38, bitscore:
                     126.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKPEQRVAVVTGAARGIGAVTAVRLAREGRAVAVLDLDEEACAG
                     TVEQITAAGGRALAVGCDVSDADRVDAAVTRIAAELGAPLILVNNAGVTRDNLLFKMSE
                     SDWDTVMSVHLRGAFLMSRACQKHMVDARFGRIVNLSSSSALGNRGQANYAAAKAGVQG
                     LTKSLAKELGKFGITANSVAPGFIATEMTAATAARLGMTFEDFKAAAATQIPVERVGEP
                     EDIANAVAFFTGEEAGFVSGQVLYVAGGPLN"
     aSDomain        3199..3687
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS02010_PKS_KR.1"
                     /evalue="5.20E-21"
                     /label="AS857_RS02010_PKS_KR.1"
                     /locus_tag="AS857_RS02010"
                     /protein_end="170"
                     /protein_start="7"
                     /score="67.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGIGAVTAVRLAREGRAVAVLDLDEEACAGTVEQITA
                     AGGRALAVGCDVSDADRVDAAVTRIAAELGAPLILVNNAGVTRDNLLFKMSESDWDTVM
                     SVHLRGAFLMSRACQKHMVDARFGRIVNLSSSSALGNRGQANYAAAKAGVQGLTKSLAK
                     "
     CDS_motif       3205..3273
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AS857_RS02010_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="AS857_RS02010"
                     /protein_end="32"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="VVTGAARGIGAVTAVRLAREGRA"
     CDS_motif       3664..3774
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AS857_RS02010_0002"
                     /evalue="2.10E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="AS857_RS02010"
                     /protein_end="199"
                     /protein_start="162"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="GLTKSLAKELGKFGITANSVAPGFIATEMTAATAARL"
     gene            3954..4748
                     /locus_tag="AS857_RS02015"
     CDS             3954..4748
                     /NRPS_PKS="Domain: PKS_KR (22-184). E-value: 7.1e-09.
                     Score: 27.8. Matches aSDomain:
                     nrpspksdomains_AS857_RS02015_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522743.1"
                     /locus_tag="AS857_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_058041358.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1.2e-32, bitscore:
                     109.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQQQEQQEQQEQAGRRDTGKVALVTGASRGIGYGIAQALVARG
                     DRVVITGRNEDALKQAVESLGAGRAIGIAGKAHDEAHQVSAVQHAMEEFGRIDYLVNNA
                     GTNPVFGPMAELDLGVARKVFETNVISALGFAQQTWRAWQKDNGGAIVNIASVAGISAS
                     PFVGAYGMSKAAMVNLTLQLAHEFAPAVRVNSIAPAVVKTKFAAALYEGREEEVVASYP
                     LGRLGVPEDIGGAAAFLLSDAAGWITGQTLVVDGGIFLNAGF"
     aSDomain        4020..4505
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AS857_RS02015_PKS_KR.1"
                     /evalue="7.10E-09"
                     /label="AS857_RS02015_PKS_KR.1"
                     /locus_tag="AS857_RS02015"
                     /protein_end="184"
                     /protein_start="22"
                     /score="27.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGASRGIGYGIAQALVARGDRVVITGRNEDALKQAVESLGA
                     GRAIGIAGKAHDEAHQVSAVQHAMEEFGRIDYLVNNAGTNPVFGPMAELDLGVARKVFE
                     TNVISALGFAQQTWRAWQKDNGGAIVNIASVAGISASPFVGAYGMSKAAMVNLTLQLA"
     CDS_motif       4026..4115
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AS857_RS02015_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="AS857_RS02015"
                     /protein_end="54"
                     /protein_start="24"
                     /score="17.9"
                     /tool="antismash"
                     /translation="LVTGASRGIGYGIAQALVARGDRVVITGRN"
     gene            4849..5547
                     /locus_tag="AS857_RS02020"
     CDS             4849..5547
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123495.1"
                     /locus_tag="AS857_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_058041359.1"
                     /transl_table=11
                     /translation="MTVTDVLPQSWHGVLAEELDKPYFKELTDFVEEERTKAPVYPPRG
                     EVFAALDATPYDQVKVLILGQDPYHGAGQGHGLCFSVRPGVKTPPSLRNIYKEMREELG
                     YDVPDNGYLQPWAEQGVLLLNAVLTVRGGEPNSHKGKGWEKFTDAVIRAVASRPDPAVF
                     VLWGNYAQKKLPLIDESRHVVVKGAHPSPLSAKKFFGSRPFSQINEAVAAQGHEPIDWR
                     IPDLAAVPAL"
     gene            complement(5616..6320)
                     /locus_tag="AS857_RS02025"
     CDS             complement(5616..6320)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AS857_RS02025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_144440695.1"
                     /transl_table=11
                     /translation="MHRLPAVTVMAAAVALAAAGCVSVSQPPASHSPPRPPGHSRAGDL
                     LPGPAREDLITTGPDGARSPTAPGQDPRAATAGGASGPEGAITPSGRSGAHGHRDGADP
                     ADPYDFGDPPDASDDGAEPSRSSGSPRLSHPPRRAGRTWASPDRPASPDLGPSYPRSEA
                     PAPQPEQRTADSPPASASHREASSAAPPPQAPPPAPAPRARNNNVCAMGRQHGRWQQGG
                     DASRICDSVYGH"
     misc_feature    complement(6363..6379)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.77"
                     /tool="antismash"
     gene            complement(6399..6908)
                     /locus_tag="AS857_RS02030"
