LOCUS       NZ_LMEI01000006        10816 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces sp. Root431 contig_2, whole genome shotgun sequence.
ACCESSION   NZ_LMEI01000006
VERSION     NZ_LMEI01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root431
  ORGANISM  Streptomyces sp. Root431
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 680762)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 680762)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140605
            Assembly Name                     :: Root431
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426585.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 02:21:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,904
            CDSs (total)                      :: 5,829
            Genes (coding)                    :: 5,744
            CDSs (with protein)               :: 5,744
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 22 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 1 of 85
            Pseudo Genes (multiple problems)  :: 10 of 85
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:56:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 498941
            Orig. end                         :: 509757
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEI01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5816](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5816
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(932..947)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    1010..1025
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.98"
                     /tool="antismash"
     gene            complement(1433..3703)
                     /locus_tag="ASC82_RS06645"
                     /old_locus_tag="ASC82_06035"
     CDS             complement(1433..3703)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381958.1"
                     /locus_tag="ASC82_RS06645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06035"
                     /product="FdhF/YdeP family oxidoreductase"
                     /protein_id="WP_056643408.1"
                     /transl_table=11
                     /translation="MGPTPEGEPEFHPYHHPAAGWGAAKSVTRFLLAEGALVDGPRAIM
                     KMNHENTGFDCPGCAWPDDTKGLHLDICENGIKHVTWEMTRKRVGREFFAAHSVTELAG
                     WSDYDLENQGRLTEPMVYDPDTDHYVPISWKDAFDVVGRTLRELDSPHRAAFYTSGRLG
                     NEATFLYQLMARELGTNNLPDCSNMCHEASGRALQASLGTGKGTVDLKDWESADALFIL
                     GVNAASNAPRMLTALAEAHHRGAQIVHVNPLVEAAATRTIVPHDFLDMALFKTTKTSTL
                     NLQPRIGGDMALLRGMAKAILEQSETDPKALDREFIERHTAGFDEYRAVCEATSWEQLE
                     RQSGLSRADILAAARVYGEADRSIVSWCLGVTQHEHGVDTVREIVNVLLLRGNLGREGA
                     GPSPVRGHSNVQGNRTCGIDHRPSEAFLDRLSEVCGIEPPREHGLDTVRTITAMHDGDV
                     TVFVGMGGNFALAAPDTPYTYAALANCDLTVQVSTKLNRSHVVHGRRALILPCLGRTEK
