LOCUS       NZ_LMEQ01000031        21172 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root1310 contig_5, whole genome shotgun sequence.
ACCESSION   NZ_LMEQ01000031
VERSION     NZ_LMEQ01000031.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1310
  ORGANISM  Streptomyces sp. Root1310
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 600179)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 600179)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1310
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426425.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 02:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,470
            CDSs (total)                      :: 8,385
            Genes (coding)                    :: 8,123
            CDSs (with protein)               :: 8,123
            Genes (RNA)                       :: 85
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 262
            CDSs (without protein)            :: 262
            Pseudo Genes (ambiguous residues) :: 0 of 262
            Pseudo Genes (frameshifted)       :: 98 of 262
            Pseudo Genes (incomplete)         :: 219 of 262
            Pseudo Genes (internal stop)      :: 20 of 262
            Pseudo Genes (multiple problems)  :: 64 of 262
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 79149
            Orig. end                         :: 100321
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEQ01000031.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21172
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="melanin"
                     /product="terpene"
                     /region_number="2"
                     /rules="melC"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21172
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="neighbouring"
                     /product="melanin"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10369
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10369
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5369](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5369
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     cand_cluster    120..21172
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    120..21172
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10119:11172](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10120..11172
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     misc_feature    complement(504..519)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.46"
                     /tool="antismash"
     gene            855..1223
                     /locus_tag="ASD48_RS31040"
                     /old_locus_tag="ASD48_21455"
     CDS             855..1223
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126212.1"
                     /locus_tag="ASD48_RS31040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21455"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_057605129.1"
                     /transl_table=11
                     /translation="MSDIGQTVRPDRFSVVHRMVGDVRVIVVRGEIDHDVRDALGNALL
                     PQDGGASPSRTVVDLGGVSFMDSSGINVFVAAHQAVSGTEGWLRIAAARKPVLHVLRLV
                     GVDDLIPCHPTLDQALEP"
     gene            complement(1237..1842)
                     /locus_tag="ASD48_RS31045"
                     /old_locus_tag="ASD48_21460"
     CDS             complement(1237..1842)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523020.1"
                     /locus_tag="ASD48_RS31045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21460"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_057605130.1"
                     /transl_table=11
                     /translation="MSAVSTPSDASAAPPPPAPARRDAEATKAAILRAARYLLARQSHA
                     DITLKAVAERAGVSAPLVLKYFGNKDALFARVMSFEEDADALLDAPPGRLGPHMVRHVV
                     ASQRERGADPLLRIAFAPLHGDHGDVLRANFRTQVTDRLAARLAGPDAAIRAELAVATV
                     LGLGVMFGIARGSELRATPIEDIVERYGPTVQAHLDGP"
     gene            complement(1839..3323)
                     /locus_tag="ASD48_RS31050"
                     /old_locus_tag="ASD48_21465"
     CDS             complement(1839..3323)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126210.1"
                     /locus_tag="ASD48_RS31050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21465"
                     /product="MFS transporter"
                     /protein_id="WP_057605131.1"
                     /transl_table=11
                     /translation="MASPAPIPARTEGAAGLRARLTIPVLAYCGILMAVMQTVVVPLLP
                     DLPRLTGASPGAVSWMVTASLLSGAVLTPVLGRAGDMYGKRRVLLVSFALMAAGSVICA
                     LTSDIGVLIAARTLQGAASSVVPLSISILRDELPPERRGSAVALMSSTVGIGAALGLPA
                     AAVVVQYANWHVMFWVTAALGATGVALIRWAVPESPVREPGRFDVTGALGLAAGLISLL
                     LAVSQGGQWGWGSARVVGLFLAAAIVLGLWWWHQLRAEQPLVDLRLVSRPRVGLSHVAA
                     LLTGFAFYANSLVTAQLVQAPEASGYGLGLSIVQTGLCLLPGGITMLLFSPLSARISER
                     RGPRITLALGAAVIASGYALRIADSRDLWMIMVGATVVATGTTLAYSALPSLILRAVPP
                     GQTASANGFNVLMRTIGQATSSAAVAAVLVHHTGLVGGVPVPTLHGYLLAFGVAGAVAL
                     AACAVALTIPGDAGPEDTRRVRGRTRSVGDGALEGA"
     gene            complement(3433..4650)
                     /locus_tag="ASD48_RS31055"
                     /old_locus_tag="ASD48_21470"
     CDS             complement(3433..4650)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069189.1"
                     /locus_tag="ASD48_RS31055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21470"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_057605132.1"
                     /transl_table=11
                     /translation="MCVKVACVGGGPAGLYLSILLKRQDPSHDITVHERNPEGSTYGWG
                     VTYWQGLLDRLRVCDPESASAIEAESVRWNEGVAHVRDLATRQPGDEGHGIGRHKLLEI
                     LAARARALGVRLEYESGITAENLPDADLVVAGDGVHSVLRTHHADDFGAELTPGRNSYI
                     WLGTTKVFDSFTFAFVETEHGWIWCYGYPFSSEQSTCVIECAPETLAGLGLDRASESDG
                     LARLGKLFAHILDGRPLIGRAAADGSTQWLTFRTLTNRSWYRGNLVLLGDAAHTTHYSI
                     GAGTTLALEDAIALAEALRESTDLPAALARYERERKSALLSLQSAARYSAQWYENLTRY
                     IHLPPEQMFALLGQRHSPLLPYVPPQLYYRLDRAAGQLGALRRFKRWLGPKLARGAHAR
                     TLTSRK"
