LOCUS       NZ_CP013141            10858 bp    DNA     circular CON 12-MAY-2024
DEFINITION  Lysobacter antibioticus strain ATCC 29479 chromosome, complete
            genome.
ACCESSION   NZ_CP013141
VERSION     NZ_CP013141.1
KEYWORDS    RefSeq.
SOURCE      Lysobacter antibioticus
  ORGANISM  Lysobacter antibioticus
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Lysobacter.
REFERENCE   1  (bases 1 to 5765176)
  AUTHORS   Kobayashi,D.Y. and Ravel,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-NOV-2015) Plant Biology & Pathology, Rutgers, The
            State University of New Jersey, 59 Dudley Road, New Brunswick, NJ
            08901, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: TiGR Assembler v. 2
            Genome Coverage                   :: 200x
            Sequencing Technology             :: Sanger; 454 FLX
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001442535.1-RS_2024_05_12
            Annotation Date                   :: 05/12/2024 11:28:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,784
            CDSs (total)                      :: 4,717
            Genes (coding)                    :: 4,635
            CDSs (with protein)               :: 4,635
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 12 of 82
            Pseudo Genes (incomplete)         :: 74 of 82
            Pseudo Genes (internal stop)      :: 2 of 82
            Pseudo Genes (multiple problems)  :: 6 of 82
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:11:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 368193
            Orig. end                         :: 379051
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP013141.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10858
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10858
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10858
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5858](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5858)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            242..427
                     /locus_tag="GLA29479_RS01535"
                     /old_locus_tag="GLA29479_350"
     CDS             242..427
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GLA29479_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GLA29479_350"
                     /product="hypothetical protein"
                     /protein_id="WP_057919732.1"
                     /transl_table=11
                     /translation="MPASFEIFAGLAVLAAAIVARDGKGTAKATKALAKLAKSDEDKPA
                     AKAVAKKAKQDPKTVA"
     gene            complement(483..977)
                     /locus_tag="GLA29479_RS01540"
                     /old_locus_tag="GLA29479_351"
     CDS             complement(483..977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646912.1"
                     /locus_tag="GLA29479_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_351"
                     /product="DUF2938 domain-containing protein"
                     /protein_id="WP_057919731.1"
                     /transl_table=11
                     /translation="MRTAAIGIGATALMDLWGLLRTRLLRMAAADYGLVGRWIAYLPRG
                     RFRHDPIAATPRVRGERAIGWTAHYLIGIAFAAVLLAMWGLDWARQPSLAPALIVGIGS
                     VAAPFLLMQPGMGAGLAARRTPRPGVARLQSLITHAVFGVGLYLAAVAANGLAGLQARM
                     A"
     gene            complement(994..1785)
                     /locus_tag="GLA29479_RS01545"
                     /old_locus_tag="GLA29479_352"
     CDS             complement(994..1785)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (8-119). E-value: 8.6e-16. Score:
