LOCUS       NZ_LMEU01000015        11293 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces sp. Root1319 contig_22, whole genome shotgun sequence.
ACCESSION   NZ_LMEU01000015
VERSION     NZ_LMEU01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1319
  ORGANISM  Streptomyces sp. Root1319
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 364537)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 364537)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1319
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426615.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 02:19:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,915
            CDSs (total)                      :: 5,857
            Genes (coding)                    :: 5,667
            CDSs (with protein)               :: 5,667
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 1 (16S, 23S)
            partial rRNAs                     :: 2, 1 (16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 190
            CDSs (without protein)            :: 190
            Pseudo Genes (ambiguous residues) :: 0 of 190
            Pseudo Genes (frameshifted)       :: 64 of 190
            Pseudo Genes (incomplete)         :: 160 of 190
            Pseudo Genes (internal stop)      :: 8 of 190
            Pseudo Genes (multiple problems)  :: 38 of 190
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 277079
            Orig. end                         :: 288372
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEU01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11293
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11293
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6293](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6293
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    721..735
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            1276..2133
                     /locus_tag="ASD26_RS11810"
                     /old_locus_tag="ASD26_27600"
     CDS             1276..2133
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049037.1"
                     /locus_tag="ASD26_RS11810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27600"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_056791835.1"
                     /transl_table=11
                     /translation="MTALMVLGAVLTGCGGRERSRTAALAPPASPGPSPGPGATVEARQ
                     GPPTMAPGPEGLTPVFERRAAGSRDGAPGADKTVALTFDADMTADQGPRASAGEHFDNP
                     GLIALLRRLKVPSTVFMTGRWAQEYPAQARSIGTDPLFEIANHSYSHYAFSSPCYGLPA
                     VAKADMRGDVERAFAAIRKTGARNVVPYFRFPGGCYDDASLKALAPTGVTAVQWDVVSG
                     DAFATDPEAVAEQVLSGVTPGSLVVMHCTRSAAPVTDEALERVVPELRERGYRFVKVSE
                     LMRG"
     gene            complement(2174..2353)
                     /locus_tag="ASD26_RS11815"
                     /old_locus_tag="ASD26_27605"
     CDS             complement(2174..2353)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049036.1"
                     /locus_tag="ASD26_RS11815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27605"
                     /product="hypothetical protein"