     misc_feature    4887..4902
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.2"
                     /tool="antismash"
     gene            5001..5369
                     /locus_tag="ASD48_RS31060"
                     /old_locus_tag="ASD48_21475"
     CDS             5001..5369
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126208.1"
                     /locus_tag="ASD48_RS31060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21475"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_057605133.1"
                     /sec_met_domain="melC (E-value: 1.4e-51, bitscore: 169.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELSRRRALTAAAAVTGAALVAVPAARADDHHHDAHGSPDSFDE
                     VYKGRRIQGRPTEGGGHHHGGGYGVYVDGVELHVMRNADGTWISVVSHYDPVPTPRAAA
                     RAAVDELQGARLVPFPAG"
     gene            5413..6237
                     /locus_tag="ASD48_RS31065"
                     /old_locus_tag="ASD48_21480"
     CDS             5413..6237
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126207.1"
                     /locus_tag="ASD48_RS31065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21480"
                     /product="tyrosinase family protein"
                     /protein_id="WP_057605134.1"
                     /transl_table=11
                     /translation="MTVRKNQASLTADEKRRFVAAVLQLKRSGRYDAFVTTHNGFILGD
                     TDNGERTGHRSPSFLPWHRRFLLEFERALQSVDASVALPYWDWSTDRSPRSSLWAPDFL
                     GGSGRSRDGQVMDGPFAASAGNWAVNVRVDGRTYLRRALGTGVRELPTRAEVESVLSMA
                     TYDMAPWNSGSDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYIDKL
                     WAQWQRRHPGSGYLPGGGTPNVVDLNETMKPWNDTTPADLLDHTAHYTFDTD"
     gene            6331..6783
                     /locus_tag="ASD48_RS31070"
                     /old_locus_tag="ASD48_21485"
     CDS             6331..6783
                     /NRPS_PKS="Domain: Polyketide_cyc (9-128). E-value:
                     1.4e-17. Score: 56.1. Matches aSDomain:
                     nrpspksdomains_ASD48_RS31070_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138611.1"
                     /locus_tag="ASD48_RS31070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21485"
                     /product="SRPBCC family protein"
                     /protein_id="WP_057605135.1"
                     /transl_table=11
                     /translation="MSQVEESIEVGVPVHTAYDQWTQFETFPAFMSGVDRIEQRTDTLT
                     HWVTSVNGVRREFDAEITEQIPDERVAWTTVSGEARQAGVVTFHRLDDSHTKVMLQMEF
                     QPEGVTETVGDKLGFVKRQTKGDLERFKEFIEERGLETGGWRGVVV"
     aSDomain        6358..6714
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS31070_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="1.40E-17"
                     /label="ASD48_RS31070_Polyketide_cyc.1"
                     /locus_tag="ASD48_RS31070"
                     /protein_end="128"
                     /protein_start="9"
                     /score="56.1"
                     /tool="antismash"
                     /translation="VGVPVHTAYDQWTQFETFPAFMSGVDRIEQRTDTLTHWVTSVNGV
                     RREFDAEITEQIPDERVAWTTVSGEARQAGVVTFHRLDDSHTKVMLQMEFQPEGVTETV
                     GDKLGFVKRQTKGDL"
     gene            complement(6796..7512)
                     /locus_tag="ASD48_RS31075"
                     /old_locus_tag="ASD48_21490"
     CDS             complement(6796..7512)
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433223.1"
                     /locus_tag="ASD48_RS31075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21490"
                     /product="ribonuclease H"
                     /protein_id="WP_057605136.1"
                     /transl_table=11
                     /translation="MIGHMRERVVAACDGASKGNPGPAGWAWVVADEAETPARWEAGPL
                     GRATNNIAELTALERLLASTDPTVPLEVRMDSQYAMKAVTTWLPGWKRNGWKTSAGKPV
                     ANQELVVRIDELLDGRSVDFRYVPAHQIDGDPLNDFADRAASQAAIVQQPAGSEQGSPE
                     PPASPDTPKGKSAKTGRSAGGKSPRRSGGSASRTLKAKFPGRCVCGRPYAAGEQIAKNA
                     QGWGHPECRTADTDAG"
     gene            complement(7544..8302)
                     /locus_tag="ASD48_RS31080"
                     /old_locus_tag="ASD48_21495"
     CDS             complement(7544..8302)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126204.1"
                     /locus_tag="ASD48_RS31080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21495"
                     /product="VOC family protein"
                     /protein_id="WP_242432790.1"
                     /transl_table=11
                     /translation="MFSDVEGAKTFYGEVLGWTFGDASSEYGNYTQAYANGKAVAAVVP
                     PMPGQEGPAQWCLYLASPDAAVTAGRIREHGGEVLMEPMQVGEFGTMCLGREPGGAVFG
                     VWQAGVHEGFEAPPEQPGAYCWAEVFTREPGKTDAFLPAVFPYTAKQLQDDAVDFRMFE
                     VDGDMVLGRMKMTDEFPPEVPSYINVYFTVDNCDDAVARATKLGGVLRFGPMDTPFGRF
                     AAISDPQGASFSVIDVTTTAGDMPQTVEVS"
     misc_feature    8426..8439
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.72"
                     /tool="antismash"
     gene            8661..10103
                     /locus_tag="ASD48_RS31085"
                     /old_locus_tag="ASD48_21500"
     CDS             8661..10103
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003963.1"
                     /locus_tag="ASD48_RS31085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21500"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_057605138.1"
                     /transl_table=11
                     /translation="MSTPDSATGPALDEPAPEPTTDAQLTSLSTQAARQLATTHKSEPQ
                     MQAISSRWLLRMLPWVDVKGGTYRVNRRLQLRVGRGRVQFEQNGGNDVRVIPQTLTELP
                     VLRGYSDNGTLAELSSHFQTREVRAGQVVFEAGQPVTETYLVVHGRFTRFTAGKYGEEE
                     IVGVVSGGDQLGDEALGQDDPLWLSSVRAETSGVLLALPWGVLREFVGRVPSLAAHLEA
                     YAARQQLPMNRKGEAEVPVQAGHTGEPTLSAGFVDYELSPREYELSLTQTVLKVHTRVA
                     DLYNNPMNQTEQQLRLTVEEIRERQEWEMVNNREFGLLHNIDHGQRVSTFTGPPTPDDM
                     DDLLSMRRKTKLFLAHPKAIAAFFRQCNRRGLVPGTATVEGHEIPAWRGVPIFPCNKIP
                     ISPQHTSSIIALRTGEADQGVVGLYQTGIPEEFQPGLNVRFMGIDANSIIRYLVTAYYS
                     MAVLVPDAAGVLENVQVGRTAE"
     gene            10120..11172
