LOCUS       NZ_LMEI01000001        21635 bp    DNA     linear   CON 26-MAY-2024
DEFINITION  Streptomyces sp. Root431 contig_1, whole genome shotgun sequence.
ACCESSION   NZ_LMEI01000001
VERSION     NZ_LMEI01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root431
  ORGANISM  Streptomyces sp. Root431
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 876078)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 876078)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140605
            Assembly Name                     :: Root431
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426585.1-RS_2024_05_26
            Annotation Date                   :: 05/26/2024 02:21:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,904
            CDSs (total)                      :: 5,829
            Genes (coding)                    :: 5,744
            CDSs (with protein)               :: 5,744
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 22 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 1 of 85
            Pseudo Genes (multiple problems)  :: 10 of 85
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:56:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 237432
            Orig. end                         :: 259067
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEI01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21635
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21635
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21635
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11635](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11635
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(647..4348)
                     /locus_tag="ASC82_RS01105"
                     /old_locus_tag="ASC82_01105"
     CDS             complement(647..4348)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033436.1"
                     /locus_tag="ASC82_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01105"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_056640093.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.1e-55, bitscore:
                     184.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRITPFARGRAGLLAAGVSLVMLSAGQTAAAGNTASAVPDTFK
                     ASATSSTVTLVTGDRVTLTDLGGGKQTVTVDRAKGATGAIRSQIANGRVTVIPDEARPY
                     LASGALDPRLFDVTGLVEQGVTGELPLIVTYGAKGARAAASTPRGAETVRPLPSIGGAA
                     VTATDPAAFWQGFTAQQAATTPNARAAAPAKVWLDGRVEAAMAESNAQIGTPKAWEAGL
                     TGKGVKVAVLDTGADLAHPDLGGRVAETRSFIEGQEVADRNGHGTHVASTVGGSGAGSD
                     GKEKGVAPGATLAVGKVLSDEGSGSESQIIAGMEWAAKDIDAKVVSMSLGSREPSDGTD
                     PMAQAVNTLTAETGALFVIAAGNSGYPGSIGSPGAADSALTVGAVDSADEAAYFTSQGP
                     RYGDQALKPDLSAPGVDILAARSQLVAGSGLYTSMSGTSMATPHIAGVAALLAEKHPDW
                     TGAQLKNALMSSSKTLDASAYALGAGRVDVAAAISANVTATGSADLGFVSWPYEESEPV
                     TRTVTYTNASDAPVELNLAVEGMPAGVAALADTTLTVPAHGSASTTVTGDGTKAPVGQS
                     SGRITATAGGAPVAHTALGLVKEEERYTLTVHVKDRDGAPTAAHLGVQQLTKDVDPFPA
                     AVGESGTLELRLKPGTYTVDTFLDVRGSHGKDSLGLGFLTAPEITLDRDREITLDGRQL
                     REIRAEVEKRTETRQLLMEFDREANGASYGGAVQVPPMYDSIFAAPTAKPATGTFEYRT
                     VWRLGKPLLEASVDGTRLSGATPQAGGTLLEGGHRLGLVDAGTGTPAEYTGKNVTGKAV
                     LVRLTAGADPTELAQTAQDAGAKALFVTDDQPGRLMKWFGTADYEDRPLAVATVNTADA
                     QRLAAGAARGKRVELTGTRFTPFTYDLSEGHPGAIGKDLVFRPDEDELATISSTFYAPT
                     KRKELGGEFRYSITDTFPVGFGFKEWISFPTERTEYVSTGTGQRWHESVDLGDSLEERG
                     GTPSYKGGSRVDLDWFGPVWHPWLGTGLGWGQQRSGNDLRFNTPGWGDSGTDHTGFGNV
                     WGDDSMTQFTEVYVDGVRVDRKMSSGAYAWDAPAQEATYKVVTDTALDPARWRLATKGR
                     SEWTFRSAETPADKATYLPMLNLGFDVDTDLDGDVRAGSKLPVRTFAEYVKGAAGTGTI
                     TGGTLDVSYDEGKTWTKVALKPSWRGASWSGELRIPSGAASVSLRAGASDDQGGTVTQE
                     LIRALGVK"
     misc_feature    4426..4439
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            complement(4515..5777)
                     /locus_tag="ASC82_RS01110"
                     /old_locus_tag="ASC82_01110"
     CDS             complement(4515..5777)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239164.1"
                     /locus_tag="ASC82_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01110"
                     /product="MFS transporter"
                     /protein_id="WP_056640096.1"
                     /transl_table=11
                     /translation="MTTTEKPQDETTRRRVFADLTPLRTSADYRRLWFGSTVSWVGQGM
                     TALAVSLQVYEITRSPFSVGLVGLFSLVPLVVFGLYGGAVADTVDRRKLGLASALGSAV
                     LSIALAGAAFAGFHRVWFLYGIVALQSVCAALNSPARTSMIPRLLPPEQLRAANALNSM
                     VMTFGTLVGPSLGGLIVGVAGYQTAYLVDALAFSASLYAMWRLPSMLPDRKGSKRASVL
                     DGLRFLATRPNLRMTFFSDFCAMILAHPRALFPAVAVLWYGGDAKTAGLLVAAPAFGAL
                     LGGVLSGWQGRIRHHGQAILIAVACWGTAIAVFGLTRNLWLGLLLLALAGYSDTVSMIF
                     RNTMMQVAAPDEMRGRLQGVFIVVVAGGPRLGDFLAGSVADLTSPAVAITGGGIACVLA
                     VGLLALYGRRFRRYDALDPTP"
     gene            complement(5774..6220)
                     /locus_tag="ASC82_RS01115"
                     /old_locus_tag="ASC82_01115"
     CDS             complement(5774..6220)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239165.1"
                     /locus_tag="ASC82_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01115"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_056640099.1"
                     /transl_table=11
                     /translation="MPDITIRRATADDSKRLTRLVRTSAAYRGDYAAMVEGYQVGGAYI
                     EHHPVFVAVDENDRVLGFYALLLGEAELDLAFVADSAQGLGIGRLLMEHMTAQARAAGL
                     AAVRVVAHPPAEEFYLRTGAVRTGVLPPAGRIHWARPELRYDVA"
     gene            6432..6578
                     /locus_tag="ASC82_RS29810"
     CDS             6432..6578
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASC82_RS29810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_199862447.1"
                     /transl_table=11
                     /translation="MAKAASPAAHESLGAALSLTDERLIAQAREAFTTALHSTSALARP
                     SPW"
     gene            complement(6689..7945)
                     /locus_tag="ASC82_RS01125"
                     /old_locus_tag="ASC82_01125"
     CDS             complement(6689..7945)