                     /protein_id="WP_056791832.1"
                     /transl_table=11
                     /translation="MDDSYCATPAPAPVPADAGPPYAACVLCRKPTEFPESTKGSTLCP
                     VCAWQEAGRTACSG"
     gene            complement(2382..3059)
                     /locus_tag="ASD26_RS11820"
                     /old_locus_tag="ASD26_27610"
     CDS             complement(2382..3059)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="ASD26_RS11820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27610"
                     /product="AIM24 family protein"
                     /protein_id="WP_056791831.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQQATAPGMTLQNSKSIKYAVNGEMHARQGSMIA
                     FRGDLQFERKGQGIGGMLKRAVTGEGLPLMAVRGQGEAWFAHEAANCFIVEMEQGDVLT
                     VNGRNVLCFDASLAYEIKTVKGAGMTGGGLFNSVFSGHGNLGLICDGQPIVIPVTAQQP
                     VYVDTDAVVGWSARLSTTLHRSQSFGSMVRGGSGEAVQLMLQGEGFVIVRPSELKPEKA
                     SAN"
     gene            3165..3917
                     /locus_tag="ASD26_RS11825"
                     /old_locus_tag="ASD26_27615"
     CDS             3165..3917
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523639.1"
                     /locus_tag="ASD26_RS11825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27615"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_056791829.1"
                     /transl_table=11
                     /translation="MSTPESPPGADREPVPADPADSPFRTEPTSRDEAPQFVLPLVVHI
                     EKTDPPARTDALRTAARAVLTMLSDERALGGGEWAQVMREWQDARIRKVVRRARGAEWR
                     KASALPGITVTGEHAEVRVFPPVPLDAWPRELAKLQVSGTDLDDPEPPAAPDRDAPVLW
                     MNPEVGMSAGKAMAQAGHGAQLAWWELSDTERKAWREAGFPLSVATPDPDLWRELTVSG
                     LPVVRDAGFTEIAPGSCTVVADHPALRR"
     gene            4126..4878
                     /locus_tag="ASD26_RS11830"
                     /old_locus_tag="ASD26_27620"
     CDS             4126..4878
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153331.1"
                     /locus_tag="ASD26_RS11830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27620"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_199862765.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATLGALAYPVWSYSDRSGTGEANLNASSVA
                     TQWGPLSATDRDFLVKVRLAGLWELPAGQQAIERAPSEAMKAAGDHLVVGHTDLDRRAR
                     DVAAKLGVELPNQPTEVQQGWLRELTAASGEEYERKFSNLLRAAHGKVFALIAEVRHTT
                     RNALIRQLASDANQTVLDHITMLERTGFVDFDGLAREAAGSSTASPSGPPMSSGGNVPQ
                     VPVPVTPSGDQSFTSRPVPPTMEPLPQP"
     gene            5001..6293
                     /locus_tag="ASD26_RS11835"
                     /old_locus_tag="ASD26_27625"
     CDS             5001..6293
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153332.1"
                     /locus_tag="ASD26_RS11835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27625"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_056791824.1"
                     /sec_met_domain="DUF692 (E-value: 1.9e-94, bitscore: 310.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGTGIGWRPEIEDAVEALPGIDWVEAVAENICTDHLPASLERL
