LOCUS       NZ_LMEI01000004        24265 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces sp. Root431 contig_12, whole genome shotgun sequence.
ACCESSION   NZ_LMEI01000004
VERSION     NZ_LMEI01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root431
  ORGANISM  Streptomyces sp. Root431
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 24671)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 24671)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140605
            Assembly Name                     :: Root431
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426585.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 02:21:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,904
            CDSs (total)                      :: 5,829
            Genes (coding)                    :: 5,744
            CDSs (with protein)               :: 5,744
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 22 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 1 of 85
            Pseudo Genes (multiple problems)  :: 10 of 85
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:56:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 406
            Orig. end                         :: 24671
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEI01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24265
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..24265
                     /SMILES="C(C)C(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24265
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20000:22886](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..22886)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     misc_feature    complement(160..176)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            991..>1155
                     /locus_tag="ASC82_RS04340"
                     /old_locus_tag="ASC82_29010"
                     /pseudo=""
     CDS             991..>1155
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013781.4"
                     /locus_tag="ASC82_RS04340"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29010"
                     /product="methylmalonyl-CoA mutase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MCAESADAGSGHTGSAYAGSGTARESNARYKRLIADGTPGLTVAF
                     DLPTRMGRDS"
     gene            complement(1368..4154)
                     /locus_tag="ASC82_RS04345"
                     /old_locus_tag="ASC82_29015"
     CDS             complement(1368..4154)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="ASC82_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29015"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_079039034.1"
                     /transl_table=11
                     /translation="MNLVERDGEIAHLGAVLDASAAGDGTLLLVSGPAGSGKTELLRSL
                     RRLAAERGTPVWTVRALPGDRDVPLGVLCQLLRSAEQHGADTSTVRDLVDGASRRAGNL
                     TSPADAPLRVDETHRLHDWLLSVARGTPFLIAVDDLTHADTASLRFILHCAAHPDQGGI
                     GFVLTERASQRAGYRVFRAELLRQPHCRSMWLAGLPPSGVRRFLAHHYGPEAAERRAPA
                     YHAATGGNPLLLRALTQDRQAARTTLGGAGGDDPVHGDAFAQAVLDCLHRSTEGTLETA
                     RWLAVLEQADPLLVERLTGATATAVERHLLELGAIGLLGEDGTLGHPAIREAALQDLPA
                     ADRTELHRRAAEQLHRDGADEDTVARHLLVGGAPDAPWALPLLERGAQQALFDDRLDDA
                     FRILEFAVRSSTDNTQLARLAPHLVAASWRMNPHMTTRALALFDRLLGGELPPSHPVMA
                     LIRCLVWYGRLPEAADALSRLRPGTDSENLELSLTRMWLAALCPPLLESLPDAPEPERG
                     PVPVRLAPRTTALQAQAGVFQRGPDNASVAQAEQILQGCRLSEDTYEALETALLVLVHA
                     DRLDRALFWSDALLAEASERRSLGWEAVFAATRAMIAVRCGDLPTARERAELALSHAAP
                     ESWGLAVGVPLSALLLACTEAGEYEQAERVLRQPVPDAMFDSRHGMEYMHARGRYWLAT
                     GRLHAALGEFMLCGEILGSWNLDQPSIVPWRTSAAEVYLRLGNRQKARALAEAQLALVR
                     PGRSRTRGLTLRVLAAAADGQQAERLHAEAVDMLHDSGDRLEHARALAGMSRHQQAQGD
                     NYRARMTARLAGDMAWACGAYPLAEEIVPGRGGRRAKAVSPDLELPGGPDVGLLSEAER
                     RVAALAARGLTNRQIARRLCVTASTVEQHLTRVYRKLNVTRRADLPVSLAQDKSVTA"
     misc_feature    complement(4071..4073)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4186..4206
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.6"
                     /tool="antismash"
     gene            complement(4290..5537)
                     /locus_tag="ASC82_RS04350"
                     /old_locus_tag="ASC82_29020"
     CDS             complement(4290..5537)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983112.1"
                     /locus_tag="ASC82_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29020"
                     /product="cytochrome P450"
                     /protein_id="WP_056641832.1"
                     /sec_met_domain="p450 (E-value: 6.2e-32, bitscore: 101.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTHEGTTASPPVLDLAALGKDFAADPYPTYARLRAEGPAHRVRT
                     PDGDEVWLVVGYEQARAVLTDPRFSKDWRNSSTVLTEAETQVNQNMLESDPPRHTRLRK
                     LVAREFTMRRVELLRPRVQEIVDGLMDAMLAAPDGRADLMEALAWPLPITVISELLGVP
                     EPERAAFRVWTDAFVFPDDPAEAQTAMAEMSRYLSRLIDSKRGVQGEDLLSALVRTSDE
                     DGSRLTPEELLGMAHILLVAGHETTVNLITNGMYALLSHPDQLSALRADMTLLDGAVEE
                     MLRYEGPVESATYRFPVEPVDLDGTVIPAGDKVLVVLADAHRTPERFPDPHRFDIRRDT
                     SGHLAFGHGIHFCLGAPLARMEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKA
                     LPVRWRRGREAGGRTG"
     misc_feature    complement(5711..5726)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            5900..7126
                     /locus_tag="ASC82_RS04355"
                     /old_locus_tag="ASC82_29025"
     CDS             5900..7126
                     /NRPS_PKS="Domain: Aminotran_1_2 (52-228). E-value: 3e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04355_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554530.1"
                     /locus_tag="ASC82_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29025"
                     /product="dTDP-4-dehydro-6-deoxyglucose aminotransferase"
                     /protein_id="WP_056641834.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.7e-108,
                     bitscore: 351.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.1e-12, bitscore:
                     34.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSALSDLAFFGGPAAFDQPLLVGRPNRIDRAKLYERLDRALDGQ
                     WLSNGGPLVREFEERVADLAGVRHAVAVCNATAGLQLLAHAAGLTGEVIMPSMTFAATP
                     HAMRWIGLTPVFVDIDPDTGNLDPEQVAAAVTPRTSAVVGVHLWGRPCAADQLRKVADE
                     HGLRLFFDAAHALGCAIDGRPAGSLGDAEVFSFHATKAVNAFEGGAIVTGDADLADRMR
                     ALHNFGFGLPGGSPAGGTNAKMSEANAAMGLTSLDAFPEVIARNRANHAAYRTQLEGIP
                     GVLVADHDRHGVNNHQYVIVEIDEEITGIHRDLVMDVLKAEGIHTRAYFSPGCHQLEPY
                     RGQPHAPLPHTERLAERVLSLPTGTAVDEDDIRRVGDVLRFCATRGHELTARHRDPADA
                     AVAPRAARP"
     misc_feature    5912..5914
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        6056..6583
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04355_Aminotran_1_2.1"
                     /evalue="3.00E-11"
                     /label="ASC82_RS04355_Aminotran_1_2.1"
                     /locus_tag="ASC82_RS04355"
                     /protein_end="228"
                     /protein_start="52"
                     /score="34.9"
                     /tool="antismash"
                     /translation="LVREFEERVADLAGVRHAVAVCNATAGLQLLAHAAGLTGEVIMPS
                     MTFAATPHAMRWIGLTPVFVDIDPDTGNLDPEQVAAAVTPRTSAVVGVHLWGRPCAADQ
                     LRKVADEHGLRLFFDAAHALGCAIDGRPAGSLGDAEVFSFHATKAVNAFEGGAIVTGDA
                     DLADRMRALHNFG"
     gene            7182..8639
                     /gene="desII"
                     /locus_tag="ASC82_RS04360"
                     /old_locus_tag="ASC82_29030"
     CDS             7182..8639
                     /EC_number="4.3.1.30"
                     /codon_start=1
                     /gene="desII"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741987.1"
                     /locus_tag="ASC82_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29030"
                     /product="dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase"
                     /protein_id="WP_056641836.1"
                     /transl_table=11
                     /translation="MTAPAPAATAPAERCAHPGADLGAAAHAVGQTLVAGGLVPSDEAG
                     TTARHLVRLAVRYGNSPFTPLEEARRDLGVDRDAFRRLLALFGQLPELRVAVETGPAGA
                     YWKNTLLPLEQRGVFDAALAGKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPSALDS
                     GNAMFRSVIDEIPTGNPFALYFSGGLEPLTNPGLGTLAAHAVQHGLRPTVYTNSFALTE
                     RTLERQPGLWDLHAVRTSLYGLNDEEYEQTTGKKAAHTRVRENLRRFQKARAERESPIN
                     LGFAYIVLPGRASRLLDLVDFIADLNEAGQGRTIDFVNIREDYSGRDDGKLPQQERAEL
                     QEALAAFEARVNERTPGLHIDYGYALNSLRAGADAELLRIKPETMRPTAHPQVAVQVDL
                     LGDVYLYREAGFPDLDGATRYIAGRVTPDTSLTEVVRDFVERRGQVEARDGDEYFMDGF
                     DQVVTARLNQLERDAADGWEDVRGFLR"
     gene            8811..9689
                     /gene="rfbA"
                     /locus_tag="ASC82_RS04365"
                     /old_locus_tag="ASC82_29035"
     CDS             8811..9689
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rfbA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037177.1"
                     /locus_tag="ASC82_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29035"
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="WP_056641840.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.8e-12, bitscore:
                     37.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPATSVISKQILPVYNKPMIYYPLSVLMLGG
                     IREIQIISTPQHIELFQSLLGDGSHLGIELDYAVQKEPAGIADALLVGAGHIGDDSCAL
                     ILGDNIFHGPGLYTLLRDSIARLDGCVLFGYPVKDPERYGVAEVDAEGRLTGLVEKPEK
                     PRSNLAVTGLYLYDNDVVDIAKNIRPSARGELEITDVNRVYMERGRAELVDLGRGFAWL
                     DTGTHDSLLRAAQYVQVLEERQGVWIAGLEEIAFRMGFIDAEACHGLGERLSRTEYGTY
                     LMEIAGREGTP"
     gene            9826..10839
                     /gene="rfbB"
                     /locus_tag="ASC82_RS04370"
                     /old_locus_tag="ASC82_29040"
     CDS             9826..10839
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-180). E-value: 6.9e-18.
