LOCUS NZ_LMEQ01000030 20591 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_4, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000030 VERSION NZ_LMEQ01000030.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 787452) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 787452) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 440415 Orig. end :: 461006 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000030.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..20591 /candidate_cluster_numbers="1" /contig_edge="False" /product="linaridin" /region_number="3" /rules="(cypemycin or cypI)" /tool="antismash" cand_cluster 1..20591 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(cypemycin or cypI)" /kind="single" /product="linaridin" /protoclusters="1" /tool="antismash" protocluster 1..20591 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[10000:10591](-)" /cutoff="20000" /detection_rule="(cypemycin or cypI)" /neighbourhood="10000" /product="linaridin" /protocluster_number="1" /tool="antismash" proto_core complement(10001..10591) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(cypemycin or cypI)" /neighbourhood="10000" /product="linaridin" /protocluster_number="1" misc_feature complement(10..26) /note="TFBS match to GnfM, Regulator of nitrogen-fixation genes, confidence: weak, score: 19.48" /tool="antismash" misc_feature complement(37..51) /note="TFBS match to OsdR, Development and stress management regulator, confidence: weak, score: 24.7" /tool="antismash" misc_feature 160..174 /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: medium, score: 22.14" /tool="antismash" misc_feature complement(523..538) /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 19.66" /tool="antismash" gene complement(599..1078) /locus_tag="ASD48_RS29170" /old_locus_tag="ASD48_19575" CDS complement(599..1078) /GO_function="GO:0051920 - peroxiredoxin activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015613067.1" /locus_tag="ASD48_RS29170" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19575" /product="carboxymuconolactone decarboxylase family protein" /protein_id="WP_057604728.1" /transl_table=11 /translation="MNLDIPEGRNPIEYVWGDMVPGIGLAAANFSLSVYAHTTLGLREF EAARLRIAQINGCLFCLDWRTERDEQKVEEEFADAVAEWRTTDAFDERTRLAAEYAERY ALDHHGLDDEFWDRMTAHYSQTEIVELTMSLGSWLAFGRLNRVLGLDAMCVLPGH" gene complement(1170..2243) /locus_tag="ASD48_RS29175" /old_locus_tag="ASD48_19580" CDS complement(1170..2243) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127349.1" /locus_tag="ASD48_RS29175" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19580" /product="dihydrodipicolinate reductase" /protein_id="WP_057604729.1" /transl_table=11 /translation="MISTVVWGTGNVGRAAIRAVEAHPALDLAAVLVHNPEKVGRDAGE LGGLGRGLGISATDDIAAVLSEGPGAVVYAASGDIRPDEALADIGAAIRAGAVVVTPAL YPLYDQRNAPPEFRDPVLAAIADGGGSLFVSGVDPGWGNDVLPLLMSGLGTVVDAVRCQ EIFDYSTYEQEESVRYLVGMGQPMDYEPLMLAPSIPTMVWGGQIRLMARALGVELDEIR ETLQRRALDATVSTRTMGEFEAGTQGAVRFEVQGFVKGEPRLVIEHITRIHPSCAPDWP SPPNGDGAHRVIIEGRPRIEVTVEATDEGENRSAGGNATAVGRLVGAIDWLVDAEPGLY DALDVPLRPAVGRLGGK" gene complement(2474..3961) /locus_tag="ASD48_RS29180" /old_locus_tag="ASD48_19585" CDS complement(2474..3961) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014044254.1" /locus_tag="ASD48_RS29180" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19585" /product="hypothetical protein" /protein_id="WP_057604730.1" /transl_table=11 /translation="MSSSPARHRGIRKALATALLAALTPAAAAVPAVAVPAVATPTSAA YAPVPPHNPYAGPDGTGTMHGDTGSSDTTPLAGPGAGTLTSTRAALASACPTVLIGYDG YPVALCTPIFGQVPTVHLLDPDDGSSLATLQLTKGSLLGGVYAYLDHQDRLVVADGSRS LLRVGHRQSASGAWQLSVDQRLSLASAIPSDDAVTGLSPDWQGRVWFATGGGVVGVADD GTGTVRSLALPAGERVANSISTAPEGTAVTTTHATYLLTADAEGTPRISWRQAYDRGQA RKPGLLSWGSGSTPTFLGPETGTDYVAIVDNADTTVHLKVYRTSTGAEICSVPVLQASG GPGSENSPVGAGNSIFVAGTYGYPYPAVPDGAGDAVPASADFAGGLTRVDIRADGTGCT QIWDNTLRSAAVPKLSTADHTLHTVLRDPVIPGSKGTSLLDTYRYAQIDAETGLVNRSR SVGTGALYDTLQMAGTVAPDGAYLQGTVTGVLRITAG" misc_feature complement(4524..4538) /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 18.0" /tool="antismash" gene 4529..4921 /locus_tag="ASD48_RS29185" /old_locus_tag="ASD48_19590" CDS 4529..4921 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020131582.1" /locus_tag="ASD48_RS29185" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19590" /product="YciI family protein" /protein_id="WP_063887515.1" /transl_table=11 /translation="MKYMIQMNVPAAQWDTIMSSYSKDDMAAMFAHMNSLNDDLMSAGE WVDGQGLGGPSLVKTVRAGSDGRPQVTDGPAQAGHILAGYWVVDVKSEDRALEIAARAS ACPGPGGKPGSDPIEVHAIPDDPTAA" misc_feature 4538..4551 /note="TFBS match to ANR, Anaerobic transcriptional regulator, confidence: weak, score: 19.41" /tool="antismash" gene <5208..>5301 /locus_tag="ASD48_RS45655" /pseudo="" CDS 5208..