                     RERGVTVVPHGVSLGLGGADRPDAGRLADLAARAVLLGTPLVTEHIAFVRAGGPLTASP
                     GLEAGHLLPVPRTWDALEVLCENVRIAQDALPVPLALENIAALVSWPGEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNRGEDPATALDELPVEAIAYVHVAGGVEKDGVWHDTHA
                     HPVTRPVLDVLAELRSRVDPPGVLLERDDDFPPAAELAGELTAIRATLATAAGTPAPAG
                     RRPARPSEPAGRTAGARLRVGTAQAALLSSLVAGAPAPEGFDHRRLGVQRRALAAKRAD
                     VVAKVAPELPEILGDGYRTAFLGYAGSRPMSAGYRRDALDFAEQLLVAGRPADDAARLR
                     LTHWWQDRAAPRPPRRTTRIARAARAALMGR"
     gene            6299..7333
                     /locus_tag="ASD26_RS11840"
                     /old_locus_tag="ASD26_27630"
     CDS             6299..7333
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153333.1"
                     /locus_tag="ASD26_RS11840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27630"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_056791822.1"
                     /transl_table=11
                     /translation="MNALALLMTLAVAVSSTLLIVAAQSAGRRGGADGYVHDRSEAAFL
                     NGGPARVVDTALTALHTDGRLVIGGPGIVVLQRAEARDPVERAVLQELAAAPSGALHTL
                     RQAVMVHPAVQEIGDGLAARGLMVAPGESRNRRRWALVQGVGCTVALPVSLVLTFVQYA
                     LHEGYADMPFPFIVKVLPALVAGSIVGFLTAASARARVTGAGRRAAAGYRAAHAHVADP
                     AHLVATAGLRALVDPELRGQLMAAARHPSARRPSPSHSPSADSYAGGVVLPVMWCAGAG
                     PGNGSCGSSDGGGGHGTGSSCSSGSSCGGGSGGGSSCGSSSGSSCGSSSGSSCGGGSSC
                     GSSS"
     misc_feature    complement(6343..6357)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            7471..8253
                     /locus_tag="ASD26_RS11845"
                     /old_locus_tag="ASD26_27635"
     CDS             7471..8253
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020207254.1"
                     /locus_tag="ASD26_RS11845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27635"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_056791819.1"
                     /transl_table=11
                     /translation="MLWVVLLLVAWGAAAVSCIRLCLVTAGAARWPAEAAREPVLHELN
                     LYETAFLAGGPHRVADLALLSMHLRRRLLLAHTGWATVVDPEGRDEVERTVIRAIGPEG
                     QSRIAPIRASAAAADAVRTLADRLVAAGLAVPHGTRTTLASAVRAVRGAAVLVVALAVA
                     AVLLPGQDPAYAGPVVAWFGLPLVLTLGCLAIARVEAHPCSPWASPSGQRWLDSLPAPE
                     HGADRDLLAAVAVRGVAAVEDPELRAALRSGRSALSSH"
     gene            complement(8519..9232)
                     /gene="hemQ"
                     /locus_tag="ASD26_RS11850"
                     /old_locus_tag="ASD26_27640"
     CDS             complement(8519..9232)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888541.1"
                     /locus_tag="ASD26_RS11850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27640"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_056791817.1"
                     /transl_table=11
                     /translation="MSAPEKLPNAGKKAKDLNEVIRYTLWSVFKLRDVLPADRAGYADE
                     VQELFDQLAAKDVVVRGTYDVSGLRADADLMIWWHAETSDALQEAYNLFRRTALGRALK
                     PVWSNMALHRPAEFNKSHVPAFLADEEPRGYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGFPDVRANTVPSFSLGDYEWVLAFEADELYRIVDLMRHLRASEARLHVREEVPFY
