LOCUS NZ_LMEQ01000032 11443 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_6, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000032 VERSION NZ_LMEQ01000032.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 711102) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 711102) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 301400 Orig. end :: 312843 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000032.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..11443 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="2" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..11443 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..11443 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:6443](-)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core complement(5001..6443) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" misc_feature complement(561..575) /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 16.73" /tool="antismash" gene 575..1306 /gene="hemQ" /locus_tag="ASD48_RS34560" /old_locus_tag="ASD48_24975" CDS 575..1306 /EC_number="1.3.98.5" /codon_start=1 /gene="hemQ" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018564417.1" /locus_tag="ASD48_RS34560" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_24975" /product="hydrogen peroxide-dependent heme synthase" /protein_id="WP_057605812.1" /transl_table=11 /translation="MSDDAPTTESGRVPNKGKLAKDLNEVIRYTLWSVFRLKDVLPEDR AGYADEVQELFDQLAAKDVTIRGTYDVSGLRADADVMIWWHAETADQLQEAYNLFRRTK LGRALDPVWSNMALHRPAEFNRSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRR MLADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARMHVR EEVPFYTGRRKDLTELVAGLA" gene complement(1307..2917) /locus_tag="ASD48_RS34565" /old_locus_tag="ASD48_24980" CDS complement(1307..2917) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (109-482). E-value: 7.1e-23. Score: 73.4. Matches aSDomain: nrpspksdomains_ASD48_RS34565_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125237.1" /locus_tag="ASD48_RS34565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_24980" /product="alpha/beta hydrolase" /protein_id="WP_057605813.1" /sec_met_domain="PF00561 (E-value: 5.8e-27, bitscore: 90.1, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MRAAALHSAAGALLLTALSAVPAGGAPNTGGPSGSPGVALTAARA AAKGVDFGKCSAAQDLPGSMQCGTVSVPLDYAAPNGKQIELTVSRVRATHRDPHNSKHR VPRQGALVFNPGGPGGSGLYFPLIGLLPEWKRIGAAYDLVGYEPRGVGRSAPLSCQDPK RFFKGPAPAPDHPSESYKRERIAQAKAYAQGCAKRSGSALRHYNSLNNARDLDVLRAAL GEERLTFMGASYGTYFGAVYATLFPSHVRRMVFDAAVNPDPAQIWYRNNLDQSAAFESR WTDFREWIARHDDVYGLGATAEAVLSSYERARARLAAEPAGGKVGPGQLQGAFLQAGYY DDYWPARAQALSEYLKGDPKQLIAQAGPVREAAAEAENANAVYTAVECNDASWPTDWRV WDRDNTRLARVAPFETWDNVWANLPCAYWPAPRQQPVDVRTGPGELPPTLILAAERDAA APYAGALEMHRRLTGSVLVTERDAGTHGIAGGPNRCVNGHLEAYLLEGRLPVRRAACAP RREPEPAVAPAERAARPGR" aSDomain