>5301 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012336521.1" /locus_tag="ASD48_RS45655" /note="frameshifted; incomplete; partial in the middle of a contig; missing N-terminus and C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /product="IS5/IS1182 family transposase" /pseudo="" /transl_table=11 /translation="MGCKRVRRHRYPRPAAGRTRGRDERSGPRRR" gene complement(5386..5894) /locus_tag="ASD48_RS45660" /old_locus_tag="ASD48_19595" /pseudo="" CDS complement(5386..5894) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007500605.1" /locus_tag="ASD48_RS45660" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19595" /product="diadenosine tetraphosphate hydrolase" /pseudo="" /transl_table=11 /translation="MDNDWRTDRIGSALRGENPSVLRRLNAGFAAIGDAQFLPGYSVLL VDDPKVENCRTWPGTSAWPSCPTWTNSEKQSSGHPVVWMRRSGGSIWRSSATPMGSCMR TYGPGSSGSRPTWCECRCGSIPATGGPTSSTHSVHSTTRCARRSGTNWTVWLAELTARR S" misc_feature 5983..5995 /note="TFBS match to MatP, Cell cycle regulator, confidence: weak, score: 19.5" /tool="antismash" gene complement(6046..7515) /locus_tag="ASD48_RS29195" /old_locus_tag="ASD48_19600" CDS complement(6046..7515) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1222: dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019435957.1" /locus_tag="ASD48_RS29195" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19600" /product="NAD(P)/FAD-dependent oxidoreductase" /protein_id="WP_057604731.1" /transl_table=11 /translation="MTTAAIVGTGPNGLAAAVTLARAGLDVTLFEKADTIGGGLRSMPL FDRDVTHDICSAVHPMAAASAFFRQFELPARGVRLLQPDMPYAHPLPQGAAAVAWRDID RTARHLGQDGRRWTSLMAPLADRSDEVVGLFLSPQRSLPRSLAAPLLLARRVPAHTTSR TPFTTQAARALLTGVAAHAVGKLPSLTSTAVALLLGHLAHSSGWPLPQGGSARIADAMA ADITAHGGTIHTGHPIKDLAELSAFPLVMLDVAPKVFLDMAGPRHTLPTRYRNALRSYR YGPGAAKADFLVNAPIPWSNPLVGKAGTVHLGGTRTDILRQETATAAGRRTDTPFVLVV DPAVTDPSRACGDRTPVWAYAHVPHGDTRDPVDLIRRRIEEYAPGFTDTVIASRGLSAA QYERYNPNYVGGDISAGALTLRQSLARPTPRWDPYTTPLPGVYLCSASTPPGPGVHGMC GYFAALSALRRHHALHTPPDLSPKKGEGEVN" gene complement(7512..9227) /locus_tag="ASD48_RS29200" /old_locus_tag="ASD48_19605" CDS complement(7512..9227) /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1288: ABC transporter related protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006132584.1" /locus_tag="ASD48_RS29200" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19605" /product="ABC transporter ATP-binding protein" /protein_id="WP_057604732.1" /transl_table=11 /translation="MNIRHIVRRQRLLLGLGALLGLSGTAAALTQPLLIGDLIEAVAAD KSVAPPIALIAGLFAANALLGAAHAYLIGRAGENIVLDMRRTLTRRLLHAQLRAFNRLE HGDIFTRTVSDTSLARVALSSSVAQMITAGFTSVGCIAAMAWIDWRMLLVTAVCLGITS AAGLALARAVRTAAVMNREDTGHFGSGLLRALSALTTVKASRAEQREADRLQDLADTAR TSGVRVTRLSALLVPVTNVGTQVSLAVVIAWGMARTATGALAIADLTAFIMYLFYLVSP LVMLFMAIGEFQQGRAAIDRVSALADIDQEVSGQRSVPGDDMAPAVEFDQVTFAYAENT APAVSGVSFSLPAAGVTAVVGPSGAGKTTLFQLIERFHIPDQGTIRVRGTDTAAMPLSE LRSRIALVEQDAPLMRGTVRENLTYACPDASQSEILDAVEAAHLTGVIAGLPHGLDTEL GEGGTGLSGGQRQRLAIARALLTRPDLLLLDEATAHLDSDSEAALRVAIGDIGTRCQVL AIAHRISTAVAADRILVIEDGCLRATGTHTELMEHDATYRRLASRQLTAAGAGS" gene complement(9224..9985) /locus_tag="ASD48_RS29205" /old_locus_tag="ASD48_19610" CDS complement(9224..9985) /EC_number="2.1.-.-" /GO_function="GO:0008168 - methyltransferase activity [Evidence IEA]" /GO_function="GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1248: methyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006132583.1" /locus_tag="ASD48_RS29205" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19610" /product="class I SAM-dependent methyltransferase" /protein_id="WP_057604733.1" /transl_table=11 /translation="MPSTVQDIGYGRQFAPWYDRIFPKGAEAVATAEILSGLHPDPSAG TLEFGVGTGRIAVPLSRKVGPVTGVDSSMEMLDLLASDPAGTDVIGIHGDIRNYTDSRH YGLVYAVCSTLSMLLTAEDQQAAISRAAERLAPMGRLVIETSNRPAVEALHEGRARATL FTPYPEPGTGLQTHSTLLPGSDLWQCSHIWYEADGTTRVGNELSRLTTPDEVDGYAVAA GLTLEARYSNWDLSPYSDQYPMFLATYTKTA" gene complement(10001..10591) /locus_tag="ASD48_RS29210" /old_locus_tag="ASD48_19615" CDS complement(10001..10591) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) linaridin: cypI" /gene_kind="biosynthetic" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="ASD48_RS29210" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="ASD48_19615" /product="hypothetical protein" /protein_id="WP_057604734.1" /sec_met_domain="cypI (E-value: 2.6e-30, bitscore: 101.0, seeds: 22, tool: rule-based-clusters)" /transl_table=11 /translation="MKISTRKIPRTSPETSDLVTRGIEMALAAWLVATLLSQHPNRVFD RLRPMSFIGNLIPNWRFFAPLPARHDFHVLYRTLTTSGEQSEWKAASSITPRSWSHTVW FPKRRGEKAVFDLCFNLDAARGKRVELEKTVEFALLRGCVARSIEENDPVWPQLSGFQF LIVRHSGYDTSQAPEYMFASPFIEVPAEVAQAS" gene complement(10588..11583) /locus_tag="ASD48_RS29215" /old_locus_tag="ASD48_19620" CDS complement(10588..11583) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (67-171). E-value: 4.6e-14. Score: 44.5. Matches aSDomain: nrpspksdomains_ASD48_RS29215_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF024109.4" /locus_tag="ASD48_RS29215" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19620" /product="alpha/beta hydrolase" /protein_id="WP_057604735.1" /sec_met_domain="PF00561 (E-value: 2.3e-11, bitscore: 39.3, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 6.3e-20, bitscore: 68.2, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MNSRHDTLPRAFAGLLAGVAVTGFAAQALRHRRVLRGRGDESMFE TSKGNILAYRMTEPTAPVSSETPVLVFETAMASTAEYWYWMELNLGLNYPTLVYSRAGY GRSEFHEKEPFTLRSSVLDLEELVRHACGSRPVVIVGHSLGGYLALRAAEQMRDLVRGL CLLDPSHPGELLRSSAQAKGAEHISFNLLLMPLSLRLGLGGLLEVPAWLKNFPADLQGL CLDQYRDWKLWEAAKREWNATQQEFLGYNGELPKISVPTCLVSADRTHLTDKTVRELYS ELAAGAPRSEMHVIERTAHDELLFRKEVFHLIGQFGESLEADRAEAGEAS" aSDomain complement(11071..11382) /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS29215_Abhydrolase_1.1" /evalue="4.60E-14" /label="ASD48_RS29215_Abhydrolase_1.1" /locus_tag="ASD48_RS29215" /protein_end="171" /protein_start="67" /score="44.5" /tool="antismash" /translation="PVLVFETAMASTAEYWYWMELNLGLNYPTLVYSRAGYGRSEFHEK EPFTLRSSVLDLEELVRHACGSRPVVIVGHSLGGYLALRAAEQMRDLVRGLCLLDPSHP " CDS_motif