                     TGRRKSVADLVSGLA"
     gene            complement(9237..10748)
                     /gene="hemG"
                     /locus_tag="ASD26_RS11855"
                     /old_locus_tag="ASD26_27645"
     CDS             complement(9237..10748)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579252.1"
                     /locus_tag="ASD26_RS11855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD26_27645"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_056791815.1"
                     /sec_met_domain="DAO (E-value: 1.5e-13, bitscore: 45.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSPLQRDTTRTGHVVVIGGGIAGLAAAHRLLSTGLRVTVLEATE
                     RLGGKLMTGEIAGTRVDLGAESMLARRPEAVELATAVGLGGRLQPPATATASVWTRDAL
                     RPMPKGHVMGVPGDPAALSGVLSPEGLARIAQERDLTPTAVGDDVAVGAYVADRLGREV
                     VDRLVEPLLGGVYAGDAYRISMRAAVPQLFEAVKEGGSLLDCVRRVQERAAARQQTGPV
                     FQGIDGGIGTLPDAVADAVRAGGAEILLATPVLGLTRTARGWDVRTDTRVIDADGIVLA
                     TPAWSASTLLAAESPAASVELAAVEYASMALVTLAFRRSDIAGTQALHGRSGFLVPPVD
                     GRTIKASTFSSHKWQWVADAAPDLFVLRTSVGRYGEEEHLHREDSELVDVSLSDLAAAT
                     GLAARPVDTEVTRWIGGLPQYPVGHLTRVARIRDEVARLPGLRVCGAVYDGVGIPACIA
                     SARRAADEITRDLTGVDGGGNARKIAEEIIATPTRVQGTRSEAGQ"
     misc_feature    10798..10813
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
ORIGIN
        1 ccatctggtg cgcaaccacg agaaccgggt caccggcagg atcggcgtcc cgacggtcga
       61 gggcctcacg tacgacccga tgggcaaggg cggttgtacg gccctggagc tcgacagccg
      121 gggcaacgtg ctcggcgaga gggtcgcgat cgccggtacg gcggtcaact gcgcgggcgg
      181 gcccaccccg tggaacacct ggctgacctg cgaggagacc gaggacaagg ccggtaccaa
      241 cggctacacg aaggaccacg gcttcatctt cgaggtggac ggcgccgatc cgcgccgcac
      301 cggggcagtc cccctgaccg cgatgggccg tttccagcac gaggcgatcg cggtcgaccc
      361 gaagaacggg gtcgtgtacg agacggagga cgcgttcgac cggccgttcg ggctcttcta
      421 ccgtttcctg cccgagaagc cgctcggcgg cacgggctcg ctgcgggccg ggggcgcgct
      481 cgaagccatg agggtccccg gactgcccga cctgtccgtg gtccaggaga ccggtgcgag
      541 cttcgaccgg gtcgagtggg tcccggtgcc cgatccgcag gccaccgaga caccgatccg
      601 gctgcaggac ttcgggccca ggggcgtcac gcacgcccag aagctggagg gctgctactg
      661 gggcggctcg tccgtctact tcgtctccag cttcgctcac agctcggagg ggtcggccgc
      721 cgaccacttc ggccaggtct ggcggtacga gcccaagcgg cgccggctca cgctggtggt
      781 cgtcttcggc ccggacacgg acatccagct gcccggcgag tccccggaca acatctgcct
      841 cgccgccgac ggcgggctga tggtgtgcga ggacggcggc ggcgcacagc acgtgctcgg
      901 ggtgacgcgg cgcggagagg tctatccgat ggcgcggggg cggcagaaca ccgggacggc
      961 cgatgacccg gagtggggcg aattcgcggg ggtcacgttc tcgccggacg gcggaacgat
     1021 gttcgtgaac tgctacacgc cgggcacgac gttcgccgtg acgggcccct ggcgctgagc
     1081 ggccgggtaa cgggccgcgg ggccgggcag cggtggctgc ccggccccgc ggtggttccc
     1141 ggcaccgtga cgccgcgggc gggagctcgc ggcgaggggc cgccggtggt gcgggacgtg
     1201 gaggcccgga gtgccgcgac cggattctga tgcctcatca gctaacgtct cccggtgatc
     1261 aaatccgttc gtacgatgac agcactgatg gtgctgggtg cggtcctcac cggctgcggc
     1321 ggccgggagc gctcgcgcac ggcggccctc gcgcccccgg cgagccccgg ccccagcccc