                     Score: 56.6. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04370_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982384.1"
                     /locus_tag="ASC82_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29040"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_056641842.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.8e-18, bitscore:
                     56.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-17,
                     bitscore: 53.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.1e-18, bitscore:
                     56.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNR
                     ANLAPVDGDPRLRFVHGDIRDAGLLARELPGVDAIVHFAAESHVDRSIAGASVFTETNV
                     QGTQTLLQCAVDAGVGRVVHVSTDEVYGSIDSGSWTESSPLEPNSPYAASKAGSDLVAR
                     AYHRTYGLDVRITRCCNNYGPYQHPEKLIPLFVTNLLDGGTLPLYGDGANVREWVHTDD
                     HCRGIALVLAGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSSVRKVADRKGHDLRY
                     SLDGGKIERELGYRPQVAFADGLARTVRWYRENRDWWEPLKTPAPELPAATAGVPA"
     CDS_motif       9835..9897
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04370_0001"
                     /evalue="4.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASC82_RS04370"
                     /protein_end="24"
                     /protein_start="3"
                     /score="9.8"
                     /tool="antismash"
                     /translation="LVTGGAGFIGSHFVRQLLAGA"
     aSDomain        9838..10365
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04370_NAD_binding_4.1"
                     /evalue="6.90E-18"
                     /label="ASC82_RS04370_NAD_binding_4.1"
                     /locus_tag="ASC82_RS04370"
                     /protein_end="180"
                     /protein_start="4"
                     /score="56.6"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLA
                     PVDGDPRLRFVHGDIRDAGLLARELPGVDAIVHFAAESHVDRSIAGASVFTETNVQGTQ
                     TLLQCAVDAGVGRVVHVSTDEVYGSIDSGSWTESSPLEPNSPYAASKAGSDLVARAYHR
                     TYGLDVRITRCCN"
     gene            10836..11984
                     /locus_tag="ASC82_RS04375"
                     /old_locus_tag="ASC82_29045"
     CDS             10836..11984
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (45-219). E-value:
                     1.5e-07. Score: 22.8. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04375_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467342.1"
                     /locus_tag="ASC82_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29045"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_056641845.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.2e-126,
                     bitscore: 413.0, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.5e-08, bitscore:
                     22.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTRVPTPRVPFLDLKAAYDELRAETDAAIARVLDSGRYLLGPEL
                     EGFENEFAAYCETDHAVGVNSGMDALQLALRGLGIGPGDEVIVPSHTYIASWLAVTATG
                     ATPVPVEPREDHPTLDPLLVEKAITPRTKALLPVHLYGHPADMDALRDLAARHDLHIVE
                     DAAQAHGARYRGRRIGSGSSVAAFSFYPGKNLGCFGDGGAVVTGDPELAERLRMLRNYG
                     SRQKYSHEMKGTNSRLDEMQAAVLRIRLAHLDAWNGRRSALAAEYLSGLAGLPGIALPV
                     TAPDTDPVWHLFTVRTERRDELRDHLDARGIDTLTHYPVPVHLSAAYAGDALPAGPLPE
                     GSLPRAESFARQVLSLPIGPHLERAQALRVVEAVREWAVNAG"
     aSDomain        10971..11492
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04375_Aminotran_1_2.1"
                     /evalue="1.50E-07"
                     /label="ASC82_RS04375_Aminotran_1_2.1"
                     /locus_tag="ASC82_RS04375"
                     /protein_end="219"
                     /protein_start="45"
                     /score="22.8"
                     /tool="antismash"
                     /translation="EGFENEFAAYCETDHAVGVNSGMDALQLALRGLGIGPGDEVIVPS
                     HTYIASWLAVTATGATPVPVEPREDHPTLDPLLVEKAITPRTKALLPVHLYGHPADMDA
                     LRDLAARHDLHIVEDAAQAHGARYRGRRIGSGSSVAAFSFYPGKNLGCFGDGGAVVTGD
                     PELAERLRMLR"
     gene            complement(12063..14549)
                     /locus_tag="ASC82_RS04380"
                     /old_locus_tag="ASC82_29050"
     CDS             complement(12063..14549)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638343.1"
                     /locus_tag="ASC82_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29050"
                     /product="glycoside hydrolase family 3 C-terminal
                     domain-containing protein"
                     /protein_id="WP_242427545.1"
                     /transl_table=11
                     /translation="MTGKSRIPRVRRGRTSPRAFTLAVVGTLLAGTTVAAAAPGTAGAA
                     NVQYTTRAAELVAQMTLDEKISFVHWALDPDRQNVGYLPGVPRLGIPELRAADGPNGIR
                     LVGKTATALPAPVALASTFDDTMADSYGKVMGRDGRALGQDMVLGPMMNNIRVPHGGRN
                     YETFSEDPLVSSRTAVAQIKGIQGAGLMTTAKHFAANNQENNRFSVNATVDEQTLREIE
                     FPAFEASSKAGAASFMCAYNGLNGKPSCGNDELLNNVLRTQWGFQGWVMSDWLATPGTD
                     AITKGLDQEMGVELPGDIPPGEPSPPAKFFGDALKTAVLNGTIPESAVTQSAERIVNQM
                     DKFGLLLATPAPRPERDKAGAQAVSRKVAENGAVLLRNEGQALPLAGDAGKSIAVIGPT
                     AVDPKVTGLGSAHVVPDSAAAPLDTIKARAGAGATVTYETGEETFGTQIPAANLSPAFN
                     QGVQLQPGQAGALYDGTLTVPADGEYRIAVRATGGYATVQLGSHTIEAGQVYGKVSSPL
                     LKLTKGTHKLTISGFAMSATPLSLELGWVTPQAADATIAKAVESAKKARTAIVFAYDDG
                     TEGVDRPNLSLPGTQDKLISAVADANPNTIVVLNTGSSVLMPWLSKTRAVLDMWYPGQA
                     GAEATASLLYGDVNPSGKLTQSFPAAENQHAVAGDPNRYPGVDNQQQYTEGIHVGYRWF
                     DKENVKPLFPFGHGLSYTSFTQSAPTVVRTTTGGLKVTVTVRNSGQRAGQEVVQAYLGA
                     SPNVTAPQAKKKLVGYTKVSLAAGESKTVTINVDRRQLQFWDAAADCWKTGTGNRLLQT
                     GSSSADLRGSATVNVW"
     gene            complement(14666..15382)
                     /locus_tag="ASC82_RS04385"
                     /old_locus_tag="ASC82_29055"
     CDS             complement(14666..15382)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641175.1"
                     /locus_tag="ASC82_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29055"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_056641847.1"
                     /transl_table=11
                     /translation="MSYEVDHADVYDLFYLGRGKDYAAEASDIADLVRSRTPEASSLLD
                     VACGTGTHLEHFTKEFGDTAGLELSEDMLNHARTRLPDATLHQGDMRDFRLGRRFSAVV
                     SMFSSVGYLRTTDELDAAVASFAEHLEPGGVVVVEPWWFPETFADGWVSADVVRRDGRT
                     VARVSHSVREGDATRMEVHFTVADPGKGVRHFSDVHLITLFHQAQYEAAFTAAGLRVEY
                     LEGGPSGRGLFVGVPA"
     gene            complement(15439..16719)
                     /locus_tag="ASC82_RS04390"
                     /old_locus_tag="ASC82_29060"
     CDS             complement(15439..16719)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743407.1"
                     /locus_tag="ASC82_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29060"
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_056641850.1"
                     /sec_met_domain="MGT (E-value: 2.8e-148, bitscore: 484.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLTSFAHHTHYYGLVPLAWALLAAGHEVRVASQPALTDTITG
                     SGLAAVPVGTDHLIHEYRVRMAGEPRPNHPAIAFDEARTEPLDWDHALGIEAILAPYFY
                     LLANNDSMVDDLVDFARSWQPDLVLWEPTTYAGAVAAQVTGAAHARVLWGPDVMGSARR
                     KFVALRDRQPPEHREDPTAEWLTWTLDRYGASFEEELITGQFTVDPTPPSLRLDTGLPT
                     VGMRYVPYNGTSVVPDWLSEPPARPRVCLTLGVSAREVLGGDGVSQGDILEALADLDIE
                     LIATLDASQRAEIRNYPKHTRFTDFVPMHALLPSCSAIIHHGGAGTYATAVINAVPQVM
                     LAELWDAPVKARAVAEQGAGFFLPPAELTPQAVRDAVVRILDDPSVTTAAHRLRDETYR
                     DPTPAGIVPELERLAAQHRRPPADARP"
     misc_feature    complement(16681..16697)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            complement(16797..18065)
                     /locus_tag="ASC82_RS04395"
                     /old_locus_tag="ASC82_29065"
     CDS             complement(16797..18065)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04515.1"
                     /locus_tag="ASC82_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29065"
                     /product="P450-derived glycosyltransferase activator"
                     /protein_id="WP_079039035.1"
                     /sec_met_domain="p450 (E-value: 4.1e-16, bitscore: 48.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPTVSDDLTGALTQPPLGRTVRAVADRELGTHLLETRGIHWIH
                     AANGDPYAAVLRGQSDDPYPEYERLRARGPLSFSPTGSWVVSGHALAASVLSSADFGVS
                     GADGGPVAQQVLSYGEGCPLEHERGLPAARGAAESGDRAVVERVHRETLEGLVPDPSAS
                     YAFELVGGFVRPAVTAATAAVLGVPSDRRAEFGALVEQLRPLSDSLLAPQSLRTVRAAD
                     DALAALTVLLADSAADSSADAAADAPAGSLRPDGALLSALGVSAAVRLTGNAVLALLAH
                     PGQWKELCERPGLAPAAVEETLRYDPPVQLDARVVRTETELAGRRLPVGAHVVVLTAAA
                     GRDPEVFADPERFDLARPDAAAHLALHPAGPYGPVASLVRLQAEVALRTLAGRFPGLRQ
                     AGPVLHPRRAPVGRGPLSVPVSA"
     gene            complement(18047..18892)
                     /locus_tag="ASC82_RS04400"
                     /old_locus_tag="ASC82_29070"
     CDS             complement(18047..18892)
                     /NRPS_PKS="Domain: Thioesterase (25-251). E-value: 1.3e-58.
                     Score: 191.1. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04400_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128122.1"
                     /locus_tag="ASC82_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29070"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_199862462.1"
                     /sec_met_domain="Thioesterase (E-value: 2.3e-57, bitscore:
                     185.0, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.9e-12, bitscore:
                     36.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRSLNVDSSLWIRRFHPSPHSTVRLVCLPHAGGSASYFFRFSE
                     ELHPSVEALSVQYPGRQDRRAEPCLESVEELAEHVVAATERWWQEGGLAFFGHSLGASV
                     AYEAARILEQRHGVKPEGLYVSGRRAPSLAPAGLVHQLDDRAFLAEIRRLSGTDDRFLQ
                     DDELMRMVLPALRSDYKAAETYEHRPSAKLACPVMALAGDRDPKAPLNEVAEWRRHTNG
                     PFCLRAYSGGHFYLNDQWHEICNDISDHLLVTRCAPDPRVVQPPTSLIEGAAKRWQNPR
                     "
     aSDomain        complement(18140..18817)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04400_Thioesterase.1"
                     /evalue="1.30E-58"
                     /label="ASC82_RS04400_Thioesterase.1"
                     /locus_tag="ASC82_RS04400"
                     /protein_end="251"
                     /protein_start="25"
                     /score="191.1"
                     /tool="antismash"
                     /translation="RLVCLPHAGGSASYFFRFSEELHPSVEALSVQYPGRQDRRAEPCL
                     ESVEELAEHVVAATERWWQEGGLAFFGHSLGASVAYEAARILEQRHGVKPEGLYVSGRR
                     APSLAPAGLVHQLDDRAFLAEIRRLSGTDDRFLQDDELMRMVLPALRSDYKAAETYEHR
                     PSAKLACPVMALAGDRDPKAPLNEVAEWRRHTNGPFCLRAYSGGHFYLNDQWHEICNDI
                     SDHL"
     CDS_motif       complement(18557..18622)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04400_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="ASC82_RS04400"
                     /protein_end="112"
                     /protein_start="90"
                     /score="19.8"
                     /tool="antismash"
                     /translation="GGLAFFGHSLGASVAYEAARIL"
     gene            complement(18889..20097)
                     /locus_tag="ASC82_RS29840"
                     /old_locus_tag="ASC82_29075"
     CDS             complement(18889..20097)
                     /NRPS_PKS="Domain: ACP (1-71). E-value: 2e-29. Score: 93.7.
