LOCUS       NZ_LMEQ01000030        22628 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root1310 contig_4, whole genome shotgun sequence.
ACCESSION   NZ_LMEQ01000030
VERSION     NZ_LMEQ01000030.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1310
  ORGANISM  Streptomyces sp. Root1310
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 787452)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 787452)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1310
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426425.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 02:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,470
            CDSs (total)                      :: 8,385
            Genes (coding)                    :: 8,123
            CDSs (with protein)               :: 8,123
            Genes (RNA)                       :: 85
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 262
            CDSs (without protein)            :: 262
            Pseudo Genes (ambiguous residues) :: 0 of 262
            Pseudo Genes (frameshifted)       :: 98 of 262
            Pseudo Genes (incomplete)         :: 219 of 262
            Pseudo Genes (internal stop)      :: 20 of 262
            Pseudo Genes (multiple problems)  :: 64 of 262
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 237388
            Orig. end                         :: 260016
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEQ01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22628
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22628
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22628
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12628](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12628
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            77..1114
                     /locus_tag="ASD48_RS28290"
                     /old_locus_tag="ASD48_18695"
     CDS             77..1114
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021599.4"
                     /locus_tag="ASD48_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18695"
                     /product="DUF2332 domain-containing protein"
                     /protein_id="WP_199875993.1"
                     /transl_table=11
                     /translation="MYRHFGEVDAAGTSPLYERVAVALSESDEALDAIRTAPARKRHPA
                     LILAALHDLALAGRAPALAAAYASADGDAAADAAIDTLLRMTGPVVAIAARRQTRADET
                     GRSAVLYPAIAEAARRVGAHTVGLIDVGRSAALNLQVDRVGISYGDGRSLGDPSSPVQL
                     SSSVVGDRPVPTRAMPEVVARVGVDLDPVDVTDTDDARWLRACLPPDQPERAARLEAEM
                     ALAATAPPLLLRGDAVEVLPDALARVPADVLPVVTTTWALSRFPLESRPRFLHRLCEAA
                     VDRPVAWVSAEGVGVAPTVPTLGDRRASGHSIIGLVVLDGPAVRSEAVGRCWSRGRLLA
                     WLAGS"
     gene            1260..2453
                     /locus_tag="ASD48_RS28295"
                     /old_locus_tag="ASD48_18700"
     CDS             1260..2453
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127254.1"
                     /locus_tag="ASD48_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18700"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_057604567.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.6e-24, bitscore:
                     81.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.7e-22, bitscore:
                     74.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.1e-27, bitscore:
                     90.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLTEQQNLADFYDFESALTEEERKVLLRTRAFMRDEVQPLVAE
                     HWADGTFPMELISRFRESGLVGLSYEGYGDHGPAAGHLLTGMMAMEMSRVDASVATFFG
                     VHNGLAMYAIHACGDQAQRDRWLPGMARMDTIGAFALTEPLDGSDIAAGMQTTARRDGD
                     TWVLDGAKRWIGNATFADHVVVWARDVDDDQVKGFVVDKGTPGFKAEKIAHKTSLRIVE
                     NADVTLTDVRVPESDRLQNASSFRDVAEVLRATRSGVAWQALGVMIGAYELALRYATQR
                     QQFGRPLAGFQLVQDLLVKSLGNITSSWGMLHRLAALQDAGVFRDEHSSLAKAHVTARM
                     REVVAWSREIFGGNGIVLEYDVARFFADAEAIYSFEGTREMNTLIVGKAITGQSAFV"
     misc_feature    2500..2511
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     gene            2595..3095
                     /locus_tag="ASD48_RS28300"
                     /old_locus_tag="ASD48_18705"
     CDS             2595..3095
                     /GO_function="GO:0043169 - cation binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328128.1"
                     /locus_tag="ASD48_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18705"
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_057605025.1"
                     /transl_table=11
                     /translation="MPDTPDTRDVVALILEDHRRMEDLFRLMRSVEADRAAALREFADL
                     LIAHALAEEAKVYPALKRFKKIEDEEVEHGEEEHEEGNKALLELLEVDEVGSDEWDEKL
                     EELVEAIAHHTDEEERTILNGARENVAMERREELGEAFLEERGRQLKAGCGAVENVRRI
                     VGS"
     misc_feature    complement(2626..2639)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.26"
                     /tool="antismash"
     gene            complement(3504..4604)
                     /locus_tag="ASD48_RS28305"
                     /old_locus_tag="ASD48_18710"
     CDS             complement(3504..4604)
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127256.1"
                     /locus_tag="ASD48_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18710"
                     /product="AI-2E family transporter"
                     /protein_id="WP_057604568.1"
                     /transl_table=11
                     /translation="MPTPPDQPALPLERPGSGEPHVPGLLRTAAAYAWRIIAVGVVVHV
                     TFSVLGQFHRIAVAVFLGLVITAVLRPVAGLLARFMPRPLAVAVALIGGIVLVLGALAL
                     VGETAADQRSGLEKEFVTGIDRIERQLEEPPFRLPPDAFDDLQSRIGKLLSSHRSTLIS
                     TALSGASRLIEVLTVLALAVFCAVFFTYSGDRQWQWVCDQLHEGARRQVTVAGRAAWRT
                     FTGYTHGILLVAATNAVLVGIALFALGVPLAVPLALLEFLAAFIPLIGSPIALAIAAVV
                     ALASKGAVIALVVVALIVVIGQIEGHLLHPLVMSWAVRLHPVVVALAVVGGAVAAGVIG
                     AVVAVPLVAVVWSVYQALRTRADGPE"
     gene            complement(4686..4826)
                     /locus_tag="ASD48_RS45020"
     CDS             complement(4686..4826)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS45020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_206780420.1"
                     /transl_table=11
                     /translation="MKGSDATVAAVGTVAAVGAVGAVGAVGAAEDLAQGAVRQDAVIRP
                     R"
     gene            complement(4971..5249)