     1381 ggccccggcg cgacggtcga ggcgcgacag gggccgccca ccatggctcc cgggccggag
     1441 ggcctgaccc cggtcttcga gcgccgggcc gccggctccc gcgacggcgc ccccggggcc
     1501 gacaagaccg tggcgctcac cttcgacgcg gacatgacgg cggatcaggg gccacgtgcc
     1561 tcggcgggcg aacacttcga caacccgggc ctcatcgcgc tgctgcgccg gctgaaggtg
     1621 ccctcgacgg tcttcatgac cgggcggtgg gcccaggagt accccgccca ggcccgctcg
     1681 atcggcaccg atccgctgtt cgagatcgcc aaccactcgt acagccacta cgccttctcc
     1741 tcgccctgct acgggctgcc ggccgtcgcg aaggccgata tgcgcggcga tgtggagcgg
     1801 gccttcgccg cgatccggaa gacgggggca cgcaacgtcg tgccgtactt ccgcttcccc
     1861 ggcggctgct acgacgacgc gtcgctgaag gccctggcgc cgaccggggt cacggcggtg
     1921 cagtgggacg tggtcagcgg ggacgcgttc gccacggacc cggaggcggt ggccgagcag
     1981 gtgctgagcg gggtgacgcc cggatccctc gtggtcatgc actgcacccg cagcgccgca
     2041 cccgtcaccg acgaggcgct ggagcgggtg gtcccggagc tgcgcgagcg gggctaccgc
     2101 ttcgtcaagg tctccgagct gatgcggggc tgagcacaca cggcggaccc gccgcgcacg
     2161 ccgcccgccc gcgtcacccg gagcaggccg tgcggcccgc ctcctgccag gcgcagaccg
     2221 ggcagagggt gctgcccttc gtcgactccg ggaactcggt cggcttccgg cacagcacgc
     2281 atgcggcgta cggcgggccc gcgtccgcgg gtacgggggc cggagcgggc gtcgcgcagt
     2341 acgagtcgtc catgcgtccg agcgtactca cccgcgcggg ctcagttggc cgacgccttc
     2401 tccggcttga gctcgctggg gcggacgatc acgaatccct cgccctgcag catcagctgg
     2461 acggcctcgc cggagccgcc gcgcaccatc gagccgaagc tctgcgaacg gtgcagcgtg
     2521 gtggagagcc gggcgctcca gccgacgacc gcgtccgtgt cgacgtacac gggctgctgg
     2581 gccgtgacgg ggatcacgat gggctggccg tcgcatatca ggccgaggtt gccgtggccg
     2641 ctgaagacac tgttgaagag accgccgccg gtcattccgg cacccttcac cgtcttgatc
     2701 tcgtacgcga ggctcgcgtc gaaacagagg acgttgcgcc cgttgacggt caggacgtcg
     2761 ccctgttcca tctccacgat gaagcagttg gccgcctcgt gggcgaacca cgcctccccc
     2821 tggccgcgaa ccgccatgag cggcaggccc tcgccggtga ccgcgcgctt gagcatgccg
     2881 ccgatgccct ggcccttgcg ttcgaactgc agatcgccgc ggaacgcgat catcgacccc
     2941 tgacgcgcgt gcatctcacc gttgacggcg tacttgatgg acttggagtt ctgcagggtc
     3001 ataccggggg cggtggcctg ctgggccatg tgctcgctgg aaaagaggtc gctcttcatg
     3061 ccccgcatcc tcacccggac cccttcgttc cagcaaggac cggtttccgc gggcctggca
     3121 gactggagcc cgtgagcagc gaagaccgtc ccgagccctt taccgtgtcc accccggagt
     3181 cccctcccgg ggccgaccgg gagcccgttc cggcggatcc cgcggacagc ccgttccgta
     3241 cggagccgac ctcccgcgac gaggcgccgc agttcgtgct gccgctggtg gtgcacatcg
     3301 agaagacgga cccgccggcg cgcaccgacg cgctgcggac cgcggcgcgc gcggtgctca
     3361 cgatgctctc cgacgagcgt gcgctcggcg ggggcgagtg ggcgcaggtc atgcgggagt
     3421 ggcaggacgc ccggatccgc aaggtggtgc ggcgtgcccg gggtgcggag tggcgcaagg
     3481 cgtccgcgct gcccgggatc acggtcacgg gcgagcacgc ggaggtacgg gtgttcccgc
     3541 cggtgcccct ggacgcctgg cccagggaac tggccaagct ccaggtgtcg ggcacggacc
     3601 tggacgaccc cgagcccccg gccgcgcccg atcgggacgc tccggtgctg tggatgaatc
     3661 ccgaggtcgg catgtcggcg ggcaaggcca tggcccaggc cgggcacggc gcacagctcg
     3721 cctggtggga gctgtcggac acggagcgca aggcctggcg ggaggccgga ttcccgctct
     3781 ccgtggccac cccggacccg gacctctggc gggagctcac cgtgagcggg ctgccggtgg