                     Matches aSDomain: nrpspksdomains_ASC82_RS29840_ACP.1"
                     /NRPS_PKS="Domain: Thioesterase (180-389). E-value:
                     5.9e-31. Score: 100.6. Matches aSDomain:
                     nrpspksdomains_ASC82_RS29840_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="ASC82_RS29840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29075"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_056641854.1"
                     /sec_met_domain="PP-binding (E-value: 3.7e-17, bitscore:
                     52.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 3.7e-26, bitscore:
                     82.9, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-09, bitscore:
                     29.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLRQAAAALGHDTPDELPADRPLRELGFDSLTAVELRNRINRLA
                     GLQLPATAVFEHPTPAALADRVSGELAERGWAVAEPRTEERPTAPTTPQSTTAPRRSPG
                     ATPGADGGMFRALFRQAVEDGRYSEFLGVLAEASSFRPQFATPEDCAERLDPVLLAGAP
                     ADRAGGRTLLVGCTGTAANGGPQEFLRLSASFQEERDFLALPLPGYGTGTGTGTALLPA
                     DLDTALDAQALALLRAAGDAPVVLVGHSGGALLAHELAFRLDRAHGAPPAGIVLVDPYP
                     PGHQEPVEAWSRQLGEGLFAGELEPMADSRLLAMGRYARFLADARPGRSSAPVLLVRAS
                     EPLGEWSEERGDWRAHWDLPHTVVDVPGDHFTMMRDHAPAVADAVISWLDAVERGTAQG
                     ADQ"
     aSDomain        complement(18931..19557)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS29840_Thioesterase.1"
                     /evalue="5.90E-31"
                     /label="ASC82_RS29840_Thioesterase.1"
                     /locus_tag="ASC82_RS29840"
                     /protein_end="389"
                     /protein_start="180"
                     /score="100.6"
                     /tool="antismash"
                     /translation="ANGGPQEFLRLSASFQEERDFLALPLPGYGTGTGTGTALLPADLD
                     TALDAQALALLRAAGDAPVVLVGHSGGALLAHELAFRLDRAHGAPPAGIVLVDPYPPGH
                     QEPVEAWSRQLGEGLFAGELEPMADSRLLAMGRYARFLADARPGRSSAPVLLVRASEPL
                     GEWSEERGDWRAHWDLPHTVVDVPGDHFTMMRDHAPAVADAVISWL"
     aSModule        complement(18931..22775)
                     /complete
                     /domains="nrpspksdomains_ASC82_RS04410_PKS_KS.1"
                     /domains="nrpspksdomains_ASC82_RS04410_PKS_AT.1"
                     /domains="nrpspksdomains_ASC82_RS29840_ACP.1"
                     /domains="nrpspksdomains_ASC82_RS29840_Thioesterase.1"
                     /final_module
                     /locus_tags="ASC82_RS04410"
                     /locus_tags="ASC82_RS29840"
                     /monomer_pairings="mmal -> Me-mal"
                     /monomer_pairings="mmal -> Me-mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(19309..19377)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS29840_0001"
                     /evalue="3.90E-06"
                     /label="NRPS-te1"
                     /locus_tag="ASC82_RS29840"
                     /protein_end="263"
                     /protein_start="240"
                     /score="19.4"
                     /tool="antismash"
                     /translation="DAPVVLVGHSGGALLAHELAFRL"
     aSDomain        complement(19885..20094)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS29840_ACP.1"
                     /evalue="2.00E-29"
                     /label="ASC82_RS29840_ACP.1"
                     /locus_tag="ASC82_RS29840"
                     /protein_end="71"
                     /protein_start="1"
                     /score="93.7"
                     /tool="antismash"
                     /translation="VLRQAAAALGHDTPDELPADRPLRELGFDSLTAVELRNRINRLAG
                     LQLPATAVFEHPTPAALADRVSGEL"
     gene            complement(20001..22886)
                     /locus_tag="ASC82_RS04410"
                     /old_locus_tag="ASC82_29080"
     CDS             complement(20001..22886)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (37-463). E-value:
                     8.6e-175. Score: 573.6. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04410_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (560-804). E-value: 2.4e-92.
                     Score: 301.4. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04410_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012337.4"
                     /locus_tag="ASC82_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29080"
                     /product="type I polyketide synthase"
                     /protein_id="WP_347336067.1"
                     /sec_met_domain="mod_KS (E-value: 3.7e-220, bitscore:
                     721.3, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 4e-87, bitscore:
                     282.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7.3e-93, bitscore: 301.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSNEQLVDALRASLKENEELRKESRRQDDRRQEPMAIVGMSCR
                     FAGGIGSPEDLWDAVAAGKDLVSDVPEERGWDIESLYDPEPGRKGTTYVRNAAFLDDAA
                     GFDAGFFGISPREALAMDPQQRQLLEASWEVFERAGIDPASVRGTDVGVYVGCGYQDYA
                     PDIRVAPEGTGGYVVTGNSSAVASGRIAYSLGLEGPAVTVDTACSSSLVALHLALKGLR
                     NGDCSTALVGGVAVLATPGAFIEFSRQQAMAADGRTKGFASAADGLAWGEGVAVLLVER
                     LSDARRKGHRVLAVVRGSAINQDGASNGLTAPHGPSQQRLIRQALADARLTSRDVDVVE
                     GHGTGTRLGDPIEAQALLATYGQGRSPGQPLRLGTVKSNIGHTQAASGLAGVIKMVQAM
                     RHGVLPKTLHVDEPTDQVDWTAGEVELLTEAVDWPAQPGRPRRAGVSAFGVGGTNAHVV
                     LEEAPTTEAARAVESPAGVVPWLVSAKTPAALDAQIGRLAAYADSRTDLGPAVAARTLL
                     DGRTAMEYRAVAVGDSREALRDALRMPEGLVRGTASDLGRVAFVFPGQGTQWAGMGAEL
                     LDVSKEFAEAMAECETALSPYVDWSLEAVVRQTPGAPSLERVDVVQPVTFAVMVSLARV
                     WQHYGVTPQAVIGHSQGEIAAAYVAGALTLDDAARVVALRSQSIAAHLAGKGGMISLAL
                     SEEATQQRIENLDSLSVAAVNGPTVTVVAGDPAQIQELADACEADGVRARIIPVDYASH
                     SAHVEIIEEDLAKVLAGLTPQAPRVPFFSTLEGSWITEAALDGAYWYRNLRPTKASPTS
                     SKSAPTPSSPWPSPRPSPDSAPSAATRADRPGSSPPWPKPGPTASPSTGLPTSLPRPPT
                     PTSPPTPSSTAPTGSTPRPPVKRPRTPLPRARPRPRPDRRGVSTSPISTRKGGAASSSP
                     WCCGRRPPRSGTTRPTSSPPTGPCGSSASTR"
     aSDomain        complement(20475..21206)
                     /ASF="Methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04410_PKS_AT.1"
                     /evalue="2.40E-92"
                     /label="ASC82_RS04410_PKS_AT.1"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="804"
                     /protein_start="560"
                     /score="301.4"
                     /specificity="substrate consensus: mmal"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFPGQGTQWAGMGAELLDVSKEFAEAMAECETALSPYVDWSLEAV
                     VRQTPGAPSLERVDVVQPVTFAVMVSLARVWQHYGVTPQAVIGHSQGEIAAAYVAGALT
                     LDDAARVVALRSQSIAAHLAGKGGMISLALSEEATQQRIENLDSLSVAAVNGPTVTVVA
                     GDPAQIQELADACEADGVRARIIPVDYASHSAHVEIIEEDLAKVLAGLTPQAPRVPFFS
                     TLEGSWITEAALDGAYWYRNLR"
     CDS_motif       complement(20613..20645)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0008"
                     /evalue="3.40E-04"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="758"
                     /protein_start="747"
                     /score="13.3"
                     /tool="antismash"
                     /translation="VDYASHSAHVE"
     CDS_motif       complement(20715..20753)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0007"
                     /evalue="5.00E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="724"
                     /protein_start="711"
                     /score="10.3"
                     /tool="antismash"
                     /translation="AAVNGPTVTVVAG"
     CDS_motif       complement(20859..20969)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0006"
                     /evalue="5.60E-20"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="676"
                     /protein_start="639"
                     /score="63.1"
                     /tool="antismash"
                     /translation="GVTPQAVIGHSQGEIAAAYVAGALTLDDAARVVALRS"
     CDS_motif       complement(20976..21044)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0005"
                     /evalue="2.20E-10"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="637"
                     /protein_start="614"
                     /score="32.5"
                     /tool="antismash"
                     /translation="LERVDVVQPVTFAVMVSLARVWQ"
     CDS_motif       complement(21156..21209)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0004"
                     /evalue="3.80E-09"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="577"
                     /protein_start="559"
                     /score="28.2"
                     /tool="antismash"
                     /translation="FVFPGQGTQWAGMGAELL"
     aSDomain        complement(21498..22775)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04410_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="8.60E-175"
                     /label="ASC82_RS04410_PKS_KS.1"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="463"
                     /protein_start="37"
                     /score="573.6"
                     /tool="antismash"
                     /translation="AIVGMSCRFAGGIGSPEDLWDAVAAGKDLVSDVPEERGWDIESLY
                     DPEPGRKGTTYVRNAAFLDDAAGFDAGFFGISPREALAMDPQQRQLLEASWEVFERAGI
                     DPASVRGTDVGVYVGCGYQDYAPDIRVAPEGTGGYVVTGNSSAVASGRIAYSLGLEGPA
                     VTVDTACSSSLVALHLALKGLRNGDCSTALVGGVAVLATPGAFIEFSRQQAMAADGRTK
                     GFASAADGLAWGEGVAVLLVERLSDARRKGHRVLAVVRGSAINQDGASNGLTAPHGPSQ
                     QRLIRQALADARLTSRDVDVVEGHGTGTRLGDPIEAQALLATYGQGRSPGQPLRLGTVK
                     SNIGHTQAASGLAGVIKMVQAMRHGVLPKTLHVDEPTDQVDWTAGEVELLTEAVDWPAQ
                     PGRPRRAGVSAFGVGGTNAHVVLEEAP"
     CDS_motif       complement(21723..21767)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0003"
                     /evalue="1.50E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="388"
                     /protein_start="373"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GTVKSNIGHTQAASG"
     CDS_motif       complement(21828..21872)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0002"
                     /evalue="1.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="353"
                     /protein_start="338"
                     /score="11.5"
                     /tool="antismash"
                     /translation="VEGHGTGTRLGDPIE"
     CDS_motif       complement(22248..22295)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04410_0001"
                     /evalue="4.30E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="ASC82_RS04410"
                     /protein_end="213"
                     /protein_start="197"
                     /score="21.7"
                     /tool="antismash"
                     /translation="GPAVTVDTACSSSLVA"
     CDS             complement(22953..>24261)
                     /NRPS_PKS="Domain: PKS_KR (0-166). E-value: 1.4e-49. Score:
                     160.4. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04415_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (275-347). E-value: 1.1e-32. Score:
                     104.1. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04415_ACP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (359-432). E-value:
                     4.4e-11. Score: 35.5. Matches aSDomain:
                     nrpspksdomains_ASC82_RS04415_PKS_Docking_Cterm.1"
                     /codon_start=3
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020243.4"
                     /locus_tag="ASC82_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_29085"
                     /product="beta-ketoacyl reductase"
                     /protein_id="WP_157863432.1"
                     /sec_met_domain="adh_short (E-value: 5.4e-52, bitscore:
                     166.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-16, bitscore:
                     50.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GTHAARWMAEHGAEHLLLVSRSGDQAPGATQLAEELRTLGARVTF
                     AAADVADPDAMRTLLDTIPADTPLTAVLHTAGAPGGDPLDATGPEDIARILGAKTSGAQ
                     VLDELLQGTPLDAFVLYSSNAGVWGSGGQGVYAAANAHLDALAARRRARGETATSVAWG
                     LWAGDGMGRGADDAYWQRRGIRPMSPDRALDELAKAVCHDETFVAVADVDWERFAPAFT
                     VSRPSLLIDGVPEARQALAAGAAAPGDASSASGQSSALAAITALPEPERLPALLTLVRT
                     HAAAVLGHPSPDRVAPGRAFTELGFDSLTAVQLRNQLSAAVGAKLPATTVFDHPTPTAL
                     AAYLHQEYVAPADPAPTDWEGRVRRALSELPLDRLRDAGLLDAVLRLTGIEPEPAPGGP
                     AGDTAGADGEPEAEPAASIDDLDAEALIRMALGPRTT"
     gene            complement(22953..>24265)
                     /locus_tag="ASC82_RS04415"
                     /old_locus_tag="ASC82_29085"
     aSDomain        complement(22965..23183)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04415_PKS_Docking_Cterm.