complement(1472..2590) /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS34565_Abhydrolase_1.1" /evalue="7.10E-23" /label="ASD48_RS34565_Abhydrolase_1.1" /locus_tag="ASD48_RS34565" /protein_end="482" /protein_start="109" /score="73.4" /tool="antismash" /translation="ALVFNPGGPGGSGLYFPLIGLLPEWKRIGAAYDLVGYEPRGVGRS APLSCQDPKRFFKGPAPAPDHPSESYKRERIAQAKAYAQGCAKRSGSALRHYNSLNNAR DLDVLRAALGEERLTFMGASYGTYFGAVYATLFPSHVRRMVFDAAVNPDPAQIWYRNNL DQSAAFESRWTDFREWIARHDDVYGLGATAEAVLSSYERARARLAAEPAGGKVGPGQLQ GAFLQAGYYDDYWPARAQALSEYLKGDPKQLIAQAGPVREAAAEAENANAVYTAVECND ASWPTDWRVWDRDNTRLARVAPFETWDNVWANLPCAYWPAPRQQPVDVRTGPGELPPTL ILAAERDAAAPYAGALEMHRRLTGSVLVTERDA" gene complement(3049..3825) /locus_tag="ASD48_RS34570" /old_locus_tag="ASD48_24985" CDS complement(3049..3825) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125238.1" /locus_tag="ASD48_RS34570" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_24985" /product="TIGR04222 domain-containing membrane protein" /protein_id="WP_057605814.1" /transl_table=11 /translation="MVWVLLLLLAWAVAGAACTRLCLAAVRAAAVDENAGGEHDLTLYE AAFLSGGPGRVADLTMVSMARQRRLVLARTGWATVVDPRGRDEMERSVIGAIGPEGQSR IAPARAAAAAADAVGGLADRLVRAGLAVPDGARTTVAAGVRQVRVAAVAVLALGATALL VPATPDIPRNLVALWFALPLALTLSCLAIARVEVHPYSRWASPAGQRLLGALARHAGGT GDDHTYLTSVAVRGIRAVGEPDLRAAFAHREQYGRD" gene complement(3951..4727) /locus_tag="ASD48_RS34575" /old_locus_tag="ASD48_24990" CDS complement(3951..4727) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125239.1" /locus_tag="ASD48_RS34575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_24990" /product="DUF4142 domain-containing protein" /protein_id="WP_057605815.1" /transl_table=11 /translation="MRPRPPVQGRGIFSGTGLIITGLAATLAALVFPIWSYADRSGTGV DVLNAQTVSTQYGPLSALDREFVTKVRLAGLWELPAGQQAQTKGTTEAVRTAGRHLVEG HTFLDERVRTVASRLGLALPNEPNEQQQGWLGELDAAQGEQYDWKFANILRLAHGRVFS VVAQVRASTRNSLVRELADDANTTVLDHIKILEATGFVDFDALARDMAAGSTPPITRSP GPPGPTADPGSAVPVTPSASPTYTLPPAAASPPPGD" misc_feature complement(4826..4837) /note="TFBS match to CcpA, Catabolite control protein A, confidence: weak, score: 15.87" /tool="antismash" gene complement(5001..6443) /locus_tag="ASD48_RS34580" /old_locus_tag="ASD48_24995" CDS complement(5001..6443) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: DUF692" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125240.1" /locus_tag="ASD48_RS34580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_24995" /product="DUF692 domain-containing protein" /protein_id="WP_057605816.1" /sec_met_domain="DUF692 (E-value: 4.2e-97, bitscore: 319.7, seeds: 7, tool: rule-based-clusters)" /transl_table=11 /translation="MRRLGTGIGWRPEIADAVERMPGIDWVEAVAENLCPGHLPDSLLR LRERGVTVIPHGVSLGLGDAERPDAGRLAALAERAEALGSPLVTEHIAFVRAGGPLTAS PRLEAGHLLPVPRTRDALDVLCENVRIAQEALPVPLAVENIAALIAWPGEEMTEGQFLY ELADRTGVRLLIDVANLHTNHVNRGEDPAKALAELPLEAIAYVHVAGGFERDGVWHDSH AHPVPRPVLDILTDLASRVSPPGVLLERDENFPEPAELERELGTIRAAVEAGEREGAPA