LOCUS NZ_LMEQ01000023 51606 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_3, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000023 VERSION NZ_LMEQ01000023.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 701632) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 701632) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 573088 Orig. end :: 624694 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000023.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..51606 /candidate_cluster_numbers="1" /candidate_cluster_numbers="2" /candidate_cluster_numbers="3" /contig_edge="False" /product="hglE-KS" /product="T1PKS" /region_number="2" /rules="(hglE or hglD)" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /tool="antismash" cand_cluster 1..51606 /SMILES="CC(=O)C(OC)C(=O)C(=O)O" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(hglE or hglD)" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="neighbouring" /product="hglE-KS" /product="T1PKS" /protoclusters="1" /protoclusters="2" /tool="antismash" cand_cluster 1..47053 /SMILES="CC(=O)C(OC)C(=O)C(=O)O" /candidate_cluster_number="2" /contig_edge="False" /detection_rules="(hglE or hglD)" /kind="single" /product="hglE-KS" /protoclusters="1" /tool="antismash" protocluster 1..47053 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[20000:27053](+)" /cutoff="20000" /detection_rule="(hglE or hglD)" /neighbourhood="20000" /product="hglE-KS" /protocluster_number="1" /tool="antismash" proto_core 20001..27053 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(hglE or hglD)" /neighbourhood="20000" /product="hglE-KS" /protocluster_number="1" misc_feature 357..370 /note="TFBS match to CatR, H2O2-responsive repressor, confidence: weak, score: 17.99" /tool="antismash" misc_feature complement(660..674) /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 17.74" /tool="antismash" misc_feature complement(2343..2357) /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 18.07" /tool="antismash" misc_feature complement(2754..2769) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 21.58" /tool="antismash" gene 2881..3018 /locus_tag="ASD48_RS44415" CDS 2881..3018 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="ASD48_RS44415" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_157880701.1" /transl_table=11 /translation="MSTMRRLAVVTGLATLAILGVTAPNASAAEPASTAAVGTYRCIMM " gene 3101..3604 /locus_tag="ASD48_RS26615" /old_locus_tag="ASD48_17090" CDS 3101..3604 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019063550.1" /locus_tag="ASD48_RS26615" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17090" /product="hypothetical protein" /protein_id="WP_057604229.1" /transl_table=11 /translation="MEPISVALLAALAAGAGGEAGREAWATLSELVRRPFRRDGRHDGS GDGSGGDDGEGEGEGNTGAPAAGSAEPELVRLAADPDDAALARALSTALAVRAAGDADF RAGLARWHELAGPLRTGDVHNEISGGTFTGPVLQGRDFSGLSFTIPAPPSVDPGRNTPP TAPD" gene complement(3632..5227) /locus_tag="ASD48_RS26620" /old_locus_tag="ASD48_17095" CDS complement(3632..5227) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127442.1" /locus_tag="ASD48_RS26620" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17095" /product="GMC family oxidoreductase" /protein_id="WP_057604230.1" /transl_table=11 /translation="MTDAQYYDVIIIGTGAGGGTLAHRLAPTGKRILLLERGGYLPRER DNWDSTAVFVKGKYRAPEFWYDKDGKEFPPEVNYYVGGNTKFYGAALFRLRPEDFGELR HHDGVSPAWPLSYEEFEPYYTQAEHLYLVHGRHGEDPTEGPTSAQYAHPPVQHEPRIQQ LSHDLEKQGLHPFHLPIGVNLTQDERGRATHTSACIRCDRVDGFPCLVGAKSDAQVICV DPALEHPNVEMVTHADVRRLETDATGRSVTSVVARVGEPGDGDAATVEFRADLVVVACG AVNSAVLLLRSANDRHPRGLANSSDVVGRNYMRHNNLALMAVSREPNDTRFQKTLALHD WYLGADDWDYPLGGIQMLGKSDSEQIHGEAPRWAGAMAPDMPFEVLAHHAVDFWLCGED LPAAGNRVTLDRDGGIHLALDEKNNVAGLNRLRHKLQGMLGHLGMNEHHLLSHSIYLHK GMPIGATAHQAGTVRFGDDPGGSALDVHCKAHDLDNLYVVDTSFFPSIGAVNPSLTAIA NALRVGDHLAERLA" gene complement(5393..6325) /locus_tag="ASD48_RS26625" /old_locus_tag="ASD48_17100" CDS complement(5393..6325) /EC_number="3.5.