                     /GO_function="GO:0004144 - diacylglycerol O-acyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0045017 - glycerolipid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Condensation_Starter (14-139). E-value:
                     2.3e-07. Score: 22.4. Matches aSDomain:
                     nrpspksdomains_ASC82_RS01125_Condensation_Starter.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014998.4"
                     /locus_tag="ASC82_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01125"
                     /product="wax ester/triacylglycerol synthase
                     domain-containing protein"
                     /protein_id="WP_056640105.1"
                     /transl_table=11
                     /translation="MLDRLSLDVAALHATDSALHLGGLVTLEGEPPSRGRLLEHLRARI
                     ARIPELAHRLAGRTGRPHWEPDPRFDPERHLYELPGSTDPAAVLAELLRQPLPRDRPLW
                     GLWLVHRVGGGYGLCYRAHHAFQDGAAAVATLERLLGPEEAPRPRALSFRPPRPVPWAA
                     VLPELRPPRRVTWWPALDAPPSQAYATTVADVDTARLHALGRLTGATVPQLCLALTTEA
                     LRAWHPDAWKPGRPGHGHDLRTNLAIGVRDPDDPLPLLGNRVAVAGIDLPCGDPDPRRR
                     LDRVGRALDYTRLARLADAHRVILRRLPYRVGRLALTRSIDARYTPVGVADLRIRRPLG
                     FDGVPASGVYALPVMVPGQPLFVAWVTHRRRLHVTFTTDTALAAADRLPEAWHAALAEL
                     EQRAEEGEFARGAAAAGAR"
     aSDomain        complement(7529..7903)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS01125_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="2.30E-07"
                     /label="ASC82_RS01125_Condensation_Starter.1"
                     /locus_tag="ASC82_RS01125"
                     /protein_end="139"
                     /protein_start="14"
                     /score="22.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHAFQDG"
                     /tool="antismash"
                     /translation="TDSALHLGGLVTLEGEPPSRGRLLEHLRARIARIPELAHRLAGRT
                     GRPHWEPDPRFDPERHLYELPGSTDPAAVLAELLRQPLPRDRPLWGLWLVHRVGGGYGL
                     CYRAHHAFQDGAAAVATLERL"
     gene            8078..9463
                     /locus_tag="ASC82_RS01130"
                     /old_locus_tag="ASC82_01130"
     CDS             8078..9463
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172800.1"
                     /locus_tag="ASC82_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01130"
                     /product="cytochrome P450"
                     /protein_id="WP_242427507.1"
                     /sec_met_domain="p450 (E-value: 3.5e-48, bitscore: 160.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDGMHPDVPDVPKLPDFLDDAAVAAWSASGAPLVDLLRQAHTPG
                     RLTGFRRGGRAAVLVTDPRHVHQVLGVGGDRYVKRSHRARPLIGDGMLTATGEAWRSQR
                     RLLQAMFTGRGIQRWEHHIAAAADRVVGRWAERARRGEPTDIAEDVQFFTVDTIWRSLT
                     DRPLDQETYVDLAAVQDIVAALPADVGGGAALPPEVETALAALDERMHRAIAEARGRRT
                     ADGAPDGDAPGDGAPGGGAPGDGTPRDGASGGGASGSGPSVLDRLLGAAETDPAYTDRL
                     IRDELVTLLVAGYESSARTLTWAFVLLDRHPEVMERAAGDARAVEAVLSETLRLYPTGW
                     LLPRQAVADETLDGLRIPAGTDLLVCPYLTHRDPEVWPDPEAFVPERFPVRTPLPPGAY
                     LPFGIGPRACLGTRFAMREMEVLLGGLLARFTVETTEPVGEPVFGINLRPAGPLYARVR
                     ERT"
     gene            9460..9960
                     /locus_tag="ASC82_RS01135"
                     /old_locus_tag="ASC82_01135"
     CDS             9460..9960
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033443.1"
                     /locus_tag="ASC82_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01135"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_056640111.1"
                     /transl_table=11
                     /translation="MNAQPHERVDYVDPGDRVVAQGGRATGTPSGLLRRYAATVCTDHA
                     GRVLLYRRTATAPAYPDHYDVLVGGAVRAGEEYRAAALRELREELGWAAAPGLAEAYRI
                     RVDDPHGDCFLTVHRWVADRAPRPDPAEIAWCGFVTPLSILTGGYTPLVPAGAEAVRRL
                     FPL"
     gene            10001..11635
                     /locus_tag="ASC82_RS01140"
                     /old_locus_tag="ASC82_01140"
     CDS             10001..11635
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239168.1"
                     /locus_tag="ASC82_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01140"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_107105789.1"
                     /sec_met_domain="T2TS (E-value: 3.1e-63, bitscore: 209.6,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSCALPLRGVSLAVPGALPGSVPPTDPGRPGLDRARARLATRL
                     VAAAGPDGLLRAPCDGRILESALALRLLTVTGVDPDAQERLTRYLKITLDEGDPDPVQE
                     AAARAALGEYVDGRAALNRLLGGFDHFTAGRKRLMFRTVLAELGAHPFPELASGEPDFE
                     ARGQQRWLVTEMAALKTLYAFGTGVPHLVTEDDWRALAPCSLPGPPPYGNHLARILALL
                     ALRHRPGYAAAVRARARELRTWLRADGGLPFITGMDVFATATGGLALAGAGVPAHTLRA
                     LAAALAERQNPDGGWGFDRGVGQSDVDDTAYCVEFLRASAPELSGPAVAAGERYLLDRQ
                     GGDGGFPTFEHGTASEVAITAAAVNALAPEPGHRPAVEAAVRFVVARQEDAGAFERSWS
                     LNESNALFRSVLAYDSFRAVAPPGHALEAGVARARARAVDRLVGTQNADGGWGHVPADP
                     SDPISTAYALIAVCRGRDGPSVPCGPSARGAAERAVRHLLERQRADGGFVSRPDQAGPR
                     PLAYHVPLLTDICVLLGLNHARAPHPL"
     misc_feature    10025..10027
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11661..11891
                     /locus_tag="ASC82_RS01145"
                     /old_locus_tag="ASC82_01145"
     CDS             11661..11891
                     /NRPS_PKS="Domain: PP-binding (12-68). E-value: 3.9e-15.
                     Score: 47.9. Matches aSDomain:
                     nrpspksdomains_ASC82_RS01145_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146311.1"
                     /locus_tag="ASC82_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01145"
                     /product="acyl carrier protein"
                     /protein_id="WP_024758253.1"
                     /sec_met_domain="PP-binding (E-value: 8.6e-14, bitscore:
                     47.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDELKNLLVSLGLDPAEITPESTREEAGLDSLLLTELALVLRK
                     ERGIPVPEEELYAAPTVAAIEGLVARYAAVA"
     aSDomain        11697..11864
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS01145_PP-binding.1"
                     /evalue="3.90E-15"
                     /label="ASC82_RS01145_PP-binding.1"
                     /locus_tag="ASC82_RS01145"
                     /protein_end="68"
                     /protein_start="12"
                     /score="47.9"
                     /tool="antismash"