RASSATGEHAPTPGTGVGTRTATGIGTRTMPRTATAMGIGTRTASGDGGAPPISEPGPA ALDEATRQRLGLAQAALLSALVAGTPVPEGFDRVRLGVQARALAAKRADVVAKVAPELP LILGSGYRNAFIAYAQSHPMHGGYRQDALDFAEQTLLGGRLTEGRARRELRRWWLDRSG PAPRPKSRLGRAGRVGRTWIRR" gene complement(6680..7402) /locus_tag="ASD48_RS34585" /old_locus_tag="ASD48_25000" CDS complement(6680..7402) /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125241.1" /locus_tag="ASD48_RS34585" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_25000" /product="peptidyl-tRNA hydrolase" /protein_id="WP_057605817.1" /transl_table=11 /translation="MTSDPAVPGDSPFRSERSTRDEAPQFVLPLVVRIERADPPARTDA LETAARAVLTLLADERALGEGEWAADVRDWQDARIRKVVRRARGAEWRRAEALPGITVM GKAAEVRVFPPVPLDGWPKDLAKLQVSGTDLEDPEPPVDIDATAPVIWQNPEVGMSAGK AMAQAGHGAQLAWWELSDAERTAWREAGFPLAVRTADPRRWRELTESGLPLVRDAGFTE IAPGSCTVVADHPALRAR" gene 7460..8320 /locus_tag="ASD48_RS34590" /old_locus_tag="ASD48_25005" CDS 7460..8320 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125242.1" /locus_tag="ASD48_RS34590" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_25005" /product="ATP-binding cassette domain-containing protein" /protein_id="WP_057605818.1" /transl_table=11 /translation="MPRELRLEAVGRRYGMRGPWVFRDVHLNPASATLTRVDGPNGTGK STLLRLLARIDAPTEGKVTGAPRTAYVPERFPAALPFTALGYLTHLGAVHGLSRAAAER AAGDWLDRFGATAHAHTPMSRLSKGSSQKVAVAQALLAEPELPILDEAWTGLDTDARAE LERAVAERTAAGSAVVFVDHDPRRLAGRADAEYTVRDGTLHRRAEAEPTAAQDGPHTTI EVHGPTAPLPPEALRLATTTEETADRTHRLTVPASHSDVLLRALLTARPPWHVVSVRPD GSRHR" gene 8317..8988 /locus_tag="ASD48_RS34595" /old_locus_tag="ASD48_25010" CDS 8317..8988 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997023.1" /locus_tag="ASD48_RS34595" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_25010" /product="hypothetical protein" /protein_id="WP_057605819.1" /transl_table=11 /translation="MTALLRYQTALLLRSQRWLPPFLLYAVFLGVGVQGGQPLLDSLGY AAAFLLPVAAWLVRICVTNEPPAARTVVAAAVGPGRAHLACVLVALTTAVVFGTAATTT VTLISDPVGNDHDKRVPVLEAAGAGLLAVLTCALLGAAVGALTAWPVLRSPGRAVPALL LAALLALVVTGSPAQAAVSGLVSGSRSATVHVPLLPLAAAALLSAVATAVACALTSRRA P" gene complement(9440..9628) /locus_tag="ASD48_RS34600" /old_locus_tag="ASD48_25015" CDS complement(9440..9628) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125244.1" /locus_tag="ASD48_RS34600" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_25015" /product="hypothetical protein" /protein_id="WP_057605820.1" /transl_table=11 /translation="MSDDSDREYCLIDATTPPRAEGPPYAECVLCRKPTEYPESYKGIT LCPVCEWQEAQRTACSG" gene complement(9739..10593) /locus_tag="ASD48_RS34605" /old_locus_tag="ASD48_25020" CDS complement(9739..10593) /GO_function="GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]" /GO_process="GO:0005975 - carbohydrate metabolic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1235: polysaccharide deacetylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015657146.1" /locus_tag="ASD48_RS34605" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_25020" /product="polysaccharide