                     DHQRKGIQSTSVEDSMSMVHLSVGMKRPASPHLLSEPAIVAGMARAALPGSATPWEWYI
                     EDYDRIRDTMARALDGFEDFNRRVRLPLGFRIKQPARELVFLTPSGRAEFSSAALPDVV
                     PAPGTLALGTMRSHDQWNTTIYSDNDRYRGVKNLRTLVFMNRADMRERGIPDLGPVDIT
                     STAKDGSRRFLRGYLAVPYDIPRGCAAGYMPEMNVLCALSDYSTQSDQPIMKHLKVTIG
                     PAA"
     gene            4009..5004
                     /locus_tag="ASC82_RS06650"
                     /old_locus_tag="ASC82_06040"
     CDS             4009..5004
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018834462.1"
                     /locus_tag="ASC82_RS06650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06040"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_056642895.1"
                     /transl_table=11
                     /translation="MVVAQSVLTPTSPTAVFVVATVSPGGETAVREVLQDLAGLTRSVG
                     FRSPESALRCVVGVGSDAWDRLVGGPRPRDLHPFPPLRGPRHRAPATPGDLLFHLRARR
                     MDLCFELARLILDRLGGAVTVVDEVHGFTYFDERDLLGFVDGSENPSGEAAADAVRIGD
                     EDPDFRGGSYVVVQKYLHDMTAWESLTVEEQERVIGRTKQANVELPDGVKPADSHVALN
                     TVVDDDGAEQQILRQNMPFGQVGSGEMGTYFIGYARTPAVTERMLRNMFLGDPPGNTDR
                     ILDFSRAVTGCLFFVPSADLLDDLPAAPSAAAASPGDSLGIGSLKGAPAS"
     gene            5001..5816
                     /locus_tag="ASC82_RS06655"
                     /old_locus_tag="ASC82_06045"
     CDS             5001..5816
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240918.1"
                     /locus_tag="ASC82_RS06655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06045"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_056642898.1"
                     /sec_met_domain="Linocin_M18 (E-value: 5.8e-89, bitscore:
                     292.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPDVTNNLHRELAPITPAAWAEIEEEARRTFRRHVAGRRVVDV
                     PDPAGPGLAAVGVGHLTDIHPPAPGVSARLREARPIVELRVPFSVSRAAVDDVERGSKD
                     SDWQPVKDAARTMAYVEDRTIFDGYGAAGVDGLRSRSSHPVLRLPTEAREYPDAVSRAL
                     TQLRLVGVDGPYALLLGADEYRAVSETSDHGYPIAAHLGRMLDGSPIWAPALSGGFVVS
                     TRGGDFELLLGQDVAIGYTGHDATTIDLYFHETLTFLTYTDEAVVVLEA"
     gene            5819..6454
                     /locus_tag="ASC82_RS06660"
                     /old_locus_tag="ASC82_06050"
     CDS             5819..6454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240917.1"
                     /locus_tag="ASC82_RS06660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06050"
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_242427579.1"
                     /transl_table=11
                     /translation="MHRWLVDAVPRLVGATAVGAAAGVLVGLLSDAPLGALAGIAAAEA
                     LFVVTGWLVLWPMDAATTHRNVRREEFRPVVEELVVVGTAVCGLVGIIVMLLVGQSGLG
                     HAAAATALGGVFTAWAALHLMYATRYAYDYYAVEPGGGIDFNTDDPPRYSDFLYFSFNL