                     /locus_tag="ASD48_RS28310"
                     /old_locus_tag="ASD48_18715"
     CDS             complement(4971..5249)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044103.1"
                     /locus_tag="ASD48_RS28310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18715"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_057604569.1"
                     /transl_table=11
                     /translation="MGIIAWIVIGLLAGAIAKALMPGKDPGGIIITMLIGIAGGLLGGW
                     LGKVIFGVDSIDGFFDLSTWIAAIVGSFILLALYRLVTGNRRSHRHA"
     gene            complement(5603..6979)
                     /locus_tag="ASD48_RS28315"
                     /old_locus_tag="ASD48_18720"
     CDS             complement(5603..6979)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570592.1"
                     /locus_tag="ASD48_RS28315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18720"
                     /product="MFS transporter"
                     /protein_id="WP_057604570.1"
                     /transl_table=11
                     /translation="MPSATVASPPPSLPTVPKNATVPENATTTDPALVKRAVRAAALGN
                     AMEWFDFGVYSYIAVTLGKVFFPSGNPTTQLLSTFGAFAAAFLVRPIGGMVFGPLGDRV
                     GRQKVLALTMILMAAGTFAIGLIPSYASIGVGAPVLLLAARLVQGFSTGGEYAGASTFI
                     AEYAPDKRRGFLGSWLEFGTLAGYIGGAGLVTVMTALLSTEDLLSWGWRIPFLIAGPMG
                     IVGLYLRMRLEETPAFAAEIEKAESNRPKVPLRRMVVGQWRALLLCVGLVLVFNVTDYM
                     LLSYMPSYLTGELHYDETHGLLVVLGVMAVMMIVQPFAGALTDRVGRRPVIAAGCAGFL
                     LLSVPALLLIRQGSLFAVALGMGALGLLLVCFTAAMPAALPALFPTKVRYGSLSIGFNV
                     SVSLFGGTTPLVVTALIGATGNMMMPAYYMMAAAVIGGVAVWFMAESAGRPLPGSAPSL
                     "
     misc_feature    7341..7350
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    7367..7380
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.85"
                     /tool="antismash"
     gene            7370..8272
                     /locus_tag="ASD48_RS28320"
                     /old_locus_tag="ASD48_18725"
     CDS             7370..8272
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127259.1"
                     /locus_tag="ASD48_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18725"
                     /product="NAD-dependent protein deacetylase"
                     /protein_id="WP_057604571.1"
                     /transl_table=11
                     /translation="MRMRPTLSWTPAEDLPPGTTDPERVVDALGAGGVLVLSGAGISTE
                     SGIPDYRGEGGSLSRHTPMTYQDFTSDARARRRYWARSHLGWRTFGRARPNAGHRAVAA
                     FARHGLLSGLITQNVDGLHQAAGSEDVVELHGSLGRVVCLSCGAFSPRHELARRLAEAN
                     ADFEPVAAAINPDGDADLTDEQVGDFRVLPCTVCGGILKPDVVFFGETVPPPRVEHCRA
                     LVREAASLLVLGSSLTVMSGLRFVRQAGQAGKPVLIVNRDPTRGDQHAVTRVALPLGPT
                     LTTVAARLGIPLDEQGAPA"
     gene            complement(8323..9564)
                     /locus_tag="ASD48_RS28325"
                     /old_locus_tag="ASD48_18730"
     CDS             complement(8323..9564)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127260.1"
                     /locus_tag="ASD48_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18730"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_057604572.1"
                     /transl_table=11
                     /translation="MTATERSSDVVVIGAGVAGLACAQDLLAAGVGVRILEASDEVGGR
                     MRSDRVDGFVIDRGFQVFNPSYPQVRRRLTGDGLDLRPFDRGVLIHTDKGRRRLTDPRA
                     HPSTLVDLLSGRLAGPRDLAALGALAASDAVAPPHRLKRRPDRSTRQALADAGFTDAFV
                     ERFFLPFLSGVFLEDRLETSARVFHLVWRSMLRGTQSLPAAGIGAVPLALAASLPKGTV
                     RRETPVGRLTDDGVETTARELVPARAVVVATGPGPAGTLLPGVTVPAYRAVTTYYHAMP
                     GPPLDEPTLLVDTRRRFLNTCVLSNVAASYAPDGRALVATSVLGADTEGRERALRAALS
                     EVYDTDADRWDLLTVRTVPDALPAMAPPQELSRTTRVARGRYVCGDHRATGSVQGAMAS
                     GARAAREVLRDLGR"
     gene            10001..12628
                     /gene="lanKC"
                     /locus_tag="ASD48_RS28330"
                     /old_locus_tag="ASD48_18735"
     CDS             10001..12628
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127261.1"
                     /locus_tag="ASD48_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18735"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_057604573.1"
                     /sec_met_domain="micKC (E-value: 3.9e-278, bitscore: 920.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.1e-10, bitscore: 35.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-16, bitscore:
                     55.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYEAFSYADKVFYDSPVRWAAVEEFAAVGEPLPDGWLASAREVW
                     VGRRPADVELPDQGWKIHVSACLDNAEHILSVVGSYCFEQRVAHKFLRSPALVQTQNAK
                     YASRGSSGKFMTLYPVDEPELERCLTDLDEALAGLRGPYILSDLRWRNGPLYLRYGGFT
                     EQFCRSETGELVLALREPSGRLRPDVRRAVFEVPEWAPVPAVLAQALTDRAATSTADFP
                     YTVERALHFSNGGGIYIARPATGGDQVVLKEARPDAGLDQRGDDAVLRLGREHDILRRL
                     EGVPVVPAALGRLTAWEHHFLVQEYVPGEPLNRWFGRRYPLVHPDPDRETIDRYREEAL
                     TVLAGVEEGLRAIHARGVVFGDLHPRNLIVRPDGRVCFVDFELASPADAFVRPALGAAG
                     FAAPPDLEGYAIDTYALDALRLWIFMPLLQLTSLDPGKRDELTDAAARRFGLPARPADG
                     RPPAPPQAPPPALSQAPPPAPPSVPPADPRERAAPATLFSGDRADWPALRDSLVAAINA
                     SATPERTDRLFPGDPSQFTHDGLGLAYGAAGVLWALHTVGAPVDPDHVEWLGEAVAREP
                     CRPGLYTGAHGVAFALDRLGHTRQAHNLLDRLLKDPLDAQGSDLAGGLPGIGLTLLHFA
                     GTTADASLHAVAVDVAERLAARLKPDSGKAGPAPARRPGLLHGASGAALFFLSLHDSTG
                     DAGLLDLAEHALDLDLARCVLGDDGTLQVDDGSRVLPYLESGSAGIAAPLHALLRHRPD
                     PQRRRSLEQIRGAAEPEFIVQSGLFNGRAGLILLLRLLQDDTTLHDQVIRRHIRRLVWH
                     LVPYQGHAAFPGEQLLRLSMDLATGSAGVLLALGSALADTPALPFWNGRGAAAPASLAL
                     PKAS"
     misc_feature    10097..10099
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12729..12854
                     /locus_tag="ASD48_RS43705"
     CDS             12729..12854
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998309.1"
                     /locus_tag="ASD48_RS43705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_020127262.1"
                     /transl_table=11
                     /translation="MSILSLQALETPEETTEYLSVLSSLSAVNCTNSTVSTLLCL"
     CDS_motif       12729..12788
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSILSLQALETPEETTEYLS"
                     /locus_tag="ASD48_RS43705_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12789..12854