                     1"
                     /evalue="4.40E-11"
                     /label="ASC82_RS04415_PKS_Docking_Cterm.1"
                     /locus_tag="ASC82_RS04415"
                     /protein_end="432"
                     /protein_start="359"
                     /score="35.5"
                     /tool="antismash"
                     /translation="EGRVRRALSELPLDRLRDAGLLDAVLRLTGIEPEPAPGGPAGDTA
                     GADGEPEAEPAASIDDLDAEALIRMALG"
     aSDomain        complement(23220..23435)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04415_ACP.1"
                     /evalue="1.10E-32"
                     /label="ASC82_RS04415_ACP.1"
                     /locus_tag="ASC82_RS04415"
                     /protein_end="347"
                     /protein_start="275"
                     /score="104.1"
                     /tool="antismash"
                     /translation="LTLVRTHAAAVLGHPSPDRVAPGRAFTELGFDSLTAVQLRNQLSA
                     AVGAKLPATTVFDHPTPTALAAYLHQE"
     aSModule        complement(23220..>24259)
                     /domains="nrpspksdomains_ASC82_RS04415_PKS_KR.1"
                     /domains="nrpspksdomains_ASC82_RS04415_ACP.1"
                     /incomplete
                     /locus_tags="ASC82_RS04415"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(23763..>24259)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS04415_PKS_KR.1"
                     /evalue="1.40E-49"
                     /label="ASC82_RS04415_PKS_KR.1"
                     /locus_tag="ASC82_RS04415"
                     /protein_end="166"
                     /protein_start="0"
                     /score="160.4"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GTHAARWMAEHGAEHLLLVSRSGDQAPGATQLAEELRTLGARVTF
                     AAADVADPDAMRTLLDTIPADTPLTAVLHTAGAPGGDPLDATGPEDIARILGAKTSGAQ
                     VLDELLQGTPLDAFVLYSSNAGVWGSGGQGVYAAANAHLDALAARRRARGETATSVAWG
                     LWA"
     CDS_motif       complement(23808..23918)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04415_0002"
                     /evalue="9.40E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="ASC82_RS04415"
                     /protein_end="151"
                     /protein_start="114"
                     /score="50.3"
                     /tool="antismash"
                     /translation="LDAFVLYSSNAGVWGSGGQGVYAAANAHLDALAARRR"
     CDS_motif       complement(24195..>24259)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS04415_0001"
                     /evalue="7.50E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASC82_RS04415"
                     /protein_end="22"
                     /protein_start="0"
                     /score="28.2"
                     /tool="antismash"
                     /translation="GTHAARWMAEHGAEHLLLVSRS"
ORIGIN
        1 cggcggcgtc gcggccaaca tcgcgtacgg cctcggcctg ctcggccgcc gccccgtcct
       61 cgtcggcgcc gtcggcaagg acttcgacgg gtacggcgag ctgctccgca ccgcgggcgt
      121 cgacaccggc gccgtacggg tgtcggagcg gcagcacacc gcccgcttca tgtgcaccac
      181 cgacgaggac ggcaaccagc tcgcctcgtt ctacgcggga gcgatggccg aggcgcgcga
      241 catcgacctg ggcgagacgg tcgggcggcc cggcgggccg gacctggtcc tcatcggtgc
      301 ggacgacccg gaggcgatgg tgcgccacac gcgggtctgc cgcgagctgg gcgtccgccg
      361 cgcggccgac ccctcgcagc agctcgcgcg gctggagggc gacagcgtcc gggagctcgt
      421 cgacggggcc gaactgctct tcacgaacgc gtacgagcgg gcactgctgc tgagcaagac
      481 cggctggacc gaggcggagg tgctcgaccg ggtcgggacg tggatcacca cgctcggcgc
      541 caaggggtgc cgcatcgaca cggccggccg gccgggcatc gagagcgcgg ccgtccccgc
      601 gacggacgcc gccgacccca ccggcggcgg cgacgccttc cgcgcgggct tcctcgcggc
      661 gctggcctcc ggcctcgagg tcgtcgacgc ggcccgggcg ggcgcggcca tggccacctt
      721 cgccctggag tcggtcggtc cgcagacgta cggggtcacg cgggaggggc tccatgagcg
      781 gctggtcgcc acgtacggcc ccgaggccgc ggtgatcacc cccgccctct tcgacggggc
      841 cctgtgaggg agccgacgga ggcgggccgg acgacgcagt ccggcccgcc cgtcggctac
      901 gccgagccgc cgtccggggc cgtcctgtac ggcgggtccg gtgccggggt cgtcctgtac
      961 ggcgagtccg gctccggcgc cggggccgtc gtgtgcgcgg agtccgcgga cgccgggtcc
     1021 gggcacaccg gatccgcgta cgccgggtcc gggaccgccc gggagtccaa cgcccgctac
     1081 aagcggctga tcgccgacgg cacgccgggg ctcacggtcg ccttcgacct gccgacccgg
     1141 atgggccgcg actcgcgctg accggcacga tccgcaacga cgtggcggag gagtgcgcgg
     1201 cgcgaaggag gccctcgcgg ccggcgccac cgtgggagag gtctgcgacg cgctccgcgc
     1261 ggcgtggggc ccggacgctc cgcaggcaac gccgctcggc gccgtgtgat ccgggcgccc
     1321 ccggggaggc agggcggtga acggccgccc ggcgtccccg gggcgcctca cgcggtgacg
     1381 gacttgtcct gggcgaggct gacggggagg tccgccctgc gggtcacgtt cagcttccgg
     1441 tacacgcgcg tcaggtgctg ctcgaccgtg ctcgcggtga cgcagagccg gcgcgctatc
     1501 tgacgattcg tcaatccccg ggcggcgagg gccgcgacgc gccgctccgc ctccgacagc
     1561 aggccgacgt ccggcccgcc cggcagttcc aggtcggggc tcacggcctt cgcccggcgg
     1621 ccgccacggc ccggcacgat ctcctcggcc agcgggtacg cgccgcaggc ccacgccatg
     1681 tcgccggcga gccgcgcggt catccgggcc cggtagttgt ccccctgcgc ctgctggtga
     1741 cggctcatcc cggccagcgc ccgcgcgtgc tccagccggt ccccgctgtc gtgcagcatg
     1801 tcgaccgcct cggcgtgcag ccgctccgcc tgctggccgt ccgcggccgc cgcgagcacc
     1861 cgcagggtga ggccgcgcgt acgggaccga ccgggccgca ccagggcgag ctgcgcctcg
     1921 gccagcgccc tggccttctg gcggttgccg agccgcagat agacctcggc ggccgaggtc
     1981 cgccacggca cgatcgacgg ctggtcgagg ttccagctgc ccaggatctc cccgcagagc
     2041 atgaactcgc cgagcgccgc gtgcagccgt cccgtcgcca gccagtaacg gccccgggcg
     2101 tgcatgtact ccatgccgtg ccgcgagtcg aacatcgcgt ccggcaccgg ctgccgcagg
     2161 acccgctccg cctgctcgta ctcgccggcc tccgtgcagg cgaggagcag cgcggacagg
     2221 ggcacgccca ccgcgaggcc ccagctctcc ggcgccgcgt gcgagagcgc cagctcggcc
     2281 cgctcccggg ccgtcgggag gtccccgcag cggaccgcga tcatcgcccg ggtcgcggcg
     2341 aagaccgcct cccagccgag cgagcggcgc tccgaggcct cggcgagcag cgcgtccgac
     2401 cagaacagcg cccggtcgag ccggtcggcg tggacgagca cgagcagggc cgtctccagc
     2461 gcctcgtacg tgtcctccga caggcggcag ccctgcagta tctgctcggc ctgtgcgacc
     2521 gaggcgttgt ccgggccccg ctggaagacg cccgcctggg cctggagcgc ggtcgtccgg
     2581 ggcgcgagcc gcaccgggac gggaccccgc tccggctcgg gcgcatccgg gagcgactcc
     2641 aggagcggag ggcacagcgc cgccagccac atgcgggtca gcgacagttc caggttctcg
     2701 ctgtcggtgc cgggccgcag ccgggacagc gcgtcggcgg cctcgggcag ccgcccgtac
     2761 cagacgaggc agcggatcag tgccatgacc gggtggctgg gcggcagttc gccgcccagg
     2821 agccggtcga agagcgcgag cgcccgggtc gtcatgtgcg ggttcatccg ccaggacgcc
     2881 gcgaccaggt gcggggcgag gcgggccagc tgcgtgttgt cggtgctgga gcgcacggcg
     2941 aattcgagga tccggaacgc gtcgtcgaga cggtcgtcga acagggcctg ctgcgcgccc
     3001 cgttcgagca gcggcagcgc ccagggggcg tccggggcgc cgccgacgag gaggtgacgg