                     /locus_tag="ASD48_RS31090"
                     /old_locus_tag="ASD48_21505"
     CDS             10120..11172
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126202.1"
                     /locus_tag="ASD48_RS31090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21505"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_057605139.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-55, bitscore: 183.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPTSTGSALPGPPNLARSLRARRGGAVPGLRHREVEPADPEKA
                     AEIDRRLEEWARGLDLFPTAWNGDFAGFQFGRAVVLQHPRALDLERLTVAGKLLLAENI
                     VDNCYCEEDEDKGGSRSGLGGRLIIAQSALDPYHGPPDLQREWARGVQADGPLRSYHGA
                     LKDYAALATPSQTNRFVHDIARLHLGYLGEAAWGETRYVPRIWEYLVMRQFNNFRPCLS
                     IVDAVDGYELPEQLYARPEIQRVTALACNATTIVNDLYSFTKELAADPTHLNLPQVVAA
                     NDRRGLKAAYLRSVEIHNQIMDAFEEESAVLAATSPLVERYLRGLSDWVAGNHEWHATN
                     THRYHLPDYW"
     gene            11223..12101
                     /locus_tag="ASD48_RS31095"
                     /old_locus_tag="ASD48_21510"
     CDS             11223..12101
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574303.1"
                     /locus_tag="ASD48_RS31095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21510"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_057605140.1"
                     /transl_table=11
                     /translation="MTTAHDAGTKTVPVPIQSTYQNRVADYWNAEENPVNLELGRIDDL
                     YHHHYGVGEADWSVLDEPDAELRRDRVTAELHRLEHAQAELLAASLGRLTPADRVFDAG
                     CGRGGGSVTANLRYGCHADGVTISAKQAEFANEQARKRGIDDQVRYHHRNMLDTRLETG
                     AYAASWNNESTMYVELDLLFAEHARLLRRGGRYVVITGCYNDAYGQASRKVSLINAHYI
                     CDIHPRSAYFRALARNRLVPVHVEDLTEAAIPYWELRSQADHLVTGIEETFLSAYRNGS
                     FQYLLIAADRV"
     gene            12147..13079
                     /locus_tag="ASD48_RS31100"
                     /old_locus_tag="ASD48_21515"
     CDS             12147..13079
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126200.1"
                     /locus_tag="ASD48_RS31100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21515"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_057605141.1"
                     /sec_met_domain="APH (E-value: 3.8e-32, bitscore: 107.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPKMHADEVDLDAPLVGRLVAGQFPRWAGLPVRRLASSGTENA
                     MYRLGADKVVRLPRHPGAVESVAHEQRWLARLGPKLPVAAPVPLELGAPGEGFAWPWSV
                     YRWLDGANPVAGAVEKPRALAADLAAFVTALRGIGTRGGPPNPRGVPLAERDTPTRDAL
                     ARLAGRIDTTAVTALWEEALRAPEHSEPPAWAHADLMPGNVLVRDGRLTAVIDFGCVGV
                     GDPAVDLIVAWNLLPASARAVFREGVGADDAEWARGRGWALSISLIQLPYYQETNPPLA
                     KNSRHVIREILAEARTGGAPSATAPYSPS"
     gene            complement(13064..13546)
                     /locus_tag="ASD48_RS31105"
                     /old_locus_tag="ASD48_21520"
     CDS             complement(13064..13546)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033139.1"
                     /locus_tag="ASD48_RS31105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21520"
                     /product="VOC family protein"
                     /protein_id="WP_057605142.1"
                     /transl_table=11
                     /translation="MTTDGFTTCLWFDGQAEEAAHYYVSIFKNSSIGDIGRYNEAGPGP
                     AGSVLAVEFTANGQKFVGINGGPQFTFSEAISFQIHCADQAEVDHYWTRLTENGGEPGP
                     CGWLKDRYGLSWQVIPDGLIEMISDPDPEKATRTTKAMYAMGKLDIAALKKAYDGE"
     gene            13670..14872
                     /locus_tag="ASD48_RS31110"
                     /old_locus_tag="ASD48_21525"
     CDS             13670..14872
                     /NRPS_PKS="Domain: Abhydrolase_1 (100-205). E-value:
                     1.3e-10. Score: 33.2. Matches aSDomain:
                     nrpspksdomains_ASD48_RS31110_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117989.1"
                     /locus_tag="ASD48_RS31110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21525"
                     /product="epoxide hydrolase family protein"
                     /protein_id="WP_057605143.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-07, bitscore: 26.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSGADSGLRPFRLDIPQSDLDDLYDRLDRTRWPRGLPATGWSY
                     GVPTGYLRELVRYWRHEYDWRAAEALLNEWPQFTTVVDGTDVHFAHVRSPEPDATPLIL
                     THGWPGSIVEFLDVVGPLTDPAAHGGDPADAFHAVVPSVPGFGLSGPVAESGWEAGRVA
                     DAWAELMGRLGYERFGAQGGDWGSVISRELGRAHPDRLIGVHLNLLPGAQATREPTPEE
                     LRAMSPEEREHTLRSWRRWVAFAAEETGYYLQQATRPQTLAYGLTDSPVGQLAWIIEKF
                     REWTDCEELPEEAVDRDRLLTNVMLYWLTGTAGSSARIYYERQHATGRTAAPREPSTVP
                     TALALFPAEPQIPLRHKAERTENLVRWTEFDRGGHFAALEEPDLLVGDVRAFFRQLRDG
                     G"
     aSDomain        13970..14284
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS31110_Abhydrolase_1.1"
                     /evalue="1.30E-10"
                     /label="ASD48_RS31110_Abhydrolase_1.1"
                     /locus_tag="ASD48_RS31110"
                     /protein_end="205"
                     /protein_start="100"
                     /score="33.2"
                     /tool="antismash"
                     /translation="PLILTHGWPGSIVEFLDVVGPLTDPAAHGGDPADAFHAVVPSVPG
                     FGLSGPVAESGWEAGRVADAWAELMGRLGYERFGAQGGDWGSVISRELGRAHPDRLIGV
                     H"
     gene            14999..15637
                     /locus_tag="ASD48_RS31115"
                     /old_locus_tag="ASD48_21530"
     CDS             14999..15637
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662962.1"
                     /locus_tag="ASD48_RS31115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21530"
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="WP_057605144.1"
                     /transl_table=11
                     /translation="MTPRTTLAPRAGEGDTAPSRFDDQLAAQLLNQRIVLLGTQVDEVS
                     ANRVCAQLLILSAEDPRTDIALYINSPGGSVHAGLAIYDTMRLIPNDVSTLAMGFAASM
                     GQFLLSVGASGKRFALPNARVMMHQPSAGIGGTTADIEIQAENLEHTKRTIERITAEHT
                     GRSPETISRDGDRDRWFTAEEAREYGIVDRVVESLADVRPAAQKRRVGM"