     CDS             complement(6399..6908)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123498.1"
                     /locus_tag="AS857_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /protein_id="WP_058041361.1"
                     /transl_table=11
                     /translation="MIIPERPTPPTISDERTSLESWLDFHRATLALKCAGLDEAQLREA
                     SAPPSPMSLMGLVRHMADVERSWFRRCLAREDAGPIFYTDEEPDRDMEVTETDSWEEAY
                     ATWQAEIAAAREVARGRSLDDRGFAPHRNKEFDLRWIYVHMIEEYARHNGHADLIRERI
                     DGATGA"
     gene            7016..7921
                     /locus_tag="AS857_RS02035"
     CDS             7016..7921
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884557.1"
                     /locus_tag="AS857_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_058041362.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 8.3e-18, bitscore:
                     61.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGCIGLGDIAQKAYLPVLATRPGLELHLHTRTPATLARVAEAH
                     RIPDAQCHTGLDALLAADLDAAFVHAATAAHPELVTRLLEAGVPVYVDKPLAYDLATSE
                     RLVRLARERGVSLMVGFNRRYAPSYTQCLDHPRDLILMQKNRVGLAEDPRTLVLDDFIH
                     VVDTLRFLAPGPVEHVDVRARVREGLMHHVVLQLSGAGFTAIGTMNRMSGSTEEILEVS
                     GQDTKRQVLNLSEVIDHKGQPSVRRRGDWVSVSRQRGIEQTVLAFLDAVRAGKLLDAED
                     ALATHELCERIVKAASEQAS"
     gene            complement(7893..9461)
                     /gene="lnt"
                     /locus_tag="AS857_RS02040"
     CDS             complement(7893..9461)
                     /EC_number="2.3.1.269"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016410 - N-acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006497 - protein lipidation [Evidence
                     IEA]"
                     /GO_process="GO:0042158 - lipoprotein biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lnt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607227.1"
                     /locus_tag="AS857_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="apolipoprotein N-acyltransferase"
                     /protein_id="WP_058041363.1"
                     /transl_table=11
                     /translation="MTTQPPDGPYAGLPTRPWPRAAAAVVAGALPALTFPTPSLWWLAY
                     VALVPWLSLIRTAPSARRAALDGWLGGGGFLLAVHHWLLPSLHVFILVLAALLGLLWAP
                     WGVLVKRLLGGSPGPARAAAALLAVPSGWLMVELARSWEYLGGPWGLFGASQWQVQPAL
                     KLASTGGIWLVSFLLVAINTAVSTVIWASRARITGLIGLAGCAAVVAGVWMWVPSPRSA
                     GTVRIALVQPGVVDGTGSVQHRFDRQEELTRKLAGQRVDLVVWGESGVGGDLAQHPGLR
                     DRLTALSREVGADLLVNVDARRSDRPGIFKSSVLVGPGGPTGGRYDKMRLVPFGEYVPA
                     RSLLGWATSVGKAAGEDRMRGEHPVVMRLPASPSVPEGLRIGPLVCFESAFPDMSRQLP
                     RDGAQVIVAQSSTSTFQHSWAPWQHASLASLRAAETWRPVVHATLTGVSTVAGPQGRAV
                     GAPLGTDRSEAVVREVPLARGTSPYVRYGDWVVLASLAVIACTCAAEGVRLVRRNVRKP
                     APKRP"
     misc_feature    9761..9772
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            10001..>10609
                     /locus_tag="AS857_RS40905"
                     /pseudo=""
     CDS             10001..>10609
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="AS857_RS40905"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="T1TS (E-value: 1.5e-42, bitscore: 142.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYGQSGPLTVVAKLHAVLFSLDDALCDESTATAHGLAHTTSRIM
                     RVLEAPVPEWPDDSPHAAALRAVRLELAEHATPSQLRHWTEGMRTYLTGLVWEAACRRD
                     RALPSVNDYATMWMRAIGMAPSTALMDIAGGYELDDRDLDRPEVRALTEMTWTLVAWDN
                     DFYSRNKEIRRAGDNLNLIDVLAQERDWEPARAQEEAMAM"
     gene            complement(10873..12321)
                     /locus_tag="AS857_RS02045"
     CDS             complement(10873..12321)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031759.1"
                     /locus_tag="AS857_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_058041364.1"
                     /transl_table=11
                     /translation="MTLPSERPRTTSPAGPPPQCPAHATGPGGITRLYGPEAEADPMGL
                     YERLRQKHGQVAPVLLHDDVPAWLVLGYRENLDVARTPSRFSRDSRRWIEAREGRVAPT
                     HPLAPITTWQPICVFADGQQHERWRGAVNDSIARFDKRGIRRHVTQYSNQLVDRFCASG
                     RADLVHEFAEQLPMMAMTQLLGMPEAYSPQLVNAARDMIKGTETAIASNEFVQETLRKL
                     VARKHVEPGADFTSWLLEHPAGLSDDEVQQHLRLVLIAAFETTANLIANTLKMVLTDHR
                     FQASLAGGHMTLPDAVEQVLWDEPPFISILGRWATQDTELAGQQIKEGDALILGLAAAN
                     MDTVIRPDPDVPVHGNRSHLAFSGGQHECPGQDVGRAIADTGIDALLLRLPDLTLAVDE
                     SELTYRSTLMSRHLTGLPVRFTARAPLPPEETLTPAPEPPLPAQPERAEQPAIPAPPVR
                     AAGPETPGSRRSWWRSLRRLLGRR"
     gene            complement(12318..12956)
                     /locus_tag="AS857_RS02050"
     CDS             complement(12318..12956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056720.1"
                     /locus_tag="AS857_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_058041365.1"
                     /transl_table=11
                     /translation="MDYRSSDSPGLETYAGPRSEDVLPASATAAVKVVIVGGFGVGKTT
                     LVGSVSEIRPLTTEETMTQAGVGVDDIAGIEHKTETTVAMDFGRISINEHLVLYLFGTP
                     GQERFWFLWNGLFEGALGAVVLLDTRRMDVSYDVIGRLEEKGVPFVVGVNRFPQAPRYP
                     MEQLRSAMDLDDSVPMIDCDARDRASCRDTLLTLMRYLYTLTTASTEHQ"
     gene            complement(12937..13302)