-.-" /GO_function="GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127441.1" /locus_tag="ASD48_RS26625" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17100" /product="cyclase family protein" /protein_id="WP_199875962.1" /transl_table=11 /translation="MRTSGDLSEADFRRLYRQLRDTSPGGAGRRGALDTITADLVLAAV GEVRSGRTVSLAAPVNTRGGPDDADPAEHRLTAPPGGEPGTSGLEFARDRFAMNVHGDV NSHLDALCHVVYDGTLHGGVPAADVLSPHGASALSVDLARDGVVGRGVLLDIPRLHGVP WLEPGARVGAEDLAAAEARQGVRVGRGDILLVRVGHRRRREELGPWDVTGARAGLHPTA MEFLAEREVAVLGGDGNNDSAPSPARGVAFPVHVLGIHAMGLHLLDYLRFEDLAPICAS EGRWSFLLVVAPLRLPEATGSPVNPLAIL" misc_feature 6427..6441 /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: strong, score: 21.24" /tool="antismash" gene 6719..7153 /locus_tag="ASD48_RS26630" /old_locus_tag="ASD48_17105" CDS 6719..7153 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127440.1" /locus_tag="ASD48_RS26630" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17105" /product="DUF6325 family protein" /protein_id="WP_057604231.1" /transl_table=11 /translation="MGPIDYVVVEFPGSRMTGEGFPLLVDLVDRGLIRILDLLFVRKEE DGSVVGLEIADLTGDGVLDLAVFEGASSGLLGQDDIEEAGGALGAGNSAAILVYENLWA APFATALRRGGAQLVASGRIPVPAVLAALDETDDVRPPST" cand_cluster 7062..51606 /SMILES="CC(=O)C(OC)C(=O)C(=O)O" /candidate_cluster_number="3" /contig_edge="False" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="2" /tool="antismash" protocluster 7062..51606 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[27061:31606](+)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="2" /tool="antismash" proto_core 27062..31606 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="2" gene 7167..8915 /locus_tag="ASD48_RS26635" /old_locus_tag="ASD48_17110" CDS 7167..8915 /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0015297 - antiporter activity [Evidence IEA]" /GO_process="GO:0006812 - monoatomic cation transport [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /GO_process="GO:1902600 - proton transmembrane transport [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127439.1" /locus_tag="ASD48_RS26635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17110" /product="cation:proton antiporter" /protein_id="WP_057604232.1" /transl_table=11 /translation="MTEDEVFLGLGLIIVLAVGSQVLAYRLRIPALIVLLPVGFTAGAL TDDLDPERLLGSAFSPLVSLAVAVILYDAGLGLDLRGLRGHTRRVVVRLIWFGALVSGA SAALVAMPLLGMSQGAAVMLGAILVVSGPTVVGPLLTFVRPTERLRRILVWEGSLIDPV GGILGALVFHTVTAGGPGGFGSRVGAFAVSTAVGVAGGVVGAVVLTVALRRLRLGEVLA TTVQLAAVVGVAAACDVVRDDTGLIAAVLMGLAVANLPGGGVTARRPFFETLVNLVIGL LFISISATVSPQSLRHVVLPTLGPVAVLVFVARPLVAAVSAWGTDLTPGERGFLGWMAP RGIVAAATASTFSATLVDQGVRGAAKILPATFVVIVATVTLYGLSAAAVAGRLGVVRST RSRPLLVGGDPWVVDLGRALRSAGLEVVMWAGRETERDSIRAAGIELAPGELFAAATGE GAELEGLTGVLLLTGEDDFNALAATRLEGSVECTVHRLRPPADSQGVITPYAGGEVLFD PDLTGPELARRHARGARVVAHRCDGTLPAGHRMLFLVRGDGRLLPVTRADGPAPRPGDV AVLLSA" gene complement(8920..9498) /locus_tag="ASD48_RS26640" /old_locus_tag="ASD48_17115" CDS complement(8920..9498) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127438.1" /locus_tag="ASD48_RS26640" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17115" /product="gluconokinase" /protein_id="WP_057604233.1" /transl_table=11 /translation="MTGGGESVRGEPVRGAGQAPPIVLVLGVSGSGKTTVGKALAERLG VTFVEGDGFHSAANIAKMTAGHALDDADREPWLRALAARVRHSAEAGEGLVVACSALKR AYRDELRAAAGPRLWCLYLALDRDTARDRVSRRTGHFMPARLVDSQFATLEPLQADEPG LTLDATTALPAALARVRAAVASFGRSTGR" gene