     3841 tgcgggacgc cggcttcacc gagatcgcgc cgggttcctg cacggtggtc gcggaccatc
     3901 cggcgctgcg ccgctgaacg cggggccccg gggcgggcgt ggggccgcgc gtccgagccg
     3961 gtgcggcctc ccggcggaag atccgccggt gctgttgaac atccctgcgc cgatgtacgt
     4021 atctcccggt actgccgcac cggcattacc gccaagtagg ttgaacgccg agtcagttgg
     4081 cggttgattc agagctgtca cacatcggcc cgggagacat acgtgttgcg acgcatcaac
     4141 ggaacggccc tcatcatcgc ggcactggtc gccacgctcg gcgcactcgc ctatcccgtg
     4201 tggtcctact cggaccgctc gggcaccgga gaggccaatc tgaacgcctc cagcgtcgcc
     4261 acccagtggg gcccgctctc ggcgacggac cgcgacttcc tggtcaaggt gcgcctcgcg
     4321 gggctgtggg aactgcccgc ggggcagcag gcgatcgagc gggcaccgag cgaggcgatg
     4381 aaggcggcgg gcgaccacct ggtggtcggc cacaccgacc tggaccggcg ggccagggac
     4441 gtggcagcca agctcggggt ggagctgccg aaccagccga cggaggtgca gcagggctgg
     4501 ttgcgcgagc tcacggcggc gagcggcgag gagtacgagc gcaagttctc caatctgctg
     4561 cgggccgcgc acggcaaggt cttcgcactg atcgccgagg tcaggcacac cacgcgcaac
     4621 gcgctcatcc ggcagctggc ctcggatgcc aaccagaccg tcctggacca catcacgatg
     4681 ctggagcgca ccggcttcgt cgacttcgac ggcctggccc gtgaggcggc cggcagctcg
     4741 acggccagcc cctcgggccc gcccatgtcc tcgggcggca acgtcccgca ggtcccggtg
     4801 ccggtgactc cgagcggcga ccagtcgttc acctcacgcc ccgtgccgcc cacgatggag
     4861 cccttgccac agccctgatc acggcatcgt gacgccggga acctcagatc cagctctgaa
     4921 cgtcccctgt ttcggattca ccaccgcccg gcggggccat cacccccgta cgaagcggcg
     4981 gagccgatga gggggacggg atgaagctgg gaacgggaat cggctggcgg ccggagatcg
     5041 aggacgccgt cgaggcgctg cccgggatcg actgggtcga ggcggtcgcg gagaacatct
     5101 gcaccgacca cctccccgcg tcgctcgaac ggctcaggga gcgcggcgtc accgtggtcc
     5161 cgcacggcgt ctcgctgggc ctcggcgggg ccgaccgccc cgacgcgggc cgcctcgccg
     5221 acctggcggc gcgggccgtg ctgctgggga caccgctggt gacggagcac atcgcgttcg
     5281 tacgggccgg ggggccgctc accgcgtcgc cggggctgga ggcgggccac ctgctgcccg
     5341 tgccccggac ctgggacgcg ctggaggtgc tctgcgagaa cgtccggatc gcgcaggacg
     5401 cgctgcccgt accgctggcg ctggagaaca tcgccgcgct ggtctcctgg cccggcgagg
     5461 agctgaccga ggggcagttc ctcgcggaac tggtcgagcg gaccggggtc cggctgctga
     5521 tcgacgtggc caatctgcac accaaccacg tgaaccgggg cgaggacccc gcgacggccc
     5581 tcgacgaact gccggtcgag gccatcgcgt acgtgcatgt ggcgggcggc gtcgagaagg
     5641 acggggtctg gcacgacacg cacgcccacc ccgtgacccg ccccgtcctg gacgtgctgg
     5701 ccgagctccg ctcccgggtc gaccccccgg gcgtcctgct ggagcgcgac gacgacttcc
     5761 cgccggccgc cgagctggcc ggcgaactga ccgcgatccg cgccaccctg gccacagcgg
     5821 ccggcacccc ggcgcccgcg gggcggcggc cggcccggcc gtcggagccg gccggccgga
     5881 ccgccggtgc acgtctgcgg gtcggcacgg cccaggccgc gctgctctcc tcactggtcg
     5941 ccggcgcgcc cgccccggag ggcttcgacc accggcggct cggggtgcag cgccgcgccc
     6001 tggccgcgaa acgggccgac gtcgtcgcca aggtggcccc ggagctgccg gagatcctcg
     6061 gcgacggcta ccgcacggcg ttcctcggct acgccgggtc ccggcccatg tccgccgggt
     6121 accgccgtga cgccctggac ttcgccgaac agctcctcgt cgccggccgt ccggccgacg
     6181 acgcggcccg gctgaggctg acccactggt ggcaggaccg ggcggctccg cgtccgccgc
     6241 gccggaccac caggatcgcc cgggcggccc gtgccgccct gatgggaagg tgaccccgat