                     /prepeptide="core"
                     /locus_tag="ASD48_RS43705_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.10"
                     /molecular_weight="1981.3"
                     /monoisotopic_mass="1980.1"
                     /core_sequence="VLSSLSAVNCTNSTVSTLLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSILSLQALETPEETTEYLS"
                     /leader_location="[12728:12788](+)"
                     /alternative_weights="1999.3"
                     /alternative_weights="2017.3"
                     /alternative_weights="2035.4"
                     /alternative_weights="2053.4"
                     /alternative_weights="2071.4"
                     /alternative_weights="2089.4"
     gene            13144..14760
                     /locus_tag="ASD48_RS28335"
                     /old_locus_tag="ASD48_18740"
     CDS             13144..14760
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127263.1"
                     /locus_tag="ASD48_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18740"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242432756.1"
                     /transl_table=11
                     /translation="MATSSVAALVLPAALAAAVDRALSGDAGAGVAPLAAVLCLLTAAE
                     TLAQYAGPRATAEATARLRAALIRHIMAVGPYPARRTATGDLVARITASAAEAGLSVQA
                     AVYAVAQLAMAAGSVLALGLLAPELAAAFGITAPVGWLLLRRHLRRTVRRGEGYQAAQA
                     AVAARLLDALAGHRTIAAAGTVEREIERVLAPVPELSRHGRALWDSQRRVAWSTGLLAP
                     ATQITVIAVAGYELSTGALGAGGLVAALGYATLGLGGFGTAQSLLDHARARAGRRRVHE
                     VLAPPRQPPGLRGLPPGPGHVELHAVTVRRAGCTVLDALDLTLPAGRCVALVGRSGAGT
                     SLLAAVAGGLLAPERGTVLLDGVPMDEIRPADLRAAVAYAFSDPRLTGATVLDALRVAA
                     EPLPEARVRAAARAAQADVFIRRLPAGYLTPVRDAPLSGGQRQRLGLARALARDGRLLV
                     LDDATSSLDSATEAAVLRAIDDTHAHRTRLVVTRRTATAARADLVVWLHEGRVRALAPH
                     HELWRLPAYRGMFRGAGDAQG"
     gene            14792..16966
                     /locus_tag="ASD48_RS46055"
                     /old_locus_tag="ASD48_18745"
     CDS             14792..16966
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127264.1"
                     /locus_tag="ASD48_RS46055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18745"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_282438351.1"
                     /transl_table=11
                     /translation="MAEHTARPPRPTPRPAARSLTAANGTALRLIRGGLADNRAAALRL
                     TWWTLLSAAPALVCGKALALAVDRGFLLDRPRTAALGLGLFALCTLGGAWASRQTYPWL
                     AEIVEPLRDRLLRDVVTGTLHRAVTPGAARDDCAAVAVARLTRQVETVRDALAGQLMLL
                     WQFVLTVAAVVTGTAVLAPAAVPLVAGPLLVALALFAVLAPATVRRQRAAFDAEEALAG
                     RAVETVEALRDIVACGAHEHAQREALDAVRRHLRASRALASVSALRRLIVALGAHSPLL
                     LVVLAAPVLLAHGMTAGEIVGVLAYVLATLEPAIRLLVQGLGASWLRLAVAAERLADAA
                     RRPEPRPDPRPALRPADGSATLSGVAFAYGPEAEPVLDGLDLSLADGDHLVVVGPSGIG
                     KSTLADLLTGMLTPHRGRILLGGVPLDRIARQDLAHARVLLPQTPYVFAGTLRENLCHL
                     APGTPDGVLAEAVAELGMSALVERLGGPGGRVDPAGLSSGERELVALARAYVSTARLVV
                     LDEATGHLDAAAERQVEEAFRRRPGTVVTIAHRISSARSADQVLLLDGGRPRVGTHRTL
                     LAQVPLYADLMGHWRTGATEDGRPGDAHPGDAHVRDSRAREAHARDCHAGDAHVRDSHA
                     REALVGDGHPGDGHARDAHLMNAHAKDGHPRDAHPGDAHVRDSRAGNAHAGDGRPGDSP
                     ARGDRAVARLNSPDAASDRSSSRPVADPAP"
     gene            complement(16902..17591)
                     /locus_tag="ASD48_RS28345"
                     /old_locus_tag="ASD48_18750"
     CDS             complement(16902..17591)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-162). E-value: 1e-12. Score:
                     40.2. Matches aSDomain:
                     nrpspksdomains_ASD48_RS28345_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127265.1"
                     /locus_tag="ASD48_RS28345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18750"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_057604575.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-30, bitscore:
                     102.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVHLITGAGSGIGAALAALFASRGQELWLLARDEARAGELRARF
                     PRSRTLVADLSVPGAIRARLEAQALPGRLDSLLHVAGVAESGRVGELSAEVWQDTLAVN
                     LIAPAELTGLLLPALRESRGHVVFVNSGAGVHAPPRLSAYAASKFGLKALAESLRAEEF
                     AHGVRVTTVYPGETDTPMQVRLHGQFGLPYVPEAHMSPTSVAAAVVTALDLPRDATMSD
                     LMLRPGC"
     aSDomain        complement(17106..17588)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS28345_PKS_KR.1"
                     /evalue="1.00E-12"
                     /label="ASD48_RS28345_PKS_KR.1"
                     /locus_tag="ASD48_RS28345"
                     /protein_end="162"
                     /protein_start="1"
                     /score="40.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GVHLITGAGSGIGAALAALFASRGQELWLLARDEARAGELRARFP
                     RSRTLVADLSVPGAIRARLEAQALPGRLDSLLHVAGVAESGRVGELSAEVWQDTLAVNL
                     IAPAELTGLLLPALRESRGHVVFVNSGAGVHAPPRLSAYAASKFGLKALAESLRAEE"
     CDS_motif       complement(17514..17585)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS28345_0001"
                     /evalue="8.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASD48_RS28345"
                     /protein_end="26"
                     /protein_start="2"
                     /score="15.3"
                     /tool="antismash"
                     /translation="VHLITGAGSGIGAALAALFASRGQ"
     misc_feature    17598..17613
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            complement(17680..18132)
                     /locus_tag="ASD48_RS28350"
                     /old_locus_tag="ASD48_18755"
     CDS             complement(17680..18132)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676626.1"
                     /locus_tag="ASD48_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18755"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_057604576.1"
                     /transl_table=11
                     /translation="MHTEPRSHAQRRHDTEHRLTHDVDVWVASASADGAPYLVPLSFDW
                     DGEALLAATPTNSPTGRNLAASRVVRLALGRTRDVTMIDGEVDVLELDALPRERGDRFA
                     ERTGFDPRASATSYRWFRIVPRRIQAWREENELSDRELMRDGRWLT"
     misc_feature    complement(18297..18311)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            18318..21110
                     /locus_tag="ASD48_RS46060"