complement(11116..11184) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS29215_0001" /evalue="1.10E-06" /label="NRPS-te1" /locus_tag="ASD48_RS29215" /protein_end="156" /protein_start="133" /score="21.1" /tool="antismash" /translation="SRPVVIVGHSLGGYLALRAAEQM" gene complement(11580..12464) /locus_tag="ASD48_RS44465" CDS complement(11580..12464) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="ASD48_RS44465" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_157880721.1" /transl_table=11 /translation="MKPRINSLLGKLVSPPSIGRDRALTVMEQTSAVTHLIHSLENLAS ARDRQPGGLNHWDEVREIHAARHPLVRRAIDVLADPRSVRTIHIARVLAAASLLAPSAP RRLRAAANSMLALTSMANNLTQPYGNDGTDQLSFHVEAAAAIARTSGKPRLIDACLWYV ALQSTMSYAAAGYAKLPSDIWRSGDALPGILRTESFGEPKAYEMAQRHPTLTKLTAHSV LALECAFPVVFLAKGRPAPLMLATLGMFHLANARVMGLGRFVWAFTSTYPAVLYAAQRR PVAPAALASGRSS" gene complement(12582..12749) /locus_tag="ASD48_RS44470" CDS complement(12582..12749) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="ASD48_RS44470" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_157880722.1" /transl_table=11 /translation="MDSLTSIVNHDERLDALHIASTQTEILSETTVPVLGTPAALAASV AVATAIHSIW" gene complement(12843..13040) /locus_tag="ASD48_RS29225" /old_locus_tag="ASD48_19630" CDS complement(12843..13040) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="ASD48_RS29225" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="ASD48_19630" /product="hypothetical protein" /protein_id="WP_157880723.1" /transl_table=11 /translation="MSPVLEMVNASEEIGSLPMDITESIHGDLDPGMFISLSDAVNTAL AVCGLPAHAAVHCAVAALTH" misc_feature complement(13227..13242) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: weak, score: 16.03" /tool="antismash" misc_feature complement(13308..13324) /note="TFBS match to NuR, Nickel-responsive regulator, confidence: weak, score: 20.82" /tool="antismash" gene complement(13628..14767) /locus_tag="ASD48_RS29230" /old_locus_tag="ASD48_19635" CDS complement(13628..14767) /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Acyl-CoA_dh_N" /gene_functions="biosynthetic-additional (rule-based-clusters) Acyl-CoA_dh_M" /gene_functions="biosynthetic-additional (rule-based-clusters) Acyl-CoA_dh_1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1006: acyl-CoA dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006131966.1" /locus_tag="ASD48_RS29230" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19635" /product="acyl-CoA dehydrogenase family protein" /protein_id="WP_057604738.1" /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.5e-23, bitscore: 77.9, seeds: 790, tool: rule-based-clusters)" /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.5e-24, bitscore: 80.0, seeds: 43, tool: rule-based-clusters)" /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.4e-51, bitscore: 170.1, seeds: 49, tool: rule-based-clusters)" /transl_table=11 /translation="MGSRLTPQQSDFAAAVREFAQRECGSPVQRDALTQGGREPHNPKI YAMLADLGWLGVCLPEEYGGAGGGLADACVFLEETSYGLVPAGGFVTTVITAKVYERFG TEEQRRAVLGGAARGQVLAVAMSEPGAGSDVAALRCRAERQPDGSWLVEGQKTWISNAH VAESMLLVARTGGDRHEGLTMFHVPMNTPGVEVRGIETMGGREVNDVFLTGVRLPPDAV VGEVGSGWRQLMAGLNHERLFLAANMLGLGRRAFDDAVAYIREREQFGRPVGSFQALRH RVADLATEIECARLLVREVASDCDARPDRLFPREASMAKLKATETAKRVALECMQMMGG YGYATEYGMERHLRAAVVSTVYGGTSEIQRDIIGKSYGL" misc_feature complement(14831..14847) /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 17.69" /tool="antismash" gene 14879..15505 /locus_tag="ASD48_RS29235" /old_locus_tag="ASD48_19640" CDS 14879..15505 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1057: TetR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004979007.1" /locus_tag="ASD48_RS29235" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19640" /product="TetR/AcrR family transcriptional regulator" /protein_id="WP_057604739.1" /transl_table=11 /translation="MKTSANDSLLARAIARPETEEKLARQILDAALEQFTTFGLRRSSV EDVAKRAGVSRVTVYRRFQSKDGLVEACLLREGSRFFQELDSAVASLPTMEDRVVEGFV VALRHTRAHPLFGGLLKLEPEVVLPYFTVQGGASLAATTDYLTAHLRRAQHTEGRPETD PRPVAELMVRVAVSFLLNPAGCIELGDEEQARAFARRYLAPLLDA" gene complement(15520..17268) /locus_tag="ASD48_RS29240" /old_locus_tag="ASD48_19645" CDS complement(15520..17268) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aldedh" /gene_functions="biosynthetic-additional (smcogs) SMCOG1017: aldehyde dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127354.1" /locus_tag="ASD48_RS29240" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19645" /product="aldehyde dehydrogenase family protein" /protein_id="WP_057604740.1" /sec_met_domain="Aldedh (E-value: 3.5e-122, bitscore: 403.6, seeds: 89, tool: rule-based-clusters)" /transl_table=11 /translation="MTHTTENADRPGGATGPGSTDTAGQPDPATTGPAGHTEPAAADTS GLTEPAPTDTSGPTAPGSTDTAAPTEPGSTADGTRADSVERRTSPPGSFTSRSPVTGEA LAAYPVHGPLDVDRAVRRARAAGTRWAALSAGKRRGHLLRWKRELASSLDTVAGIVAAE TGKPRQDAELELLLTLEHLSWAARNAGRVLRRRRVRSGAVAMHQAATVVRRPLGVVGVI GPWNYPVYTPMGSIGYALAAGNAVVFKPSEYTPGTGVLLAELFDAAVPGYAGLFTVVTG AAATGGALARSGVDKVAFTGSPGTARKVMAVCAESLTPFLAECGGKDAVIVTAGADLDA AADAIVWGAMGNAGQTCAGVERVYAVRQVHAALCEKVVERARGLRPGAGPDAAYGPMTM PDQTAVVRRHVQDALAAGAGAALGGSESAPAAGAFVEPVVLVDVPEDSPAMTEETFGPT VAVNAVADEDEAVRRANASRYALGAAVFGGSRRAGAALASRLRAGAVSVDSVLGFAAVP ALPFGGSGDSGFGRIHGADGLRAFTTPQSVTVRRFAPPVDLTSFATPAATKARAVALMR WLHSRR" gene complement(17265..18158) /locus_tag="ASD48_RS29245" /old_locus_tag="ASD48_19650" CDS complement(17265..18158) /EC_number="1.-.-.