LOCUS NZ_LMEQ01000031 40420 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_5, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000031 VERSION NZ_LMEQ01000031.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 600179) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 600179) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 559759 Orig. end :: 600179 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000031.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..40420 /candidate_cluster_numbers="1" /candidate_cluster_numbers="2" /contig_edge="True" /product="T2PKS" /product="RiPP-like" /region_number="5" /rules="(t2ks and t2clf)" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..40420 /SMILES="" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(t2ks and t2clf)" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="neighbouring" /product="T2PKS" /product="RiPP-like" /protoclusters="1" /protoclusters="2" /tool="antismash" protocluster 1..40420 /aStool="rule-based-clusters" /category="PKS" /contig_edge="True" /core_location="[35000:37513](-)" /cutoff="20000" /detection_rule="(t2ks and t2clf)" /neighbourhood="35000" /product="T2PKS" /protocluster_number="1" /t2pks_product_classes="pentangular polyphenol" /t2pks_product_classes="tetracenomycin" /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)" /tool="antismash" proto_core complement(35001..37513) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(t2ks and t2clf)" /neighbourhood="35000" /product="T2PKS" /protocluster_number="1" /t2pks_product_classes="pentangular polyphenol" /t2pks_product_classes="tetracenomycin" /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)" gene complement(539..3526) /locus_tag="ASD48_RS33165" /old_locus_tag="ASD48_23580" CDS complement(539..3526) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1041: transcriptional regulator, SARP family" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125772.1" /locus_tag="ASD48_RS33165" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23580" /product="BTAD domain-containing putative transcriptional regulator" /protein_id="WP_057605497.1" /transl_table=11 /translation="MPPEPLRFAVLGAVRVFRGDAELELGGPQERAFLALLLVGAGRPV AVGEIVDVLWGAAPPRSAVNVVRRHVGSLRRLLEPGLAARAEGRWLVRDAGGYRLVTDG DSSDLLRFRALREEGRRIADRSPGQALELLTEALSLWRGPLAGGVPVQARAHPAFDAVD RELPAAVRQAADVALRAGRPDAVLAELRQAAARHPLDEPLQAGLLLALAAAGHRPEALA AYEAVRARLAEELGIDPGAELRDARDTVLSGMRETAVGPSGGSSAEASGGAGTDGFPAP APRSGEVPDRAGADDSVAPAPAPAPVPDPPSPSALPSPAQLPHDITAFTGRDVELDEVF ALSGADGAGPGTVVISAIGGMAGVGKTTLAVHWAHRVADRFPDGQLYVNLRGFDPSGAV LDPGEAVRGFLGALGVPPERVPHGVDAQAALYRSVLAGRRVLVVLDNARDTEQVRLLLP GSPGCLAIVTSRDELTGLVAAHGAHSLVLRPFDAVQARSFLVRRLGAERVAAEPRAADE ISALCAGLPLALACVAARAAAHPHFPLAAVAAELREAHGSLDAFARSDASVDVGTVFSW SSRAISAAAARLFRLLALHPGPDLSLPAAAALAGLPVRVTRPLLAELTGLHLVTEHSPG RYAFHDLLRAHAGELVHERHTEAERAAALNRLHHHYLHTAHAADRLLAPNADPLPPPPA PEGVHPEPLADDDRALAWLTAEHAVLLAVVETAAASGRPVQERLACQLAWSLEPFFDRR GHWHDGLAVQRTALDAARRLADPALEARGLRGLARVEGRLGLHSRSVPRLERALELFTE LGDDTGRAHTHRSLGWECDQQGDLPGALRHNRFALGLFRTLGDRAAQASVLNSVGWYHA RLGEHRRALTHCFEALAMLQELGDRYGQAATWDSIAYAHHHLGRHPHALLGYRNALALL RDLGVPYVEADILVRVGDTHLATGDHDGARIAWQRALVLLRGLNHPDAERVEALLNARD GHAGAV" misc_feature complement(3583..3596) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 18.91" /tool="antismash" gene 3734..4594 /locus_tag="ASD48_RS33170" /old_locus_tag="ASD48_23585" CDS 3734..4594 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (24-141). E-value: 8.6e-18. Score: 56.8. Matches aSDomain: nrpspksdomains_ASD48_RS33170_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036: alpha/beta hydrolase fold protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125771.1" /locus_tag="ASD48_RS33170" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23585" /product="alpha/beta hydrolase" /protein_id="WP_057605498.1" /sec_met_domain="PF00561 (E-value: 3.2e-16, bitscore: 54.7, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 2.9e-13, bitscore: 46.0, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MTPPRTGTLAVPGATLYYETLGSGPVLLLIPGGAADAGLYAGMAP ELATRYTVVSYDPRGLSRSPLDGPADTSRADEEVSVWSDDAHRLLELLSPDEEAVVLGC SSGAVVAVELLARHPERLRRVVAHEPPLLRLLADPAPHRALFAEVRETFRTEGADAAMI RLGEGLADGTDRRAPARPTELPPEIRETADRMHANLPVFLGRVLCPFSSAAPDLAALRP VAHKLVPAAGRDSRRQLPLYGPAARLAELLGRGLVEFPGGHLGAVESPKEFADRLLTVL DRSAR" aSDomain 3806..4156 /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33170_Abhydrolase_1.1" /evalue="8.60E-18" /label="ASD48_RS33170_Abhydrolase_1.1" /locus_tag="ASD48_RS33170" /protein_end="141" /protein_start="24" /score="56.8" /tool="antismash" /translation="PVLLLIPGGAADAGLYAGMAPELATRYTVVSYDPRGLSRSPLDGP ADTSRADEEVSVWSDDAHRLLELLSPDEEAVVLGCSSGAVVAVELLARHPERLRRVVAH EPPLLRLLADPAP" gene complement(4692..4985) /locus_tag="ASD48_RS33175" /old_locus_tag="ASD48_23590" CDS complement(4692..4985) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014670498.1" /locus_tag="ASD48_RS33175" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23590" /product="DUF6355 family natural product biosynthesis protein" /protein_id="WP_057605499.1" /transl_table=11 /translation="MRVRRSVLSTLGSVALVLTSLGALTAATAGPAAADPCGFYETGSD AFYNHCTSDGSRVVIKVDVAWAADYERCVGPGTSWLGSAAKIQGAYYTGRTC" assembly_gap 5375 /estimated_length=1 /gap_type="within scaffold" /linkage_evidence="paired-ends" gene 5422..>5841 /locus_tag="ASD48_RS45790" CDS 5422..>5841 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003988327.1" /locus_tag="ASD48_RS45790" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="WP_242432805.1" /transl_table=11 /translation="MRSARMILATAAASAALAIGAPGAYAGDTDHDDSSYSKEDSSSYG KEHGKEDDSSYGKEEHGKEEHGKEHGKEEHDSPHGGMHTGGGALALADDSSDRGAAKDP KYDPETYKDKDDNGGEHGKDSWNGGKEESGGWSKEH" assembly_gap 5842 /estimated_length=1 /gap_type="within scaffold" /linkage_evidence="paired-ends" misc_feature 6249..6264 /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 18.45" /tool="antismash" gene 6297..7880 /locus_tag="ASD48_RS33185" /old_locus_tag="ASD48_23600" CDS 6297..7880 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125762.1" /locus_tag="ASD48_RS33185" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23600" /product="hypothetical protein" /protein_id="WP_057605501.1" /transl_table=11 /translation="MSGDQYGRYNDTDHNTFYYVPPMPSAPPPAPADGARAVAVAVLNL SGLGLGYALVRRWALMALCWVATAVLLFVALPADPDGVPGFALVLYVLFLVAVAADGAR VGLRNRLSGLRRAPLALVLGLLLLVVPAGGVVLYDSARDEATQQMLLDRLDEADELVQA AGDKPFNSAQADYRKALGVYADLRSDHPGSRAAERVPARMKTYYTTVGAAYAQGDYCEA VEPLKYLRTVPKSLPGTDLGALKTWPDDRLATSLYECASTALTAGEANWASQYGELLTT FPESEQAAKVEPAVAAAVVRTEKDLRGAEPCSAVQRLRTLGSQIDGLESGQAAIGAALD KDGRRATTSADTGTYTCGVDQYRDGDFESARTTMTEYASAHKTAKNAGLAKKIAIAAEI AQTVPAAGKKLPTTRTGGSISVTVQNDSPDAVTVLFTGPVTGSFTLKACGSCKAYSLGS TINPSFEPCNDSGKNYPQRTISLPVGTTYFLHKPNGDSSATPASDTAKLESGYIYTECA YTTQSLGTGL" gene 8027..9400 /gene="dacB" /locus_tag="ASD48_RS33190" /old_locus_tag="ASD48_23605" CDS 8027..9400 /EC_number="3.4.16.4" /GO_function="GO:0004175 - endopeptidase activity [Evidence IEA]" /GO_function="GO:0009002 - serine-type D-Ala-D-Ala carboxypeptidase activity [Evidence IEA]" /GO_process="GO:0009252 - peptidoglycan biosynthetic process [Evidence IEA]" /codon_start=1 /gene="dacB" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014669120.1" /locus_tag="ASD48_RS33190" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23605" /product="D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase" /protein_id="WP_057605502.1" /transl_table=11 /translation="MNDIKAETPVHSFAPGGRRRHRKARQSGTGVRRAMVLALALPVTS AALAGPSAFAAEKGIGTTAEDTAAGRTLDADDRQMVANLESRVLDRRLGSEVSGVVLDS ASDTTLWDHNGATALMPASNTKLATATAALTVLGPNHTFTTKVVYGNGTLTLVGGGDRT LTGADLAELAKNAVAGLKAAGLTSVRVAVDDSLFGAPTLANGWNTGYYPDSVAPVRALV VDGHGVQDTSLDAGQVFAQQLTAAGVAVDGAVTRAEASPGDVPVARHRSAALSEIVHKM IKVSDNNIAETLLRMTALGAGRPATFEDGTDVVRKVLSLRYGVSLDNFEIYDGSGLSRA NRIPAATLAEILELLTESRYSPTLGSILDGLPVSGEAGSTLGPEWGRFDDVNSMCAVGK VHAKTGTLTGAIALSGLTQGKDGKWKVFSFIENNSTANPNDIKDAMDGLAATVNGCWA" misc_feature 9480..9495 /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: weak, score: 16.03" /tool="antismash" gene 9605..10303 /locus_tag="ASD48_RS33195" /old_locus_tag="ASD48_23610" CDS 9605..10303 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family DNA-binding response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125760.1" /locus_tag="ASD48_RS33195" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23610" /product="response regulator transcription factor" /protein_id="WP_057605503.1" /transl_table=11 /translation="MASVLIAHDQSLQRVGLRMLLTAEPDLSVVGDTASGPEAVRMSAA LRPDVVLLGGHRPATDDIETIRRIAHPPHLTAVSGPAGPLGQQPRILVLTSTGDEGYAY AALRAGAGGFLPKDATPHELTAAIRVVAAGDAVITPELTRALIDTVRHERAPRPGERAV GLDTFTGRERDVLVAVASGWSNAEIAARLSIAPTTVKSHVSHILAKIGARARVQAVAFA YEYGLVHPAA" gene complement(10384..11364) /locus_tag="ASD48_RS33200" /old_locus_tag="ASD48_23615" CDS complement(10384..11364) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125737.1" /locus_tag="ASD48_RS33200" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23615" /product="hypothetical protein" /protein_id="WP_057605505.1" /transl_table=11 /translation="MPRVPRSAGVTAATLALGLLATAPAVGDEPTVSAPRVVAHFDLAK GQSPENIALEPDGSADLTFSSARQVVNVTRQGRTRILATLPAVTNPQTPVVGRAVVLGI ARAQDGTLYVNYATGTRATGIWRIPSGGGRPRQIAQLPPSGFPNGLALDERRGVLYVAD SVLGTVWRVPRSGGKPTAWAEGALLEPLNAPPAARVGVNGLKIHRDAVWVSNTNAGTLL RIPVRESGCAGAIETRAKSLFAIDDFAFVDRHRDTVLAALIGGSEIAQVQRDGTHRIVL TKKDGLANPTSVAVRGRTAYVPSAAYFKQPDPNLLLARVHQRDRG" gene 11609..11899 /locus_tag="ASD48_RS33205" /old_locus_tag="ASD48_23620" CDS 11609..11899 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125738.1" /locus_tag="ASD48_RS33205" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23620" /product="zinc-ribbon domain-containing protein" /protein_id="WP_057605506.1" /transl_table=11 /translation="MIIFGTKGYLYQLAILTLVCGRCGNPAAHTLRKRVTKFTLFFVPL FPISTSHATQCTFCGAEQKLTKEQAEQLTAQAAGGVGGQAYGQPHQQPHQH" misc_feature complement(11617..11634) /note="TFBS match to HipB, Bacterial antitoxin HipB, confidence: weak, score: 19.59" /tool="antismash" gene complement(11914..13008) /locus_tag="ASD48_RS33210" /old_locus_tag="ASD48_23625" CDS complement(11914..13008) /codon_start=1 /gene_functions="transport (smcogs) SMCOG1205: ABC transporter, carbohydrate uptake" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125739.1" /locus_tag="ASD48_RS33210" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23625" /product="substrate-binding domain-containing protein" /protein_id="WP_057605507.1" /transl_table=11 /translation="MRTRRRAVVAVLAAALLTMPLAACGGDEKAAGEGFTVGLLLPSRM VPRWEHADRPLIEAQVRKLCPGCRTEYANAESDVTRQRQQMISMVTKGARVLILDAADT