deacetylase family protein" /protein_id="WP_057606101.1" /transl_table=11 /translation="MILPVRRLAALCALGAALAPLSACGSPHAPRALRPAAPAHTSLAP ARPPTLAPGPAGLTPVFSNAPRTADKRVALTFDADMTADQGARAAAGEHFDNPGLIAAL RALKVPATVFMTGRWAEEYPDQARSLGHDPGFEVANHSYSHYAFTDDCYGLPTVPEDRM RADVERAFTAFRRAGVPDAMPYFRFPGGCYDRRALRAVSGMGVTAVQWDVVSGDAFATD ADAVARQVLEGVRPGSVVVMHCTRSAAPTTEQAVRTIVPELRRKGYRFVKVSELIGAAS GRR" misc_feature complement(10582..10597) /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 16.41" /tool="antismash" misc_feature complement(11271..11285) /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 17.92" /tool="antismash" ORIGIN 1 cactgcgcac ggtggaatac gcctccatgg ccctggtcac cctcgcctac cggcgcgccg 61 acaccgccga cgccctgccc gacggcagcg gtttcctcgt cccgccggtc gacggacgca 121 ccatcaaggc gtccaccttc tcctcccgga aatggggctg gatcgccgac gaggacccgg 181 acacggtcgt gctgcgcacc tccgtggggc gctacggaga gacggagatc ctgggccgcg 241 aggacgccgg cctcgtcgac gtctcccggc acgacctgcg cgcggccacc ggcctggacg 301 ccacgcccct cgaaacccgc gtcacccgct ggaccgacgg actgccgcag tacccggtcg 361 gccaccacgc gcgcgtggcc cgcatccgcg agcacgtcgc cgaactcccc ggcctcgcgg 421 tctgcggcgc cccctacgac ggcgtgggca tcccggcctg catcgcgagc gcgtacgcgg 481 cggtcgacca gctcggcgga gacctgagcg ccgcacggga gctcgcggcc aacccggtgc 541 agagtctgca cggcggagcg ggagaatgag agccatgagt gacgacgccc ccaccaccga 601 gtccggcagg gtcccgaaca agggcaagct ggccaaggac ctcaacgagg tcatccgcta 661 cacgctgtgg tccgtcttca ggctgaagga cgtgctgccc gaggaccgcg ccggttacgc 721 cgacgaggtc caggagctgt tcgaccagct cgccgccaag gacgtgacga tccgcggcac 781 ctatgacgtg tccggcctgc gcgccgacgc cgacgtcatg atctggtggc acgccgagac 841 cgccgaccag ctccaggagg cgtacaacct cttccgccgt acgaagctgg gccgcgctct 901 ggacccggtc tggtcgaaca tggcgctgca ccgccccgcc gagttcaacc gctcgcacat 961 cccggcgttc ctcgccgacg agacgccccg cgactacgtg agcgtctacc ccttcgtgcg 1021 ctcctacgac tggtacctgc tgcccgacga ggaccgccgc cgcatgctcg ccgaccacgg 1081 caagatggcc cgcggctacc cggacgtccg cgccaacacc gtcgcctcgt tctcgctggg 1141 cgactacgag tggatcctgg ccttcgaggc cgacgagctg taccgcatcg tcgacctcat 1201 gcgccacctg cgcgcctcgg aggcccgcat gcacgtccgc gaggaggtcc cgttctacac 1261 gggccgtcgc aaggacctca cggagctggt cgcgggcctc gcctgatcag cgccccggcc 1321 gggcggcgcg ttccgcggga gcgaccgccg gctctggttc ccggcgcggt gcgcaggccg 1381 cgcgccgcac cgggagcctg ccctccagca ggtacgcctc caggtgaccg ttgacgcacc 1441 ggttcgggcc gcccgcgatg ccgtgcgtgc ccgcgtcccg ctcggtcacc agcaccgagc 1501 ccgtcagccg ccggtgcatc tccagcgccc ccgcgtaggg cgccgctgcg tcccgctcgg 1561 cggccaggat cagcgtcggc ggcagctcgc ccggaccggt ccgcacgtcg accggctgct 1621 gccggggcgc cggccagtac gcgcacggca ggttcgccca cacgttgtcc cacgtctcga 1681 acggcgcgac gcgcgccagc cgcgtgttgt cgcggtccca gaccctccag tccgtcggcc 1741 aggacgcgtc gttgcactcc acggccgtgt acacggcatt ggcgttctcc gcctccgcgg 1801 cggcctcccg caccggcccg gcctgcgcga tcagctgctt cggatcaccc