                     /locus_tag="AS857_RS02055"
     CDS             complement(12937..13302)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712910.1"
                     /locus_tag="AS857_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_058041366.1"
                     /transl_table=11
                     /translation="MSTEGPGSPTAPGSPDRLYILTGGEPRAERKTELDLVTLIVSRSE
                     ADPGLQPEHAAIVRMCAYPLSVAEISAYLELPVSTLTLLLTELVAGRHVEARPPVPAAA
                     LPDVQLLEAVMNGLQKL"
     gene            complement(13299..13706)
                     /locus_tag="AS857_RS02060"
     CDS             complement(13299..13706)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056718.1"
                     /locus_tag="AS857_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_058041367.1"
                     /transl_table=11
                     /translation="MTQPRFNMDWMLKDLATSVPQTRHVIVLSSDGLRMAQHGTDPDAA
                     DRLAAACAGLQSLSTAIAGEFPHGDGQMRLVVIEVDGGFFYLMAAGAGAFLAVLADDDV
                     DAELMGMRMRDLVARIGSHLTSPPRVGGSVT"
     gene            complement(13711..15225)
                     /locus_tag="AS857_RS02065"
     CDS             complement(13711..15225)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181448.1"
                     /locus_tag="AS857_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_058041368.1"
                     /transl_table=11
                     /translation="MVGTGSSVQRRPVSALIWLISPLVLAVCTGTAVLAVAPDARVPVA
                     WCGASATVAVALASSEAARRGRVIAALRRRCTEQEAGLRYQLDQHEAETRRLAKELLPR
                     AIHLLQRGAPTEVVLRHTLPVHDLEPGYAAAHRSVLKSVIEAVQAEEGLRDSAQRAFVN
                     IARRMQAIVHQQAYDIREMEHKHGNDPDVFGDLLHLDHGNALTGRLADSIAVLGGSRPG
                     RQWKNEIPLYNVLRGAMSRILEYRRVDLHSVADVAVVGAGVEPVIHALAELLDNATRYS
                     PPQTRVHLTAVDIQSGIAVEIEDAGVGLTDEARRRTDRVLSREGALDLDDLGEAPRLGL
                     AVVSRLARTYNFLVSLRPSAYGGVRAVLVIPMDLITASKHPGGDIARAPKLPPFKSKRR
                     PGQKIPPPAPQTAPPMMEHPIPPPLGDSGLPQRRRRRGPAPLPFGRGAAERRDRPPAPP
                     AAPAAPEEAPKQPGMWLAAFNRGINGESLEPDAGRSHSDIPSDKEE"
     misc_feature    complement(15478..15492)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.63"
                     /tool="antismash"
     misc_feature    15484..15499
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(15485..15498)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.78"
                     /tool="antismash"
     gene            15653..18367
                     /locus_tag="AS857_RS02070"
     CDS             15653..18367
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954293.1"
                     /locus_tag="AS857_RS02070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_058041369.1"
                     /transl_table=11
                     /translation="MSGHQREQNASAALFERELELQAAEQAVQRLCGTATEGRSRLGGL
                     LLYSGEAGLGKTALLTKTRRMAIEAGKCTVLFARGSESAQPVPFHVVRQLLQPVLAPMS
                     EAERKEMLGGWYEIAGPALGIAPPVGPQDPQGVRDGIDWLVTQLATRQEPVVLMIDDAH
                     WADAESLAWLSFFAVRLQETPLLAVIAYRPEELAENAPGFSELVTGRSSRPVELRALTP
                     EAVNRLVHGSFPDQADAPFCREVWAVTGGNPYETVELVAKAQDRGLKPVEESASLLRDL
                     GATARGSGLVSRLERLGTAVTRFAWAAAVLGTEIQPSLAANLAGMGPAQAAECADKLRH
                     ARILTGAIDLEFVHPLIATAIYASIPPATRTAMHGQAAWSVTEAGLGPAAASRHLLEVH
                     PDHDSELVEQLRVAAREHLAVGAPDAARRCLERALQEPPPEEERASVLYELGCSALLTS
                     PSTTVNHLKTALSLPHLTEELRVDATYRLSQAYAHNSQLREAAEVVKEQAERTPPGAGR
                     MRLQAAHYLWQGIQVEEQDSLGRSRRIAELAERIRGRDNTERTLLALRGFDGMIRGEDA
                     VQVVEHIERALVDGRLAEGMGWTNTEWGFEVPSIIGITFAYTDRLDHAEELFKDAVRAF
                     EISGWSGGHLAFAHDFLGLVHRRRGELDEAEALLREGLRLGKRLGPGLPIHWDGACLLI
                     DTLLARGRVDEAQAFAEENGFQAPYTPAIVLPDAACLAGRLLLAQGRRKEAVTELETAG
                     RRLEERGRNNTVWAPWALDLAVAVKDEEPERARALADKAVRNAARFGTDTAIGDALRRA
                     AIVAEPDEALVKLGQAVVHLRRSPCRYEFAAALVAHGSALLRADRPAEATERLREGLEV
                     AQQCAADGLVATARADLASAVCDGVEPAGDAVR"
     gene            complement(18401..19411)
                     /locus_tag="AS857_RS02075"
     CDS             complement(18401..19411)
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008738109.1"
                     /locus_tag="AS857_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ku protein"
                     /protein_id="WP_245699552.1"
                     /transl_table=11
                     /translation="MWKGAIGFGLVSVPVRLYAATQEHGLRLHQVHDADGGRIHLKRIC
                     EACGEPVDYEHIAKGFQDDEGHTAVVTQDELAGLPLPSKKLIDVLAFVDADRIDPLQLS
                     NGYYLAPESAAADKPYVLLRETLKQTERVAVTKIALRTRESLALLRVHGDLLTLHTMYW
                     PDEIRDSGDLAPPSSVTVRPQELKMATSLMDTLSEEFDLDELEDEYEIALSELINAHLS
                     DRPVPKKETAPAPDNVIDLMAALQASIDKAAGKTGEETEKGTKREAAPRKSTRSTAKKS
                     AAPQKRTAAKKTAAASSTAKGKKTATSTAKPGTAKSATAKTAKKTATGKSGRRAS"
     gene            19453..20358
                     /gene="ligD"
                     /locus_tag="AS857_RS02080"
     CDS             19453..20358
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954288.1"
                     /locus_tag="AS857_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_058041371.1"
                     /transl_table=11