                     /translation="LGLDPAEITPESTREEAGLDSLLLTELALVLRKERGIPVPEEELY
                     AAPTVAAIEGL"
     gene            11891..13126
                     /locus_tag="ASC82_RS01150"
                     /old_locus_tag="ASC82_01150"
     CDS             11891..13126
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (76-409). E-value:
                     2.1e-59. Score: 193.5. Matches aSDomain:
                     nrpspksdomains_ASC82_RS01150_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467648.1"
                     /locus_tag="ASC82_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01150"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_056640114.1"
                     /sec_met_domain="t2fas (E-value: 2e-117, bitscore: 387.9,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.4e-49, bitscore:
                     163.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGGRPARPGAAVTGVGLFTPAGADRATTWETVRVGKPTAGLEEL
                     DGIRYLACRAPELPDGPGGLGRAAVARRPDRSAALALVAAREALADAGLDAGTWDGMRV
                     GVVAGTGAGGTLTYERQLAVVREDGPGDMSPFAVPGALPNAVAAQLAVEFGIRGPSMAV
                     TTACASGATAIGVALDLLALGRCDVVLAGGSDASLSSFYIAGFDRLRALSHRFHDPSGG
                     LRPFDVDRDGFVMAEGAGFLVLERPADAAARGARTRALIGGYGATSDAHHVVAPRPDGS
                     GLAAAVREALAEAGAAPGDVDLVNAHGTGTPRGDAVEAAVLARLLPHGPPVTSTKGVTG
                     HLLGAAGAVEAALTVLSVAEDTVPPTANFTEPGEGVDLDVPTVARSSRVRLAVSTSVGF
                     GGHNAALVITAP"
     aSDomain        12119..13117
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC82_RS01150_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.10E-59"
                     /label="ASC82_RS01150_PKS_KS.1"
                     /locus_tag="ASC82_RS01150"
                     /protein_end="409"
                     /protein_start="76"
                     /score="193.5"
                     /tool="antismash"
                     /translation="SAALALVAAREALADAGLDAGTWDGMRVGVVAGTGAGGTLTYERQ
                     LAVVREDGPGDMSPFAVPGALPNAVAAQLAVEFGIRGPSMAVTTACASGATAIGVALDL
                     LALGRCDVVLAGGSDASLSSFYIAGFDRLRALSHRFHDPSGGLRPFDVDRDGFVMAEGA
                     GFLVLERPADAAARGARTRALIGGYGATSDAHHVVAPRPDGSGLAAAVREALAEAGAAP
                     GDVDLVNAHGTGTPRGDAVEAAVLARLLPHGPPVTSTKGVTGHLLGAAGAVEAALTVLS
                     VAEDTVPPTANFTEPGEGVDLDVPTVARSSRVRLAVSTSVGFGGHNAALVIT"
     CDS_motif       12362..12409
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS01150_0001"
                     /evalue="2.60E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="ASC82_RS01150"
                     /protein_end="173"
                     /protein_start="157"
                     /score="13.5"
                     /tool="antismash"
                     /translation="GPSMAVTTACASGATA"
     CDS_motif       12800..12844
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC82_RS01150_0002"
                     /evalue="3.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ASC82_RS01150"
                     /protein_end="318"
                     /protein_start="303"
                     /score="10.2"
                     /tool="antismash"
                     /translation="VNAHGTGTPRGDAVE"
     gene            complement(13133..13615)
                     /locus_tag="ASC82_RS01155"
                     /old_locus_tag="ASC82_01155"
     CDS             complement(13133..13615)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239169.1"
                     /locus_tag="ASC82_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01155"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_056640118.1"
                     /transl_table=11
                     /translation="METLDTVPDEDFLRLDHQICFSLHAATRAFNGVYREALKELGITY
                     PQYLVMLVLWEHGELPVKGIGERLRLDSGTLSPLLKRLEAAGYVERRRSPEDERSVTVR
                     PTGDGTALKEKALGVPRRIAAATGLSLEDIRDLRERLDALAVRLDAVDPDALSSCT"
     gene            13744..14160
                     /locus_tag="ASC82_RS01160"
                     /old_locus_tag="ASC82_01160"
     CDS             13744..14160
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606625.1"
                     /locus_tag="ASC82_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01160"
                     /product="organic hydroperoxide resistance protein"
                     /protein_id="WP_056640121.1"
                     /transl_table=11
                     /translation="MDAIYTAVATANGREGRAVSSDGHIDLPLAHPQALGGNGLGTNPE
                     QLFAAGYAACFASAMGVVARQEKIDIADASVTAEVSIGKDPADGGFGLAVIMRAEFPDH
                     LQGEAGVTLLEKTHAFCPYSKATRGNIQVELVVE"
     misc_feature    complement(14209..14220)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            14392..16452
                     /locus_tag="ASC82_RS01165"
                     /old_locus_tag="ASC82_01165"
     CDS             14392..16452
                     /GO_function="GO:0004629 - phospholipase C activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239178.1"
                     /locus_tag="ASC82_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01165"
                     /product="phospholipase C, phosphocholine-specific"
                     /protein_id="WP_056640123.1"
                     /transl_table=11
                     /translation="MADLNRRRFLQLTGGAAALTMLSESIARAAAIPAQGSTGTIQDIE
                     HIVVLMQENRSFDHYFGAMKGVRGFGDPRPVTLPSGKSVWNQEDNSGKVTLPFRPTSDK
                     LGMEYLQGLNHDWQGGQSAWNKGKYNNWIPAKTKATMAHLTREDIPFHYALADAFTICD
                     AYHCSFIGATDPNRYYMWTGYVGNDGTGGGPVLNNAEAGYGWTTYPERLETAGVSWKIY
                     QDIGDGLNAAGSWGWIGDAFRGNYGDNSLLYFNNYRNAQPGNPLYDKARTGTNAKAGEG
                     YFDKLRADVQAGNLPQISWIAAPEAFSEHANWPANYGAWYIAQVLDALTSNPDVWARTA
                     LFITYDENDGFFDHVVPPYVPADASWGKSTTPTAQDWFPGKIGYAAGPYGLGPRVPMIV
                     VSPWSKGGYTCSETFDHTSVIRFMESRFGVREPNISPWRRAICGDLTSAFDFTRTDTQP
                     APLPPTAGYYPPDKNRHPDFLATAPAVGTMPRQEPGTKPTRPLKYAPYVDGAADTTAGT
                     FRLTFSGGPAAGAQFYVTSANRTDAPWTYTTEANKSLSDTWNTKYSKTLTDLTVHGPNG
                     FLRHFRSPGKTAVPEVTARHNATTGNLDLTLTNATAAAVTLTITNTYAGTPQTVTVPKG
                     GTATHTVSLSASARWYDVTVTTPSQTDFLRRLAGHVETGAPSTTDPGILTY"
     misc_feature    complement(14393..14407)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
     gene            16652..17107
                     /locus_tag="ASC82_RS01170"