ttcagatact 1861 ccgacagcgc ctgcgcccgg gcgggccagt agtcgtcgta gtacccggcc tggaggaacg 1921 ctccctggag ctgtcccggc cccaccttcc cgccggccgg ctccgcggcc agccgggcgc 1981 gcgcccgctc gtagctggac agcaccgcct ccgccgtcgc gcccaggccg tacacgtcgt 2041 cgtgccgcgc gatccactcc cggaagtccg tccagcggct ctcgaacgcc gccgactggt 2101 cgaggttgtt gcggtaccag atctgcgccg ggtccgggtt cacggccgcg tcgaacacca 2161 tccgccgtac gtgggagggg aacagcgtcg cgtagaccgc accgaagtag gtgccgtacg 2221 acgcgcccat gaacgtcagc cgctcctcgc cgagcgcggc gcgcagcacg tcgaggtcgc 2281 gggcgttgtt gagcgagttg tagtgccgca gggcgctgcc cgaccgcttc gcacagccct 2341 gtgcgtacgc cttggcctgc gcgatgcgtt cccgcttgta cgactccgag gggtggtccg 2401 gggccggggc ggggcccttg aagaagcgct tgggatcctg acaggacagg ggcgccgaac 2461 ggcccacccc gcgcggctcg tagccgacga ggtcgtaggc ggccccgatg cgcttccact 2521 ccggcagcag cccgatcagc gggaagtaca ggcccgagcc gccgggaccg cccgggttga 2581 agaccagcgc gccctgccgg ggcacccggt gcttgctgtt gtgcgggtcc cggtgggtgg 2641 cccgcacccg gctgacggtg agctcgatct gcttgccgtt cggggccgcg tagtcgagcg 2701 ggacggagac cgtgccgcac tgcatgctgc cgggcaggtc ctgcgccgcg gagcacttcc 2761 cgaagtcgac gcccttcgcc gcggcccgcg cggcggtcag cgcgacaccg ggcgagccgg 2821 acggaccgcc ggtgttcggg gcgccgcccg ccgggacggc ggagagggcg gtcagcagga 2881 gcgctcctgc ggccgagtgg agggcggcgg ctctcatcgg gtgtcccttc ggtgcacggc 2941 ggcgacaaaa gggatggttg gttcgaccgt gggggaaggc aagcaccatc gacgggtgtc 3001 ggcgccaatg ccccttgtgc gccccccggt ggtcgagcgc gccccgcctc agtcccgccc 3061 gtactgctca cgatgggcga aggccgcccg caggtccggc tcgcccaccg cgcggatccc 3121 gcgtacggcg acggaggtca gataggtatg gtcgtccccc gtgccgccgg cgtgccgcgc 3181 cagcgcgccc agcagccgct gcccggccgg agaggcccag cgcgagtagg gatgcacctc 3241 cacccgcgct atggcgaggc agctcagcgt gagcgccagg ggcagcgcga accagagcgc 3301 gacgaggttg cggggtatgt ccggggtggc ggggaccagc agggcggtgg cgcccagcgc 3361 gaggacggcc acggcggcga cccgtacctg ccgcaccccg gccgcgaccg tcgtgcgggc 3421 cccgtcgggc accgcgagac cggcgcggac caaccggtcg gcgaggccgc ccaccgcgtc 3481 cgcggcggcc gcagccgccc gcgccggggc gatacgggac tgcccctcgg gcccgatggc 3541 ccctatgacc gaccgctcca tctcgtcccg cccgcgcggg tccaccacgg tcgcccagcc 3601 cgtgcgggcg agcaccagcc gccgctgccg cgccatcgag accatggtca ggtcggcgac 3661 cctgcccgga ccaccggaca ggaaggccgc ctcgtagagc gtcagatcgt gttccccgcc 3721 ggcgttctcg tcgacggccg ccgcccgtac ggcggccagg cacagccgtg tgcacgccgc 3781 acccgcgacg gcccatgcca gcagcaggag aagcacccag accatgccgc gtttctatgc 3841 catgcgcacc gagaaacacc atgccttgtt caccatacgg accgagcgtt gtgggtatgt 3901 gacgttccgc ttgccccgtc cggccctagg aaacggtctc gcaaccggtg tcagtcgccg 3961 ggcggcgggc tggccgcggc cggcgggagc gtgtaggtgg gggacgccga cggggtcacc 4021 ggcacggccg acccggggtc ggccgtcggg cccggcgggc cgggggagcg ggtgatcggc 4081 ggcgtgctgc cggcggccat gtcccgggcg agggcgtcga agtcgacgaa cccggtggcc 4141 tccaggatct tgatgtggtc cagcacggtg gtgttggcgt cgtcggcgag ctcacgcacc 4201 agcgagttgc gggtactggc ccgcacctgg gcgacgacgg agaaaacccg