                     /translation="MSVSPERQAVEIEGHRLALTHLDRVLFPASGHTKAQVLQYYARIA
                     PVMVAHTADRPASFVRAPEGPGGQSWVAKNPPGGKPRWVRVVPVEHREGVTEQVVIDTT
                     AALVAMANLGAYEVHVPQWTVTAGPDGHDRLVLDLDPGPGADLVVCCRVAQRLRQLLDD
                     DGLTAHAVVSGSKGLHLYAPVHAASGRAAGGYAKALAARMMGEHPGLVVVSMARVERRG
                     KVLIDWSQNASAKTTAAPYTVRLREGVPGVAAPVTWDEVAACRDPEELAFTPEQVLDRA
                     ETYGDLLAPLTGDATRAQLP"
ORIGIN
        1 gcgtggcggc cgtcgtgcgg catcgagggc aggccgccga agtacttggt ggtgaacagg
       61 gcctccggcg cggcgagctc cgggcagggt tcgcccgtgc gcggggcctc gccgacgaag
      121 gcggccgtgc ccgacagctc cgctccgcgc agctccccgt actcccgccc gtcgtccacg
      181 agcaccgcga tccgggcgtc gcgccgcagc tccgcccacc ggcggctgcg gacgatcgag
      241 tacagccaca ccgcggatcc gtcccagacg aaccacagtg cgctcaggtg cggacgcccg
      301 tcccgtccca ccgtggccac ccggcaggtg cgctgcccgg cgaggaacgc gtccagctcc
      361 ggccgcgtca tcatgatccg gcggccccgc cgctgggtgg tgaccatgcc cgcgccctcc
      421 ccgcaccccg ctgtctgact gagtgtcagg aagtgtggac cccttccccc gccggcgcaa
      481 tgcccgctac cctcacgcgg cccggtcctc acccgccgga caccggcccc aggagggagc
      541 gaccagcatg gcgccgccgg acccgcccgc cgagcgcctc gaccccgcga cgaccgtgct
      601 gctcaccgtc gagtgccagc gcggcgtcgt aggccccgac agcgccctgc ccgagctcgc
      661 ggccgccgcc cgcgcctccg gcgccctcgt gaacatcgcc cgcctggtcg cgggcgcgca
      721 cgacgcgggc gtccaggtcg tgcacgccgt cgccgagcgc cgccccgacg gccgcggcgc
      781 cagccgcaac gcccgcctct tccgcgcggc cgagcggctg cccgtgcagc agctgaccgg
      841 cacccgcgcg gtccgcgtcg ccgacccgat cccggtcggc gacgcggacc tggtcgtccg
      901 gcggctgcac gggctctcgc ccctggcggg cacgggcgtg gacgccctcc tgcgcaacct
      961 cggctgccgc accctcgtcg tcaccggcgt ctcggccaac gtggccgtgc ccaacaccgt
     1021 cttcgacgcc gtcaacctcg gctacacggc cgtcgtcccc gccgacgcca tcgccggcgt
     1081 gcccgcggac tacaccgcgg ccatggtcag ccacaccctg gcgctcgtcg ccaccgtcac
     1141 cacgaccgag gccgtcctgc gcggctggcg gagcacgccc cggagcggct gacgccgggc
     1201 tgcggcgccc gggctcaccc caggtgcagc gagccgccgc ggaccgagac ctgctcctcg
     1261 gggagcggcc cctgcgccgg accgccctgc acgctcccgt ccacgatccg gaacctgctg
     1321 ccgtggcacg ggcagttgat ggtgcccccg gagacgtcct tgaccacgca cccctggtgg
     1381 gtgcagaccg ccgagaaggc cttgaactcg cccttcaccg gctgggtcac cacgaccttc
     1441 cggtccggga agaccttgcc gccgccctcg gggatgtccg cggccttcgc gagctccccg
     1501 tcaccctttc cgtccccctt cccgtccccg ccctcgtcct tgccgccgtc gccccctccg
     1561 ccgcacgcgg cgagcacggt gacgagaccg gcggcccccg ccgccgcgac gacgctgcgg
     1621 cgggtcgagc cgcgcggggc cggggagacg gagggctcac cggaacccgg ggatccggcg
     1681 gagtctgccg agtcggtgga agcggtccgt gacgtgtggt tcatgttcgc tcctctgaac
     1741 gtgcaggttc agggagacgt acggagccgg cggcccccgc gttcaaaggg cggcagaagt
     1801 cccgcagtag cctggggcaa tgctccccga agtcacagcc acccgatacg tcacgccctt
     1861 gcgtgagggc ggctcgctcc ccggcatcgt cgaggccgac gatctgggta cgtacgtcat
     1921 gaaattcacc ggtgcgggtc agggccgcaa gacgctggtc gccgaggtcg tctgcggaca
     1981 gctcggccgc gccctcggcc tgcgcgtccc ggacctggca gccatccagc tcgacccggt
     2041 catcggccgg ggcgagccgg accaggaggt gcaagggctg ctcaaggcca gcggcgggct
     2101 caacctcgcc atggacttcc tgcccggcgc gctcggcttc gacccgctcg ccttcgaggt
     2161 cggggcggcc gaggccggcc gcgtgatctg gttcgacgcg ctcatcaaca acgtcgaccg
     2221 ctcctggcgc aaccccaacc tgctcgtgtg gcacggcgag ctgtggctca tcgaccacgg
     2281 cgccaccatg atctggcacc acaactggcc gggggccgcc gcggccgcgg gcaaggccta
     2341 cgacgcctcc gaccacgtcc tcgccacctt cggcccggac ctcgcagcgg ccgcggccga
     2401 gctcgctccg cgcgtcaccg aggagctgct gaccgaggtc gccgccgacg tgcccgacga
     2461 gtggctcgcg gacgagccgg gcttcgacgg ccccgacgcg gtgcgccggg cctacgtcga
     2521 ggtgctgctg gagcgggcac ggagcatcgg cgaccggatc gcggtcggcg aacgcagcaa
     2581 ggacaagccc tcgcaggcgc cggagtgggt gcgtgtcagg ctcgacggaa gggccgggaa
     2641 gtgaccgggc gccacaacgg acgcgaagtt ttcgagtacg cactgctgcg ggtcgtcccc
     2701 cgcgtcgagc gcggtgagca gatcaacgcc ggggtcgtcg tctactgcca ggccaagggc
     2761 tacgtcgccg cccgcgtcca cctggacgag gcgcggctgc tggccctcga cccgacggcg
     2821 gacgtggcgg gcgtgcgcgc cgcgctctgt gccgtcgagg gcgtctgcct cggcggggag
     2881 cgtgccggac aggccgccgg ggacgacccg gggcgccgct tccgctggct gatcgctccc
     2941 cgcagtacgg tcgtgcagcc gggccccgtg cacgccggcc tgacggcgga tccggagagc
     3001 gagccggagc ggctgctgga cctgctggtg aggtgaggtg cagggcggcg cgggaaggcg
     3061 ttgacagcgg gtggcggggc ttctagcgtc tgacccgccg aagctactaa gcggttgctc
     3121 acctgcccgg ccgggtgccg ggcgggcggg ccgccttcga ggtgaggaga tccccgtatg
     3181 cccaagcccg agcagcgcgt ggccgtcgtc acgggcgcgg cccgcggcat cggtgccgtg
     3241 accgccgtcc gcctggcccg ggagggccgc gcggtcgccg tcctggacct cgacgaggag
     3301 gcctgcgcgg gcaccgtcga gcagatcacc gcggccggcg gccgggccct cgccgtcggc
     3361 tgcgacgtct ccgacgccga ccgggtggac gccgccgtca cccggatcgc cgccgagctg
     3421 ggcgcgccgc tcatcctcgt caacaacgcg ggcgtgaccc gtgacaatct gctgttcaag
     3481 atgagcgaga gcgactggga caccgtcatg agcgtgcacc tgcggggcgc gttcctgatg
     3541 tcgcgcgcct gccagaagca catggtcgac gcgcgcttcg gccgcatagt caacctctcc
     3601 agcagctccg ccctcggcaa tcgcggccag gccaactacg ccgccgccaa ggccggcgtg
     3661 cagggcctga ccaagtcgct cgccaaggag ctcggcaagt tcggcatcac cgccaactcc
     3721 gtcgcccccg gcttcatcgc caccgagatg acggccgcca ccgcggcccg cctcggcatg
     3781 accttcgagg acttcaaggc cgccgcggcg acccagatcc cggtggagcg cgtgggcgag