                     GMTYQVSDTNVSQSSLRAIVLRHCLLSYVFGASILATTINLVTGIVTG"
     gene            complement(6582..7073)
                     /locus_tag="ASC82_RS06665"
                     /old_locus_tag="ASC82_06055"
     CDS             complement(6582..7073)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037713.1"
                     /locus_tag="ASC82_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06055"
                     /product="GreA/GreB family elongation factor"
                     /protein_id="WP_056642901.1"
                     /transl_table=11
                     /translation="MTGGPEPLSDVAREAFTRELADLRTEREAVAVTLRDGGGDQVGDR
                     ADQADELQRVTELQHLDARIAEIEGRLREGAVAGPPSTDTVGVGSTVTLRLADAMEATV
                     QIGEVAEVLDATMVTADSPLGSALLGHRVGDTVTYDTPGGPATAVVLSLGDGDGKGAPS
                     "
     gene            7406..8620
                     /locus_tag="ASC82_RS06670"
                     /old_locus_tag="ASC82_06060"
     CDS             7406..8620
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128214.1"
                     /locus_tag="ASC82_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06060"
                     /product="S8 family peptidase"
                     /protein_id="WP_056642904.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.9e-37, bitscore:
                     123.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALPQRTKARLALTVSAATAAALLGTFAAVPAQAAPAEGVVLGAG
                     SADAVPGSYIVTLKQGAGFKAGSAKGRTLIAGYGGTVRKTFGSALNGYTATLGATEARR
                     LAADPAVASVEQNRVFRADATQTNAPWGLDRIDQANLPLDGSYTYPDSAGGGVTAYVID
                     TGVRISHAQLGGRAVNGYDAVDGDTVAQDGNGHGTHVATTIAGSTYGVAKAARIVAVRV
                     LDNAGSGTTAGVIAGIDWVTSHHTAGAPAVANLSLGGGASTALDNAVKNSIADGVTYAV
                     AAGNSGVNASSSSPARVAAAITVGATSNTDAKASWSNYGSVLDLFAPGVSITAGWNTSD
                     TATNTISGTSMATPHVAGAAAVYLAGHPSATPAQVATALVNGATPNKVTSPGSGSPNRL
                     LRIVP"
     misc_feature    8703..8718
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(8711..8726)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     gene            8742..10430
                     /locus_tag="ASC82_RS06675"
                     /old_locus_tag="ASC82_06065"
     CDS             8742..10430
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038128.1"
                     /locus_tag="ASC82_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_06065"
                     /product="glycosyl hydrolase family 8"
                     /protein_id="WP_056642907.1"
                     /transl_table=11
                     /translation="MRRRSVSLLGLAGLLVLPLTSVPQALAQPQAQPRAQDQAAAADSL
                     VSVGKPVTASSVEASGFEPGLAADGSATTRWASAEGVDPQWVRIDLGTNHTVSRVKLNW
                     EAAYGKAYKIQTSADGSTWTDVYATTTGDGGVDDLAVTGSGRYLRMHGTARGTPYGYSL