     gene            15639..16241
                     /locus_tag="ASD48_RS31120"
                     /old_locus_tag="ASD48_21535"
     CDS             15639..16241
                     /GO_function="GO:0004176 - ATP-dependent peptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971863.1"
                     /locus_tag="ASD48_RS31120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21535"
                     /product="ATP-dependent Clp protease proteolytic subunit"
                     /protein_id="WP_057605145.1"
                     /transl_table=11
                     /translation="MGTYTIPNVVERTPQGERSYDVFSRLLSERIIFIGTEIDDGVANV
                     VIAQLLHLEAASPESEISIYLNSPGGSFTSLMAIYDTMTFVRAPISTLCVGQAASTAAV
                     LLAGGDPGRRLVLEHARVLLGQPASGGRQGTVSDLTLQAKEMVRIRAQVEEVLARHTRH
                     DIATLRADMDRDKVFTAQEAVTYGLADEVLSRRPVTV"
     gene            complement(16263..16694)
                     /locus_tag="ASD48_RS31125"
                     /old_locus_tag="ASD48_21540"
     CDS             complement(16263..16694)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117992.1"
                     /locus_tag="ASD48_RS31125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21540"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_057605146.1"
                     /transl_table=11
                     /translation="MSNQALNRARVIPLRPPAERPGSAATVSPAAPAPPRPAPREPLWR
                     DLVGDVLRRERQAQERTLKDVADSARISMPYLSEVERGRKEASSEVLAAAAHALGLSLG
                     DLLARAQGELIRLGSRPSTRHSARGRTVTSSYDGLCLAA"
     gene            16967..17800
                     /locus_tag="ASD48_RS31130"
                     /old_locus_tag="ASD48_21545"
     CDS             16967..17800
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117994.1"
                     /locus_tag="ASD48_RS31130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21545"
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="WP_242432808.1"
                     /transl_table=11
                     /translation="MSTAGAPLPGIEAPRSVAPRDARELSRQFFQRLAVLEEGTHEYQY
                     ARNTLIEMNMSLVRFAAGRFRGRGDDMEDIVQTGMIGLIKAIDRFEVSREVEFTSFALP
                     YIVGEIKRFFRDTTWAVHVPRRLQELRVELAKARDELSSRLDRDPTVPELATLMNLAES
                     QVVEAQIAANGYNSSSLDAALTGDGPEHGESVLADFIGVEEERLRLVEDFHSLAPLMAE
                     LSERDRQILHLRFVEEATQAEIGERLGCSQMHVSRLIKRIIARLRHGMLDELDHA"
     gene            complement(17835..18287)
                     /locus_tag="ASD48_RS31135"
                     /old_locus_tag="ASD48_21550"
     CDS             complement(17835..18287)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379801.1"
                     /locus_tag="ASD48_RS31135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21550"
                     /product="ATP-binding protein"
                     /protein_id="WP_057605147.1"
                     /transl_table=11
                     /translation="MIEYLDGAVIPTGFDVPVEPLRRAAHYTGEPGCIAEARAFAAHFV
                     DQLRTEWCATIGDRVSGEVLLVVSELITNADRHSNGPYILELEGTESSVTVCVYDSSDA
                     LPLRFPKDPERIGRHGLEIVHAVAAEVTAERVPVGKRVRAVLTFAS"
     gene            complement(18412..19683)
                     /locus_tag="ASD48_RS31140"
                     /old_locus_tag="ASD48_21555"
     CDS             complement(18412..19683)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356481.1"
                     /locus_tag="ASD48_RS31140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_21555"
                     /product="DUF6777 domain-containing protein"
                     /protein_id="WP_242432791.1"
                     /transl_table=11
                     /translation="MITTAVVAVTALAVVLALVNGGGSGSGGGASGQVGEVFMQPAGKT
                     GPEPYIKPVVDDSSFPPASVAPSGSSPPADTVSGVDGGDDGLYGGTRNVSSCDVERQIK
                     ALRADPAKNRAFASVAGVAPSGVPAHLRSLTPVQLRLDTRVTNHGYRDGAATTYQAVLQ
                     AGTAVLVDRHGVPRVRCACGNPLTPPLAQRAGFKRTGDPWPAYSPATTVVVKPSVTVID
                     VFVLYDPRHEHHWFARRPGDKPHQDRPTRPPARLTPSITVSTPSPPTGDGPRTSPPCVS
                     PPADRPPGCPLPPSSSGSATAPPSSEPPSSEPPSKEPPSKEAPSSPSSSSESRRLAPPS
                     SESPSSEPPSSESRSGQHLVPDSPGSGSRSSSPSEPTSEPESSSSASRLPPTGGSTSQS
                     PPTSAVSSGVSSAAPGAPAGSTAV"
ORIGIN
        1 tcccggccgt ctgccgggac gcggcagggc gatgtccgca cccggggcac ggcggggtgg
       61 tgaggcgggg aggtctcgtc ttcgggacgg ccgcgggagt cgcccgcggt cacgtgcggc
      121 tgcccgcgga acacatggaa cgtagagggg ccctggcgcc gtaccgcgcc agggcccgga
      181 ggaactgcca caccatccgc cggccctgct accgtgccgg ccttctgctc ccgcatgccc
      241 gaccgggacg cggtcgggtg tgccgggatc gcggttgcgc gaccggagac cacctcgctg
      301 ccgatgccgc ggatccgggc tcgtgatctc cgcccggctg atcctgatgg cgttcggctc
      361 ctccgtcctc ccgtcggcga tcgactgacc gcacagtgca actgccgtac tgcgcaaggc
      421 ggttcgggtc ggccggaccc tgcgttctgc ctgatctacg agagaaacca taaccacgcc
      481 atcgaccaat gtctactctc gccgaggtag attttcatgc tccggatcgt gaggtatggt
      541 ctccggcgac agagtggggg cagcacagga gagcgccctc gggagaacga ggaaagctga
      601 gggccgatgg agaccggttg gcgcacacgt gacgcggacg ccggtgcctt gtcgaaccag
      661 agccggcccc gagggaccac gcctgccggg gccttggcgc ccgcggcgtc ctcggccgga
      721 cggcgggaag aggcggcggg gccgacggca tcctgttcgg cccggccgcc cgggtgtccg
      781 cggtccgaac ggtggagcgg gatcatccac gcgcaccccg cccccgggcg ggcccgagac
      841 cggtcgggca tacggtgagc gacatcgggc agacggtccg gccggaccgg ttctccgtcg
      901 tacaccgcat ggtcggcgac gtgcgcgtga tcgtcgtgcg gggcgagatc gaccacgacg
      961 tcagagacgc cctcggcaac gccctgctcc cacaggacgg tggggcgtcg ccgtcacgga
     1021 ccgtggtgga tctcggcggc gtgagcttca tggactccag cggcatcaac gtcttcgtcg
     1081 ccgcacacca ggccgtcagc ggcaccgagg gctggctgcg tatcgccgcc gcgcggaaac
     1141 ccgtgctgca cgtactgcga ctggtcggcg tcgacgacct catcccctgc catcccaccc
     1201 tcgatcaggc cctcgaaccc tgacgccccg ctgcggtcag ggaccgtcca gatgggcctg
     1261 caccgtcggc ccgtaccgct cgacgatgtc ctcgatcggc gtcgccctga gctcgctccc
     1321 gcgggcgatg ccgaacatca cgcccaggcc gagcacggtg gcgacggcga gttcggcgcg
     1381 gatcgccgcg tcgggtccgg cgaggcgggc ggccaggcga tcggtcacct gggtgcggaa
     1441 gttggcgcgc aggacgtcgc cgtggtcgcc gtgcaggggc gcgaacgcga tgcgcagcaa
     1501 ggggtcggcg ccgcgctcgc gctggctcgc caccacatgc cggaccatgt gcgggcccag