                     /old_locus_tag="ASC82_01170"
     CDS             16652..17107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125537.1"
                     /locus_tag="ASC82_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01170"
                     /product="hypothetical protein"
                     /protein_id="WP_056640127.1"
                     /transl_table=11
                     /translation="MSQQAPTGGQGNTGRAPGNAHRSGGGGGLAGGGTVFAAVLLSLSG
                     ILAVLQGITAIAKDDVYTRVGNYVFEFDLTAWGWIHLILGIVVVLTAVGLFMGSNWARA
                     AGICLAGLSMIANFMWLPYQPWWALTILAIDVFVIWALCTSWTHTPE"
     gene            17140..17466
                     /locus_tag="ASC82_RS01175"
                     /old_locus_tag="ASC82_01175"
     CDS             17140..17466
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019074214.1"
                     /locus_tag="ASC82_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01175"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_056640130.1"
                     /transl_table=11
                     /translation="MSTASETPVLDTLAAMTIDSIERCGLAPDMLMVARIAALAASDAP
                     PISYAAHIEMAIETGMTAEQVQDVLVAIAPIVGTARVMTAAGNISAALGIAIAVADAEI
                     ETQG"
     gene            17571..19004
                     /locus_tag="ASC82_RS01180"
                     /old_locus_tag="ASC82_01180"
     CDS             17571..19004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157633.1"
                     /locus_tag="ASC82_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01180"
                     /product="DUF2252 domain-containing protein"
                     /protein_id="WP_056640133.1"
                     /transl_table=11
                     /translation="MPKNVTTAAMRAARHATPEERAALGKEARGRSPRSGHAEYRPSAD
                     RPDPLAILEAQSATRVPELVPIRYARMTESPFRFYRGAAAIMASDLAATPRSGLTAQLC
                     GDAHLLNFRLLASPERQLMFDINDFDETLPGPWEWDVKRLSASFVIAARANGFDDAERR
                     RIVRGTVRSYREAMIRLANMRDIDVWYAKIDADRLKALAADQLHKRGRKNLARAMAKAR
                     TRDSLQAFDKLTETVDGRPVIAADPPLLVPASDLMPDVERTALERQFRSLIDRYGSTLQ
                     SDRRTLLAEYRLADVARKVVGVGSVGTRCWIFLLLGRDDQDPLFLQAKEADTSVLAEHV
                     GASAYRNQGERVVSGQRLMQAASDIFLGWERVDGFDGKRRDFYVRQLRDWKGIAVPEQM
                     TPRVMEAFGEVCGVTLARAHARSGDRIAIAAYLGGGTSFDRALATFAEAYADQNERDHQ
                     ALVDAVRAGRLPAEELPAA"
     gene            complement(19047..19559)
                     /locus_tag="ASC82_RS01185"
                     /old_locus_tag="ASC82_01185"
     CDS             complement(19047..19559)
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133035.1"
                     /locus_tag="ASC82_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01185"
                     /product="potassium channel family protein"
                     /protein_id="WP_056641392.1"
                     /transl_table=11
                     /translation="MRSTLTLAAVLAAYYLLPLDSAFTAGTVVVLVLGVVLVALLLAWQ
                     VHTIMASARPGLRAIAGVATALPFFVLLFAATYYLLERSAPGSFTETMTRTDALYFTMT
                     VFSTVGFGDIAPRSEVARLLTTGQMTANFLLIGVAARFLLGAVQEGRRLRGIRVPGDED
                     GGPPPAR"
     gene            19835..20251
                     /locus_tag="ASC82_RS01190"
                     /old_locus_tag="ASC82_01190"
     CDS             19835..20251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033450.1"
                     /locus_tag="ASC82_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01190"
                     /product="SHOCT domain-containing protein"
                     /protein_id="WP_056640136.1"
                     /transl_table=11
                     /translation="MKDSMVTLAVDYPLLNMFWTMLMIFCWVLWFMLLFRIIGDIFRDD
                     ELGGWGKAGWTVFVILLPFLGVFVYLIARGRGMGERELKRVRQNEEEFRSYVRETAGTG
                     GGHAEELARLAELKDRGAITEDEFAQAKAKVLAS"
     gene            20273..20953
                     /locus_tag="ASC82_RS01195"
                     /old_locus_tag="ASC82_01195"
     CDS             20273..20953
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033451.1"
                     /locus_tag="ASC82_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASC82_01195"
                     /product="GAP family protein"
                     /protein_id="WP_056640139.1"
                     /transl_table=11
                     /translation="MILDLFLIGLAIALYPIPVMAFVLVVSAPRGVYKGLAFIIAWLAC
                     LVAVIAMVLLFTGGQPPAPRSPPSIAALAATLVIGLSLIAYSEHRRRRSRRTAAVSASH
                     EKRPKGSGRSLTSRMDQATGWSAAGLAVLLQPWGMVSAAAATVVKADLSQVASFLALFG
                     FCVLATAGLLAMELYMVFAPEKAQLSLVRLRGWLERHKDPAIVLICLVLGLWLVGRSLY
                     QLTG"
ORIGIN
        1 cggcctgcgc ctggtggacg aggacggctc cgtcctgagc ccgctcgacg gggagaccgt
       61 cggcgaggtg caggtccgcg gcccgaacct cttctccggc tatctgaacc ggccggacgc
      121 gacggcggcg gccttcgacg gcgactggtt ccgcaccggc gacatggcgg tccgcgaggc
      181 ggacggcgcg gtgcgtctgg tgggccgcaa ggcgaccgac ctcatcaaga gcggcggcta
      241 caagatcggg gcgggcgaga tcgagaacgc gctcctcgac caccccggca tcagggaggc
      301 cgccgtcacc ggagagccgg acccggacct cggcgagcgg atcgtggcct gggtggtggc
      361 ggaggacgcc tcggcgccgc cggcggaggc ggagctcgtc gaccacgtgg cggggctgct
      421 cgccccgcac aagcggcccc gggtcgtgcg ctatctcgac gcgctccccc gcaacgacat
      481 gggcaagatc ctcaagaagg cgctccccgc ggctcgttga acaggcgtga ggccgggccc
      541 ccggctcacc ggggcccggc ctcacgcgtc gaggggtggc gctcgcgggt gtccggcgga
      601 tcacggccgg acacccacgc gcgtcacttc acgccgagcg cgcggattac ttcacgccga
      661 gcgcgcggat cagctcctgc gtgaccgtgc cgccctggtc gtcgctcgcg cccgcccgca
      721 gcgagacgga ggccgccccg gacgggatcc gcagctcacc gctccaggag gcgccgcgcc
      781 acgagggctt gagggcgacc ttcgtccagg tcttgccctc gtcgtaggag acgtccaggg
      841 tgccgccggt gatcgtgccg gtgccggccg cgcccttcac gtactccgcg aaggtccgta
      901 cgggcagctt ggagccggcc cggacgtcgc cgtcgaggtc ggtgtccacg tcgaagccga
      961 ggttgagcat cggcaggtag gtggccttgt cggccggggt ctcggccgag cggaacgtcc
     1021 actcggagcg gcccttggtc gcgagccgcc agcgggccgg gtcgagcgcg gtgtcggtga
     1081 cgaccttgta ggtcgcctcc tgcgccgggg cgtcccaggc gtaggcgccg gagctcatct
     1141 tccggtcgac gcggacgccg tcgacgtaca cctcggtgaa ctgggtcatc gagtcgtcgc
     1201 cccacacgtt gccgaagccg gtgtggtcgg tgcccgagtc gccccagccg ggggtgttga
     1261 agcgcaggtc gttgccggac cgctgctggc cccagccgag gccggtgccg agccacgggt
     1321 gccagacggg gccgaaccag tcgaggtcga cgcggctgcc gcccttgtac gacggggtgc