                     /old_locus_tag="ASD48_18760"
     CDS             18318..21110
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643532.1"
                     /locus_tag="ASD48_RS46060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18760"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_057604577.1"
                     /transl_table=11
                     /translation="MIGSEISAREAQVLALLGEHLSNAEIAARLVISVRTVESHVSSLL
                     RKLQLPDRRALARHAAEFARTEPSVAAPALPAPLTAFVGRVAERGQLAEAVKAHQLVTV
                     VGPGGVGKTRLVLAVAAEMADDFADGVWFVDLVPVTEPGRVGAAVAAAVGVGEQPGRGI
                     DEAVLAALTDRRALLVLDNCERVSDAVAPFLERLLAVCPRLRVLVTSRARLMVPFERVF
                     QVPPLSRAGGDRSEAVALFMDRASAVGQPPGPASNEEVVTICERLGGMALAIELAAARW
                     STLGLDGLTAGLSDPLRILTGGPRADDRHRSVRAVLDWSHDLLEPQSRALLRRVSVFVA
                     PFTAEAAAEVAGFAPLDPAAVVDGLGRLAEQSLLAVTSSATGTRYHALETIRQYGTERL
                     TGADELVQVRSRHLDWCSTGARALVGASGADWRARFEAVADDLRAALTWASDRPDRRAD
                     ARRLALSLAELAFFRNLLGESQQRYEQAAGLSDDADGAAALRQAAAVAGCRRLGDEMFR
                     LRRAAADAARRAGDTAGAGGDLAAAATDAYRFSSTFAQVPSREEVTALLAAAQELAGDA
                     PAARAAVALAEAAVVADAFGAVQGELDNTVEETVVRAERAVDLARCAGDPVAESAALDA
                     LSGARAWTGEAFAAASAARRRIDVLDSAPRTPAGAHELMDALAMAAGTAVGVGRLPEAR
                     RWGGQLADHPLLAEVGHHATSWLLVADAFAGRADQVLTGSARFLDAWERSGRQRSFSLG
                     PAAAAVAMVHGLRGDHDGRDTWRAIVDRAGNAPEHRHGYGAVFDAMVLLHDGDADAAAR
                     RLAPEPDQVWKWVSWVWLHWYVALRAEAAVLTGHPDARARIDAARTVVAGNPVATAQVD
                     RAQALLDGDPARQLAAAAAFDAADCPYQSARTLLLAGGEHAAVGTSVLAGLGLAPLAVR
                     "
     gene            complement(21227..21679)
                     /locus_tag="ASD48_RS28360"
                     /old_locus_tag="ASD48_18765"
     CDS             complement(21227..21679)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127268.1"
                     /locus_tag="ASD48_RS28360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18765"
                     /product="DUF1801 domain-containing protein"
                     /protein_id="WP_057604578.1"
                     /transl_table=11
                     /translation="MSSTDGSTYEGFTAEERAAMKEHAEGQKKAARRGSRADKAAEAER
                     DVLTKIAEMQDSDRTMAELVHAVVTANAPSLAPKLWYGMPAYALDGKVVCFFQSAAKFK
                     SRYATLGFNDTAKLDEGTMWATAFALTEVTAEVEARIAALVKQAVS"
     gene            <21810..21992
                     /locus_tag="ASD48_RS28365"
                     /old_locus_tag="ASD48_18770"
                     /pseudo=""
     CDS             <21810..21992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137253.1"
                     /locus_tag="ASD48_RS28365"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18770"
                     /product="cupin"
                     /pseudo=""
                     /transl_table=11
                     /translation="EVGTRLRTSPGDQVFVLPSVPYREENPDPAEEAVVVIARSTREAI
                     VVDLPHLYVPGRERD"
     gene            complement(22024..22536)
                     /locus_tag="ASD48_RS28370"
                     /old_locus_tag="ASD48_18775"
     CDS             complement(22024..22536)
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127283.1"
                     /locus_tag="ASD48_RS28370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_18775"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_057604579.1"
                     /transl_table=11
                     /translation="MEYPDLTALPAELREAVAARGSLNVFRMIMHSPRLAPGLLETADA
                     ILQRNALPDGLRELAIVRVGRVYRAPYEVHHHENIGRLVGLSRAALAAAATGSTEGLSD
                     AEASVLRCTDRLLARHTLSDAERAEVLEFLTVGQLSDLVITVGFYQLVSNFLNTFGVTT
                     EGETSPY"
ORIGIN
        1 aggatcatcc ggatgccggg accgaccgcg ggaagcgcgg gccgcggccg tgggtaggac
       61 caggacactc gctcaggtgt accggcactt cggtgaggtc gacgccgccg ggacatcgcc
      121 gctgtacgag cgcgtcgccg tcgccctgag cgagtccgac gaggcgctgg acgccatccg
      181 gacagcaccg gcgcgcaagc ggcaccccgc actgatcctc gccgcgctgc acgacctcgc
      241 cctcgccgga cgcgccccgg cgctcgccgc ggcctacgcg tcggcggacg gcgacgccgc
      301 cgccgacgcg gcgatcgaca cgctgctgcg catgaccggc ccggtcgtgg cgatcgccgc
      361 gcgccggcag acgcgggccg acgagaccgg acgctccgcg gtgctgtatc cggccatcgc
      421 cgaggcggcc cgccgggtag gggcgcacac ggtgggtctg atcgacgtgg gccgctcggc
      481 cgccctgaat ctgcaggtcg atcgcgtcgg catctcgtac ggcgacggac gctcgctggg
      541 cgacccgtcg tcccccgtcc agctgtcgtc gtcggtcgtg ggagaccggc ccgtcccgac
      601 acgggcgatg cccgaggtcg tcgcccgcgt cggcgtcgac ctcgatccgg tcgacgtgac
      661 ggacacggac gacgcccgat ggctgcgcgc ctgcctcccg cccgatcaac cggagcgggc
      721 cgcgaggctc gaagccgaga tggcgttggc ggcgacagcc cctccgctgc tgctgcgagg
      781 cgacgccgtc gaggtgctgc ccgacgccct cgcccgggtg cccgcggacg ttctgccggt
      841 cgtcaccacg acgtgggccc tgtcgcggtt cccgctcgag agccgtccgc gcttcctgca
      901 ccggctctgc gaggcggcgg tcgaccggcc ggtggcgtgg gtgtcggcgg aaggggtcgg
      961 agtcgcgccg acggtaccga cgctcggcga ccgccgcgcc tccggtcaca gcatcatcgg
     1021 cctggtcgtc ctcgacggac cggccgtgcg ctccgaggcc gtcggccgct gctggtcgcg
     1081 cggtcgcctg ctggcgtggc tggcggggtc ctgatttcgg gcgctcggac cgcaaaccga
     1141 aggcgacacc tgaacggctc cggatgagcg cccggcggtg ttgcggccca ggcccgacgc
     1201 ccgtgggcga cgacgtccgc agcgtgcatt gctcggcaca accgtggaag aagggcccca
     1261 tgacttcact cacggaacag cagaacctgg ccgacttcta cgacttcgag tccgctctca
     1321 cggaggagga gcgcaaggtc ctgctcagga cgagggcgtt catgcgcgac gaggtccagc
     1381 ccctcgtggc cgagcactgg gccgacggca ccttccccat ggagctgatc agtcgtttcc
     1441 gagagagtgg actggtcgga ctgtcgtacg aaggctatgg cgaccacgga cccgccgccg
     1501 gccatctgct gaccgggatg atggcgatgg agatgagccg ggtcgacgct tcggtcgcca
     1561 ccttcttcgg cgtccacaac ggactcgcca tgtacgcgat ccacgcctgc ggcgaccagg
     1621 cccagcgcga ccgctggctg cccggcatgg cgaggatgga caccatcggg gcgttcgccc
     1681 tcacggagcc gctcgacggc tccgacatcg cggccggcat gcagaccacc gcccggcggg
     1741 acggcgacac ctgggtgctc gacggcgcca agcgctggat cggcaacgcc accttcgccg
     1801 accacgtcgt cgtctgggcc cgcgatgtcg acgacgacca ggtcaaggga ttcgtcgtag
     1861 acaagggcac accgggattc aaggcggaga agatcgccca caagacgtcg ctgcgcatcg
     1921 tcgagaacgc ggacgtcacg ctcaccgacg tccgggtgcc ggaaagcgac cggcttcaga
     1981 acgcgtcctc cttccgtgac gtcgcggagg tcctgcgcgc cacgcgcagt ggagtcgcct
     2041 ggcaggccct cggtgtcatg atcggcgcgt acgagctggc gctgcgctac gccacgcaga
     2101 ggcagcagtt cggccgtccg ctcgcgggct tccagctcgt gcaggacctc ctggtgaaga