tccgtgcgcg 4261 agacgcagga tgttggcgaa cttccagtcg tactgctcgc cctgcgccgc gtcgagctcg 4321 cccagccagc cctgctgctg ctcgttgggc tcgttcggca gcgccaggcc cagccgggag 4381 gcgacggtac gcacgcgctc gtccaggaag gtgtgcccct cgaccaggtg ccggcccgcc 4441 gtccgtacgg cctccgtcgt gcccttcgtc tgcgcctgct gaccggcggg cagctcccaa 4501 agacccgcca gccggacctt cgtgacgaac tcccggtcca gcgcggacag cggtccgtac 4561 tgcgtcgaca ccgtctgcgc gttcagtacg tccactccgg tgcccgaacg gtcggcgtac 4621 gaccagatcg ggaacaccag cgccgccagg gtcgccgcca ggcccgtgat gatgagcccg 4681 gttccgctga agatgcctct gccctggacg ggcggtcgcg gccgcatggg gtgcctcctg 4741 ctcgcggcac tgcacgctag tgcgcttcgg tttgcgggac tggctggcat attactgcgc 4801 ctgcgccgcc aactgccgta cgggggtaaa cggttgcaat gggagtatct cgggcgaaac 4861 ggaaggggtg aaccagtcct tgaaacggga gaaatgcagt gaaagcagtg cgggaacgtt 4921 gtgggagcga ttgcggtgcg cgtcgcgggc cgtgcggtgt taaccccggc acactcgggt 4981 ggcccacggc ccaggcttcc tcaccgtcga atccacgtcc ggcccacccg tcccgcccgt 5041 cccaaccgtg acttcggcct cggcgcgggg cccgagcggt ccagccacca gcgccgcagt 5101 tcgcggcggg cccggccctc ggtcagccgt ccccccagga gcgtctgctc ggcgaagtcg 5161 agggcgtcct gccggtagcc gccgtgcatc gggtggcttt gggcgtaggc gatgaacgcg 5221 ttgcggtaac cgcttccgag aatgagcggc agctccgggg ccaccttcgc gaccacgtcc 5281 gcccgcttcg ccgccagcgc ccgggcctgt acgccgagcc gcacccggtc gaaaccctcg 5341 ggaaccggcg tcccggcgac cagtgcggac agcagcgccg cctgcgcgag cccgaggcgc 5401 tgacgagtgg cctcgtcgag ggcggccggg cccggctccg agatcggcgg ggcgcctccg 5461 tcccccgatg ctgtcctggt cccgataccc atcgcggtcg cggtcctggg catggtcctg 5521 gtgccgatcc cggtcgcggt cctggtcccg acgcccgttc ccggcgtcgg ggcgtgctcc 5581 cccgtggccg aagaagctcg cgcgggggca ccttcccgct cgcccgcctc gacggccgcc 5641 ctgatcgtgc ccaactcccg ctccagctca gccggttcgg ggaagttctc gtcccgctcc 5701 agcagcaccc ccggcggcga cacccgggac gcgaggtcgg tgaggatgtc gaggaccggc 5761 cggggcaccg ggtgggcgtg actgtcgtgc cagacgccgt cccgctcgaa gccgcccgcc 5821 acatggacgt aggcgatggc ctccaggggc agttcggcga gcgccttggc agggtcctcg 5881 ccccggttga cgtggttggt gtgcaggttg gccacgtcga tgagcagccg tacgcccgtg 5941 cggtcggcca gctcgtacag gaactgtccc tcggtcatct cctcgccggg ccacgcgatg 6001 agcgcggcga tgttctcgac ggcgagcggc acgggcagcg cctcctgcgc gatgcgcacg 6061 ttctcgcaca gcacgtcgag ggcgtcgcgg gtgcgcggca ccggcagcag gtgccccgcc 6121 tcgagccgcg gggacgccgt cagggggccg cccgcgcgga cgaacgcgat gtgctcggtg 6181 accagcggcg aacccagtgc ctcggcccgc tcggcgagcg cggccagccg tcccgcgtcg 6241 ggtcgctccg catctcccag cccgagcgag acgccgtgcg ggatcacggt gaccccgcgc 6301 tcgcgcagcc ggagcaggga gtcgggcaga tgcccggggc agaggttctc ggcgacggcc 6361 tcgacccagt cgatgcccgg catgcgctcg acggcgtccg cgatctccgg ccgccagccg 6421 atccccgtcc ccagtcgcct catggtcccc gcctccttag tgccccctgc gtggtgacgg 6481 tggtatggcc ccgccatcga cgcccgaacc gcccgccacc ctccttcaga gcaacatttg 6541 aggttcgggc gggaggaccg gggagccacg ggggcgccga ctggcggggc ggggcggggc 6601 gggggatggc ctgcggtgag ctccgggact accgactacc gaatgcgggc gccgggctcc 