RALRSSIQEADRAGVPVIAYDRLAEGPITGYVGFDGVMVGRLQGEALLKALGLKPGQRA ASDDVVMMNGDPTSPNAESYRKGALSVLSGEVRIARSYNTADWSTQNAHTNMSAAIAAL GPDRIDAVLAANDNIAAGVVAALKRAGVTELPPVTGQDADLDAVRRVVKGEQYMTVYKP FAKEAAAVAAMAVAVGRGEDPRDTATTTVDSPTTKRVPAVLLQPRPVTARDIERTLVKG GLYTTAQICTRELLTACARAGLTR" gene complement(13005..15353) /locus_tag="ASD48_RS33215" /old_locus_tag="ASD48_23630" CDS complement(13005..15353) /GO_function="GO:0016791 - phosphatase activity [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1054: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125740.1" /locus_tag="ASD48_RS33215" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23630" /product="SpoIIE family protein phosphatase" /protein_id="WP_107104457.1" /transl_table=11 /translation="MRTCLDRALTFAGATLAAVYAPEVGTRELQLVDTSGSVSSGPSPP ERLPLSGDSPAARAFRTDHPLWLTAGTPLGALPLGIQGSRLGCLLVLGASPEGFEAEQR RFLERYADAVAALLPPGADPPMPTPLLGPALRSLRVGSFVLAPDTGLIEADDTLLELVG ITPDDFDGKVDTLLAHALPEDMHALMSVLEPTTDAFGRRDLEFRVRGPTGEMRWLSLSC RAEPGTGDGPAQVLGVVTATPVLRRGGDDVSRIQWLTAALDDAATVRDVGRVVVAALRE PLAADHVALAAVQDDRVMVTALDPPQPGAWPEVWRTEWRTEWPDAPLRALPTLQAALRD GRMDLWPAGTPLEAGLAGIGAGGLAVLPLPAKGQVAGVCLVGWDRPHEFVPEERSLLTA TAALVGQALKRAHAHDAEQELATMLQRSLLPRRLPELPGGTAVARYLPARRGLQVGGDW YDVIALSQDRVALVIGDVQGHSAGAATIMGQMRTAVRAYAIEGHPPDVVVSHANRLLVG METDLFATCCYAELDLEEGNVLFVRAGHLAPMLRLPDGSTEEVEVAGGPPLGVLAEADF PMTSVELAPGTVLALVTDGLVEAADLPLDEGMRRTRVALAAADPADPGKMADELLGDDG RREDDVALLLLRYDGMTTRPIRAGWMVWRLPDAVMHARRFTARTLRRWKVQEAADAVLL VVSELVTNALVHTQGPVRLDLVLRGDRVRVSVSDSSPRAPAKPVIVDWEATGGRGLLLV EAMSDAFGSVPVAGGKQVWSEIAVPEGVP" gene 15485..16576 /locus_tag="ASD48_RS33220" /old_locus_tag="ASD48_23635" CDS 15485..16576 /codon_start=1 /gene_functions="transport (smcogs) SMCOG1205: ABC transporter, carbohydrate uptake" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125741.1" /locus_tag="ASD48_RS33220" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23635" /product="substrate-binding domain-containing protein" /protein_id="WP_057605509.1" /transl_table=11 /translation="MKACIRDTAAAVTAVSTAIVLTACGADSPDEPGTDRSRQRIGLLL PDVTTPRWETQDRPLLEKKIHELCPDCAVEHANAKGDVALQQEQMDSMITKGVDAIVLV AVDARSLGPAVTKAHEADIPVISYDRLSEGPISGYVSFDGKEVGRLQGRALLTAMGDKV PGAEIVMMNGDPSDPNTKSFQDGALSVLEGKVKIGKAYDTLQWRREAAHMNMSGAIAAL GVESIDGVYAANDGLAAGSISALKANKVDPLPPVTGQDAELSALRRIVGGDQYMTVFKP FGPEAAAGGAMAVAAVRGESLGQVATAEVPTRGGEAVAAVLLTPVSVTVDNIEDTVVKD GLHTVRQICTPQLRAACERAGLT" gene 16779..17990 /locus_tag="ASD48_RS33225" /old_locus_tag="ASD48_23640" CDS 16779..17990 /codon_start=1 /gene_functions="transport (smcogs) SMCOG1113: inner-membrane translocator" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125742.1" /locus_tag="ASD48_RS33225" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23640" /product="ABC transporter permease" /protein_id="WP_057605510.1" /transl_table=11 /translation="MVTRVRAAARAVRSGPAVLRRRLSAGELGSLPVVLVLAVVWITFQ SLNENFLSPRNLSNLSVDIVGTGMIAVGIVFVLLLGELDLSVGSISGLAAAVFAVLNVN NGVPEWLALIVAVLAGTVAGTVQGYSIARTRVPAFVVTLAGLLTWNGLMLSVLGDSGTV NLDENGLVAKLTSYYFTDDAVAYGLAAVAAGAVFLVCDRDRRRRRAIGMPHRSARAIAL RTAAVAVVAFGVAYLLNRFQGLPLALLIFLVVVAGLDVVLRRTPYGRQVYALGGSVEAA RRASLSVTWVQTAVLAASGTMAAVGGLFLASRITSVSQSSGSGVLLVNAIAAAVIGGTS LFGGRGSTWSAVLGMLVIQSIASGMAITDTPPAVQFVITGGVLFAAVIIDSLSRHSQAT RRRA" gene complement(18038..19171) /locus_tag="ASD48_RS33230" /old_locus_tag="ASD48_23645" CDS complement(18038..19171) /codon_start=1 /gene_functions="other (smcogs) SMCOG1087: hypothetical protein" /gene_functions="biosynthetic-additional (t2pks) OXY (Score: 33.9; E-value: 4e-11)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125743.1" /locus_tag="ASD48_RS33230" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23645" /product="NAD(P)/FAD-dependent oxidoreductase" /protein_id="WP_057605512.1" /transl_table=11 /translation="MTTDVTIIGAGLGGLTLARVLHVHGITATVYEAETSPNARAQGGM LDIHEDNGQPALRAAGLLEEFRGLVLEGRQATRILERDGTVLFEDPDDGTGGRPEVQRG ELRRLLLDSLPAGTVRWGHKVSGVRALGEGRHEVTFADGGTVVTSLLVGADGAWSRVRP LLCAASPAYTGMSVVEMYLFDGDTRHPDRAKAVGGGSLLALAPGRGIVAHREKGDTLHV YAMLSEPQDWFAAVDFTDAAGAGARIAQAYEGWAPELTALITDADTAPVLRPLHALPIE HRWDRVPGVTLLGDAAHLSVPNGEGANLAMYDGAELGRALAAHPDDVEAALTAYERAMF PRSAEAAADGTRLHELMFGDLAPHGLIAAFVEDEQIR" gene 19533..20324 /locus_tag="ASD48_RS33235" /old_locus_tag="ASD48_23650" CDS 19533..20324 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011436056.1" /locus_tag="ASD48_RS33235" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23650" /product="DUF899 family protein" /protein_id="WP_057605514.1" /transl_table=11 /translation="MTTTPHDPHDPATSPPGRPPVVDLGTWQTARDELLVREKAHTHEG DALAAARRRLPMVEFDGTVEVVGPEGPVPFLDLFQGRDELMVYKHMWYDDTPHQGQCEG CTTTAWHLKDAVYLNARGVSFAILTTGRWDEVASYVEFMGYTQPWYSVREVAAPVGGDM GYLTCFLRDGDRTFLTYSTTGRGNEPVNGSLALLDRTPYGRGEAWEDNPEGRPEGGSPC WSWRTDADGNATWGPTSRPVPQWTRPGATPVETLGRHGPHH" gene 20432..21715 /locus_tag="ASD48_RS33240" /old_locus_tag="ASD48_23655" CDS 20432..21715 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003994620.1" /locus_tag="ASD48_RS33240" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23655" /product="GNAT family N-acetyltransferase" /protein_id="WP_057605515.1" /transl_table=11 /translation="MDIRPTTDQDLGVFVDTLHAAFGRFPETPAEGGGGVWWAALEMDR NLLAVTADGQPVGTAGAYSFELTLPGAIPVPAAGVTAVGVLPSHRRQGVLGAMMRHQLT GLRARGEFLSVLLASEALIYRRFGYGPATYTRRLTVPRHKGDLALPRARATADAPVSGP TSGPASGTPSGTASGTASGTIELLRRAECGEILEEVYDRYRRAQPGALSRPHRWWAVRA GQPPIAPAARYVAVHRNADGVPDGYACYSLGERDTLTVDETIAVDDAVFTALARFVLGH DLVGEVVFRHFPPEHPLRWQFADFRAGQVSDDTDWLWVRLLDVPRALTARGWFTDGELV LDVDDPFLGERGRYLLTVRDGKAGCVPTDREPDLSLDVSDLGSVYLGGTAPSTLVRAGH IRAHRPGAAVLADALFRAERPPHCLHWF" gene 21939..24215 /locus_tag="ASD48_RS33245" /old_locus_tag="ASD48_23660" CDS 21939..24215 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125746.1" /locus_tag="ASD48_RS33245" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23660" /product="nitrate- and nitrite sensing domain-containing protein" /protein_id="WP_057605516.1" /transl_table=11 /translation="MARRLRAVLLIPVLVALVLGGVRVKRSVDTWQDADDAVRVAELIQ AANKYASDAINERDLSVIPLLTGARTSDTVVQARKITDADARVFDAAVGRMPKTAGLVR RVQLVRAGEAQLTAVRANAFTSRMSGVRTEESYHTVQHPLMEISNELGFGSSSQASIGR TLYAVSLTQAAESLIRSIGTHLLVEDRDRLAPGELASQLASFRSYAYLEQVGLQEYVGA GTTEDVTRLQQALAAAEERGRQQTAAAAAQAAAAGRTFVAPPGIDVMIAEIADGKPAGE LAARGITPESFFAASTLGFDAYRGIQVNLTDAALTSAHAIADDARRDAVVNAALVLASL LVAFLLASWVARTMSTGMRRLSASAIEIAGRRLPALVDQMSRPDSGEVDTRVVPIPIHT TDEIGEVARAFDLVHREAVRLAAEQALLRGNINAIFTNLSHRGQSLIERQLALITSLED NETDPEQLENLFRLDHLATRVRRNGENLLVLGGERPAEQWDRPLPLVDVVRAACSEVEQ YERIRLSGLPEAQIDGRTVPDLVHLLAELLENATVFSSPHSEVRVTAVRLPDGRITVEI HDEGIGLAADDFAVINRKLADPPTVDVGISQHMGLFVVGRLAERHGILVRLRPSGEKSG TTSLVMLPATVTRPLPGTLPDSDTLALALLKNVQRPEYAGATVSAGGQDSGDAFTDYES WQDEPPGRRPADAPSAAEPSAAGPSAAEPSVTGPSVAEPAMTSRARPRRLSRRAPRNGR RPRTG" cand_cluster 23701..35677 /candidate_cluster_number="2" /contig_edge="True" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="2" /tool="antismash" protocluster 23701..35677 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[28700:30677](+)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="2" /tool="antismash" proto_core 28701..30677 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="2" misc_feature complement(24535..24549) /note="TFBS match to MexT, Global virulence regulator, confidence: weak, score: 17.51" /tool="antismash" misc_feature complement(24597..24611) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: weak, score: 14.63" /tool="antismash" gene 25053..26510 /locus_tag="ASD48_RS33250" /old_locus_tag="ASD48_23665" CDS 25053..26510 /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1020: major facilitator transporter" /gene_kind="transport" /inference="COORDINATES: protein motif:HMM:NF019310.4" /locus_tag="ASD48_RS33250" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23665" /product="MFS transporter" /protein_id="WP_107104458.1" /transl_table=11 /translation="MEAGRRRGLPGVRGVGNVGTSPIRRPPGPAHEERPVTDGEPRRTQ RTDPSVPAHGADRTDRPAPRNARPARPSRDLRILWWVNAADGLGSQASGLVLPLLLLQL GHSPGTAGSLASVAALTGVVLGPLVAVPADRGRRRRLMTGSAALAALATGVLALACLGR PALWVVVSLALAERLCAVAYEAASRGALVRLATVDELPRAAAGMQMGDQAALVLGPVLG GALFQLARPLPFLADALSYAVAALGVRAVRTPLDTPAPTTPSGSGARRRGTWPERFAAA RAGVVTVAGSPVLRLVLVWTSAAGGALTLLFYTALFRLGGDERSTAAGVVLAVSGATGL LGSLAAAPAVRRIGAARLLTVTAWLLPLPCCALMWVDGAVGWGVAFAGLSLLVPLITVV LAGAAVACTPVELQSRTASVLGSVSALAAAGAPALAAVLVTVWSSRTPALLVTVLFAAL AGYTQLRAPVVLRAGAAAAAGTGDGRG" gene 26503..28326 /locus_tag="ASD48_RS33255" /old_locus_tag="ASD48_23670" CDS 26503..28326 /NRPS_PKS="Domain: Abhydrolase_1 (364-505). E-value: 5.9e-10. Score: 31.1. Matches aSDomain: nrpspksdomains_ASD48_RS33255_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_S9" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010359085.1" /locus_tag="ASD48_RS33255" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23670" /product="alpha/beta fold hydrolase" /protein_id="WP_057605613.1" /sec_met_domain="PF00561 (E-value: 1.1e-07, bitscore: 26.8, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Peptidase_S9 (E-value: 6.4e-35, bitscore: 115.5, seeds: 64, tool: rule-based-clusters)" /transl_table=11 /translation="MADDFTVFLGALPQVCPRDARRMVLTADADGRCEVFTWDAATRST RQVTDRPRGTVHCAIDADAYVWWFDEDAEGRGHWWFQPFDGGCRVPGLPGVPAALPRGL AVTADGTVAAALASRDGGTRLFAGRRGRVPREILGIAGEGRLGGVTPEGDLVALATVSD GDTSVVVVTPAGRVVARLPETRGPAGRFWCRGFSPRPGRSALLLVHELEDGYRLATWTP SGGLVTHSWCRFDTEITARWYPDTDEVLVRQERHGRSLLHRVRLHDRTRRVLPTPAGSL LDAAPRPGGGLHYLWTDTAHPPVPHATDGVALPTPGPLPRVPGRHTEVWTRTPDGPVHT LLSLPRPDGGRPGGADADGDEAPPPAVFLVHGGPADHDRDAYDATVHSLVASGYAVARV NYRGSTGYGPRWRRTLGPGVGHPQVDDLAAVRADLVGRGLVDDRATALWGVSWGAYLVL LALGTRPGLWQAGVAVKPVADWVTAHRLTTPALRALDVRWFGGTPEQVPRRYAHSSPLS FAAQVRAPLLVVGADNDVKCPPEQIRSYLGALTAAGVAHEQMWLDTGHDGYDGAAHVAV LRRSLTFLRARLPAPAPPSRPPARPGGPRPR" aSDomain 27595..28017 /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33255_Abhydrolase_1.1" /evalue="5.90E-10" /label="ASD48_RS33255_Abhydrolase_1.1" /locus_tag="ASD48_RS33255" /protein_end="505" /protein_start="364" /score="31.1" /tool="antismash" /translation="PAVFLVHGGPADHDRDAYDATVHSLVASGYAVARVNYRGSTGYGP RWRRTLGPGVGHPQVDDLAAVRADLVGRGLVDDRATALWGVSWGAYLVLLALGTRPGLW QAGVAVKPVADWVTAHRLTTPALRALDVRWFGGTPEQ" gene 28404..28526 /locus_tag="ASD48_RS46075" CDS 28404..28526 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004993374.1" /locus_tag="ASD48_RS46075" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="hypothetical protein" /protein_id="WP_266720057.1" /transl_table=11 /translation="MQKDIIHNDPLAGDEENRKPGIGITITIPFRNAAESDDEE" gene 28701..30677 /locus_tag="ASD48_RS33260" /old_locus_tag="ASD48_23675" CDS 28701..30677 /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: TIGR03975" /gene_functions="biosynthetic-additional (rule-based-clusters) PF04055" /gene_functions="other (smcogs) SMCOG1277: Radical SAM domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003958123.1" /locus_tag="ASD48_RS33260" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23675" /product="RiPP maturation radical SAM C-methyltransferase" /protein_id="WP_057605518.1" /sec_met_domain="TIGR03975 (E-value: 3.1e-188, bitscore: 621.9, seeds: 14, tool: rule-based-clusters)" /sec_met_domain="PF04055 (E-value: 1.4e-11, bitscore: 40.1, seeds: 518, tool: rule-based-clusters)" /transl_table=11 /translation="MRVLLVNMPWSPIDLPSLALGILKRSVDDHVQDATCEVLHANLEF TDWITARSEFTAEDYEYYALSSYFLGCGDWVFSSALYDDPAWRDAQFVDAMTSKLRRSR MRMTRELHRLVPEFVDEVARRVVALEPDVVGFTSTFQQNTAALAAARHIKRLAPQVVTV MGGANCDAEQGAAVHRNFPFVDYVVRGEGEDAFPRLLTALRDGDPSAVEAVPGLCHRTP HSGHTANPMPTGPLPPSAILPPDYSGYFERLAASVARNWVEPKLVVEGARGCWWGEKHH CTFCGLNGSFMEFRSKSPDVFYQEIMDLAERHRVLDMYVVDNILDMRYLSTVLPRIVDS GYDLRMHIEIKANMRRPQLQVLADAGLIYVQPGIESLNSRVLDLMDKGVSGCQNVRMLR DAAETGLSVSWNYLHGFPGETADDYEPVIRQLPALEHLNPPVDLSARIAIERFSPYFKR PELGFTGLRPEEHYLFTYDLPEAELHDLAYVFQAPERGITEPTVGLLNDGIAAWKKHHA DARLTHTDLGDRIVLVSRRPSFAWRTMQLTDPFETAVFRLLDQPHTVVALHRKLTSAAV AAGDAPRTAREVEALLTEWVAQGVVFTDAGQYVHLAPAAVNQDLLRLDYMRHTHTRGEA TAPAGAAPEPEPEPAPAPAPVPS" gene 30742..31401 /locus_tag="ASD48_RS33265" /old_locus_tag="ASD48_23680" CDS 30742..31401 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018569704.1" /locus_tag="ASD48_RS33265" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23680" /product="DUF5825 family protein" /protein_id="WP_057605520.1" /transl_table=11 /translation="MTATAPDLAIRAWRDLDPQARHLPGMSLGSLPVTARDREADRLWD LGVRHAELDAPVDLSTDDPAVHRRTVDRLCLVRDLTARAVSVDWDLRLSPRESAHQWKV LSHLQPPRTLTGLDDAEEALHAWRTRHYLCKLVWRQGPGFVQIRDRRWGDLRRFTAVEP HYREAIALLGPGVHHADVPADVLEEFAAEHLLLRVGELAWWLPYRVSRWLQEAMAV" misc_feature complement(31523..31541) /note="TFBS match to HgtR, Hydrogen-dependent regulator, confidence: weak, score: 19.26" /tool="antismash" misc_feature 31526..31544 /note="TFBS match to HgtR, Hydrogen-dependent regulator, confidence: weak, score: 18.53" /tool="antismash" misc_feature 31532..31546 /note="TFBS match to SypG, Regulator of biofilm formation and host colonization, confidence: weak, score: 18.26" /tool="antismash" gene 31540..32688 /locus_tag="ASD48_RS33270" /old_locus_tag="ASD48_23685" CDS 31540..32688 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007388051.1" /locus_tag="ASD48_RS33270" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23685" /product="right-handed parallel beta-helix repeat-containing protein" /protein_id="WP_057605523.1" /transl_table=11 /translation="MKKCHIAYLACTAALIGTGLGAAPPVAAHRIHVVHPGESIQKAVD SARPGDTVLLTYGTYHESVDVSTPGLTLRGVGRGTVLEPATAAATGSTAPSTGSAAGSG AVKGSKGSKGTKGPKAATSCAASGNGICVVGTKDHNVDDVTVASLTVRGFAKTGVYATE ADGLTVRHVTAEKNGVWGIATEHSVHGLFRHNTARDNGDAGLFLANTVKEELGATDTEG TVVERNRLEGNRIGVTVRRLRNLTLAGNHLTGNCAGVFVVGDENKPKAGFVTVRENRIV RNNKSCPKTARLDALQGSGIVLTGAEDSLVTRNVIKDNVGKSPLSGGIVLFKSFVGTTS DRNRISDNLLRGNSPDLVNTDTGKGNTFEGNSCRSSKPAGLC" gene 32729..33757 /locus_tag="ASD48_RS33275" /old_locus_tag="ASD48_23690" CDS 32729..33757 /GO_function="GO:0008171 - O-methyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1042: O-methyltransferase" /gene_functions="biosynthetic-additional (t2pks) MET C6|C8 (Score: 511.4; E-value: 2e-156)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016433750.1" /locus_tag="ASD48_RS33275" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23690" /product="methyltransferase" /protein_id="WP_057605525.1" /transl_table=11 /translation="MTTTQSAPPPSMRLRELAFGAACAAAVRAAARLGVADALGDSPMA VEDLAAAVKTEPRPLRRLLRALSCYGVFAEGPDGTFAHTDVSRLLREDDPNSLRAITLW CTEPWTWDAWPMLDEAVRTGRNVVEDLYGKEFFPYLNEDAPESADVFNRAMTTSSVQSA RDVAEFLDLTGSSSVADIGGGQGHVVASLLDKYPSMHGALLDLPRVVENAVPRLLAGGD LAGRARVVPGDVRASVPVKADVYVIKNILEWDDESTARALRNVREAGGPGTRVVVIENL VDDSPSMRFSTAMDLLLLLNVGGAKHTTQSMVDRLTEAGLVIDDISPVNPYLHAFDCHV PG" gene complement(33877..34209) /locus_tag="ASD48_RS33280" /old_locus_tag="ASD48_23695" CDS complement(33877..34209) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1225: Polyketide synthesis cyclase" /gene_functions="biosynthetic-additional (t2pks) CYC C4-C21/C2-C23|C2-C19 (Score: 160.3; E-value: 2.8e-50)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014672282.1" /locus_tag="ASD48_RS33280" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23695" /product="TcmI family type II polyketide cyclase" /protein_id="WP_057605527.1" /transl_table=11 /translation="MHQALIVARMAPGSATDIAKVFEESDRGELPRLVGVNRRSLFQFG DVYMHLIESERDPGPAIAKITGHPEFRDVSERLAAYVSAYDPETWRSPKDAMAQRFYLW EREPAG" gene complement(34230..34709) /locus_tag="ASD48_RS33285" /old_locus_tag="ASD48_23700" CDS complement(34230..34709) /NRPS_PKS="Domain: Polyketide_cyc2 (3-144). E-value: 3.5e-18. Score: 58.3. Matches aSDomain: nrpspksdomains_ASD48_RS33285_Polyketide_cyc2.1" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1128: cyclase/dehydrase" /gene_functions="biosynthetic-additional (t2pks) CYC C9-C14 (Score: 241.2; E-value: 7.7e-75)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016433752.1" /locus_tag="ASD48_RS33285" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23700" /product="SRPBCC family protein" /protein_id="WP_057605529.1" /transl_table=11 /translation="MTGHTQNEITIAAPLDLVWEVTNDLENWPRLFSEYASVEILSREG RKTTFRLTMHPDENGTVWSWVSEREPDRDTLTVKARRVETGPFAHMDIHWRYEEVPAGT RMVWTQDFAMKPEAPVDDEWMTDNINRNSKVQLGLIRDRIEKTAAERGATRGLTD" aSDomain complement(34278..34700) /aSDomain="Polyketide_cyc" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33285_Polyketide_cyc2.1" /domain_subtypes="Polyketide_cyc2" /evalue="3.50E-18" /label="ASD48_RS33285_Polyketide_cyc2.1" /locus_tag="ASD48_RS33285" /protein_end="144" /protein_start="3" /score="58.3" /tool="antismash" /translation="HTQNEITIAAPLDLVWEVTNDLENWPRLFSEYASVEILSREGRKT TFRLTMHPDENGTVWSWVSEREPDRDTLTVKARRVETGPFAHMDIHWRYEEVPAGTRMV WTQDFAMKPEAPVDDEWMTDNINRNSKVQLGLIRDRI" gene complement(34711..34965) /locus_tag="ASD48_RS33290" /old_locus_tag="ASD48_23705" CDS complement(34711..34965) /GO_function="GO:0000036 - acyl carrier activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: PP-binding (9-73). E-value: 9.9e-11. Score: 33.8. Matches aSDomain: nrpspksdomains_ASD48_RS33290_PP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1129: acyl carrier protein" /gene_functions="biosynthetic-additional (t2pks) ACP (Score: 70.5; E-value: 2.1e-22)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_013002012.1" /locus_tag="ASD48_RS33290" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23705" /product="acyl carrier protein" /protein_id="WP_057605531.1" /sec_met_domain="PP-binding (E-value: 1e-08, bitscore: 30.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTDRITVEELAELMKKSAGVTVAPEVLRRDDTGFDSLGVDSLGLL GIVGELENRYGTPMPPDAERSKSPRQFLDLVNSALLTGA" aSDomain complement(34747..34938) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33290_PP-binding.1" /evalue="9.90E-11" /label="ASD48_RS33290_PP-binding.1" /locus_tag="ASD48_RS33290" /protein_end="73" /protein_start="9" /score="33.8" /tool="antismash" /translation="LAELMKKSAGVTVAPEVLRRDDTGFDSLGVDSLGLLGIVGELENR YGTPMPPDAERSKSPRQFL" gene complement(35001..36248) /locus_tag="ASD48_RS33295" /old_locus_tag="ASD48_23710" CDS complement(35001..36248) /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (8-408). E-value: 2e-26. Score: 84.8. Matches aSDomain: nrpspksdomains_ASD48_RS33295_PKS_KS.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T2PKS: t2clf" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1093: Beta-ketoacyl synthase" /gene_functions="biosynthetic-additional (t2pks) CLF (Score: 550.1; E-value: 6.4e-168)" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125752.1" /locus_tag="ASD48_RS33295" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23710" /product="beta-ketoacyl synthase N-terminal-like domain-containing protein" /protein_id="WP_057605534.1" /sec_met_domain="ketoacyl-synt (E-value: 7.3e-36, bitscore: 119.0, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="t2clf (E-value: 8.8e-141, bitscore: 464.2, seeds: 26, tool: rule-based-clusters)" /transl_table=11 /translation="MSEPLPRAAVTGIGVIAPNGASTETFWKSTREGISVLERVDREGC EDLPLRVAGQVRDFDPSAAIEERFLVQTDRFTHFAMAAADFALDDAQLGRPETDAAPFS VGVVTAAGSGGGEFGQRELQQLWGKGSRYVGPYQSIAWFYAASTGQISIRRGFKGPCSV VAADEAGGLDALAHAARAVRRGTDVIVAGATEAPIAPYSVVCQLGYEELSTVDDPTRAY RPFTSAACGFVPAEGGAMLVVEAEAAARARGARVQAYLAGHAATFTGAARWEESREGLA QAVRQALEEADCAPEEIDVVFADALGVPQADRAEALAIADALGAHGTRVPVTAPKTGIG RGYCAAPLMDAAAAVLAMEHGLIPPTPNVFDICHDLDLVTGRARTAEVRTALVLSRGLM GSNSALVLRHGATDAS" aSDomain complement(35025..36224) /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33295_PKS_KS.1" /domain_subtypes="Iterative-KS" /evalue="2.00E-26" /label="ASD48_RS33295_PKS_KS.1" /locus_tag="ASD48_RS33295" /protein_end="408" /protein_start="8" /score="84.8" /tool="antismash" /translation="AVTGIGVIAPNGASTETFWKSTREGISVLERVDREGCEDLPLRVA GQVRDFDPSAAIEERFLVQTDRFTHFAMAAADFALDDAQLGRPETDAAPFSVGVVTAAG SGGGEFGQRELQQLWGKGSRYVGPYQSIAWFYAASTGQISIRRGFKGPCSVVAADEAGG LDALAHAARAVRRGTDVIVAGATEAPIAPYSVVCQLGYEELSTVDDPTRAYRPFTSAAC GFVPAEGGAMLVVEAEAAARARGARVQAYLAGHAATFTGAARWEESREGLAQAVRQALE EADCAPEEIDVVFADALGVPQADRAEALAIADALGAHGTRVPVTAPKTGIGRGYCAAPL MDAAAAVLAMEHGLIPPTPNVFDICHDLDLVTGRARTAEVRTALVLSRGLMGSNSALVL R" gene complement(36245..37513) /locus_tag="ASD48_RS33300" /old_locus_tag="ASD48_23715" CDS complement(36245..37513) /EC_number="2.3.1.-" /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IEA]" /GO_process="GO:0006633 - fatty acid biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-387). E-value: 1.6e-52. Score: 170.7. Matches aSDomain: nrpspksdomains_ASD48_RS33300_PKS_KS.