     3841 cccgaggaca tcgccaacgc ggtcgccttc ttcaccggcg aggaggcggg cttcgtctcg
     3901 ggacaggtcc tgtacgtggc cggcggaccg ctcaactgac aggaagcacg gagatgactg
     3961 cacagcagca ggagcagcag gagcagcagg agcaggccgg ccgccgggac accggcaagg
     4021 tcgccctcgt caccggagcg agccgcggca tcggttacgg catcgcgcag gcgctcgtcg
     4081 cccgcggcga ccgcgtcgtg atcaccggcc gcaacgagga cgccctcaag caggccgtcg
     4141 agtcgctcgg cgcgggccgg gcgatcggca tcgcgggcaa ggcccacgac gaggcccacc
     4201 aggtctccgc cgtgcagcac gccatggagg agttcggccg catcgactac ctggtcaaca
     4261 acgccgggac gaaccccgtg ttcggcccca tggccgagct cgacctcggc gtcgcccgca
     4321 aggtcttcga gaccaacgtg atctccgccc tcggcttcgc gcagcagacg tggcgggcgt
     4381 ggcagaagga caacggcggc gcgatcgtca acatcgcgtc ggtcgccggc atctccgcct
     4441 cccccttcgt cggggcctac ggcatgagca aggccgcgat ggtcaacctc acgctgcagc
     4501 tcgcgcacga gttcgccccg gcggtgcggg tcaactccat cgcaccggcc gtcgtcaaga
     4561 cgaagttcgc cgccgccctc tacgaggggc gcgaggagga ggtcgtggcc tcgtacccgc
     4621 tcggccgcct cggcgtgccc gaggacatcg ggggagcggc cgcgttcctg ctctcggacg
     4681 cggccgggtg gatcaccggg cagaccctcg tcgtggacgg cgggatcttc ctgaacgcgg
     4741 ggttctgagg gcgggcggca ccgggcgccg ggggcgggcg tcggccgttg tcagtggtcg
     4801 ccggtaagtt ctcacccgag aacggaacga accccggagg ttgttgacgt gaccgtcacc
     4861 gacgtgctgc cccagtcctg gcacggtgtc ctcgccgagg agctggacaa gccctacttc
     4921 aaggagctca ccgacttcgt ggaggaggag cgcacgaagg caccggtgta cccgccgcgc
     4981 ggggaggtct tcgcagccct ggacgcgacc ccgtacgacc aggtcaaggt cctcatcctc
     5041 ggccaggacc cctaccacgg cgcgggccag ggccacggcc tgtgcttctc ggtccgcccc
     5101 ggggtgaaga ccccgccctc cctgcgcaac atctacaagg agatgcgcga ggagctcggc
     5161 tacgacgtcc cggacaacgg ctacctccag ccgtgggccg agcagggcgt cctgctgctc
     5221 aacgccgtgc tgacggtccg cggcggtgag cccaattccc acaagggcaa gggctgggag
     5281 aagttcaccg acgcggtcat ccgcgccgtg gcgtcccggc ccgacccggc cgtcttcgtc
     5341 ctctggggca actacgccca gaagaagctg cccctgatcg acgagagtcg gcacgtcgtg
     5401 gtcaagggcg cccacccctc gccgctgtcg gcgaagaagt tcttcggcag ccgccccttc
     5461 agccagatca acgaggcggt cgcggcccag ggccacgagc cgatcgactg gcgcatcccg
     5521 gacctggcgg ccgtgccggc cctctgatcc ggtcccggcc ggggcccgcg ggcgggcatc
     5581 gtgcccgccg gccccggccg cactgcggcg gtgcgtcagt gcccgtagac cgagtcgcag
     5641 atccgtgagg cgtcgccgcc ctgctgccag cgcccgtgct gccggcccat cgcgcagacg
     5701 ttgttgttac gggcccgggg cgcgggcgcc ggcggtggtg cctgcggggg cggcgccgcg
     5761 gacgacgctt cccggtggga ggccgatgcg ggcggggagt ccgcggtgcg ctgctccggc
     5821 tgcggggcgg gcgcctcgct ccgcgggtag gacgggccga ggtccgggga tgcgggccgg
     5881 tccggcgagg cccaggtgcg gcccgccctg cggggcgggt gcgagagccg cggggagccg
     5941 gaggagcgtg acggctccgc tccgtcgtcg gaggcgtccg ggggatcgcc gaagtcgtaa
     6001 ggatccgcag gatccgcccc gtcccggtgg ccgtgggcgc cggagcggcc ggaaggggtg
     6061 atcgcgccct cgggtcccga ggcgcccccg gccgtggcgg ctctcgggtc ctgcccggga
     6121 gccgtggggg agcgcgctcc gtcgggcccc gtggtgatca gatcctcacg ggcggggccg
     6181 ggcagcagat cgcccgcccg ggagtggccc ggcgggcggg gcggggagtg ggaggcgggc
     6241 ggctgggaga cggacacaca cccggcggcc gccagcgcca ccgccgccgc catgaccgtc
     6301 actgcaggca gtcgatgcac tcgctcaact ctgctgtgcg gccgtcggcc ttgggaatta
     6361 cccgcacggg tgatgtgcga tcatgcgtcc gggagcgctc aggccccggt cgccccgtcg
     6421 atccgctcgc ggatgaggtc ggcgtggccg ttgtggcgcg catactcctc gatcatgtgg
     6481 acgtagatcc accgcaggtc gaactccttg ttgcggtgcg gggcgaagcc gcggtcgtcc
     6541 agcgagcgcc cgcgcgccac ctcccgggcc gcggcgatct ccgcctgcca ggtggcgtag
     6601 gcctcctccc agctgtccgt ctccgtgacc tccatgtccc ggtccggctc ctcgtcggtg
     6661 tagaagatcg gcccggcgtc ctcgcgggcc aggcaccggc ggaaccagct gcgctcgacg
     6721 tcggccatgt gccggacgag acccatgagg ctcatcgggg acggcggcgc cgaggcctcg
     6781 cgcagctgtg cttcgtccag gcccgcacac ttcagggcca gcgtggcacg gtggaagtcg
     6841 agccagctct ccagactggt gcgctcgtcg gagatcgtgg ggggcgtggg acgctcagga
     6901 atgatcatgg cggtcatcct cgcgcccccg tgccgcccgc gccagaggtt ttcgccggtg
     6961 cccttccgta cagccgtatg cttcccaaac gaaggcacgt atccagggag gcgctgtgaa
     7021 ggtcggctgc atcggactcg gagacatcgc acagaaggcg taccttccgg tacttgccac
     7081 ccggccgggt ctcgaactcc acctccacac ccgcaccccc gccacgctcg cgcgcgtcgc
     7141 cgaggcacac cgcatcccgg acgcccagtg ccacaccggc ctcgacgcgc tgctcgccgc
     7201 ggacctcgac gcggccttcg tccacgcggc gaccgcggcc caccccgagc tcgtcacccg
     7261 cctcctcgaa gcgggcgtgc cggtctacgt cgacaagccc ctcgcctacg acctcgccac
     7321 cagcgagcgg ctcgtccgcc tcgcccggga gcggggcgtg agcctgatgg tcggcttcaa
     7381 ccgccgctac gcgccgtcct acacccagtg cctggaccac ccgcgcgacc tcatcctgat
     7441 gcagaagaac cgcgtcgggc tggccgagga cccgcgcacc ctcgtgctcg acgacttcat
     7501 ccacgtcgtc gacaccctgc gcttcctcgc cccggggccc gtcgagcacg tggacgtgcg
     7561 cgcccgggtc cgcgagggcc tcatgcacca cgtcgtactc cagctctccg gcgccggctt
     7621 cacggccatc ggcaccatga accggatgag cggctccacc gaggagatcc tcgaggtctc
     7681 cggacaggac accaagcggc aggtcctcaa cctctccgag gtgatcgacc acaaggggca
     7741 gcccagcgtc cgcaggcgcg gcgactgggt gtccgtctcc cgtcagcgcg gcatcgagca
     7801 gaccgtcctc gccttcctcg acgcggtccg ggcgggcaag ctgctcgacg ccgaggacgc
     7861 gctggccacc cacgaactgt gcgagcgcat cgtcaaggcc gcttcggagc aggcttcctg
     7921 acgttccgtc gcaccagccg gacgccctcg gcggcgcacg tgcaggcgat caccgccagg
     7981 gacgccagga cgacccagtc cccgtaccgg acgtaggggc tcgtgccgcg ggccagtggc