                     48.9. Matches aSDomain:
                     nrpspksdomains_GLA29479_RS01545_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019184638.1"
                     /locus_tag="GLA29479_RS01545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_352"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_345775649.1"
                     /sec_met_domain="PCMT (E-value: 3.6e-06, bitscore: 25.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDGMFRPLQDRLVEAVSASAREVLDIGCGTGAVALALARRLGAA
                     GRCVGIDISEPMIALARTRADAEGGSAEFLCADAQTHAFAPARFDAIVSRFGVMFFADP
                     VAAFANLRRAAKQGAELHLIAWRGAADNPFMTTAERAAAPLLPTLPARKPDGPGQFAFA
                     DAQRVRRILDDSGWAEIDIQPIEATCSFPESELVRYLSRLGPLGLFLQEADERTRAEVV
                     KTVRAAFDPYVHGAEVRYRAACWMIGARAWSAPASNGADRA"
     aSDomain        complement(1429..1761)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GLA29479_RS01545_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="8.60E-16"
                     /label="GLA29479_RS01545_oMT.1"
                     /locus_tag="GLA29479_RS01545"
                     /protein_end="119"
                     /protein_start="8"
                     /score="48.9"
                     /tool="antismash"
                     /translation="LQDRLVEAVSASAREVLDIGCGTGAVALALARRLGAAGRCVGIDI
                     SEPMIALARTRADAEGGSAEFLCADAQTHAFAPARFDAIVSRFGVMFFADPVAAFANLR
                     RAAKQGA"
     misc_feature    complement(1838..1853)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.01"
                     /tool="antismash"
     gene            1942..2379
                     /locus_tag="GLA29479_RS01550"
                     /old_locus_tag="GLA29479_353"
     CDS             1942..2379
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019465884.1"
                     /locus_tag="GLA29479_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_353"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_057919729.1"
                     /transl_table=11
                     /translation="MKELDIAEVAQRSGVPASTLRYYEEKGLIAPIGRRGLRRVFADGV
                     LERLALIALGRAAGYSLDEIASMVAPDGPPRIDREQLRAKADELDRTIRQLSAMRDGLR
                     HAAACKAPSHMECPTFRRIVQAAASGAIGARTRKHPQRSRD"
     misc_feature    complement(2549..2569)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     gene            2569..3510
                     /locus_tag="GLA29479_RS01555"
                     /old_locus_tag="GLA29479_354"
     CDS             2569..3510
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013736.4"
                     /locus_tag="GLA29479_RS01555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_354"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_057919728.1"
                     /transl_table=11
                     /translation="MNVIAMKPETERQRALDQTRIVDSLPEPVYQDLVCLAAAICDTSI
                     ALISLVDRDRQWFKAKLGIDEREMPRSMAVCDHAIRKPAELFEVRDLASDPRFSEFPYV
                     RDGRARFYAGVPLLTEQGAAIGTVCVLDQAPRTLDEQQRNALRSLSRVTSALIEAHRGK
                     HVAEVKTLLQPQAKAPGPERAPQSLTIAVIRIQGYAELVARLGERATEKLLQALDQVLD
                     QGLRHDLGDHIDRITGTPEYVAILRGDEVATRLNALRAALDRHQSSTSAAWAMGVAHAR
                     EPVEPMPAIYLRADEELSRQLDQAAGRMTAAA"
     gene            complement(3558..4211)
                     /locus_tag="GLA29479_RS01560"
                     /old_locus_tag="GLA29479_355"
     CDS             complement(3558..4211)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005415657.1"