     1381 cgccgcgctc ctccagggaa tcgccgaggt cgacggactc gtgccagcgc tggccggtgc
     1441 cggtggagac gtactcggtg cgctcggtcg ggaaggagat ccactccttg aagccgaagc
     1501 cgaccgggaa ggtgtcggtg atcgagtagc ggaactcgcc gcccagttcc ttgcgcttgg
     1561 tcggcgcgta gaaggtggag ctgatggtgg ccagttcgtc ctcgtcggga cggaagacca
     1621 ggtccttgcc gatggccccg gggtgcccct cggagaggtc gtacgtgaac ggggtgaagc
     1681 gggtgccggt cagctcgacg cgcttgccgc gggccgcgcc ggcggcgagc cgctgggcgt
     1741 cggcggtgtt gacggtggcg acggcgagcg gccggtcctc gtagtcggcg gtgccgaacc
     1801 acttcatcag gcggccgggc tggtcgtcgg tgacgaacag ggccttggcg cccgcgtcct
     1861 gggcggtctg tgcgagctcc gtcgggtcgg cgccggcggt cagccggacg aggacggcct
     1921 tgccggtgac gttcttgccg gtgtactcgg cgggggtgcc ggtgcccgcg tcgacgaggc
     1981 cgaggcggtg gccgccctcc aggagcgtgc cgccggcctg cggggtggcg ccggagagac
     2041 gggtgccgtc gacgctcgcc tcaaggagcg gcttgccgag gcgccagacg gtccggtact
     2101 cgaaggtgcc ggtggcgggc ttggcggtgg gcgccgcgaa gatcgagtcg tacatcggcg
     2161 ggacctggac ggcgccgccg taggaggcgc cgttcgcctc gcggtcgaac tccatgagga
     2221 gctgccgggt ctcggtgcgc ttctcgacct cggcgcggat ctcgcgcagc tgccgcccgt
     2281 cgagggtgat ctcgcggtcg cggtcgaggg tgatctccgg cgcggtgagg aagccgaggc
     2341 cgagggagtc cttgccatgg gagccgcgca cgtcgaggaa ggtgtcgacg gtgtacgtgc
     2401 cgggcttgag gcgcagttcg agggtgccgg actcgccgac cgcggccggg aaggggtcca
     2461 cgtccttcgt gagctgctgg acgcccaggt gcgcggcggt gggggcgccg tcgcggtcct
     2521 tgacgtggac ggtgagggtg tagcgctcct cctccttcac gaggccgagc gcggtgtgcg
     2581 cgacgggcgc gccgcccgcg gtggcggtga tccggccgga ggactggccg acgggggcct
     2641 tggtgccgtc gcccgtgacg gtggtgctcg cggagccgtg ggcggggacg gtgagggtgg
     2701 tgtcggcgag ggcggcgacc ccggccggca tgccctcgac ggcgaggttc agctcgacgg
     2761 gggcgtcgga ggcgttggtg tacgtgacgg tcctggtgac cggctcgctc tcctcgtacg
     2821 gccaggagac gaagccgagg tcggcggagc cggtggcggt gacgttcgcg gagatcgccg
     2881 cggccacgtc gacgcggccg gcgccgaggg cgtaggcgga ggcgtcgagc gtcttcgacg
     2941 aggacatcag ggcgttcttg agctgcgcgc cggtccagtc ggggtgcttc tcggcgagca
     3001 gcgcggcgac gcccgcgatg tgcggggtcg ccatcgacgt accgctcatg gaggtgtaga
     3061 ggccgctgcc ggcgacgagc tgggagcggg cggcgaggat gtccacgccg ggcgccgaca
     3121 ggtcgggctt gagggcctgg tcgccgtagc gggggccctg gctcgtgaag taggcggcct
     3181 cgtcggcgga gtcgacggcg ccgacggtga gcgcggagtc ggcggcgccg ggcgagccga
     3241 tggagccggg gtagccggag tttccggcgg cgatgacgaa gagggcgccg gtctcggcgg
     3301 tgagggtgtt gacggcctgg gccatcgggt cggtgccgtc gctgggttcg cgggagccga
     3361 ggctcatcga cacgaccttc gcgtcgatgt ccttggcggc ccactccatg ccggcgatga
     3421 tctgcgactc gctgccggag ccctcgtcgc tgaggacctt gccgacggcg agggtggcgc
     3481 cgggggcgac gcccttctcc ttgccgtcgg agcccgcgcc gctgccgccg acggtggagg
     3541 cgacgtgcgt gccgtggccg ttgcggtcgg cgacctcctg gccctcgatg aaggacctcg
     3601 tctcggcgac ccggccgccg aggtcggggt gggcgaggtc ggcgccggtg tcgaggacgg
     3661 cgaccttgac gcccttgccg gtgagcccgg cctcccaggc cttcggggtg ccgatctggg
     3721 cgttggactc ggccatggcg gcctcgaccc tgccgtcgag ccagaccttg gcgggggcgg
     3781 cggcgcgggc gttcggggtc gtcgcggcct gctgggcggt gaagccctgc cagaaggcgg
     3841 ccgggtcggt ggccgtgacg gcggcgccgc cgatgctggg cagcgggcgg acggtctcgg
     3901 cgccgcgcgg ggtggaggcg gctgcccggg cgcccttggc tccgtacgtg acgatcagcg
     3961 gcagttcgcc ggtgacgccc tgttcgacga ggccggtgac gtcgaagagg cgcgggtcga
     4021 gcgcgccgga ggccaggtag gggcgggcct cgtcggggat gacggtgacc cggccgttcg
     4081 cgatctggct gcgtatcgcg ccggtggcgc ccttggcccg gtcgacggtg acggtctgct
     4141 tgccgccgcc gaggtcggtg agggtgacgc ggtctccggt gacgagggtg acggtgctgc
     4201 tcgtcgcgga cgccttgaag gtgtccggca ctgcggaggc ggtgttcccg gcggcggcgg
     4261 tctgcccggc cgagagcatc acgagggaga caccggcggc gagcagcccg gccctccctc
     4321 tggcgaaggg ggtgatcctc gacgtcatcg acgaaactcc tcgcggaccc ggggtcgggg
     4381 gtgttttccg ggtgccgcga ggagtcttgg cctgtggggc gggagttgac cccgttcact
     4441 gctggcggtt atgtgccgtg gcggccaacc gccaggtcag gacggtggct tcggggtgaa
     4501 acccgcccgg agcctcacgg agtggggtcg agtgcgtcgt accggcggaa acggcgcccg
     4561 tagagggcca ggaggccgac ggcgaggaca caggcgatcc cgccgcccgt gatggcgacg
     4621 gccggggagg tcaggtcggc cacggagccc gcgaggaagt cgccgagccg gggcccgccg
     4681 gcgacgacca cgatgaagac gccctggagc cgaccgcgca tctcgtcggg cgcggcgacc
     4741 tgcatcatcg tgttccggaa gatcatcgag acggtgtcgg agtagccggc gagggcgagc
     4801 aggagcagcc ccagccagag gttccgggtc agcccgaaga cggcgatggc cgtgccccag
     4861 caggcgacgg cgatgaggat cgcctgcccg tggtggcgga tgcggccctg ccagccggac
     4921 aggacgccgc cgaggagcgc cccgaacgcg ggcgccgcga cgaggagtcc ggcggtcttc
     4981 gcgtccccgc cgtaccagag gacggcgacg gccgggaaca gcgcgcgggg gtgggcgagg
     5041 atcatcgcgc agaagtcgga gaagaacgtc atgcgcaggt tggggcgggt ggcgaggaag
     5101 cgcagcccgt cgaggacgga cgcccgcttg ctccccttcc ggtccgggag catcgacggc
     5161 agccgccaca tcgcgtagag gctcgcggag aaggcgaggg cgtcgacgag gtacgccgtc
     5221 tggtagccgg cgacgccgac gatcaggccg ccgaggctcg gcccgacgag cgtgccgaag
     5281 gtcatgacca tcgagttgag cgcgttggcg gcgcgcagct gctcgggcgg caggagccgg
     5341 ggaatcatcg aggtgcgggc gggcgagttg agcgcggcgc acacggactg gagcgcgacg
     5401 atcccgtaca ggaaccagac gcggtggaag ccggcgaacg cggcgcccgc gagggcgatc
     5461 gacaggacgg cggagccgag ggcgctggcg aggccgagct tgcggcggtc gacggtgtcg
     5521 gcgacggcgc cgccgtacag cccgaagacg acgagcggga cgagggagaa cagcccgacg
     5581 agcccgacgg agaagggcga gcgggtgatc tcgtacacct ggagggagac ggcgagggcg
     5641 gtcatgccct ggccgaccca ggagacggtg ctcccgaacc agaggcgacg gtagtcggcg
     5701 gaggtccgca gcggggtgag gtcggcgaag acccggcggc gggtggtttc gtcctgtggc
     5761 ttctcggtgg tggtcacgcg acgtcgtacc gcagctcggg gcgggcccag tggatccgtc
     5821 cggcgggcgg gaggacgccg gtcctgacgg cgccggtgcg caggtagaac tcttcggcgg
     5881 gcgggtgcgc gacgacccgc acggcggcga gtccggcggc cctggcctgc gcggtcatgt
     5941 gctccatgag cagccggccg atgccgaggc cctgggcgga gtcggcgacg aaggcgaggt
     6001 cgagctcggc ctcgccgagg aggagggcgt agaagccgag cacgcggtcg ttctcgtcga
     6061 cggcgacgaa gacggggtgg tgctcgatgt acgccccgcc gacctggtac ccctcgacca
     6121 tggcggcgta gtcgccccga taggcggcgg aggtccggac gagccgggtg agccgcttgg
     6181 agtcgtcggc ggtggcgcgc cggatggtga tgtcgggcat ggggcgagta tagggacgta
     6241 ggcggttgtt actccttaca gtttggtgaa cgtgcgggcg gggggctgcc tcggcgcgcg
     6301 tgacgctccc cgcttgcccg tcgctccccc gctcgcgtgt cgttcccccg cttccgtggt
     6361 gtcctcagcc tccgtgggcc gcctcgctca cggcggtggc gtgcgggagg ctcccgccgt