     1561 ccgccccggc ggggcgtcga gcagggcgtc ggcgtcctcc tcgaaggaca tcacccgggc
     1621 gaacagggcg tccttgttgc cgaagtactt caggaccagc ggcgcgctca ccccggcgcg
     1681 ttccgcgacg gccttgaggg tgatgtcggc gtgcgactgg cgggcgagga ggtaccgggc
     1741 ggcgcgcagg atcgcggcct tggtcgcctc ggcatcgcgc cgggcggggg ccggcggcgg
     1801 gggcgcggcg gaggcgtcgg atggagtgct cacggcactc atgctccctc cagcgccccg
     1861 tcgccgacgg agcgggtacg gccacggacc cgccgggtgt cctccggtcc ggcgtcgccg
     1921 gggatggtga gcgccaccgc gcacgcggcc agggccaccg cgcccgcgac accgaacgcc
     1981 agcagatagc cgtgcagggt cggcaccggt actccgccga cgagaccggt gtggtgcacg
     2041 aggacggcgg cgacggcggc gctggaggtg gcctggccga tggtgcgcat cagcacgttg
     2101 aagccgttcg ccgaggcggt ctgtccgggc gggacggccc gcaggatcag tgacggcagc
     2161 gccgagtacg cgagggtggt gccggtcgcc acgaccgtcg cccccaccat gatcatccac
     2221 aggtcgcggc tgtcggcgat gcgcagggcg tacccggagg cgatgacggc ggcaccgagg
     2281 gcgagcgtga tccgcggccc gcgcctttcg gagatacggg cggagagcgg cgagaacagc
     2341 agcatggtga tgccaccggg cagcaggcac aggcccgtct ggacgatgga cagcccgagc
     2401 ccgtacccgc tggcctcggg cgcctgcacc aactgggcgg tcaccaggga gttggcatag
     2461 aaggcgaagc cggtcaggag cgccgccaca tgggacaggc ccaccctcgg ccgggacacc
     2521 aaccgcaggt ccaccaaagg ctgttcggca cgcagctggt gccaccacca caggccgagg
     2581 acgatcgccg cggccaggaa cagacccacg acccgggcgc tcccccagcc ccactggccg
     2641 ccctgggaca cggcgagcag caggctgatc agcccggcgg ccagcccgag cgcccccgtc
     2701 acgtcgaacc ggccgggctc gcgcacgggc gactccggca ccgcccaccg gatcagcgcg
     2761 acaccggtcg cgcccagggc ggcggtcacc cagaacatca cgtgccagtt ggcgtactgc
     2821 acgaccacgg ccgccgccgg cagcccgagc gcggcaccga tacccacggt ggagctcatc
     2881 agcgccacgg cggatccccg gcgttccggc ggcagttcgt cgcgcaggat gctgatggac
     2941 agcgggacga cggaggacgc ggcaccctgc agggtccggg ccgcgatcag caccccgatg
     3001 tcggaggtca gggcgcagat caccgagccg gcggccatca gggcgaacga gacgagcagc
     3061 acccgccgct tgccgtacat gtccccggcg cggccgagga cgggggtgag gaccgcgccg
     3121 gacagcagcg aggcggtcac catccaggag accgcgcccg gcgaggcgcc ggtcagccgg
     3181 ggcaggtcgg gcagcagcgg gacgacgacg gtctgcatga ccgccatgag gatgccgcag
     3241 tacgccagga ccgggatggt gagccgggcc cgcagaccgg ccgctccctc ggtccgggcg
     3301 ggtatcggag cgggcgacgc catggacact ccagcagcct gacggaatcg aacaagggtg
     3361 aatggcaatt caccgtatca gtgaattgcc attcaccccc ggccggtcca tgtggccgcg
     3421 accgcctcct ggctactttc gcgaggtcag cgtcctggca tgggcaccgc gcgccagctt
     3481 cggccccagc cagcgcttga accggcgcag ggcacccagc tgtccggcgg cccggtcgag
     3541 ccggtagtac agctggggcg ggacataggg cagcaggggc gagtggcgct ggccgagcag
     3601 ggcgaacatc tgctccggcg ggaggtggat gtagcgggtg aggttctcgt accactgggc
     3661 gctgtagcgg gcggcgctct gcagcgacag cagggcggac ttgcgttccc gctcgtagcg
     3721 ggcgagggcc gccggaaggt cggtgctctc ccgcagggcc tcggcgaggg cgatggcgtc
     3781 ctccagggcg agggtggtgc cggcgccgat cgagtagtgg gtggtgtggg cggcgtcgcc
     3841 gagcaggacg aggttgccgc ggtaccagct gcggttggtg agggtgcgga aggtcagcca
     3901 ctgggtgctg ccgtcggcgg cggcgcgccc gatcaggggc cggccgtcga ggatgtgcgc
     3961 gaagagcttc ccgagccggg ccagtccgtc gctctcactc gcccggtcga ggccgagtcc
     4021 ggccagggtc tcgggggcgc actcgatgac acaggtgctc tgttcggagc tgaaggggta
     4081 gccgtagcac cagatccagc cgtgctcggt ctccacgaac gcgaaggtga aggagtcgaa
     4141 caccttggtg gtgccgagcc agatgtagga gttgcgcccc ggcgtgagtt cggcgccgaa
     4201 gtcgtcggcg tggtgcgtgc gcaggacgct gtggacgccg tcgccggcca cgacgagatc
     4261 ggcgtccggc aggttctcgg cggtgatccc gctctcgtac tccagccgca cgccgagcgc
     4321 ccgggcgcgg gcggcgagga tctccagcag cttgtggcgg ccgatgccgt gcccctcgtc
     4381 gcccggctga cgggtcgcca ggtcccgtac atgggcgacg ccctcgttcc agcggacgga
     4441 ctccgcctcg atcgcgctcg ccgactcggg gtcgcagacg cggagtcggt cgaggagtcc
     4501 ctgccagtac gtgacacccc agccgtaggt cgagccctcc gggttgcgct cgtggacggt
     4561 gatgtcgtgg gacggatcct gccgcttgag caggatcgag agatacaggc cggcgggccc
     4621 gccgccgaca caggcgacct tcacgcacac tcccgggagt caccagacgt ggttgattga
     4681 cgacgcaggg tagcagggct tgatgcgggc gccgggacac cccacctgcc cgatcgcgcc
     4741 actttcccca cgtgggccac accaccaccg cggagccggc gcgcgaaaga tcaccggaac
     4801 cggtgcgttc acggaaagga attgcccctt ccgcccggcc cggtcccctg cgcgcaacaa
     4861 gatcatcttc gttcaagatt gcacgacatg taattgattg tcctgatcac agccaacccc
     4921 tctcgggcga tttctccctt tctcccccag gtcgataggc atacggggtc gtcaaccgaa
     4981 cgcatcccag gaggtcccgc atgccggaac tcagccgtcg tcgcgcactc accgcggcgg
     5041 ccgccgtcac cggtgccgcg ctggtcgccg tccccgccgc ccgggcggac gaccatcacc
     5101 acgacgcaca cggctccccc gattccttcg acgaggtcta caagggccgc cgaatacagg
     5161 gccggcccac cgaaggcggc ggccatcacc acggcggcgg ctacggcgtg tacgtcgacg
     5221 gggtcgagct gcacgtgatg cgcaacgccg acgggacctg gatcagcgtg gtcagccact
     5281 acgacccggt ccccaccccg cgggccgccg cccgcgccgc ggtcgacgag ctccagggcg
     5341 cgcgactcgt accgttcccc gccggctgac cggccgaccg ccccccttcc gcgcacactt
     5401 ggagcaccgc acatgaccgt ccgcaagaac caggcgtccc tgaccgccga cgagaagcgg
     5461 cgcttcgtcg ccgccgtcct ccagctcaag cgcagcggcc gctacgacgc cttcgtcacc
     5521 acccacaacg ggttcatcct cggtgacacc gacaacggcg agcgcaccgg ccaccgttcc
     5581 ccctccttcc tgccgtggca ccgcagattc ctgctggagt tcgagcgggc gctccagtcg
     5641 gtggacgcct cggtggcgct gccgtactgg gactggtcca ccgaccgttc gccgcgttcc
     5701 tcgctgtggg caccggactt cctcggcggc agcgggcgca gccgcgacgg ccaggtgatg
     5761 gacggtccgt tcgccgcctc ggccggcaac tgggccgtca acgtccgggt ggacggccgc
     5821 acctacctcc ggcgcgcgct cggaacgggc gtacgtgagc tgccgacccg cgccgaggtc
     5881 gagtcggtgc tgtcgatggc gacgtacgac atggccccct ggaacagcgg ctccgacgga
     5941 ttccgcaacc acctggaggg ctggcgcggg gtcaatctgc acaaccgggt ccatgtctgg
     6001 gtcggcgggc agatggcgac cggcgtctcc cccaacgacc cggtgttctg gctgcaccac
     6061 gcgtacatag acaagctgtg ggcccagtgg cagcgccggc accccggctc cgggtacctt
     6121 ccgggcggcg ggacgcccaa cgtcgtcgac ctgaacgaga cgatgaagcc gtggaacgac
     6181 accaccccgg cggaccttct cgaccacacc gcccactaca ccttcgacac cgactgatcg
     6241 gcacccgccg gtttgcccgg cgggcctcgg gtacccgcga cggacacgca gcgacgagac
     6301 gaaccaccag gaaccaagga ggagacgatc gtgtcgcagg tcgaggaatc catcgaggtc
     6361 ggcgtgcccg tgcacacggc gtacgaccag tggacgcagt tcgagacgtt cccggcgttc
     6421 atgagcgggg tcgaccgcat cgagcagcgc acggacacgc tcacccactg ggtgaccagc