                     WEFEVYGSPSGGGVPGGPAVPFGSHLKPYAAGTLKPSGAQATIDQKVVDYYNKWKAAFV
                     RQNCGNGWYQIISPDADHPYVAEAQGYGMVVTATMAGADPDAKKIFDGLVKWKIDHPSA
                     INPNLLAAEQDVACKSVNGGDGATDGDMDVAYGLLLADKQWGSAGTYNYKDLALKHIAA
                     IKKDELNPTTKLLKLGDWSSSGDQYYYISRTSDWMVDHFRAFRTASGDTTWDAVRTAHQ
                     TQITRLQSTYASGTGLLPDFVVDTNTTPKPAPGQVLEDPNDGAYWWNACRTPWRIADDA
                     VTSGDAGSLAAARKLNSWIKTKTGGDPNKIAIGYKLNGTQISAGSEAAFFAPFAVAAMT
                     DPGSQAWLDALWNKMLVTPVDTSSYFSASIQLQVMITASGNHWVP"
ORIGIN
        1 tgggccgatc cgacggccgg gggagcgggc gccgccgtgg tggtcgttgc gacggccgtc
       61 gtggccgggc tcgccaagtt cgcctgcgac gcggcacgcc tcaccggcct cggcgcggtc
      121 ctgttgcttt tctccttcgc cgtggcggcc aacggctcct cgacgccggc cgacgtcctg
      181 ccccacaccg ccctggccgc gacgggcgcg gccgtggcct gggtgctcgc cgtcgccggc
      241 cggttcgtcc atccggaccg gccgcagcgc ctcgccgtgg ccgcggcgct ccgcgagctc
      301 gcggacctcc tcgacgtcca ggaggccacc ggcgcggcgt acggcagggg gcttccccgg
      361 catcgcgcga ccgccgccgt cctccaggcg taccggacgc tggggctcgt gccaccgacc
      421 gccgccggag ccgcacgcgg agaccgcggc ggcacctgcg tgcgtctcgc cgacctcgcc
      481 tggtcgctgc tcatggaccg cgcccgccgt ccgtccgacg accccaccgg cctggcccgc
      541 gtcctccgcg cccaggtccg cctgctcgtg agccgtcggc tgcgggcccc gcggctcctg
      601 cccgaactcg cgctcctgtc cgccctggcg aaggacgaca ccgcgcccgg cccggcctcg
      661 cccgacccga ccacgcgccg cgccgccgaa ctccgggccg cggaactcct gacgggccgc
      721 ccgaactccg cgacgcacgc cgcggtcctg ctcgtccccg ccctgcgcat ggtcctcggc
      781 accggactcg cgggcggcgc cgccctgctg ctcggcctcg gccacggcta ctgggcggcc
      841 gtgtccgccg ccgccgtcct gcactcgatc aacgtccgta cggcgaccca gcgcgccgtc
      901 cagcgcaccc tcggcacggt cgtcggtctg gcgctcgccc tcggcgtgct cgccgcgggc
      961 cccgagcccg tggtgctggt cctggtgatc gtgctcctgg agttcctgct cgaatacgtg
     1021 gtcgcccgga actacggcct cggtgtcgtc ttcctgaccc cgctcgccct gctgctcacg
     1081 gacctggccg ccgcctcgcc ggccggggcg ctcgtccagg accgggcgct gggcagcgtc
     1141 ctcgggatgg gcatcgccct gctctgcgcg ctgctcgtcg tccacgaccg ggcggcggtc
     1201 cgggcgcagc gcgcgctcgc cgcgtgcacg gcggcggccg acgcggcggc acgcgccctg
     1261 gccgacgggg cggagggcgc gtacccgctc gtgcagacgc ggctcgcggc ggccgtcgtg
     1321 gagctgcgcg aggccgacga cgccgcggcg ggcgagctct ggcccgccga gatggacccc
     1381 accgaactgg ccgccgccga gcagcgcgcg taccggctcc tggagcggct cgtcaggccg
     1441 ccgggccgat cgtgaccttg aggtgcttca tgatcggctg gtcgctctgg gtgctgtagt
     1501 cgctcagcgc gcacagcacg ttcatctccg gcatgtagcc ggcggcgcaa ccccggggga
     1561 tgtcgtacgg gaccgcgagg tagccgcgca ggaaccgccg gctgccgtcc ttcgcggtgc
     1621 tcgtgatgtc gacgggcccg aggtcgggga tgccgcgctc gcgcatgtcg gcccggttca
     1681 tgaagacgag cgtgcggagg ttcttgacgc cccggtagcg gtcgttgtcg gagtagatcg
     1741 tggtgttcca ctggtcgtgg gaccgcatcg tgccgagcgc cagggtgccg ggggcgggga
