LOCUS       NZ_LMFT01000012        19444 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root55 contig_2, whole genome shotgun sequence.
ACCESSION   NZ_LMFT01000012
VERSION     NZ_LMFT01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root55
  ORGANISM  Streptomyces sp. Root55
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 748558)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 748558)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140605
            Assembly Name                     :: Root55
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001427245.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 01:50:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,084
            CDSs (total)                      :: 7,008
            Genes (coding)                    :: 6,730
            CDSs (with protein)               :: 6,730
            Genes (RNA)                       :: 76
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 278
            CDSs (without protein)            :: 278
            Pseudo Genes (ambiguous residues) :: 0 of 278
            Pseudo Genes (frameshifted)       :: 105 of 278
            Pseudo Genes (incomplete)         :: 225 of 278
            Pseudo Genes (internal stop)      :: 24 of 278
            Pseudo Genes (multiple problems)  :: 67 of 278
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 729114
            Orig. end                         :: 748558
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMFT01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19444
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..19444
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19444
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:16538](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16538
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(136..1077)
                     /locus_tag="ASD51_RS16160"
                     /old_locus_tag="ASD51_07045"
     CDS             complement(136..1077)
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049646.1"
                     /locus_tag="ASD51_RS16160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07045"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_056792462.1"
                     /transl_table=11
                     /translation="MGAGHDHGHTHGGPPPTGTAAAAYKGRLRVALGITLGVMVMEIIG
                     GLLSDSLALIADAAHMATDALGLGMALLAIHFANRPAGPNRTFGFARAEILAALANCLL
                     LLGVGGYLVFEAVDRFITPAETQGGLAIAFAAVGLVANVVSLSLLMRGQKDSLNVRGAY
                     LEVVADTLGSVTVLVSAGIIMATGWQAADPIASLLIGLMIVPRTVKLLRETLNVLLESA
                     PKGVDMEEVRAHITALPGVLDVHDLHAWTITSGMPVLSAHVVVHQEMLDSIGHEKLLHD
                     LQGCLGVHFDVEHCTFQLEPSGHAEHEARLCH"
     misc_feature    1170..1184
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     gene            complement(1241..2224)
                     /gene="galE"
                     /locus_tag="ASD51_RS16165"
                     /old_locus_tag="ASD51_07050"
     CDS             complement(1241..2224)
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (64-206). E-value:
                     2.5e-10. Score: 31.8. Matches aSDomain:
                     nrpspksdomains_ASD51_RS16165_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049647.1"
                     /locus_tag="ASD51_RS16165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07050"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_056792463.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.7e-18, bitscore:
                     60.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.8e-13,
                     bitscore: 44.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWLITGGAGYIGAHVARAMTGAGEKVVVLDDISTGIAGRLPADI
                     ELVRGSAHDRGLLDRVLAEHAITGVVHLAAKKQVGESVEKPLLYYRENVTGLAVLLEAV
                     VAAGVRQFLLSSSAAVYGVPDTDLIAEDTPCAPINPYGETKLVGEWMVRAAGRAHGIST
                     ACLRYFNVAGTDRPELSDTGVFNVVPMFFDRLTRGEAPRIFGDDYPTPDGTCVRDYIHV
                     ADLADAHLAVARKLAGQGAGEDLTVNIGRGEGVSVRQLADLVGEVTGRPVEPVVEARRP
                     GDAARAVASADRMTEELGWTARRGVREMVESAWEGWCLRHPEARAQ"
     aSDomain        complement(1607..2032)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD51_RS16165_NAD_binding_4.1"
                     /evalue="2.50E-10"
                     /label="ASD51_RS16165_NAD_binding_4.1"
                     /locus_tag="ASD51_RS16165"
                     /protein_end="206"
                     /protein_start="64"
                     /score="31.8"
                     /tool="antismash"
                     /translation="HAITGVVHLAAKKQVGESVEKPLLYYRENVTGLAVLLEAVVAAGV
                     RQFLLSSSAAVYGVPDTDLIAEDTPCAPINPYGETKLVGEWMVRAAGRAHGISTACLRY
                     FNVAGTDRPELSDTGVFNVVPMFFDRLTRGEAPRIFGD"
     CDS_motif       complement(2135..2221)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD51_RS16165_0001"
                     /evalue="1.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASD51_RS16165"
                     /protein_end="30"
                     /protein_start="1"
                     /score="17.6"
                     /tool="antismash"
                     /translation="TWLITGGAGYIGAHVARAMTGAGEKVVVL"
     misc_feature    complement(2325..2339)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
     misc_feature    complement(2336..2351)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            2561..4348
                     /locus_tag="ASD51_RS16170"
                     /old_locus_tag="ASD51_07055"
     CDS             2561..4348
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010058029.1"
                     /locus_tag="ASD51_RS16170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07055"
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_056792464.1"