     6301 gaacgccctc gcccttctga tgaccctcgc cgtggcggtc tcctcgacgc tcctgatcgt
     6361 ggcggcccag agcgccggcc gtcgcggcgg tgccgacggg tacgtgcacg accgttccga
     6421 ggcggcgttc ctcaacggcg gccctgcccg ggtcgtggac accgcgctca ccgccctgca
     6481 cacggacggg cgcctggtca tcggtggccc cggcatcgtg gtcctgcagc gggccgaggc
     6541 ccgggacccg gtggagcgtg ccgtgctcca ggagctggcc gccgccccga gcggggccct
     6601 gcacacgctc cggcaggccg tgatggtgca cccggcggtg caggagatcg gtgacggtct
     6661 cgcggcccgc ggcctgatgg tcgcaccggg cgagagccgg aaccgccgcc ggtgggcgct
     6721 cgtccagggc gtggggtgca cggtggccct cccggtcagc ctggtgctga ccttcgtcca
     6781 gtacgccctg cacgagggct acgccgacat gccgttcccg ttcatcgtga aggtacttcc
     6841 ggcactcgtg gccgggagca tcgtgggctt cctcaccgcc gcgtcggcca gggcccgggt
     6901 caccggggcc gggcgccggg ccgccgccgg ataccgggcc gcccacgccc atgtggcgga
     6961 cccggcccac ctggtggcca ccgcggggct gcgtgcactc gtcgaccccg agctccgggg
     7021 gcagttgatg gcagccgcac gtcatccctc cgcccggcgc ccctcgccgt cgcactcccc
     7081 gtcggccgac tcgtacgccg gcggcgtggt cctgccggtg atgtggtgcg ccggtgcggg
     7141 ccccgggaac ggcagttgcg ggagttccga cggcggcggc ggccacggaa cgggctcctc
     7201 ctgcagttcc ggatcgagct gcggcggggg atcgggcggc gggtcgagct gcgggagcag
     7261 cagcgggtcg agctgcggca gtagcagcgg gtcgagctgc gggggtggtt ccagctgcgg
     7321 cagcagctcc tgaacgtacg gatccgggtc gcgggcggcg acagccgccg agcatgcgga
     7381 ttcagccacc gatgaccgcg cgtgaccaca cttcgtccat atcgtgaaca gacagtggcg
     7441 ccccccactc atctcgcata caaatccgcc atgctctggg tcgtgcttct tctggtcgcg
     7501 tggggcgccg cggccgtctc ctgcatccgt ctctgcctcg tcaccgcggg cgcggcccgg
     7561 tggccggccg aggccgcccg tgaacccgtg ctccacgaac tcaacctgta cgagacggcc
     7621 ttcctggccg gcggcccgca ccgggtcgcc gacctggcgc tgctctccat gcacctgcgc
     7681 cgccggctgc tgctcgccca cacgggctgg gcgacggtcg tcgacccgga gggccgggac
     7741 gaggtcgagc gcaccgtgat ccgagcgatc ggcccggagg ggcagtcccg catagcgccg
     7801 atccgggcgt ccgcggctgc ggcggacgcc gtgcgcaccc tcgccgaccg gctcgtggcc
     7861 gcgggcctcg ccgtaccgca cggcacccgg acgaccctgg cgtcggccgt gcgggcggta
     7921 cggggcgcgg ccgtgctcgt ggtggcgctg gccgtcgccg ccgtgctgct gccgggtcag
     7981 gaccccgcgt acgcggggcc ggtggtggcc tggttcgggc tgccgctggt actgacgctg
     8041 ggatgcctgg ccatcgcgcg ggtggaggcc catccctgca gcccctgggc ctcgccgtcc
     8101 gggcagcggt ggctggactc gctcccggcg ccggaacacg gcgcggaccg cgacctgctg
     8161 gcggcggtgg ccgtacgggg cgtggcggcc gtggaggacc cggaactgcg ggcggccctg
     8221 cgcagcggtc gctcggcact ttcgagccat tgacgggccg ggacggcgaa agggccgccc
     8281 cctcgacggg agcggccccg atgcggtgcc tgttcggccc ggggcacatc ggccgcacgc
     8341 ggcgaggagc gagggcctgc ggggaggaat ggctgactcc cccgcagacc accgcagttc
     8401 gccggcgctg ggccgatgtg cccggagccg gacccggtgt cgttggaacg acgggcggcg
     8461 tcacacgcgc cgtagcccgc caactgatct tccgggtcgg ggtgaccgga aacgctggtt
     8521 atgcgagacc ggacaccaag tctgcgacgg acttcctgcg ccccgtgtag aacgggacct
     8581 cctcacggac gtgcagccgt gcctcggagg cccgcagatg acgcatgagg tccacgatgc
     8641 ggtacagctc gtcggcctcg aacgccagga cccactcgta gtcgccgagc gagaaggagg
     8701 gcacggtgtt ggcgcgcacg tcggggaagc cgcgggccat cttgccgtgg tccgcgagca
     8761 tacggcggcg gtcctcgtcc gggagcaggt accagtcgta gctgcgcacg aaggggtaca