     1801 cgacgtccgg cagggccgcc gaggagaact cggcgcgccc ggacggcgtg aggaagacca
     1861 gttcccgggc gggctgcttg atgcggaagc cgagcggcag ccggacgcgc cggttgaagt
     1921 cctcgaagcc gtcgagggcc cgggccatgg tgtcgcggat gcggtcgtag tcctcgatgt
     1981 accactccca cggcgtcgcg ctgccgggca gcgccgcgcg cgccatgccc gcgacgatgg
     2041 ccggctcgga gagcaggtgc ggcgacgcgg ggcgcttcat gccgacggac aggtggacca
     2101 tgctcatcga gtcctcgacg gaggtgctct ggatcccctt gcgctggtgg tccttctcgg
     2161 tccggccgag gcacggcagg atcagggccc ggcggccgtg gacgacgtgg ctgcggttca
     2221 gcttggtgct cacctgcacg gtcaggtcgc agttcgcgag cgccgcgtag gtgtacgggg
     2281 tgtccggcgc cgccagggcg aagttgccgc ccatgccgac gaacaccgtg acgtcgccgt
     2341 cgtgcatggc cgtgatcgtc cggacggtgt ccaggccgtg ctcgcggggc ggttcgatcc
     2401 cgcagacctc ggagaggcgg tcgaggaagg cctcgctcgg gcggtggtcg atgccgcagg
     2461 tgcggttgcc ctggacgttg ctgtggccgc ggacggggga ggggcccgcg ccctcgcggc
     2521 ccagattgcc gcgcagcagc aggacgttga cgatctcccg gaccgtgtcg acgccgtgct
     2581 cgtgctgggt gacgcccaga caccagctga cgatggaccg gtcggcctcc ccgtacacgc
     2641 gcgccgccgc gaggatgtcc gcgcggctca gcccggactg cctctccagc tgctcccacg
     2701 acgtcgcctc gcacaccgcg cggtactcgt cgaagccggc cgtgtgccgc tcgatgaact
     2761 cccggtccag cgccttgggg tcggtctccg actgctccag gatcgccttg gccatgccgc
     2821 gcagcagcgc catgtcgccg ccgatgcgcg gctggaggtt cagggtgctc gtcttcgtcg
     2881 tcttgaagag ggccatgtcg aggaagtcgt ggggcacgat cgtgcgggtc gcggccgcct
     2941 cgaccagtgg attgacgtgc acgatctgcg cgccgcggtg gtgcgcctcc gcgagggcgg
     3001 tgagcatccg gggcgcgttg gaggcggcgt tgacgcccag gatgaacagc gcgtcggcgg
     3061 actcccagtc cttcagatcg acggtcccct tgcccgtgcc cagcgaggcc tggagggcgc
     3121 ggccgctggc ctcgtggcac atgttggagc agtccggcag gttgttcgtg cccagttcgc
     3181 gggccatcag ctggtagagg aacgtcgcct cgttgccgag ccggccggag gtgtagaagg
     3241 ccgcccggtg ggggctgtcc agctcccgca gggtgcgccc gaccacatcg aaggcgtcct
     3301 tccagctgat cggcacgtag tggtccgtgt ccgggtcgta gaccatcggc tcggtcagcc
     3361 ggccctggtt ctccaggtcg tagtcgctcc acccggcaag ctcggtcacc gagtgcgcgg
     3421 cgaagaactc gcgcccgacc cgcttcctcg tcatctccca cgtgacgtgc ttgatgccgt
     3481 tctcgcagat gtcgaggtgc aggcccttgg tgtcgtcagg ccacgcgcag ccggggcagt
     3541 cgaacccggt gttctcgtgg ttcatcttca tgatcgcgcg ggggccgtcc acgagggcgc
     3601 cctcggcgag gaggaagcgg gtcacgctct tggccgcgcc ccagcccgcc gcggggtggt
     3661 ggtacgggtg gaactccggt tcgccctcgg gagtgggccc cacacgggcc tccggccgtt
     3721 ccgggtgccg gggacgttcc tggtcggtgt tgtcggcgct gtcggcgttc acgactctca
     3781 acccttccgg ccttcgggca cggggaggcg atacggctct cttcggcagg ctaggtccgg
     3841 tggtgggcgc ctgccactcg gccccgggag gccccgcgcg cctcggccgg ccgggcgggg
     3901 ccccacccgc gcctccgtcc ggccgggcgg tcccgtccgt acgcggatac gctggcgccg
     3961 ccccaatgat ctgttttgca actgtttgtc ttgttcgacg ggagtcccat ggtcgtcgcg
     4021 cagtccgtcc tcacgcccac ctccccgacg gccgtcttcg tggtggccac cgtgtccccc