6661 ggagccaggg agccatggat cagcgggccc gtagggccgg gtggtcggcg accaccgtgc 6721 aactgcccgg ggcgatctcg gtgaacccgg cgtcccgcac cagcggcagt ccgctctccg 6781 tcagctcacg ccaccgtcgc ggatccgcgg tccgcacggc gagcggaaaa cccgcctcgc 6841 gccaggcggt ccgctccgcg tccgacagct cccaccaggc gagctgcgcg ccgtgcccgg 6901 cctgcgccat cgccttgccc gcggacatgc cgacctcggg gttctgccag atcacgggag 6961 ccgtcgcgtc gatgtcgacc ggcggctcag gatcctcgag atcggttccg gaaacctgca 7021 gcttcgccag gtccttgggc cagccgtcca gcggaacagg cgggaaaacc cttacttccg 7081 ccgccttgcc catgaccgtg atgccgggca gcgcctccgc ccgccgccac tcggcgcccc 7141 gcgcccgccg caccaccttg cggatccggg cgtcctgcca gtcacgcacg tccgccgccc 7201 actcgccctc gcccagcgcc cgctcgtcgg cgaggagggt cagtacggct cgcgctgccg 7261 tctccagcgc gtccgtgcgg gccggcgggt cggcacgctc gatacggacc accaaaggca 7321 ggacgaactg cggagcctcg tcccgggtcg aacgttcgga acggaagggg ctgtcgccgg 7381 gaacggccgg atcactggtc acgtcctcca gtctgccagg tggaagatcc aggcaaccgc 7441 gagggaaagg acggtccgca tgccacgtga gctacggctg gaggccgtgg ggcgccgcta 7501 cggcatgcgc ggcccctggg tgttccgcga cgtgcacctg aacccggcgt ccgccaccct 7561 cacccgcgtc gacggcccca acggcaccgg gaagtccacc ctgctccgcc tcctcgcccg 7621 catcgacgcc ccgaccgagg gcaaggtcac cggcgccccc cgaaccgcct acgttcccga 7681 acgtttcccc gccgccctcc cgttcaccgc cctcggctac ctcacccacc tcggcgcggt 7741 ccacggcctg tcccgtgcgg ccgccgagcg ggccgcgggc gactggctgg accgcttcgg 7801 cgccaccgcc cacgcccaca ccccgatgag ccgcctctcc aagggcagca gccagaaggt 7861 cgccgtggca caagcactcc tcgccgaacc ggagttgccg atcctggacg aggcctggac 7921 cggactcgac accgacgcgc gcgccgaact cgaacgtgcc gtcgccgagc ggacggccgc 7981 cggatcggcc gtcgtcttcg tggaccacga cccccgccgc ctcgcgggcc gggccgacgc 8041 cgagtacacg gtccgcgacg gcactctcca ccgccgtgcc gaagcggagc cgaccgccgc 8101 ccaagacggc ccgcacacga ccatcgaggt gcacggcccg accgccccgc tcccaccgga 8161 agcactccgg ctggccacca ccaccgagga gactgccgac cgcacccacc ggctcaccgt 8221 ccccgcctcc cactccgacg tcctgctccg cgccctgctg accgcccgcc caccgtggca 8281 cgtggtgagc gtccgtccgg acgggagccg ccaccgatga ccgccctcct gcgctatcag 8341 accgccctgc tcctgcgctc gcagcgctgg ctgcccccgt tcctcctgta cgccgtcttc 8401 ctgggcgtcg gcgtgcaggg aggccagccg ctgctggact cgctcggcta tgcggcagcg 8461 ttcctgctgc ccgtcgccgc ctggctggtc cggatctgtg tcaccaacga gcccccggcc 8521 gcccgcaccg tcgtcgcggc tgcggtcggg cccgggcgcg cgcacctggc ctgtgtcctg 8581 gtcgcgctga ccacggccgt cgtgttcggt acggcggcga cgacgacggt cacgctcatc 8641 agcgacccgg tcggcaacga ccacgacaag cgcgttccgg tcctggaggc cgccggggcc 8701 ggactgctcg ccgtcctgac ctgcgccctg ctcggcgcgg ccgtgggcgc gctcaccgcc 8761 tggcccgtgc tgcgctcgcc cggccgcgcg gtccccgccc tgctgctggc ggccctgctg 8821 gcgctggtgg tgaccggttc cccggcgcag gcggcggtga gcggcctggt cagcggctcc 8881 cggtcggcga ccgtccatgt gccgctcctg cccctggccg cggcagccct gctgagcgcg 8941 gtggcgacgg ctgtggcgtg cgcgctcacg tcacgtcgag caccgtgagg cggggaggtc 9001 cgggggaagc ggttacgcgg cttgcgcggc aacaaacgaa cgggcgtcgg tgatgtgtgc 9061 