     6421 gggcgaaggc cgtggcgaag gcggcttcgc cggccgccca cgagagcctc ggcgcggcgc
     6481 tctccctgac cgacgagcgc ctgatcgccc aggcccggga ggcgttcacc acggccctgc
     6541 actcgacctc ggcgctagcg cggccttcgc cctggtgacg gcggtcgcgg tcctcgccct
     6601 cctgcggggc gtcccccgca catgagttcc cccgcagcag cacatgacgg gcccggccgg
     6661 tcggcatcag ccgctcggcc gggcccgttc agcgcgcccc cgccgcagcc gcgccccgcg
     6721 cgaactcgcc ttcctccgca cgctgttcga gctccgcgag ggccgcatgc caggcctcgg
     6781 gcagccggtc ggcggcggcg agggcggtgt cggtcgtgaa cgtgacgtgg aggcggcggc
     6841 ggtgcgtgac ccaggcgacg aagagcggct gccccgggac catgacgggc agggcgtaca
     6901 ccccggaggc ggggacgccg tcgaagccga ggggccgccg gatccgcagg tcggcgacgc
     6961 cgaccggggt gtaccgggcg tcgatgctgc gggtgagcgc caacctgccg acccggtaag
     7021 ggagtcggcg caggatcacg cggtgggcat cggccagccg ggcgagccgg gtgtagtcga
     7081 gcgcccgccc gacgcggtcg agccgtcggc gggggtcggg gtcgccgcag ggcaggtcga
     7141 tcccggcgac ggcgacgcgg ttgccgagga gcggcagggg gtcgtcgggg tcgcggacgc
     7201 cgatcgcgag gttcgtgcgc agatcgtggc cgtgtccggg gcggcccggc ttccaggcgt
     7261 ccgggtgcca ggcgcgcagc gcctcggtcg tcagcgccag gcagagctgc gggacggtgg
     7321 ccccggtgag gcggccgagt gcgtggagcc gggccgtgtc gacgtcggcg acggtcgtgg
     7381 cgtaggcctg ggagggcggg gcgtcgaggg ccggccacca ggtgacgcgg cgcgggggcc
     7441 ggagttcggg caggacggcg gcccagggca cgggccgggg cggccggaag gagagggcac
     7501 gcgggcgcgg agcctcctcg gggccgagga ggcgctccag cgtcgcgacg gcggcggcgc
     7561 cgtcctggaa ggcgtggtgg gcgcggtagc agagcccgta tccgccgccg acccggtgga
     7621 cgagccagag cccccacaag ggccggtcgc gcgggagggg ttgccgcagg agctcggcga
     7681 ggaccgccgc cgggtcggtg gagccgggta gctcgtacag gtgacgctcg gggtcgaagc
     7741 gggggtcggg ctcccagtgc ggccgcccgg tgcgcccggc caaccggtgg gcgagctcgg
     7801 ggatgcgggc gatgcgcgcc ctcaggtgct ccaacagccg acccctggag ggtggttcgc
     7861 cctccagggt gacgagcccg ccgaggtgga gcgcggagtc cgtggcgtgg agcgccgcca
     7921 cgtcgaggga gagccggtcg agcaccgaga gcggaacggc cccgggaggc cggggagatg
     7981 accggagaga cgatccggcg gagggccgga cggtggagag cacaggatct gaagatcgca
     8041 cggaccgcta cgatacgtca tcatgcaatc gcaatgcgtg acggatggca tgcaccccga
     8101 cgtccccgat gtcccgaagc tccccgattt cctcgacgac gccgccgtgg cggcctggtc
     8161 ggcctccggc gcgccgctcg tcgacctcct gcgccaggcc cacacgccgg gccggctcac
     8221 cggcttccgc cgtggcggcc gggcggcggt cctcgtcacg gacccccggc acgtccacca
     8281 ggtcctcggc gtgggcggcg accggtacgt gaagcggtct caccgggcga gacccctcat
     8341 cggcgacggg atgctgaccg ccacgggcga ggcctggcgg tcccaacgac gcctcctcca
     8401 ggcgatgttc accggccggg gcatccagcg ctgggagcac cacatcgccg cggcggccga
     8461 ccgcgtcgtc ggccgctggg cggagcgggc ccgccggggc gagccgacgg acatcgccga
     8521 ggacgtccag ttcttcaccg tcgacaccat ctggcgctcg ctgaccgacc gtcccctgga
     8581 ccaggagacg tacgtcgacc tggcggccgt acaggacatc gtcgcggcgc tccccgccga
     8641 cgtgggcggc ggcgcggcgc tcccgcccga ggtggagacc gcgctcgccg cgctcgacga
     8701 gcggatgcac cgggccatcg cggaggcccg aggccgccgc acggccgacg gcgcacccga
     8761 cggcgacgct cccggggatg gtgctcccgg cggtggcgct cccggggatg gcactccccg
     8821 ggatggcgct tccggcggtg gcgcttccgg cagtggaccg agcgtcctcg accggctcct
     8881 cggcgcggcc gagaccgatc ccgcgtacac ggaccggctg atccgcgacg agctcgtcac
     8941 gctgctcgtc gccggctacg agagcagcgc ccgcaccctg acctgggcct tcgtcctgct
     9001 ggaccggcac cccgaggtca tggagcgggc ggcgggcgac gcgcgggccg tcgaggcggt
     9061 gctctccgag accctgcggc tctaccccac gggctggctg ctcccgcgcc aggccgtggc
     9121 cgacgagacg ctcgacggcc tgcggatccc cgccggcacg gacctcctcg tctgccccta
     9181 cctcacccat cgcgacccgg aggtgtggcc cgatcccgag gccttcgtgc cggagcgctt
     9241 ccccgtccgg acaccgctgc cgccgggcgc gtacctcccc ttcggcatcg gcccgcgcgc
     9301 ctgcctgggc acgcgcttcg cgatgcggga gatggaggtg ctgctcggcg ggctcctcgc
     9361 ccggttcacc gtcgagacga ccgagccggt gggcgagccg gtgttcggca tcaacctgcg
     9421 cccggccggt ccgctgtacg cgcgcgtccg cgagcggacg tgaacgcgca gccccacgag
     9481 cgggtcgact atgtcgatcc cggcgaccgg gtggtcgcgc agggcgggcg ggcgaccgga
     9541 accccgtccg gtctgctgcg ccggtacgcg gcgaccgtct gcaccgacca cgccggccgc
     9601 gtcctgctgt accggcggac cgccacggcg cccgcctatc cggaccacta cgacgtgctc
     9661 gtgggcggcg cggtgcgggc cggcgaggag taccgcgcgg cggcgctgcg ggagctccgg
     9721 gaggagctcg gctgggcggc cgcgcccggt ctcgccgagg cgtaccggat ccgcgtcgac
     9781 gatccccacg gcgactgctt cctgaccgtc caccgctggg tggcggaccg ggcaccacgg
     9841 cccgacccgg cggagatcgc ctggtgcggc ttcgtcacgc cgctgtcgat cctgaccggc
     9901 ggatacaccc cgctggtccc ggcaggcgcg gaggccgtcc gccgcctctt ccccctctga
     9961 ccggcacctc tcccgtacga ccccgacgaa ggaccccacc atgtcgacgt cctgtgcgct
    10021 gcccttacgc ggcgtctccc tggccgtccc gggcgcgctg cccggctcgg ttccgcccac
    10081 ggaccccggc cgtcccggcc tcgaccgggc ccgggcccgg ctggccaccc ggctggtcgc
    10141 ggcggccggt cccgacggcc tgctccgcgc cccgtgcgac ggccggatcc tggagtccgc
    10201 cctggccctg cggctgctga cggtgacggg cgtggacccg gacgcccagg agcggctgac
    10261 ccgctatctg aagatcacac tcgacgaggg cgaccccgac cccgtgcagg aggccgcggc
    10321 gcgggcggcg ctcggcgagt acgtggacgg gcgggccgcg ctgaaccgcc tgctcggcgg
    10381 cttcgaccac ttcaccgccg ggcgcaagcg gctgatgttc cggacggtcc tggccgagct
    10441 cggcgcgcac cccttccccg aactcgcctc gggcgagccg gacttcgagg cacgcggcca
    10501 acagcggtgg ctggtcacgg agatggccgc cctgaagacc ctgtacgcct tcggcaccgg
    10561 cgtcccgcac ctcgtcaccg aggacgactg gcgggccctc gcaccctgct cgctccccgg
    10621 cccgcccccg tacggcaacc atctcgcccg gatcctggcc ctgttggcgc tccggcaccg
    10681 gcccgggtac gcggcggccg tccgcgcgcg ggcgcgggag ctgcggacct ggctgcgcgc
    10741 ggacggcggg ctgcccttca tcaccgggat ggacgtcttc gcgacggcga ccggcgggct
    10801 cgcgctcgcc ggggcgggcg tcccggcgca cacgctgcgg gccctggccg ccgcgctggc
    10861 cgagcggcag aacccggacg ggggctgggg gttcgaccgg ggcgtcgggc agagcgacgt
    10921 cgacgacacc gcgtactgcg tggagttcct gcgggcctcg gcaccggagc tcagcggccc
    10981 cgcggtggcg gcgggcgagc ggtacctcct cgaccggcag ggcggcgacg gcggcttccc
    11041 gaccttcgag cacggcaccg cctccgaggt ggcgataacg gcggccgccg tgaacgccct
    11101 cgctcccgag cccggccacc ggccggcggt ggaggccgcg gtccggttcg tcgtggcgcg
    11161 gcaggaggac gccggggcgt tcgagcggag ctggagcctg aacgagagca acgccctgtt
    11221 ccgttccgtc ctcgcgtacg actccttccg cgccgtcgcc ccgcccggtc acgccctgga
    11281 ggccggggtc gcgcgggcgc gggcgcgggc cgtcgaccgg ctcgtcggga cgcagaacgc
    11341 cgacggcggc tgggggcacg taccggccga cccgagcgac ccgatctcca ccgcgtacgc
    11401 gctgatcgcc gtctgccggg ggcgggacgg gccgtccgtg ccgtgcgggc cgagcgcccg
    11461 gggggcggcg gagcgcgcgg tgcgccacct cctggagcgg cagcgggcgg acggtggctt