                     /transl_table=11
                     /translation="MRSLGFDVRAATDATEAAELLAAVPASQRVALVDPRFVGHVHALR
                     LGLTDPRFAVATVPGALTAQPEARAAVLGALRTAVAAVGAGVGTGSPVAPPGAEPAAED
                     HTVPGRLAAALDAEGTAVQRPELGSLTAAVPDGPEDRAAVRSAVAAVDDEAVRLRSAVK
                     AHDGFFTTFFISPYSRYIARWCARRGFTPNQVTTASLITALIAAGSAATGTRGGYVAAG
                     VLLLLSFVLDCTDGQLARYSLQYSTMGAWLDATFDRAKEYAYYAGLALGAARGGDDVWV
                     LALGAMVLQACRHVVDFSFNEANHDAVSNTSPTAALSDKLDSVGWTVWLRRMIVLPIGE
                     RWAMIAVLTAVTTPRIVFYALLVGCALAACYTTAGRLLRSLTRKAQRTDRAAGALADLA
                     DSGPLAQAVAAVVRRPGGGFTAPLLALAGALVLVAAALFAPYGSWLTVGAAGVYAVVSG
                     LAVSRPLKGALDWLVPPVFRAAEYCTVLVLAARSDVPHAVPAAFGLVSAVAYHHYDTVY
                     RIRGGTGAPPQWLVRTIGGHEGRTLVVAVLAALLTGASAFTTALTALAAAVALVVLVES
                     IRFWVSSSAPAVHDEGELA"
     gene            4345..5082
                     /locus_tag="ASD51_RS16175"
                     /old_locus_tag="ASD51_07060"
     CDS             4345..5082
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955403.1"
                     /locus_tag="ASD51_RS16175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07060"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_056792465.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.1e-13, bitscore:
                     45.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVDGEKTVLDLTLANFAEV
                     GLTEVAIVVGYRKEAVYARKAEFEATYGVKLTLIDNDKAEEWNNAYSLWCAREVLKQGV
                     ILANGDTVHPVSVERTLLDARGKGQKIILALDTVKNLADEEMKVITEGDQGVRRITKLM
                     DPATATGEYIGVTLIEPEAAEELADALRTTFERDPDLYYEDGYQELVNRGFTVDVAPIG
                     EVTWVEIDNHDDLARGREIACLY"
     gene            5070..6131
                     /locus_tag="ASD51_RS16180"
                     /old_locus_tag="ASD51_07065"
     CDS             5070..6131
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452391.1"
                     /locus_tag="ASD51_RS16180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07065"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_056792466.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.8e-17, bitscore: 58.5,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 4.4e-08, bitscore:
                     27.9, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDIRRGAMDDLAGLLADQRISASGKLAIAISG
                     GSGLALRERLAPVLPGADWYPVGDGTIDSAVRLADGIKGNRYDALVGLGGGKIIDVAKY
                     AAARVGMPMVAVATNLSHDGLCSPVATLDNDNGRGSYGVPTPIAVVIDLDVIREAPARY
                     VRSGIGDAVSNISCVADWELAHEIQGEEIDGLAAAMARQAGEAVLRHPGGVGDDAFLKV
                     LAEGLVLTGISMSVAGDSRPASGGCHEINHAFDLLYPKRAASHGEQVGLGACFAMHLRG
                     AREESLHMASVLRRHGLPVLPGEIGFTPDEFVRAVEYAPQTRPGRFTILEHLNLSTDQI
                     RDAYADYAKAIHS"
     gene            6109..6888
                     /locus_tag="ASD51_RS16185"
                     /old_locus_tag="ASD51_07070"
     CDS             6109..6888
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049651.1"
                     /locus_tag="ASD51_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07070"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_079099267.1"
                     /transl_table=11
                     /translation="MQKPSIAELRPVVHPPGVKDRRSGEHWAGRLYMREISLRITRRLV
                     TTKVTPNQLTYVMTVAGVLAAPALLVPGIPGALLGVVAVQLYLLFDCVDGEVARWKKQY
                     SLGGVYLDRVAAYLCDAAVLVGFGLRAADLWGPGRIDWLWAFLGTLAALGAILIKAETD
                     LVGVARHQGGLPPVKESASEPRSSGMALARRAAGALKFHRLILGIEASLVILVVAVLDT
                     VRDDFFFSRLAVAVMAGIALLQTVLHLVSILASSRLK"
     gene            6885..7769
                     /locus_tag="ASD51_RS16190"
                     /old_locus_tag="ASD51_07075"
     CDS             6885..7769
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983096.1"
                     /locus_tag="ASD51_RS16190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07075"
                     /product="glycosyltransferase"
                     /protein_id="WP_056792468.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.5e-12,
                     bitscore: 42.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPMKIGAVIITMGNRPDELRALLDSVAGQNGDRIEVVVVGNGA
                     PVPDVPAGVRTVELPENLGIPGGRNVGIEAFGASGTDVDVLLFLDDDGLLAKNDTAELC
                     RQAFAADPELGIITFRIADPETGVTQRRHVPRLRAADPMRSSRVTTFLGGANAVRTRVI
                     AEVGPLPDDFFYAHEETDLAWRALDAGWMIDYRADMVLNHPTTAPSRHAVYHRMVARNR
                     VWLARRNLPAPLVPVYVGVWLLLTLVRKPSLPALRAWFGGFREGWTKPCGPRRPMRWRT
                     VWRLTRLGRPPVI"
     gene            7878..8807
                     /locus_tag="ASD51_RS16195"
                     /old_locus_tag="ASD51_07080"
     CDS             7878..8807
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964854.1"
                     /locus_tag="ASD51_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07080"
                     /product="ABC transporter permease"
                     /protein_id="WP_056792469.1"
                     /transl_table=11
                     /translation="MSDTTHDGGIALSSPPSADEGLSASGLAAKYGLTVSGARPGLFAY
                     VRQLWGRRHFILAFSRAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGIILGTSRGMS
                     QEVFVPFLVTGVFVFTFTQSSVMAGVRSIAGNLGLVRALHFPRASLPVSFSLQQLQQLL
                     YSMIVLFAVAIAFGSYPTLSWLLIVPALAMQFLFNTGLALVMARLGSKTPDLAQLMPFV
                     MRTWMYASGVMFSIPVMLADKPQWIADVLQYNPAAVYMDLVRFALIDGYGSENLPQHVW
                     AVGLAWSLLVGVLGFVYFWKAEERYGRG"
     gene            8800..9585
                     /locus_tag="ASD51_RS16200"
                     /old_locus_tag="ASD51_07085"
     CDS             8800..9585
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964853.1"