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127355.1" /locus_tag="ASD48_RS29245" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19650" /product="oxygenase MpaB family protein" /protein_id="WP_057604741.1" /transl_table=11 /translation="MGRYSRLERIRRMDPRHDHEEIFRWITRYEFPWDYMQGVSVAFLR DYGVPRISQLLDRTQEFERAGQKRYDDTVLIAYEMVRHGMDSPHGRATARHLNRIHGRY RIPNEDYLYVLATTVVGPKRWIDRYGWRPLCPQEAESLALVGRRMGEMMGITDLPADYA GFEQLHDTYEKEMFAYDPANRRVAAATLRIITDWYPRPLRPLVARLALAVLDETLLTAL GFRPQPRPVRTAAHVLLRTRALLTRHLPARPGWWPSRPKPRSYPFGWTLDDLGPHWAHH RPPTPLADENPPMERR" gene complement(18210..19865) /locus_tag="ASD48_RS29250" /old_locus_tag="ASD48_19655" CDS complement(18210..19865) /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF039352.3" /locus_tag="ASD48_RS29250" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19655" /product="DUF6114 domain-containing protein" /protein_id="WP_057604742.1" /transl_table=11 /translation="MFAFVLGFLSELARETGDWIDRVLPARRVRRSLRAWRRRRPFWAA VWVIAGGIEMVAIPLAPLPLMIRVGVGAMSAAGIAVVLVAGGIFFLFKPDQRMFVSVVT AVASLTSMATTNLGGFGIGMLAGLIGSSMAFGWMPGNRHPEEGPREPQTPQGPASARPA STQPASAQPAGAAARAERTTGATAGAERTADAPAAGDGASGRPKADEGRARYRGRRAGA RGAVLFVLTTALAAAMLPGATGAAAHPGTGLFPLPWPTNGWPWEWGSGDTSSTAPSATP SESPAAEAGPSPTGSASPGATPGPSTGPSAGPNASPSAGSDSAPDSSGGDADQGGGPDD GAGTEGPADRPGAVLGPQVTLPCLTGVDTGGLPNPEPGEMPADPDDLTALRPPVVVGDQ PGRPRAAYPVNTVYPQVGADSLTAYGAIVHGATYLGTVGGGQLKVLWVHADRLVADDYT FRLETPGQVQTIDVDLDIPQVDIYVTRLSGSLTIPVIDVATPRICIGADVVPANLPIAV QLPELSVTAVEAGQVLVDAETVNFSGLSAHSHTR" gene complement(19890..20516) /locus_tag="ASD48_RS29255" /old_locus_tag="ASD48_19660" CDS complement(19890..20516) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016573298.1" /locus_tag="ASD48_RS29255" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_19660" /product="DUF6230 family protein" /protein_id="WP_242432766.1" /transl_table=11 /translation="MRDRYAHIGNADEGRTHWRRSALMFVPCTLAVGALGIALAEGAIA ASFAVSGTAFKVSASEVTAQGVSSFPSSIGGSADDARPVLLAAVKDGTVSDVCVSLKQK LPLVGEISMLVHSGADKPLAGTNLVVNADALTGGGGKVTGVQAGRDASTLTGAPGVTGP KGVFGVQADTAVAHDLRSTAYSANGGTLTLEKLEIEFSRSGKQCF" ORIGIN 1 cccgaaccgt gcccagttct cgtggaacgc ggccgcgggg acggtcggcc tcaactggca 61 gaccgcctgg aagcagccgt ccatcgacat ggccaagacg atcttcgaca agatcaacgc 121 caaggagggg acgatctacc gcaccgacct cttcggcgcc tacaagatct ggggcgacca 181 cctgacgtac caccccctcg gtggcgcggt gctcaacaag gcgacggaca actacggccg 241 cctgcacgga cacccgggcc tgtacgtcat cgacggcgcc ctcgtcccgg gcaacaccag 301 cgtcaatccg ttcgtcacca tcaccgcact cgccgaacga aacatagaag cgatcatcgc 361 cgcggatctg taggggtgac ccgagcgcgt gctgtccgga actgcacgga ccccgtcccg 421 ggagagggag gagagcggaa cgagcagaac gacaggggac tgagcaggga acgacagggg 481 actgagaacg acagagtact gagcagggaa cgaatgagca ctgagaaaga agcgtcaggg 541 gactgagcaa ggaacggacc cagggccgcc cggactcgcc ggacggcccc ggaccggctc 601 agtgccccgg cagcacacac atggcgtcga gccccagcac ccgattgagc cgcccgaacg 661 ccagccacga gccgaggctc atggtcagct ccacgatctc cgtctggctg tagtgcgcgg 721 tcatccggtc ccagaactca tcgtcgaggc cgtggtgatc cagggcgtac ctctccgcgt 781 actcggcggc caggcgggtg cgctcgtcga aggcgtcggt cgtgcgccac tcggcgaccg 841 cgtcggcgaa ctcctcctcg accttctgct cgtcccgctc ggtccgccag tcgaggcaga 901 agagacaccc gttgatctgc gcgatccgga gccgcgccgc ctcgaactcg cggagtccca 961 gggtcgtatg ggcgtagacg gacagcgaga agttcgcggc ggcgagcccg atgccgggga 1021 ccatgtcgcc ccacacgtac tcgatcgggt tcctgccttc ggggatgtcg aggttcatcc 1081 gggactcctt cgtgttcgcc cctggccccg gccggtgaca ggaggcgcgt cctcgtggtg 1141 tcgcagggac acggaaaggg gcgtcggcgt cacttcccgc cgagccttcc caccgccggc 1201 cgcagcggga cgtcgagcgc gtcgtacagt ccgggctccg cgtccacgag ccagtcgatg 1261 gcgccgacca gccggccgac cgcggtggca ttcccgcccg cggaccggtt ctcgccctcg 1321 tcggtcgcct cgacggtgac ctcgatgcga ggacggccct cgatgatcac ccggtgcgcc 1381 ccgtcgccgt tgggcggtga cggccagtcc ggggcgcagg acgggtggat ccgggtgatg 1441 tgctcgatga cgaggcgggg ttcccccttc acgaagccct gcacctcgaa ccgcaccgcg 1501 ccctgggtgc ccgcctcgaa ctcgcccatg gtccgggtgc tcaccgtcgc gtcgagcgca 1561 cggcgctgca aggtctcgcg gatctcgtcg agttcgacac cgagggccct ggccatcagc 1621 cgaatctgcc cgccccacac catggtcggg atcgacgggg cgagcatcag cggctcgtag 1681 tccatcggct ggcccattcc gaccagatac ctgaccgact cctcctgctc gtacgtggag 1741 tagtcgaaga tctcctggca gcggacggcg tcgacgacgg tgcccaggcc gctcatgagc 1801 aggggcagta cgtcattgcc ccagcccggg tcgacgccgg acacgaacaa cgaccctccg 1861 ccgtcggcta tcgcggcgag cacggggtcc cggaactcgg gtggggcgtt gcgctggtcg 1921 tagagcgggt acaacgccgg agtgacgacc acggcacccg cccggatcgc cgcgccgatg 1981 tcggccagcg cctcgtcggg ccggatgtcg cccgacgccg cgtacaccac cgccccaggg 2041 ccttcgctca gcacggcggc gatgtcgtcg gtcgccgaga tgcccaggcc ccggccgagg 2101 ccgccgagtt cccccgcgtc gcgcccgacc ttctcggggt tgtggacgag cacggccgcg 2161 agatcgagcg ccggatgcgc ctcgaccgca cggatcgccg cacggccgac gttgcctgta 2221 ccccagacca ccgtggaaat catacgcggg agcgtaatct gacgagccgt cagtttccat 2281 acccttgcac cggactcacg gcatgcccgt ggaccgtgga gtgactcgag ttcgcgcgcg 2341 accacggtgt cgggcgatgc gggcgaacga gcctcctgag ttcgtgccac gtcagcgggc 2401 cgtctgctcg gacgaaacga cgcgacgacg cccgcctccc gggggaccgc gggaggcgcg 2461 gctcaggtcc ggctcacccc gcggtgatcc gcagtacccc ggtcaccgtg ccctggaggt 2521 aggcgccgtc cggggcgacg gtgccggcca tctgcaacgt gtcgtacagc gcgccggtgc 2581 ctacgctcct ggaacggttg acgagtcccg tctcggcgtc gatctgcgcg tagcggtagg 2641 tgtccagcag gctggtgccc ttgctgccgg ggatcaccgg gtcgcgcagg accgtgtgca 2701 gggtgtggtc ggccgtggac agtttcggta cggccgccga gcgcagggtg ttgtcccaga 2761 tctgggtgca gccggtgccg