    11521 cgtctcccgc cccgaccagg cgggcccgcg gcccctcgcg taccacgtac cgctcctgac
    11581 ggacatctgt gtcctgctcg gcctcaacca cgcgcgcgcc ccgcaccccc tctgaaacac
    11641 ccgacccctt gaggaacgtc atgaccttcg acgaactgaa gaacctgctc gtctcgctcg
    11701 gcctcgaccc ggcggagatc acgcccgagt cgacccgcga ggaggccggt ctcgactcgc
    11761 tgctgctcac cgagctcgcg ctcgtcctgc gcaaggagcg gggcatcccg gtgccggagg
    11821 aggagctgta cgcggcgccg accgtcgccg cgatcgaggg cctggtcgcg cggtacgcgg
    11881 cggtggcctg atgcccgggg gccgcccggc ccgcccgggc gcggccgtca ccggcgtggg
    11941 gctcttcacg ccggcgggcg cggaccgtgc gacgacctgg gagacggtgc gtgtggggaa
    12001 gcccacggcg ggcctggagg agctggacgg catccgctac ctggcgtgcc gggcgcccga
    12061 gctgccggac gggcccggcg ggctcggcag ggcggcggtg gcccggcggc cggaccggag
    12121 cgccgcgctc gcgctggtcg cggcgcgcga ggcgctcgcc gacgccggtc tggacgccgg
    12181 gacctgggac gggatgcggg tcggggtggt cgcggggacg ggggcgggcg gcaccctcac
    12241 gtacgagcgg cagctcgcgg tggtccggga ggacgggccc ggggacatgt ccccgttcgc
    12301 cgtgcccggc gccctgccga acgcggtcgc ggcgcagctg gcggtggagt tcggcatccg
    12361 cggcccgtcg atggcggtga ccacggcgtg cgcctcgggc gccacggcga tcggggtggc
    12421 gctcgacctg ctggcgctcg gccgctgcga cgtcgtcctc gcgggcggct ccgacgcctc
    12481 gctgagctcc ttctacatcg ccggtttcga ccggctccgg gcgttgtccc accgcttcca
    12541 cgacccgtcg ggcgggctgc ggcccttcga cgtggaccgg gacgggttcg tgatggcgga
    12601 gggggccggc ttcctggtcc tggagcggcc ggccgacgcg gcggcgcgcg gggcccgtac
    12661 gcgggcgctg atcggggggt acggggcgac gtcggacgcg catcacgtgg tggcgccccg
    12721 gcccgatggc tccgggctcg ccgcggcggt ccgggaggcg ctcgcggagg cgggcgcggc
    12781 gccgggcgac gtcgacctgg tgaacgcgca cgggacgggg acgccgcgcg gtgacgccgt
    12841 ggaggcggcg gtcctcgcgc ggctgctgcc gcacgggccg ccggtgacct cgacgaaggg
    12901 ggtgaccggg cacctgctgg gtgcggcggg cgcggtggag gcggcgctca cggtgctctc
    12961 ggtcgcggag gacacggtgc cgccgaccgc gaacttcacc gagccgggcg agggcgtcga
    13021 cctcgacgtg ccgacggtcg ccaggtcgtc ccgggtccgg ctggccgtct ccacgtcggt
    13081 gggcttcggc gggcacaacg cggccctggt gatcaccgcg ccgtagggcg ggtcaggtgc
    13141 aggaggagag ggcgtccggg tcgacggcgt cgagccggac ggccagcgcg tcgagccgtt
    13201 cccgcaggtc gcggatgtcc tccagcgaga ggccggtcgc ggcggcgatc cggcgcggca
    13261 cgccgagcgc cttctccttg agcgcggtcc cgtcgccggt cggccgtacg gtcacggacc
    13321 gctcgtcctc ggggctgcgc cgccgctcga cgtatccggc cgcttcgagc cgcttgagca
    13381 gcggcgacag ggtcccggag tcgagccgca gccgctcgcc gatccccttc acgggcagct
    13441 cgccgtgctc ccagaggacg agcatgacga ggtactgggg ataggtgatc ccgagctcct
    13501 tgagggcctc gcggtagacg ccgttgaagg cgcgggtcgc cgcgtgcagc gagaagcaga
    13561 tctggtggtc gagccggagg aaatcctcgt ccgggaccgt gtcgagcgtc tccatggctc
    13621 cagggtacgc gaggacacct cacacgcgat tcagttgtgc acaactgaat agtgcgctac
    13681 taatggagtc acgccgcaga gggacaccgc cccgagggct ccgaggacag gaacggaaga
    13741 accatggacg cgatctacac cgcagtcgcc accgccaacg gccgcgaggg ccgcgccgtc
    13801 agctccgacg gccacatcga cctccccctc gcccacccgc aggccctcgg cggcaacggc
    13861 ctgggcacca accccgagca gctcttcgcc gccgggtacg cggcctgctt cgccagcgcg
    13921 atgggtgtgg tcgcccgcca ggagaagatc gacatcgcgg acgcctcggt cacggccgag
    13981 gtctccatcg gcaaggaccc ggcggacggc ggcttcggcc tcgcggtgat catgcgcgcc
    14041 gagttcccgg accacctcca gggcgaggcc ggcgtgaccc tgctggagaa gacccacgcc
    14101 ttctgcccgt actcgaaggc cacccgcggc aacatccagg tcgaactggt cgtcgagtag
    14161 ttttctgttg cttttcgcgc gcccccggag gtcatcgacc caccgggggc gttcacttgt
    14221 gagttttcac gttcgggcac gggggattcg tctgccgtac gacgggcagt catgggacgg
    14281 ccgccgggcg gtggcccacg gccgctctcc ttggggcgcc cgcgggccgg cccgccggtc
    14341 acgcacccgc acccccaccg tccgtacgca ctcccggagg gcaactcccc catggccgac
    14401 ctcaaccgcc gccggttcct tcagctgacc ggcggcgccg ccgcgctcac gatgctctcg
    14461 gagagcatcg cccgcgccgc cgcgataccg gcgcagggct ccaccggcac gatccaggac
    14521 atcgagcaca tcgtcgtcct gatgcaggag aaccgttcct tcgaccacta tttcggcgcg
    14581 atgaagggcg tacggggctt cggcgacccg cgccccgtga cgctgcccag cgggaagtcg
    14641 gtctggaatc aggaggacaa ctccgggaag gtcacgctgc ccttccggcc gaccagcgac
    14701 aagctgggca tggagtacct ccagggcctg aaccacgact ggcagggcgg ccagagcgcg
    14761 tggaacaagg gcaagtacaa caactggatc ccggccaaga ccaaggccac gatggcgcac
    14821 ctcacccgtg aggacatccc gttccactac gcgctcgccg acgccttcac catctgcgac
    14881 gcgtaccact gttccttcat cggcgcgacc gaccccaacc gctactacat gtggaccggt
    14941 tacgtcggca acgacggcac cggcggcggg cccgtcctga acaacgccga ggcgggctac
    15001 ggctggacca cctaccccga gcgcctggag acggcgggcg tctcctggaa gatctaccag
    15061 gacatcggcg acggcctgaa cgccgccggc tcctggggtt ggatcggcga cgccttccgc
    15121 ggcaactacg gcgacaactc gctgctctac ttcaacaact accggaacgc gcagccgggc
    15181 aacccgctgt acgacaaggc ccgcacgggc acgaacgcca aggccggcga aggttacttc
    15241 gacaagctcc gcgccgacgt acaggcaggc aatctccccc agatctcctg gatcgccgcg
    15301 cccgaggcct tctcggagca cgccaactgg cccgcgaact acggcgcctg gtacatcgcg
    15361 caggtcctgg acgcgctgac ctcgaacccg gatgtgtggg cccgtacggc gctcttcatc
    15421 acgtacgacg agaacgacgg cttcttcgac cacgtggtcc cgccgtacgt ccccgccgac
    15481 gcctcctggg gcaagtccac gacccccacc gcccaggact ggttccccgg caagatcggc
    15541 tacgcggccg gcccgtacgg cctcggaccc cgcgtcccga tgatcgtggt ctccccctgg
    15601 tcgaagggtg gttacacctg ctcggagacc ttcgaccaca cctcggtgat ccgcttcatg
    15661 gagagccgct tcggggtgcg cgagcccaac atctcgccct ggcggcgggc catctgcggc
    15721 gacctgacct cggcgttcga cttcacgcgc acggacacgc agccggcccc gctcccgccg
    15781 acggccggct actacccgcc ggacaagaac cgccaccccg acttcctcgc caccgccccg
    15841 gccgtcggca cgatgccccg ccaggagccc ggcaccaagc ccacccgccc cctgaagtac
    15901 gccccgtacg tggacggcgc cgcggacacc acggccggca ccttccgcct caccttcagc
    15961 ggaggccccg cggcgggcgc ccagttctac gtgacctcgg cgaaccgcac ggacgccccc
    16021 tggacgtaca cgaccgaggc gaacaagtcc ctctcggaca cctggaacac caagtactcc
    16081 aagaccctca ccgacctcac ggtccacggc cccaacggct tcctgcgcca cttccgctcc
    16141 cccggcaaga ccgccgtccc cgaggtcacc gcccgccaca acgccaccac gggcaacctg
    16201 gacctgaccc tgacgaacgc caccgcggcc gccgtcaccc tcacgatcac caacacctac
    16261 gcgggcaccc cgcagacggt gacggtcccg aagggcggca cggccaccca caccgtgagc
    16321 ctgtcggcct ccgcccgctg gtacgacgtg accgtcacga ccccgtcgca gacggacttc
    16381 ctccgccgcc tggcaggcca cgtggagacg ggcgccccga gcacgacgga ccccggcatc
    16441 ctcacgtact gacacccgtc ccccgccccg gcacctcaca cggtgccggg gcgggcacgg
    16501 cgggtgcggt cggctccgtc gtcgagcacg ctcacccggt gaccgcgata ctcgaagaga