                     /locus_tag="ASD51_RS16200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07085"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_056792470.1"
                     /transl_table=11
                     /translation="MAEESSQGHIPTVIADDVHIVYRVNGTGGGKGSATAALSRIMRRG
                     KGEPRGVRKVHAVRGVSFTAYRGQAIGLIGTNGSGKSTLLRAIAGLLPTEHGKVYTDGQ
                     PSLLGVNAALMSDLTGERNVVLGGLAMGMSREEIRSRYQDIVDFSGINEKGDFITLPMR
                     TYSSGMAARLRFSIAAAKNHDVLMIDEALATGDRKFRVRSEARIRELRKEAGTVFLVSH
                     NNKTIRDTCDRVLWLERGELLMDGPTEEVLKAYERETGK"
     misc_feature    9723..9736
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     misc_feature    complement(9852..9870)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.52"
                     /tool="antismash"
     gene            10001..10915
                     /gene="hpnC"
                     /locus_tag="ASD51_RS16205"
                     /old_locus_tag="ASD51_07090"
     CDS             10001..10915
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552438.1"
                     /locus_tag="ASD51_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07090"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_056792471.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.1e-37, bitscore:
                     125.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.9e-39,
                     bitscore: 131.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTQQARTDATSTLDKAADENFPVAPFFLPRAWRDDLMAVYGFA
                     RLVDDIGDGDLAPGGADARHLGVGPGTAEDRLALLDALEADLHRVFADAAGGPLHPLMR
                     ALLPTVRRCALTPDPFLGLIEANRQDQKVRRYGTYEELLAYCELSANPVGRLVLQITGT
                     ASPERIRRSDAVCTALQIAEHLQDVTEDLGRDRIYLPAEDMARFHVSESDLAAPTGGAS
                     LRALVAFEAQRAHDLLDEGIPLVGSVRGRLRLLLAGFVGGGRAALTAVAAAGFDVLPGP
                     PKPTAPRLLREVGVVLRKAYREG"
     gene            10924..11865
                     /gene="hpnD"
                     /locus_tag="ASD51_RS16210"
                     /old_locus_tag="ASD51_07095"
     CDS             10924..11865
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450952.1"
                     /locus_tag="ASD51_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07095"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_056792530.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.9e-58, bitscore:
                     193.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6.5e-71,
                     bitscore: 234.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGQTTYMSAPVQAAYSYCEAVTGQQARNFAYGIRLLPYEKRQAM
                     SALYAFSRRVDDIGDGELAPETKRTRLEDTRELLGRIRDGAVDEDDTDPVAVALADAAR
                     RFPLPLGGLDELIDGVLMDVRGASYETWDDLRTYCRCVAGAIGRLSLGVFGTEPGAPGA
                     DRAAEYADTLGLALQLTNILRDVREDAGNGRTYLPADDLAKFGCSAGFHRATPPPGSDF
                     AGLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRV
                     SLPGHEKAYVAVRGLSGLDARYISRRTTRGRA"
     gene            11951..13339
                     /gene="hpnE"
                     /locus_tag="ASD51_RS16215"
                     /old_locus_tag="ASD51_07100"
     CDS             11951..13339
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579669.1"
                     /locus_tag="ASD51_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07100"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_056792472.1"
                     /sec_met_domain="DAO (E-value: 3.6e-10, bitscore: 35.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGQDPRSSRAVVVGGGLAGVTAALRLADAGLDVTLLEGRPRLGG
                     LAFSFRRGELSVDNGQHVFLRCCTAYRWFLDRIEGTHLAPLQERLDVPVLDVGRARGPR
                     LGRLRRTGLPVPLHLAGGLAAYPHLTLAEKAGVARAALALGRLDPADPALDGIDFATWL
                     RRNGQSQRTVEALWDLVGVATLNATAPDASMALAAMVFKTGLLSEPGAADIGWAAVPLG
                     ELHDTLARKALESAGVRLHVRTRAGSLTRTEDGRWAVGTDGSRFEADTVVLAVPQGETH
                     GLLPDGAIDDPGRLLELTDAPILNVHVVYDRKVLRRPFFAALGSPVQWVFDRTATSGLR
                     GGGQYLAVSQSAAQDEIDLPVAELRRRYLPELEKLLPAARGAGVRDFFVTRERTATFAP
                     APGTGRLRPGAHTRAPGLHLAGAWTATGWPATMEGAVRSGFSAADAALHTLGRPHEHPL
                     QEAA"
     gene            13336..14439
                     /locus_tag="ASD51_RS16220"
                     /old_locus_tag="ASD51_07105"
     CDS             13336..14439
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964849.1"
                     /locus_tag="ASD51_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07105"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_056792473.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4e-61, bitscore:
                     201.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTTGTRGESVTPANPAYDTVADTTDVTALLERGRALSTPVLRA
                     AVDRLAPPMDTVAAYHFGWIDAQGRPADGDGGKAVRPALALLSAEAAGAPPEAGIPGAV
                     AVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEILLELGTVE
                     AGRAARRLTTATRKLIDGQAQDISYEHRERVTVEECLEMEGNKTGALLACAVSIGAVLG
                     GADDRTADTLEAYGYHLGLAFQAVDDLLGIWGDPESTGKQTWSDLRQRKKSLPVVAALA
                     AGGPASAQLGELLAADAKSNDFDSFSEEEFAARAALIEEAGGREWTAQEARRQHAVAIE
                     ALHGVDMPEQVRAQLTALADFVVVRKR"
     misc_feature    14447..14463
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            14544..16538
                     /gene="shc"
                     /locus_tag="ASD51_RS16225"
                     /old_locus_tag="ASD51_07110"
     CDS             14544..16538
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152781.1"
                     /locus_tag="ASD51_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07110"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_056792474.1"