tcggcccgga tgtccacccg ggtcaggccc ccggcgaagt 2821 cggcggaggc gggcacggcg tcacccgccc cgtcgggcac ggcagggtac ggatatccgt 2881 acgtgcccgc gacgaagatg ctgttcccgg caccgacggg cgagttctcg ctgccggggc 2941 cgccggacgc ctggaggacc gggaccgagc agatctccgc gccggtggag gtccggtaga 3001 ccttgaggtg gacggtggtg tcggcgttgt cgacgatcgc gacgtagtcg gtcccggtct 3061 caggtccgag gaacgtcgga gtggagccgc tgccccagct cagcaggccg ggcttgcggg 3121 cctgtccacg gtcgtacgcc tggcgccagg agatcctggg cgtgccctcg gcgtccgcgg 3181 tgagcagata ggtggcgtgg gtggtggtga cggcggtgcc ctccggcgcg gtggagatgc 3241 tgttggcgac ccgttcaccg gccggcaggg ccagggaccg aaccgtgccg gtgccgtcgt 3301 cggcgacgcc gaccacacca ccgcccgtgg cgaaccagac gcggccctgc cagtccggag 3361 acaggccggt caccgcgtcg tccgagggga tggcagacgc cagggagagt ctttggtcga 3421 ccgacaactg ccaggcaccg gaggcacttt gacggtgccc gacgcggagc agactgcgac 3481 tgccgtccgc gacgacgagc cggtcctggt ggtccaggta ggcgtagacc ccgcccagca 3541 gcgagccctt ggtcagttgg agggtggcca gggaggatcc gtcgtcgggg tcgagcaggt 3601 gcaccgtcgg gacctgcccg aaaatggggg tgcacagggc cacgggatag ccgtcgtagc 3661 cgatcagcac ggtggggcag gcggatgcga gcgctgcccg tgtcgacgtc agggtgcctg 3721 cgcccggacc ggcgagcggt gtggtgtcgg aggagccggt gtcaccgtgc atggtgcccg 3781 taccatcagg tccggcgtag ggattgtgcg gcggaaccgg ggcgtaggcg gcggaagttg 3841 gtgtcgcgac ggcgggtacc gcgactgcgg gtaccgcggc ggcggccggc gtgagagccg 3901 cgagcagggc ggtggccagc gctttgcgga tgccgcggtg gcgggcgggc gaagaggaca 3961 tggcgaggac aggatccttc cgtgcgacgg agatccgtac tgggtgtcgg ggcagtgcgc 4021 gcgagggcac gcggccggag ccggccggac ggatgcgtcg gcctgggcgg acatggctgc 4081 gtgcgaccgg ggctgctacg gggatgcggc ggaagccggc agcgtcaagg ggcggtggtg 4141 cctggaacgg cagccgtcgg ggtcagagcc cgtgctgaca gagggcgccg gaggttcgcg 4201 cgagatcgac gtggtgtcgg cgcgtgagaa cccggcacag agacttcatg tccatgatcg 4261 aagcagcttc gtacgggcat ggtcaagtgc agaccgccga tcgtcccgcc gtggcgggac 4321 agcgcgcctc ggcggcgaca gaccgttgtg gggcggccgt aggtcctcgt cgtcctccgg 4381 cctgcggagg tggcggacga ggcgggcctc gcctcgagcg gtagggggaa gccctcgtcg 4441 gagggcaccg atgagttttg cggctgccgc ccgtctacct ctctgcaagc ctcagaagcg 4501 cagcggctac ccgggaagtg tgaggaacat gaagtacatg atccagatga acgtgcctgc 4561 cgcccagtgg gacaccatca tgtcgtcgta ctccaaggac gacatggcag ccatgttcgc 4621 tcatatgaac tccctcaacg acgacctcat gtccgccggg gagtgggtgg acgggcaggg 4681 cctcggggga ccctcgctgg tcaagacggt gcgggccgga agcgacggac ggccgcaggt 4741 gaccgacggg ccggcccagg cggggcacat cctggccggg tactgggtgg tcgacgtcaa 4801 gagcgaggac cgggccctgg agattgccgc acgagcgtcg gcgtgtcctg gccctggtgg 4861 gaagcccggc agcgacccga ttgaggtgca cgcgatcccc gacgacccga cggcggcctg 4921 accgaccgtg tgtggcggcg tccgggaacg ggcgagccgg gagctgggag ccgccgccac 4981 cgagctgcag gagcacctcg ccgaaaggcg cgatgacgat gacgggaggt gcccgccgat 5041 cgagtgatcg acgggcctcc ggatcgcctc gccctggtgg cccggttgac gagcatcacc 5101 aatccgccat ccccgatccg cgcattgcgc agttccggat ccatggtgag cggggctcgg 5161 ggacgaggtc cggtcgagcg gccgcattcg gcgcaggcaa gaacgccaag ggctgtaagc 5221 gggttcgtcg tcaccgatac cctcggcctg ctgctggccg tacacgtggt cgcgacgagc 5281 gttcaggacc gcgacggcgc ccgccgaccg cttctgtgga gccgcctcga ccactcgggt 5341 gtatggaaga tctgggccga tcggggcttc gccgatcgcc aggactcaag acgaccgctt 5401 cacgatctgc gtgctgtcag ctcggcgagc cagacggtcc agttcgtccc cgatcgcctt 5461 gcgcagcggg ttgtgctgtg gaccgagtga gtgctgcttg tcggtccacc tgtcgcgggg 5521 atagagccac accggcattc gcaccaagta ggccggctcc cactcgaacc ggggccatac 5581 gtgcgcatgc aggaacccat cggcgttgcc gaggatctcc agattgaccc gccggaacgc 5641 cgcatccata cgacgggatg cccgctcgac tgcttctccg agttggtcca tgtcggacaa 5701 gaaggccagg cgcttgtccc tggccaggtc cgacagtttt ccactttggg atcgtccacc 5761 aggagcaccg agtagcccgg gaggaattgc gcatcgccga tcgccgcgaa ccccgcgttc 5821 aagcgccgta gaactgacgg gttttcgcct cgcagggcgc tcccgatccg atccgtccgc 5881 cagtcattgt ccatggccgg gaacctaccc ggtcgcgatc accaccccgc ctggggatgt 5941 cggggcatcc cgtctcaggc gatcgtctac tcgggctcac agttgccgct gtcactgccg 6001 gcttctcctg ccgatcacgg ccctctcgct tcgacggtgc aggcatcaat tgacctcccc 6061 ttctcccttc ttgggggaga ggtccggtgg ggtgtgcagg gcgtggtggc ggcggagcgc 6121 ggagagagcg gcgaagtagc cgcacatgcc gtggacgccg gggccggggg gcgtggacgc 6181 tgagcacaga tagacgcctg gcagtggtgt ggtgtagggg tcccagcgag gggttggccg 6241 ggccagtgac tgacgcagcg tcaaggcgcc tgcggagatg tctccgccga cgtagttcgg 6301 gttgtacctc tcgtactggg cggcggacag cccgcgggag gcgatgaccg tatcggtgaa 6361 gccgggggcg tactcctcga tgcgccgccg gatcaggtcg acggggtcgc gtgtgtcccc 6421 gtgaggcacg tgggcatagg cccataccgg tgtcctgtcc ccgcaggcgc gggacggatc 6481 ggtgaccgct gggtcgacca cgagcacgaa gggggtgtcg gttcggcggc cggccgcggt 6541 cgcggtctcc tgacggagga tgtccgtgcg tgtaccgccc agatgcacgg tgccggcctt 6601 gccgacgaga gggttggacc aggggatcgg agcgttgacg agaaagtccg ccttggccgc 6661 gcccgggccg tacctgtagg acctcagtgc gttgcggtag cgcgtgggca gcgtgtgccg 6721 gggtccggcc atgtcgagga agactttggg agcgacgtcc agcatgacga gggggaaggc 6781 gctgagctcg gcgaggtcct tgatggggtg accggtgtgg atggtgccgc cgtgtgcggt 6841 gatgtctgcg gccatggcgt cagcgatgcg ggcgctgcct ccctgaggga ggggccagcc 6901 gctgctgtgc gcgaggtgac ccagcagcag ggcgaccgcc gttgaggtca gcgagggcag 6961 ttttcccacg gcgtgggcgg cgactccggt cagcagggcc cgtgccgcct gcgtggtgaa 7021 gggcgtacgg gaggtggtgt gggctggaac gcgccgtgcc agcagcagcg gcgcggccag 7081 actgcggggc agagagcgct ggggggagag gaagaggccg acgacttcgt cggagcggtc 7141 ggccaggggc gccatgaggc tcgtccaccg tcgtccgtcc tggccgaggt gacgggcggt 7201 gcggtcgatg tcgcgccagg ccacggctgc tgcaccctgg ggcagggggt gggcgtaggg 7261 catgtcgggc