     4081 ggtggggaga cggccgtacg ggaggtgctc caggacctgg ccgggctgac ccgttcggtg
     4141 gggttccggt ccccggagtc cgccctccgc tgcgtcgtcg gcgtgggctc ggacgcctgg
     4201 gaccggctcg tcggcggccc gcgcccgcgc gacctgcacc ccttcccgcc cctgcgtggc
     4261 ccccgccacc gtgccccggc cacccccggt gacctgctgt tccatctccg cgcccggcgc
     4321 atggacctct gcttcgaact ggcccggctg atcctggacc ggctgggcgg cgcggtgacg
     4381 gtcgtcgacg aggtccacgg cttcacgtac ttcgacgagc gcgacctgct cggcttcgtc
     4441 gacggcagcg agaacccctc cggcgaggcc gccgccgacg cggtccgcat cggcgacgag
     4501 gacccggact tccggggcgg aagctatgtc gtcgtgcaga agtacctgca cgacatgacg
     4561 gcctgggagt ccctcaccgt cgaggagcag gaacgcgtca tcggccgcac caagcaggcc
     4621 aacgtcgaac tgcccgacgg cgtcaagccc gccgactcgc acgtcgcgct caacacggtc
     4681 gtcgacgacg acggcgccga gcagcagatc ctgcgccaga acatgccgtt cggccaggtc
     4741 ggcagcggcg agatgggcac ctacttcatc ggctacgccc gcacgcccgc cgtcaccgag
     4801 cggatgctgc gcaacatgtt cctcggagat cccccgggca acaccgaccg catcctcgac
     4861 ttctcccgcg ccgtcaccgg ctgcctcttc ttcgtgccga gcgccgacct gctcgacgac
     4921 ctccccgccg ccccgtccgc ggccgccgcg agccccgggg actccctggg catcggcagc
     4981 ctgaaaggag cccccgcgtc atgacgactc ccgacgtgac gaacaacctg caccgggaac
     5041 tcgccccgat cacccccgcg gcctgggcgg agatcgagga ggaggcccgc cgtaccttcc
     5101 gccggcacgt cgccggccgc cgcgtcgtcg acgtaccgga cccggccggc cccgggctcg
     5161 ccgccgtcgg tgtcggccac ctgaccgaca tccacccgcc cgcgcccggc gtctcggcgc
     5221 ggttgcgcga ggcgaggccg atcgtcgaac tgcgggtgcc gttctccgtc tcccgggccg
     5281 ccgtggacga cgtcgagcgc gggtccaagg actccgactg gcagcccgtc aaggacgcgg
     5341 cgcgcacgat ggcgtacgtc gaggaccgca cgatcttcga cgggtacggc gccgccggtg
     5401 tcgacggact gcgctcccgc tcctcccacc cggtgctgcg gttgcccacc gaggcgcgag
     5461 agtaccccga cgccgtcagc cgggcgctga cgcagctgcg gctcgtcggc gtcgacgggc
     5521 cgtacgcgct gctgctcggc gccgacgagt accgggcggt cagcgagacc tccgaccacg
     5581 ggtacccgat cgccgcccat ctgggccgga tgctcgacgg ctcgccgatc tgggcaccgg
     5641 ccctcagcgg cggcttcgtc gtctccaccc ggggcggcga cttcgagctg ctgctcggcc
     5701 aggacgtggc gatcggctac acgggtcacg acgcgaccac catcgacctg tacttccacg
     5761 agacgctgac gttcctcacg tacacggacg aggccgtggt cgtcctggaa gcctgaccgt
     5821 gcaccggtgg ctggtcgacg ccgtcccccg gctcgtcgga gcgacggccg tgggggcggc
     5881 ggcgggcgtg ctcgtcggcc ttctctcgga cgcgccgctg ggcgcccttg ccggcatcgc
     5941 cgcggcggag gcgctcttcg tcgtcacggg ctggctcgtg ctctggccca tggacgcggc
     6001 caccacccat cgcaacgtcc ggcgggagga gttccggccg gtcgtcgagg aactcgtcgt
     6061 cgtcgggacc gccgtgtgcg gtctcgtcgg catcatcgtg atgctcctgg tcgggcagtc
     6121 gggcctgggc cacgccgccg ccgcgacggc gctcggcggc gtcttcacgg cctgggcggc
     6181 gctccacctg atgtacgcga cccgctacgc gtacgactac tacgccgtgg aacccggcgg
     6241 cgggatcgac ttcaacaccg acgacccgcc gcgctacagc gacttcctct acttcagctt