    16561 ggcgccttcg cccgacatcc cgaggaggca gtaccagatc gacggccgaa gggatgcccg
    16621 gcaacgcgac gcgagctgcg aggtgacttc gatgagccag caagcaccga ccggagggca
    16681 ggggaacacc ggccgcgcac caggaaacgc gcaccggtcc ggaggcggcg gaggcctcgc
    16741 cggcggaggc accgtgttcg ccgcggtgct gctgtccctc tcgggcatcc tggccgtcct
    16801 ccagggcatc acggccatcg ccaaggacga cgtgtacacc cgcgtcggca actacgtctt
    16861 cgagttcgac ctgacggcct ggggatggat ccacctcatt ctcggcatcg tcgtcgtcct
    16921 gaccgcggtg ggcctcttca tgggctcgaa ctgggcgagg gcggcgggca tctgcctggc
    16981 cggcctcagc atgatcgcca acttcatgtg gctgccgtac cagccgtggt gggcactcac
    17041 gatcctggcg atcgacgtgt tcgtcatctg ggcgctgtgc accagttgga cacacacccc
    17101 cgaatgacgg tcccgacacc ccacaggagg acgtacgcca tgtccaccgc atcggaaacc
    17161 cccgtcctgg acaccctcgc cgccatgacg atcgattcga tcgagcgctg cggcctggct
    17221 ccggacatgc tcatggtcgc gcggatcgcg gccctcgccg cctcggacgc cccgccgatc
    17281 tcctacgcgg cccacatcga gatggccatc gagaccggca tgaccgccga acaggtgcag
    17341 gacgtcctgg tcgccatcgc gccgatcgtg ggcaccgcgc gcgtcatgac ggcggccggc
    17401 aacatctccg cggcactcgg catcgccatc gccgtcgcgg acgccgagat cgagacacag
    17461 ggctgagcga ggcccccacc tccacgggct gagcaagccc cccacctcca cgggctagca
    17521 ggccccccac ctccaacggc ccgcacagtg gccgggcaga aggggttcag atgccgaaga
    17581 acgtgaccac ggcggcgatg cgcgcggcac gccacgccac accggaggag cgtgcggcgc
    17641 tcggcaagga agcccggggg cgctcgccgc gctcgggcca cgccgagtac cggccgtccg
    17701 ccgacaggcc cgacccgctg gcgatcctgg aggcgcagtc ggcgacacgg gtccccgagc
    17761 tcgtcccgat ccgctacgcc cgcatgacgg agtccccgtt ccgcttctac cgcggcgccg
    17821 ccgccatcat ggcctccgat ctggccgcca ccccccgctc gggactcacg gcccagctgt
    17881 gcggggacgc ccacttgctg aacttccgcc tcctcgcctc accggagcgg cagttgatgt
    17941 tcgacatcaa cgacttcgac gagacgcttc cgggcccctg ggagtgggac gtcaaacggc
    18001 tgtcggcgag tttcgtgatc gccgcccggg ccaacggctt cgacgacgcc gagcgcaggc
    18061 gcatcgtccg gggaacggtc cgttcgtacc gcgaggcgat gatccggctc gcgaacatgc
    18121 gcgacatcga cgtctggtac gcgaagatcg acgcggaccg cctcaaggcc ctggccgcgg
    18181 accagctcca caagcgcgga cggaagaacc tggcccgcgc catggcgaag gcccgtaccc
    18241 gcgacagcct ccaggccttc gacaagctca ccgagacggt cgacggccgg cccgtgatcg
    18301 cggccgatcc tccgctgctc gttccggcga gcgacctgat gcccgacgtc gagcgcaccg
    18361 ctctcgaacg ccagttccgc agtctgatcg accggtacgg cagcaccctg cagtccgatc
    18421 ggcgcacgct cctggcggag taccgcctgg cggacgtcgc ccgcaaggtg gtcggcgtcg
    18481 gcagcgtcgg aacccgctgc tggatcttcc tgctcctcgg ccgggacgac caggacccgc
    18541 tcttcctcca ggccaaggaa gcggacacct ccgtgctcgc cgagcacgtc ggcgcgagcg
    18601 cgtaccgcaa ccagggcgag cgcgtcgtct ccggccagcg gctgatgcag gccgccagcg
    18661 acatcttcct cggctgggag cgcgtggacg ggttcgacgg caagcggcgc gacttctacg
    18721 tgcgccagct gcgcgactgg aagggcatcg ccgtgccgga gcagatgacg cccagggtca
    18781 tggaggcctt cggggaggtg tgcggggtca ccctggcgcg tgcgcacgcg cggtccggcg
    18841 accggatcgc gatcgccgcg tacctcggcg gcggcacctc gttcgaccgg gccctcgcga
    18901 cgttcgcgga ggcctacgcc gaccagaacg agcgcgacca ccaggccctg gtcgacgccg
    18961 tacgcgcggg ccggctgccc gcggaggagc tgccggcggc ctgaggcgga gacggcggac
    19021 gagcgtgtcc ccctcgggat acccggtcac cgcgcggggg gcgggccgcc gtcctcgtct
    19081 cccggcaccc tgatgccccg cagacgccgg ccctcctgga ccgcgcccag caggaagcgg
    19141 gccgccacgc cgatcagcag gaaattggcc gtcatctgtc ccgtggtcaa cagccgggcg
    19201 acttcgctgc gcggggcgat gtcgccgaag ccgaccgtgc tgaacacggt catcgtgaag
    19261 tagagggcgt cggtccgggt catcgtttcg gtgaagctcc cgggtgcgct gcgctccagc
    19321 aggtagtagg tggcggcgaa gagcaggacg aagaacggca gcgccgtcgc cacccccgcg
    19381 atggcccgga gtcccgggcg cgcggaagcc atgatcgtgt gcacctgcca ggcgaggagc
    19441 agcgccacga ggacgacgcc aaggacgagc accaccacgg tgcccgcggt gaaggccgaa
    19501 tccaacggca acaggtagta ggcggccagg acggccgcca gcgtcagggt cgaacgcacg
    19561 gcggtgagca cggccgacct gcggaccccc ggattccctt ccacgtttcc ccgttcccct
    19621 ctcgttcgca cggaacgcca tgacggtgcc gcgcccctgt cagagggcgg tcactgtccc
    19681 agacggtccc ggcacggtgc gggaggcgca ccgggaggtc gcccgtccgg ggtgcggcga
    19741 gctcggcagc ggcgcacgct gtaaggagat cgtcacgccg gtcgcggcgt ccgaagggac
    19801 agccgcggcc ggcacgagcg gcaggagatc gaccatgaag gactcgatgg tgaccttggc
    19861 agtggactac ccgctgctga acatgttctg gaccatgctg atgatcttct gctgggtcct
    19921 ctggttcatg ctgctgttcc gcatcatcgg cgacatcttc cgcgacgacg agctgggcgg
    19981 ctggggcaag gcggggtgga ccgtgttcgt catcctgctg cccttcctcg gcgtgttcgt
    20041 ctacctcatc gcccgcgggc gcggcatggg cgaacgcgag ctgaagcggg tccgccagaa
    20101 cgaggaggag ttccgctcct acgtgcgcga gaccgccggg accggcggcg gtcacgcgga
    20161 ggaactggcc aggctcgccg agctgaagga ccgcggcgcg atcacggagg acgagttcgc
    20221 gcaggccaag gccaaggtcc tcgcgagctg accacgtccg gggtgcccgc ccgtgatcct
    20281 cgacctgttc ctcatcggcc tggccatcgc tctctacccc atcccggtca tggccttcgt
    20341 cctggtcgtg tccgcacccc gcggggtgta caaggggctg gccttcatca tcgcgtggct
    20401 cgcctgcctc gtggccgtga tcgccatggt cctgctcttc acgggcgggc aaccgcccgc
    20461 gccccgctcc ccgccgtcga tcgcggcact cgccgccacg ctggtcatcg gcctgagcct
    20521 gatcgcctac agcgagcaca ggcgccgccg aagccgccgc acagcggccg tatccgcctc
    20581 acacgaaaaa cggcccaagg gttcaggccg gtcactgacg tcccggatgg accaggccac
    20641 cggatggtcc gcggccggac tggccgttct cctccagccc tggggaatgg tcagcgccgc
    20701 ggccgccacc gtcgtgaagg ccgacctctc ccaggtcgcg tccttcctgg cgctcttcgg
    20761 cttctgcgtc ctggccacgg ccggcctgct ggccatggag ctgtacatgg tgttcgcgcc
    20821 cgagaaggcc cagctcagcc tggtgaggct gcgggggtgg ctggaacgcc acaaggaccc
    20881 ggcgatcgtc ctgatctgcc tggtgctggg cctgtggctg gtgggcagga gcctgtacca
    20941 actgacaggc tgaaccccca ctcggggaca gccggaagct caaggacaac tggaaaccgg
    21001 atcgtcgtgg acgagcgcgc agatcatctg ctctccgcgc cggtcgtccg gataggtcct
    21061 gcgcagttcg gccgcgaagt cgttccactg gcgggtggtc tcggcggtgg ccccggaaac
    21121 ggcccggtcg aagttgtcgc cggtcctcga acggcgggac gcggcggtgt ccttgttcag
    21181 gtcgcggttg tgcgtgactc ggccggcgca gtcggcgtcc ttgacgccgg tggagtcgat
    21241 gtcggagtag cagccggtgg cgaggtccac gggtacgagg gcgcgcgcct cccgggtcca
    21301 gtcggcgtcc tccatggtgc tgtagcgccg gatgtcgagg aagggggcgg caccggtacg
    21361 gcccagcccg ggcgggttgt ccaggccgac cggaccgggg gcggcccggt cggaccagtt
    21421 cgcgtgcgtg tggaagtcct ggagctggtg ccagccgcgg ccgagctgtt cgagcacgtc
    21481 gcacttggca cggtcgggtt tctcgttcca cacacaggcg gaggagagat cactctgctc
    21541 ggcccggacc ttgccctggg cgtcgacgag cccgtcggcc gccaggaccg cgttccggaa
    21601 acgggcgacg gaggtacgga cacaggcgag gagct
//