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T2PKS: t2ks" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_functions="biosynthetic-additional (t2pks) KS (Score: 726.6; E-value: 1.9e-221)" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009189295.1" /locus_tag="ASD48_RS33300" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23715" /product="beta-ketoacyl-[acyl-carrier-protein] synthase family protein" /protein_id="WP_057605536.1" /sec_met_domain="t2ks (E-value: 3e-211, bitscore: 696.8, seeds: 25, tool: rule-based-clusters)" /sec_met_domain="ketoacyl-synt (E-value: 5e-56, bitscore: 185.1, seeds: 77, tool: rule-based-clusters)" /transl_table=11 /translation="MTRRVAVTGIGIVAPGGIGVPAFWNLLADGRTATRAITFFDPAGL RSRIAAECDFDPAAHGLDATDVERCDRYIQFALVAGDEAVRDAGLDLAAENPWRVGVSL GTAVGGTTRLEHDYVAVSHGGQRWDVDHRQAAPHLHRAFTPSTLASTVAERFGARGPVQ TVSTGCTSGLDAVGYAFHTVEEGRADICIAGASDSPISPITMACFDAIKATSSNNDDPA HASRPFDADRDGFVMGEGGAVLVLEELEHARARGAHIYCELGGYATFGNAYHMTGLTSD GLEMARAIEEALDHARLDATAIDYVNAHGSGTKQNDRHETAAVKRVLGTHAYDTPMSSI KSMVGHSLGAIGAIELVACVLALANQVVPPTANYETPDPECDLDYVPRVARERKLASVL SVGSGFGGFQSAVVMNRPREKTR" aSDomain complement(36353..37501) /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS33300_PKS_KS.1" /domain_subtypes="Iterative-KS" /evalue="1.60E-52" /label="ASD48_RS33300_PKS_KS.1" /locus_tag="ASD48_RS33300" /protein_end="387" /protein_start="4" /score="170.7" /tool="antismash" /translation="VAVTGIGIVAPGGIGVPAFWNLLADGRTATRAITFFDPAGLRSRI AAECDFDPAAHGLDATDVERCDRYIQFALVAGDEAVRDAGLDLAAENPWRVGVSLGTAV GGTTRLEHDYVAVSHGGQRWDVDHRQAAPHLHRAFTPSTLASTVAERFGARGPVQTVST GCTSGLDAVGYAFHTVEEGRADICIAGASDSPISPITMACFDAIKATSSNNDDPAHASR PFDADRDGFVMGEGGAVLVLEELEHARARGAHIYCELGGYATFGNAYHMTGLTSDGLEM ARAIEEALDHARLDATAIDYVNAHGSGTKQNDRHETAAVKRVLGTHAYDTPMSSIKSMV GHSLGAIGAIELVACVLALANQVVPPTANYETPDPECDLDYVP" CDS_motif complement(36794..36832) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS33300_0002" /evalue="5.00E-03" /label="PKSI-KS_m4" /locus_tag="ASD48_RS33300" /protein_end="240" /protein_start="227" /score="10.2" /tool="antismash" /translation="FDADRDGFVMGEG" CDS_motif complement(37331..37351) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS33300_0001" /evalue="9.90E+01" /label="PKSI-KS_m4" /locus_tag="ASD48_RS33300" /protein_end="61" /protein_start="54" /score="-3.1" /tool="antismash" /translation="FDPAAHG" gene complement(37510..37929) /locus_tag="ASD48_RS33305" /old_locus_tag="ASD48_23720" CDS complement(37510..37929) /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) MannoseP_isomer" /gene_functions="biosynthetic-additional (t2pks) CYC C5-C18 (Score: 205.7; E-value: 4.6e-64)" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125754.1" /locus_tag="ASD48_RS33305" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23720" /product="cupin domain-containing protein" /protein_id="WP_057605538.1" /sec_met_domain="MannoseP_isomer (E-value: 3.7e-07, bitscore: 25.1, seeds: 17, tool: rule-based-clusters)" /transl_table=11 /translation="MDLSEVEPNTRRGGDLRAMLTPATVGATSGFMGLALIQPGDRIAE HYHPYSEEFVYVVCGQLEVDLDGEPHPLQPEQGLLIPLNVRHRFRNVGKVEARMVFHLG PLAPSPPLGHVDTEETEGEPAVVGAESAARRQVRS" gene complement(38024..39178) /locus_tag="ASD48_RS33310" /old_locus_tag="ASD48_23725" CDS complement(38024..39178) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020113636.1" /locus_tag="ASD48_RS33310" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23725" /product="SchA/CurD-like domain-containing protein" /protein_id="WP_057605539.1" /transl_table=11 /translation="MTTTSERVAGSRARQASQRVSQSVFDGSRLRVVLLVDVYDGAQQQ FLEAYEQLCNQVASVPGHVSDQLCQSIENPSQWLITSEWESAPPFLAWVNSEEHVAMVE PLHSCVRDTRSLRFHVVRETGGPAVAADQAKRRLQTSPRIGDGVIRHALTFTVKPGSEE IVAKILADYASPEPQVDDTTRLCRTSLFMHGNRVVRAIEVRGDLLSALRHVSRQPEVRA VEEAINPHLEQDRDLNDPESARVFFTRAALPAVHHVTAEERQNPQAERYALYYPARPDR GMKLAELLARQDEAAADDPRSPVLRSTIFQRDDVVVRLIDVRGGLETADPVQALGLSDP GQVAELTTLQDDAAGKSASKDGRLARFLELARMDLVTDRRSPDA" gene complement(39316..39957) /locus_tag="ASD48_RS33315" /old_locus_tag="ASD48_23730" CDS complement(39316..39957) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125756.1" /locus_tag="ASD48_RS33315" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23730" /product="class F sortase" /protein_id="WP_057605615.1" /transl_table=11 /translation="MVCAAVAVVLALNLFGGGNDPATGAGSPPHAPPAAGSVPAARAPD APAPAAGEADTGDAVGKHLPRSRPVRLFIPKIGVDAPFVDLAIGPTGQLEPPPANDVNL VGWHAKGASPGETGTAIIAGHVDTKTSPAVFAGLSALVKGDGFQVLRADGVKASFRVDS VETFDKADFPSERVYGDTSEAQVRLITCAGAYDRRVKDYTDNLVVFAHLV" CDS complement(40179..>40416) /GO_component="GO:0009986 - cell surface [Evidence IEA]" /codon_start=3 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125763.1" /locus_tag="ASD48_RS33320" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_23735" /product="LPXTG cell wall anchor domain-containing protein" /protein_id="WP_157880756.1" /transl_table=11 /translation="ETYKDKDDNGGEHGKDSWNGGKEESGGWSKEHYKPSGGVHTGGGA LATPSATAAGLGVLGVAGAGLYALRRKKTAGSVA" gene complement(40179..>40420) /locus_tag="ASD48_RS33320" /old_locus_tag="ASD48_23735" ORIGIN 1 aactggacgt gttcgcgtac ggacgccggg atccccatcg ccaccggccc acgccactcc 61 tccagcgcca ggacgaactg ccgggccgcc gtcccgggcc gtccggtggc cgccgcccgc 121 ttgccctgcc gggtcagctc acggaagcgc agcaggtcga cctcgtcggt cgccgcctcc 181 aggaggtagc cgccggtccg gcgcagcaga cgccggcccg ggacgcgggg cggcaacccc 241 ggttcgagca gccgccgcaa cgcgccgacg tagcgccgca ccacgttcag cgcgctggcg 301 ggcggccgct cggcccacag cacgtcgacg atctcgctgg tcggcacgga ccggccggca 361 tgcgccagga gcagggccag cagggcgcgt tgctggggga agccggggtc gagttcccgc 421 ccctcccgcc acagccgtac cggccccagc atctcgaagc gcgtcacctc gcccaaggcg 481 tggtccggcg gctcacccaa ggcgtggtcc ggcggcgtga tcgagccgga gcggggtgtc 541 agacggcacc ggcgtgaccg tcccgtgcgt tcagcagtgc ctcgacccgc tcggcgtcgg 601 ggtggttcag tcccctgaga aggaccagcg cccgctgcca cgcgatgcgg gcgccgtcgt 661 ggtcgccggt ggcgaggtgg gtgtcgccga cccggacgag gatgtcggcc tccacgtagg 721 gcacgcccag gtcgcgcagc agagcgaggg cgttgcggta gccgaggagc gcgtgcgggt 781 ggcggccgag atggtggtgg gcgtaggcga tgctgtccca ggtggccgcc tgcccgtagc 841 ggtccccgag ttcctggagc atggcgaggg cctcgaagca gtgcgtcagg gcacgccggt 901 gctcgccgag ccgggcgtgg taccagccga ccgagttcag cacactggcc tgcgcggcgc 961 ggtcgccgag cgtacggaac aggccgaggg cgaaccggtt gtggcgcagg gcgccgggca 1021 ggtcgccctg ctggtcgcac tcccagccga gactgcggtg ggtgtgggcg cggcccgtgt 1081 cgtcgcccag ctcggtgaag agctccaggg cccgctccag tcggggaacg gaccgggagt 1141 gcagaccgag ccggccctcc acccgggcca gtccgcgcag gccgcgggcc tccaacgcgg 1201 ggtcggcgag ccgtcgggcg gcgtccagcg cggtgcgctg cacggcgagc ccgtcgtgcc 1261 agtgaccacg ccggtcgaag aacggctcca gggaccaggc cagttggcag gcgagacgtt 1321 cctgcaccgg tcgacccgac gcggcggccg tctcgaccac ggcgagcagg accgcgtgtt 1381 cggcggtgag ccaggccagg gcgcggtcgt cgtcggcgag gggttccgga tgcacgccct 1441 cgggcgcggg cggcgggggc aacgggtcgg cgttgggggc cagcagccgg tccgcggcgt 1501 gggcggtgtg caggtagtga tggtgcagcc ggttgagggc cgccgcacgc tcggcctcgg 1561 tgtgccgctc gtggacgagt tcgccggcgt gggcgcggag caggtcgtgg aaggcgtagc 1621 ggccgggact gtgttcggtg acgaggtgca gtccggtcag ctcggccagc agcggtcggg 1681 tcacgcgtac gggcaggccc gccagggcgg ccgcggccgg cagggagagg tcggggccgg 1741 ggtgcagcgc gagcagccgg aagagccggg cggccgccgc cgagatcgcg cgcgaggacc 1801 aggagaagac cgtgccgacg tccacggagg cgtcggagcg ggcgaaggcg tcgaggctgc 1861 cgtgggcctc gcgcagttcg gcggcgacgg cggcgagcgg gaagtggggg tgagcggcgg 1921 cgcgggcggc gacgcaggcg agggcgaggg gcagtccggc gcacagcgcg ctgatctcgt 1981 cggccgcccg gggctcggcc gcgacccgtt ccgcccccag ccggcggacc aggaaggacc 2041 gcgcctggac ggcgtcgaac gggcgcagga ccagggagtg ggcaccgtgg gcggcgacga 2101 gcccggtcag ttcgtcgcgg ctggtgacga tggcgaggca gccgggcgag ccgggcagca 2161 gcagccgcac ctgctcggtg tcccgcgcgt tgtccagcac cacgaggacc cgtcggccgg 2221 cgagcacgct gcggtacagg gccgcctgcg cgtccacccc gtgcgggacg cgttccggtg 2281 gcactccgag cgcaccgagg aaaccccgga ccgcctcccc cgggtccagg acggcgccgg 2341 acgggtcgaa gccgcgcagg ttgacgtaga gctgcccgtc ggggaaccgg tcggcgacgc 2401 ggtgggccca gtgcaccgcg agcgtggtct tgccgacgcc cgccataccg ccgatggcgc 2461 tgatcaccac ggtcccgggc cccgccccgt ccgctccgga cagcgcgaac acctcgtcga 2521 gctcgacgtc ccgaccggtg aacgccgtga tgtcgtgcgg cagttgggca ggcgacggaa 2581 gggcggacgg cgacggcgga tccggcaccg gcgcaggcgc gggcgcgggc gcgacagaat 2641 cgtccgcgcc cgcgcgatcc ggcacctcac cactccgcgg cgcgggcgcg gggaacccgt 2701 ccgtgcccgc gccgccggac gcctcggcac tcgacccacc ggacggcccg accgccgtct 2761 cccgcatccc ggacagaacc gtgtcccgcg cgtcgcgcag ttccgctcct ggatcgatcc 2821 ccagttcctc ggccagccgc gcccgtacgg cctcgtaggc ggcgagcgcc tccggacggt 2881 gtccggccgc cgccagcgcg aggagcagcc ccgcctggag gggttcgtcc aacgggtgtc 2941 gcgcggcggc ctgtcgcagc tcggccagga ccgcgtccgg tcttccggcg cgcagcgcga 3001 cgtccgccgc ctgccgtacg gctgcgggca gttcacggtc caccgcgtcg aacgccgggt 3061 gcgcacgggc ctgcacggga acgccgccgg cgagggggcc acgccacagc gacagtgcct 3121 cggtgaggag ttcgagcgcc tgcccgggtg agcggtccgc gatccggcgc ccctcctcgc 3181 gcagtgcgcg gaacctcagc aggtcggagg agtcaccgtc ggtcacgagc cggtatccac 3241 cggcgtcccg caccagccag cgcccctccg cacgggcggc gaggccgggt tccagcagtc 3301 ggcgcagcga acccacatgg cgccggacga cattgaccgc gctgcgcggt ggagccgctc 3361 cccatagcac gtcgacgatc tcgcccaccg cgaccggccg ccccgccccg accagcagca 3421 gggccaggaa ggcacgttcc tgcggtcctc cgagctccag ttccgcatcc ccccggaaca 3481 cccgaacagc gcccaggacc gcgaaccgca gtggctccgg cggcacgcca tcccctccct 3541 ccggtcgtcc tccccgcctt cgactgtacg acaggacaaa ggttacccag agttacacag 3601 gatgcgttcc ggctgttcag ggacggcacc ccgaagaaaa cctggttgag ctagcctaaa 3661 acctagggat actaggaaac gcggcgaggg cacgagggcc ttcacccgca cggacaaccg 3721 actggagcaa gccatgaccc cgccccggac cggcaccctg gcagtgcccg gcgccaccct 3781 gtactacgag accctcggca gcggaccggt cctgctgctc atccccggcg gcgccgcgga 3841 cgccggactg tacgcgggca tggcaccgga gctggccacc cgctacacgg tcgtctcgta 3901 cgaccctcgt ggtctgtccc gcagccctct cgacggcccg gcggacacct cgcgcgccga 3961 cgaagaggtg tcggtgtgga gcgacgacgc ccaccggctg ctcgaactgc tctcccccga 4021 cgaggaggcg gtcgtcctcg gttgcagctc cggcgccgtc gtcgcggtgg agctgctcgc 4081 ccggcacccc gagcggctgc gccgggtggt cgcgcacgaa ccgccgctgt tgcggctgct 4141 ggcggacccc gccccgcatc gagcgctgtt cgccgaagta cgcgagacct tccgcaccga 4201 gggcgccgac gcggccatga tccggctcgg tgagggactg gcggacggga cggaccggcg 4261 ggctcccgcg cggcccacgg agctgccgcc cgagatccgg gagacggccg accggatgca 4321 cgccaacctg ccggtcttcc tgggccgtgt cttgtgcccg ttctcctcgg ccgcaccgga 4381 tctcgccgcg ctgcggcccg tggcacacaa gctggtgccg gccgccgggc gcgactcccg 4441 ccgccaactc cctttgtacg gaccggccgc gcgcctcgcg gagcttctgg gacgcggact 4501 cgtcgagttc ccgggcggcc acctcggagc cgtcgagtcc ccgaaggagt tcgccgaccg 4561 tctgctgacc gtcctggacc ggtcggcccg gtgacggcgc gccggccctc accgggccgg 4621 cggacggaca agcggggtcc gggacgacct cgccccggac cccgtcagac cgtggagtga 4681 gtgaccgctc gtcagcaggt gcggccggtg tagtaggcgc cctggatctt ggccgcggag 4741 cccagccacg acgtgccggg accgacgcac cgctcgtagt cggcggccca ggccacgtcg 4801 accttgatga cgacccgtga gccgtccgac gtgcagtggt tgtagaaggc gtcggaaccg 4861 gtctcgtaga agccgcacgg gtccgcggcc gcggggcccg cggtggcggc cgtcagcgca 4921 cccagggagg tgaggacgag agcgacggaa ccgagggtgc tgagcaccga acgacgaaca 4981 cgcacagcgt gactccttgc cggaaacgag gatcgacaga ggcaaaagcc caggtccggc 5041 gagggaccgg aggcctgcac caggatcgtg gcgggctccc gcagatgatc gaacgacggg 5101 ccccgttcac cccgcgaatc gtttcgccgc tactccgtcg gagtgatcat cgccgcaagg 5161 acgcgtgagc ggggcggggt ccccgggatg gagggccgtt tcacccgggt gagcgccttg 5221 agtggtggag cggcgctcgc tgactgacgg tggatcacgt caggccgggt cgtgtcagct 5281 gacgatgtgt cggctgcccg gtcgagacgg aaggaccatc agatgcgttc tgctcgcatg 5341 atcctggcca ccgcggcggc