complement(9495..10544) /locus_tag="ASD48_RS26645" /old_locus_tag="ASD48_17120" CDS complement(9495..10544) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127437.1" /locus_tag="ASD48_RS26645" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17120" /product="cytochrome d ubiquinol oxidase subunit II" /protein_id="WP_057604234.1" /transl_table=11 /translation="MTEDVVAWVLLAVVAAYACAGGTDYGAGFWDLLAGGTARGKRPRW LIDHAMEPVWETNNVWLIFVLVIMWTGFPVLFQTVFTAMWLPLALAAVGLVLRGAGFAL RKPTQRLAGRRVYGAVFAVSSLLTPFFLGAAVGGLATGRVAPGTKASADAWSNGTSVIA GLLTVAATAFLGAVFLTADARRFDAADLVGYFRLRAWCSLGVLAVLACVGLVVTRDDAR YVHDGLTSGIGLALVLVAVVSALATAVLLYRTATGWARITAVGSVALVVVAWGLAQRPY LIPTSLTVSEAAGATTTLRWLLLVTAIAVVLVGPPLVLLYRLNTAGALQPLTEADLRRT AAGREPESP" gene complement(10541..11929) /locus_tag="ASD48_RS26650" /old_locus_tag="ASD48_17125" CDS complement(10541..11929) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_component="GO:0070069 - cytochrome complex [Evidence IEA]" /GO_function="GO:0009055 - electron transfer activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0019646 - aerobic electron transport chain [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127436.1" /locus_tag="ASD48_RS26650" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17125" /product="cytochrome ubiquinol oxidase subunit I" /protein_id="WP_242432741.1" /transl_table=11 /translation="MAFTLGSHILLVPFGVALPAITLLMHYRGLRKGDAVALLLARRWS AVMAVQFAIGIVTGTVLSFELGLLWPGMMGRWGDVFGLGFGVEAWAFFLEAILIAIYLY GWRRLKPWTHFWLGLPLPLAALMGAFGIVAANSWMNTPRGFSLDASGAPVDVDVRRAIF TPMFGPEYWHFVVGVVLTAGYVIAGVYAVGWLRGRRDRYHRLGFTVPFSVAAILTPVQF VLGDSIARSVFHKQPVKFAATEIVWKTDTHVPEYMFGRLHSDGTISGGIRIPQLDSILA GFSPDTKVTGLSSVPAADRPTATQATIAHWAFDIMVTIGSLLVLLALWYGWCWLRRRDL PRSPWFFRCAALAGGACLLTVECGWITTEVGRQPWIVYQNMRVAEAVTDTRASTLWTML GLVVVLYALVFGAFLTVLLRMSGRWRLADEGAAAAATPEDLEGDTPYGPRPVSATGGRD GGGA" gene complement(12041..12880) /locus_tag="ASD48_RS26655" /old_locus_tag="ASD48_17130" CDS complement(12041..12880) /NRPS_PKS="Domain: PKS_KR (22-192). E-value: 2.7e-12. Score: 38.9. Matches aSDomain: nrpspksdomains_ASD48_RS26655_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127435.1" /locus_tag="ASD48_RS26655" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17130" /product="SDR family oxidoreductase" /protein_id="WP_057604236.1" /sec_met_domain="adh_short (E-value: 4.8e-36, bitscore: 119.7, seeds: 230, tool: rule-based-clusters)" /transl_table=11 /translation="METSGNDGRQPLAPLLLKGQKALVTGANSGIGKATAIGLGRVGAD VVVNYVAGREAAEEVVREIEGFGVRAYAHEADVSQEDQVVDMVSRMVEEFGTIDVMVAN AGLQRDAPLTDMTIDQWRKVLDVNLTGQFLCAREAAKEFMRRGVVPEVSRSAGKIICMS SVHQIIPWAGHVNYASSKGGVQMLMATLAQELAPHRIRVNAVAPGAIRTPINRSAWETP EAEADLLRLIPYHRVGDPDDIANVVATLASDLLDYVVGTTIYVDGGMTLFPGFATGG" aSDomain complement(12305..12814) /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26655_PKS_KR.1" /evalue="2.70E-12" /label="ASD48_RS26655_PKS_KR.1" /locus_tag="ASD48_RS26655" /protein_end="192" /protein_start="22" /score="38.9" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C2" /tool="antismash" /translation="LVTGANSGIGKATAIGLGRVGADVVVNYVAGREAAEEVVREIEGF GVRAYAHEADVSQEDQVVDMVSRMVEEFGTIDVMVANAGLQRDAPLTDMTIDQWRKVLD VNLTGQFLCAREAAKEFMRRGVVPEVSRSAGKIICMSSVHQIIPWAGHVNYASSKGGVQ MLMATLA" misc_feature 13090..13105 /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 19.5" /tool="antismash" gene complement(13215..13646) /locus_tag="ASD48_RS26660" /old_locus_tag="ASD48_17135" CDS complement(13215..13646) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127434.1" /locus_tag="ASD48_RS26660" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17135" /product="hypothetical protein" /protein_id="WP_057604237.1" /transl_table=11 /translation="MTATGMHHRQGRASGGGAWVSGWTGFAGVMMIFGGVMAIFQGIAA