     3061 gcgacggtgt cctcgtcggc gccgtcgcgg tgcagctgct cggcggcgcg ccggtgcagt
     3121 tcggtgcggt ccgcggccgg caggtcctgg agggcggcct cgcgtatcgc gggatgcccg
     3181 agcgtgccgt cctcgccgag gaggccgatc gcgccgagct ccaggaggtg gcgctcgacg
     3241 gcggtggccg tcgcgccggt gagccgctcc accaggagcg gatcggcctg ttcgaggacg
     3301 gcgagccagc gggccgtctc cagggtgccc tcggtgctgc ggtgcagaca gtcgaggacg
     3361 gcctgggcga aggcgtcgcc gtgcacgggg tcgtcgccgc cggccccgcc gagggtggtg
     3421 cgggccgcct gccggtcctg ggtcagcgcc cggaggagca gcgggttccc gccggtcgcc
     3481 gcgtggtacg cgggagctcg ccgctcggcc gcctcggggc cgtagtggtg ggcgaggaac
     3541 cggcgtacac cgctcggggg cagaccggcc agccacatgc tgcggcaatg cggctggcgg
     3601 agcagctcgg cgcggaacac ccggtacccg gcgcgctgcg aggcgcgctc ggtgaggacg
     3661 aagccgatgc ccccctggtc ggggtgggcg gcacagtgca ggatgaacct cagggacgcg
     3721 gtgtcggcgt gggtcaggtc gtcgacggcg atgaggaacg gggtgccgcg ggcgacggac
     3781 agcagccagt cgtgcagccg gtgcgtctcg tcgacgcgga gcggcgcgtc ggcgggagag
     3841 gtcaggttcc cggcccttcg cgaagccccg tcgaccaggt cgcggacggt ggacgtgtcg
     3901 gcaccgtgct gctcggcgct gcgcagcaac tggcagagca cgcccagcgg gacgtcgcgg
     3961 tcgcccggca gcgcccggac cgtccacacg ggcgtccccc gctcggccgc caggcggcgg
     4021 agcgaccgca gcagctccgt cttcccgctg ccggccggcc cggagacgag taagagcgtc
     4081 ccgtcgcctg cggcggatgc gtcaagaacg gcacccagat gggctatctc cccgtcgcgt
     4141 tccaccagat tcatcgcgga agtccccctc gtccgggcac cgaacttttc ggccgcccgc
     4201 cgatcactct aaccagctcc tgttacggcg aaagggcacc gaaccgggcg ccgggcgtgc
     4261 gaccgcccgg cctcggggga cgcgcgggtt cagccggtgc gcccgcccgc ttcgcgccct
     4321 cggcgccagc ggaccggcag ggccttgagc ccgcggatca tcgggttcgg gtaccagacg
     4381 agctcgccgg gggagacgtc cagggcgagg tccgggcagc gttcgaggag ggcgcggacg
     4441 gcgatccggg cctccatccg ggccagtggg gcgcccaggc agaagtggat gccgtggccg
     4501 aacgcgaggt gcccgctcgt gtcccggcgg atgtcgaagc ggtgcgggtc ggggaagcgc
     4561 tccggcgtgc ggtgggcgtc ggcgaggacg acgaggacct tgtcgccggc cggaatgacc
     4621 gttccgtcca ggtcgacggg ttcgaccggg aaacggtagg tcgccgattc caccggtcct
     4681 tcgtagcgca gcatctcttc cacggcaccg tccaagagcg tcatgtcggc gcgcagggcg
     4741 gacagctggt cggggtgcga gaggagcgcg tacatgccgt tggtgatcag attgaccgtc
     4801 gtctcatggc ccgcgaccag caggatgtgc gccatcccga gcagctcctc gggggtcagc
     4861 cgcgagccgt cctcgtcgct ggtccgcacg agcgcgctga gcaggtcctc gccctgcacg
     4921 ccgcgcttgg agtcgatcag ccgggacagg tagcggctca tctcggccat cgccgtctgg
     4981 gcctcggcgg ggtcgtcggg gaagacgaag gcgtcggtcc agacgcggaa ggccgcgcgc
     5041 tccggctcgg gcacgccgag gagttcggag atcacggtga tcggcagcgg ccaggccagg
     5101 gcctccatca ggtcggcgcg cccgtcgggg gccgccagca tggcgtccat gaggccgtcg
     5161 acgatctcct ggacgcgggg gcgcagcaac tcgacgcgac gcatggtgaa ctcacgggcc
     5221 accagcttgc gcagccgggt gtgccgcggc gggtcggact ccagcatgtt ctggttgacc
     5281 tgggtctccg cctcggtcag caccgtcgag gagttgcgcc agtccttgct gaaccgaggg
     5341 tcggtgagga ccgcccgcgc ctgctcgtag ccgacgacca gccacacctc gtccccgtcg
     5401 ggggtgcgca cccgatgggc cgggccttcg gcgcggagtc tggcgtacgt cggatagggg
     5461 tcggccgcga agtccttccc cagggcggcc agatcgagta ccgggggcga cgccgtcgtg
     5521 ccctcgtggg tgcgcacgga gaactcctga ctgggaaccg gaagcggaac ggaaacggga
     5581 agaggaacgg gacttctcgc gcgtactctt ccgcggagcg cgccccggtc ctcccgacgg
     5641 ctccgctgat tcccggatcc tgtcaagcat catcacattc ggaccgccga tggaataccc
     5701 cggaagcaga tgtgatccga agcacatcct cggtgtggca atgtgctctt gtcggtccgt
     5761 tgcgcgcgga ttagagtccc cccgaaatcg accaccacaa tcgaccatct cgtcgtacgt
     5821 cacggtggag cgcggcgacc tcgttcggga ttcccggatc ggcgaatcat ttcgtgacgg
     5881 tggcccggag ggaacatccg tgaaaagcgc cttatccgac ctcgcattct tcggcggccc
     5941 cgccgctttc gaccagccgc tcctcgtggg gcggcccaac cgcatcgacc gcgccaagct
     6001 ctacgagcgg ctcgaccggg ccctcgacgg ccagtggctg tccaacggcg gtccgctcgt
     6061 ccgcgagttc gaggagcgcg tcgccgacct cgccggcgtc cggcacgccg tggccgtctg
     6121 caacgccacc gccgggctcc agctcctggc ccacgccgcc ggcctgaccg gcgaagtgat
     6181 catgccgtcg atgacgttcg ccgccacccc gcacgcgatg cgctggatcg gcctcacccc
     6241 ggtcttcgtc gacatcgacc cggacaccgg caacctcgac ccggagcagg tcgccgccgc
     6301 cgtcaccccc cgcacctccg ccgtcgtcgg cgtccacctg tggggccgcc cctgcgccgc
     6361 cgaccagctg cggaaggtcg ccgacgagca cggcctgcgg ctgttcttcg acgccgccca
     6421 cgccctcggc tgcgcgatcg acggccggcc cgcgggcagc ctcggcgacg ccgaggtctt
     6481 cagcttccac gccaccaagg ccgtcaacgc cttcgagggc ggggccatcg tcaccggcga
     6541 cgccgacctc gccgaccgga tgcgcgccct ccacaacttc ggcttcggcc tgcccggcgg
     6601 cagccccgcc ggcggcacga acgccaagat gagcgaggcc aacgccgcca tgggcctcac
     6661 ctccctcgac gcgttccccg aggtcatcgc caggaaccgg gccaaccacg ccgcctaccg
     6721 cacgcagctg gaaggcatcc ccggcgtcct cgtcgccgac cacgaccggc acggcgtcaa
     6781 caaccaccag tacgtgatcg tcgagatcga cgaggagatc accggcatcc accgcgacct
     6841 ggtgatggac gtcctgaagg ccgaagggat ccacacccgc gcctacttct ccccgggctg
     6901 ccaccagctg gagccgtacc gcgggcagcc gcacgccccg ctgccgcaca ccgaacgcct
     6961 cgccgagcgc gtgctctccc tgccgaccgg caccgccgtc gacgaggacg acatccgccg
     7021 cgtcggcgac gtgctgcggt tctgcgcgac ccggggccac gagctgaccg cgcgccaccg
     7081 cgacccggcg gacgccgccg tcgccccccg ggcggccagg ccgtgaagcc cgccgtcgcc
     7141 ccccggacca ccacgcccac gcccacgatt ggacgctcct gatgaccgcc cctgcccccg
     7201 ccgccaccgc cccggccgaa cgctgcgcgc accccggagc cgacctgggg gcggcggccc
     7261 acgccgtcgg ccagaccctc gtcgccggcg gcctcgtccc gtccgacgag gccggaacca
     7321 ccgcccggca cctcgtccgg ctcgccgtcc gctacggcaa cagccccttc accccgctcg
     7381 aagaggcccg ccgggacctg ggcgtcgacc gggacgcctt ccgccgcctc ctcgccctgt
     7441 tcgggcagct gccggagctc cgcgtcgccg tcgagaccgg ccccgcgggg gcgtactgga
     7501 agaacaccct gctgcccctg gagcagcgcg gcgtcttcga cgcggccctc gccggcaagc
     7561 ccgtcttccc gtacagcgtc ggcctctacc ccggcccgac ctgcatgttc cgctgccact
     7621 tctgcgtccg cgtgaccggt gcccgctacg acccgtccgc cctcgactcc ggcaacgcga
     7681 tgttccgctc ggtcatcgac gagatcccca cgggcaaccc gttcgccctg tacttctccg
     7741 gcggcctgga gcccctcacc aaccccggcc tcggcaccct ggccgcgcac gccgtccagc
     7801 acggcctgcg gcccaccgtc tacacgaact ccttcgcgct caccgagcgc accctggagc
     7861 gccagcccgg cctgtgggac ctgcacgccg tccgcacctc gctctacggc ctcaacgacg
     7921 aggagtacga gcagaccacc ggcaagaagg ccgcccacac ccgcgtccgc gagaacctgc
     7981 gccgcttcca gaaggcacgg gccgaacgcg agtcgccgat caacctcggc ttcgcctaca
     8041 tcgtgctccc gggccgcgcc tcgcgcctgc tcgaccttgt cgacttcatc gccgacctca
     8101 acgaggcagg tcagggccgg acgatcgact tcgtcaacat ccgcgaggac tacagcggcc
     8161 gcgacgacgg caagctgccc cagcaggagc gggccgagct ccaggaggcc ctcgccgcct
     8221 tcgaagcgcg ggtcaacgag cgcacccccg gcctccacat cgactacggc tacgccctga
     8281 acagcctgcg ggccggcgcc gacgccgaac tcctgcggat caagcccgaa accatgcggc
     8341 ccaccgcgca cccgcaggtc gccgtgcagg tcgacctcct cggcgacgtg tacctgtacc