ctcggccgcc ctcgnagctg acgatgtgtc ggctgcccgg 5401 tcgagacgga aggaccatca gatgcgttct gctcgcatga tcctggccac cgcggcggcc 5461 tcggccgccc tcgccatcgg cgcccccggc gcctacgccg gtgacacgga ccacgacgac 5521 tcttcctaca gcaaggagga cagctcctcg tacggcaagg agcacggcaa ggaggacgac 5581 tcctcctacg gcaaggagga gcacggcaag gaggagcacg gcaaggagca cggcaaggag 5641 gagcacgact ccccgcacgg cggcatgcac accggcggcg gcgcgctcgc cctggccgac 5701 gacagcagcg accgcggcgc ggccaaggac cccaagtacg accccgagac gtacaaggac 5761 aaggacgaca acggcggtga gcacggcaag gactcctgga acggcggcaa ggaggagtcc 5821 ggcggctgga gcaaggagca cnccgagacg tacaaggaca aggacgacaa cggcggtgag 5881 cacggcaagg actcctggaa cggcggcaag gaggagtccg gcggctggag caaggagcac 5941 nacaagccca gcggcggcgt gcacaccggn ggcggcgccc tcgccacccc ctccgcgacc 6001 gcggccggac tcggcgtcct cggcgtcgcc ggcgccggcc tctacgccct gcgccgcaag 6061 aagacggtgg ggggtgtggc ctgacccatg cctgacgcga tagcgaagcc gcggccgcca 6121 cacatgcccc cctgtggcgg cccggcccgt ttttgcaccg accgtccttc ttcggccgag 6181 ccactcccgg ccgggatcgt atgcaggagc ccctacgccc ctgtcggccc gtccgcttcg 6241 cccgtacact gacaatttgt agacgtgcgg gcgcagttga ccggggggga gccgccatgt 6301 cgggggacca gtacggcaga tacaacgaca ccgaccacaa caccttctac tacgttccgc 6361 ccatgccgtc ggctccgccg cctgcgccgg cggacggcgc tcgggccgtc gcggtggccg 6421 tgctcaacct cagcggtctg ggcctgggtt acgcgctggt gcgccgctgg gccctgatgg 6481 cgctgtgctg ggtcgccacc gccgtcctgc tcttcgtggc cctgccggcc gacccggacg 6541 gtgtcccggg attcgccctc gtcctgtacg tcctgttcct cgtcgcggtg gcggcggacg 6601 gcgcgcgcgt gggcctgcgc aaccggctgt cgggactccg gcgggcgccg ctcgcgctcg 6661 tgctcggact gctgctgctc gtcgtgccgg ccgggggtgt cgtgctgtac gacagcgcac 6721 gggacgaagc gacccagcag atgctgctcg accggctcga cgaggccgac gaactggtgc 6781 aggccgccgg tgacaagccg ttcaactcgg cccaggccga ctaccgcaag gcgctgggcg 6841 tctacgcgga cctcaggtcc gaccaccccg gttcacgggc ggccgagcgg gtgcccgccc 6901 ggatgaagac ctactacacg acggtcggag ccgcgtacgc acagggcgac tactgcgagg 6961 cggtcgagcc gctgaagtac ctgcgcacgg tcccgaagag cctgcccggg acggacctcg 7021 gggcactgaa gacctggccc gacgaccggc tggccacctc gctgtacgag tgcgcgtcga 7081 cggccctcac cgcgggcgag gccaactggg cctcgcagta cggggaactg ctgaccacct 7141 tccccgagtc ggagcaggcc gcgaaggtcg aacccgccgt ggccgccgcc gtcgtccgta 7201 cggagaagga cctgcgcggg gccgaaccct gctccgcggt ccagcggctg cgcacgctcg 7261 gctcccagat cgacggtctg gagtccgggc aggcggccat cggcgccgct ctcgacaagg 7321 acggccggcg ggccacgacc agcgccgaca ccggcaccta cacctgcggc gtggaccagt 7381 accgggacgg cgacttcgag tcggcgcgga cgaccatgac ggagtacgcc tccgcccaca 7441 agaccgccaa gaacgccggc ctggcgaaga agatcgccat agcggcggag atcgcccaga 7501 cggtgccggc cgcgggcaag aagctgccga cgacccgtac cggcggcagc atctcggtca 7561 ccgtgcagaa cgacagcccc gacgcggtca cggtcctctt cacgggcccg gtcaccggca 7621 gcttcaccct caaggcctgc ggcagctgca aggcgtactc cctcgggagc accatcaacc 7681 cgtcgttcga gccgtgcaac gacagcggca agaactaccc gcagcgcacc atcagcctgc 7741 cggtcggcac cacgtacttc ctgcacaagc cgaacggcga cagctccgcc acgcccgcct 7801 cggacacggc caagctcgag tcgggctaca tctacacgga gtgcgcctac acgacgcaga 7861 gcctggggac aggcctctga attccgtgtg aaaacccgga ggatttccgc ccgctgaaag 7921 gctgtcaaca gcgcaccgtg ttacctgtgg gtcgcatgtg acgggtgata aggtgcgccg 7981 gaattctctc gcgcagggcc cccacacgaa agccttgaga tactccatga acgacataaa 8041 ggcggaaacg cccgtgcatt cctttgcccc gggcggtcga cgccggcacc gcaaggccag 8101 gcagagcggt accggcgtcc ggcgggcgat ggtgctcgcg ctggccctgc ccgtcacctc 8161 ggcggccctg gccggcccct cggcgttcgc cgccgaaaag ggcatcggca cgacggccga 8221 ggacacggcg gcgggccgga cgctcgacgc ggacgaccgg cagatggtcg ccaacctcga 8281 gagccgcgtc ctcgaccggc gcctggggtc cgaggtcagc ggtgtggtcc tggactccgc 8341 gtcggacacc accctgtggg accacaacgg ggcgaccgcg ctgatgccgg cgtccaacac 8401 caagctcgcc acggcgaccg ccgcgctgac cgtgctcggc ccgaaccaca cgttcaccac 8461 gaaggtcgtc tacggcaacg gcaccctgac cctggtcggc ggcggcgacc gtacgctgac 8521 cggcgccgac ctcgccgaac tggcgaagaa cgcggtcgcc gggctcaagg cggcggggct 8581 gacgtcggtg agggtcgccg tggacgacag cctcttcggc gccccgaccc tggccaacgg 8641 ctggaacacc ggctactacc ccgactccgt cgcccccgtg cgcgcactgg tcgtcgacgg 8701 gcacggggtc caggacacct cgctcgacgc cggacaggtc ttcgcccagc agctcacggc 8761 ggccggggtc gccgtcgacg gcgccgtcac ccgcgccgag gcgagcccgg gcgacgtacc 8821 ggtggcacgg caccggtcgg cggcgctgtc ggagatcgtc cacaagatga tcaaggtcag 8881 cgacaacaac atcgccgaga ccctgctgcg gatgaccgca ctcggggcgg gccgcccggc 8941 caccttcgag gacggcacgg acgtcgtgcg caaggtactg agcctccgtt acggcgtttc 9001 cctcgacaat ttcgagatct acgacggaag cggcctttcg cgggccaatc gcattccggc 9061 cgccacgctc gcggaaatcc tcgaactgct gacggaatcg cgctactccc ccaccctggg 9121 ctccatcctc gacgggctgc ccgtctccgg tgaggccggc agcacgctcg gtccggaatg 9181 gggccgcttc gacgacgtga actccatgtg cgcggtgggc aaggtgcacg cgaagaccgg 9241 caccctcacc ggcgccatcg ccctgagcgg tctgacccag ggcaaggacg gcaagtggaa 9301 ggtcttctcg ttcatcgaga acaactccac ggccaacccg aacgacatca aggacgccat 9361 ggacggcctc gcggccaccg tgaacggctg ctgggcgtag cgaagacccc tgcgcgacga 9421 gagggccggc tcctgcgggg gccggccctt ctcgcttcgc gtcgcgaccc tccggtgggt 9481 gtgacccaga ccacaagaaa acgctgccgt ttcgatggct ccgagggcta gtctgggcag 9541 caagtgaacg aaacagtttc gttcatgaga ggcgcacgcc cccactcgca tggagaacac 9601 agccatggcc tccgtactca tcgcccacga ccagtccctt caacgtgtcg gcctgcgcat 9661 gctgctgacc gccgagcccg atctgagcgt cgtgggcgac acggcgagcg ggcccgaagc 9721 ggtccggatg agcgccgcgc tgcgtcccga cgtcgtcctg ctcggcggcc accgtcccgc 9781 gacggacgac atcgagacca tccgccgcat cgcccacccg ccacacctca ccgccgtcag 9841 cggccccgcc ggaccgctcg gccagcagcc gcggatcctg gtgctgacct ccaccggcga 9901 cgaggggtac gcctacgccg ccctgcgcgc cggcgccggc gggttcctcc cgaaggacgc 9961 cacaccccac gaactgaccg cggccatccg cgtcgtggcg gccggcgacg ccgtcatcac 10021 ccccgagctg acccgcgcgc tcatcgacac cgtccgccac gagcgcgccc cgcgccccgg 10081 cgagcgggcc gtcgggctcg acaccttcac cgggcgcgag cgcgacgtcc tcgtcgccgt 10141 cgcctccggc tggtccaacg cggagatcgc cgcacggctg tccatcgccc cgaccaccgt 10201 gaagtcgcac gtcagccaca tcctggccaa gatcggcgcc cgcgcccggg tccaggcggt 10261 cgccttcgcc tacgagtacg gcctggtaca cccggcggcc tgacgcccct ccgcgcccca 10321 tgtgcctggg cacctcccgc gcggccccgt accccgcctt ccgggtacgg ggccgccggg 10381 cggctagccg cggtcgcgct ggtggacgcg tgccaggagc aggttcgggt cgggctgctt 10441 gaagtaggcg gcgctcggga cgtaggcggt ccggccgcgt acggccaccg aggtggggtt 10501 ggcgaggccg tccttcttgg tgaggacgat ccggtgggtg ccgtcccgct ggacctgggc 10561 gatctcgctg ccgccgatca gggcggcgag aaccgtgtca cggtgccggt ccacgaacgc 10621 gaagtcgtcg atcgcgaaga ggctcttcgc ccgggtctcg atcgcgccgg cacagccgct 10681 ctcacggacg gggatgcgca gcagcgtccc ggcgttggtg ttggacaccc acacggcgtc 10741 gcggtggatc ttgaggccgt tgactccgac gcgggccgcg ggcggtgcgt tgagaggctc 10801 gagcagggct ccctcggccc atgccgtggg cttgccgccc gagcggggca cgcgccagac 10861 ggtgcccagc accgagtccg cgacgtagag cacgccccgg cgctcgtcga gggcgaggcc 10921 gttggggaac ccgctcggcg gcagctgtgc gatctgccgg ggcctgccgc cgccggaggg 10981 gatgcgccag atgccggtcg cgcgggtacc ggtcgcgtag ttgacgtaca gggtgccgtc 11041 ctgtgcgcgg gcgatgccga ggacgacggc cctgccgacg acgggtgtct gcgggttcgt 11101 cacggcgggc agggtcgcga ggatccgcgt cctgccctgc cgggtgacgt tgacgacctg 11161 ccgggcgctg gagaacgtca ggtcggcgga gccgtcgggt tcgagggcga tgttctccgg 11221 tgactggccc ttggcgaggt cgaagtgggc gaccacgcgc ggagcggaga ccgtcggctc 11281 gtctccgacg gcgggagccg tggcgagcag gccgagggcg agggtggcgg cggtgacgcc 11341 cgccgaacgg gggactcggg gcatgtgacc tactttgcag ggaagccgga acgccgccgt 11401 gcggcggcca gacgaccatg gccgtgggcc ggcggcggtc gccgcagtcg tggccggggg 11461 atcgcccgcg tggcccacgg catcgacccg cctgccgctc acccgggtga tccggccatg 11521 ccgcagactg tgcggtgcgg acagcggtcc cgacccccgt cccgacggca gcccgcccga 11581 cggacactca cccggaagga agcacagcgt gatcatcttc ggcaccaagg gatacctcta 11641 ccagctggcg atactgacgc tcgtctgcgg ccgttgcggc aatcccgccg cgcacacgct 11701 gcgcaagcgg gtcacgaagt tcaccctgtt cttcgtgccg ctgttcccga tctcgacgag 11761 tcacgcgacg cagtgcacgt tctgcggtgc cgagcagaag ctgaccaagg agcaggcgga 11821 gcagttgacg gcgcaggccg cgggcggcgt cggcggccag gcgtacggac agccgcacca 11881 gcagccgcac cagcactgac ggcctcccgc ggctcagcgg gtgaggcccg ccctcgcgca 11941 ggcggtcagg agctcacgcg tgcagatctg cgccgtggtg tacaggccgc ccttgaccag 12001 ggtccgctcg atgtcacggg ccgtcaccgg acgcggctgg agcaggacgg ccgggacgcg 12061 tttggtggtg gggctgtcga cggtcgtggt ggcggtgtcc cgggggtcct caccccggcc 12121 gacggcgacg gccatggcgg cgaccgcggc ggcctccttc gcgaacggct tgtagaccgt 12181 catgtactgc tcgcccttga cgacgcgccg caccgcgtcg aggtcggcgt cctggccggt 12241 gacgggcggg agctcggtga cgccggctct cttgagcgcc gcgacgacgc ccgcggcgat 12301 gttgtcgttg gccgcgagga ctgcgtcgat ccggtcgggg ccgagggccg cgatggcggc 12361 ggacatgttg gtgtgggcgt tctgggtgct ccagtccgcg gtgttgtagg accgggcgat 12421 ccgcacctcg ccgctgagga cggacagcgc gcccttccga taggactccg cgttcgggct 12481 ggtcggatcg ccgttcatca tgacgacgtc gtcgctcgcg gcccgttgcc ccggtttcag 12541 gcccaaggcc ttcaggagcg cctcgccctg gagtctgccg accatgacgc cgtcgaagcc 12601 gacatagccg gtgatcggac cctcggcgag gcggtcgtag gcgatcaccg ggacacccgc 12661 ccggtccgcc tcctggatgg aggagcgcag cgcccgggtg tcggcggcgt cgaggatcag 12721 gacccgggcc cccttggtga ccatggagat catctgctgc cgctgtcgcg tgacatcgct 12781 ctcggcgttg gcgtattccg tccggcagcc ggggcagagc ttcctgacct gcgcctcgat 12841 cagcggccgg tccgcgtgtt cccagcgcgg gaccatgcgg ctcggcagca gcaggccgac 12901 ggtgaaccct tcgccggccg ccttctcgtc tcccccgcag gcggccaggg gcatcgtcag 12961 gagcgccgcg gcgagcaccg cgacgacagc cctgcggcgt gtcctcacgg cactccctcc 13021 ggcacggcga tctcgctcca cacctgtttg ccgccggcca ccgggaccga cccgaaggcg 13081 tccgacatcg cctcgaccag cagcagcccc cggccgccgg tcgcctccca gtcgacgatc 13141 accggtttgg cgggcgcgcg cggcgaggag tcgctcacgg agacgcgcac ccggtccccg 13201 cgcagcacca ggtcgagccg gaccggcccc tgggtgtgca ccagcgcgtt ggtgacgagt 13261 tcggagacga ccagcagcac cgcgtcggcc gcctcctgga ccttccagcg gcgcagggtg 13321 cgcgcggtga agcggcgggc gtgcatgacg gcgtccggca ggcgccacac catccagccg 13381 gcccggatcg gccgggtcgt catgccgtcg tagcgcagca gcagcagcgc cacgtcgtcc 13441 tcccggcggc cgtcgtcgcc gaggagttcg tcggccatct tccccgggtc ggcggggtcg 13501 gccgcggcga gcgcgacgcg tgtccggcgc atgccctcgt ccaggggcag gtcggcggcc 13561 tcgaccaggc cgtcggtgac cagggcgagg accgtgccgg gggccagttc gacggacgtc 13621 atggggaagt ccgcctccgc caggacgccg agcggggggc cgcccgccac ctcgacctcc 13681 tcggtggagc cgtcgggcag acgcagcatg ggtgccaggt gcccggcccg gacgaagagg 13741 acgttgccct cctccaggtc cagttcggcg tagcagcagg tggcgaacag gtcggtctcc 13801 atgccgacga gcagccggtt ggcgtgcgag acgaccacgt cgggcgggtg cccctcgatg 13861 gcgtaggccc ggacggccgt acgcatctgg cccatgatcg tcgcggctcc ggcgctgtgc 13921 ccctggacgt cgccgatgac cagggccacc cggtcctggg agagggcgat gacgtcgtac 13981 cagtcgccgc ccacctggag cccgcgccgg gcgggcagat agcgggcgac ggcggtcccg 14041 ccgggcagtt cgggcaggcg ccggggcagc aggctgcgct ggagcatcgt cgcgagttcc 14101 tgctcggcgt cgtgcgcgtg ggcgcgcttg agtgcctggc cgaccagggc ggcggtggcg 14161 gtgagcaggg accgctcctc