tgcagcagtc ggacgccacg ggcgggcagt tcgaactgcc ggaagaacgc 7321 ggaggcggcg gccatcgggt gaacggcaga gcagatgtcg tgcgtcacgt cccggtcgaa 7381 cagcggcatg ctgcgaagac cgccgccaat ggtgtcggcc ttctcgaaca gcgtgacgtc 7441 gagtccggcg cgggcgaggg tgacggcggc ggccaggccg ttggggccgg tgcccacgat 7501 ggcggcggta gtcatgaacc ggcccccgca gcggtgagct gtcggctggc caggcggcgg 7561 taggtggcgt cgtgctccat cagctccgtg tgcgttcctg ttgctcgcag gcagccatct 7621 tcgatgacca ggatccggtc ggctgcgacg gcggtggaga tgcggtgcgc gatggccagg 7681 acctggcagc gcgtgccgat atcgccgatg gcgacgcgca gcgccgcttc ggagtcggag 7741 tccagatggg cggtggcctc gtctagcagc agaagatcgg gccgggtcag caacgcgcgg 7801 gcgatggcga ggcgttgtcg ctgcccaccg gacaggcctg taccgccttc gccgagttcg 7861 gtgtccagtc cgtgtgggag gcctgcgatc accccggtga gatgggcggc ctccacagca 7921 tcgaggatct cgctctgtga ggcatcgggg caggcatagg tgaggttctc gcgaacggtt 7981 ccccgcatca ggggtgcgtc ctgttccacc agggcgatgc gagagcgaag ctcgctcaga 8041 ggcatggcgg cggtgtccgt tccacggacg cggatcgtgc cctggtcagg gatgtggaag 8101 cgttcgatga gctggaagag ggtcgtcttg ccggcgcccg acgggccgac gacggcggtt 8161 acaccggccg ccggcagcga gaaggacact cccgagacgg cgggagcggt gttctcggcg 8221 taggcgaagg tgacctggtc gaactcgacg gcaggggcca tgtcgtcgcc gggcaccgag 8281 cgttgtccag agacttcctg gtcgatgtcg gccaacgcgc tgacccggtc gatcgcggcc 8341 cggccctgtt ggaattcgcc gatggccatg aacagcatga ccagcggcga caccaagtag 8401 aacaggtaca tgatgaacgc ggtgaggtcc gcgatcgcca gggcgccggt ggcggtgcgg 8461 gccatgcccc aagcgatcac cacggcgagg gacacctggg tgccgacgtt cgtgacaggc 8521 accagcaggg cggacagccg cgtcacccgg accccgctgg tacgtgcggt gtccgcgaga 8581 tcctggagac ggtcggcctc acgctgctcg gcgcgggaag ccttgacggt cgtcagcgcg 8641 ctcagggccc gcaggaggcc ggagccgaag tggccggtgt cttcccggtt catcacggcc 8701 gcagtgcgga cggcgcgggc cagggcgagt ccggcagccg aggtgatgcc aaggcatacg 8761 gcggtgacca ggagcatccg ccagtcgatc catgccattg ccgcgatgca gccgacgctg 8821 gtgaagccgg ccgtgatcat ctgtgcgacg gaggaggaca aggccacgcg ggccagagag 8881 gtgtcggaga cggtgcgagt gaatatgtcc ccgtgctcga gccggttgaa tgctcggagt 8941 tgagcatgca gaaggcggcg ggtgagcgtc cttcgcatgt cgaggacgat attttctccg 9001 gcccgcccga tgagataggc gtgggcggcg ccgagcagcg cattggctgc gaacaggccc 9061 gcgatgagag cgatgggcgg tgccacggac ttgtccgcgg cgacggcttc gatcaggtcg 9121 ccgatgagca gcggctgcgt gagggctgcc gctgtgcccg acaggccaag aagcgcaccg 9181 aggccgagga gcagccgctg ccgacggaca atgtggcgga tgttcatgcc gtcttggtgt 9241 aggtcgccag gaacatcgga tactgatcgc tgtacgggga caagtcccag ttgctgtaac 9301 gggcttcgag cgtgagcccg gcagcgacgg cgtagccgtc gacctcgtcc ggagtggtca 9361 gccgggacag ttcgttgccc acgcgtgtcg tgccgtcggc ctcgtaccag atatgggagc 9421 actgccacag gtcggagccc ggcaggagtg tggagtgggt ctgcagtccg gttcccggct 9481 ccgggtaggg cgtgaacaac gtggcgcggg cccggccctc gtgaagggcc tcgaccgcgg 9541 ggcggttgct cgtctcgatg acaagtcgtc ccatgggagc gagccgttcg gccgcccggg 9601 agatcgcggc ttgctggtcc tcggcggtga gcagcatcga cagggtgctg cacacggcat 9661 atacaaggcc gtagtgacgt gaatcggtgt agttgcgaat gtctccgtgg atgccgatga 9721 cgtcggtgcc ggcgggatcc gaagccagca gatcaagcat ctccatcgaa gaatccacac 9781 cggtgaccgg gcccaccttg cgggacaggg ggacggctat gcgcccggtc cccaccccga 9841 attcgagggt gccggccgac gggtcggggt ggagaccgct gagtatctcc gccgtagcca 9901 ccgcttccgc tcccttgggg aagatgcggt cgtaccaggg cgcgaactgg cggccgtagc 9961 caatgtcttg aacagtgctg ggcatggtat tcaacggatc ctaactggcc tgtgcgactt 10021 cggccggcac ctcgatgaac ggtgaggcga acatgtattc cggggcctgc gaggtgtcgt 10081 acccactgtg tcggacgatc aggaactgaa agccggagag ctgcggccac acgggatcgt 10141 tttcttcgat gctgcgggcc acgcatccac gcagcagggc gaactcgacc gttttttcca 10201 gttcgactct tttccctctg gcggcatcca gattgaaaca gaggtcgaag accgctttct 10261 ctccgcgccg tttcgggaac cacacggtgt ggctccagga acgcggagtg atggacgatg 10321 ccgccttcca ttccgactgc tctcctgacg tcgtcagggt gcggtagagg acgtgaaagt 10381 cgtggcgagc cggaagcggg gcgaagaacc gccagttggg gatcaggttc ccgatgaagc 10441 tcatggggcg gaggcggtcg aagactcggt tggggtgttg gctcaggagg gtggccacca 10501 gccatgcggc aagggccatc tcgataccgc gcgtcaccag atcggatgtt tcgggcgagg 10561 tgcgggggat tttacgtgtg ctgatcttca cgaggcctca cctgcttcag ctcgatctgc 10621 ttcgagactt tcgccgaact gtccgatcag atggaacacc tcctttcgga agagcagctc 10681 gtcatgcgct gtccgctcga tgacgtgcat ttcggaacgg ggtgccccgg ctgccagctc 10741 gctgtacagt tcgcgcacgg tcttgtccgt cagatgcgtg cggtcggctg acacgagaca 10801 tgtaggaaca ctgatcttcg ggagctcgcc gttatagccg agaaactctt gctgggtcgc 10861 gttccattcc ctcttcgctg cttcccagag tttccagtca cgatactgat cgagacagag 10921 tccctgtaga tccgcaggga aattcttcag ccatgccggc acctcaagca gtcctccgag 10981 gcccaaacgg agcgagaggg gcatgaggag aagattgaag gaaatatgct ctgccccttt 11041 cgcctgagcg gaagagcgca gcaactcgcc tgggtggctc ggatccagca ggcagagacc 11101 gcgaacgagg tcgcgcatct gctctgccgc gcgcagtgca agatacccgc cgagcgagtg 11161 gccgacgatc accaccggac ggctgccgca ggcatggcgg acgagctcct ccaagtccag 11221 cacggaggat cgcagggtga acggctcttt ctcgtggaac tcgctgcgtc catagccggc 11281 ccggctgtag acaagtgtcg gataattcag gccgaggttg agctccatcc aataccagta 11341 ctccgctgtt gaagccatcg cggtttcgaa caccaggacc ggggtttcgg aggaaaccgg 11401 agcagtcggc tccgtcattc tgtaggcaag gatgtttccc ttgctcgtct cgaacatcga 11461 ctcgtcgccg cggccgcgca agactcggcg gtgacgcagc gcctgggctg cgaatcccgt 11521 cacggcaacg ccggccagca ggcctgcaaa ggcgcggggg agggtgtcgt gacggctgtt 11581 cacgaagacc tccccgaggc gagggcggcc ggggccacag gtctgcgctg tgctgcgtac 11641 aggaccgcgg ggtaggtgga ggtgaaagcc cacacgaaac gaccgagacc catcactcgg 11701 gcgttggcca ggtgaaacat cccgagcgtg gcgagcatca