atcggtaacc gattacgggg gtgggtcagc gcacgggcgc cggtaaccga ttgcaggggt 9121 tggcgaacga acgggcgcca gtaaccgatt gcgcgtcgat gagacgatca ggcgccggga 9181 agcggttacg cgccgaacag acactcacgc gacggtaacc ggttacgcgt gcgcgaggcg 9241 atcgcacgtc ggtaagcgat ctcgaatcag cgaccgggcg cggcgctcgt cggcggccca 9301 cccgccggcg agcggccgcc ttccggagca cgcgacgccc ctgacccggg cgggcaaccg 9361 gttgctcgcc cggaaagcaa ccggttgtgc ggagaaaacg ggtctcgcga gcgagcacac 9421 gggcactccg agcagccggt caccccgagc acgccgtccg ctgggcctcc tgccactcgc 9481 acaccgggca cagcgtgatc cccttgtacg actccggata ctccgtcggc ttccggcaca 9541 gcacgcactc cgcgtacggc ggcccctcgg ccctgggcgg cgtggtggcg tcgatcaggc 9601 agtactcgcg gtcactgtcg tcgctcatac ctccagcgta cgtaagcgac gacggcgtac 9661 gcctcgcagg cggaccgacg tgcgaggcgg gcgaggtcca ggtgaccggc ggggtcgggc 9721 cggtgaggcg tacggggttc accgccgtcc gctcgccgcc ccgatcagct cggacacctt 9781 cacgaaccgg taccccttac ggcgcagttc cgggacgatc gtccgcaccg cctgctcggt 9841 cgtcggggcg gcgctgcgcg tgcagtgcat gacgacgacg gagccgggcc ggaccccctc 9901 cagcacctgc cgggccaccg cgtccgcgtc ggtcgcgaac gcgtccccgc tcaccacgtc 9961 ccactgcacg gccgtcacgc ccatgccgct caccgcgcgc agcgcccgcc ggtcgtagca 10021 accgccggga aatcggaagt agggcatcgc gtccggcacc ccggccctgc ggaaggccgt 10081 gaacgcccgc tccacgtcgg cgcgcatcct gtcctcgggg acggtcggca ggccgtagca 10141 gtcgtcggtg aaggcgtagt ggctgtagga gtggttggcg acctcgaagc cggggtcgtg 10201 gccgagggag cgggcctggt ccgggtactc ctcggcccag cggccggtca tgaacaccgt 10261 ggccggcacc ttcagcgcgc gcagtgccgc gatcagcccc gggttgtcga agtgctcgcc 10321 ggccgccgcg cgggccccct ggtcggccgt catgtcggcg tcgaaggtga gggcgaccct 10381 cttgtcggcg gtgcggggcg cgttgctgaa cacgggggtg agaccggccg gaccgggggc 10441 cagcgtgggg ggccgggcgg gggcgaggga agtgtgcgcg ggggccgccg ggcgcagggc 10501 acgtggagcg tgggggctgc cgcaggcgct gaggggggcg agggcggccc cgagagcgca 10561 gagggcggcg aggcggcgta cgggaaggat catcatatga agttatgagg gttgtgccgg 10621 catttgttgc gatgggtgac cgcgcctccg gtcgttcacc cgcccgggct ctcgatcctt 10681 cgggaagcgc cccggctctc ggtccccggg acgcccccgg gcgggcggag ccgcgaagcc 10741 ttcgcctccc cggcgcttcc ccgtgacgtc gcggcgcggt cgagcgggcc gggagctgcc 10801 ccgccggggg ccccggacgc cgcacgcgcc ggacgccccg gaagcggtac gcgcgccgga 10861 aacggcacgc gccggacgcg ccggggggcc ccgccgtgtc ggggccccgc ctcgcggatc 10921 cggactagcg ccgccagggc cccgtgacgg cgaaggtcgt ccctggggtg tagcagttga 10981 cgtacatcgt gtcgccgtcg ggggagaagg tgacgccggc gaactcgccc cactcggggg 11041 cctgcggcgt tccgatgttc tggcggcccc gcgccatcgc gtacacctcg ccgcccctgg 11101 tcacgccgaa gacgtgctgg gcgccgttgc cgtcctcgca gaccatcagg ccgccgctgg 11161 gcgcgaggca gatgttgtcc ggggactcgc ccgggagctg gatgtccgtg tccgggccga 11221 aggcgatgac cagggtgagg cggcggagct tggggtcgta ccgccagatc tggccgaagt 11281 ggtcggccgc cgagccgtcc gagccgcgcg cgaacgacga cacgaagtac acgcagtgcc 11341 cgccccagta acagccctcg agcttctggg cgtgggtgat gcccttgggg ccgaagtcct 11401 gcagacggac cggggtttcg acggcgaggg ggtccggtac gtc //