IAQDDVFVVTRDYAYNFNLTSWGWIHLVLGVLVALAGAALFGGAVWARVVGVGLAGLSM IANFMWLPYQPVWAIVLIAVDAFVIWALCIGTGRDARTE" gene 13887..14174 /locus_tag="ASD48_RS26665" /old_locus_tag="ASD48_17140" CDS 13887..14174 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005483479.1" /locus_tag="ASD48_RS26665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17140" /product="SHOCT domain-containing protein" /protein_id="WP_057604238.1" /transl_table=11 /translation="MPGLLRGVARTAVVAGTATAVSNRVSRRQQGRWAQQDYQQAAPPQ PAPAPQPAAAPPPADMSSKIDQLKQLGELKAQGVLTEAEFEEQKRRILES" tRNA complement(14233..14306) /anticodon=(pos:complement(587358..587360),aa:Pro,seq:ggg) /inference="COORDINATES: profile:tRNAscan-SE:2.0.12" /locus_tag="ASD48_RS26670" /note="Derived by automated computational analysis using gene prediction method: tRNAscan-SE." /old_locus_tag="ASD48_17145" /product="tRNA-Pro" gene complement(14233..14306) /locus_tag="ASD48_RS26670" /old_locus_tag="ASD48_17145" gene complement(14351..15781) /locus_tag="ASD48_RS26675" /old_locus_tag="ASD48_17150" CDS complement(14351..15781) /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1005: Drug resistance transporter, EmrB/QacA" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127432.1" /locus_tag="ASD48_RS26675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17150" /product="MFS transporter" /protein_id="WP_057604239.1" /transl_table=11 /translation="MPRKSTRLTFAVLATGAGVFSMLQSLIAPALPTVQHALHTSQSTA TWVMTAYLLSASVFTPILGRVGDLIGKKRTLVGVLLAVLAGCLLAALAPNIGVLILARV VQGIGGALFPLSFGIIRDEFAPSRVPGSISNLSAVIAAGGGVGMVAAGPIVSALDYRWL FWIPVGIVAAATLIALRYVPESPDRAEGRVSWLGAVLLSGWLVALLLPLSQAGNWGWGS ARVIGLFALAVALFALWLYTEARSRSPLIDLRIMRLPAVWTTNLAALLFGAGMYAIWSF LPGFVQTPGTAGYGFGASVTASGLLMLPMLLAMFVSGVLGGRLEPRVGAKALLTAGAAL GALALGFLALWHDERWQVAFVAGVFGLGIGLAFASMANLIVGSVPAGQTGAATGMNANI RTIGGSIGAAVTSVLVTGRLQPSGLPYESGYTHGFTLLAVLCLGAALAALLVPVRRADR LPGPAARQTPTAAPTPVR" gene 15906..16487 /locus_tag="ASD48_RS26680" /old_locus_tag="ASD48_17155" CDS 15906..16487 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1057: TetR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014676283.1" /locus_tag="ASD48_RS26680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17155" /product="TetR/AcrR family transcriptional regulator" /protein_id="WP_057604240.1" /transl_table=11 /translation="MPAQPFPISEIVAAQRPVRKDAARNYDALLAAARQAFAEHGSEAS LEDIARRAGVGIGTLYRNFPTRRALFESVYADEVNALCRYAVEFADLEPWEALTAWLER FAGYMVTKRAVREALEGESEIFQACRDSMYAAGGPLFERAQRAGAARADMDFGDLLRMV AGITATAFVDDAQRDRVLAIALDGVRAGRR" gene complement(16495..17697) /locus_tag="ASD48_RS26685" /old_locus_tag="ASD48_17160" CDS complement(16495..17697) /EC_number="3.1.1.103" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1053: beta-lactamase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127430.1" /locus_tag="ASD48_RS26685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17160" /product="serine hydrolase domain-containing protein" /protein_id="WP_057604241.1" /transl_table=11 /translation="MTRTRTALLCAAALLASTFQTAAVAATAVPDHQGRPCTSTPKPRG QAREVLALVRAARKELGLKAALVKVTVGGRELVTGAVGESLTDVPATPAMHFRTGSVGI AFMGTVLLQLVEEHKARLDDPVSRWLPDLPHGDKITLRMLGDSTSGLHDYVTDPVFLKK LYADPWQHWTPEEVVGISLSHPLWYRPGTNWSYSHANFVLLGRALEKISGTPLDRLLRQ RVMKPLKLRNTRNNDTALIPPPVLHAYDDERGTYEESTYFNPSWTTAPGAVLTQDICDL ARSGQGIGSGELLSKRSFRTQLDPGTVGLGHPTANCPATVCLPMTEDFHFGIGVVVKNG WVVQNPSFFGYAAVMAYEPHQRLSIAVSTTVGPDAPEGNTAQTITERIADLLAPRYPLS G" gene 18669..19427 /locus_tag="ASD48_RS26690" /old_locus_tag="ASD48_17165" CDS 18669..19427 /NRPS_PKS="Domain: PKS_KR (8-115). E-value: 2.1e-08. Score: 26.2. Matches aSDomain: nrpspksdomains_ASD48_RS26690_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short_C2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010983052.1" /locus_tag="ASD48_RS26690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17165" /product="SDR family oxidoreductase" /protein_id="WP_057604242.1" /sec_met_domain="adh_short_C2 (E-value: 3.7e-36, bitscore: 120.6, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MEDFSGRPGVAFVAGGTGGIGAAVVRTLAARGSAVVFTYRVRREA AEALADEAEGLVPLPLDLTDETATARALTATAEAYGSLHTLVYAAGPHVPMRHLSRVSP GEYRAQLEADAGAFFNLVHPALPVLRRSRGSIVAVTTVATRRFPVRDGLSSGAKGAVEA VARALAAEEGRYGVRVNCVAPGMLTDGIAGRLIESGELDDEALAVARRNIPLRRFGEAA DIAEAVSFLASDRAGFITGQALGVDGGYSV" aSDomain 18693..19013 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26690_PKS_KR.1" /evalue="2.10E-08" /label="ASD48_RS26690_PKS_KR.1" /locus_tag="ASD48_RS26690" /protein_end="115" /protein_start="8" /score="26.2" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C1" /tool="antismash" /translation="GVAFVAGGTGGIGAAVVRTLAARGSAVVFTYRVRREAAEALADEA EGLVPLPLDLTDETATARALTATAEAYGSLHTLVYAAGPHVPMRHLSRVSPGEYRAQLE ADA" CDS_motif 18705..18767 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26690_0001" /evalue="2.90E-06" /label="PKSI-KR_m1" /locus_tag="ASD48_RS26690" /protein_end="33" /protein_start="12" /score="19.9" /tool="antismash" /translation="VAGGTGGIGAAVVRTLAARGS" misc_feature complement(19585..19598) /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: weak, score: 18.39" /tool="antismash" misc_feature complement(19844..19859) /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 19.61" /tool="antismash" gene 20001..27053 /locus_tag="ASD48_RS26695" /old_locus_tag="ASD48_17170" CDS 20001..27053 /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (672-1107). E-value: 9.5e-123. Score: 402.1. Matches aSDomain: nrpspksdomains_ASD48_RS26695_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (1221-1540). E-value: 2.7e-62. Score: 202.8. Matches aSDomain: nrpspksdomains_ASD48_RS26695_PKS_AT.1" /NRPS_PKS="Domain: PP-binding (1728-1793). E-value: 1.6e-08. Score: 26.7. Matches aSDomain: nrpspksdomains_ASD48_RS26695_PP-binding.1" /NRPS_PKS="Domain: PKS_KR (2073-2295). E-value: 2.1e-42. Score: 137.1. Matches aSDomain: nrpspksdomains_ASD48_RS26695_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) hglE-KS: hglE" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) PKS_AT" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1021: malonyl CoA-acyl carrier protein transacylase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010356776.1" /locus_tag="ASD48_RS26695" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17170" /product="type I polyketide synthase" /protein_id="WP_057604243.1" /sec_met_domain="ketoacyl-synt (E-value: 1.3e-67, bitscore: 223.2, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="hglE (E-value: 1.4e-126, bitscore: 417.7, seeds: 4, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 2.8e-61, bitscore: 202.8, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 3.2e-07, bitscore: 26.1, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTSAVRSEDMIIGITPFGEPDAGLALAIDRAGGLGVLDLGSGDRR AREALSRLRRASPGAFAVRVGAHCRLTPADLEPDGPHTLVLTADTDGASWPVEGLSARY RVLVEVTDLAGARDALRAGAHGLIARGAESGGRIGELSTFVLLQQLLAAPEVAAPVWAC GGIGPRTAAAAVAGGAAGVVLDSQLALLAESALPEPAAAALRTLDGSETVVLAGHRVLL RRGPDAPRLPLDAGPQAVAALLGAQDPRGQLLPVGQDGFLAARFAERWGDVRRTLRAVR DAVLDALRDDTAVRALRAGSPMSRALGTRLPLAQGPMTRVSDGAPFAAAVAADGALPFL ALALADGARTRAMLAETRDAVAGRPWGVGVLGFAPEDVRAAQLEAVRELRPTHAIIAGG RPSQAQALERDGIRTFLHVPSPGLLRQFLEAGARRFVFEGSECGGHVGPRASFALWEAQ LAVLEDWSQGHRAEEVEVLFAGGVHDERSAAMVAALAAPLTARGAAVGLLMGTAYLFTE EAVSCGAIRPLFQRQVMAAERTTLLESAPGHATRCVPSPFAAGYRDEEARLRAEGAGDR