     8821 cgctgacgta gccgcgcggc tcctcgtcgg ccaggaaggc cggcacgtgc gacttgttga
     8881 actcggcggg gcggtgcagc gccatgttcg accagaccgg cttcagagcg cggcccagag
     8941 cggtgcgccg gaagaggttg tacgcctcct ggagggcgtc ggaggtctcg gcgtgccacc
     9001 agatcatcag atcggcgtcg gcccgcagac cggacacgtc gtaggtgccg cggacgacga
     9061 cgtccttggc cgcgagctgg tcgaagagct cctggacctc gtcggcgtaa ccggcgcggt
     9121 ccgcgggaag cacatctcgc agcttgaaca cggaccacag ggtgtagcga atgacctcgt
     9181 tgaggtcctt ggccttcttg cctgcgttcg gaagcttctc tggcgcactc atacggctat
     9241 tgtcccgcct cgctccgggt gccctgaacc cgggtcggcg tggcgatgat ctcctccgcg
     9301 atcttccgcg cgttcccgcc cccgtccacc cccgtcaggt cccgggtgat ctcgtccgcg
     9361 gcccgtcggg cgctggcgat gcaggcgggg atgccgaccc cgtcgtacac cgctccgcag
     9421 acccggagcc ccggcagcct ggcgacctcg tcacggatcc gggcgacccg cgtcagatgc
     9481 cccacggggt actgcggcag gccgccgatc caccgggtca cctcggtgtc gaccggccgt
     9541 gccgccagcc cggtggctgc ggccaggtcg ctcagcgaga cgtccacgag ctcggagtcc
     9601 tcgcggtgca ggtgctcctc ctcgccgtac cggccgacgg aggtgcgcag cacgaagagg
     9661 tccggggcgg cgtccgcgac ccactgccac ttgtggctgg agaaggtcga cgccttgatc
     9721 gtgcgtccgt cgacgggcgg gacgaggaaa cccgaacggc catgcagcgc ctgcgtccca
     9781 gcgatgtcgg aacgccggaa ggccagggtg accagggcca tcgaggcgta ctccacggcg
     9841 gccagttcca cggaggcggc cgggctctcg gcggcgagca gcgtggacgc cgaccaggcc
     9901 ggggtggcca ggacgatgcc gtcggcgtcg atcacccggg tgtcggtgcg tacgtcccag
     9961 ccccgcgcgg tccgggtcag cccgagcacg ggggtggcca ggaggatctc cgctcccccg
    10021 gcgcgcacgg cgtcggccac ggcgtccggc agggtgccga tgccgccgtc gatgccctgg
    10081 aacaccggtc cggtctgctg ccgggcggcg gcccgctcct ggacgcgccg gacgcagtcg
    10141 aggagcgagc cgccctcctt cacggcctcg aagagctgcg gtaccgctgc gcgcatcgag
    10201 atccggtagg cgtcacccgc gtacaccccg ccgagcagcg gctccacgag ccggtcgacg
    10261 acctcgcggc cgagccggtc ggcgacgtac gcgccgaccg cgacgtcgtc gccgacggcg
    10321 gtcggggtga ggtcgcgttc ctgggcgatc cgggccagcc cttccgggga gagcacaccg
    10381 ctgagcgccg ccgggtcgcc gggcacaccc atcacgtgcc ccttgggcat ggggcgcagg
    10441 gcgtccctgg tccacaccga cgcggtggcg gtggcgggcg gctgcagccg cccgccgagg
    10501 cccaccgcgg tggccagctc caccgcctcg gggcggcggg cgagcatcga ctcggcaccg
    10561 aggtcgacgc gggttcccgc gatctcgccg gtcatcagct tgccgccgag ccgctcggtc
    10621 gcctcgagga cggtgacccg gagaccggtg gagagcagcc ggtgggcggc ggcgagtccg
    10681 gcgatgccac cgccgatgac gacgacgtgg cccgtacgcg tggtgtcgcg ctgaagagga
    10741 gactgcatgg gtccactctc tcaaaccccc ttccgagtcc cgaacgtgac cgcttcgaaa
    10801 cccctggggc gaaacccgca caggggcccc gtgcgtcgaa ccggcatcaa gagcaacggc
    10861 cctgggggga ctcgctatgc agatcgaccg ccacaccgac cgtcatccac ccgtaggccc
    10921 gcccctgcgc cccgcgcatc gttctcgcgc ggtcctggcc gccgggctgc tcgtcgtcct
    10981 gctgggcacc ggcgcctgcg gtgcctcgga ctccttcgac agctcgtcga gcgagaaggg
    11041 tgtcgcggcc tccgaccgac ggggcccggc atccggcgcg gagggcggca gcgcggagtc
    11101 ggacagcaag ccggccgccg gcaagtccgc ggccggctcc ccggccgcgc cgaagccggg
    11161 ggccgccgcc gcggtccacg tcatccgcac cgcgaccctg gacgtcgagg tcaggagcgt
    11221 gccgaaggcg gtcgccgccg cccgtggcgc tgcggagagg gccggcggcc tcgtctcgga
    11281 ggagaccacg gaa
//