     6481 gtcaacggcg tgcgccggga gttcgacgcg gagatcaccg agcagatccc ggacgagcgg
     6541 gtcgcctgga ccacggtctc cggcgaggcc cggcaggccg gagtggtgac cttccaccgg
     6601 ctcgacgaca gtcacaccaa ggtcatgctc cagatggagt tccagccgga gggcgtcacc
     6661 gagaccgtcg gcgacaagct gggcttcgtg aagcgccaga ccaagggtga cctggagcgc
     6721 ttcaaggagt tcatcgagga gcgcggtctg gagaccggag gctggcgcgg cgtcgtggtg
     6781 tgacccgcgc gccgctcagc ccgcgtcggt gtccgccgta cggcactccg ggtgccccca
     6841 gccctgcgcg ttcttggcga tctgctcgcc ggccgcgtac gggcggccgc acacacagcg
     6901 gccggggaac ttggccttga gcgtgcggga cgccgaacca ccgctccgcc ggggggactt
     6961 gcccccggcg gagcggcccg ttttcgcgga cttgcccttc ggggtgtccg gcgaggccgg
     7021 cggttccggg gagccctgct cgctgccggc cggctgctgg acgatcgccg cctggctggc
     7081 ggcgcggtcg gcgaagtcgt tgagcgggtc gccgtcgatc tggtgggcgg gcacatagcg
     7141 gaagtcgacc gagcggccgt cgagcagttc gtcgatgcgg acgacgagct cctggttggc
     7201 caccggcttc ccggcggacg tcttccagcc gttgcgcttc cagcccggca gccaggtggt
     7261 gacggccttc atggcgtact gcgagtccat ccggacctcg agcggcaccg tcgggtcggt
     7321 cgaggccagc aggcgttcca gcgcggtgag ttcggcgatg ttgttggtcg ccctgccgag
     7381 cggtcccgcc tcccagcggg ccggggtctc cgcttcgtcc gcgacgaccc acgcccagcc
     7441 cgccggtccc ggattcccct tcgaagcccc gtcgcacgcg gccaccactc gttcacgcat
     7501 gtgcccgatc atgccacggt cgggcgggcg ccccgccggg cggctaggac acctccacgg
     7561 tctgcggcat gtcgcccgcg gtggtggtga cgtcgatcac ggagaagctc gcgccctgcg
     7621 ggtcgctgat cgccgcgaac cgtccgaacg gggtgtccat cgggccgaag cgcaggacgc
     7681 caccgagctt ggtggccctg gccacggcgt cgtcgcagtt gtcgaccgtg aagtacacgt
     7741 tgatgtacga cggcacctcg ggcgggaact cgtcggtcat cttcatgcgg ccgagaacca
     7801 tgtcgccgtc gacctcgaac atccggaagt ccaccgcgtc gtcctggagc tgcttcgccg
     7861 tgtacgggaa cacggccggg aggaaggcgt ccgtcttccc gggttcgcgg gtgaagacct
     7921 cggcccagca gtacgcgccg ggctgctcgg gcggcgcctc gaagccctcg tggacgcccg
     7981 cctgccagac gccgaacacg gcgccgccgg gctcgcggcc caggcacatc gtgccgaatt
     8041 caccgacctg catcggctcc atcagcacct cgccgccgtg ctcacggatc ctgcccgcgg
     8101 tcaccgcggc atccggggag gcgaggtaga ggcaccactg cgccgggccc tcctggccgg
     8161 gcatcggcgg gacgacggcg gcgaccgcct tgccgttcgc ataggcctgc gtgtagttgc
     8221 cgtactccga cgacgcatcg ccgaaggtcc agccgaggac ctcgccgtag aaggtcttgg
     8281 cgccctccac gtcgctgaac atcgcgtcgg cccaacaagg gattccctct ggacgtacga
     8341 ccatgaccgc agccttccgg tgagacgggt tgtccggttc ctcacgctag ccatccggcc
     8401 gtccgctcgc ctgccgaaca cacgggtaac ccaaagtgac ccctgagcgc tccggcgtgc
     8461 gggggcacac gcgggaagcc tttgcacacg cggggcgcct tccgccccat caggcaggtt
     8521 tgcaccctcc ggaccatgca accgccccct tcacgccgta cccgtccgtc actcagggtg
     8581 tttggctggt gcacgcggat cttccgaacc gggcctcccg aacgggtccg cccgtctccg
     8641 cgcaccttcc tggagggaat gtgtccacac cggacagcgc caccggtcca gccctggacg
     8701 aacccgcccc cgaacccacc accgacgcgc agctcaccag tctcagcacc caggcggccc
     8761 gccagctcgc caccacgcac aagtccgaac cgcagatgca ggccatcagc tcgcgctggc
     8821 tgctgcggat gctgccctgg gtggacgtca agggcggcac ctaccgagtc aaccggcgtc
     8881 tccagctgcg ggtcggccgg ggccgggtgc agttcgaaca gaacggcggg aacgacgtac
     8941 gggtcatccc gcagaccctc accgagctgc ccgtgctgcg cggctactcc gacaacggaa
     9001 ccctcgcgga gctctcctcc cacttccaga cgcgggaggt ccgggccggt caggtcgtct
     9061 tcgaggccgg ccagccggtc accgagacct acctcgtggt gcacggcagg ttcacccgct
     9121 tcaccgcagg caagtacggc gaggaggaga tcgtcggggt cgtctccggc ggcgaccagc
     9181 tcggcgacga ggccctcggg caggacgacc cgctgtggct gagctcggtg cgcgccgaga
     9241 cctcgggcgt gctgctggcc ctgccctggg gtgtcctgcg cgagttcgtc gggcgggtgc
     9301 cgtccctcgc cgcccatctg gaggcctacg ccgcccggca gcagctgccc atgaaccgca
     9361 agggcgaggc cgaggtgccg gtgcaggccg gccacaccgg ggagccgacg ttgtcggcgg
     9421 gcttcgtcga ctacgaactc tcgccccgcg agtacgagtt gtcgctgacc cagacggtgc
     9481 tcaaggtcca cacccgggtc gccgacctct acaacaaccc gatgaaccag accgagcagc
     9541 aactgcgcct gaccgtggag gagatccgcg agcggcagga gtgggagatg gtcaacaacc
     9601 gggagttcgg gctcctgcac aacatcgacc acggccagcg cgtcagcacg ttcaccgggc
     9661 cgccgacccc ggacgacatg gacgacctgc tgtcgatgcg gcgcaagacc aagctcttcc
     9721 tcgcccatcc caaggcgatc gcggccttct tccggcagtg caaccggcgc ggtctggtgc
     9781 ccggcacggc caccgtcgag gggcacgaga tcccggcctg gcgcggggtg ccgatcttcc
     9841 cctgcaacaa gatcccgatc agcccgcagc acaccagcag catcatcgcg ctgcgcaccg
     9901 gcgaggcgga ccagggagtc gtcggcctct accagacggg tatcccggag gagttccaac
     9961 ccggcctgaa cgtacggttc atggggatcg acgccaactc gatcatccgc tacctggtga
    10021 ccgcctacta ctcgatggcc gtcctggtgc cggacgccgc cggagtcctg gagaacgtcc
    10081 aggtcggccg gacggccgag tgacggcggg gagttcgcga tgagcacgcc cacgagcacc
    10141 gggagtgcgc tgcccggacc gccgaacctc gcccgcagcc tgcgggcccg gcgcggcggc
    10201 gccgtccccg gtctgcggca ccgggaggtg gagcccgccg acccggagaa ggccgcggag
    10261 atcgaccgca ggctggagga gtgggcccgc ggcctggacc tgttcccgac cgcctggaac
    10321 ggggacttcg cgggcttcca gttcggccgc gccgtggtgc tccagcatcc gcgcgcgctc
    10381 gacctggagc gcctgacggt ggccggcaaa ctgctgctgg ccgagaacat cgtcgacaac
    10441 tgctactgcg aggaggacga ggacaagggc ggctcgcgca gcggactggg cggccggctg
    10501 atcatcgccc agtcggcgct cgacccctac cacggcccgc ccgacctcca gcgggagtgg
    10561 gcgcgcgggg tgcaggccga cggtccgctg cgctcgtacc acggggcgct gaaggactac
    10621 gcggccctgg ccacccccag ccagacgaac cggttcgtgc acgacatcgc gcggctgcac
    10681 ctgggctacc tcggcgaggc ggcctggggc gagacgcggt acgtgccgcg gatctgggag
    10741 tacctggtga tgcggcagtt caacaacttc cggccctgtc tgtcgatcgt cgacgcggtg
    10801 gacggctacg aactgcccga gcagctctac gcccgtccgg agatccagcg ggtcaccgcg
    10861 ctggcctgca acgccaccac gatcgtcaat gacctgtact ccttcaccaa ggaactggcg
    10921 gccgacccca cccatctcaa tctgccgcag gtggtggccg ccaacgaccg gcgcgggctg
    10981 aaggccgcct atctgcggtc ggtcgagatc cacaaccaga tcatggacgc gttcgaggag
    11041 gagtcggccg tgctcgccgc cacctcgccg ctcgtcgagc gctatctccg ggggctgtcg
    11101 gactgggtgg ccggcaacca cgagtggcac gccaccaaca cccatcgcta ccacctgccc
    11161 gactactggt gaccgcagcc ttttcgaccc accgtcacgc acagcaccat gaggagccac
    11221 cgttgaccac agcccacgac gccggcacca agaccgtccc ggtgcccatc cagtccacgt
    11281 accagaaccg cgtcgcggac tactggaacg ccgaggagaa cccggtcaac ctcgaactcg