     8041 acctcgcgga cgacggcctc gctgcggtcg gtgccgagcg gtgcgccgac cgcccggccc
     8101 tgcgggccgg cgaccgtgct cacgcccgtc agcgtcgcgt gcaccaccgg ccgccaggtc
     8161 tcggccgccc gcagcgaggc gagcgaggca tgctgccacg gggcccagct gtgctggaac
     8221 gtggaggtgg aggactgcgc gacgatcacc tgggcgccgt cgcggggcag ctgccggctc
     8281 atgtcgggga aggccgactc gaagcacacc agcgggccga tccgcaggcc ctccggcacg
     8341 gagggagagg cgggcagccg catcaccacc gggtgttcgc cgcgcatgcg gtcctcgccg
     8401 gccgccttgc ccaccgacgt ggcccagccg agcagggagc gcgccggcac gtactccccg
     8461 aacggcacca gccgcatctt gtcgtagcgt cccccggtcg gcccgccggg gccgacgagc
     8521 acggagctct tgaagatgcc gggccggtcc gagcggcgcg cgtcgacgtt gacgaggagg
     8581 tccgccccca cctcgcggga gagcgcggtg agccggtccc ggagaccggg gtgctgcgcg
     8641 aggtcgccgc cgacgccgct ctcgccccac accacgaggt ccacccgctg cccggccagc
     8701 ttcctcgtga gctcctcctg gcggtcgaac cggtgctgga cgctgcccgt cccgtcgacg
     8761 acgcccggct ggacgagagc gatccggacg gtgcccgcgg agcgcggcga aggcacccac
     8821 atccacaccc cggcgacgac cgctgcacag cccgccaggc cgattagtcc ggtgatacgc
     8881 gcgcgagaag cccaaatgac cgtggaaaca gcggtgttga tggccacgag gaggaaacta
     8941 accagccaga tcccgcccgt tgaagcgagc ttgagagcgg gttgcacctg ccactgactc
     9001 gccccgaaca gaccccacgg tccgcccaaa tactcccatg aacgggcaag ttcgaccatc
     9061 aaccagccgg aaggtacggc gaggagggct gcggcggccc gcgccggccc cggggaaccg
     9121 cccagcagtc gcttgaccag cacgccccac ggcgcccaca gcagccccag cagcgcggcc
     9181 agcaccagga tgaagacgtg cagactcggc agcagccagt ggtgcacggc gagcaggaat
     9241 ccgccaccgc cgagccagcc gtcgagcgcc gcccgccgcg cggagggcgc cgtgcggatc
     9301 agggacagcc agggtacgag cgccacgtag gccagccacc acagcgaagg cgtgggaaac
     9361 gtgagtgcgg gaagcgctcc cgccaccacc gccgcagccg cccgcggcca gggccgggtc
     9421 ggcagcccgg cgtacgggcc gtccggcggt tgcgtcgtca tggtgtgcct ccctgggccc
     9481 gaacggtcac cggcgccgta gatcgtcgat cattcgtccg cgcgacgcat gagcgggatc
     9541 cggtcaacct ttatcttttc gaacagcaga ggatcatgag gaaaaaattc tgacatcggg
     9601 gtgcaatatt ccaccgccgc cactcatcgg aaaagctcct ttggtcgggt tcggtcagaa
     9661 atgatccgaa gtgagccttg catcctgcgc tggaaaggtg tgaccgggta tgcgccacgg
     9721 gttacctccg gtccaccctg ggcaggtacc gcgcaaaagc ggacaggaac gctgcgagcc
     9781 gtcctgggga ggcgccgtga cgggcgtgcg agatcgcata tcagtacagc ccttggaggt
     9841 cgtgcccttc tactgtccga taccgccggc ggtgcacccg ggcatccggg agatcgaccg
     9901 cacctcggtc gactggatgc tccagcgaca gctcgacacc tcggcgcacc agcggcaacg
     9961 cctcgcccgg tgcgacttcg gcgggctcac ggcccggacc atgccctacg gccagtccgg
    10021 accgctcacc gtcgtcgcca agctccacgc cgtgctcttc tccctggacg acgccctgtg
    10081 cgacgagtcg accgccaccg cccacggcct ggcgcacacg acctcacgca tcatgcgcgt
    10141 tctggaagcg ccggtaccgg agtggccgga tgactcgccc cacgccgcgg cgctgcgggc
    10201 cgtccgcctg gagctggccg agcacgcgac gccgagccag ctgcgccact ggaccgaggg
    10261 catgcgcacc tacctcaccg gcctggtgtg ggaggccgcc tgccgccgcg accgggccct
    10321 gccgtccgtg aacgactacg ccacgatgtg gatgcgcgcc atcggcatgg cgccctccac
    10381 ggccctgatg gacatcgccg gaggatacga actcgacgac cgcgacctgg accggcccga
    10441 ggtccgggcc ctcaccgaga tgacctggac gctcgtcgcc tgggacaacg acttctactc
    10501 acggaacaag gagatccggc gtgccggtga caacctcaac ctgatcgacg tcctcgccca
    10561 ggaacgggac tgggagcccg cccgggccca ggaagaggcc atggcgatgc gcgaccgcgt
    10621 catgacgctc ttcctgcgct tacgcgagca gatctggccc cgggccgggg tggaactgcg
    10681 ctgctacctg gtggcgctgg gccacttcgt ccgcgggcac ctggactggg cctcggcctg
    10741 cgcccgctac caggacccgt acgggaccgc cgccgacgtg gagtggtgga agccgctccc
    10801 gtcggacgac agcccggatg ccctgcccat ccccgccatc gcctggtggt gggaccagct
    10861 cgaggccggc tgctaccgcc gccccagcag acgccgcagc gacctccacc acgaccgccg
    10921 cgaaccgggc gtctccggac cggcggcccg gaccggcggc gccgggatgg ccggctgctc
    10981 ggcccgctcc ggctgagcgg gcaggggcgg ctccggcgcg ggtgtcagcg tctcctccgg
    11041 gggcagcggc gcccgcgccg tgaaccgcac cggcagcccg gtcaggtgac gggacatcag
    11101 ggtggagcgg taggtcagct ccgactcgtc caccgcgagg gtgaggtcgg gcaggcgcag
    11161 cagcagggcg tcgatgcccg tgtccgcgat cgcccggccc acgtcctggc ccgggcactc
    11221 gtgctggccc ccgctgaacg ccaggtgcga gcggttgccg tggacgggga cgtcgggatc
    11281 agggcggatg accgtgtcca tgttggcggc ggccagcccc aggatcaggg cgtccccctc
    11341 cttgatctgc tgacccgcca gctccgtgtc ctgcgtcgcc cagcggccca ggatcgagat
    11401 gaacggcggc tcgtcccaca ggacctgctc gaccgcatcc ggcagcgtca tgtgaccgcc
    11461 ggccagggac gcctggaagc ggtggtcggt gagcaccatc ttcagggtgt tcgcgatgag
    11521 gttcgccgtg gtctcgaagg ccgcgatcag caccagccgc agatgctgct ggacctcgtc
    11581 gtccgacagc ccggcggggt gctccagcag ccagctggtg aagtcggcgc ccggctcgac
    11641 gtgcttgcgc gccaccagct tgcgcagcgt ctcctggacg aactcgttgc tcgcgatcgc
    11701 cgtctcggtg cccttgatca tgtcccgggc ggcgttgacg agctgggggc tgtacgcctc
    11761 cggcatgccc agcagctgcg tcatcgccat catcggcagc tgctcggcga actcgtgcac
    11821 caggtcggcc cggcccgagg cgcagaagcg gtcgacgagc tggttcgagt actgggtgac
    11881 gtggcggcgg atgccccgct tgtcgaagcg ggcgatgctg tcgttgacgg cgccgcgcca
    11941 gcgctcgtgc tgctggccgt cggcgaagac gcagatcggc tgccaggtgg tgatcggcgc
    12001 gagcgggtgg gtcggggcca cgcggccctc gcgggcctcg atccaccgcc gggagtcgcg
    12061 cgagaagcgc gagggggtgc gcgccacgtc gaggttctcg cggtagccga ggacgagcca
    12121 ggccgggacg tcgtcgtgca gcaggacggg cgccacctgg ccgtgcttct ggcggagccg
    12181 ctcgtacagc cccatcgggt cggcctcggc ctccgggccg tacagccggg tgatcccgcc