     2161 gcttgggcaa catcacttcg agctggggca tgctgcaccg gctcgccgcg ttgcaggacg
     2221 cgggggtgtt ccgggacgag cactcgtccc tggccaaggc ccacgtcacc gcccgtatgc
     2281 gcgaggtcgt cgcctggtcc cgggagatct tcgggggcaa cggcatcgtc ctggagtacg
     2341 acgtggcgcg cttcttcgcg gatgcggagg ccatctactc gttcgaaggc accagggaga
     2401 tgaacacgct gatcgtcggg aaggcgatca ccgggcagag cgccttcgtc tgatcggccg
     2461 ggggagcggc gccgaggacg catcggcgca gggatcggtg aaaacgttca gggatcggtg
     2521 aaaacggccg gtcggggtac tcggatctgc cccaggttcc tcgtacgaaa gtgaagcccg
     2581 ctcccatggc cgacatgcct gacacgcctg acacgcgaga cgtcgttgca ctcattctcg
     2641 aggatcaccg aaggatggag gatctcttcc ggctgatgcg cagcgtggaa gccgaccggg
     2701 cagccgccct gcgggagttc gccgatctgc tgatcgcgca cgcgctggcg gaagaagcga
     2761 aggtgtaccc cgccctcaag cgtttcaaga agatcgagga cgaagaggtc gagcacggcg
     2821 aggaggagca cgaagagggc aacaaggcgc tcctcgagct cctggaggtc gacgaggtcg
     2881 gctcggacga gtgggacgag aagctggaag agctcgtcga ggcgatcgcc caccacaccg
     2941 acgaggagga gcgcacgatc ctcaacggcg cccgtgagaa cgtcgccatg gagcgacggg
     3001 aggagctggg cgaggcgttc ctggaggaga gggggcgtca gctgaaggcc ggctgcggcg
     3061 ctgtggagaa tgtgcgccgt atcgtcggct cctgatcgcg gctcctgacc gctgctcctt
     3121 accgctcctc ctcgcgcgac ctcggatcgc gactcgtcgc atgacctctg atcgcggccg
     3181 gcaagccctc gcgggagcca ctgacgcttc ggctcgccgg ccgcgaacca tcgcgccgcg
     3241 cgacggacgc ccgcggatcc ctggcgcctg cggatcccgg atgccgcgta tcggggatgc
     3301 ccgcggaccg gtggcgcccg gcggagagcg cgccggagcc gggggatctc gggccgcagc
     3361 cgggggattt cgggccggtc gctgccgggc tgggcggaga ctcggcgcgc ggccgctcgc
     3421 cggccggtgc cttcgccgtc cgccgacggc gccgggctgc cggcaggcct cggccgtgcg
     3481 gagcccccgg cacggagttc gcctcattcc gggccgtcgg cacgcgtgcg cagggcctgg
     3541 tacacggacc acaccacggc caccagcggt acggcgacca cggcgccgat cacccccgcc
     3601 gcgaccgctc cgccgacgac cgccagcgcg accaccaccg ggtgcaaccg gacggcccag
     3661 ctcatcacga gggggtgcag gaggtggccc tcgatctggc cgatgaccac gatcagggcc
     3721 acgaccacca gggcgatgac cgctcccttc gacgcgagtg cgacaacggc cgcgatcgcc
     3781 agggcgatcg gcgagccgat cagcgggatg aacgcggcca ggaactccag cagcgccaac
     3841 ggcaccgcca ggggcacccc cagggcgaac agcgcgatac ccacgagcac cgcgttggtc
     3901 gcggccacca gcaggatgcc gtgcgtgtag ccggtgaagg tccgccaggc ggcccgcccc
     3961 gcgaccgtga cctgccgccg tgccccttcg tggagctggt cgcacaccca ctgccattgc
     4021 cggtcgccgg agtaggtgaa gaagaccgcg cagaacacgg ccagggcgag cacggtcagc
     4081 acctcgatca ggcggctcgc gccgctgagc gccgtgctga tgagggtgga acggtggctc
     4141 gacagcagct tgccgatccg ggactggaga tcgtcgaacg cgtccggggg aagccggaag
     4201 ggaggctcct ccagctggcg ttcgatgcgg tcgatccccg tgacgaactc cttctccagc
     4261 ccactgcgct ggtccgccgc ggtctcaccc accagggcca gcgcgccgag aacgaggacg
     4321 atgccgccga tgagtgccac ggcgaccgcg agcggccggg gcatgaagcg ggcgaggagc
     4381 ccggccacgg ggcggagtac ggcggtgatg accagcccca ggaagacggc gacggcgatc
     4441 cggtggaact gcccgagcac ggagaaggtg acgtggacga cgacgccgac ggcgatgatc
     4501 cgccacgcgt acgcggccgc ggtccgcagc agacccggta cgtgcggctc cccgctgccc
     4561 ggacgttcga gcggcaaggc gggctgatcg gggggtgtgg gcatctcatg cccgtaccac
     4621 tcgccgaccg tccgggagcg gcggagcccc gaagttcccc cgaaggccgg taggaccgcc
     4681 gcacctcacc gcggccggat cacggcgtct tgccgaactg ccccctgggc gaggtcctct
     4741 gccgcgccga ccgcgccgac cgcgccgacc gcgccgaccg cggccaccgt gccgaccgcg
     4801 gccaccgtgg cgtcagaacc cttcacgcat cacgcccggc gcccggtcgg cgagggggga
     4861 gggtgcgctg cgtgtcgttc ggccggcagg cgcatcaacg ccgacggctc ccacccctga
     4921 ggacagggta ggagccgttc ggatgccttg ccgtctacga cgtcggcggt tcacgcgtgg
     4981 cggtgcgaac gccggttgcc cgtgacgagg cggtagaggg cgagcaggat gaaggagcct
     5041 acgatcgcgg cgatccaggt ggagaggtcg aagaacccgt cgatggagtc gactccgaag
     5101 atcaccttgc cgagccagcc gccgagcaga ccgccggcga tgccgatgag catggtgatg
     5161 atgatgccgc cggggtcctt gcccggcatc aaggccttgg cgatggcgcc ggcgagcaga
     5221 ccgatcacga tccacgcgat gatgcccatg gtgtctctcc gcttcgtcgt gtaaagacag
     5281 tgtcagtttc tcgtgtgcac catttgcctt cgaacaaacg tctatggcga atacttggtg
     5341 ggacgaggag agacgacccg gcttcgacga cggggagggc ggggcgggag gcgccggcgc
     5401 gacgcgggtg cctgtggtgg cgacacgctc cgcgcggccg cctcccccgg tccggccgcc
     5461 ggactctcaa ggctccgacg gccggtggac tgtcggagcc gcgaagaccg gcggccggtc
     5521 acggcttcga cggccggcgg accgtcaggg ccccgacagc cggcgcccgg tgtcccgggt
     5581 gagcggtccg aggtcctcgg ctctacagcg agggtgccga gcccggcagc gggcgccccg
     5641 ccgactcggc catgaaccac accgccacac caccgatgac ggccgcggcc atcatgtagt
     5701 aggcgggcat catcatgttc ccggtcgccc cgatcagggc ggtcaccacc agcggggtgg
     5761 tgccgccgaa gagcgacacg gagacgttga agccgatcga cagcgatccg taacggacct
     5821 tcgtcgggaa cagcgccggc agggcggccg gcatcgccgc ggtgaagcag accagcagca
     5881 ggcccagcgc gcccatgccg agcgcgaccg cgaacaggct gccctggcgg atcagcagca
     5941 gggcggggac ggacagcagc aggaatcccg cacagcccgc ggcgatcacc ggtcggcggc
     6001 ccacacggtc cgtcagggct cccgcgaagg gctggacgat catcatcacg gccatcacgc
     6061 cgagtacgac gagcaggccg tgcgtctcgt cgtagtggag ctcaccggtc agatagctcg
     6121 gcatgtacga cagcagcatg tagtcggtga cgttgaagac cagcaccagg ccgacacaga
     6181 gcagcagcgc ccgccactgg cccacgacca tccggcgcag cggcaccttc gggcggttcg
     6241 actcggcctt ctcgatctcg gccgcgaacg ccggggtctc ctccagccgc atccgcaggt
     6301 acaggccgac gatgcccatc gggcccgcga tcaggaacgg gatgcgccag ccccagctca
     6361 gcaggtcctc cgtggacagc agggcggtca tcaccgtgac cagaccggcg ccgccgatgt
     6421 acccggcgag cgtgccgaac tccagccagc tgccgaggaa gccgcgccgc ttgtcgggtg
     6481 cgtactcggc gatgaaggtg gaggcgcccg cgtactcgcc gccggtggag aagccctgca
     6541 ccaggcgggc tgccagcagg agcaccgggg ctccgacgcc gatcgacgcg tatgacggga
     6601 tgaggccgat ggcgaaggtg cccgcggcca tcaggatcat ggtgagggcc agcaccttct
     6661 gacggccgac gcggtcgccg agcggcccga agaccatgcc gccgatcggt cggaccagga
     6721 aggcggcggc gaaggcgccg aaggtggaga gcagctgggt ggtcgggttc ccggacggga
     6781 agaagacctt gcccagggtg accgcgatgt agctgtagac gccgaagtcg aaccattcca
     6841 tcgcgttgcc cagcgcggcg gcccgcaccg cgcgtttcac cagtgcgggg tccgtggtgg
     6901 tggcgttctc ggggacggtg gcgttcttcg ggacggtcgg gagggacggc ggtggagagg
     6961 cgactgtggc actcggcaaa gcttcgctcg cctactttcg tcgggggcag ggacgggtct
     7021 gctcgacggc gccggcggca ggccaaagag cgacgatagg cggacatgtc cccctcacgg
     7081 gctgtgcgca cttcgctgca tgctgcacgt aaatgtgctg tgggcaggcc cgtagcgccg
     7141 ctccggaggg cacttcacgg gatcatggtg tgacccatct cgcgtcccgc gcacgcaacc
     7201 gaaccgcctc accgggccga gggaacccgg gaccgcggcc cggtcaccta cgcggacgct