                     /locus_tag="GLA29479_RS01560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_355"
                     /product="hypothetical protein"
                     /protein_id="WP_057919727.1"
                     /transl_table=11
                     /translation="MTASSVLQRLTGWRLFLLLAVVLCAIAAAAFLIGPDAVEGSRRAI
                     RVTARTSFVLFLAAFTASSFAILLPGDFSRALLRERRIVGLSFAFSHLLHAFAIYAFGQ
                     LDPAFWPSRSALTNVPGSLGYAFIALLAITSYRPLARRLGPTAWHRLHVAGMWIIATIF
                     AYSYFKRVPVNFWYAVPSALLFTAVVIRLIAKRAQAIKRGARTAPSAGPLRTQP"
     gene            complement(4208..5008)
                     /locus_tag="GLA29479_RS01565"
                     /old_locus_tag="GLA29479_356"
     CDS             complement(4208..5008)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="GLA29479_RS01565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_356"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_057919726.1"
                     /transl_table=11
                     /translation="MTESLRTLQLAWARHLRDPSHPPLHDVAPQRMALYRSLCVGAVEN
                     LLASSFPRLRRALQAPGWQALVTRFYARHRCETPLFPEVGGELVDYLSQADTSDLPGWV
                     AELAHFEWTRQALLLAATTAPATGCVPMTADSVPMLSPLVRVCGYRWPVDAAEAGLSGL
                     EDPPDAPTLLIVQRGADHELRTLRVTAFSYRLLLAVSAQPLSSRDHLRALAEEAGEPAD
                     RLLEHGLDVLARLQALGIVDSQVHTTGSAGNSRPHSNPSTGASA"
     misc_feature    complement(4304..4306)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5001..5858)
                     /locus_tag="GLA29479_RS01570"
                     /old_locus_tag="GLA29479_357"
     CDS             complement(5001..5858)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010483448.1"
                     /locus_tag="GLA29479_RS01570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_357"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_057919725.1"
                     /sec_met_domain="DUF692 (E-value: 3.6e-114, bitscore:
                     378.6, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQTLPAASAGLGLRRGLIDELLGLAPGQVDFLECAPDNWIGVGG
                     HFGEALAELSARFPITCHGLSLSLGGTDPLDGKLLADTRRFLDRHRVGLYSEHLSYCAV
                     GGHLYDLLPLPFTDEAVRHVSARIAQVQDTLGRRIAVENISYYATPQPAMSEIDFINAV
                     LAQADCDLLLDINNVFVNACNHGYDALDFIARIPPERVASYHVAGHLDQDDGFKVDTHG
                     APVKALVWALLEQAHLRFGARPTLLERDFNFPAWDELLGELAQIRALQAEAVRSMHPSE
                     LGHD"
     gene            complement(5914..6366)
                     /locus_tag="GLA29479_RS01575"
                     /old_locus_tag="GLA29479_358"
     CDS             complement(5914..6366)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010483445.1"
                     /locus_tag="GLA29479_RS01575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_358"
                     /product="hypothetical protein"
                     /protein_id="WP_057970569.1"
                     /transl_table=11
                     /translation="MSTSHSRNSLVGALSIVLAGGALFGAQAMAAQPQALTGFAGIAAA
                     EGKCGEGKCGAAKTGTSAKKAVAEGACGEGKCGDASFAKTDGNHDGKVSRAEFLAVAAG
                     RAADFDRIDRGRDGYISEAEAHDFLKRTYQANGKPMPKGLFSQIAD"
     gene            complement(6453..7115)
                     /locus_tag="GLA29479_RS01580"
                     /old_locus_tag="GLA29479_359"
     CDS             complement(6453..7115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012479418.1"
                     /locus_tag="GLA29479_RS01580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_359"
                     /product="DoxX family protein"