    11341 gcagaatcga cgacctctac caccaccact acggcgtcgg tgaggcggac tggtccgtgc
    11401 tcgacgaacc cgacgcggaa ctgcgccggg accgcgtcac cgccgaactg caccggctgg
    11461 agcacgccca ggccgaactg ctggccgcaa gcctcggccg gctcactccc gccgaccgcg
    11521 tcttcgacgc cggctgcggc cgcggcggcg gcagtgtcac ggccaatctg cgctacggct
    11581 gccacgcgga cggcgtcacc atctccgcca agcaggccga gttcgccaac gagcaggccc
    11641 gcaagcgggg catcgacgac caggtgcgct accaccaccg caacatgctc gacacccgtc
    11701 tggagaccgg cgcctacgcg gcctcgtgga acaacgagtc gacgatgtac gtcgagctgg
    11761 acctgctgtt cgccgagcac gcccggctgc tgcgccgcgg cggacgctat gtcgtcatca
    11821 cgggctgcta caacgacgcc tacggccagg cctcgcgcaa ggtgtcgctc atcaacgccc
    11881 actacatctg cgacatccat ccgcgctcgg cgtacttccg ggcgctggcc cgcaaccggc
    11941 tggtgccggt ccatgtggag gacctcaccg aggcggccat cccctactgg gagctgcgca
    12001 gtcaggccga ccacctggtc accggcatcg aggagacatt cctgagcgcc taccgcaacg
    12061 gcagcttcca gtacctgctg atcgcggccg accgggtctg aatatccgtt ggacagcggc
    12121 gaggccggtc ctctgcaatg ggtcgcatgc gcgcgccgaa gatgcatgcc gacgaggtcg
    12181 acctcgacgc cccgctggtg ggccggctcg tcgccggcca gttcccgcgg tgggccggac
    12241 tcccggtgcg gaggctggcc tcctccggga ccgagaacgc gatgtaccgg ctgggtgccg
    12301 acaaggtggt gcggctgccc cggcatcccg gcgccgtcga gagcgtggcg cacgaacagc
    12361 gctggctggc ccggctgggg ccgaagctgc ccgtggccgc gcccgtcccg ctggaactgg
    12421 gcgcgcccgg tgaggggttc gcctggccct ggtcggtcta ccgctggctg gacggcgcca
    12481 atccggtcgc cggcgccgtc gagaagcccc gggcgctggc ggcggacctg gcggcgttcg
    12541 tcaccgccct gcgcgggatc gggacgcggg gcgggccgcc gaacccacgg ggtgtcccgc
    12601 tcgccgaacg ggacaccccc acccgcgacg ccctcgcccg gctggcgggg cggatcgaca
    12661 ccaccgcggt caccgccctg tgggaagagg cactgagggc gcctgagcac agcgaaccgc
    12721 ccgcctgggc ccacgcagac ctgatgcccg ggaacgtgct ggtccgggac ggacggctga
    12781 cggcggtgat cgacttcggc tgcgtcgggg tgggtgaccc ggccgtggac ctgatcgtcg
    12841 cctggaatct gctccccgcc tcggcccgcg ccgtcttccg cgagggggtg ggcgcggacg
    12901 acgccgagtg ggcgcgcggc cggggctggg cactgtcgat ctcactgatc cagctgccgt
    12961 actaccagga gaccaatccg cccctggcaa agaactcccg gcatgtgatc agggagatcc
    13021 tggccgaggc ccggaccggc ggcgcaccct cggcgaccgc tccctactcg ccgtcgtagg
    13081 ccttcttcag ggcggcgatg tcgagcttgc ccatggcgta catggccttg gtggtgcggg
    13141 tggccttctc ggggtcgggg tcgctgatca tctcgatcag tccgtcgggg atgacctgcc
    13201 aggacaggcc gtacctgtcc ttgagccagc cgcacgggcc gggctcgccg ccgttctcgg
    13261 tgagcctggt ccagtagtgg tcgacctccg cctggtccgc acagtggatc tggaaggaga
    13321 tcgcctcgct gaacgtgaac tgcgggccgc cgttgatgcc gacgaacttc tgcccgttgg
    13381 ccgtgaactc cacggccagc acggaaccgg ccgggccggg acctgcctcg ttgtaccggc
    13441 cgatgtcacc gatgctggag ttcttgaaga tcgagacgta gtagtgggcg gcttcctcgg
    13501 cctggccgtc gaaccagaga cacgtggtga atccgtcggt ggtcatgagt acctcctggg
    13561 cggtggaacg cggtcatcag tgtcgactgc cgttcgcccc ggaagtcatc gctcggggcg
    13621 tggggtaatc cggatggccg gtgcggcagg cgccactaac atccggcgca tgacctcatc
    13681 cggcgccgac agcggcctgc ggccgttccg tctcgacatc ccgcagagcg acctcgacga
    13741 cctgtacgac cggctggacc ggacccgctg gccgcggggg ctgcccgcga cgggctggtc
    13801 gtacggcgtg ccgacgggct acctgcggga gctggtccgc tactggcggc acgagtacga
    13861 ctggcgcgcg gccgaggcgc tgctcaacga gtggccgcag ttcaccacgg tcgtcgacgg
    13921 gacggacgtc cacttcgcgc acgtccgctc ccccgagccg gacgccaccc cgctgatcct
    13981 cacccatggc tggccgggct cgatcgtcga gtttctggac gtggtcggcc cgttgacgga
    14041 tccggcggcc catggcgggg acccggccga cgcgttccac gccgtcgtac cgagcgtccc
    14101 cggtttcggc ctgtccgggc ccgtcgcgga gagcggctgg gaggcggggc gggtcgccga
    14161 cgcgtgggcc gagctgatgg gccggctcgg ctacgagcgg ttcggggcac agggcggcga
    14221 ctggggctcg gtcatctccc gcgagctggg ccgcgcccac cccgaccggc tgatcggcgt
    14281 ccatctcaac ctgctgccgg gcgcgcaggc cacccgcgag cccacgcccg aggagctccg
    14341 ggccatgagc cccgaggagc gggagcacac cctgcggtcg tggcgccggt gggtcgcgtt
    14401 cgcggcggag gagaccggct actacctcca gcaggccacc cgcccgcaga cgctcgcgta
    14461 cgggctcacc gactcgccgg tcggccaact cgcctggatc atcgagaagt tccgggagtg
    14521 gacggactgt gaggagctgc cggaggaagc cgtcgaccgc gaccggctcc tcacgaacgt
    14581 catgctctac tggctgaccg ggacggccgg ttcgtccgcc cggatctact acgagcgtca
    14641 gcacgccacc ggccggacgg ccgcgccccg ggaaccgtcg accgtgccga ccgcgctcgc
    14701 cctgttcccc gccgagccgc agatccccct gcggcacaag gccgaacgca ccgagaacct
    14761 ggtgcgctgg acggagttcg accggggcgg ccacttcgcg gcgctggagg agcccgacct
    14821 gctggtgggc gacgtacggg cgttcttcag gcagttgcgc gacgggggct gagtccgcga
    14881 gccgggcgag gggtgctctg cccgtggcga atctgccgcg ggcagagaaa ccgcgtaccg
    14941 gcatctcccc gggtcaacag tggagtcgac ggcagtcacg ccacgacgag gagaaccgat
    15001 gactccacgc accacgctcg ctccccgtgc cggggagggc gacaccgcac cctcccgctt
    15061 cgacgaccag ctcgccgccc aactgctcaa ccagcgcatc gtgttgctcg gcacccaggt
    15121 cgacgaggtc tccgcgaacc gggtctgcgc gcagctgctg atcctgtcgg cggaggaccc
    15181 gcgcaccgac atcgccctct acatcaacag ccccggcggg tcggtgcacg cggggctcgc
    15241 catctacgac accatgcggc tgatccccaa cgacgtctcg acgctcgcca tgggcttcgc
    15301 ggccagcatg ggccagttcc tgctcagcgt cggcgcctcc ggcaagcggt tcgcgctgcc
    15361 gaacgcgcgg gtcatgatgc accagccgtc ggccgggatc ggcgggacca cggcggacat
    15421 cgagatccag gcggagaacc tggagcacac caagcggacc atcgagcgga tcaccgccga
    15481 gcacaccggc cggtcgccgg agaccatctc gcgcgacggt gaccgcgacc gctggttcac
    15541 cgccgaggag gcccgggagt acggcatcgt ggaccgggtc gtggagtccc tcgcggacgt
    15601 ccgcccggcc gcgcagaagc gacgggtggg gatgtgacat ggggacctac acgattccga
    15661 acgtggtcga gcggaccccg cagggcgagc ggtcgtacga cgtgttcagc cgcctgctgt
    15721 ccgagcggat catcttcatc ggcaccgaga tcgacgacgg cgtcgccaac gtggtcatcg
    15781 ctcaactcct ccatctggag gcggcgtcac cggagagcga gatctcgatc tacctcaact
    15841 cccccggcgg ctcgttcacc tcgctgatgg cgatctacga cacgatgacg ttcgtccggg
    15901 caccgatctc gacgctctgc gtcgggcagg cggcgtccac cgcggccgta ctgctggcgg
    15961 gcggggatcc gggccgacgg ctcgtcctgg agcacgcgcg cgtgctgctc gggcagccgg
    16021 ccagcggcgg ccgccagggc acggtctcgg acctgacgct ccaggccaag gagatggtcc
    16081 gcatccgcgc ccaggtggag gaggtgctgg cccggcacac ccgccacgac atcgccaccc
    16141 tgcgcgcgga catggaccgc gacaaggtgt tcacggcgca ggaggcggtg acctatggac
    16201 tggccgacga ggtgctgagc cggcgtcccg tgacggtgtg agacgccggc ccgcgcggct