     7261 gacgcgggct cgggcccgta cgcggatgcg ggctcgggca agggctcggg cacggacacc
     7321 gaaggcggca cacggacacc gaaggcggcc tgttccgtac cctggcggca tgcgcatgcg
     7381 ccccactctg agctggaccc ccgcggagga cctgccgccg gggacgaccg atccggagcg
     7441 ggtcgtcgac gcgctgggcg ccggtggtgt gctggtgctc agcggggccg gcatctccac
     7501 ggagtcgggc atccccgact accggggcga gggcgggagc ctgagccggc acaccccgat
     7561 gacctaccag gacttcacct ccgatgcccg ggcccggcgg cggtactggg cgcgcagcca
     7621 cctcggatgg cgcaccttcg ggcgtgcccg gcccaatgcc ggtcaccggg cggtggccgc
     7681 gttcgcgcgg cacggactgc tctcgggcct gatcacccag aacgtcgacg gcttgcacca
     7741 ggccgcgggc agcgaggacg tcgtggaact ccacgggagc ctgggccggg tcgtctgcct
     7801 ctcctgcggt gccttcagtc cgcgtcacga gctcgcccgg cggctggcgg aggccaacgc
     7861 ggacttcgaa cccgtggcgg cggcgatcaa cccggacggg gacgccgacc tcaccgacga
     7921 acaggtgggg gactttcggg tgctgccctg cacggtctgc ggcggcatcc tcaaaccgga
     7981 cgtcgtgttc ttcggcgaga ccgttccgcc gccgcgcgtg gagcactgcc gcgcgctggt
     8041 ccgcgaggcg gcttcgctgc tggtcctggg ctcctcgctg acggtgatgt ccggacttcg
     8101 gttcgtccgc caggcgggcc aggccgggaa acccgtgctg atcgtcaacc gggacccgac
     8161 ccggggcgac cagcacgccg tcacccgggt cgcgctcccc ttggggccga cgctcaccac
     8221 cgtggccgcc cggctgggca tcccgctcga cgaacagggg gcgcccgcgt aggaccgtga
     8281 cggcgagcgt ggcgggtccg ctcttcggtc cttccgcggg tgctacctgc cgaggtcgcg
     8341 cagcacttct ctggcggcgc gcgcacccga ggccatcgcc ccttggaccg agcccgtggc
     8401 ccggtggtca ccgcacacgt atctgcctcg ggctacccgg gtcgtgcggc tgagttcctg
     8461 agggggcgcc atcgcgggca acgcgtcggg gaccgtacgg acggtcagca ggtcccagcg
     8521 gtcggcatcg gtgtcgtata cctcgctcag cgccgcgcgc agcgcgcgtt cccggccttc
     8581 ggtgtccgcg ccgagcaccg aggtggccac gagtgcccgg ccgtcgggcg cgtacgaggc
     8641 cgccacattg ctcagcacac acgtgttgag gaagcggcgc cgggtgtcca ccagcagagt
     8701 gggctcgtcc agcggcgggc ccggcatggc gtggtaatag gtcgtcaccg cgcggtacgc
     8761 gggcacggtg acaccgggca ggagggtccc ggccggtccc ggtccggtgg ccaccaccac
     8821 ggcgcgcgcc gggacgagtt cgcgggcggt ggtctccact ccgtcgtccg tcagacgccc
     8881 gaccggtgtc tcccgtcgca cggtgccctt cggcagcgac gccgccaggg cgagaggcac
     8941 cgcaccgata cccgcggcgg gcaggctctg ggtgccgcgc agcatgctgc gccacacgag
     9001 atggaagacc cgggcggacg tctccagccg gtcttcgagg aacaccccgg acaggaaggg
     9061 caggaagaag cgctcgacga acgcgtcggt gaagcccgcg tcggcaaggg cctggcgcgt
     9121 gctgcgatct ggccgccgct tcaggcggtg cggcggggcc accgcgtccg aggccgcgag
     9181 ggcgcccagc gccgccagat cgcgcggtcc cgcgagcctt cccgacagga ggtcgacgag
     9241 cgtggacggg tgggcgcggg ggtcggtcag gcggcgcctg cccttgtcgg tgtggatgag
     9301 gacgccccgg tcgaagggac gtaggtccag cccgtcaccg gtcaggcgtc gccggacctg
     9361 cgggtaggac gggttgaaga cctggaagcc gcggtcgatc acgaagccgt ccacccggtc
     9421 ggagcgcatc cggccaccga cctcgtcgga ggcttccagg atgcgcacgc cgacgccggc
     9481 ggccagcagg tcctgagcac aggcgaggcc ggcgacgcct gctccgatca ccacgacgtc
     9541 cgatgatcgt tcggttgcgg tcacgttgac ttccctccat cacctttcac cgggtcgccc
     9601 accgaaacaa ggggccagtg ccgccatgcg gctgcgcacc gtctcctcca cttcgttccc
     9661 gaccgggaga acggatgcgg gtcgggccgg attccgggct tcgtgtaccg gtcaatggtg
     9721 gcggcatgtg tgttcggttc ggccgagatc cgccaggggc aggccgaacg catatgcgcg
     9781 gtgcaatgga catgcagaac gacgagatgc ccgggcttcg cgcgccccga tgtgcgcgtt
     9841 gaatgcgctc tgtcaaccga agaccggcgt gccctacctt cacatcgcag gacgaaaaac
     9901 gttcaaccta tcactccgta agggagttga cggggaacag cgtgcgtact gcatccgtcc
     9961 gggaatggct tgtcgctgtg atggggggag cgttatggat atgcgctacg aggcgttttc
    10021 gtacgccgac aaagtgttct acgattcgcc ggtccgatgg gcggccgtgg aggagttcgc
    10081 ggccgtcggt gaacccttac ccgacggctg gctggcctcc gcgagagagg tgtgggtggg
    10141 ccgccggccc gccgacgtcg aactgcccga ccagggctgg aagattcacg tctccgcgtg
    10201 tctggacaac gcggagcaca ttctctccgt cgtcggctcg tactgcttcg aacagcgcgt
    10261 ggcccacaag ttcctgcgca gcccggccct cgtgcagacc cagaacgcga agtacgcctc
    10321 gcgcgggtcc agcggcaagt tcatgaccct gtacccggtc gacgaacccg agctcgagcg
    10381 gtgtctcacc gacctggacg aagctctcgc cggcctgcgc ggaccgtaca tactcagcga
    10441 cctgcgctgg cgcaacgggc cgctctacct gcgctacggc ggcttcacgg agcagttctg
    10501 ccgatccgag accggtgaac tggtcctggc cctgcgcgaa ccctcgggcc gactccgccc
    10561 ggacgtgaga cgcgccgtgt tcgaggtgcc cgagtgggct cccgtgcccg ccgtcctggc
    10621 ccaggccctg accgaccggg ccgcgacgag cacggccgac ttcccgtaca cggtcgaacg
    10681 ggccctgcac ttctccaacg gcggaggcat ctacatcgcg cgccccgcca ccggcggcga
    10741 tcaggtggtc ctcaaggagg cccgaccgga cgccggcctc gaccagcgcg gcgacgacgc
    10801 cgtactgcgg ctcggcagag agcacgacat cctgcggcgc ctggaaggcg tacccgtcgt
    10861 gccggccgcg ctgggccgcc tcacggcctg ggaacaccac ttcctggtgc aggagtacgt
    10921 gcccggcgag cccctgaaca gatggttcgg gcggcgctac cccctggtcc atcccgatcc
    10981 cgaccgggag acgatcgacc gctaccggga ggaggcgctg accgtcctcg ccggcgtcga
    11041 ggaggggctg cgcgccatcc acgcgcgcgg tgtcgtcttc ggagacctcc acccgcgcaa
    11101 cctgatcgtc cgcccggacg gacgggtgtg cttcgtggac ttcgaactcg cctcgcccgc
    11161 cgacgcgttc gtcagacccg cgctcggcgc cgccggcttc gccgcccctc ccgacctcga
    11221 gggctacgcg atcgacacgt acgcgctcga cgccctccgg ttgtggatct tcatgccgct
    11281 gctgcagctg acctcgctgg acccggggaa acgggacgaa ctgacggacg ccgccgcgag
    11341 acgcttcgga ctgcccgccc gaccggccga cggccggccg cccgcaccgc cccaggcccc
    11401 gcctcccgcg ctctcgcaag ccccgcctcc cgccccgccc tccgtaccac ccgccgatcc
    11461 ccgcgaacgc gccgcaccgg caaccctgtt cagcggcgac cgcgccgact ggcccgcgct
    11521 gcgggactcg ctggtcgcgg cgatcaacgc cagcgccacc cccgagcgca ccgatcgcct
    11581 cttccccgga gaccccagcc agttcaccca cgacggactc ggcctcgcct acggcgcggc
    11641 gggcgtgctc tgggccctgc acaccgtggg tgcgcccgtc gaccccgacc acgtcgaatg
    11701 gctcggggag gccgtcgcac gcgaaccctg ccgtcccggc ctctacaccg gcgcgcacgg
    11761 agtggccttc gccctggacc ggctcggtca cacgcggcag gcgcacaacc tcctcgaccg
    11821 gctcctcaag gacccgctcg acgcccaggg gagcgatctg gccggtggtc tgcccggcat
    11881 cgggctgact ctgctgcact tcgccggcac caccgccgac gcctccctgc acgccgtcgc
    11941 ggtcgatgtc gccgaacgtc tcgccgcccg cctgaaaccg gactccggca aggcaggccc
    12001 ggcacccgcc cgccgcccgg ggctgctgca cggcgcatcc ggcgcggccc tgttcttcct
    12061 gagcctccac gacagcaccg gtgacgccgg gctgctggac ctcgcggaac acgccctcga
    12121 cctcgacctg gcccgatgcg tcctgggcga cgacgggacc ctccaggtcg acgacggcag
    12181 ccgggtcctg ccgtacctcg aatcgggcag cgccggcatc gccgcgcccc tgcacgccct
    12241 gctgcgccac cgcccagacc cgcagcgccg acgcagcctc gaacagatcc gcggcgccgc
    12301 cgagcccgag ttcatcgtcc agtccggcct gttcaacggg cgggcggggc tgatcctgct
    12361 gctgcgcctg ctccaggacg acaccacact ccacgaccag gtcatccgac gccacatccg