                     /protein_id="WP_057919723.1"
                     /transl_table=11
                     /translation="MLPSFITRLGPRLDRVGASLSPLGLRVLLAWEFYEAGIEKLHGQN
                     WFADIAQRFPFPFSRLSPDLNWTMATWLELGCSLALLLGLGTRAVAYVLWVLTVVAIAA
                     VHWPEHWNGLAELWRGYAISDEGFGNFKLPLIYLVMLLPLMLGGGGSLSLDRLFRRAAP
                     DLARGDLLGWGVVAVALCLPLSALLPLPATIGALIGLASIALHLTKSRRPAPALSAA"
     gene            7461..8255
                     /locus_tag="GLA29479_RS01585"
                     /old_locus_tag="GLA29479_360"
     CDS             7461..8255
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010483441.1"
                     /locus_tag="GLA29479_RS01585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_360"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_057919722.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.2e-17, bitscore:
                     61.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTLLFASLLAATAGSSVAAEHVRPLDPHALTVVLVHGAFADGS
                     SWGQVIPRLASWGVPAVAVQNPLTSLEDDVAATRRAIRAAPGKVVLVGHSWGGTVITEA
                     GNDPKVSALVYVAAFAPDAGENSAQQGQGYPVAPGLSRLLEREGFLSLPEAAVREDFAP
                     DLKPATARLIYRTQGPLKASALAEPVTQAAWRGKPSWYVLSRHDRMLSPQLQAATARRI
                     GAQVHSLSASHVSLLSQPGAVTDAILEAAGIQAAATAADSGG"
     gene            8257..8949
                     /locus_tag="GLA29479_RS01590"
                     /old_locus_tag="GLA29479_361"
     CDS             8257..8949
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014713.4"
                     /locus_tag="GLA29479_RS01590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_361"
                     /product="cytochrome c biogenesis CcdA family protein"
                     /protein_id="WP_057919721.1"
                     /transl_table=11
                     /translation="MIALALAALAGMATLLSPCVLPMLPIVLARGAGGDRREPLLISVG
                     FIGAFAGGGIALGLLASSSGRFEAAVRLAAITVLLLAGLSCVWPQVFERVQARWLAGSR
                     LLAWRPRAAGPGGALLVGVSLGIAWTPCAGPILASVLALAAGAQDPARASALLGMYALG
                     AAAPLMAVIYGGRWAAARMASLQRHTGWLRRAFGVVAVAMALLQLAQLDTALIAWLLPW
                     LPSISTGL"
     misc_feature    complement(8258..8273)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    complement(8957..8968)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.9"
                     /tool="antismash"
     gene            9063..9551
                     /locus_tag="GLA29479_RS01595"
                     /old_locus_tag="GLA29479_362"
     CDS             9063..9551
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005415663.1"
                     /locus_tag="GLA29479_RS01595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_362"
                     /product="thioredoxin family protein"
                     /protein_id="WP_237051844.1"
                     /transl_table=11
                     /translation="MTSTVAPDLAGGGSWINSEPLSLPKLRGKVVLVEFWTYSCINCLR
                     VLPHVSQWHQRYAAQGLVVIGVHTPEYGYERVGANVRAAVKRLGIGYPVVQDNGFRIWN
                     AYGNRYWPALYLIDRQGRIVYRHFGEGDYAVTEAAIREQLARPSAASAPRVTIASAVR"
     gene            9570..10310
                     /locus_tag="GLA29479_RS01600"
                     /old_locus_tag="GLA29479_363"
     CDS             9570..10310
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019659345.1"
                     /locus_tag="GLA29479_RS01600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GLA29479_363"
                     /product="response regulator transcription factor"