                     /sec_met_domain="T2TS (E-value: 2.1e-148, bitscore: 490.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGAANLRAAPVSDPTDTTTAADDVLAAARQAAERSVR
                     HLLGRQDEQGWWKGDLATNVTMDAEDLLLRQFLGIQDPATVKAAARFIRGEQLGDGTWA
                     TFHGGPGDLSATIEGYVALRLAGDRPDDPHMIRAARFVRDRGGIAAARVFTRIWLALFG
                     WWKWDDLPELPPELMFFPKWVPLNIYDFGCWARQTIVPLTVVSAKRPVRPAPFTLDELH
                     TDPARPNPPGRTAPVASWDGVFQRLDKALHLYHKVAPRGLRRIAMNAAARWIIERQEND
                     GCWGGIQPPAVYSVIALHLLGYDLDHPVMRAGLASLDRFTVLREDGARMVEACQSPVWD
                     TCLATIALADAGLSPDHPALVKAADWMLGEEIVRPGDWSVRKPRLAPGGWAFEFHNDNY
                     PDIDDTAEVVLALRRVRHPDPERVEAAIDRGVRWNLGMQSRNGAWGAFDADNTSPFPNR
                     LPFCDFGEVIDPPSADVTGHVVEMLAVEGRSSHPRTRRGIEWLLAEQEASGAWFGRWGV
                     NYIYGTGSVVPALIAAGLPAAHPSVRRAVGWLESVQNEDGGWGEDLRSYQQEEWVGRGA
                     STASQTAWALLALLAAGERDGRPVARGIGWLAGTQQADGSWDEPYFTGTGFPWDFSINY
                     HLYRQVFPLTALGRYVYGDPFATGTGKGA"
     gene            16543..17196
                     /locus_tag="ASD51_RS16230"
                     /old_locus_tag="ASD51_07115"
     CDS             16543..17196
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964847.1"
                     /locus_tag="ASD51_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07115"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_056792475.1"
                     /transl_table=11
                     /translation="MGDARRHPAPVMPLLIACALGIEHLALRTGRGKGGPGPVTVIRTG
                     MGPKAAENAVRRALGQDGVRGAAVIASGFCAGLAPGMHPGDLVVAEETRDDSGTTACTG
                     TGLLVDALTRAVPGRNVHTGPVTGSGHVVRGAERAGLRATGAIAVDMESAATLRTAVRT
                     GPRPVAAVRVVVDAPEYELVRIGTVRGGISAFRVLRAVLPAFHEWHRSLLLPRR"
     gene            17203..18222
                     /gene="hpnH"
                     /locus_tag="ASD51_RS16235"
                     /old_locus_tag="ASD51_07120"
     CDS             17203..18222
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128938.1"
                     /locus_tag="ASD51_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD51_07120"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_056792476.1"
                     /sec_met_domain="PF04055 (E-value: 6.4e-18, bitscore: 61.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-09, bitscore: 33.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIKVATYLIEQKLRKRDKFPLIVELEPLFACNLACEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKKKYVF
                     LCTNAMLMRKKLEKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAMKEAKRRGF
                     RVTTNSTFFNTDTPQTIIEVLNYLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FKKSFAGGNRARWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEETDWEKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAARETIGGNR"
     gene            18227..>18415
                     /locus_tag="ASD51_RS36260"
     CDS             18227..>18415
                     /EC_number="1.17.7.3"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981498.1"
                     /locus_tag="ASD51_RS36260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_206780113.1"
                     /transl_table=11
                     /translation="MTAGEPVALGLPALPARPLAVRRPSRRIQVGSVAVGGDAPVSVQS
                     MTTTRTSDIGATLQQIAE"
     assembly_gap    18416
                     /estimated_length=1
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <18417..>19444
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="ASD51_RS16240"
                     /old_locus_tag="ASD51_07125"
                     /pseudo=""
     CDS             18417..>19444
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031167.1"
                     /locus_tag="ASD51_RS16240"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="ASD51_07125"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQVGSVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIV
                     RVACPTQDDADALSTIARKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDK
                     VKEIAKAAGDAGTPIRIGVNAGSLDARLLRKYGKATPEALVESALWEASLFEEHGFRDI
                     KISVKHNDPVVMVNAYRQLAAQSDYPLHLGVTEAGPAFQGTIKSAVAFGALLSEGIGDT
                     IRVSLSAPPVEEVKVGLQILEALNLKQRRLEIVSCPSCGRAQVDVYKLADQVSAGLDGL
                     EVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAM
                     KI"
ORIGIN
        1 aacccgggag atgaggaagg accggtggct gcgccgggca gcagtcgtct ggacagtcat
       61 caacctcagc tccttctcac ttcgggtccg ggtgcacgga cgtgacggcg gaaccctagc
      121 accggccggc cgggctcagt ggcagagtct cgcctcgtgc tccgcgtgcc cgctcggctc
      181 cagctggaag gtgcagtgct cgacgtcgaa gtgcacgccc aggcagccct gcagatcgtg
      241 caggagcttc tcgtgcccga tcgagtccag catctcctgg tggacgacca cgtgcgcgga
      301 gagcacgggc atgccggagg tgatggtcca ggcatgcagg tcgtggacgt ccagcacacc
      361 cggcagggcc gtgatgtggg cgcgcacctc ttccatgtcg acgcccttgg gggccgactc
      421 cagcagcacg ttgagcgtct cgcgcaggag cttcaccgtc cgcgggacga tcatgaggcc
      481 gatcagcagc gaggcgatcg ggtcggcggc ctgccagccg gtggccatga tgatgcccgc
      541 cgagacgagc accgtgaccg agccgagagt gtccgcgacc acctccagat aggcaccccg
      601 cacgttgagg ctgtccttct gcccgcgcat cagcagggac agggagacga cgttggcgac
      661 caggccgacg gcggcgaacg cgatggccag accgccctgg gtctcggccg gggtgatgaa
      721 gcggtcgacg gcctcgaaga ccagataacc gccgaccccc aggagcagca gacagttggc
      781 cagtgccgcc aggatctcgg cacgggcgaa gccgaaggtg cggttgggcc cggccggccg
      841 gttggcgaag tggatcgcga gcagggccat accgaggccg agcgcgtcgg tcgccatgtg
      901 ggccgcgtcc gcgatcaggg cgagcgagtc ggagagcagc ccgccgatga tctccatgac
      961 catgacgccg agcgtgatgc ccagcgcgac cctgagccgg cccttgtacg cggcggcggc
     1021 cgtgcccgtc gggggcggcc ctccgtgcgt gtgcccgtga tcgtggccag cccccatgga
     1081 acgcctccgg aacgcgtcgt acccctcggg cgccgaccgc ccgatgtggc cagtgaacta