    12421 gcgcctggtc tggcatctcg tcccctacca ggggcacgcg gccttccccg gcgagcagtt
    12481 gctgcgcctg tcgatggacc tcgccaccgg ctcggccggc gtcctgctcg cgctcggctc
    12541 ggccctcgcc gacaccccgg cgctgccctt ctggaacggc cgaggggccg cggctcccgc
    12601 gtccctcgcc ctccccaagg cgtcctgacc gccctccgac ggcagcggcg ccccctgcga
    12661 cacacggtcg cagcccagag tttccggcga tcgccggaaa gccccaaccg aagtgacagg
    12721 agtacaccat gtccatcctc agcctgcagg ccctggagac ccccgaggag accaccgagt
    12781 acctgtcggt gctcagctcc ctcagcgccg tcaactgcac caacagcacc gtcagcacgc
    12841 tgctgtgcct gtagtcgcac cgcccgggcc gtccgaccgc cccaccctcg gatgacctgg
    12901 tgaacagagc cggcccgggc tgagggacag cccgggccgg cgttctcgtg ccgccccgca
    12961 gaccgcccgt ccatctcccg caggagcccc cgtatgagac aggaccaccg acagcagcca
    13021 cagcggagcg gggctcccga tcgtacggct tcgcccaccc tcgcacagga tgcccgaccg
    13081 ccccggaacg gcctgccgag cgcccccgcc cgatggtgct ggcccaccgt cctcgccctc
    13141 tcggtggcga cgagttcggt cgccgcgctg gtgctgcccg ccgccctcgc cgcggccgtc
    13201 gaccgtgccc tgtccggcga cgccggggcg ggcgtcgcgc cgctcgccgc ggtcctctgc
    13261 ctgctcacgg cggccgagac cctcgcgcag tacgccggcc cgcgcgccac cgccgaggcg
    13321 acggcacggc tgcgcgccgc cctgatacgg cacatcatgg ccgtcggccc gtaccccgcc
    13381 cggcggacgg ccaccggaga cctggtcgcc cggatcaccg cgagcgccgc cgaggccgga
    13441 ctgagtgtcc aggcggccgt gtacgccgtc gcccaactcg ccatggcggc cggctccgtg
    13501 ctcgccctcg ggctgctcgc cccggaactg gccgccgcct tcgggatcac ggcgcccgtg
    13561 ggctggctgc tgctgcgccg ccatctgcgg cggaccgtgc gacggggaga gggctatcag
    13621 gccgcacagg ccgccgtggc cgcccggctg ctggacgccc tggccggcca ccgcaccatc
    13681 gcggccgccg gaacggtcga gcgcgagatc gagcgcgtcc tggcaccggt acccgaactc
    13741 tcccggcacg gccgcgccct gtgggacagc cagcgccggg tcgcctggtc caccggactg
    13801 ctcgcccccg cgacccagat caccgtgatc gccgtcgccg ggtacgaact gtccaccggg
    13861 gcactgggcg cgggcggcct cgtcgccgcg ctcggctacg ccacgctggg actcggcggg
    13921 ttcggcaccg cgcagagcct gctggaccac gcccgggccc gagccggacg ccggcgggtc
    13981 cacgaggtcc tcgcgccgcc ccggcagccc cctgggctgc gcggcctgcc gccgggaccc
    14041 ggacacgtcg agctgcacgc ggtcaccgta cgcagggcgg gctgcaccgt cctcgacgcg
    14101 ctggacctca cgctccccgc cgggcgctgc gtcgccctcg tgggccgctc cggcgcgggc
    14161 acctccctgc tggccgcggt ggccggggga ctcctggccc cggagcgcgg caccgtgctg
    14221 ctcgacggcg tacccatgga cgagatccgc cccgccgacc tgcgcgccgc cgtcgcctac
    14281 gccttcagcg acccgcggct gaccggcgcc acggtcctcg acgcgctgcg cgtcgcggct
    14341 gaacccctcc ccgaagcccg ggtccgcgcg gccgcgcgag ccgcccaggc cgacgtcttc
    14401 atccggcgtc tgcccgccgg ctatctgacc cccgtccgtg acgcgcccct ctccggaggg
    14461 cagcgccagc gcctgggact cgcgcgcgcc ctggcccgcg acggccggct gctcgtcctc
    14521 gacgacgcga cgtccagcct ggactccgcc accgaggccg cggtcctgcg tgccatcgac
    14581 gacacccacg cccaccgcac ccggctggtc gtgacgcgcc ggacggccac ggccgcccga
    14641 gcggacctcg tggtctggct gcacgagggc cgcgtccggg ccctcgcccc gcaccacgag
    14701 ctgtggcgcc tgcccgccta ccgcggcatg ttccgcggtg ccggggacgc gcagggctga
    14761 acaggaaagg acgacacccg tgggacaccc catggcggaa cacaccgccc gcccgccccg
    14821 cccgacgccg cgtccggccg cccgctccct caccgcggcc aacggcacag ccctgcgcct
    14881 gatccgcggc ggcctcgcgg acaaccgcgc cgccgccctc cggctgacgt ggtggacact
    14941 gctctccgcc gcgcccgccc tcgtctgcgg caaggccctc gccctcgccg tcgaccgggg
    15001 cttcctgctg gaccggcccc gcacggcggc cctcggactg ggcctgttcg ccctgtgcac
    15061 gctcggcggt gcctgggcga gccggcagac ctacccctgg ctcgccgaga tcgtcgagcc
    15121 gctgcgggac cgcctgctcc gcgacgtcgt cacgggcacc ctgcaccgcg cggtgacgcc
    15181 gggcgcggcg cgggacgact gcgccgcggt cgccgtcgcc cggctcaccc ggcaggtcga
    15241 gaccgtacgg gacgcgctcg ccggccagct catgctcctg tggcagttcg tcctgacggt
    15301 cgccgccgtc gtcaccggca ccgccgtcct cgccccggcc gccgtccccc tggtcgccgg
    15361 cccgctcctc gtggccctcg cactcttcgc cgtcctggcg cccgcgaccg tccgcagaca
    15421 acgagcggcg ttcgacgccg aggaggccct ggcgggccgc gcggtcgaga ccgtcgaggc
    15481 gctgcgggac atcgtcgcct gcggagccca cgagcacgcg caacgcgagg ccctcgacgc
    15541 ggtgcgccgg cacctgcgcg catcgagggc gctcgcctcc gtgtccgcgc tgcgccgcct
    15601 gatcgtggcg ctgggcgcgc acagccctct cctgctcgtc gtcctcgccg cgccggtcct
    15661 gctcgcccac ggcatgaccg ccggcgagat cgtgggcgtg ctcgcctacg tcctggccac
    15721 gctggaaccg gcgatccggc tgctggtcca gggcctcggc gcctcctggc tgcgcctggc
    15781 cgtggcggcc gagcgtctcg ccgacgccgc gcgccgcccg gagccccgcc cggacccccg
    15841 acccgccctg cggcccgcgg acggctcggc caccctgtcg ggggtcgcct tcgcctacgg
    15901 cccggaggcc gaacccgtgc tcgacgggct cgacctgtcc ctcgccgacg gcgaccacct
    15961 cgtcgtcgtc ggcccttccg gcatcgggaa gtccacgctg gcggacctgc tgaccggcat
    16021 gctgacgccg caccgcggcc ggatcctcct cggcggtgtg cccctggacc ggatcgcccg
    16081 gcaggacctg gcacacgccc gggtcctgct gccgcagacc ccctacgtct tcgcgggcac
    16141 cctgcgcgag aacctctgcc acctcgctcc cggcaccccc gacggtgtcc tcgccgaggc
    16201 ggtggcggaa ctggggatga gcgctctggt ggagcggctg ggcggacccg ggggccgggt
    16261 cgatccggcc ggactctcct ccggcgaacg cgaactcgtg gccctggccc gcgcctacgt
    16321 ctccaccgcc cgactggtcg tcctcgacga ggccaccggt cacctcgacg cggcggccga
    16381 gcggcaggtg gaggaggcgt tccgccgacg gcccggaacc gtcgtcacca tcgcgcaccg
    16441 cataagctcg gcccgcagcg cggaccaggt gctgctcctg gacggaggcc gaccgcgcgt
    16501 cggcacgcac cggaccctgc tggcccaagt cccgctctac gccgacctga tgggccactg
    16561 gcgaacgggc gcgaccgaag acggtcggcc cggggacgcc cacccggggg atgcccacgt
    16621 ccgtgacagc cgtgccaggg aggctcacgc cagggactgc cacgccgggg atgcccacgt
    16681 ccgtgacagc catgccaggg aagctctcgt cggagacggc caccccggag acggacacgc
    16741 cagggacgcc catctcatga acgcccacgc caaggacggc cacccccggg acgcccaccc
    16801 gggggatgcc cacgtccgtg acagccgcgc cgggaacgct cacgccgggg acggccgccc
    16861 cggggacagc cccgcccggg gcgaccgcgc ggtggcccgg ctcaacagcc cggacgcagc
    16921 atcagatcgc tcatcgtcgc gtcccgtggc agatccagcg ccgtgacgac ggcggccgcc
    16981 acggacgtcg ggctcatatg ggcctccggc acgtagggca gaccgaactg cccgtgcaac
    17041 cggacctgca tcggcgtgtc cgtctctccg gggtacaccg tggtgacccg cacgccgtgc
    17101 gcgaactcct ccgcccgcag ggactcggcc agcgccttca gcccgaactt ggacgcggcg
    17161 taggcgctga gccgcggcgg cgcgtgcaca ccggcgcccg agttcacgaa gaccacgtgt
    17221 ccccggctct cacgcagcgc gggcagcagc aagcccgtca gctccgccgg ggcgatcaga
    17281 ttcacggcga gcgtgtcctg ccagacctcc gcgctcaact cgcccacccg gcccgactcc
    17341 gccaccccgg ccacgtgcag cagcgagtcc agccgcccgg gcagcgcctg cgcctccagt
    17401 cgggctcgta tggctcccgg tacggacagg tcggccacca gggtccggct gcgggggaac
    17461 cgggcccgca gctctccggc ccgcgcctcg tcccgtgcca gcagccacaa ctcctgtccc