                     /protein_id="WP_082638196.1"
                     /transl_table=11
                     /translation="MTHVDHILIVDDDREIRRMVADYLQKNGLRTTTAADGREMRAALE
                     TSDVDLIVLDVMMPGEDGLSLCRGLRAGPHRAVPVVMLTARDDETDRIVGLEMGADDYV
                     VKPFSSRELLARISAVIRRTRMLPPNLQVSEAGRLIGFGQWRLDTTARHLLDAAGTAYP
                     LSGAEFRLLRVFLDHSQRVLSRDQLLNLTQGRDANLFDRSIDLLVSRLRQRLLDDPREQ
                     AYIKTVRSEGYVFCQAVTLLDETP"
ORIGIN
        1 tcaccaacaa cggcccggac gccgtcaccg gtgcgatcct gcgcgaccag gcggccggcc
       61 gcagcgggtt gacctgcaac ggaacgccga cctgcaccgg cagcgcctgc cccggcgggc
      121 tgacgatggc agcgcttgag gccggtgtcc ccctcggcac gctggcgagc ggagcgagcg
      181 tgaccgtgac cctgccgtgc acggtcgact gagcgccgta cacggcaaac gtagccggcg
      241 cttgccggct tcattcgaaa tcttcgccgg cctggcggtg ctggccgcgg cgatcgtcgc
      301 gcgcgacggc aagggcacgg ccaaggcgac caaggccctg gccaagctgg cgaaaagcga
      361 cgaagacaag ccggccgcga aggccgtcgc caagaaggcg aagcaggacc cgaagacagt
      421 ggcctgacac gcaggcgcca ctcatccgtg gctcggcgat cacctcgagc caccgggccg
      481 gctcaggcca tgcgcgcctg gagcccagcc agcccgtttg ccgcgaccgc cgccaggtac
      541 agcccgaccc cgaacacggc gtgggtgatc aggctctgca gacgcgcgac gccggggcgc
      601 ggcgtgcggc gcgcggcgag gccggcgccc atgcccggct gcatcagcag aaacggtgcg
      661 gcgacgctgc cgatgccgac gatcaaggcc ggggcgaggc tcggctggcg cgcccagtcg
      721 agtccccaca tggcgagcag caccgccgcg aaggcgatgc cgatcagata atgggcggtc
      781 cagccgatcg cgcgttcgcc gcgcacgcgc ggcgtcgcgg cgatcgggtc gtggcggaag
      841 cgtccgcgcg gcaagtaagc gatccaacgg ccgaccaggc cgtaatcggc cgcggccatg
      901 cgcaacagcc gggtccggag gagaccccag aggtccatca gcgccgtcgc accaattccg
      961 atggcggcgg tacgcatgag cgcttcgaca agctcaggca cggtctgcgc cgttcgacgc
     1021 cggcgcagac caggcgcgcg cgccgatcat ccaacaggcg gccctgtagc ggacttcagc
     1081 gccgtgtaca tagggatcga acgcggcgcg taccgtttta acgacttcag cgcgggtgcg
     1141 ctcgtcggct tcctgcagga acaggccgag cggccctagc cggctcaggt agcggaccag
     1201 ttcgctctcc gggaaactgc aggtcgcctc gataggttgg atatcgatct ccgcccagcc
     1261 gctgtcgtcg aggatgcgac ggacgcgctg cgcatcggcg aaagcgaatt ggccggggcc
     1321 atcgggcttg cgcgcgggca gcgtcggcag cagcggggcg gcggcgcgtt cggccgtggt
     1381 catgaacggg ttgtcggcgg cgccgcgcca ggcgatgagg tgcaactcgg cgccctgttt
     1441 cgcggcccgc cgaagattgg cgaaggcggc gaccgggtcg gcgaagaaca tcacgccgaa
     1501 gcgcgaaacg attgcatcga agcgcgccgg tgcgaaggca tgggtttgcg catcggcgca
     1561 caggaactcg gcggacccgc cttcggcatc ggcccgcgtc cgcgccagcg cgatcatcgg
     1621 ttcggaaata tcgatgccga cgcagcggcc cgcggcgccg agccgacgtg ccagtgcgag
     1681 cgcgaccgcg ccggtgccgc agccgatgtc cagcacctcg cgcgccgatg cggaaaccgc
     1741 ttcgacgagc cggtcctgca agggtcggaa catgccgtcg agcaacgcct gggcgtcgac
     1801 ccaggcctgt ccggccaggc cgttccagag ctgcgcctgt tcgttgccgg cgtcgtatgc
     1861 ggtgttcatg tccgtgtcct gattgccatc cagcggcgga agcggcactg tgccaattca
     1921 agtcgacttg aggtcaagag ggtgaaggaa ctggacatcg ccgaggtggc gcagcgctcc
     1981 ggagtgcctg cctcgaccct gcgctattac gaagaaaaag gcctgatcgc cccgatcggc
     2041 cggcgcggcc tgcgccgcgt gttcgcagac ggcgtgctgg aacggctggc gctgatcgcg
     2101 ctcggacgcg ccgccggcta cagcctcgac gagatcgcat cgatggtcgc gcccgatggc
     2161 cccccgcgca tcgatcgcga gcaactgcgc gccaaggccg acgagctcga ccggaccatt
     2221 cgccagctca gcgccatgcg cgacggcctg cgccacgccg cggcgtgcaa ggcgccgagc
     2281 cacatggaat gcccgacctt ccgccgcatt gtccaggccg ccgcatccgg cgccatcggt
     2341 gcccgcacgc gcaagcatcc gcagcgatcg cgcgactgag cgaacgcgca atcggaacgc
     2401 gcagtccgag caaggcatct catcgtaatc ggatgccgcc gttccgccgt tggagaaggg