ggggacgaac tcgtgcggcc ggtcccagcc gaccaggcac 14221 accccggcga cctggccctt ggcgggcagc ggcagcacgg ccagtccccc ggctccgatg 14281 ccggccagcc cggcttcgag cggggtgccg gcgggccaga ggtccatccg gccgtcccgc 14341 agggccgcct ggagggtggg cagggcgcgc agcggtgcgt cgggccattc cgtgcgccac 14401 tcggtgcgcc acacctccgg ccaggcgccg ggctggggcg ggtcgagggc ggtgaccatg 14461 acccggtcgt cctggaccgc ggcgagggcc acgtggtcgg cggccagcgg ctcgcgcagg 14521 gcggcgacca ccacgcggcc gacgtcgcgg accgtcgcgg cgtcgtcgag ggcggcggtc 14581 agccactgga tcctggagac gtcgtcgccg ccgcggcgca gcaccggggt ggccgtcacc 14641 acgcccagga cctgcgcggg cccgtcgccc gtgcccggct ccgcccggca gctcaggctc 14701 agccagcgca tctcgccggt ggggccccgg acccggaact ccaggtcccg gcggccgaag 14761 gcgtcggtgg tcggctccag gacggacatc agggcgtgca tgtcctccgg gagggcgtgc 14821 gcgagcaggg tgtcgacctt gccgtcgaag tcgtccggtg tgatgccgac cagttcgagc 14881 agggtgtcgt cggcctcgat caggccggtg tccggggcga ggacgaagga gccgacgcgc 14941 aggctgcgca gggcggggcc cagcagcggt gtcggcatcg gcgggtcggc gcccggcggg 15001 aggagggccg cgaccgcgtc ggcgtaccgc tccaggaagc ggcgctgctc ggcctcgaag 15061 ccctccggcg aggctcccag gacgaggagg cagcccagtc ggctgccctg gatgccgagg 15121 ggcagcgcgc cgagcggggt cccggcggtc agccacaggg ggtggtcggt gcggaaggcg 15181 cgtgccgcgg gcgagtcacc ggacagcggc aggcgctccg gcggtgacgg cccggaggag 15241 acgcttccgg acgtgtccac cagctgaagc tcgcgtgtgc cgacctccgg cgcgtagacc 15301 gccgccagtg tcgctccggc gaaggtcagg gcccggtcga ggcatgtccg caacgtacct 15361 cccatcctgc cgcaggtgcc gacaggttga gatcggggca cccacccacc agaatcgcat 15421 ataaggatca accgaacata tccaccgcta cccaccctat tgtcgtctac ggcaggtacc 15481 acccatgaag gcctgcatca gggacacagc cgccgcggtg accgcggtct ccaccgcgat 15541 cgtcctgacg gcctgcgggg cggactcccc cgacgaaccc ggcaccgaca ggagccggca 15601 gcgcatcggt ctgctgctgc cggacgtcac cacgccccgc tgggagaccc aggacaggcc 15661 actgctggag aagaagatcc acgaactgtg ccccgactgc gcggtcgaac acgccaacgc 15721 caagggcgac gtggccctcc agcaggaaca gatggactcg atgatcacca agggggtcga 15781 tgccatcgtg ctcgtggccg tggacgcccg ctcgctcggc ccggcggtca ccaaggccca 15841 cgaggcggac atccccgtca tctcctacga ccggctctcc gagggcccca tctcgggcta 15901 cgtctccttc gacggcaagg aggtcggcag gctccagggc cgggcgctgc tgacggcgat 15961 gggcgacaag gtgcccggcg ccgagatcgt catgatgaac ggcgacccca gcgacccgaa 16021 caccaagtcg ttccaggacg gcgccctgtc cgtgctcgag ggaaaggtga agatcggcaa 16081 ggcctacgac accctccagt ggcgcaggga ggccgcgcac atgaacatgt ccggggccat 16141 cgcggccctc ggcgtcgagt cgatcgacgg ggtctacgcg gccaacgacg gcctcgccgc 16201 cgggagcatc tccgccctca aggcgaacaa ggtcgacccg ctgcccccgg tcaccgggca 16261 ggacgccgag ctctcggccc tgcggcgcat cgtcggcggc gaccagtaca tgaccgtctt 16321 caagcccttc ggccccgagg ccgccgccgg cggcgccatg gcggtcgccg cggtccgggg 16381 ggagagtctc gggcaggtgg ccacggccga ggtgccgacg cgcggcgggg aagcggtcgc 16441 cgccgtactg ctcacgcccg tgtcggtgac cgtcgacaac atcgaggaca cggtggtgaa 16501 ggacggcctg cacaccgtcc ggcagatctg cacgccgcag ctccgggccg cctgcgagcg 16561 ggccggactg acctgacccg catcgaacgg acaccgtgtc ggcaggacac gcggcgatcc 16621 gacgccgccg ccggagccga cgccctcggg aaggagatgg tttccgtgcc ggagactcgc 16681 tccgggcgtt ccgccgccct gctcgggggc gatgcgcccg gggccgtcac cggcgccgca 16741 ccgggcacgc ccgcacggcc ggccgtggcg gaggcgaggt ggtgacccgc gtgcgggccg 16801 ccgcccgtgc cgtgcggagc gggcccgcgg tcctgcggcg caggctgagc gccggtgaac 16861 tgggctcact gcccgtcgtc ctcgtcctcg ccgtcgtctg gatcaccttc cagtccctca 16921 acgagaactt cctctcgccc cgcaacctgt ccaacctcag cgtggacatc gtgggcaccg 16981 ggatgatcgc ggtcggcatc gtcttcgtgc tgctgctcgg tgaactcgat ctgtccgtcg 17041 gctcgatcag cgggctcgcg gcggccgtct tcgccgtgct gaacgtgaac aacggggtgc 17101 cggagtggct cgcgctcatc gtcgcggtgc tggcgggcac cgtggcggga accgtccagg 17161 gctactccat cgccagaacc agggtgccgg ccttcgtggt cactctcgcc gggctgctca 17221 cctggaacgg cctgatgctc tccgtcctcg gggacagcgg caccgtcaac ctcgacgaga 17281 acgggctcgt cgccaagctg accagctact acttcaccga cgacgccgtg gcctacggcc 17341 tggcggcggt cgccgcgggc gcggtcttcc tcgtctgcga ccgcgaccgg cggcgccgca 17401 gggccatcgg tatgccgcac cggtcggcgc gcgccatcgc gctgcgcacc gcggcggtcg 17461 ccgtggtcgc cttcggcgtc gcgtacctgc tcaaccggtt ccaggggctg ccgctcgccc 17521 tgctgatctt cctcgtggtg gtggccggtc tcgacgtggt gctccgccgc accccctacg 17581 gacggcaggt ctacgcgctc ggcggcagcg tcgaggcggc ccgccgcgcc agcctcagcg 17641 tgacgtgggt gcagaccgcg gtgctcgcgg cctcgggcac gatggccgcc gtcggcggcc 17701 tgttcctggc ctcgcgcatc acctcggtga gccagagctc ggggtcgggc gtgctgctgg 17761 tcaacgccat cgcggcagcc gtcatcggcg gcaccagcct gttcggcggg cgcgggtcga 17821 cctggtcggc ggtgctcggc atgctggtca tccagtcgat cgcctccggc atggccatca 17881 cggacactcc cccggccgtg cagttcgtca tcaccggcgg ggtgctcttc gccgcggtga 17941 tcatcgactc gctgtcgcgg cattcccagg ccacccgcag acgggcgtga ggggacgttc 18001 gtggaacggt cccggtgacc gttccacgaa cggggggtca ccgaatctgc tcgtcctcga 18061 cgaacgccgc gatcaggccg tggggcgcga ggtcgccgaa catcagctcg tgcagccggg 18121 tgccgtcggc ggcggcctcg gcgctgcggg ggaacatggc ccgctcgtac gcggtgagcg 18181 ccgcctcgac gtcgtcgggg tgcgcggcga gggccctgcc gagttcggcg ccgtcgtaca 18241 tggccaggtt ggcgccttcg ccgttgggga ccgagaggtg ggcggcgtca ccgaggaggg 18301 tcacccccgg cacccggtcc caccggtgct cgatcggcag cgcgtgcagg gggcgcagga 18361 ccggcgcggt gtcggcgtcg gtgatcaggg cggtgagttc cggcgcccag ccctcgtacg 18421 cctgggcgat ccgcgcaccg gctccggcgg cgtcggtgaa gtcgacggcg gcgaaccagt 18481 cctgcggctc gctgagcatc gcgtagacgt gcagggtgtc gcccttctcc cggtgcgcca 18541 cgattcccct gcccggggcg agcgcgagca gggacccgcc gccgaccgcc ttcgcgcggt 18601 cggggtggcg ggtgtcgccg tcgaacaggt acatctcgac gaccgacatg ccggtgtacg 18661 cgggcgaggc ggcacagagc agcggccgga cccgcgacca cgcgccgtcc gcgccgacga 18721 gcaggctcgt gacgacggtg ccgccgtcgg cgaaggtcac ctcgtgacgt ccctcgccga 18781 gggcacggac cccgctgacc ttgtggcccc accggacggt gccggccggg agcgagtcga 18841 gcagcagccg ccgcagctcg ccgcgctgca cctcggggcg gccgcccgtg ccgtcgtcgg 18901 ggtcctcgaa caggacggtc ccgtcccgct cgaggatccg cgtcgcctgg cggccctcca 18961 ggacgaggcc gcggaactcc tccagcaggc ccgccgcccg cagcgccggc tgtccgttgt 19021 cctcgtggat gtccagcatc ccgccctggg cacgggcgtt cggcgaggtc tccgcctcgt 19081 agacggtggc ggtgatgccg tggacatgga ggacccgggc gagcgtcagt ccgccgagtc 19141 cggcgccgat gatcgtgacg tcagtggtca tggtgattcc cttgcgtgtc gcgcggctgc 19201 cggacgggca cccggcagga tcttccgcaa ggttccggcc cggtgccgac aagccgccga 19261 catcgcaccg acagcccccg gcagatcccg acaggcgacc gacagcgcgg cccgcccccc 19321 ccattgccca tcgcccatcg ctcgccgcca tccgcccatc gcccgccgcc cgccgcgatg 19381 agttccggac gcgtcgcgag tctcccttcg tgagcgtcct gggacgccgt acggcgaacg 19441 ccgaacgccg ctgcccggca cgggacccac ccgcacgagg cagcacgccc gcccgcccgg 19501 gacggcgggc acgaggtccg acggaggaca gcatgacgac caccccgcac gatccgcacg 19561 atccggccac ctcgccgccc ggccgcccgc ccgtcgtcga cctgggcacc tggcagaccg 19621 cccgggacga gctcctggtc cgcgagaagg cccacaccca cgagggcgac gccctcgcgg 19681 cggcccggcg ccgactgccg atggtggagt tcgacgggac ggtcgaggtc gtcggacccg 19741 agggcccggt cccgttcctg gacctgttcc agggccgcga cgagctcatg gtctacaaac 19801 acatgtggta cgacgacacc ccgcaccagg ggcagtgcga gggctgcacc accacggcct 19861 ggcacctgaa ggacgccgtc tatctcaacg cccgcggcgt ctcgttcgcg atcctgacca 19921 cgggccgctg ggacgaggtg gcctcctacg tcgagttcat gggctacacc cagccctggt 19981 actcggtgcg tgaggtggcg gcgccggtcg gcggcgacat gggttacctc acctgcttcc 20041 tgcgcgacgg cgaccgcacg ttcctcacct actccacgac gggccgcggc aacgagccgg 20101 tcaacgggtc cctcgccctg ctcgaccgga cgccctacgg ccgcggcgag gcgtgggagg 20161 acaaccccga gggccggccc gaggggggca gcccgtgctg gtcctggcgc acggacgcgg 20221 acggcaacgc cacctggggc ccgaccagcc gccccgtacc gcagtggacc cgccccggcg 20281 cgacccccgt ggagaccctc ggccggcacg gcccccacca ctgacgcccc gtcggcggaa 20341 atccggttga cccggccacg ggccgacgct gcactgtggc gaggcgtcac acggtgtggt 20401 gccggtatcc gaagggcagg ctgcggcagc gatggacatc cgccccacga ccgaccagga 20461 cctcggcgtc ttcgtcgaca cgctccacgc cgcgttcggg cgcttcccgg aaaccccggc 20521 cgagggcggc ggcggagtct ggtgggccgc gctggagatg gaccgcaacc tgctcgccgt 20581 gacggcggac gggcagcccg taggcaccgc gggcgcgtac tccttcgagc tcaccctgcc 20641 cggcgcgatc cccgtaccgg cggccggggt gaccgccgtc ggcgtcctgc cctcgcaccg 20701 gcgccagggc gtgctcggcg cgatgatgcg gcatcagctc accgggctgc gggcccgagg 20761 ggagttcctc tcagtgctgc tggcctccga ggccctgata taccgcaggt tcggctacgg 20821 accggcgacc tacacccggc ggctgacggt gccgcgccac aagggggatc tcgccctccc 20881 ccgggcgcgc gccacggccg acgcaccggt ttccgggccg acgtccggcc cggcatccgg 20941 caccccatcc ggcacggcat ccggcacggc atccggcacg atcgagctgc tgcggcgtgc 21001 cgagtgcggc gagatcctgg aagaggtcta cgaccggtac cgccgcgcgc agcccggtgc 21061 gctgtcccga ccgcaccgct ggtgggccgt gcgcgccgga cagcccccga tcgccccggc 21121 ggcacgctac gtcgccgtcc accggaacgc cgacggcgtc ccggacgggt acgcctgcta 21181 ttccctcggc gagcgcgaca ccctgaccgt cgacgagacc atcgccgtcg acgacgccgt 21241 cttcacggcc ctggcccggt tcgtgctcgg acacgacctg gtcggtgagg tcgtgttccg 21301 gcacttcccg cccgagcacc cgctgcgctg gcagttcgcg gacttccggg ccggtcaggt 21361 gagcgacgac accgactggc tctgggtccg gctgctggac gtcccgcgcg cgctgaccgc 21421 ccgcggctgg ttcacggacg gcgagctggt cctcgacgtc gacgacccgt tcctcgggga 21481 gcgcggccgc tacctgctga ccgtccggga cggcaaggcc ggctgcgtcc cgacggaccg 21541 ggagcccgac ctctcgctgg acgtgagcga cctgggctcg gtctacctcg gcggcaccgc 21601 cccgagcacg ctggtccgtg ccgggcacat ccgggcccac cgcccgggcg ccgccgtcct 21661 ggccgacgcc ctcttccgcg ccgagcgtcc cccgcactgt ctgcactggt tctgaccgcg 21721 ccgcaccggt tccgcgtgtg cgcgaccgac gtcctgggtg cgcgaccgac gtcttagatg 21781 aaagttgcac cacttttgaa cgcagtgccg cccacgcgtc gtagtgaggg gtacccggcg 21841 cgtcacgcgc gaggcgctcc agaggcgata ggtcgatcgt gccgaagaac tcacccgcgg 21901 ctgagggacg aagaaagccc ttcacccgca actggcccgt ggccagacgg cttcgggccg 21961 tgctgctgat ccccgtgctc gtcgccctcg tactcggtgg cgtacgggtg aaacgctccg 22021 tcgacacctg gcaggacgcg gacgacgcgg tgcgcgtggc ggaattgatc caagcggcga 22081 acaaatacgc gagcgacgcg atcaacgagc gcgatctgtc ggtcatcccc ctgctgacgg 22141 gcgcgaggac ctccgacacc gtcgtacagg cccggaagat caccgacgcg gacgcgcggg 22201 tgttcgacgc ggcggtcggc cggatgccga agaccgccgg cctcgtccgg cgcgtccagc 22261 tggtccgcgc cggtgaggca caactcaccg ccgtacgggc caacgcgttc acctcccgga 22321 tgtccggagt gcggaccgag gagagctacc acaccgtcca gcaccccttg atggagatct 22381 cgaacgaact gggcttcggc agcagcagcc aggcgagcat cggccggacg ctctacgccg 22441 tgtccctgac ccaggccgcc gagtccctga tccgatccat cgggacccat ctgctggtgg 22501 aggaccgcga ccggctggcc cccggcgaac tcgcctccca gctcgcctcg ttccgctcgt 22561 acgcctacct cgaacaggtc gggctccagg agtacgtggg cgccggcacc accgaggacg 22621 tgacgaggct ccagcaggcg ctcgccgccg ccgaggagcg gggcagacag cagaccgccg 22681 ccgcggccgc acaggccgcg gcggcggggc ggacgttcgt cgccccgccc ggcatcgacg 22741 tgatgatcgc cgagatcgcc gacgggaagc cggccgggga gctggccgcg cggggcatca 22801 cacccgagtc gttcttcgcc gcgtccacgc tgggcttcga cgcctaccgg ggcatccagg 22861 tgaacctcac cgacgccgcg ctcacgagcg cccacgccat cgccgacgac gcgcgccggg 22921 