     1141 cgggcggggg gtaccgggca acacggcatt gaacaccgtt gtcatgtgct ctgacctgcg
     1201 gaaacgttcg caggtcagag catcggcccg gggtcgcgga tcactgggcg cgggcctccg
     1261 ggtggcgcag gcaccagccc tcccacgccg actcgaccat ctcgcgcacc ccgcgccggg
     1321 ccgtccaccc cagctcctcg gtcatgcggt cggcggacgc gacggcacgg gccgcgtccc
     1381 ccggcctgcg cgcctcgacc acgggctcca cgggacggcc ggtgacctcg cccaccaggt
     1441 cggcgagctg ccgcaccgat acgccctcac cgcggccgat gttcacggtc aggtcctcgc
     1501 cggcgccctg accggccagc ttccgcgcca cagcgagatg cgcgtcggcc agatcggcga
     1561 cgtggatgta gtcgcggaca caggtgccgt ccggcgtcgg gtagtcgtca ccgaagatcc
     1621 gcggtgcctc accgcgcgtc agcctgtcga agaacatcgg gacgacgttg aagacacctg
     1681 tgtcggacag ctcgggccgg tcggtacccg ccacgttgaa gtaccgcaga caggctgtgg
     1741 agatcccgtg tgcccgcccc gcggcccgca ccatccactc gcccacgagc ttggtctcgc
     1801 cgtacgggtt gatgggcgcg cacggggtgt cctccgcgat gaggtccgtg tccggcacgc
     1861 cgtacaccgc cgccgacgag gagaggagga actgccgcac accggccgcg accacggcct
     1921 ccagcagcac ggcgagcccg gtgacgttct cccggtagta gagcagcggc ttctccacgg
     1981 actcgccgac ctgcttcttc gccgcgagat gcaccacacc cgtgatcgcg tgctcggcca
     2041 gcacccggtc gagcagcccg cggtcgtggg cggaaccgcg caccagctcg atgtccgcgg
     2101 gcagccggcc ggcgataccc gtcgagatgt cgtcgaggac gacgaccttc tccccggccc
     2161 ccgtcatggc cctcgccacg tgtgccccga tgtaaccggc cccgcctgtg atcaaccacg
     2221 tcatacgcgt cagcttaggc cgaccggtgg gggacccgcc gcgtacctcc ccccgcccgg
     2281 ccgcccgacc gcgggcggga cgcggtttgt ggggcggggc atcgatcgac gatgatgatc
     2341 gcgaacggcg ccgcatcatg gccgcttcac ccgaacggag cacaaacggg tggtgaactc
     2401 ggccttccgt tcatccgata gcctcagccg atgcgccccg ccggcccgtc tccgggccgc
     2461 actgtcgcgg gctgttcccg tcagcaccaa ggagtgagtt cgtctgtcga ccgccatcct
     2521 caccggtgcg ccggtacccg gatcgtcgct cgaggacgat ctgcggtcac tcggctttga
     2581 tgtaagggcc gccaccgacg cgaccgaggc cgccgaactg ctcgccgcgg ttcccgcgag
     2641 ccagcgcgtc gcgctcgtgg acccccgctt cgtcggccac gtccatgccc tcaggctcgg
     2701 actgaccgac ccccgcttcg ccgtcgccac cgtgcccgga gcgctcaccg cgcagcccga
     2761 ggcacgggcc gcggtgctgg gcgccctgcg cacggcggtg gccgccgtcg gcgcgggcgt
     2821 cggcacggga agccccgtcg cgcccccggg cgccgaaccc gccgccgagg accacacggt
     2881 ccccggccgc ctcgccgcgg ccctggacgc cgagggcacc gccgtgcagc gtcccgagct
     2941 cggctcgctc accgccgcgg tacccgacgg ccccgaggac cgcgctgccg tccggtccgc
     3001 cgtcgccgct gtcgacgacg aggcggtacg gctgcgcagc gccgtgaagg cccacgacgg
     3061 gttcttcacc acgttcttca tcagcccgta ctcccgctac atcgcccgct ggtgcgcccg
     3121 ccggggcttc accccgaacc aggtcaccac cgcctccctg atcaccgccc tgatcgcggc
     3181 gggcagcgcg gcgaccggca cccgaggcgg ctacgtcgcg gccggggtgc tgctgctcct
     3241 ctccttcgtc ctggactgca ccgacgggca gctcgcccgc tactcgctgc agtactcgac
     3301 gatgggcgcc tggctggacg ccaccttcga ccgggccaag gagtacgcgt actacgcggg
     3361 tctcgcgctc ggcgccgccc gcggcggcga cgacgtatgg gtcctcgcgc tcggcgcgat
     3421 ggtcctccag gcctgccgcc atgtcgtcga cttctcgttc aacgaggcca accacgacgc
     3481 ggtctccaac acgagtccca ccgccgcgct ctccgacaag ctcgacagcg tcggctggac
     3541 ggtctggctg cgccggatga tagtgctgcc catcggcgag cgctgggcca tgatcgccgt
     3601 gctgaccgcg gtgacgaccc cccggatcgt cttctacgcc ctcctcgtgg gctgcgccct
     3661 ggccgcctgc tacaccacgg ccggccgact gctccgctcg ctgacccgca aggcgcagcg
     3721 caccgaccgg gcagcgggtg cactggccga cctcgccgac tcggggcccc tcgcgcaggc
     3781 cgtcgccgcc gtggtccggc gtccgggcgg cggcttcacc gccccgctgc tggcgctcgc
     3841 cggagccctg gtgctggtcg ccgccgcact cttcgcgccc tacggcagct ggctgaccgt
     3901 cggcgcggca ggggtgtacg cggtcgtctc cggcctcgcg gtctcacggc cgctcaaggg
     3961 cgccctcgac tggctggtgc ccccggtctt ccgggccgcg gagtactgca cggtcctcgt
     4021 cctggcggcc cgcagcgacg taccgcacgc cgttccggcg gcattcggcc tggtttcggc
     4081 cgtcgcctac catcactacg acacggtcta ccgcatccga ggcggtacgg gcgccccgcc
     4141 ccagtggctg gtgcgcacca tcggcgggca cgagggccgg accctggtcg tggccgtact
     4201 cgccgccctg ctgaccggag cctcagcttt caccacggct ctgaccgcgc tggcggcggc
     4261 cgtggctctg gtggtgctcg tggagtccat ccgcttctgg gtgtcctcct cggcccccgc
     4321 cgtacacgac gaaggagaac tcgcatgatc ggcctcgtac tggctgccgg tgccggacgc
     4381 cgtctgcgtc cctacacgga caccctgccc aaggcgctgg tgcccgtcga cggcgagaag
     4441 acggtcctcg acctgacgct cgccaacttc gccgaggtcg gactcaccga ggtcgcgatc
     4501 gtcgtcggct accgcaagga agcggtctac gcccgcaagg ccgagttcga ggccacgtac
     4561 ggcgtgaagc tgaccctgat cgacaacgac aaggccgagg agtggaacaa cgcctactcc
     4621 ctctggtgcg cccgtgaggt cctgaagcag ggcgtcatcc tcgccaacgg cgacaccgtg
     4681 cacccggtct ccgtcgagag gaccctgctg gacgcccgcg gcaagggcca gaagatcatc
     4741 ctcgccctcg acacggtgaa gaacctcgcc gacgaggaga tgaaggtcat caccgagggc
     4801 gaccagggcg tccggcggat caccaagctg atggaccccg ccaccgcgac cggcgagtac
     4861 atcggcgtca cgctgatcga gcccgaggcc gccgaggagc tcgccgacgc gctgaggacc
     4921 accttcgagc gcgaccccga cctctactac gaggacggct accaggagct cgtgaaccgc
     4981 ggcttcacgg tcgacgtcgc ccccatcgga gaggtcacgt gggtcgagat cgacaaccac
     5041 gacgacctcg cccggggcag ggagatcgcg tgcctgtact gacgcgcctc atcccgtccc
     5101 cggtcgtcgt cgacatccgt cgcggcgcga tggacgatct ggccggtctc ctcgccgacc
     5161 agcggatctc cgcgtcgggc aagctcgcca tcgcgatcag cggaggttcc ggactcgccc
     5221 tccgcgagag gctcgcgccg gtgctgccgg gggccgactg gtaccccgtc ggcgacggca
     5281 cgatcgactc cgcggtgcgg ctcgccgacg gcatcaaggg caaccgctac gacgccctcg
     5341 tcggcctcgg cggcggaaag atcatcgacg tggccaagta cgccgcggcg cgggtcggca
     5401 tgcccatggt cgccgtcgcg acgaacctgt cccacgacgg gctctgctcc ccggtcgcga
     5461 ccctggacaa cgacaacgga cgcggctcct acggggtccc caccccgatc gccgtggtca
     5521 tcgacctgga cgtgatccgc gaggcccccg cgcgctacgt gcgctcgggc atcggggacg
     5581 cggtctccaa catctcctgc gtcgccgact gggagctggc ccacgagatc cagggcgagg
     5641 agatcgacgg actcgccgcc gccatggccc ggcaggcggg cgaggcagtg ctgcgtcacc