RIWESLERLNVGRLRIASKGVTRDTDGSLTPVDEQRQLAEGMFMAGAVAVLRSTTTTVA ALHESVTTGAIGHLARRAAEWGREETVREPAAPAPLDIAVVGMACMFPQAPDLPTFWAN VVGGVDAVGEVPADRWDPAVHHGESTPSKWGGFLPRIPFDPLRYGIPPASLGSVEPVQL LSLEAARRALEDAGYGEGERAFDRSRTSVVFGAEAGSDLSNAATLRAVLPSYYGGVPAG LDDQLPQLTEDSFPGMLANVISGRIANRLDLGGANYTVDAACASSLAAVDVACKELVGG TSDVVLCGGADLHNGINDYVLFSSVHALSPTGRSRAFDGSADGIALGEGVACVVLKRLA DAERDGDRIYGVIKGLGSSSDGRSLGLTAPRPEGQRSALERAYRNAGVSPADVGLVEAH GTGTVVGDRTELRILGEVFGEAGAAPGSCAIGSVKSQIGHTKCAAGLAGLIKTVLALHT GVRPPTLHVEAPNAAWDRESSPFAFHARARPWAAPPEERLAGVSAFGFGGTNFHVVLSA HAGGVPPVRGADAWPAELFVFRGRDAAAAGRAADELLRAAEAEGRPWRLRDLALGAARR SDASGEPAQVAVVATDVDDLVGKLRRVSADPAEHDPARGIHRAGPDDPGDAKVAFLFPG QGSQRTGMLADLFVTFPELRPYLELGRAHADTLYPPAAFDDAEHDRQQAALTDTRVAQP ALGVAGLAAHAVLTAAGVRPDMAAGHSYGELVALCAAGALSPETLLELSAERATAILEA AGAAGAVGSTGPAGSTASARAGGSAGAAGGDPGAMAAVAAGADKVARALEAVRAPESVV VANRNSPEQTVISGPTDAVADTVRLLREAGVGAKRIPVACAFHSPLVAGAADRFAEALA ARPVHAPEFPVWSNRTAAPYPADADGVRTELAAQIAAPVSFAEQIEAMYAAGARVFVEA GPGSVLTRLVGQILGDRPHRTVACEPRPGGGLHGWLDALARLAVAGLPVRAGWLLRGRD AVDAVRTPVPKRPGWTVDGHLVRTAAGALLPGALAPARRVVEPERTVATVPTNPPHGVP SDRDALVSEFLRTSREMIAAQRDVLLTYFGATAGAPPAAPAAPAAPAAAVPQVIHAVPE LPTTQPAAAAATAEPAGDSAPPRATGPVDVQQVVLEIISERTGYPVDMIEPDLDLEADL SIDSIKRAEIAGELARRLGAGAGADLASMDDDELEELAKARTAAAVTDWLTARLGGPDA PVPTAGHGTAPGEATVAVAVPATEPGAPGQAVPPEVTGEPPRRHVLRPVPLDAGTDAPA APSAAPSAVPSAMLSGTRWILLGEAPEAAARLVSHGADVAVRARDHVLAEADGPVDGVL YLGALDGAGDGPVLPDAFPVLKAALARGPRWLLAVRTADGGTPDPRTAGLRGLFRTVAR EYPELVARVVDLCDASPSAVADAVVAEAVAPDRTPVVLRTAAGRHGFELVEAPLGALGS TGAGPAGDGAAEAAALGLDRDSVVLLTGGARGITAQFAATLARAARCRLELLGRTPAPD GPEAADTAAARTPAELRAVLAARGGGKPSEINRAAELLLAQREITATLAELTALGGRAR YRSVDFREPGAVLQAVKEIHAEHGRLDGVVHAAGVIEDRLVAEKSAESFQRVYGTKATG ADALLTALEDLPAAPAFTVLFGSISAVLGNRGQVDYAAANDALETLGAAFAARTGHRAV TVHWGPWAPAAGHAGMVGAELAREYARRGIRLIDPEEGTAALLRELAWGEESATAVVHT ASGW" misc_feature 20358..20360 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" misc_feature 20862..20864 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" aSDomain 22017..23321 /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26695_PKS_KS.1" /domain_subtypes="Trans-AT-KS" /evalue="9.50E-123" /label="ASD48_RS26695_PKS_KS.1" /locus_tag="ASD48_RS26695" /protein_end="1107" /protein_start="672" /score="402.1" /specificity="transATor: (unknown)" /tool="antismash" /translation="IAVVGMACMFPQAPDLPTFWANVVGGVDAVGEVPADRWDPAVHHG ESTPSKWGGFLPRIPFDPLRYGIPPASLGSVEPVQLLSLEAARRALEDAGYGEGERAFD RSRTSVVFGAEAGSDLSNAATLRAVLPSYYGGVPAGLDDQLPQLTEDSFPGMLANVISG RIANRLDLGGANYTVDAACASSLAAVDVACKELVGGTSDVVLCGGADLHNGINDYVLFS SVHALSPTGRSRAFDGSADGIALGEGVACVVLKRLADAERDGDRIYGVIKGLGSSSDGR SLGLTAPRPEGQRSALERAYRNAGVSPADVGLVEAHGTGTVVGDRTELRILGEVFGEAG AAPGSCAIGSVKSQIGHTKCAAGLAGLIKTVLALHTGVRPPTLHVEAPNAAWDRESSPF AFHARARPWAAPPEERLAGVSAFGFGGTNFHVVLSA" aSModule 22017..25379 /complete /domains="nrpspksdomains_ASD48_RS26695_PKS_KS.1" /domains="nrpspksdomains_ASD48_RS26695_PKS_AT.1" /domains="nrpspksdomains_ASD48_RS26695_PP-binding.1" /locus_tags="ASD48_RS26695" /monomer_pairings="mal -> mal" /tool="antismash" /type="pks" CDS_motif 22533..22580 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0001" /evalue="8.20E-04" /label="PKSI-KS_m3" /locus_tag="ASD48_RS26695" /protein_end="860" /protein_start="844" /score="12.0" /tool="antismash" /translation="GANYTVDAACASSLAA" CDS_motif 22956..23000 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0002" /evalue="2.90E-03" /label="PKSI-KS_m5" /locus_tag="ASD48_RS26695" /protein_end="1000" /protein_start="985" /score="10.3" /tool="antismash" /translation="VEAHGTGTVVGDRTE" CDS_motif 23061..23105 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0003" /evalue="6.50E-03" /label="PKSI-KS_m6" /locus_tag="ASD48_RS26695" /protein_end="1035" /protein_start="1020" /score="9.4" /tool="antismash" /translation="GSVKSQIGHTKCAAG" CDS_motif 