    17521 cgcgaggcga acagcgccgc caacgccgcg ccgatacccg aacccgcacc ggtgatgagg
    17581 tgaactccca taccctgatt catacccaat atcaccacct caccccttac gtggcggacg
    17641 agttggggac gccaggccgt ccgcgcgtcc ggccgcaggt caggtcagcc accggccgtc
    17701 gcgcatcagc tcgcggtccg acagctcgtt ctcctcgcgc caggcctgga tgcggcgcgg
    17761 gacgatccgg aaccagcggt acgacgtggc cgacgcgcgc ggatcgaagc ccgtgcgttc
    17821 ggcgaaccgg tcgcctcgct cccgcggcag cgcgtcgagt tcgaggacgt cgacctcgcc
    17881 gtcgatcatg gtgacgtcgc gggtgcggcc gagcgccagc cgcaccacac gggacgcggc
    17941 caggttcctg ccggtggggc tgttcgtcgg ggtggcggcc aacagggcct ccccgtccca
    18001 gtcgaaggac agcggcacca ggtacggcgc gccgtccgcc gaggcgctgg ccacccagac
    18061 gtcgacgtcg tgggtgagcc ggtgttcggt gtcgtgacga cgctgagcgt gggagcgggg
    18121 ttcggtgtgc atcggtcctc cgggagtccg tcgtggtcac gatcggcaga agtccggtcg
    18181 tgggtcacga tcgccccggg aatcccgccg ggccggtcgc ggtggtcaca gactctcccg
    18241 gcacgggtgc gggtcgcctc cgtgcccacc acggaatccg ccacggacga acggatatcg
    18301 agacggataa tgaggcggtg atcggttcag agatatccgc ccgggaagcc caggtgctcg
    18361 cactgctcgg ggagcacctc agcaacgcgg agatcgccgc gcggctggtc atctccgtac
    18421 gcaccgtcga gtcgcacgtc tcctcgctgc tgcgcaagct ccaactgccc gaccggcggg
    18481 cgctcgcccg gcacgcggcc gagttcgccc gcaccgaacc ctcggtcgcg gcacccgccc
    18541 tgccggcccc gctgacggcg ttcgtcggcc gggtggcgga gcgcgggcag ttggccgagg
    18601 cggtgaaagc gcaccagttg gtgacggtgg tcggccccgg tggggtgggc aagacgcgcc
    18661 tcgtgctggc ggtggcggcg gagatggcgg acgacttcgc cgacggggtg tggttcgtcg
    18721 acctcgtccc ggtcaccgaa ccgggtcggg tgggcgcggc cgtcgcggcg gccgtggggg
    18781 tgggcgagca accggggcgc ggcatcgacg aggcggtgct cgccgcgctg acggaccgcc
    18841 gggcgctgct ggtgctggac aactgcgagc gggtgagcga cgcggtggcg ccgttcctgg
    18901 agcggctgtt ggcggtctgt ccgcggttgc gggtgctcgt gaccagccgg gccaggctga
    18961 tggtgccgtt cgagcgggtc ttccaggtac cgccgctgtc gcgggcgggc ggtgaccggt
    19021 cggaggcggt ggcgctgttc atggaccgcg cgtcggcggt cggccagccg cccggaccgg
    19081 cgtcgaacga ggaggtcgtg accatctgcg aacggctcgg cggcatggcg ctggcgatcg
    19141 agctggcggc ggcacgctgg tccaccctcg gactggacgg cctcacggca ggcctctccg
    19201 atccgctgcg gatcctcacc ggcgggcccc gcgccgacga ccggcaccgg tcggtgcggg
    19261 cggtgctgga ctggagccat gacctgctgg agccgcagag ccgggccctg ctgcgccggg
    19321 tgtcggtgtt cgtggcgccg ttcaccgcgg aggcggccgc cgaggtcgcc gggttcgctc
    19381 cgctggatcc cgccgcggtc gtcgacgggc tcggcagact cgccgagcag agcctcctgg
    19441 ccgtgacgtc ctcggccacc ggcacccggt accacgcgct ggagaccatc cgccagtacg
    19501 ggacggaacg gctcaccggc gccgacgaac tcgtccaggt ccgatcccga cacctggact
    19561 ggtgctcgac cggcgcgcgt gccctcgtcg gagcgtcggg cgcggactgg cgcgcccggt
    19621 tcgaggccgt ggcggacgac ctccgggccg ccctcacctg ggcgtccgac cggccggatc
    19681 gccgcgcgga cgcgcgtcgc ctcgccctgt ccctggccga gctggccttc ttccgcaatc
    19741 tgctcggcga gtcccagcag cggtacgagc aggcggccgg gctctccgac gacgccgacg
    19801 gggccgcggc actgcggcag gccgccgcgg tcgccgggtg ccgaaggctc ggggacgaga
    19861 tgttccggct gcgccgggcc gcggcggacg ccgcgcgccg ggccggggac accgccggtg
    19921 cgggcggcga cctggcggcc gccgccaccg acgcgtaccg cttctccagc acgttcgcgc
    19981 aggtgccctc ccgggaagag gtgacggccc tgctcgcggc ggcgcaagag ctggccggtg
    20041 acgccccggc cgctcgggcg gctgtcgcgc tggccgaggc ggcggtcgtc gccgacgcgt
    20101 tcggcgccgt ccagggcgag ctggacaaca ccgtggagga gacggtcgta cgcgccgaac
    20161 gcgccgtcga cctcgcccgg tgcgcgggcg acccggtggc ggagtcggcc gccctcgacg
    20221 cgctctccgg ggcccgggcc tggaccggtg aggccttcgc cgccgcgtcc gccgcccggc
    20281 gccggatcga cgtcctggac tctgcgccgc gtaccccggc cggtgcgcac gagctcatgg
    20341 acgccctcgc catggccgcc ggaaccgccg tcggagtggg ccggctgccg gaagcccgcc
    20401 ggtggggcgg acagctcgcc gaccacccgc tgctcgccga ggtggggcac cacgccacgt
    20461 cctggctgct ggtcgcggac gccttcgccg gccgtgccga ccaggtgctc accggcagtg
    20521 cgcggttcct cgacgcgtgg gagcggagcg gccgtcagcg gtcgttctcg ctcggccccg
    20581 ccgccgccgc ggtcgccatg gtgcacggcc tgcgcggcga ccacgacggc cgggacacct
    20641 ggcgcgcgat cgtcgaccgg gcgggcaacg cacccgagca ccgccacggc tacggggcgg
    20701 tcttcgacgc catggtgctg ctccacgacg gggacgcgga tgcggcggcg cggcggctcg
    20761 cgccggagcc ggatcaggtg tggaagtggg tgtcctgggt ctggctccac tggtacgtgg
    20821 cgcttcgggc ggaggcagcg gtgctcaccg ggcacccgga cgcccgggcc cggatcgacg
    20881 ccgcccgcac ggtggtcgcc ggcaatccgg tcgccaccgc ccaggtggac cgcgcgcagg
    20941 ccctgctcga cggcgacccg gcacggcaac tcgccgccgc cgcggccttc gacgcggccg
    21001 actgccccta ccagtcggcg cgcacgctgc tgctcgccgg gggcgaacac gccgccgtgg
    21061 gcacctccgt gctggccggc ctcggtctcg cacccctggc cgtgcggtag cggcggcacc
    21121 atccgtgggc ggtacgtggg gggcgtggcc ggacggcgcg gcgtggccgg gcggagcgga
    21181 gccgaagccg ccccaccgcg ccgcccgttc accggccggt gcgccgtcag ctcacggcct
    21241 gcttcaccag tgcggcgatc cgcgcctcca cctcggccgt cacctccgtc aaggcgaagg
    21301 cggtcgccca catcgtgccc tcgtccagct tcgccgtgtc gttgaacccg agtgtcgcgt
    21361 agcgcgactt gaacttcgcc gcgctctgga agaagcagac gaccttgccg tccagcgcgt
    21421 acgcgggcat gccgtaccag agcttcggcg cgagagacgg ggcgttggcc gtgacgacgg
    21481 catggacgag ctcggccatc gtccggtcgg agtcctgcat ctcggcgatc ttcgtgagca
    21541 cgtcccgctc cgcctccgcc gccttgtccg cgcgggagcc gcggcgcgcc gccttcttct
    21601 gcccctcggc gtgctccttc atcgcggccc gctcctcggc cgtgaatccc tcgtacgtgc
    21661 tgccgtcggt gctgctcatg gttgctcccg tggtcaaggc gtggaccgtg atcggcccgg
    21721 cgggtcctgc cgggcccgtc gctgtgggtc acagcctccc ccggacggcg acggagcgcc
    21781 tccgtgctga ccacggaaac caccacggag aggtcggtac acggctgcgt acctctcccg
    21841 gcgaccaggt cttcgtcctc ccgtccgtgc cgtatcgcga ggagaacccg gacccggccg
    21901 aggaggccgt ggtggtcatc gcccgcagca cccgggaggc gatcgtcgtc gacctgccgc
    21961 acctgtacgt accggggcgc gagcgggact gaccggccgg tgacttccgc gcgcggaggc
    22021 ggctcagtac gggctggtct cgccctcggt cgtcacgccg aaggtgttga ggaagttgct
    22081 gacgagctgg tagaagccga ccgtgatgac gaggtcggag agctgaccca ccgtgaggaa
    22141 ctccagcacc tccgcgcgct cggcgtcgct cagggtgtgc cgggcgagca ggcggtccgt
    22201 gcagcgcagg accgacgcct ccgcgtccga cagcccctcc gtggaacccg tggccgcggc
    22261 ggcgagggcg gcccggctca gaccgaccag gcggccgatg ttctcgtggt ggtggacctc
    22321 gtacggcgcc cggtagacgc ggcccacccg cacgatggcg agctcgcgca acccgtccgg
    22381 gagcgcgttg cgctgcagga tcgcgtcggc cgtctccagg aggccggggg cgagccgtgg
    22441 cgagtgcatg atcatgcgga agacgttgag cgaaccgcgc gcggcgacgg cctcccgcag
    22501 ctccgccggc agggccgtca ggtcggggta ctccatgggg gactccttcg tcaggggcgg
    22561 cccggccgga cttccggacc gggtcgtgcc gtcccactgt gccgccgggc cccggagcgc
    22621 cgcgaggg
//