     5701 ccggcggggt cggcgacgac gccttcctca aggtgctggc cgagggcctc gtcctgaccg
     5761 gcatctcgat gtcggtcgcc ggggactccc ggccagcctc gggcggctgc cacgagatca
     5821 accacgcctt cgacctgctg tacccgaagc gcgcggcaag ccacggcgag caggtcggcc
     5881 tcggcgcctg cttcgccatg cacctgcggg gcgcccgcga ggagtcgctg cacatggctt
     5941 ccgtactgcg gcgccacggg ctgccggtgc tgcccggcga gatcgggttc acccccgacg
     6001 agttcgtgcg ggccgtcgag tacgccccgc agacgcgccc gggacgcttc acgatcctgg
     6061 aacacctcaa cctgtccacc gaccagatca gggacgcgta cgccgactat gcaaaagcca
     6121 tccatagctg aactccgtcc ggtcgtgcac cctccgggtg tgaaggaccg gcgcagcggc
     6181 gagcactggg cgggtcggct ctacatgcgc gagatctcgc tgcgcatcac ccggcgcctg
     6241 gtgaccacca aggtcacgcc caaccagctg acctacgtga tgaccgtcgc cggtgtgctc
     6301 gcggctccgg ctctgctggt cccgggcatc ccgggcgcgc tgctcggcgt ggtcgcggtc
     6361 cagctctacc tgctgttcga ctgcgtcgac ggcgaggtgg cgcggtggaa gaagcagtac
     6421 tccctgggcg gggtctacct ggaccgggtg gccgcctatc tctgtgacgc ggcggtgctg
     6481 gtcggcttcg gcctgcgtgc cgccgacctg tggggcccgg ggcgcatcga ctggctgtgg
     6541 gccttcctgg gcacgctcgc cgcgctgggc gccatcctga tcaaggccga gaccgacctc
     6601 gtcggcgtcg cccgccacca aggcgggctg ccccccgtca aggaatccgc gtccgagccg
     6661 cgctcctccg gcatggcgct ggcccgccgg gcggccggtg cgctcaagtt ccaccggctg
     6721 atcctcggca tcgaggcgtc gctggtcatc ctggtggtgg ccgtgctcga caccgtcagg
     6781 gacgacttct tcttcagccg tctcgcggtc gcggtcatgg ccggcatcgc ccttctccag
     6841 accgtcctgc acctggtgtc gatcctggcg tccagcaggc tgaagtgagc tcacccatga
     6901 aaatcggcgc agtcatcatc accatgggca accggcccga cgagctgcgt gccctcctcg
     6961 actcggtcgc cgggcagaac ggcgaccgga tcgaggtggt cgtcgtcggc aacggcgccc
     7021 cggtccccga cgtgcccgcg ggtgtgcgga ccgtggagct gcccgagaac ctgggcatcc
     7081 ccggcggacg caacgtcggc atcgaggcgt tcggcgcctc cggcaccgac gtggacgtgc
     7141 tgctgttcct cgacgacgac gggctgctgg cgaagaacga cacagccgag ctgtgccggc
     7201 aggcgttcgc ggcggacccg gagctcggca tcatcacctt ccgcatcgcc gaccccgaga
     7261 ccggggtcac ccagcgccgg cacgtcccgc ggctgcgtgc ggcagacccg atgcgctcct
     7321 cccgcgtgac gacgttcctc ggcggggcca acgcggtgcg tacccgggtg atcgccgagg
     7381 tcggcccgct ccccgacgac ttcttctacg cacacgagga gaccgacctc gcctggcggg
     7441 ccctcgacgc cggctggatg atcgactacc gcgcggacat ggtgctcaac caccccacca
     7501 ccgccccgtc acggcacgcg gtctaccacc gcatggtggc ccgcaaccgg gtctggctgg
     7561 cccgccggaa cctgccggca ccgctggtcc ccgtgtacgt cggggtctgg ctgctgctca
     7621 cgctggtgcg caagccctcc ctgcccgcgc tgagggcgtg gttcggcggt ttccgggaag
     7681 ggtggacgaa gccctgcgga ccccggcgcc ccatgaggtg gcgtacggtg tggcgcctga
     7741 ccagactggg ccgaccgcct gtgatctgag aggctctcct ctgagaccat gagccctgtt
     7801 tcgttgtgta cggggacctg tccgcctcgg ccgcacccgc gtccggctgc gcattgtgaa
     7861 gacgagagtt cttacctgtg agtgatacga cccacgacgg cgggattgcg ctgagcagcc
     7921 cgccgtccgc cgacgagggg ctgagtgcct ccgggctggc cgccaagtac ggcttgacgg
     7981 tgagcggcgc caggcccggg ctgttcgcgt acgtccggca gctctggggc cgccggcact
     8041 tcatcctggc gttctccagg gccaagctga ccgcgcagta cagccaggcc aagctcggcc
     8101 agctgtggca ggtcgccacc ccgctgctga acgccctcgt ctacttcctg atcttcggga
     8161 tcatcctcgg caccagcagg gggatgagcc aggaggtctt cgtcccgttc ctggtcacgg
     8221 gtgtgtttgt cttcaccttc acccagagct cggtcatggc gggggtgcgg tccatcgccg
     8281 gcaacctcgg cctggtcagg gccctgcact tcccgcgtgc ctcgctgccc gtctcgttct
     8341 cgctccagca gctccagcag ctgctgtact cgatgatcgt gctgttcgcc gtggcgatcg
     8401 ccttcggcag ctatcccacg ctctcgtggc tcctgatcgt cccggcgctc gccatgcagt
     8461 tcctgttcaa caccggcctg gcgctcgtca tggcccggct gggcagcaag accccggacc
     8521 tcgcgcagct gatgccgttc gtcatgcgta cctggatgta cgcctcgggc gtcatgttct
     8581 ccatcccggt gatgctggcc gacaagccgc agtggatcgc ggacgtgctg cagtacaacc
     8641 ccgcggccgt ctacatggac ctggtccgct tcgcgctgat cgacggctac ggctccgaga
     8701 acctgccgca gcacgtctgg gccgtgggac tcgcctggtc gctcctggtg ggcgtcctgg
     8761 gcttcgtgta cttctggaag gcagaggaac ggtacggccg tggctgagga atcttcccag
     8821 ggacacatcc ccaccgtgat cgccgacgac gtacacatcg tgtaccgggt caacgggacg
     8881 gggggcggca agggcagcgc caccgcggcg ctcagccgga tcatgcgccg cggcaagggc
     8941 gagccgcgcg gcgtccgcaa ggtgcacgcg gtgcgggggg tctccttcac cgcctaccgt
     9001 ggtcaggcca tcggcctcat cggcaccaac ggctcgggca agtccaccct gctccgggcc
     9061 atcgccgggc tgctgccgac cgagcacggc aaggtgtaca cggacggcca gccctcgctg
     9121 ctgggtgtca acgccgcgct gatgagcgac ctgaccggtg agcgcaacgt cgtgctcggc
     9181 ggcctcgcga tggggatgag ccgcgaggag atccgctcgc gctaccagga catcgtcgac
     9241 ttctcgggga tcaacgagaa gggcgacttc atcacgctgc ccatgcggac gtactcctcg
     9301 ggcatggcgg cgcgactgcg cttctcgatc gcggcggcca agaaccacga cgtcctcatg
     9361 atcgacgagg cgctggccac cggtgaccgc aagttccggg tccgctccga ggcgcggatc
     9421 cgcgagctgc gcaaggaggc gggcaccgtc ttcctcgtca gccacaacaa caagaccatc
     9481 cgggacacct gcgaccgggt gctgtggctg gagcggggcg agctcctgat ggacggcccc
     9541 accgaagagg tgctcaaggc gtacgagcgg gagaccggca agtaggtccc tccgttcccg
     9601 tggcccccgc cggtgcaccg aggcgggggc cactgcggtg cgtggtggcc cgggtcgcgg
     9661 ggacgccagg gggggtatct cctcccgtcg gatgacgtca attaccttga tcccggggaa
     9721 ggttgacgga gatcgaagtg ttgtgccggg acgcgccgca ccccggcgcg gccccgtgag
     9781 ctgtacaacg taagctgtgc gggagctgat tcgcggccat gtggggtgat acgccccccg
     9841 gtgcatcggc cgttgtgagc ctgtcgcact cggggcagtg agcggcgtgt ccgaaaaggg
     9901 atgttttggg tcagcagtgt agaacgggag atatgacggc aatgatggga aatctccagc
     9961 tccgacgtgg tttcgccgtc cccgcgtcgg gcggtacgca gtgacccgta cgcagcaggc
    10021 gcgtaccgac gccacctcca ccctcgacaa ggccgcggac gagaacttcc ccgtggcccc
    10081 cttcttcctg ccccgcgcct ggcgcgacga cctgatggcg gtctacggct tcgcccgcct
    10141 cgtcgacgac atcggtgacg gcgacctcgc gcccggcggt gcggacgccc gccacctcgg
    10201 cgtcggcccc ggcacggccg aggaccggct cgccctgctc gacgccctcg aggccgatct
    10261 gcaccgcgtc ttcgcggacg ccgcaggcgg cccgctccac cccctgatgc gcgccctgct