     6301 caacctcggc atgacctacc aggtctccga cacgaacgtc tcgcagtcgt cgctccgcgc
     6361 gatcgtcctc cggcactgcc tgctgtcgta cgtcttcggc gccagcatcc tggccaccac
     6421 catcaacctg gtcaccggca tcgtcacggg ctgagcaggt gatcaggcgc gccaccaggg
     6481 cagcgcgagg gcgagcgcga ccaggacggt gtgaccgggg ccgcccttgc ggccggcctg
     6541 ttccacctgt tcggcgtgcc ggtcccgggc ggtaccgccg cctatgacgg agcgcccttg
     6601 ccgtcgccgt caccgagcga cagcacgacc gcggtcgccg ggcccccggg cgtgtcgtac
     6661 gtgacggtgt cgccgacgcg gtggccgagg agcgcgctgc cgagggggct gtcggcggtg
     6721 accatggtcg cgtccaggac ctcggcgacc tcgccgatct ggacggtcgc ctccatggcg
     6781 tccgcgagcc gcagggtcac ggtgctgccg acgccgaccg tgtcggtgct cggcggtccg
     6841 gcgacggcgc cctcgcgcag ccgtccctcg atctcggcga tgcgggcgtc gaggtgctgg
     6901 agctccgtga cgcgctggag ttcgtcggcc tggtcggcgc ggtcgcccac ctgatcgccg
     6961 ccgccgtcgc gcaaggtcac ggcgaccgct tcgcgttcgg tgcgcaggtc ggcgagttcg
     7021 cgcgtgaacg cctcacgggc gacatcgctg aggggctcgg gtccaccggt catgtctgat
     7081 cccgtcgggc tgcgggcggc acgtgtgcgt gccgcgggtc ggtcacggca aaccgaaggt
     7141 atcaggcgaa acggggcatt tcgtcgctct cgaccttccg tcagggggtg ggtgttttct
     7201 ggcggttcga cgggagttcg attgcgggag tatggcagat gcatgacaag cctccaactc
     7261 ccttgagcta cgcccgtaga ccggacagtc tgctgatcac ccggagcgcc cacacggctc
     7321 cggaccgtgc gtgtgaccca cacgcgcccc ccacagtcgc gccgccccac acgaggcgcg
     7381 acgccgaaga ggaggactcc ctcgtatggc actcccgcag cgcaccaagg cccggctcgc
     7441 gctgaccgtc tccgccgcga ccgcggccgc cctgctcggc accttcgccg ccgtccccgc
     7501 ccaggcggcc cccgccgagg gcgtcgtcct cggggccggt tcggccgacg cggtgcccgg
     7561 cagctacatc gtcaccctga agcagggcgc gggcttcaag gccggctccg ccaagggccg
     7621 gaccctgata gccggctacg gcggcacggt ccgcaagacc ttcggctccg ccctcaacgg
     7681 ctacacggcc accctcggcg caacggaggc ccgccgcctc gcggccgacc ccgccgtcgc
     7741 ctccgtcgag cagaaccggg tcttccgtgc cgacgcgacg cagaccaacg ccccctgggg
     7801 cctggaccgc atcgaccagg cgaacctgcc gctcgacggc tcgtacacgt accccgactc
     7861 ggcgggcggc ggcgtcaccg cgtacgtcat cgacaccggc gtccgcatct cgcacgcaca
     7921 gctcggcggc agggccgtga acggctacga cgcggtcgac ggcgacaccg tcgcccagga
     7981 cggcaacggg cacggcacgc acgtcgccac caccatcgcg ggatcgacgt acggcgtggc
     8041 caaggccgcg aggatcgtcg ccgtccgcgt cctcgacaac gccggatccg gcaccaccgc
     8101 cggcgtcatc gcgggcatcg actgggtcac ctcccaccac acggcggggg ccccggccgt
     8161 cgccaacctc tccctcggcg gaggcgcctc caccgccctc gacaacgcgg tgaagaactc
     8221 catcgcggac ggcgtcacct acgccgtcgc cgcgggcaac tccggtgtca acgcctcctc
     8281 ctcgtccccc gcccgggtcg ccgccgccat cacggtcggc gccacgagca acacggacgc
     8341 caaggcgagc tggtccaact acggctcggt gctcgacctc ttcgcccccg gcgtgtcgat
     8401 caccgcgggc tggaacacga gcgacacggc caccaacacg atctcgggta cgtcgatggc
     8461 caccccgcac gtcgcgggcg ccgcggccgt ctacctcgcg gggcacccct ccgcgactcc
     8521 ggcgcaggtc gcgacggccc tcgtgaacgg cgcgaccccg aacaaggtga ccagcccggg