     2461 gggctgctcc atcccgcggg caactttcgg cattcatgca ggtcgtgaat tcaccaccgc
     2521 ctaacgtggc cggcgttgta gttccgatca cgtcaccgga gctatgccgt gaacgtcatc
     2581 gccatgaaac ccgaaaccga acgccaacgc gcgctcgatc agacgcgcat cgtcgacagc
     2641 ctgccggagc cggtgtatca agacctggtg tgtctggccg cggcgatctg cgacacctcg
     2701 atcgcgctga tctcgctggt cgaccgcgac cgccaatggt tcaaggccaa gctcggtatc
     2761 gatgagcggg agatgcctcg cagcatggcg gtgtgcgatc acgcgatccg caaacccgcc
     2821 gagctgttcg aggtgcggga tctggcgagc gacccgcgct tcagcgaatt tccttatgtg
     2881 cgcgacggcc gcgcgcgctt ctacgccggc gtgccgctgc tgaccgagca aggcgcggcg
     2941 atcggcacgg tctgcgtact cgatcaggcc ccgcgtacgc tggacgagca gcagaggaat
     3001 gcgctgcggt cgctgtcgcg ggtgacctcg gccctgatcg aggcgcaccg cggcaagcac
     3061 gtcgccgagg taaagaccct gttgcaacca caggcgaagg cgcccggccc ggagcgcgcg
     3121 ccacagtctt tgacgatcgc ggtgatccgc atccaaggct atgccgaact cgtcgcaaga
     3181 ctgggcgagc gcgcgaccga gaagctgctg caagccctcg accaggttct cgaccagggc
     3241 ttgcgccacg atctgggcga tcacatcgac cgcatcaccg gtacgcccga gtacgtcgcg
     3301 attctgcgcg gcgacgaggt cgcgactcga ctcaatgcgt tgcgcgccgc gctggatcga
     3361 caccagtcct cgacctcggc cgcgtgggca atgggcgtgg cgcatgcgcg cgagccggtc
     3421 gagccgatgc cggccatcta ccttcgcgcc gacgaggagc tcagccggca attggatcaa
     3481 gccgcgggcc gcatgactgc cgctgcgtag gtcctcaccg ctgcgcagtc acgatcctgg
     3541 cggccagctt gccgcgctca tggctgcgtt ctcagcggcc ctgccgacgg cgcggtgcgc
     3601 gcgccacgct tgatggcctg cgcacgtttg gcgatcaggc ggatcaccac cgcggtgaac
     3661 agcagcgccg acggcaccgc gtaccagaaa ttgaccggca cccgtttgaa gtacgagtag
     3721 gcgaagatcg tggcgatgat ccacatgccg gcgacgtgca ggcgatgcca ggcggtcggt
     3781 cccaggcgcc gtgccagggg ccggtacgag gtgatcgcga gcagcgcgat gaaggcgtag
     3841 ccgaggctgc cggggacgtt ggtcagcgcc gaacggctcg gccagaacgc cgggtcgagc
     3901 tggccgaatg cgtagatcgc gaacgcatgc agcaaatgcg agaacgcgaa cgacagcccg
     3961 acgatgcgcc gctctctcaa cagtgcgcgg ctgaagtcgc cgggcaacag gatcgcgaac
     4021 gaggaggcgg tgaaggccgc caggaacagc acgaacgagg tgcgcgcggt cacacggatg
     4081 gcgcggcggc tgccttcgac cgcgtcgggg ccgatcagga aagcggctgc cgcgatggcg
     4141 cacaggacga cggccagcag caggaacagc cgccaaccgg tgaggcgttg caggacggag
     4201 gaggcggtca tgcggatgct ccagtgctcg ggttcgaatg ggggcgggag tttccggcgg
     4261 agccggtcgt gtggacctgg gagtcgacga tgccgagggc ttgtaaccgc gcgagcacat
     4321 cgaggccgtg ctcgaggagg cgatcggccg gttcgcccgc ttcctccgcc aaggcccgta
     4381 ggtgatcgcg gctgctcagc ggctgcgccg acactgcgag caacaagcga tagctgaaag
     4441 ccgttacgcg cagggtccgc agctcgtgat cggcgccgcg ttggacgatc agcaaggtcg
     4501 gcgcatcggg tgggtcttcg aggccgctca gcccggcttc ggcggcatcc accggccagc
     4561 gatagccgca tacgcgcacc agcggcgaca gcatcggcac gctgtcggcg gtcatcggta
     4621 cgcagcctgt cgccggcgcg gtggttgcgg ccagcaacag cgcttgccgg gtccactcga
     4681 aatgcgcgag ttccgcgacc cagccgggca ggtcggaggt atcggcctgg ctcaggtagt
     4741 cgacgagctc gccgccgact tcggggaaca gcggcgtctc gcagcgatgc cgcgcataga
     4801 agcgggttac caacgcctgc cagcccggtg cctgcaacgc ccggcgcaac cgcgggaagc
     4861 tgctggccaa tagattctcg accgcgccca cgcacaggga ccggtacagc gccatgcgct
     4921 gcggcgctac gtcgtgcagc ggcggatgcg acgggtcgcg caggtgccgc gcccacgcca
     4981 gttgcagggt tctcaacgat tcagtcatgg ccgagctccg atggatgcat cgagcggacg
     5041 gcctcggcct gcagcgcgcg gatctgcgcg agctcgccga gcagttcgtc ccaggccggg
     5101 aagttgaagt cgcgttcgag cagggtcggt cttgccccga agcgcagatg cgcctgttcg
     5161 agcagggccc agaccagggc tttcaccggt gcgccatggg tgtcgacctt gaaaccgtcg