    10321 ccccaccgtg cggcgctgcg ccctcacccc cgatcccttc ctcgggctca tcgaggccaa
    10381 ccggcaggac cagaaggtcc gccgctacgg gacgtacgaa gagctcctcg cctactgcga
    10441 gctctcggcc aaccccgtcg gacgcctcgt cctgcagatc accggtaccg cgagtcccga
    10501 acggatccgc cgctccgacg ccgtctgcac cgcgctgcag atcgccgagc acctccagga
    10561 cgtcacggag gacctcggcc gggaccggat ctacctgccc gcggaggaca tggcccgctt
    10621 ccacgtctcc gaatccgacc tggccgcacc gaccggggga gcgtcgctgc gcgccctggt
    10681 cgcgttcgag gcgcagcgtg cccacgacct gctggacgag gggatccctc tggtgggcag
    10741 cgtccggggc aggctcaggc tcctgctcgc cggcttcgtc ggcggagggc gggcagcgct
    10801 caccgccgtc gccgccgccg gattcgacgt actgcccgga ccgcccaagc ccaccgcgcc
    10861 gcgtctgctg cgcgaagtgg gagtagtcct gcgaaaagcg tacagagagg ggtgagccgg
    10921 accgtggagg gacagacgac gtacatgtcg gcaccggtac aggccgcgta cagctactgc
    10981 gaggccgtca ccggacaaca ggcccgtaac ttcgcctacg gcatcagact gctgccgtac
    11041 gagaagcggc aggccatgtc ggcgctgtac gccttctccc gccgcgtcga cgacatcggc
    11101 gacggcgagc tggccccgga gaccaagcgg acccggctgg aggacacccg cgagctcctc
    11161 ggccggatcc gcgacggcgc ggtcgacgag gacgacaccg acccggtggc cgtcgcgctg
    11221 gcggacgccg cgcgccggtt cccgctgccg ctcggcggcc tcgacgagct gatcgacggc
    11281 gtcctcatgg acgtgcgcgg tgcgagctac gagacctggg acgacctcag gacctactgc
    11341 cggtgcgtcg cgggcgccat cgggcggctc agcctcggtg tcttcggcac ggaacccggc
    11401 gcacccgggg ccgaccgggc cgcggagtac gccgacaccc tcggcctcgc actccagctc
    11461 accaacatcc tccgcgacgt ccgtgaggac gcgggcaacg ggcgcacgta cctgcccgcc
    11521 gacgacctcg ccaagttcgg ctgctccgcc ggcttccacc gggccacccc gccccccggc
    11581 tccgacttcg ccggcctggt gcacttcgag gtccggcgcg cccgcgccct cttcgccgag
    11641 ggctaccggc tgctgcccat gctggaccgg cgcagcggcg cctgcgtggc ggccatggcc
    11701 ggcatctacc gccggctcct cgaccggatc gagcgcgacc ccgaggccgt cctgcgcggc
    11761 agggtttccc tgcccggcca cgagaaggcg tacgtcgccg tgcgcgggct gtcgggcctg
    11821 gacgcgcggt acatctcgcg ccggaccacc cgggggaggg cctgatgcgc ccggtggacc
    11881 acgccgagcg ggcaaccccg cacccgcccc acgcgtccct gagtgcgacg gcgcgacgga
    11941 gggagcacac atgaccggtc aggacccgcg ctcctcgcgt gccgtggtcg tcggcggcgg
    12001 tctcgccgga gtgacggccg ccctgcgcct cgccgacgcc gggctcgacg tgaccctgct
    12061 cgaaggccgc ccccggctgg gaggcctggc cttctccttc cgccgcggcg agctgtccgt
    12121 cgacaacggc cagcacgtct tcctgcgctg ctgcaccgcc taccgctggt tcctggaccg
    12181 catcgaaggc acccacctcg cccccctgca ggagcgtctc gacgtccccg tactcgatgt
    12241 ggggcgggcc cgggggccga ggctcggacg gctgcgccgc accgggctgc ccgtgcccct
    12301 gcacctcgcc ggcgggctcg ccgcctaccc gcacctcacg ctcgccgaga aggcgggcgt
    12361 cgcccgcgcg gcactcgcgc tgggccggct cgacccggcc gaccccgcgc tcgacggcat
    12421 cgacttcgcg acctggctgc gccggaacgg ccagtcgcag cggaccgtcg aggcgctctg
    12481 ggacctcgtc ggcgtcgcca cgctcaacgc caccgccccc gacgcctcca tggcactggc
    12541 cgcgatggtc ttcaagacgg ggctgctctc cgagcccggc gccgccgaca tcggctgggc
    12601 cgccgtgccg ctcggcgagc tgcacgacac cctcgcccgc aaggccctcg agtcggcggg
    12661 cgtacggctc cacgtacgga cccgggccgg ctccctcacc cgcaccgagg acggccggtg
    12721 ggccgtcggg acggacggct cacggttcga ggccgacacc gtcgtcctcg ccgtacctca
    12781 gggcgagacc cacgggctgc tgccggacgg ggcgatcgac gaccccggcc ggctcctgga
    12841 actgaccgac gcgccgatcc tcaacgtgca cgtcgtctac gaccgcaagg tgctgcgccg
    12901 gccgttcttc gccgcgctcg gctcgcccgt gcaatgggtc ttcgaccgca ccgcgacgtc
    12961 cgggctccgg ggcggcgggc agtacctcgc ggtgtcccag tccgcggccc aggacgagat
    13021 cgacctgccc gtcgccgagc tgcgcaggcg ctacctgccc gagctggaga agctcctccc
    13081 cgccgcgcgc ggcgccggtg tccgcgactt cttcgtcacc cgcgagcgca ccgcgacgtt
    13141 cgcacccgct ccggggacgg ggcggctgag gccgggtgcg cacacccgtg cccccggact
    13201 ccatctggca ggcgcatgga ctgccaccgg ctggcccgcc acgatggagg gtgcggtccg
    13261 cagcggtttc agtgccgcgg acgccgcgct ccacaccctc ggacgacccc acgaacatcc
    13321 gctgcaggaa gcggcatgag cagtaccacc ggaacaagag gagagtctgt gaccccggcg
    13381 aatccggctt acgacaccgt ggcggacacc acggacgtca ccgcgcttct ggagcgtgga
    13441 agggccctgt caacgccggt gctgcgagct gccgtggacc ggctggcgcc gcccatggac
    13501 accgtcgcgg cgtaccactt cggctggatc gacgcccagg gccggccggc cgacggcgac
    13561 ggcggcaagg ccgtgcgccc cgcgctcgcc ctgctgtccg cggaagccgc gggcgctccg
    13621 cccgaggccg gcatccccgg cgccgtcgcc gtcgaactcg tgcacaactt ctcgctgctg
    13681 cacgacgacc tgatggacgg cgacgagcag cgccgccacc gggacaccgt gtggaaggtg
    13741 cacgggccgg cccaggccat cctcgtcggc gacgcgctct tcgcgctggc caacgagatc
    13801 ctgctggagc tcggcaccgt cgaggccggc cgggcggccc gccggctgac caccgccacc
    13861 cgcaagctca tcgacgggca ggcccaggac atctcctacg agcaccgcga gcgggtcacc
    13921 gtcgaggagt gcctggagat ggagggcaac aagacgggcg cgctgctcgc ctgcgccgtg
    13981 tccatcggag cggtgctcgg cggcgccgac gaccgcaccg ccgacacact ggaggcgtac
    14041 ggctaccacc tcggcctcgc cttccaggcc gtcgacgacc tgctcgggat ctggggagac
    14101 ccggagtcca cgggcaagca gacctggagt gatctgcgcc agcgcaagaa gtccctgccc
    14161 gtcgtcgccg cgctcgccgc gggcggaccg gcctccgccc agctgggcga gctgctggcc
    14221 gccgacgcca agagcaacga cttcgacagc ttctccgagg aggagttcgc cgcacgcgcg
    14281 gcactcatcg aggaggcggg cggccgggag tggaccgccc aggaagcccg tcgtcagcac
    14341 gccgtggcca tcgaggcact gcacggcgtc gacatgccgg aacaggtacg ggcacagctc
    14401 accgcacttg ccgacttcgt cgtcgtacga aagagatgat caccattcgc atatgactcg
    14461 cagtcgccgg cgggtgccct gaccgggcac ccgccgacgg agaccccagc acagcagcgg
    14521 accaactgca cgaaggggaa gccatgacag cgacgaccga cggaagcacc ggagccgcga
    14581 acctccgcgc agccccggta agcgatccga ccgacacgac cactgccgcg gacgatgtgc
    14641 tcgccgccgc gcggcaggcc gcggaacgct cggtgcggca cctcctcggc aggcaggacg
    14701 agcagggctg gtggaagggg gacctcgcca ccaacgtcac gatggacgcc gaggacctgc
    14761 tgctccgtca gttcctgggc atccaggacc cggccaccgt gaaggcggca gcccgcttca
    14821 tccgcggcga gcaactgggc gacggaacct gggcgacctt ccacggcggt cccggcgacc