     8401 gcgaggccgg cttccccgac ctggacggcg ccacccggta catcgcgggc cgcgtgaccc
     8461 ccgacacctc cctcaccgag gtcgtcaggg acttcgtcga gcgccgcggc caggtggagg
     8521 cccgcgacgg cgacgagtac ttcatggacg gcttcgacca ggtcgtcacc gcccgcctga
     8581 accagctgga gcgggacgcg gcggacggct gggaagacgt ccgcggcttc ctgcgctgat
     8641 ccccacccgc acgctctccc cttccgaggg cccggccgtc cggccgggcc ctcggcgttt
     8701 tccccacccc ccgaaggagg agacggcact ccccctgcac agcccctagc gcccccctat
     8761 ctaggtaccg ccaaccgtta ttgccgacgc tctcctgcta gcttccggga atgaagggaa
     8821 tagtcctggc cggcgggagc ggaactcgac tgcatccggc gacctcggtg atttcgaaac
     8881 agattcttcc ggtctacaac aaaccgatga tctactatcc gctgtcggtt ctcatgctcg
     8941 gcggtattcg cgagatacaa atcatctcca ccccccagca catcgaactc ttccagtcgc
     9001 tgctcggaga cggcagccat ctgggaatcg aactcgacta tgcggtccag aaagagcccg
     9061 cgggaatcgc ggacgcactt ctcgtcggcg ccggccacat cggcgacgac agctgcgccc
     9121 tgatcctggg cgacaacatc ttccacgggc ccggcctcta cacgctcctg cgggacagca
     9181 tcgcgcggct cgacggctgc gtgctcttcg gctaccccgt caaggacccc gagcggtacg
     9241 gcgtcgccga ggtggacgcc gagggccggc tgaccggcct cgtcgagaag ccggagaagc
     9301 cgcgctccaa cctcgccgtc accggcctct acctctacga caacgacgtc gtcgacatcg
     9361 ccaagaacat ccggccctcg gcccgcggcg agctggagat caccgacgtc aaccgcgtct
     9421 acatggagcg cggccgggcc gaactcgtcg acctgggccg cggcttcgcc tggctggaca
     9481 ccggcaccca cgactcgctc ctccgggccg cccagtacgt ccaggtcctg gaggagcggc
     9541 agggcgtctg gatcgccggc cttgaggaga tcgccttccg gatgggcttc atcgacgccg
     9601 aggcctgtca cggcctgggg gaacgcctct cccgcaccga gtacggcacg tacctgatgg
     9661 agatcgccgg ccgcgaggga accccgtgag gggaacgacc cctcgcggcc ttcgcgtgcc
     9721 cgcgaccgac cgcgtgaccc acagcgccac cgtcagctcc gtcagctccg tcagctccga
     9781 cagcaccgac agcgcgaccc accgcgcgac cgaaaggaag acaccgtgcg gcttctggtg
     9841 accggaggtg cgggcttcat cggctcgcac ttcgtgcggc aactcctcgc cggggcgtac
     9901 cccgacgtac ccgccgacga ggtgatcgtc ctggacagcc tcacctacgc gggcaaccgc
     9961 gccaacctgg cccccgtgga cggcgacccg cggctgcgct tcgtccacgg cgacatccgc
    10021 gacgccggcc tcctcgcccg cgagctgccc ggcgtggacg ccatcgtcca cttcgcggcc
    10081 gagagccacg tggaccgctc catcgcgggc gcgtccgtct tcaccgagac caacgtgcag
    10141 ggcacccaga ccctcctcca gtgcgccgtc gacgccggtg tcggccgggt cgtgcacgtc
    10201 tccaccgacg aggtgtacgg gtcgatcgac tccggctcct ggaccgagag cagcccgctg
    10261 gagcccaact ccccctacgc cgcgtcgaag gccggctccg acctcgtcgc ccgcgcctac
    10321 caccgcacgt acggcctcga cgtccgcatc acccgctgct gcaacaacta cgggccctac
    10381 cagcaccccg agaagctgat ccccctcttc gtgaccaacc tcctcgacgg agggaccctg
    10441 ccgctgtacg gcgacggtgc gaacgtccgc gagtgggtgc acaccgacga ccactgccgc
    10501 ggcatcgcgc tcgtcctcgc gggcggccgg gccggcgaga tctaccacat cggcggcggc
    10561 ctggagctga ccaaccgcga actcaccggc atcctcctgg actcgctcgg cgccgactgg
    10621 tcgtccgtcc gcaaggtcgc cgaccgcaag ggccacgacc tccgctactc cctcgacggc
    10681 gggaagatcg agcgcgagct cggctaccgg ccgcaggtcg cgttcgccga cggcctcgcg
    10741 cgcaccgtgc gctggtaccg cgagaaccgc gactggtggg agcccctgaa gacccccgcc
    10801 cccgagctgc ccgccgcgac cgcgggggtg cccgcgtgac cacccgcgta cccacccccc
    10861 gcgtcccctt cctcgacctc aaggccgcct acgacgagct gcgcgccgag accgacgccg
    10921 cgatcgcccg cgtcctcgac tccggccgct acctcctcgg acccgaactg gaaggcttcg
    10981 agaacgagtt cgccgcctac tgcgagacgg accacgccgt cggcgtgaac agcggcatgg
    11041 acgccctcca gctcgcgctc cgcggcctcg gcatcggacc cggcgacgag gtgatcgtcc
    11101 cctcgcacac gtacatcgcc agctggctcg ccgtgaccgc gaccggcgcg acacccgtgc
    11161 ccgtggagcc gcgcgaggac caccccaccc tggacccgct gctcgtcgag aaggcgatca
    11221 ccccccgcac caaggcgctc ctccccgtcc acctctacgg acacccggcc gacatggacg
    11281 ccctccgcga cctggcggcc cggcacgacc tgcacatcgt ggaggacgcc gcgcaggcgc
    11341 acggcgcccg ctaccggggc cggcgcatcg gctccggatc gtccgtggcc gccttcagct
    11401 tctacccggg caaaaacctc ggctgcttcg gcgacggcgg cgccgtcgtc accggcgacc
    11461 ccgagctcgc cgaacggctg cggatgctcc gcaactacgg ctcccggcag aagtacagcc
    11521 acgagatgaa gggcaccaac tcccggctgg acgagatgca ggcggccgtc ctgcggatcc
    11581 gcctcgccca cctcgacgcc tggaacggcc gcaggtcggc gctggccgcc gagtacctct
    11641 ccgggctcgc cggactcccc ggcatcgccc tgccggtcac cgcacccgac accgaccccg
    11701 tctggcacct cttcaccgtg cgcaccgagc gccgcgacga gctgcgggac cacctcgacg
    11761 cccgcggcat cgacacgctc acgcactatc cggtgccggt ccacctctcc gccgcctacg
    11821 cgggcgacgc cctgcccgcc ggccccctgc cggagggctc gctgccccgc gccgagagct
    11881 tcgcacggca ggtcctcagt ctgccgatcg gcccgcacct ggagcgcgca caggcgctgc
    11941 gggtcgtcga ggccgtgcgc gaatgggccg tgaacgccgg ctgatccggc cgtacacagc
    12001 ccgaaaaggc ggtgcccgcc accctcccgg gtggcgggca ccgccgtctt cacggcgtca
    12061 cgtcaccaga cgttgaccgt cgcactgccg cgcaggtcgg cggaggacga accggtctgc
    12121 agaagacggt tgcccgtccc cgtcttccag cagtccgccg cggcgtccca gaactgcagc
    12181 tgacggcggt cgacgttgat cgtcaccgtc ttcgactcgc ccgcggcgag cgacaccttc
    12241 gtgtagccca cgagcttctt cttcgcctgc ggggccgtca cgttcgggct ggcaccgagg
    12301 tacgcctgga cgacctcctg gcccgcgcgc tgcccgctgt tgcggaccgt gaccgtgacc
    12361 ttcaggccgc ccgtggtcgt ccgcacgacg gtcggggcgc tctgcgtgaa cgaggtgtac
    12421 gacaggccgt gcccgaacgg gaacagcggc ttgacgttct ccttgtcgaa ccagcggtac
    12481 ccgacgtgga tgccctcggt gtactgctgc tggttgtcga cgcccgggta gcggttcggg
    12541 tcgcctgcga cggcgtgctg gttctcggcg gccgggaagc tctgcgtgag cttgccgctc
    12601 gggttgacgt caccgtagag cagcgaggcg gtggcctcgg cacccgcctg gcccgggtac
    12661 cacatgtcca ggaccgcacg ggtcttggac agccacggca tcagcaccga cgaaccggtg
    12721 ttgaggacca cgatcgtgtt cgggttggcg tcggcgaccg ccgagatcag cttgtcctgc
    12781 gtacccggca gcgacaggtt cggacggtcg acgccctcgg tgccgtcgtc gtaggcgaac
    12841 acgatggccg tacgggcctt cttcgccgac tccacggcct tcgcgatcgt cgcgtcggcc
    12901 gcctgcggcg tcacccagcc cagctccagg gagagcgggg tggcgctcat cgcgaagccc
    12961 gagatggtga gcttgtgcgt gcccttggtg agcttgagga gcgggctgct caccttgccg
    13021 tagacctggc cggcctcgat ggtgtggctg ccgagctgca ccgtggcgta accaccggtg
    13081 gcgcggaccg cgatccggta ctcgccgtcg gcgggcacgg tcagcgtgcc gtcgtacagc
    13141 gccccggcct gacccggctg gagctgcacg ccctggttga acgccgggct gaggttcgcc
    13201 gccgggatct gcgtcccgaa ggtctcctca cccgtctcgt acgtcaccgt cgcaccggcg
    13261 cccgcgcggg ccttgatggt gtcgagcgga gccgccgccg agtccgggac gacgtgggcg
    13321 ctgcccaggc cggtgacctt ggggtcgacg gccgtcgggc cgatgaccgc gatgctcttg
    13381 ccggcgtcac cggcgagcgg cagggcctgg ccctcgttgc gcaggagcac cgcgccgttc
    13441 tcggcgacct tgcgggagac cgcctgggcg cccgccttgt cgcgctcggg ccgcggcgcc
    13501 ggggtggcga ggagcagacc gaacttgtcc atctggttga cgatgcgctc cgccgactgc
    13561 gtcacggccg actcggggat cgtgccgttc aggacggccg tcttcagcgc gtcgccgaag
    13621 aacttggccg gcggcgaggg ctcgcccggc gggatgtcgc cgggaagctc gacgcccatc