ggggagccgg cctgcccttg 11761 gcgagaaata ccacagggaa ggcgcattcc agagccagta cgctatgggc cgtcagtttg 11821 gtcagagtgg ggtgacgctg ggccatttca taggcctttg gctcaccgaa ggactccgtc 11881 cggagaatgc cgggcagggc atcgccggat cgccagatat cgctgggcag cttggcgtat 11941 ccggcggcgg catacgacat ggtcgactga agagccacat accacaggca cgcatcgatc 12001 aatcgtggct tgccgctcgt cctcgctatc gcggctgccg cctccacgtg aaagctcagc 12061 tgatccgtgc cgtcatttcc gtacggctgt gtcagattgt tcgccatgga ggtcaacgcc 12121 agcatgctgt ttgccgcggc ccgaaggcgt cgaggtgcgc tcggggccag tagtgacgcg 12181 gcggcgagca cgcgggcgat gtgaatcgtc cgaacactac gcggatctgc gagcacatcg 12241 atcgcgcggc gaaccaacgg gtgcctcgcg gcgtgtatct cacgcacctc atcccagtga 12301 ttcaaaccgc cgggttgccg gtcccgtgcc gaggcgagat tctccaggct gtggatgagg 12361 tgagtaacgg cactcgtctg ttccatgacg gtgagggcac ggtcgcgtcc aatggaagga 12421 ggcgagacca acttgcccaa aagagaattg attctgggtt tcatatttca ccatgctttt 12481 gcgacagaat gcaccacgag gtgggccgtg cccatgagac acgggcacgg cccatttctt 12541 tcggagaaac tcaccgcggc ctttcgacct gagtgattag atcaccagat cgagtgaatc 12601 gccgtggcga ccgcgaccga ggccgcgagt gctgccgggg tgcccagaac gggaaccgtg 12661 gtctcgctca gaatctccgt ttgcgtcgac gcgatgtgaa gcgcgtcgag cctctcgtcg 12721 tggtttacga tcgaggtcag ggaatccatt tgcttacctc tctgagtgtg tctgatcgaa 12781 cccgtccgct cggtggtccg cgaagcagcg taattctgct gcaagcagga cggagggggt 12841 tatcagtggg tgagagccgc cacggcgcag tgcacggccg catgcgccgg cagcccgcaa 12901 acagccaggg ctgtgttgac ggcgtcgctg aggctgatga acatgccggg atccaggtcc 12961 ccgtggatac tttcggtgat gtccatcggc agagagccga tttcttcgga agcgttcacc 13021 atctccagca caggagacat gattaacctc ttttccgttg cgtctgcacg gaaagattcc 13081 atggaaatgg gcggcaactg gcaactggca actccgcgag tcgtcagttg agccgttccc 13141 ctctggtcag gaggggagga tcgactcggc ccatacagaa tcccccgttg atcaatagaa 13201 cattaacgcg ggcacaggga tgagtctgtg gtgtggatca cagcgacttt ggcatggggc 13261 gagagaaaga ccctcgaaag gcgctcggcg taatcctcgt caagttcttg caggtgacat 13321 gcagtccgtg cgtgtcggta gttgtgcaac tctttacagg atggccgaaa cccttgaggg 13381 cggggctgaa acgctggcct tgatcatcga agatggccgg gtgtatatgg agtgtcaccc 13441 ttgaagtggc cgccatgtcc gacaatcgaa ttgcttggtg gttcgcctgc aatgtccgcc 13501 tgtcacgcca gggcttacgt atttgccgtg cgacgccgga tggagggagt gcggaggtga 13561 ggacgcgccc cggcccggga agggcagggg cggccgtcgg cctcgtggcg tccggagccg 13621 ggccggctca gaggccgtag ctcttgccga tgatgtcccg ctggatctcg ctggtgcccc 13681 cgtagacggt ggagacgacg gcggcgcgca gatgccgttc catgccgtac tcggtggcgt 13741 agccgtagcc gcccatcatc tgcatgcact ccagcgcgac gcgcttggcc gtctcggtgg 13801 ccttgagttt ggccatcgac gcctcgcgcg ggaagagccg gtccggccgg gcgtcgcagt 13861 ccgacgccac ctcacgcacc agcagtcggg cacactcgat ctccgtggcg agatccgcca 13921 cgcggtgccg cagcgcctgg aaggagccga cgggtcggcc gaactgttcg cgctcgcgta 13981 tgtaggcgac cgcgtcgtcg aaggcgcggc ggcccagccc cagcatgttg gccgccagga 14041 agagccgctc gtggttgagc cccgccatca actggcgcca gccggagccg acttcaccga 14101 ccaccgcgtc cgggggaagc cgtacgccgg tgaggaacac gtcgttgacc tcgcggccgc 14161 ccatggtctc gatgccccgc acctccactc ccggcgtgtt catcgggacg tggaacatcg 14221 tgagcccctc gtgccggtcc ccgcccgtcc gtgccaccag caacatgctc tcggccacat 14281 gggcgttcga gatccaggtc ttctgaccct cgacgagcca actcccgtcg ggctgccgct 14341 cggcacggca gcgcagggcg gccacgtccg aaccggcgcc gggctccgac atggcgacgg 14401 ccagcacctg accacgcgcc gcgccgccga gcaccgcacg gcgctgctcc tcggtgccga 14461 aacgctcgta caccttggcg gtgatcacgg tggtgacgaa gccgccggcg ggcaccagtc 14521 cgtaggaggt ctcctccagg aagacgcagg cgtcggcgag gccgccgccc gcgccgccgt 14581 actcctcggg caggcatact ccgagccagc cgaggtcggc gagcatggcg tagatcttgg 14641 gattgtgggg ctcccggccg ccctgggtga gcgcgtcccg ctgcacggga cttccgcact 14701 cgcgctgggc gaattcacgt acggcggcgg cgaaatcgga ctgctgcggg gtgaggcgac 14761 tgcccatggg tcctccgaag acgagggaac ggcgtggtgg gacaacaagt gagatacaga 14821 tatatggtta atgtttcact gtatctatga aaggggtgcg ggtaccgtga aaggcaccat 14881 gaagacatct gcgaacgact ccctgctggc ccgggccatc gcccggccgg agacagagga 14941 aaagctggcg cggcagatcc tcgacgccgc cctggagcag ttcacgacct tcggcctgcg 15001 ccgctcctcg gtcgaggacg tcgccaaacg ggccggcgtc tcgcgcgtca cggtgtaccg 15061 ccgtttccag agcaaggacg gactggtcga ggcgtgtctg ctgcgcgagg gcagccgctt 15121 cttccaggag ctggactccg ccgtcgcctc gctgccgacg atggaggacc gggtcgtgga 15181 gggcttcgtg gtcgccctgc ggcacaccag ggcccatccg ctgttcggcg gactgctgaa 15241 gctcgaaccc gaggtggttc tgccgtactt caccgtccag ggcggcgcct ccctcgccgc 15301 caccacggac tacctgaccg cccatctgcg gcgcgcccag cacaccgagg gccgcccgga 15361 gaccgacccc cggccggtgg cggagctgat ggtgcgcgtc gcggtctcct tcctcctcaa 15421 cccggccggc tgtatcgaac tgggcgacga ggagcaggcc cgcgcgttcg cccgcagata 15481 cctcgcgccc ctgctcgacg cctgaccctg cgcccgccgt caacgccggg agtgcagcca 15541 ccgcatgagc gccacggccc tggccttcgt cgcggcgggg gtcgcgaacg acgtcagatc 15601 gaccggcggt gcgaagcgcc ggacggtcac cgactgcggg gtggtgaagg cccgcagtcc 15661 gtccgcgccg tggatccggc cgaaaccgga gtcaccggac ccgccgaacg gcagggccgg 15721 gacggcggcg aagcccagca ccgagtcgac ggagaccgcg cccgcccgca gccgggacgc 15781 cagcgcggca ccggcgcgac ggctgccgcc gaacaccgcg gcgcccagcg cgtagcgtga 15841 cgcgttcgcg cgccggaccg cctcatcctc gtccgccacg gcgttcaccg cgaccgtcgg 15901 cccgaaggtc tcctcggtca tggcgggcga gtcctcgggt acgtcgacca ggaccaccgg 15961 ctccacgaag gccccggccg ccggcgccga ttccgagccg ccgagcgccg cgcccgcccc 16021 cgccgccagc gcatcctgga catgccgccg caccaccgcc gtctggtccg gcatcgtcat 16081 aggaccgtag gccgcgtcag gaccggcgcc cgggcgcagg ccccgggccc gctcgaccac 16141 cttctcgcac agcgccgcgt gcacctgccg