    14881 tctccgccac catcgagggg tacgtcgcgc tccggctggc cggagaccgg ccggacgacc
    14941 cgcacatgat ccgtgcggcc cgcttcgtcc gggaccgggg aggcatcgcg gcagcccggg
    15001 tcttcacccg catctggctc gcgctcttcg gctggtggaa gtgggacgac ctgcccgagc
    15061 tcccgcccga gctcatgttc ttcccgaagt gggtcccgct caacatctac gacttcggct
    15121 gctgggcccg tcagaccatc gtcccgctca ccgtcgtctc cgcgaagcgg cccgtccgcc
    15181 ccgccccgtt caccctcgac gagctgcaca ccgaccccgc ccgcccgaac cctcccgggc
    15241 gtacggctcc ggtggccagc tgggacggcg tcttccagcg gctcgacaag gcactgcacc
    15301 tctaccacaa ggtcgccccg cgcggactgc ggcgcatcgc catgaacgcg gcggcccgct
    15361 ggatcatcga gcgccaggag aacgacgggt gctggggcgg gatccagccg cccgccgtct
    15421 actccgtcat cgccctgcac ctgctgggct acgacctcga ccacccggtg atgcgcgccg
    15481 gactcgcctc gctcgaccgg ttcaccgtcc tgcgcgagga cggcgcccgt atggtcgaag
    15541 cctgccagtc accggtctgg gacacctgcc tcgccaccat cgcgctcgcc gacgccgggc
    15601 tgagccccga ccacccggcc ctcgtgaagg ccgccgactg gatgctgggc gaggagatcg
    15661 tacggccggg cgactggtcg gtgcgcaagc cccgactggc cccggggggg tgggcgttcg
    15721 agttccacaa cgacaactac cccgacatcg acgacaccgc ggaagtcgtc ctcgcgctgc
    15781 gccgggtgcg tcaccccgac cccgagaggg tcgaggccgc gatcgaccgc ggggtgcgct
    15841 ggaacctcgg catgcagtcc cgcaacggcg cctggggcgc cttcgacgcg gacaacacca
    15901 gccccttccc caatcggctg ccgttctgcg acttcggcga ggtcatcgat ccgccgtccg
    15961 ccgacgtcac cgggcacgtg gtggagatgc tcgccgtcga ggggcgttcg agccaccccc
    16021 gcacccgccg cggcatcgag tggctgctcg ccgaacagga ggcgagcggt gcgtggttcg
    16081 gcagatgggg cgtcaactac atctacggca ccgggtccgt ggtgccggcc ctgatcgcgg
    16141 ccgggctgcc cgcggcgcac ccctccgtcc ggcgggccgt cggatggctg gagtccgtcc
    16201 agaacgagga cggcggctgg ggcgaggacc tgcgctccta ccagcaggag gagtgggtcg
    16261 gacgcggtgc gtcgaccgcc tcccagaccg cttgggcact cctcgcactc ctcgcggccg
    16321 gggagcgcga cggcaggccc gtcgcgaggg gaatcggctg gctggcgggg acccagcagg
    16381 ccgacggctc gtgggacgag ccctacttca ccgggaccgg cttcccctgg gacttctcca
    16441 tcaactacca cctctaccgg caggtgttcc ccctcaccgc cctcggccgg tacgtctacg
    16501 gcgacccgtt cgccaccggt accggcaagg gggcctgacc ggatgggcga tgcccggagg
    16561 caccccgccc ccgtcatgcc actgctcatc gcctgcgcgc tcggcatcga gcacctcgcc
    16621 ctgcgcacgg gcagggggaa gggcggcccc ggcccggtga ccgtcatcag aaccgggatg
    16681 ggtcccaagg ccgcggagaa cgccgtccgc cgggcgctgg gacaggacgg ggtccggggc
    16741 gccgcggtca tcgcctcggg cttctgcgcg gggctggccc ccggcatgca ccccggtgac
    16801 ctcgtggtgg ccgaggagac ccgggacgac agcggcacga cggcctgtac ggggacgggt
    16861 ctgctggtcg acgcgctgac cagagcggta ccgggccgca acgtccacac cgggccggtg
    16921 accggctccg gtcacgtcgt ccggggtgcc gaacgcgccg ggctccgggc caccggagcc
    16981 atcgcggtgg acatggagtc cgccgccacg ctccgcaccg ctgtacggac cggcccccgc
    17041 ccggttgcgg ccgtacgagt ggtcgtggac gctcctgagt acgagctcgt ccgtatcggc
    17101 acggtccgcg gtggaatatc ggcattccgt gttcttcgtg ctgtccttcc ggctttccat
    17161 gaatggcacc gatctttgct gctccccagg aggtgagccc agatggccat gccgctccgt
    17221 cagtccatca aggttgcgac gtatctgatc gaacagaagc tccgcaagcg ggacaagttc
    17281 ccgctgatcg tcgagctgga gcccttgttc gcctgcaatc tggcgtgtga gggctgtggg
    17341 aagatccagc acccggccgg ggtgctcaag cagcgcatgc cggtcgccca ggcggtcggg
    17401 gcggtgctcg aatcgggcgc cccgatggtg tccatcgccg gtggggaacc gctgatgcac
    17461 ccccagatcg acgagatcgt gcgtcagctg gtggcgaaga agaagtacgt cttcctctgc
    17521 accaacgcca tgctgatgcg taagaagctc gagaagttca cgccgtcgcc gtacttcgcc
    17581 ttcgccgtgc acatcgacgg actgcgcgag cggcacgacg agtccgtcgc caaggaaggt
    17641 gtcttcgacg aggcggtgga ggcgatgaag gaggccaagc ggcgcggctt ccgggtcacc
    17701 accaactcca ccttcttcaa caccgacacc ccccagacca tcatcgaggt cctcaactac
    17761 ctcaacgacg acctgaaggt cgacgagatg atgatctcgc ccgcgtacgc ctacgagaag
    17821 gcacccgatc aggagcactt cctgggcgtg gagcagaccc gcgagctctt caagaagtcc
    17881 ttcgccggcg ggaacagggc ccgctggcgc ctgaaccact cgccgctctt cctggacttc
    17941 ctggagggca aggcggactt cccgtgcacg gcctgggcga tccccaacta ctcgctcttc
    18001 ggatggcagc gtccctgcta cctgatgagc gacgggtacg tccccacgta ccgggagctc
    18061 atcgaggaga ccgactggga gaagtacgga cgcggcaagg acccgcggtg cgccaactgc
    18121 atggcgcact gcggctacga gccgaccgcc gtcctcgcca ccatggggtc gctgaaggag
    18181 tccctgcggg cggcgcggga gaccatcggc gggaaccggt gacgccatga ccgcgggaga
    18241 gccggtcgcg ctgggtctcc ccgcgctgcc ggcccggccg ctcgcggtgc gccgcccctc
    18301 acggcgcatc caggtcgggt cggtggcggt cggtggggat gctcccgtgt cggtgcagtc
    18361 gatgacgacg acgcgtacgt cggacatcgg tgcgacgttg cagcagatcg cggagnatcc
    18421 aggtcgggtc ggtggcggtc ggtggggatg ctcccgtgtc ggtgcagtcg atgacgacga
    18481 cgcgtacgtc ggacatcggt gcgacgttgc agcagatcgc ggagctgacg gcgtcgggct
    18541 gtcagatcgt gcgggtggcg tgtccgacgc aggacgacgc ggacgcgttg tcgacgatng
    18601 cgcggaagtc gcagatcccg gtgatcgcgg acattcattt ccagccgaag tacgtgttcg
    18661 cngcgatnga cgcggggtgt gcggcggtgc gggtgaatcc gggcaacatc aagcagttcg
    18721 acgacaaggt caaggagatc gcgaaggctg ccggggatgc ggggacgccg atccggatcg
    18781 gtgtgaacgc gggttccctg gangcgcggc tgntgcggaa gtacgggaag gcgacgccgg
    18841 aggctctggt ggagtcggcg ctgtgggagg cgtcgctgtt cgaggagcac gggttccggg
    18901 acatcaagat ctcggtgaag cacaacgacc cggtcgtgat ggtgaacgcc taccgtcagc
    18961 tggccgcgca gtccgactac ccgctgcatc tgggtgtgac cgaggccggc cccgcgttcc
    19021 aggggacgat caagtccgcg gtggcgttcg gtgcgctgct gtcggagggg atcggggaca
    19081 cgatccgggt gtcgttgtcg gctcctccgg tggaggaggt caaggtgggt ctgcagatcc
    19141 tggaggcgct gaatctgaag cagcggcgtc tggagatcgt gtcgtgtccg tcgtgcgggc
    19201 gggcgcaggt ggatgtgtac aagctggcgg atcaggtcag tgcggggctg gacggtctgg
    19261 aggtcccgct gcgggtcgcg gtgatgggct gtgtcgtgaa cggtccgggt gaggcccgtg
    19321 aggctgatct gggtgtggcg tcgggcaacg gcaagggcca gatcttcgtg aagggcgagg
    19381 tcatcaagac cgtcccggag tcgaagatcg tggagaccct catcgaggaa gccatgaaga
    19441 tcgc
//