acgcggtcgt caacgcggcg ctcgtgctcg cctcgctgct cgtggccttt ctgctggctt 22981 cctgggtggc ccgcacgatg agcaccggaa tgcgccggct cagcgcctcc gcgatcgaga 23041 tcgccggtcg acggctgccc gctctcgtcg accagatgtc ccggcccgac tccggcgagg 23101 tggacacccg ggtcgtcccg atcccgatcc acaccaccga cgagatcggc gaggtggccc 23161 gcgccttcga cctcgtccat cgcgaggccg tccggctcgc cgccgaacag gccctgctgc 23221 ggggcaacat caacgcgatc ttcaccaacc tctcgcaccg gggccagtcc ctgatcgaac 23281 gtcagctcgc cctcatcacc agcctggagg acaacgagac cgacccggag cagctggaga 23341 acctcttccg gctcgaccat ctcgccaccc gggtccgccg caacggcgag aacctcctgg 23401 tgctcggcgg cgaacgcccc gccgagcagt gggaccggcc gctaccgctg gtcgacgtcg 23461 tccgcgcggc ctgctcggag gtggagcagt acgagcgcat ccggctctcc gggctgccgg 23521 aggcccagat cgacggccgg accgtgcccg acctcgtgca tctgctcgcc gaactgctgg 23581 agaacgcaac ggtgttctcc tccccgcact cggaggtgcg ggtgaccgcc gtgcggctcc 23641 ccgacggcag gatcacggtc gagatccacg acgagggcat cgggctggcg gcggacgact 23701 tcgcggtgat caaccgcaag ctggccgacc cgccgaccgt cgacgtcggc atctcccagc 23761 acatggggct gttcgtggtc ggcaggctcg ccgaacggca cggcatcctg gtccggttgc 23821 ggccctccgg cgagaagtcc ggcacgacgt ccctcgtgat gctgcccgcc acggtcaccc 23881 ggcccctgcc gggcaccctg cccgactccg acaccctggc gctggccctg ctcaagaacg 23941 tgcagcggcc cgagtacgcg ggtgccacgg tctctgccgg cggccaggac tccggtgacg 24001 ccttcacgga ctacgagtcg tggcaggacg aaccgcccgg gagacggccc gccgacgccc 24061 cgtccgccgc cgaaccatcg gccgccgggc cgtccgccgc cgaaccatcg gtcacggggc 24121 cgtcggtcgc cgagccggcg atgacatccc gcgcccgtcc acggcggctc tcccgccgcg 24181 ccccccgaaa cggccgccgc ccgcgcaccg gctgacagcc gcctccggac ccgcacccgg 24241 cggcgacggt cggccgagcg acggtcggtc ccgcgggccg gtgtccgagg gcccgtcgag 24301 gcgtccgtcg ggggccagtt gccggagtcg gtgcacgacg gtccgcgtcg ccgggtgatc 24361 cagcggctgc ggcgccactt catccggacc ggaccgccgg cggtccgacg cccgacgccg 24421 gacgcccgag gcccgacgcc cgacgacagt cggcggaggg cgtggccgcg cgtaagcagg 24481 gcgaccgccc ggtaccacgg ggaccaccgt gctcgggccg cgtcgcctcc ggccatcgac 24541 ggtccggatc agtcgctctc gtcgcgccgt ccagcgcgtc accggcccgc agagcggatt 24601 gtcggccaat acctcccgag gtcgccgcgg gcgcgggagg ccgcgatggg gcgctccggg 24661 ccgcgccggc ggagtccggc ggcggcgttc gcggccgtcc gcgttcggct gcgcaaccgt 24721 tgcccgggtc ctgggcgcgt ccggggccgc ggcaccggac gcggcacaca cggacctgtg 24781 ccgggtcatg agcgcgatct cccgggcgtg gcgggaggtc cgctccgcgc cgccgccgat 24841 atgcggatgt gaagcggaac ctttcgcacc gcaggagcgc cgggccggcc gcctcgtgcg 24901 ccacgtgaac acgtgcacgg gttcatgacc agtcggtgct gagccatata tccccgcatc 24961 ggacgacgat tgcgcactgt gcggcacttg tcgctgacgt ttcgtcatgg ctaggctccc 25021 gcccactttc acagttcaca cactttcggc acatggaggc cggccgccgg cgcggcctcc 25081 cgggcgtacg gggggtgggg aacgtcggca cgtcaccgat ccgccggcct cccggcccgg 25141 cgcacgagga gagacccgtc accgacgggg agccgcgccg cacgcagcgg acggacccgt 25201 cggtccctgc gcacggggcg gaccggacgg accgcccggc gccacgaaac gcccggcccg 25261 ctcggccgtc ccgggacctc aggatcctgt ggtgggtcaa cgcggccgac gggctcggca 25321 gtcaggcctc cgggctggtc ctcccgctcc tgctccttca gctcggtcac agccccggta 25381 ccgcgggatc gctggccagt gtcgccgcgc tcaccggggt cgtcctcggg ccgctcgtcg 25441 cggtaccggc ggaccgggga cggcggcgcc gcctcatgac gggttcggcg gcactcgcgg 25501 ccctggcgac gggggtactg gcgctggcct gtctgggccg gcccgcgttg tgggtcgtgg 25561 tgtcgctggc cctggcggag cggctgtgcg ccgtggccta cgaggccgcg tcacgcggcg 25621 ccctcgtccg tctggcgacc gtcgacgagc tgccccgggc ggcggccggt atgcagatgg 25681 gcgaccaggc cgcactcgtc ctcggtccgg tgctcggcgg tgctctcttc caactcgccc 25741 ggccgctgcc cttcctggcc gacgccctct cctacgcggt cgccgcgctg ggcgtccggg 25801 ccgtccgcac ccccctcgac acacccgcac cgacaacgcc gtccggctcc ggcgcccgtc 25861 ggcgagggac atggcccgag cggttcgccg ccgcgagagc cggcgtggtc acggtggccg 25921 ggtccccggt gctgcgcctc gtgctggtct ggacgtcagc ggccgggggc gcgctgacgt 25981 tgctgttcta cacggcgctg ttccggctgg gcggcgacga gcggagcacg gcggccggtg 26041 tggtcctcgc cgtgtccgga gcgaccggcc tgctgggctc gctggccgcg gcccccgccg 26101 tacggcggat cggtgcggcc cgcctgctga cggtgaccgc ctggctgctg ccgctgccgt 26161 gctgcgcgct gatgtgggtg gacggcgcgg tcggctgggg agtggcgttc gccgggctgt 26221 ccctgctggt gccgctgatc accgtggtgc tggccggcgc cgccgtcgcg tgcacaccgg 26281 tggagctcca gtcccgtacc gcgagtgtgc tcggctcggt gtccgccctg gccgcggccg 26341 gtgcgccggc gctcgccgcc gtcctggtca ccgtctggag ctcccgcacg cccgcgctgc 26401 tggtcaccgt gctgttcgcg gcactggccg ggtacacgca gctgcgggcc cccgtcgtac 26461 tgcgcgcggg tgccgcggcc gccgccggga cgggagacgg ccgtggctga cgacttcacg 26521 gtcttcctcg gcgccctgcc tcaggtgtgc ccgcgtgacg cgcggcgcat ggtgctgacg 26581 gccgacgccg acggccgttg cgaggtgttc acctgggacg cggccaccag gagcacgcgg 26641 caggtcacgg accggccccg gggaacggtg cactgcgcca tcgacgccga cgcgtacgtg 26701 tggtggttcg acgaggacgc cgagggccgg gggcactggt ggttccagcc gttcgacgga 26761 ggctgccggg tgcccggcct gcccggtgtc ccggccgcgc tgccgcgcgg tctggcggtg 26821 acggccgacg ggacggtcgc cgcggcactc gcgtcccggg acggcggcac gaggctgttc 26881 gccggacggc gcggccgggt gccgcgcgag atcctcggga tcgccgggga gggccggctg 26941 ggcggtgtca ccccggaggg cgatctggtg gctctggcca cggtgtccga cggtgacacg 27001 agcgtcgtgg tcgtcacccc ggccggccgg gtcgtcgccc ggctgcccga gacccgcggt 27061 ccggccggca ggttctggtg ccggggcttc tcgccgcggc ccggccggtc cgcactgctg 27121 ctggtgcacg agctggagga cggctaccgg ttggccacgt ggacgccgtc cggcggtctg 27181 gtcacgcact cctggtgccg tttcgacacg gagatcaccg cccgctggta ccccgacacg 27241 gacgaggtgc tggtgcgtca ggagcgccac ggacgctcgc tgctgcaccg ggtccgcctg 27301 cacgaccgaa cccgccgggt cctccccact ccggccggga gcctgctgga cgccgccccc 27361 cggccgggcg gagggctgca ctatctgtgg acggacaccg cccacccgcc cgtcccgcac 27421 gccaccgacg gggtcgccct gccgacgccc ggtccgctgc cccgcgtccc cgggcggcac 27481 accgaggtgt ggacccggac gcccgacggc ccggtccaca cgctgctcag cctgccgcgc 27541 cccgacggcg gccggcccgg cggggcggat gccgacggcg acgaggcacc gccgccggcc 27601 gtgttcctgg tgcacggcgg ccccgccgac cacgaccggg acgcctacga cgccacggtg 27661 cactcgctgg tggcctccgg ctatgccgtg gcgcgcgtca actaccgcgg gtcgaccggc 27721 tacggtccgc gctggcggcg gaccctggga ccgggtgtcg gccatccgca ggtggacgac 27781 ctggccgcgg tgcgcgccga tctcgtcggt cgcgggctgg tcgacgaccg ggcgacggcc 27841 ctgtggggag tgtcctgggg ggcctatctg gtgctgctcg ccctcggtac ccgcccgggg 27901 ctgtggcagg ccggtgtcgc ggtgaagccc gtcgccgact gggtgaccgc ccaccggctg 27961 accacccccg cgctgcgcgc cctggacgtc cgctggttcg gcggcacccc ggagcaggtg 28021 ccgcggcgct acgcccacag ctcgccgctc agcttcgcgg cgcaggtgcg ggcgccgctg 28081 ctcgtggtcg gtgccgacaa cgacgtcaag tgcccgccgg aacagatccg cagctacctc 28141 ggcgcgctga ccgcggcggg cgtggcccat gagcagatgt ggctcgacac cggccacgac 28201 ggctacgacg gcgcggctca cgtcgcggtc ctgcgccgct cactgacctt cctgcgtgcg 28261 cggctgcccg cgccggcgcc cccttcgcgt cccccggctc gcccgggagg accccggccc 28321 cgctgatcga cacagcggga ccgggtcgtg cacagcacca cccgcccgaa gaacacgcca 28381 tgaatccgag aaggaggacg actgtgcaga aggacatcat ccacaacgac ccgctggcgg 28441 gcgacgagga gaaccggaag ccgggcatcg gcatcaccat caccatcccg ttccgcaacg 28501 ccgccgagag cgacgacgag gagtgagcca cggcccggcc ggcccgctcc gacctgggcc 28561 ggccgggctc cctcccgcac tcccgcactt cccgcacttc ccgcacttcc cgcactcccg 28621 aacttcccgc actcccccgc tcttcaccgc gcctcccgca cctctcgtcc cgccggccgc 28681 ccgtgcgcaa ggagcccatc gtgcgcgttc ttctcgtcaa catgccctgg tccccgatag 28741 acctgccctc actggcgctc ggcatcctga aacgcagcgt cgacgatcac gtccaggacg 28801 ccacgtgcga ggtgctgcac gccaatctgg agttcaccga ctggatcacc gcccgctccg 28861 agttcacggc cgaggactac gagtactacg ccctctcctc ctacttcctc ggctgcggtg 28921 actgggtgtt ctcctcggcg ctctacgacg acccggcgtg gcgggacgcg cagttcgtcg 28981 atgcgatgac gtcgaagctg cgccggtccc ggatgcgcat gacccgcgaa ctgcaccgcc 29041 tcgtaccgga gttcgtcgac gaggtggccc gccgtgtcgt ggctctcgaa cccgacgtgg 29101 tcgggttcac ctccaccttc cagcagaaca ccgccgcgct ggcggcggcc cggcacatca 29161 agcggctcgc cccgcaggtc gtgaccgtga tgggcggggc caactgcgac gccgaacagg 29221 gcgcggccgt ccaccgcaac ttccccttcg tggactacgt ggtccgcggc gagggcgagg 29281 acgccttccc ccggctgctg accgcgctgc gcgacggcga cccgtccgcc gtggaggcgg 29341 tcccgggcct gtgccaccgc accccgcact ccgggcacac cgccaacccc atgccgaccg 29401 ggccgttgcc gcccagtgcg atcctgcccc ccgactacag cggctacttc gaacgtctcg 29461 ccgcgtccgt ggcacgcaac tgggtggagc cgaaactggt cgtcgagggc gcgcgcggct 29521 gctggtgggg agagaagcac cactgcacct tctgcggcct gaacggctcc ttcatggagt 29581 tccgcagcaa gagccccgac gtcttctacc aggagatcat ggacctggcg gaacgccacc 29641 gggtgctcga catgtacgtg gtcgacaaca tcctggacat gcgctacctg tcgaccgtgc 29701 tgccccgcat cgtcgacagc ggctacgacc tgcgcatgca catcgagatc aaggccaaca 29761 tgcggcgccc ccagctgcag gtgctggcgg acgccgggct catctacgtc cagccgggca 29821 tcgagagcct caacagccgc gtcctcgacc tgatggacaa gggtgtcagc ggctgccaga 29881 acgtccgcat gctgcgcgac gcggcggaga ccggactgtc ggtgtcgtgg aactacctgc 29941 acggctttcc cggagagacg gccgacgact acgaacccgt catccgccag ctccccgccc 30001 tggaacacct caacccaccg gtcgacctgt ccgcccgtat cgccatcgag cgtttcagcc 30061 cctacttcaa gcgccccgag ctgggcttca ccgggctgcg gcccgaggag cactacctgt 30121 tcacctacga cctgcccgag gcggaattgc acgacctggc ctatgtcttc caggcgcccg 30181 aacgcggtat caccgaaccg acggtcggcc tcctcaacga cggcatcgcc gcatggaaga 30241 agcaccacgc cgacgcccgc ctcacccaca ccgacctggg cgaccggatc gtgctggtca 30301 gcaggcggcc gtccttcgcc tggcggacca tgcagctcac cgatccgttc gagaccgcgg 30361 tcttccggct cctggaccag ccgcacaccg tcgtggcgct gcaccgcaag ctgacgtcgg 30421 ccgccgtcgc cgccggggac gcgccgcgca cggcgcggga ggtcgaggcc ctcctgacgg 30481 agtgggtcgc gcagggcgtg gtgttcaccg acgcgggcca gtacgtgcac ctcgcccccg 30541 ccgccgtgaa ccaggacctg ctgcgtctgg actacatgcg tcacacccac acccgcggcg 30601 aggccacggc gccggccggt gccgcgcccg agcccgagcc cgagccggcg cccgcgcccg 30661 cgcccgtccc gtcctgagcg tcggcctccg tacctccctc ccccaccgcc ccgctccacc 30721 gaaccggacg aaggaccgcc catgacagcc accgcaccgg acctcgcgat acgtgcctgg 30781 cgcgatctcg acccgcaggc ccgtcacctg ccgggcatgt cgctgggttc cctcccggtg 30841 accgcgcggg accgggaggc cgaccgcctc tgggacctgg gcgtgcgcca cgccgaactc 30901 gacgcgcccg tcgacctgtc caccgacgat cccgcggtgc atcgccggac cgtcgaccgg 30961 ctgtgtctcg tccgcgatct caccgcccgc gccgtctccg tcgactggga cctgcggctc 31021 tcgccccggg agtccgccca ccagtggaag gtgctgtccc acctccagcc gccccgcacc 31081 ctcacgggcc tcgacgacgc cgaggaggca ctgcacgcct ggcggacccg ccactacctg 31141 tgcaagctgg tctggcgtca ggggccgggc ttcgtccaga tccgggaccg ccgctggggg 31201 gacctgcgcc gtttcaccgc cgtcgaaccc cactaccggg aggcgatcgc ccttctcggt 31261 cccggcgtgc accacgccga cgtacccgcc gacgtgctgg aggagttcgc ggccgagcac 31321 ctgctcctgc gcgtcggcga gctggcctgg tggctgccct accgggtctc ccgctggctc 31381 caggaggcca tggccgtgtg agtccgcagg cccgctctcc cggagcgcgc tctcccgggc 31441 ccgcccgccc cgctccggcg gacttccgga gcggggagga cacgccgccg gatggcccat 31501 agcggccttt tcggacctca cggccataac gtacacaata tgaagaaatg ccatatcgcg 31561 tacttggcgt gcaccgcggc gctgatcggg acgggcctcg gcgccgctcc gccggtcgcc 31621 gcgcacagga tccatgtggt ccacccgggg gaatccatcc agaaggcggt