    16261 cgtcaggcgg ccaggcagag gccgtcgtac gacgacgtga ccgtgcggcc gcgggcggaa
    16321 tgccgggtgg agggccggct gccgagccgg atcagctcgc cctgggcccg cgccagcagg
    16381 tcgcccaggc tcaggccgag ggcgtgggcg gcggccgcga ggacctccga ggaggcttcc
    16441 ttgcggcccc gctccacctc cgagagatag ggcatggaga tacgggccga gtcggcgacg
    16501 tccttgagcg tgcgttcctg ggcctggcgc tcacggcgca ggacgtcccc gaccagatcg
    16561 cgccacaacg gctcgcgcgg ggcgggccgc ggaggcgcgg gcgcggcggg agagacggtg
    16621 gcggcgctgc ccgggcgctc ggcaggcggg cgcagcggga tcacgcgggc tcggttcaac
    16681 gcttggttgc tcacctcccc agcctaggaa agcgggccgc ctccggaagg gccgggcgtt
    16741 gcgccctcgg tggaatcgga cgaaacgccc cggcgtcgcg agagtgcgca tcccgggtgc
    16801 atgggtcgcc gcggacgggg tagtcgccac ccgagtgggt ctgcctgccg gtgcccgctc
    16861 acggaccgag tacagcagac gccgaaccgt gaccttactg ggagaggcaa gggagaccgc
    16921 cgtgatccgg tcagaggcca aggccgtcga ggacaccgcc gtagccatca gcaccgccgg
    16981 cgcgccgctc ccgggcatcg aggcaccccg cagcgtggct ccgcgggacg cgcgggagct
    17041 gtcccgtcag ttcttccagc ggctggctgt cctcgaggag gggacccacg agtaccagta
    17101 cgcgcgcaac accctcatcg agatgaacat gtccctggtg cggttcgcgg ccggccggtt
    17161 ccgcggccgc ggggacgaca tggaggacat cgtccagacc gggatgatcg gcctgatcaa
    17221 ggccatcgac cggttcgagg tctcgcgtga ggtggagttc acctcgttcg cgctgccgta
    17281 catcgtcggt gagatcaagc gcttcttccg ggacacgacg tgggcggtgc acgtgccgcg
    17341 gcggctccag gaactgcgcg tcgagctggc caaggcacgc gacgagctct ccagccgcct
    17401 ggaccgggac ccgaccgtgc cggagctggc caccctgatg aacctggcgg agagccaggt
    17461 cgtcgaggcg cagatcgcgg ccaacggcta caactcctcc tccctcgacg cggcgctcac
    17521 cggggacggc ccggagcacg gcgagtcggt cctcgctgac ttcatcggcg tggaggagga
    17581 gaggctgcgg ctcgtcgagg acttccactc gctcgccccg ctgatggccg agctcagcga
    17641 gcgcgaccgg cagatcctcc acctgcggtt cgtggaggag gccacccagg cggagatcgg
    17701 cgagcggctc ggctgctcgc agatgcatgt gtcccgcctg atcaagcgga tcatcgcgcg
    17761 cctgcgccac gggatgctgg acgagctgga ccacgcctga gagccccggc ccgcgggggc
    17821 gcgcccccgc gggcctacga cgcgaaggtc agcacggccc ggacccgctt gccgaccggc
    17881 acgcgctcgg ccgtgacctc cgccgccacc gcgtggacga tctccagacc gtgccggccg
    17941 atgcgctcgg ggtccttggg gaaccgcagg ggaagtgcgt cgctgctgtc gtagacgcag
    18001 accgtgaccg aggactccgt accctccagt tccaggatgt acgggccgtt gctgtgccgg
    18061 tcggcgttgg tgatcagttc actgaccacc agcagcacct caccgctcac ccggtcgccg
    18121 atcgtggcgc accactcggt cctgagctgg tcgacgaagt gtgcggcgaa ggctcgggcc
    18181 tcggctatgc agccgggctc accggtgtag tgcgccgccc gccgcagcgg ttccacgggt
    18241 acgtcgaaac cagtaggtat cactgccccg tccaggtact cgatcatgcg tttctctctc
    18301 gaaggccgga atggccggac gccgctgggt gtgcatctgt gctcgtaccc cgtgatgcgc
    18361 cgcgcagtcc aggtcagttt tcctcttgta cgcagcacgg tcacggatgc ctcacacggc
    18421 tgtcgagccg gccggtgcgc cgggggccgc ggagctgacg ccggaggaaa ccgccgaggt
    18481 cggaggcgac tggctcgtgc tgccgcccgt cggcggaagc cgcgaggccg aggaggagct
    18541 ttcgggctcg ctcgtgggtt cggacggtga gctcgaccgg gacccggaac ccggcgagtc
    18601 gggcaccagg tgctggccgg agcgggactc ggaggacggg ggctcggagg acggggactc
    18661 cgaggagggg ggtgcgagcc tccgcgactc ggagctcgag gacggcgagg acggcgcttc
    18721 cttcgacggc ggttccttcg acgggggttc cgaggacggc ggctccgagg acgggggcgc
    18781 cgtggccgac ccggaggagg aggggggcag cgggcagccc ggcggccggt cggcgggcgg
    18841 cgagacgcac ggcggggacg tgcgcgggcc gtcgcccgtc ggcgggctcg gcgtgctgac
    18901 cgtgatggac ggcgtgagcc tcgccggcgg ccgggtcggc cggtcctggt gcggcttgtc
    18961 gcccggccgg cgggcgaacc agtggtgttc gtgccggggg tcgtagagca cgaacacgtc
    19021 gatcacggtc acggagggct tgaccacgac ggtggtcgcc gggctgtacg cgggccacgg
    19081 gtcgccggtc cgcttgaacc ccgcccgctg ggcgagcggc ggggtcaagg ggttgccgca
    19141 ggcgcagcgc acccgcggca cgccgtgccg gtcgaccagg acggccgtac cggcctgcag
    19201 gacggcctgg taggtggtgg cggcgccgtc gcggtatccg tggttggtga cgcgggtgtc
    19261 caggcggagc tgcaccgggg tgagggagcg caggtgggcc gggaccccgg agggggcgac
    19321 gcccgccacg gaggcgaagg cccggttctt ggcgggatcc gcccggaggg ccttgatctg
    19381 ccgctccacg tcacagctgg agacgttgcg ggtgccgccg tacagtccgt cgtccccgcc
    19441 gtcgacaccg gagacggtgt ccgcgggcgg cgaggagccc gacggggcga cggaggcggg
    19501 cgggaaggaa ctgtcgtcga cgacgggctt gatgtagggc tccgggcccg tcttgccggc
    19561 gggctgcatg aagacctcgc cgacctggcc ggacgcccct ccgccggatc ccgagccccc
    19621 gccgttcacc agggcgagca ccacggccag cgccgtcacg gccaccaccg ccgtggtgat
    19681 caacgcgatc cggggcccgg acttccaccg gctccggcgc ggttccccgt cgccgtcccc
    19741 cggaaagccc gcgccggacg gccgggaggg cggtcccgag ggaggctggg agggcggacc
    19801 cgagggcggg cccgacgggg gctgggaggg cggacccgcc aacgggccgg agggcggccc
    19861 cgtgggtcgg ccggaagagg gcggttctgc gctcacgagc actccccacg tgggtttccc
    19921 gcagcgcttc gacagccgac cccgagaagg cccgggagac ccgtgagacc cgggagaccc
    19981 gacaggaatc ggcgggaccc ggcgggaccc gacggggccc gcaggggcgg actgtcggac
    20041 atgcgccgct ttcttccgca acgaaccatt gtgtgcgccg gtcgggcgcg gctcgcaagc
    20101 ggggcgcgga cggccctccc gacaggcgcg ctcccccggc gctgcttagc gtggcagggt
    20161 gagcgcgtac accccgcacg accaggcagt atcccgccac ggctgggtgc gggcgatcgt
    20221 cgtggcactg gccgggctga tcgccatggg gctggtggcg gcgctgggac tgtgggcggc
    20281 cggggccacg gatctgccac agggcgcctt tccgcgggtg gtcgcggcga ccgtcgtgac
    20341 gagcgtcggc ggcacggtcg agctctccgg gaacgccggt gggctcgccg acacccaggc
    20401 cggtctgacg gtgatcccgc tgtccgtcac cctcgtcggg gcgctcgtgg tgggcgccgg
    20461 gttcctgcgg ccgctgcggc accgggcggt ggcgggcgcc gcggaactgg ccgggtgggc
    20521 ggcccggatc gccgtgctgt ggctgctcgg cctcctcgcg ctggccctgg ccgcccggca
    20581 gaccttcgcg atccccctgg gcgacgacac gctgagcgac ctcggcgaac tgttcgacat
    20641 cagccccgag gtcggcttca cgacggacgt tcccctcacc cttgtcgtcg ggctggtgtg
    20701 gctggccggt gtgctggtgc tggcgctgct ggtgtcgccc ggcgccccgt tgccgccggg
    20761 gctgctgcgc ctgcaccggt cggtgcggcc cgccgcgtac gccatggtcc tgctgctgct
    20821 ctgctgcgtc gtcctgggcc tcgtggtcgc gctcgtcgtc gcggcgaccc gcggacacgc
    20881 ctccgagacc ttcgccgtga tcctgctcgg cctgcccaat ctggtgtggc tcgcgttcac
    20941 gatcgggctg ggcgccacct ggaacggccg ggtcgagggt ccgttcgcgc tgccgatgcc
    21001 gcgggtgctg gacgaggtgc tgcgcagccc ggacgacgcg cggctgaacc tagccaccct
    21061 cgccgagcac gacggccgcg tgtggtggct cgtcgccgtg gacgcggcct tgctgctgct
    21121 ggccgcgttc gtgatggcgg cccactcccc cgccgggacg cgtgcctggc gg
//