    12241 ggggccggtc gcatgggccg ggcactgcgg gggaggcccg gccggggagg tggtgcgggg
    12301 gcgttcggaa gggagggtca ctggtgctcc gtggaggcgg tggtgagcgt gtagaggtag
    12361 cgcatgaggg tgagcagggt gtcgcggcac gaggcgcggt cgcgggcgtc gcagtcgatc
    12421 atgggcaccg agtcgtcgag gtccatggcc gagcggagct gctccatcgg gtatctgggc
    12481 gcctggggga agcggttgac gccgacgacg aagggcactc ccttctcctc gaggcgcccg
    12541 atcacgtcgt aactgacgtc catgcggcgg gtgtcgagga ggaccaccgc accgagggcg
    12601 ccctcgaaca ggccgttcca caggaaccag aagcgctcct ggccgggagt gccgaacaga
    12661 tacagcacca ggtgctcgtt gatgctgatc cggccgaagt ccatggccac ggtcgtctcg
    12721 gtcttgtgct cgatcccggc gatgtcgtcc acgccgacac cggcctgggt catcgtctcc
    12781 tcggtggtca gcggccggat ctcgctgacc gagcccacca gggtcgtctt gccgaccccg
    12841 aacccgccga cgatgacgac cttgacggcc gcggtggccg aggccggcag gacgtcctcg
    12901 ctgcgcggcc ccgcataggt ctccaacccg ggggagtcag agcttctgta gtccattcat
    12961 caccgcctcc agaagttgaa cgtcgggaag ggccgccgcc ggcaccggcg gccgggcctc
    13021 cacgtgacga cccgccacca gctccgtgag cagcagggtc agcgtgctga ccggcagttc
    13081 cagataggcc gatatctcgg cgacggagag cgggtaggca cacatccgga cgatggcggc
    13141 gtgctcgggc tgcagcccgg ggtcggcctc ggaccgggag acgatcagcg tcaccaggtc
    13201 gagctccgtc ttccgctccg cgcggggctc gcctccggtg aggatgtaga gccggtccgg
    13261 gctgccgggc gcggtcgggg agccgggtcc ctccgtgctc atgtcaccga cccgccgacc
    13321 cgcggcggac tggtgagatg cgaaccgatg cgggccacca gatcccgcat ccgcatgccc
    13381 atcagctcgg cgtccacgtc gtcgtcggcc agcaccgcga ggaaggctcc ggccccggcg
    13441 gccatcagat agaagaatcc gccgtcgacc tcgatcacga ccaggcgcat ctgcccgtcc
    13501 ccgtggggga attcaccggc gatcgcggtg gagaggctct gcagtccggc acaggcggcg
    13561 gcgaggcggt cggcggcgtc cgggtcggtg ccgtgctgag ccatgcgcag gccgtccgag
    13621 gacagcacga tcacgtggcg ggtctgcgga acactggttg ccaggtcctt gagcatccag
    13681 tccatgttga accgcggctg cgtcacttgg ctactcttcc ttgtctgacg ggatatcact
    13741 gtgcgaccgg ccggcatccg gctccaggga ctccccgttg atgccgcggt tgaaggcggc
    13801 cagccacatt ccgggctgct tgggggcctc ctccggagcg gccggcgcgg cgggcggggc
    13861 cggcggccgg tcccgccgtt cggccgcgcc ccggccgaac gggagcggcg cggggccgcg
    13921 gcgccgccgc cgctgcggca gtccgctgtc cccgagcggc ggcgggatgg ggtgctccat
    13981 catcggcgga gccgtctgcg gagcgggcgg ggggatcttc tggcccgggc ggcgcttgga
    14041 cttgaagggc gggagcttgg gcgcgcgggc gatgtcgccg ccggggtgct tgctggcggt
    14101 gatcaggtcc atggggatga ccagcacggc ccggacgcct ccgtaggcgg agggccgcag
    14161 cgacaccagg aagttgtacg tgcgggcgag ccggctgacg accgcgaggc ccagccgcgg
    14221 cgcctcgccg aggtcgtcga ggtcgagggc gccctcgcgg gagaggacgc ggtcggtgcg
    14281 gcggcgcgcc tcgtcggtga ggccgacgcc ggcgtcctcg atctcgacgg cgatgccgga
    14341 ctggatgtcc acggcggtca ggtgcacccg ggtctgcggg ggcgagtagc gggtggcgtt
    14401 gtccagcagc tcggccaggg cgtggatcac cggttcgacg ccggcgccga ccacggcgac
    14461 gtcggccacc gagtgcaggt cgacccgccg gtactccagg atccgcgaca tggcgccgcg
    14521 cagcacgttg tacagcggga tctcgttctt ccactggcgg ccggggcggg agccgccgag
    14581 gacggcgatg ctgtcggcga ggcggccggt cagggcgttg ccgtggtcga ggtggaggag
    14641 atcgccgaag acgtcggggt cgttgccgtg cttgtgctcc atctcccgga tgtcgtaggc
    14701 ctgctggtgc acgatggcct gcatgcgacg ggcgatgttg acgaaggcgc gctgcgcgga
    14761 gtcacgcagc ccctcctccg cctgcacggc ttcgatgacg gatttcagca ccgaccggtg
    14821 cgcggccgcg tagccgggct cgaggtcgtg gacgggaagc gtgtggcgca gcacgacctc
    14881 ggtgggggcg ccgcgctgca gcaggtggat ggcccggggg agcagctcct tggccagccg
    14941 ccgggtctcc gcctcgtgct ggtcgagctg gtaccgcagg ccggcctcct gctcggtgca
    15001 gcgccgccgc agggccgcga tgacccgtcc ccgccgggcg gcctcggagc ttgccagcgc
    15061 caccgcgacc gtggcggagg caccgcacca ggccaccggc acgcgggcgt cgggagcgac
    15121 ggcgaggacc gccgtacccg tgcacacggc cagtaccaag ggggagatca gccatatcag
    15181 agcggagacg ggccgccgtt gaactgacga gccagtacca accatcggga tcctcggaac
    15241 tcttaagaag gcgtagggcc cggcgcgcgg caatcccggg tgtctcccgc ggagaacggc
    15301 gccggcgcag cacttgtgcg caccgtgaag tagtcgccac aacccgctgc gcgacatgga
    15361 gcgtagccgg tcgcgcggtg ctcccgcgcg aagttgtcat attcgcagat tggcctgacg
    15421 caggaattcg aaaggctcga taatggcccc gcgcttcgaa ttccgaatgg gtttacgaat
    15481 cgtatgaatg tatgttcggt gcaagttggg catgctgccc gtggtgcgga acgggctcca
    15541 gtggcgggcg ggggagggtc acgctcccgg gtggtccgtc tgccgaaccc tgcccctggc
    15601 ctcacggacg gggctaggct cgctccacca catcttccgg ggagacatcg ccatgtcagg
    15661 gcatcagcgt gaacagaacg catccgccgc cctgttcgag cgggagctcg agctgcaagc
    15721 cgctgagcaa gcggtgcaaa ggctgtgcgg aactgcgacc gaagggcggt cccggctcgg
    15781 tggcctgctg ctctacagcg gcgaagcggg cctgggtaaa acggcgttgc tcaccaagac
    15841 gcgccggatg gccatcgagg cgggcaagtg caccgtcctc ttcgcgcgcg gcagcgagtc
    15901 cgcgcagccg gtccccttcc acgtcgtccg tcagctgctc cagccggtcc tggcgccgat
    15961 gagcgaggcc gaacggaagg agatgctcgg cggctggtac gagatcgcag gccccgcgct
    16021 gggcatcgcc ccgccggtcg gcccgcagga cccccagggc gtgcgcgacg gcatcgactg
    16081 gctcgtcacc caactcgcca cccgccagga gccggtggtg ctgatgatcg acgacgccca
    16141 ctgggccgac gccgagtcgc tcgcctggct ctcgttcttc gccgtgcgcc tgcaggagac
    16201 gccgctgctg gccgtcatcg cctaccgccc tgaggaactc gcggagaacg cgccgggctt
    16261 cagcgagctg gtcaccggcc gcagctcccg tcctgtggag ctgcgcgccc tgaccccgga
    16321 agcggtcaac cggctggtgc acggatcctt cccggaccag gccgacgccc cgttctgccg
    16381 cgaggtctgg gccgtcaccg gcggaaatcc ctacgagacc gtcgagttgg tcgccaaggc