     5221 tcctggtcca ggtgcccggc gacgtggtac gaggccacgc gctcgggcgg aatgcgcgcg
     5281 atgaaatcca gcgcgtcgta gccgtgattg caggcattga cgaagacgtt gttgatgtcg
     5341 agcagcagat cgcagtcggc ctgcgccaac accgcgttga tgaagtcgat ttcgctcatc
     5401 gccggctgcg gcgtcgcgta gtaggagatg ttctccaccg cgatgcgccg gcccagcgtg
     5461 tcctggacct gggcgatgcg cgccgacaca tgccgcaccg cctcgtcggt gaacggcaac
     5521 ggcagcagat cgtagaggtg accgccgacc gcgcaatagc tcaggtgttc gctgtacagg
     5581 ccgacccggt ggcgatcgag aaagcggcgc gtatcggcga gcagcttgcc atcgagcggg
     5641 tcggtgccgc cgagcgacag cgacagaccg tggcaggtga tcggaaaccg tgccgacagt
     5701 tcggccaggg cctcgccgaa atggccgccg acgccgatcc agttgtcggg cgcgcattcg
     5761 aggaaatcga cctggcccgg cgccagccca agcaactcgt cgatcagacc gcggcgcagg
     5821 ccgaggccgg ccgaggccgc aggcaatgtc tggttcatgg cggtgctccg cgtggatgag
     5881 cgccgccacc gcagggcgat ggcggcgcgg gtttcagtcg gcgatctgcg agaacagtcc
     5941 cttcggcatg ggtttgccgt tggcctggta ggtgcgcttg aggaagtcgt gcgcttcggc
     6001 ctcgctgatg tagccgtcgc ggccgcggtc gatgcggtcg aagtcggccg cgcggccggc
     6061 ggcgacggcg aggaactcgg cgcgcgacac cttgccgtcg tggttgccgt cggtcttggc
     6121 gaacgaggcg tcgccgcact tgccttcgcc gcaagcgcct tcggccacgg ccttcttcgc
     6181 cgacgtgccg gtcttggcgg caccgcattt gccttcgccg cacttgcctt cggccgcggc
     6241 gatacctgcg aagccggtca gggcctgcgg ttgcgcggcc atcgcttgag cgccgaacag
     6301 tgcgccgccg gccaggacga tgctcagtgc gccgacgagg gagttgcggg agtgggaggt
     6361 ggacatgggt ggtactccgg tgggatgcac gccaggcgtg cgggatgaat gccgcggtgg
     6421 cggcagggaa gcaggggaag gggcgaaacc gatcaggccg cggacaaggc cggcgccggc
     6481 cggcgcgatt tcgtcaggtg caaggcgatc gaggccagcc cgatcaacgc gccgatcgtc
     6541 gccggcaagg gcagcagtgc gctcagcggc aggcacaggg cgaccgcgac cacgccccag
     6601 ccgagcaagt cgccgcgcgc gaggtcgggt gccgcgcgcc ggaacagccg gtccaggctc
     6661 agcgagccgc cgccaccgag catcagcggc aacagcatta ccagatagat cagcggcagc
     6721 ttgaagttgc cgaagccctc gtcgctgatc gcatagccgc gccacagctc ggccaggccg
     6781 ttccagtgct cgggccagtg caccgcggcg atcgccacca ccgtcagcac ccacaagacg
     6841 tacgcgacgg cgcgcgtgcc caggccgagc agcagggcga ggctgcagcc cagttcgagc
     6901 caggtcgcca tggtccagtt gagatcgggg ctgaggcgcg agaatggaaa cggaaagcgc
     6961 tgggcgatgt cggcgaacca gttctggccg tgcagttttt cgatgccggc ttcgtagaac
     7021 tcccaggcca gcaggacgcg cagaccgagc ggcgacagcg atgctccgac gcgatcgagg
     7081 cgcgggccga ggcgggtgat gaaggacggc aacatgcgag gctcctggct ggacgagtgg
     7141 cgaaagaccg ggagccatta cgcgatcgcg acgtatccgc agggtgtcgg gcgaagcgcg
     7201 gatttgtgta ccaatgtggc cgcgcgcggc cgcggataca ttgcgatacg aatcggccgg
     7261 gccgcgacgc tgccggccgt ggcaggaccc ggcatgcccc cggcgccggg cgttccgtgc
     7321 cggcgcggcg gcaggggttt gtaagcgaac gtatccggcg ccgccggcga ggtcttgcga
     7381 tacaagaagc gatgcgcgcg gaaacacagg cgatacagcc gcgacgtgca atggccactc
     7441 ccaagtccag gagtgtcccc atgatccgca cactgttgtt cgcctcgctg ttggccgcga
     7501 ccgccggctc gtctgtggcc gccgagcacg tccgcccgct cgatccgcac gcactgacgg
     7561 tcgtactggt ccacggcgcc ttcgccgacg gctccagctg gggccaggtc attccacgtc
     7621 tggcgtcctg gggcgtgccc gcggtggcgg tgcagaaccc gctgacctca ttggaagacg
     7681 acgtcgccgc gacccgccgt gccatccggg ccgcgcccgg caaggtggtg ttggtcggcc
     7741 actcctgggg cggcacggtc atcaccgagg ccggtaacga ccccaaggtg tcggccttgg
     7801 tctatgtcgc cgcgttcgcg cccgatgccg gcgagaactc cgcccaacaa gggcagggct
     7861 atccggtcgc gccgggcttg agccgtctgc tcgaacgcga gggttttttg tccttgccgg
     7921 aagcggcggt gcgcgaggat ttcgccccgg acctcaagcc ggcgacggcg cgcctgatct
     7981 accgcactca gggaccgctg aaggcgagcg ccctggccga gccggtgacc caagccgcat