    13681 tcctggtcga ggcccttggt gatggcgtcg gtgcccgggg tggcgagcca gtcggacatc
    13741 acccagccct ggaagcccca ctgcgtgcgc agcacgttgt tgaggagctc gtcgttgccg
    13801 caggacggct tcccgttgag gccgttgtag gcacacatga aggaggccgc gccggccttg
    13861 gaggacgcct cgaacgccgg gaactcgatc tcgcggagcg tctgctcgtc gaccgtggcg
    13921 ttcacgctga agcggttgtt ctcctggttg ttggccgcga agtgcttggc cgtggtcatc
    13981 agacccgcac cctggatgcc cttgatctgg gcgaccgcgg tgcgcgagga gaccaggggg
    14041 tcctcgctga aggtctcgta gttccggccg ccgtgcggca cccggatgtt gttcatcatc
    14101 gggcccagga ccatgtcctg gcccagcgcg cgaccgtcgc ggcccatgac cttgccgtag
    14161 ctgtcggcca tggtgtcgtc gaaggtgctg gccagggcga ccggcgcggg cagcgcggtg
    14221 gccgtcttgc ccaccaggcg gatgccgttc gggccgtcgg cggcacgcag ctccgggatg
    14281 ccgagacgcg gcacgcccgg gaggtagccg acgttctgac ggtcggggtc caacgcccag
    14341 tggacgaagc tgatcttctc gtccagcgtc atctgggcga cgagctccgc cgcccgggtc
    14401 gtgtactgga cgttcgccgc cccggcggtg ccgggggcgg ccgccgcgac ggtggtgccc
    14461 gcgaggagag tgccgacgac ggccagggtg aaggccctgg ggctcgtacg gccgcgcctg
    14521 acacgcggta ttcgagactt acctgtcact gttcgtttct ctctctgtac ttggtgcacc
    14581 cgggggttcg tcccggggag tctgtggggg gtcggctctg gtccaggacc tagggcctgt
    14641 ccggccctga tccgccggac aggccctagg cgggcacgcc gacgaagagg ccgcggcccg
    14701 acggcccgcc ctccaggtac tcgacgcgca gcccggcggc cgtgaacgcg gcctcgtact
    14761 gggcctggtg gaagagcgtg atgaggtgga cgtcggagaa gtgccgcacg cccttgcccg
    14821 ggtcggccac cgtgaagtgg acctccatgc gcgtcgcgtc gccctcccgc accgagtgcg
    14881 agacgcgggc cacggtgcgc ccgtcccggc ggacgacgtc cgcgctcacc cagccgtcgg
    14941 cgaaggtctc cgggaaccac cacggctcga cgacgacgac gccgccgggc tccaggtgct
    15001 ccgcgaacga ggcgacggcc gcgtcgagtt cgtcggtcgt acgcaggtag ccgaccgagc
    15061 tgaacatgct gacgacggcg gagaacctac ggccgagccg gaagtcccgc atgtcgccct
    15121 ggtggagcgt ggcgtcgggc agccgcgtgc gggcgtggtt cagcatgtcc tcggacagct
    15181 ccaggccggc cgtgtcgccg aactccttgg tgaagtgctc caggtgcgtg cccgtgccac
    15241 aggccacgtc gaggagcgag gacgcctcgg gcgtacggga gcgcaccagg tcggcgatgt
    15301 cggaggcctc ggcggcgtag tccttgccgc gaccgagata gaacaggtcg tagacgtcgg
    15361 cgtggtcgac ttcgtaggac acggaactcc tgctttcggt gggccggggg cgtgccccgg
    15421 acgggtcgga gggacggctc agggacgggc gtcggccggc gggcggcggt gctgggcggc
    15481 cagccgctcc agctcgggga cgattcccgc gggggtgggg tcgcgatacg tctcgtcgcg
    15541 cagccggtgc gcggcggtcg tgaccgaggg gtcgtcgagg atgcggacga cggcgtcccg
    15601 gacggcctgc ggggtgagct cggccggcgg caggaagaac cccgccccct gctccgcgac
    15661 cgcccgcgcc ttgaccgggg cgtcccacag ctcggcgagc atgacctgcg gcaccgcgtt
    15721 gatcacggcc gtcgcgtagg tgcccgcacc gccgtggtgg atgatcgccg agcagctcgg
    15781 cagcagcgcg tgcatcggca cgaagtccgt gaaccgcgtg tgcttcgggt agttgcggat
    15841 ctcggcgcgc tgactcgcgt cgagcgtggc gatcagctcg atgtcgaggt cggcgagcgc
    15901 ctccaggatg tcgccctggg agacgccgtc accgccgagg acctcacgcg cggagacgcc
    15961 gagggtgagg cacacccggg gccgcgccgg cggctcgctc agccagtccg gcacgaccga
    16021 cgtgccgttg tacggaacgt agcgcatgcc gacggtcggc agaccggtgt cgagccgcag
    16081 gctcggcggc gtcgggtcga cggtgaactg accggtgatc agctcctcct cgaaggaggc
    16141 gccgtaccgg tcgagcgtcc acgtcagcca ctccgcggtg gggtcctccc ggtgctcggg
    16201 cggctgccgg tcccgcagcg cgacgaactt ccggcgggcg ctgcccatca cgtccggccc
    16261 ccacaggacc cgggcgtgcg cggcgccggt gacctgcgcg gcgacggcgc ccgcgtaggt
    16321 cgtcggctcc cacaggacca ggtccggctg ccaggaacgg gcgaagtcga ccaggtcgtc
    16381 gaccatcgag tcgttgttgg cgagcaggta gaagtacggg gcgaggatcg cctcgatgcc
    16441 gagggcgtgg tcccagtcca gcggctccgt acgggcctcg tcgaaggcga tcgccgggtg
    16501 gttcggccgc ggctcgcccg ccatccgcac ccggtactcg tggatgaggt ggtcggtgcc
    16561 gacgggcact gcggcgagcc cggacccggt gatggtgtcc gtgagcgcgg gctggctggc
    16621 gacccgcacc tcgtggccgg cggcgagcag ggcccaggcc aggggcacga ggccgtagta
    16681 gtgcgtgtga tgtgcgaacg aggtcagcag gacgcgcatg gcgtcgttgt ccttcctgcc
    16741 ggtggagggg cggggcgggg tggggcgggc gcgggggacc gcgcccgccc ggtgtctcag
    16801 gcgctcaccg ggacgctcag cggcccgcgg ccgacgggag cgcgacgggg gtggagcacg
    16861 ggcccggcct gccgcagccc cgggaagcgg cccgccaggg tccgcagcgc gacctccgcc
    16921 tgcagcctga ccagggacgc caccgggccg tacggacctg cggggtgcag cgcgaggtgc
    16981 gcggcggcgt cggggcgcgc gaggtcgaag cgctccgggt ccgcgaagac ctccgggtcc
    17041 cggccggccg cggcggtgag gacgacgaca tgggcgccga ccggcagccg ccggcccgcc
    17101 aactcggtct ccgtacgcac cacccgggcg tccagctgca cgggcgggtc gtagcggagg
    17161 gtctcctcca ccgcggccgg cgcgagcccg ggccgctcgc acagctcctt ccactgcccg
    17221 gggtgggcga ggagggccag cacggcgttg ccggtgagcc ggacggcggc ggagaccccg
    17281 agcgccgaca gcagagcgcc gtccggccgg agtgacccgg ccggggcatc ggcagcggcg
    17341 tcggccgagg agtcggcagc ggagtcggcg agcaggaccg tgagcgcggc cagcgcgtcg
    17401 tcggccgccc gtaccgtccg cagtgactgc ggggccagca ggctgtccga cagcggccgg
    17461 agctgctcca cgagcgcgcc gaactccgcc cgccggtccg aggggacacc cagcacggcg
    17521 gccgtcgcgg ccgtcaccgc cggacggacg aacccgccca ccagctcgaa cgcgtacgac
    17581 gccgacgggt ccggaaccag gccctccagg gtctcccggt gaacccgctc caccaccgca
    17641 cggtcaccgg actccgccgc cccgcgcgcc gccggcagcc cccgctcgtg ctccaacggg
    17701 cagccctccc cgtacgagag gacctgctgc gccacgggcc cgccgtccgc gccggacacc
    17761 ccgaagtccg cggacgacag gacgctcgcc gccagggcgt gcccggagac gacccagctg
    17821 cccgtcggac tgaaggacag cggaccgcgg gcccgcagcc gctcgtactc gggatacggg
    17881 tcgtccgact ggccgcgcag cacggccgcg tacgggtcgc cgttcgcggc gtggatccag
    17941 tggatgccgc gggtctccag gaggtgggtg ccgagttcgc gatcggccac cgcgcggacg
    18001 gtacggccca gcgggggctg cgtgagcgcc cccgtcaggt cgtcgctcac cgtgggttct
    18061 gccatctctt cgccgctcct tcgataagac tggtcggggg ctgcacgaca cgcggatcgg
    18121 gtgcgcagcg ggtgacgagc aggtggtcgg agatgtcgtt gcagatctcg tgccactggt
    18181 cgttgaggta gaagtggccg cccgagtagg cgcgcaggca gaacggcccg ttggtgtgcc
    18241 gacgccactc ggccacctcg ttcagcggcg ccttcggatc ccggtcgccg gccagggcca
    18301 tcaccgggca ggcgagcttg gcggacggcc ggtgctcgta cgtctccgcg gccttgtagt
    18361 cgctgcgcag cgcgggcagc accatccgca tcagctcgtc gtcctggagg aaccggtcgt
    18421 cggtgccgct caggcgccgg atctcggcca ggaaggcccg gtcgtccagc tggtggacga
    18481 gcccggccgg cgcgagcgac ggcgcgcgcc gcccggagac gtacaggccc tcgggcttca
    18541 ccccgtgccg ctgctccagg atccgggccg cctcgtaggc gacggaggct ccgaggctgt
    18601 gcccgaagaa ggcgagaccg ccctcctgcc accagcgttc cgtcgccgcg accacgtgct
    18661 cggcgagctc ctcgacgctc tccaggcacg gctccgcgcg ccggtcctgc cgccccgggt
    18721 actgcaccga caacgcttcg acggaggggt gcagctcctc ggagaaacgg aagaagtagc
    18781 tggcggaacc gcccgcgtgc ggcaggcaga ccagccgcac cgtgctgtgc ggcgacgggt
    18841 ggaaacgccg gatccacagg ctgctgtcca cgttcaggga tctgtcgctc actggtccgc
    18901 cccctgcgcc gtgccccgct cgacggcgtc gagccaggag atgacggcgt cggcgacggc