    16441 gcaggaccgc ggcctcaagc cggtagagga gtccgcctcc ctcctgcgcg acctcggcgc
    16501 gacggcccgc ggcagcggtc tggtctcccg cctggagcgg ctgggcaccg ccgtcacccg
    16561 cttcgcctgg gcggcggccg tgctgggcac cgagatccag ccgtccctgg cggcgaacct
    16621 cgcgggcatg ggaccggccc aggccgccga gtgcgcggac aagctgcggc acgcccgtat
    16681 cctcaccggc gccatcgacc tggaattcgt ccacccgctg atcgccacgg ccatctacgc
    16741 ctcgatcccg ccggccacgc gcaccgccat gcacggacag gccgcctggt ccgtcaccga
    16801 ggcggggctg ggccccgccg cggcctcccg gcacctgctg gaggtccacc ccgaccacga
    16861 ctccgagctg gtcgagcagt tgcgcgtggc cgcccgcgag cacctggcgg tcggcgcccc
    16921 ggatgcggcc cgccgttgtc tggagcgcgc cctgcaggag ccgccgcccg aggaggagcg
    16981 ggcctcggtc ctctacgagc tgggctgctc cgcgctgctc acctcgccgt cgacgaccgt
    17041 caaccacctc aagacggcgc tgtccctgcc gcacctcacc gaggagctgc gcgtcgacgc
    17101 cacctaccgc ctctcccagg cctacgccca caacagccag ctgcgcgagg ccgccgaggt
    17161 cgtgaaggag caggccgagc gcaccccgcc gggcgccggg cggatgcgcc tgcaggccgc
    17221 gcactacctg tggcagggca tccaggtgga ggagcaggac tccctgggcc gttcgcgccg
    17281 catcgccgag ctcgccgaac gcatccgcgg ccgcgacaac accgagcgga ccctgctcgc
    17341 gctgcgcggc ttcgacggca tgatccgcgg cgaggacgcc gtgcaggtgg tcgagcacat
    17401 cgagcgcgcc ctcgtggacg gccggctcgc cgagggcatg gggtggacca acaccgagtg
    17461 gggcttcgag gtccccagca tcatcggcat caccttcgcc tacaccgacc ggctcgacca
    17521 tgccgaggag ctcttcaagg acgccgtgcg ggccttcgag atctccggct ggagcggcgg
    17581 tcacctcgcg ttcgcgcacg acttcctcgg tctggtgcac cgccgccgcg gcgagttgga
    17641 cgaggccgag gcgctgctgc gcgaggggct gcggctgggc aagcggctcg gccccggcct
    17701 gccgatccac tgggacggcg cctgcctgct gatcgacacg ctgctcgcgc gcggccgggt
    17761 cgacgaggcc caggccttcg ccgaggagaa cggtttccag gcgccctaca cgcccgccat
    17821 cgtgctgccc gacgccgcgt gcctggccgg acggctgctg ctcgcccagg gccgcaggaa
    17881 ggaggcggtc acggagctgg agaccgccgg gcgcaggctg gaggagcgcg ggcggaacaa
    17941 caccgtgtgg gccccgtggg cgctcgacct ggccgtcgcc gtgaaggacg aggagcccga
    18001 gcgcgcccgc gccctggccg acaaggccgt gcgcaacgcc gcgcgcttcg gcacggacac
    18061 cgccatcggt gacgccctgc gcagggccgc catcgtcgcc gagccggacg aggccctggt
    18121 gaagctcggc caggccgtgg tgcacctgcg ccgctccccg tgccgctacg agttcgcggc
    18181 ggccctggtc gcgcacggtt cggcgctgct gcgggccgac cggccggccg aggcgaccga
    18241 gcggctgcgc gaggggctgg aagtggccca gcagtgcgcg gccgacgggc tcgtggcgac
    18301 ggcccgggcc gatctcgcgt cggcggtgtg cgacggagtc gagccggcgg gtgatgccgt
    18361 gcgctgagcc cggccggctc cgggcccggc cgactccggt tcaggaagcg cggcggccgg
    18421 atttcccggt cgccgtcttc ttggccgtct tggccgtggc gctcttggcc gtgccgggct
    18481 tggccgtgga ggtggcggtc ttcttgccct tggcggtgga ggaggccgcc gcggtcttct
    18541 tggcggcggt gcgtttctgc ggtgcggcgg atttctttgc ggtgctgcgc gtcgatttcc
    18601 tgggcgcagc ctccctcttg gtgccctttt ccgtttcttc ccccgtcttt ccggccgctt
    18661 tgtcgatgga cgcctggagt gcggccatca ggtcgatgac gttgtccggt gcgggtgccg
    18721 tctccttctt ggggaccggc cggtcggaca ggtgggcgtt gatcagctcg ctcagggcga
    18781 tctcgtactc gtcctccagc tcgtcgaggt cgaactcctc ggagagggtg tccatcaggc
    18841 tcgtggccat cttcagctcc tgcggccgca cggtgaccga ggagggcggt gcgaggtcgc
    18901 cgctgtcgcg gatctcgtcc ggccagtaca tggtgtgcag ggtcagcagg tcgccgtgga
    18961 cccgcaggag ggccagggac tcccgggtcc gcagtgcgat cttggtgacg gccacccgct
    19021 cggtctgctt gagggtctcg cgcagcagga cgtagggctt gtcggccgcc gcgctctcgg
    19081 gggcgaggta gtagccgttg gagagctgca ggggatcgat ccggtcggcg tcgacgaagg
    19141 cgagcacgtc gatgagcttc ttgctgggca gcggcagccc ggccagctcg tcctgggtga
    19201 cgacggcggt gtgtccctcg tcgtcctgga agcccttggc gatgtgctcg tagtcgaccg
    19261 gctcgccgca ggcttcgcag atgcgcttga ggtggatccg gccgccgtcc gcgtcgtgga
    19321 cctggtgcag tctgaggccg tgttcctggg tggcggcgta cagccgtacg ggtacggaca
    19381 ccagtccgaa gccgatcgca cctttccaca tggtccgcat agttttatcc ctccacgggg
    19441 aattcctacc ttatgtctgt ctccccggag cggcaggcgg tggagatcga gggccaccgg
    19501 ctggccctga cccacctcga ccgggtgctc ttccccgcat cgggccacac caaggcgcag
    19561 gtgctgcagt actacgcacg catcgccccg gtgatggtgg cgcacacggc cgaccggccc
    19621 gcctccttcg tccgcgcccc ggagggaccg ggcgggcaga gctgggtcgc caagaacccg
    19681 cccggcggca agccccggtg ggtgcgggtg gtgccggtgg agcaccgcga gggcgtcacc
    19741 gagcaggtcg tcatcgacac cacggccgcc ctggtcgcga tggccaacct cggtgcgtac
    19801 gaggtgcacg tcccgcagtg gacggtgacg gccggccccg acggccacga ccggctcgtc
    19861 ctggacctgg accccggccc gggcgccgac ctcgtggtct gctgccgggt cgcccagcgg
    19921 ctgcgccagc tcctggacga cgacgggctg accgcccacg ccgtcgtctc cggctccaag
    19981 ggcctgcacc tgtacgcgcc ggtccacgcg gcgtccggcc gggccgccgg cggctacgcc
    20041 aaagcgctgg ccgcccgcat gatgggcgag caccccggcc tcgtcgtggt ctccatggcg
    20101 cgcgtcgaac gccgggggaa ggtcctcatc gactggtcgc agaacgcgag cgccaagacc
    20161 accgccgcgc cctacaccgt gcggctgcgg gagggcgtcc ccggagtggc cgccccggtc
    20221 acctgggacg aggtcgccgc gtgccgggac cccgaggagc tcgcgttcac ccccgagcag
    20281 gtgctggacc gggcggagac ctacggggac ctgctggccc cgctcaccgg cgacgccacc
    20341 cgcgcgcagc tcccgtgacg tcccgccgtc agccgagccg ggtcagatcg ggccgcagcc
    20401 ggtgccagac ggggtgccgg aggcggccgg acgccgtcca gccggagaag acgacctcgg
    20461 cgacgagccg gggctcgacc cagtgggcgc ccggcacgtc ggcggggccg gcgaagggcg
    20521 ggtccgcgcg cgggatcacc gccaggtagc gggccagttc ccggcgctcg cgctcggaga
    20581 gccccgatcc gacggacccg gcgtagcgc
//