ggactcggcc 31681 cgtccgggcg acaccgttct gctgacctac ggcacctatc acgagagcgt cgacgtgagc 31741 acgcccgggc tcaccctgcg cggcgtgggc cgcggcacgg tgctcgagcc ggcgacggcc 31801 gccgccaccg gcagcaccgc cccgagcacc ggatcggccg ccggatcggg cgccgtgaag 31861 ggctcgaagg gctcaaaggg aacgaagggc ccgaaggccg cgaccagttg tgccgcgagc 31921 ggcaacggca tctgtgtcgt gggcacgaag gaccacaacg tcgacgacgt caccgtcgcc 31981 tccctgacgg tgagaggctt cgccaagacc ggcgtctacg ccaccgaggc cgacgggctg 32041 accgtgcggc acgtcaccgc cgagaagaac ggcgtatggg gcatcgccac cgagcactcg 32101 gtgcacggcc tgttccgcca caacaccgcc cgcgacaacg gcgacgcggg cctcttcctc 32161 gccaacacgg tcaaggagga gctgggcgcc acggacaccg agggaaccgt ggtcgagcgc 32221 aaccggctgg agggcaaccg gatcggtgtc accgtccgcc ggctgcgcaa cctgaccctc 32281 gcgggcaacc acctcacggg caactgcgcg ggcgtgttcg tcgtcggcga cgagaacaag 32341 ccgaaggccg gcttcgtgac ggtgcgcgag aaccgcatcg tgcgcaacaa caagtcgtgc 32401 ccgaagaccg cgcggctgga cgccctccag ggctccggca tcgtcctgac cggcgccgag 32461 gacagtctgg tcacccggaa cgtgatcaag gacaacgtcg gcaagtcccc gctgtccggc 32521 ggcatcgtcc tgttcaagag cttcgtgggc acgaccagcg accggaaccg gatcagcgac 32581 aacctgctgc ggggcaactc cccggacctc gtcaacacgg acaccggcaa gggcaacacc 32641 ttcgaaggca actcctgccg ttcgtcgaag cccgccggtc tgtgctgaag cccgtgaccc 32701 ccacgaactc caagaagaaa ggcggcacat gacgaccact cagtctgccc ctccgccgtc 32761 gatgcggctg cgggaactcg cgttcggggc ggcctgtgcc gccgccgtgc gcgcggccgc 32821 gcggctgggc gtcgccgacg ccctcggcga cagccccatg gccgtggagg acctcgcggc 32881 cgcggtcaag accgaacccc gcccgctgcg acggctgctg cgggccctgt cctgctacgg 32941 cgtcttcgcc gaggggccgg acggcacctt cgcgcacacc gacgtctccc ggctgctgcg 33001 cgaggatgac cccaacagcc tgcgcgccat cacgctgtgg tgcaccgagc cgtggacctg 33061 ggacgcctgg ccgatgctgg acgaggcggt gcgcaccggc cgcaacgtgg tggaggacct 33121 gtacggcaag gagttcttcc cctacctcaa cgaggacgcc ccggagtcgg ccgacgtctt 33181 caaccgtgcc atgacgacct ccagcgtgca gtcggcgcgg gacgtcgccg agttcctcga 33241 cctgacgggg agctcgtcgg tcgccgacat cggcggcggc caggggcacg tggtggccag 33301 cctgctggac aagtacccgt cgatgcacgg ggcgctgctc gacctccccc gggtggtgga 33361 gaacgcggtg ccgcgtctgc tcgcgggcgg cgacctcgcc ggccgcgcgc gcgtcgtgcc 33421 cggcgacgtc cgcgcgtccg ttccggtgaa ggccgacgtc tacgtcatca agaacatcct 33481 ggagtgggac gacgagagca cggcccgcgc gctgcgcaac gtccgtgagg cgggcggccc 33541 ggggacccgg gtcgtggtca tcgagaacct cgtcgacgac tcgccgtcga tgcggttcag 33601 caccgcgatg gacctgctgc tgctcctgaa cgtcggcggg gcgaagcaca ccacccagag 33661 catggtggac cggctgaccg aggcgggcct cgtcatcgac gacatcagcc cggtcaaccc 33721 ctacctgcac gcgttcgact gccacgtccc cggctgatcc gaccgcgtcc ccggatctgc 33781 ggatcccccc gtccgcccag gacgagaccc ccgcagacca ccggtcgccg ggcccgcggc 33841 gtcgcgggcc cggcgaccgg tgacggtcgg cgggggtcag ccggccggct cgcgctccca 33901 gaggtagaag cgctgcgcca tggcgtcctt cggggaacgc caggtctcgg ggtcgtacgc 33961 gctgacgtac gcggccagcc gctcgctgac gtcccggaac tcgggatgcc cggtgatctt 34021 ggcgatggcg ggtccggggt cgcgctcgga ctcgatcagg tgcatgtaga cgtcgccgaa 34081 ctggaacagg ctgcgccggt tcacaccgac gagccgcggc agctctcccc ggtcggactc 34141 ctcgaacacc ttggcgatgt cggttgcgga tcccggggcc atccgggcga cgatcagggc 34201 ttggtgcatg gcgctgtcct ccgtccggtt cagtcggtca gaccgcgggt ggcaccgcgc 34261 tcggcggcgg tcttctcgat tcggtcccgg atcaggccca gctggacctt cgagttccgg 34321 ttgatgttgt cggtcatcca ctcgtcgtcg acgggcgctt ccggcttcat cgcgaagtcc 34381 tgcgtccaca ccatccgcgt accggccggc acctcctcgt accgccagtg gatgtccatg 34441 tgggcgaagg gccccgtctc gacccggcgg gccttgacgg tgagcgtgtc gcggtccggc 34501 tcgcgttccg agacccagct ccacacggtg ccgttctcgt ccgggtgcat ggtcagccgg 34561 aacgtcgtct tgcgtccctc ccgggagagg atctcgacgg aggcgtactc gctgaacagc 34621 cgcggccagt tctccaggtc gttggtcacc tcccagacca ggtccagggg cgccgcgatg 34681 gtgatctcgt tctgggtgtg tccggtcatc tcaggctcct gtcaggaggg cgctgttgac 34741 gaggtcgagg aactgccggg gcgacttgga gcgttcggcg tcgggaggca tcggcgtgcc 34801 gtaccggttc tccagttcgc ccacgatccc cagcaggccg agcgagtcga cgcccaggct 34861 gtcgaagccg gtgtcgtcgc ggcggagtac ctccggggcg acggtgacgc cggcggactt 34921 cttcatgagt tcggccagct cttccacggt gatgcggtca gtcatgccat tcccttcctc 34981 tgctgctccg cggcgcctcg ctacgaggcg tcggtggcgc cgtgccgcag caccagcgcc 35041 gagttcgacc ccatgagccc ccggctcagg accagtgccg tgcgtacctc ggcggtacgg 35101 gcccggccgg tcacgaggtc gaggtcgtgg cagatgtcga agacgttggg ggtgggcggg 35161 atcaggccgt gctccatcgc gagcaccgcc gcggcggcgt ccatcagcgg cgccgcgcag 35221 tagccccggc cgatccccgt cttcggcgcc gtgacgggca cgcgggtgcc gtgcgccccg 35281 agggcgtcgg cgatcgccag cgcctcggcc cggtcggcct gcggtacacc gagcgcgtcg 35341 gcgaagacca cgtcgatctc ctcgggcgcg cagtcggcct cctccagtgc ctgccggact 35401 gcctgggcga gcccctcccg ggactcctcc cagcgggccg ccccggtgaa ggtcgccgcg 35461 tgcccggcca ggtaggcctg cacccgcgcg ccccgtgccc gggccgcggc ctccgcctcc 35521 accacgagca tggcgccgcc ctcggcggga acgaacccgc aggccgcgga ggtgaagggg 35581 cggtaggcgc gggtcgggtc gtcgaccgtg ctgagttcct cgtagccgag ttggcagacc 35641 accgagtagg gcgcgatcgg cgcctcggtg gccccggcca cgatcacgtc ggtgccccgg 35701 cgcaccgccc gcgccgcgtg ggcgagggcg tccaggccac cggcctcgtc ggccgcgacg 35761 accgagcagg ggcccttgaa gccgcggcgg atggagatct ggccggtgct ggcggcgtag 35821 aaccaggcga tggactggta cgggccgaca tagcgactgc ccttgcccca cagctgctgg 35881 agctcgcgct gtccgaactc gccgccgccg gaaccggccg cggtgaccac gcccacggag 35941 aagggcgcgg cgtcggtctc cggccggccg agctgggcgt cgtccagcgc gaagtcggcc 36001 gcggccatcg cgaagtgcgt gaaccggtcg gtctggacca ggaagcgttc ctcgatcgcg 36061 gccgacgggt cgaagtcgcg gacctggccc gccacccgca gcggcagatc ctcgcagccc 36121 tcgcggtcga cccgctccag gacgctgatg ccctccctgg tggacttcca gaaggtctcg 36181 gtactggctc cgttgggcgc gatcacaccg attcccgtga cggccgcgcg tggcaggggt 36241 tcgctcatcg tgtcttctcc ctcggccggt tcatgaccac cgcggactgg aagccgccga 36301 acccgctgcc caccgagagc acgctcgcga gcttgcgctc acgggccacg cgcgggacgt 36361 agtccaggtc gcactcgggg tcgggcgtct cgtagttcgc ggtcggcggt acgacctgat 36421 tggccagggc cagcacacag gcgacgagtt cgatcgctcc gatcgcgccg agggagtggc 36481 ccaccatcga cttgatggag ctcatgggcg tgtcgtaggc gtgcgtgccc aggacccgct 36541 tcaccgcggc ggtctcgtgg cggtcgttct gcttggtgcc cgagccgtgc gcgttgacgt 36601 agtcgatcgc ggtggcgtcg agccgggcgt ggtcgagggc ttcctcgatg gcccgggcca 36661 tctccaggcc gtcgctggtc aggccggtca tgtggtaggc gttgccgaac gtggcgtagc 36721 cgccgagttc gcagtagatg tgcgcgccgc gggcccgggc gtgctcgagc tcctccagga 36781 cgagtacggc gccgccctcg cccatgacga acccgtcacg gtcggcgtcg aagggacgcg 36841 aggcgtgggc cgggtcgtcg ttgttcgagg aggtggcctt gatcgcgtcg aagcacgcca 36901 tggtgatcgg cgagatcggc gagtcggagg cgccggctat gcagatgtcg gcccgcccct 36961 cctccacggt gtggaaggcg tacccgaccg cgtcgagccc ggaggtgcag cccgtggaga 37021 cggtctgcac cggaccgcgc gccccgaacc gctccgccac cgtcgaggcg agcgtgctgg 37081 gcgtgaacgc gcggtgcagg tgcggggccg cctgccggtg gtccacgtcc cagcgctgcc 37141 cgccgtggct gacggcgacg tagtcgtgct ccagccgggt ggtgccgccg accgcggtgc 37201 ccagggagac accgacccgc caggggttct cggcggcgag gtcgagaccc gcgtcgcgta 37261 ccgcttcgtc cccggcgacc agggcgaact ggatgtagcg gtcgcaccgc tctacgtccg 37321 tcgcgtccag gccgtgggcc gccgggtcga agtcgcactc ggcggcgatc cgcgaccgca 37381 gacccgccgg gtcgaagaac gtgatggccc gcgtcgccgt gcgcccgtcc gccaggaggt 37441 tccagaaggc cggtacgcct atgccgcccg gggcgacgat gcctatgccg gtgaccgcca 37501 ctcgtctcgt catgagcgca cctgacgtcg cgcggccgac tccgccccga ccaccgcggg 37561 ctcgccctcg gtctcctccg tgtcgacgtg gccgagcggc gggctcgggg ccagcgggcc 37621 gaggtggaag accatccggg cctccacctt gccgacgttg cggaagcggt ggcgcacgtt 37681 gagggggatc aggagcccct gctcgggctg gagcgggtgc ggctcaccgt ccaggtccac 37741 ttccagctgt ccgcacacga cgtacacgaa ctcctcggag tacgggtggt agtgctcagc 37801 gatgcggtcg ccgggctgga tcagggccag gcccatgaaa ccgctggtgg cgcccaccgt 37861 ggccggagtg agcatggcgc gcaggtcgcc gcctcgccgg gtgttgggct cgacctcgct 37921 gaggtccatg attctgtgac gagaagtgat cacgacttcc tccgatggtg tggtgcaccg 37981 acgtggcagg gacggggcac cgcccctgcc acgtgatggc gaatcaggcg tcgggcgacc 38041 ggcggtcggt gacgagatcc atgcgcgcca gttcgaggaa gcgcgcgaga cggccgtcct 38101 tcgacgcgga cttgccggcg gcgtcgtcct ggagcgtcgt cagctcggcc acctgtccgg 38161 ggtcggacag accgagggcc tgtaccgggt cggcggtttc gaggccgccg cgcacgtcga 38221 tcagccgtac gacgacgtcg tcgcgctgga agatcgtgct gcgcaggacc gggctgcgcg 38281 ggtcgtccgc cgccgcttcg tcctgccggg cgagcagctc ggccagcttc atgccgcggt 38341 ccggccgggc cgggtagtac agggcgtacc gctcggcctg cgggttctgc cgctcctccg 38401 ccgtcacgtg gtggacggcc ggcagcgcgg cccgggtgaa gaagacccgt gcggactcgg 38461 ggtcgttgag gtcccggtcc tgctccagat gggggttgat ggcctcttcg acggcccgca 38521 cctcgggctg ccgggagacg tgacgcagcg cggagagcag gtcgccccgc acctcgatgg 38581 cccgcaccac ccggttgccg tgcatgaaca gcgaggtgcg gcacagccgg gtggtgtcgt 38641 cgacctgcgg ctcgggtgag gcgtagtcgg cgaggatctt ggcgacgatc tcctcgctgc 38701 ccggcttgac ggtgaaggtg agcgcgtggc ggatcacgcc gtcgccgatc ctgggcgacg 38761 tctggagccg gcgcttggcc tggtcggcgg ccaccgccgg accgccggtc tcgcggacga 38821 cgtggaagcg cagcgaccgg gtgtcgcgca cacagctgtg cagcggctcc accatcgcca 38881 cgtgctcctc gctgttgacc caggcgagga acggcggggc gctctcccac tcgctggtga 38941 tcagccactg ggaggggttc tcgatggact ggcacagctg gtcgctgacg tgcccgggga 39001 cggacgcgac ctggttgcag agctgctcgt acgcctcgag gaactgctgc tgggccccgt 39061 cgtagacgtc gaccagaagg acgacgcgga gccgggaacc gtcgaacacg gactgggaca 39121 cacgttgcga cgcctgtcgc gcccgcgaac ctgcaacacg ttcggacgtg gtggtcatcc 39181 tgcgcacatc tccttcgcgg aggggatagg tgaacgtcgg ccgcggtgat gcgacgtcag 39241 cgttcctcga tcctgtgccc gtccccgcga gcgcgcgact cggatgaact acgtgggtga 39301 ctgggcggtc ggccgtcaga cgagatgggc gaagacgacc aggttgtcgg tgtagtcctt 39361 gacccgccgg tcgtaggccc ccgcgcaggt gatgagccgc acctgcgcct cggaggtgtc 39421 gccgtacacc cgttcgctgg ggaagtcggc cttgtcgaag gtctccacgc tgtccacccg 39481 gaaggacgcc ttcacgccgt cggcccgcag gacctggaag ccgtcgccct tcaccagcgc 39541 gctgagcccg gcgaagacgg ccggggaggt cttggtgtcg acgtgcccgg cgatgatcgc 39601 ggtgcccgtc tcgccgggtg aggctccctt ggcgtgccag ccgacgaggt tgacgtcgtt 39661 cgcgggaggc ggctccagct gcccggtcgg gccgatggcg aggtcgacga agggggcgtc 39721 gaccccgatc ttcgggatga acagccgcac gggccgggag cgcggcagat gcttgcccac 39781 ggcgtccccg gtgtccgctt caccggcggc cggggccggc gcgtccggtg cgcgggcggc 39841 ggggaccgag ccggcggcgg gcggggcgtg cggtgggctg ccggcgccgg tcgccgggtc 39901 gttgccgccg ccgaacaggt tcagcgccag gaccaccgcg accgcggcgc agaccatcat 39961 cacgccggcg cgggacgttc cctcttcggt gggcgccggc tcggttccgc ggggttcggc 40021 ggggtcggag ggagaagggg aggacgaagg gggaactgcc atcggggacc acctcattcg 40081 ggcacggcag cggggcggac agggcacggg gagcgagccg ggccgccacg cgggggtacc 40141 ggtggcggcc gcggcctcgc tatcgcgtcc ggcatgggtc aggccacgct tccggccgtc 40201 ttcttgcggc gcagggcgta gaggccggcg ccggcgacgc cgaggacgcc gagtccggcc 40261 gcggtcgcgg agggggtggc gagggcgccg cctccggtgt gcacgccgcc gctgggcttg 40321 tagtgctcct tgctccagcc gccggactcc tccttgccgc cgttccagga gtccttgccg 40381 tgctcaccgc cgttgtcgtc cttgtccttg tacgtctcgg //