    18961 gggcgcgtgg tcccgcatca tcgtgaagtg atcgccgggc acgtccacga cggtgtgcgg
    19021 aaggtcccag tgggcacgcc agtcaccgcg ctcctccgac cactcgccca gcggctcgga
    19081 ggcacgcacg aggaggacgg gcgcgctgct gcgacccggc cgcgcgtcgg cgaggaaccg
    19141 ggcgtaccgg cccatggcca gcagccgcga gtcggccatc ggctccagct cgccggcgaa
    19201 cagaccctcg ccgagctgcc tgctccacgc ctcgacgggc tcctgatggc ccggcggata
    19261 ggggtcgacc aggacgatcc cggcgggcgg ggcgccatgg gcccggtcca ggcggaaggc
    19321 gagctcgtgg gcgagcaggg cgccgccgga gtgcccgacc aggaccaccg gggcgtcccc
    19381 ggcggcccgg aggagcgcca gggcctgggc gtcgagcgcg gtgtcgaggt cggcggggag
    19441 gagcgcggtg ccggtacccg taccggtgcc gtagccgggc agcggcaggg cgaggaagtc
    19501 ccgctcctcc tggaaggagg cgctgagccg caggaactcc tgcgggccgc cgttcgccgc
    19561 ggtgccggtg cagccgacga gcagggtacg gccgcccgct cggtccgccg gcgcgccggc
    19621 gagcagcacc gggtcgagcc gctccgcaca atcctcgggc gtggcgaact gcggtcggaa
    19681 cgacgaggct tcggcgagga cgccgaggaa ctcggagtac cggccgtctt ccacggcctg
    19741 ccggaacagg gcgcggaaca tgccgccgtc tgcgccgggg gtggcgccgg gggagcggcg
    19801 cggggcggtg gtggactggg gggtggtcgg ggcggtgggt cgctcttccg tacggggttc
    19861 ggcgacggcc cagccccgct cggccagctc gccgctgacg cggtcggcca gcgcggcggg
    19921 cgtggggtgc tcgaagacgg cggtggcggg gagctggagc ccggccagcc ggttgatgcg
    19981 gttacggagc tcgacggccg tcagcgagtc gaagccgagc tcccgcaggg gccggtcggc
    20041 ggggagctcg tcgggcgtgt cgtgcccgag cgcggcggcc gcctgccgca gcaccatggc
    20101 gaggacgacg ccgcgccgcc cttcctcgtc gagatcggcg acgtcgagac cccacgccgg
    20161 tccggcctcg gcctcggtct cgctctcggg agcggtgtgc gtgggcgctt caccgggggc
    20221 cgaggggttg atccagtagg ggcggtgctg gaaggcgtag gtggggaggt cggcgtgggt
    20281 ggtcgaggaa gggaggtggg aagtccagtc gacggggagg ccgttggccc aggcttcggc
    20341 cagggaggtg atgagccggg tctgtccgcc ctggtcgcgg cggagggtgc cgagtccggt
    20401 gacggtctcg gggagggcca tggtgaggac ggggtgggcg ctgacttcga tgaagtgggt
    20461 gaagccttcg tcgggcggag gttgcggtac cagtaggcgc cgtccagagc cgcctcggtg
    20521 atccaggagc cttcgagcgt ggagaagaac gggacccgcg gagcctgcgg ggtcagcccg
    20581 gcgaggacct tggcgaggtc ttcctcgatg atctcgacgt gggcgctgtg ggaggcgtag
    20641 tcgacgggga tgatccgcgc gcggacgccg tcggcctcgc aggcgtcggc gagttcctgg
    20701 atctgggcgg gatcgccggc gacgacggtg acggtcgggc cgttgacggc cgcgaccgac
    20761 aggctgtcga ggttctcgat ccgctgctgg gtggcctcct cgctgagagc gagggagatc
    20821 atgccgccct tgccggcgag gtgcgcggcg atggactggc tgcgcagagc cacgacgcgg
    20881 gcggcgtcgt cgagggtcag ggccccggcg acgtaggcgg cggcgatctc gccctgggag
    20941 tggccgatga cggcctgcgg cgtcacgccg tagtgctgcc acacgcgggc gagggagacc
    21001 atgacggcga aggtgacggg ctggacgacg tcgacccgct ccagtgaggg cgcacccggc
    21061 gtctgccgga cgacggcctc aagggaccag tcgacgtacg gggagagtgc ggtctcgcac
    21121 tcggccatgg cttccgcgaa ctccttcgat acgtcgagga gttcggctcc catcccggcc
    21181 cactgcgtgc cctggcccgg gaacacgaag gccacccgtc cgaggtcgga cgccgtgccg
    21241 cgtaccagcc cctccggcat ccgcagggcg tcccgcaaag cctcccggct gtcgccgacc
    21301 gcgaccgcgc ggtactccat cgccgtgcgc ccgtcgagca gcgtacgagc cgccacggcc
    21361 ggacccaggt ccgtacggct gtccgcgtac gcggcgagcc gtccgatctg ggcgtcgagc
    21421 gcggcggggg tcttcgcgga gacgagccac ggcacgacac cggccgggga ctcgacggcc
    21481 cgcgccgcct cggtggtcgg ggcctcctca aggaccacgt gcgcgttcgt gccgccgacg
    21541 ccgaacgccg agacgcccgc ccgccgcggg cggcccggct gcgccggcca gtccacggcc
    21601 tcggtgagca gctcgacctc gcccgccgtc cagtcgacct ggtccgtcgg ctcgtccacg
    21661 tgcagcgtct tcggcagcac gccgtggcgc atcgcctgca ccatcttgat gacgcccgcg
    21721 agccccgaag cggcctgcgt gtggccgatg ttggacttca ccgtgcccag gcgcagcggc
    21781 tgtcccggcg aacgcccctg cccgtacgtg gcgagcagag cctgtgcctc gatcgggtcg
    21841 ccgagccggg tccccgtgcc gtggccctcc acgacgtcca cgtcccgcga cgtgagccgc
    21901 gcgtcggcga gggcctgccg gatcagccgc tgctgcgagg ggccgtgcgg ggccgtgagc
    21961 ccgttgctcg caccgtcctg gttgatggcg ctgccgcgca ccacggccag cacccggtgt
    22021 cccttgcgcc gcgcgtcgga gaggcgctcg accaggagca cggcgacgcc ctcgccccag
    22081 gcgaggccgt ccgccgccga ggcgaacccc ttggtccggc cgtccgcggc catggcctgc
    22141 tgccggctga actcgatgaa cgcccccggc gtcgcgagga ccgccacacc gcctacgagg
    22201 gccgtcgagc agtcgccgtt ccgcaggccc ttcagggcca ggtgcagggc gacgagcgag
    22261 gaggagcagg ccgtgtccac ggtcacggcg ggcccctcaa gaccgaggga gtacgcgatg
    22321 cgccccgagg ccacggcgga ggagttgccg gtgacgacgt agccgccggt gccctcgggc
    22381 gcgacccgga tgtccggcgc gtagtcctgg tagccgcagc ccacgtacac gccgacgtcc
    22441 gtgccgcgca ccgacgcggg gtcgatgccg gcccgctcga agacctccca ggaggcttcg
    22501 aggagctgcc gctgctgcgg gtccatggcg agggcctcgc ggggcgagat cccgaagaac
    22561 cccgcgtcga agccggcggc gtcgtcgagg aacgcggcgt tgcggacgta cgtcgtgccc
    22621 ttccgcccgg gctccgggtc gtagagggat tcgatgtccc agccgcgttc ctcgggcacg
    22681 tcggagacga ggtccttgcc cgcggcgacg gcgtcccaga ggtcctcggg ggacccgata
    22741 ccgccggcga agcgacagct catgccgacg atcgccatgg gctcctgccg acggtcgtcc
    22801 tggcggcggc tctctttgcg gagttcttcg ttctccttga gagaggcgcg cagagcgtcc
    22861 accaactgct cgttggaact cgtcatctgg gtgtggtctt ccgctcgtgg atggggttgt
    22921 gggtgtgtgg ggggcgtgtg accggaccgc ggtcaggtgg tgcgggggcc cagagccata
    22981 cggatcaggg cctcggcgtc gaggtcgtcg atcgaagccg ccggctccgc ctccggctct
    23041 ccgtcggcac cggcggtgtc gccggccggg ccgccgggcg ccggctcggg ctcgatgccc
    23101 gtgaggcgca ggacggcgtc gaggagaccc gcgtcgcgca gccggtcgag gggcagctcg
    23161 gacagcgccc ggcgcaccct cccctcccag tcggtggggg cggggtccgc cggtgcgacg
    23221 tactcctggt ggaggtacgc ggcgagcgcg gtgggcgtcg ggtggtcgaa gaccgtggtg
    23281 gcggggagct tggcgccgac cgccgccgag agctggttgc gcagctgcac ggccgtgagc
    23341 gagtcgaagc cgagctcggt gaaggcgcgg cccggggcca cccggtcggg ggaggggtgg
    23401 ccgagtacgg ccgccgcgtg ggtgcggacg agcgtgagga gcgcgggcag gcgctccggc
    23461 tcggggagcg cggtgatcgc ggccagcgcc gacgactgcc cggacgccga ggaggcgtcg
    23521 ccgggggccg cggcgccggc ggcgagcgcc tgccgcgcct ccgggacgcc gtcgatcagg
    23581 aggctgggac gggagaccgt gaacgcgggc gcgaacctct cccagtccac gtcggcgacg
    23641 gcgacgaagg tctcgtcgtg gcacacggcc ttggccagct cgtccagggc gcggtccggg
    23701 ctcatcgggc ggatgccgcg ccgctgccag tacgcgtcgt cggcgccccg gcccatgccg
    23761 tcgcccgccc agaggcccca ggcgaccgag gtcgcggtct cgccgcgggc ccggcgcctg
    23821 gcggcgagcg cgtcgaggtg ggcgttggcc gccgcgtaga cgccctggcc gccgctgccc
    23881 cacaccccgg cgttggagga gtagaggacg aaggcgtcca gcggagtgcc ctgcagcagc
    23941 tcgtcgagga cctgggcgcc gctggtcttc gcccccagga tgcgggcgat gtcctcgggg
    24001 ccggtggcgt ccagcgggtc gccgcccggc gcgccggcgg tgtggaggac ggcggtgagg
    24061 ggggtgtcgg cggggatggt gtcgaggagg gtgcgcatgg cgtcggggtc ggcgacgtca
    24121 gcggcggcga aggtgacgcg cgccccgagc gtgcggagct cttcggcgag ttgggtggct
    24181 ccgggggctt ggtcgccgct gcggctgacg aggaggaggt gttcggcgcc gtgttctgcc
    24241 atccatcggg ctgcgtgggt gccga
//