     8581 cagcggctcg cccaaccgcc tcctgcggat cgtcccgtaa cgcgcatgtg accggtcggg
     8641 ggtcttgcgc ggacccccga ccgtctctac cctcgcggct caatggttag gaaaacttcc
     8701 taacgaatgc atgaacgagt cgtgaaggaa agggagttgt catgcgtcga cgaagcgtct
     8761 cgcttctcgg gctcgccgga ttgctggtat tgcccctgac gtcggtgccg caggcactgg
     8821 cacaaccaca ggcccagccg cgcgcccagg accaggctgc cgccgccgac agcctggtct
     8881 ccgtcggcaa gccggtgacg gcctcgtccg tcgaggcctc ggggttcgag cccggcctgg
     8941 ccgccgacgg cagcgccacc accagatggg ccagcgcgga gggcgtcgac ccgcagtggg
     9001 tgcgcatcga cctcggcacg aaccacaccg tctcccgggt gaagctcaac tgggaggccg
     9061 cgtacggcaa ggcgtacaaa atacagacct cggccgacgg gtcgacctgg accgacgtct
     9121 acgcgaccac gaccggtgac ggcggcgtcg acgacctcgc ggtcaccggc agcggccgct
     9181 acctccgcat gcacgggacc gcgcgcggca cgccgtacgg ctactccctc tgggagttcg
     9241 aggtctacgg ctccccgagc ggcggcggcg tccccggcgg accggccgtc cccttcggca
     9301 gtcacctcaa gccctacgcc gccggcaccc tgaagccctc cggcgcccag gccacgatcg
     9361 accagaaggt cgtcgactac tacaacaagt ggaaggccgc cttcgtccgg cagaactgcg
     9421 gcaacggctg gtaccagatc atctcgcccg acgccgacca cccgtacgtc gccgaggccc
     9481 agggctacgg catggtcgtc accgcgacca tggccggcgc cgaccccgac gcgaagaaga
     9541 tcttcgacgg tctcgtgaag tggaagatcg accacccgtc cgcgatcaac ccgaacctcc
     9601 tcgcggccga acaggacgtc gcctgcaaga gcgtcaacgg cggcgacggc gccaccgacg
     9661 gcgacatgga cgtggcctac ggcctgctcc tcgccgacaa gcagtggggg agcgccggca
     9721 cgtacaacta caaggacctc gcgctcaagc acatcgccgc gatcaagaag gacgagctca
     9781 acccgacgac caagctcctg aagctgggcg actggagcag ctccggcgac cagtactact
     9841 acatctcccg cacctcggac tggatggtcg accacttccg cgccttccgt acggcctccg
     9901 gcgacacgac ctgggacgcc gtgcgcaccg cgcaccagac ccagatcacg cgcctccagt
     9961 cgacgtacgc ctcgggcacc ggcctgctgc ccgacttcgt cgtcgacacg aacaccacgc
    10021 ccaagcccgc ccccggccag gtcctggagg acccgaacga cggcgcgtac tggtggaacg
    10081 cgtgtcgcac cccgtggcgc atcgccgacg acgcggtgac cagcggggac gccggctcgc
    10141 tcgccgccgc gcggaagctc aacagctgga tcaagacgaa gaccggcggc gacccgaaca
    10201 agatcgccat cggctacaag ctcaacggca cccagatttc ggcgggcagc gaggcggcct
    10261 tcttcgcgcc gttcgccgtg gccgccatga ccgacccggg cagccaggcc tggctggacg
    10321 ccctctggaa caagatgctg gtcacgccgg tcgacaccag cagctacttc tcggccagca
    10381 tccagctcca ggtcatgatc acggcctcgg ggaaccactg ggtcccgtag gcccgtaggg
    10441 gccgctccga tcagtggtgg aagagccgca gtccggtgcg ggcgagcgtg atgccgtgct
    10501 cgcggcaggc gtcctccaca tcggcggagc ggatcgaccc gccgggttcg gcgatgaagc
    10561 cgacgccgtg ccggtgcgcg tggtcgacgt tgtcgcggaa gggcagagcg ccgtccgagg
    10621 cgaacgccac cccggtcagc tcggccagcc actcggtgcg ctgctcgtcg gtgaggtcgg
    10681 gggcgggcac ggacaggact ccggacaggc gcgcgcgctc gtccggggtg aggtcgccct
    10741 cgacgaaccg gatccgccag ttgatccggt cctggcggcg gacgcccggc cggaaggcga
    10801 gcgcgcggac ggcggg
//