     8041 ggcgcggcaa gccgagctgg tacgtgctgt cgcgacacga ccgcatgctg tcgccgcagt
     8101 tgcaggccgc gaccgcccgc cgcatcggcg cgcaagtgca ttcgctgtcg gccagccatg
     8161 tgtcgctgtt gtcgcaaccg ggcgcggtga ccgacgcgat tctcgaagcc gccggaatcc
     8221 aggccgctgc caccgccgcc gatagcggag gctgaggtga tcgctctcgc cctggccgcg
     8281 ctcgccggca tggccaccct cctctcgccc tgcgtgctgc cgatgctgcc gatcgtgctg
     8341 gcgcgcggcg ccggcggcga tcgccgcgag ccgctgctga tcagcgtcgg ctttatcggt
     8401 gcgttcgccg gcggcggcat cgcgctcggt ctgctggcgt cgtcgtcggg gcgcttcgaa
     8461 gccgccgtgc gcctggccgc gataacggtg ttgctgctcg cggggttgtc ctgcgtgtgg
     8521 ccccaggtgt tcgagcgggt gcaagcgcgt tggctggccg ggtcgcggct gctggcttgg
     8581 cggccgcgcg ccgccgggcc gggcggtgcg ctgctggtcg gggtctcgct cggcatcgcc
     8641 tggacgccct gtgccggccc gatcctggct tcggtgttgg cgctcgccgc cggtgcgcag
     8701 gacccggcgc gggccagcgc gctgctgggc atgtacgcgc tcggcgcggc ggcgccgttg
     8761 atggcggtga tttacggcgg tcgttgggcc gccgcgcgca tggcctcgct gcaacggcat
     8821 accggctggc tgcgccgcgc attcggcgtg gtggcggtgg ccatggccct gctgcaactc
     8881 gcgcaactgg ataccgcgct catcgcctgg ctgctgccat ggcttccttc gatctccacc
     8941 ggactatgac catgccgaaa tcctttgctg cattgttcac cgccgccgcc gtcactgttg
     9001 cggctgtcgc catcgcgacc gccctggcct ggccggaggc ggccgcccag ggcaagggct
     9061 ccgtgacctc caccgtcgcg cccgaccttg ccggcggcgg ttcctggatc aacagcgaac
     9121 cgttgtcgtt gcctaagctg cgcggcaagg tggtgctggt cgagttctgg acctactcgt
     9181 gcatcaactg cctccgcgtg ctgccgcatg tctcgcaatg gcaccagcga tacgccgcgc
     9241 agggcctggt ggtgatcggc gtgcacacgc ccgaatacgg ctacgagcgg gtcggcgcca
     9301 atgtccgcgc ggcggtgaag cgtctgggca tcggttatcc ggtcgtgcag gacaacggct
     9361 tccgtatctg gaacgcctat ggcaaccggt actggccggc gctgtatctg atcgaccgcc
     9421 agggcaggat cgtctatcgc catttcggcg aaggcgacta cgctgttacc gaagccgcga
     9481 tccgcgagca gctggcgcgc ccgtccgccg cgtcggcgcc gcgcgttacc atcgcaagcg
     9541 cagtgcgata agccctccga gaccacgcca tgactcatgt agaccacatc ctgatcgtcg
     9601 acgacgaccg cgagatccgc cggatggtcg ccgactatct gcagaagaac ggcctgcgca
     9661 cgaccaccgc cgcggacggc cgcgaaatgc gtgcggcatt ggagaccagc gacgtcgacc
     9721 tgatcgtgct cgacgtgatg atgcccggcg aagacggcct gtcgctgtgt cgcggcctgc
     9781 gtgccggccc gcaccgcgcc gtgccggtgg tgatgctgac cgcgcgcgac gacgagaccg
     9841 accgcatcgt cggcctggag atgggcgccg acgactatgt ggtcaagccg ttttcctcgc
     9901 gcgaactgct ggcccgcatc agcgcggtca tccgccgcac ccgcatgctg ccgccgaacc
     9961 tgcaggtcag cgaggcgggg cgcctgatcg gtttcggcca gtggcgcctg gacaccaccg
    10021 cgcgccatct gctcgatgcc gcgggcacgg cctatccgct cagcggcgcc gagttccgcc
    10081 tgctgcgcgt gttcctcgat cattcccagc gcgtgctcag ccgcgatcag ctgctgaacc
    10141 tgacccaggg ccgcgacgcc aatctgttcg atcgctccat cgacctgctg gtcagccgcc
    10201 tgcgccagcg cctgctggac gatccgcgcg aacaggccta catcaagacc gtgcgcagcg
    10261 aaggctacgt gttctgccag gccgtcactc tgctggacga gacgccatga acgcggcgtc
    10321 gcgctggcgc ttgttcccgc gcaccatcgc cgcgcgcctc accctgatcc tgttcgccgg
    10381 gctgctgctg gcgcacgcgc tgtcgttcgc gctgctgttc tacgagcgct acgtctcggc
    10441 gcgctcgatg atgctgggga acatggagca ggacgtcgcc atcagcgtgg ccttgctcga
    10501 ccggatgtcg ccggcggaac gcaaccagtg ggcgccgcgt ctggagcgcc gcacctatcg
    10561 ctacctgctg caacccgcgc aaatcggcaa gccgatcgcc agcgaacgcg cgcgccaggt
    10621 cgcggcgttg atcgaccgca gcctgcagca ccgctatcgg ctcgtgacca cggcggtctc
    10681 gcaatcgccg gagcgcttcc aggtgcagct gaagttggcc gacgggcagc cgctgaccct
    10741 ggaagtgacg ccgtcggtga tgccgatcgc gcgctggctg ccgtgggtgc tggcggcgca
    10801 actcgccctg ctgttgctat gcgcctggct ggccgtgcgc ttggcgaccc gcccgctg
//