tacggcgtag acgcgttcga cgcccgcgca 16201 ggtctgcccg gcgttgccca tcgcacccca cacgatcgcg tcggccgcgg catccagatc 16261 cgcgcccgcc gtcacgatga ccgcgtcctt gcccccgcac tccgccagga acggcgtgag 16321 cgattcggcg cacaccgcca tcaccttgcg cgcggtcccc ggggacccgg tgaaggcgac 16381 cttgtcgact ccggagcggg ccagcgcccc accggtcgcc gcggccccgg tgacgacggt 16441 gaacagtccg gcgtacccgg gcacggccgc gtcgaacagc tcggcgagca gcacccctgt 16501 accgggggtg tactcggagg gcttgaagac cacggcgtta ccggccgcca gggcgtagcc 16561 gatggatccc atcggcgtgt acacggggta gttccagggg ccgatcaccc cgacgacgcc 16621 gagcggacgg cggaccacgg tcgccgcctg gtgcatcgcc accgccccgg agcgcaccct 16681 gcgccggcgc agcacgcgcc cggcgttgcg ggccgcccac gacaagtgct ccagggtgag 16741 caggagttcc agttcggcgt cctggcgggg tttgccggtc tccgccgcga cgatccccgc 16801 cacggtgtcc agggacgacg ccaactcccg cttccagcgc agcagatgtc cgcgccgctt 16861 accggcggac agggccgccc agcgggtccc ggccgcccgc gcccgccgca cggcacggtc 16921 gacgtccagc ggcccgtgga cggggtacgc ggcgagggcc tcaccggtga cgggggagcg 16981 ggaggtgaag ctgccgggcg gggaagtgcg tcgctcgacg gaatctgccc gcgtgccgtc 17041 cgcggtggaa ccgggttcgg tgggtgcggc ggtgtcggtg gaaccgggtg ccgtgggtcc 17101 ggacgtgtcc gtgggagccg gttccgtgag cccggaggtg tcggcggcgg cgggttccgt 17161 gtgcccggcg ggaccggtgg tggcgggatc cggctgtccg gcggtgtcgg tggagcccgg 17221 tcccgtggct ccgccgggtc ggtcggcgtt ctcggtggtg tgggtcatcg gcgctccatc 17281 ggtgggttct cgtcggcgag cggggtcggt ggcctgtggt gggcccagtg cgggccgagg 17341 tcgtcgagcg tccagccgaa ggggtagctg cggggtttgg gccggctcgg ccaccagccg 17401 ggccgggcgg gcaagtggcg ggtcagcagg gcacgggtcc gcaggaggac gtgggccgcc 17461 gtgcgtaccg ggcgcggctg cgggcggaag ccgagcgcgg tcagcagcgt ttcgtccagg 17521 acggccaggg cgaggcgggc cacgagcggt cgcagtggcc gcgggtacca gtcggtgatg 17581 atccgcaggg tggccgcggc gacccgccgg ttggcggggt cgtacgcgaa catctccttc 17641 tcgtaggtgt cgtggagctg ttcgaacccg gcgtagtcgg cggggagatc ggtgatcccc 17701 atcatctcgc ccatgcgccg accgaccagg gccagactct cggcctcctg cgggcacagc 17761 ggccgccagc cgtaccggtc gatccaccgc ttgggtccga ccacggtcgt cgccaggacg 17821 tacaggtagt cctcgttcgg tatgcggtaa cggccgtgga tgcggttgag gtgacgggcg 17881 gtggcccggc cgtgcgggga gtccatgccg tggcggacca tctcgtacgc gatcagcacc 17941 gtgtcgtcgt agcgcttctg tcccgcgcgc tcgaactcct gcgttcggtc gaggagttga 18001 gagatgcggg gcacgccgta gtcgcgcagg aaggcgacgg acacaccctg catgtagtcc 18061 caggggaact cgtaccgggt gatccaccgg aagatctcct cgtggtcgtg ccggggatcc 18121 atccggcgga tccgttcgag ccggctgtag cggcccatgg gtgatgcctc ctatcggctg 18181 tcgggctggc ggcctatcgg gctgtcgggc tatcgggtgt gactgtgcgc gctcaggccg 18241 gagaagttga ccgtctcggc gtcgaccagc acctggccgg cctccaccgc cgtgaccgac 18301 agctcgggca gctgaacggc gatcggcagg ttcgccggca cgacgtcggc gccgatgcag 18361 atgcgcgggg tggcgacgtc gatgacgggg atggtgaggg agccggagag ccgggtgacg 18421 tagatgtcga cctgcgggat gtcgaggtcc acgtcgatcg tctgcacctg gcccggcgtc 18481 tccagacgga aggtgtagtc gtccgcgacg agccggtccg cgtgcaccca gagcaccttg 18541 agctgcccgc cgccgaccgt cccgagatag gtggcgccgt ggacgatggc cccgtaggcg 18601 gtcaggctgt ccgcaccgac ctggggatag acggtgttga ccgggtaggc cgcgcgggga 18661 cggcccggct ggtccccgac gacgacgggc gggcgcaggg ccgtcaggtc gtcggggtcc 18721 gcgggcatct cgcccggctc ggggttgggc agtccgccgg tgtcgacgcc ggtcaggcac 18781 gggagggtga cctgggggcc caggacggct ccgggccggt ccgcgggccc ttcggtgccg 18841 gctccgtcgt ccggaccgcc gccctggtcg gcgtcgcccc ccgacgagtc cggggccgag 18901 tccgagcccg ccgaagggct cgcgttcggg cccgcggaag ggcccgtgga cgggccgggg 18961 gtggcgccgg gggaggcgga tcccgtgggg gaggggccgg cctcggccgc cggggactcc 19021 gacggagtcg cggacggcgc tgtggacgag gtgtcgcccg acccccactc ccatggccag 19081 ccgttcgtcg gccagggcag cgggaacagg ccggtgccgg ggtgcgccgc ggcgccggtg 19141 gcacccggga gcatcgcggc cgccagcgcc gtggtcagga cgaagaggac cgcgccccgc 19201 gcaccggccc ggcgcccgcg gtaccgggct cggccctcat cggcttttgg gcggccgctc 19261 gctccgtccc cggcggccgg ggcatcggcg gtccgctccg caccggctgt cgcgcccgta 19321 gtccgctccg ctcgggctgc cgcgcccgcg ggctgcgcgg aggccggctg cgtggaggca 19381 ggccgtgcgg aggcggggcc ttgaggcgtt tgcggttctc gggggccttc ctcggggtgc 19441 cggttgcccg gcatccagcc gaaggccatg gaggagccga tgaggcccgc cagcatgccg 19501 atgccgaaac cgcccaggtt cgtcgtcgcc atcgaggtca gggacgcgac ggccgtgacg 19561 accgagacga acatgcgctg gtcgggcttg aagaggaaga agatcccgcc cgcgacgagg 19621 accacggcga taccggcggc cgacatcgcg cccaccccga ccctgatcat cagtggcagc 19681 ggggcgagcg ggatggcgac catctcgatt ccgcccgcga tcacccacac cgccgcccag 19741 aacggacgtc tcctgcgcca ggcgcgcagc gagcggcgaa cccgccgcgc gggcaggacc 19801 cggtcgatcc agtccccggt ctcccgggcc agctccgaca ggaagccgag aacgaaagcg 19861 aacatgcccg aacccgtctc tcggcgccgt cagaagcact gcttgccgga acggctgaac 19921 tcgatctcca gcttctccag cgtcagcgtg ccgccgttgg ccgagtaggc ggtgctccgc 19981 aggtcatggg cgaccgcggt gtccgcctgc actccgaaca cgcccttcgg cccggtcacg 20041 cccggcgcgc cggtcagggt ggacgcgtcc cggccggcct gtacaccggt gacctttccg 20101 ccgcccccgg tgagcgcgtc ggcgttcacc acgaggttgg tgcccgcgag cggcttgtcc 20161 gcgcccgagt gcaccagcat ggagatctct ccgaccagcg gaagcttctg cttgagcgag 20221 acgcacacgt cggagacggt gccgtccttg acggccgcga gcaggaccgg cctggcgtcg 20281 tcggccgagc cgccgatgga ggaggggaag gacgacacgc cctgcgcggt gacctccgag 20341 gcggacacct tgaacgccgt gccggatacg gcgaacgagg cggcgatcgc cccttccgcg 20401 agcgcgatgc ccagcgcgcc caccgccagg gtgcagggga cgaacatcag ggcgctgcgc 20461 cgccagtgcg tccgaccctc gtccgcgttt ccgatatgtg catatctgtc cctcacggtg 20521 ttttccttac ctttaggggt gaatgccggg atcccgcgtc ggggtgtcgt cgagagagtc 20581 gaagatacaa a //