23661..23711 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0004" /evalue="2.70E-05" /label="PKSI-AT-mM_m1" /locus_tag="ASD48_RS26695" /protein_end="1237" /protein_start="1220" /score="16.6" /tool="antismash" /translation="FLFPGQGSQRTGMLADL" aSDomain 23664..24620 /ASF="(Methyl)Malonyl-CoA specificity inconclusive" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26695_PKS_AT.1" /evalue="2.70E-62" /label="ASD48_RS26695_PKS_AT.1" /locus_tag="ASD48_RS26695" /protein_end="1540" /protein_start="1221" /score="202.8" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="LFPGQGSQRTGMLADLFVTFPELRPYLELGRAHADTLYPPAAFDD AEHDRQQAALTDTRVAQPALGVAGLAAHAVLTAAGVRPDMAAGHSYGELVALCAAGALS PETLLELSAERATAILEAAGAAGAVGSTGPAGSTASARAGGSAGAAGGDPGAMAAVAAG ADKVARALEAVRAPESVVVANRNSPEQTVISGPTDAVADTVRLLREAGVGAKRIPVACA FHSPLVAGAADRFAEALAARPVHAPEFPVWSNRTAAPYPADADGVRTELAAQIAAPVSF AEQIEAMYAAGARVFVEAGPGSVLTRLVGQILGDRPHR" CDS_motif 23901..24014 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0005" /evalue="2.00E-12" /label="PKSI-AT-M_m3" /locus_tag="ASD48_RS26695" /protein_end="1338" /protein_start="1300" /score="39.1" /tool="antismash" /translation="GVRPDMAAGHSYGELVALCAAGALSPETLLELSAERAT" aSDomain 25185..25379 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26695_PP-binding.1" /evalue="1.60E-08" /label="ASD48_RS26695_PP-binding.1" /locus_tag="ASD48_RS26695" /protein_end="1793" /protein_start="1728" /score="26.7" /tool="antismash" /translation="QVVLEIISERTGYPVDMIEPDLDLEADLSIDSIKRAEIAGELARR LGAGAGADLASMDDDELEEL" aSDomain 26220..26885 /ASF="KR domain putatively catalyzing D-configuration product formation" /ASF="catalytic triad S,Y,N inconclusive" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26695_PKS_KR.1" /evalue="2.10E-42" /label="ASD48_RS26695_PKS_KR.1" /locus_tag="ASD48_RS26695" /protein_end="2295" /protein_start="2073" /score="137.1" /specificity="KR activity: active" /specificity="KR stereochemistry: (unknown)" /tool="antismash" /translation="VVLLTGGARGITAQFAATLARAARCRLELLGRTPAPDGPEAADTA AARTPAELRAVLAARGGGKPSEINRAAELLLAQREITATLAELTALGGRARYRSVDFRE PGAVLQAVKEIHAEHGRLDGVVHAAGVIEDRLVAEKSAESFQRVYGTKATGADALLTAL EDLPAAPAFTVLFGSISAVLGNRGQVDYAAANDALETLGAAFAARTGHRAVTVHWGPWA " CDS_motif 26733..26822 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26695_0006" /evalue="6.00E-13" /label="PKSI-KR_m4" /locus_tag="ASD48_RS26695" /protein_end="2274" /protein_start="2244" /score="41.3" /tool="antismash" /translation="FTVLFGSISAVLGNRGQVDYAAANDALETL" gene 27062..31606 /locus_tag="ASD48_RS26700" /old_locus_tag="ASD48_17175" CDS 27062..31606 /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (7-469). E-value: 4e-116. Score: 380.3. Matches aSDomain: nrpspksdomains_ASD48_RS26700_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (633-849). E-value: 4.3e-34. Score: 110.2. Matches aSDomain: nrpspksdomains_ASD48_RS26700_PKS_AT.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_KS" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1021: malonyl CoA-acyl carrier protein transacylase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127426.1" /locus_tag="ASD48_RS26700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17175" /product="type I polyketide synthase" /protein_id="WP_063887501.1" /sec_met_domain="ketoacyl-synt (E-value: 5.2e-64, bitscore: 211.5, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 4.2e-115, bitscore: 380.3, seeds: 2284, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 4.5e-33, bitscore: 110.2, seeds: 1682, tool: rule-based-clusters)" /transl_table=11 /translation="MAARHRPVAVVGMAVLLPGAADLDAYWRNLRDGVDAIGEVPEGRW DAAYYRPGTAAEPAVADRVYARRGGFVDGLAEVEVTRFGIMPHSVAGTEPDQLIALHVA SAALDDAGGPDRLPDRGRVGVVLGRGGYLGPGLVRLDQRVRTAGQLVHTLGELLPDLTT DQLGRVRAAFTERLGPDSPESAIGLVPNLAASRIANRLDLRGPAYTVDAACASSLVAVD QAVGELGSGRCDLMLAGGVHHCHDITLWSVFSQLRALSPSQRSRPFHRDADGILIGEGT GVVVLKRLADAERDGDRIYAVIRGTGVASDGRAAGLVNPDPGGQAQAVRQAWRAAGLDP AEPGSIGLLEAHGTATPAGDEAELATLAEVFGPGDGEAVLGSVKSMIGHTMPAAGVAGL VKAALAVHHGTLLPTLHCDDPHPALARTRFRTLEKAADWETTERQPVRRAAVNAFGFGG INAHVVLEEAPGTRGSRASGTRGSRAAAPPRPALAVTEPEQVLLLAADSPARLAALLDA DDAAVRAAGLAPSHPHPDAGPARLGIVDPTAKRLALARRAVGKRRAWHGRSDVWFRPSP LLGAEGGGPAFLFPGLEGDFAPQVDDVAAHFGLPAPSVGGDRTGDVGRHGFGVVAVGRL LDAALRRGGIVPSAVAGHSVGEWTAMATAGLYSGDEVDAFMADFDPDSVSVPGLAFGAI GASAERVLAALRDGGPATAGVVLSHDNAPGQSMVCGPQAAVEEFVRAFRAQGVLSQVLP FRSGFHTPMLEPHLGPIKEAADRFRLRPPHTPLWSGTTAAPFPEDEAGIRSLFVRHLLE PVRFRQLTEALYASGHRVYVQVGPGQLGSLVGDTLGGRDHLVVAANSPHRTGLAQLRRV ATALWTAGAAVAPSLEPSVASSPGPSPTSAAAERTARPPVRLDLGGALVSLAPQRLTAL RAELRAPVRAAGPAGPSPLDALAGDSPMAAELSALLHETADTAAALMTARAGAVAAARP TGPWHGSVHVSPDTMPYLLDHCFFPQRPGWPEVADRWPVVPATTIVRHIVDAAADAARD AAPGTVPVAVHGARFEEWLTATPAVDVPVTVTAEGSGRLAVSFGPRARATVELAAAHPP PPAPWPVEPVTERAPEHTAAQLYDERWMFHGPAFQGVTELTAIGDRHIRGVITTPYAPG ALLDNVGQILGYWIMATHAERTVVFPVGMREMRFHGPHPAPGTEVGCLVRITSLTDAFL EADVQLTAGGTVWAELSGWQDRRFDNDPRTRPVERFPERHTLSETRPGGWQLLHERWPD LASRELIMRNSLGGAERSQYAQHAPRGRRQWLLGRIAVKDAVRQWLWDQGEGPVFPAEL RVHNDEAGRPYVTGVHGRVLPALDVSLAHCAEAGVAIVRPHTPGPGPGIDIEEVTDRTP QTLAAALGEDELRLLRDLSAGSGDSEALWFTRFWAAKEAVAKAEGTGFEGRPRDFTVFD ATPAGDRLTVAGRLERAWPVHCAPAANPPRLPERSYVVAWTTGHPTAEEYDAR" aSDomain 27083..28468 /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26700_PKS_KS.1" /domain_subtypes="Hybrid-KS" /evalue="4.00E-116" /label="ASD48_RS26700_PKS_KS.1" /locus_tag="ASD48_RS26700" /protein_end="469" /protein_start="7" /score="380.3" /tool="antismash" /translation="VAVVGMAVLLPGAADLDAYWRNLRDGVDAIGEVPEGRWDAAYYRP GTAAEPAVADRVYARRGGFVDGLAEVEVTRFGIMPHSVAGTEPDQLIALHVASAALDDA GGPDRLPDRGRVGVVLGRGGYLGPGLVRLDQRVRTAGQLVHTLGELLPDLTTDQLGRVR AAFTERLGPDSPESAIGLVPNLAASRIANRLDLRGPAYTVDAACASSLVAVDQAVGELG SGRCDLMLAGGVHHCHDITLWSVFSQLRALSPSQRSRPFHRDADGILIGEGTGVVVLKR LADAERDGDRIYAVIRGTGVASDGRAAGLVNPDPGGQAQAVRQAWRAAGLDPAEPGSIG LLEAHGTATPAGDEAELATLAEVFGPGDGEAVLGSVKSMIGHTMPAAGVAGLVKAALAV HHGTLLPTLHCDDPHPALARTRFRTLEKAADWETTERQPVRRAAVNAFGFGGINAHVVL EEAP" aSModule 27083..31839 /complete /domains="nrpspksdomains_ASD48_RS26700_PKS_KS.1" /domains="nrpspksdomains_ASD48_RS26700_PKS_AT.1" /domains="nrpspksdomains_ASD48_RS26705_PP-binding.1" /locus_tags="ASD48_RS26700" /locus_tags="ASD48_RS26705" /monomer_pairings="mxmal -> mxmal" /monomer_pairings="mxmal -> mxmal" /tool="antismash" /type="pks" CDS_motif 27311..27391 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26700_0001" /evalue="1.30E+01" /label="PKSI-AT-mM_m3" /locus_tag="ASD48_RS26700" /protein_end="110" /protein_start="83" /score="-0.9" /tool="antismash" /translation="GIMPHSVAGTEPDQLIALHVASAALDD" CDS_motif 27674..27721 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26700_0002" /evalue="1.40E-05" /label="PKSI-KS_m3" /locus_tag="ASD48_RS26700" /protein_end="220" /protein_start="204" /score="17.2" /tool="antismash" /translation="GPAYTVDAACASSLVA" aSDomain 28961..29608 /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26700_PKS_AT.1" /evalue="4.30E-34" /label="ASD48_RS26700_PKS_AT.1" /locus_tag="ASD48_RS26700" /protein_end="849" /protein_start="633" /score="110.2" /specificity="substrate consensus: mxmal" /specificity="PKS signature: (unknown)" /specificity="Minowa: mxmal" /tool="antismash" /translation="RLLDAALRRGGIVPSAVAGHSVGEWTAMATAGLYSGDEVDAFMAD FDPDSVSVPGLAFGAIGASAERVLAALRDGGPATAGVVLSHDNAPGQSMVCGPQAAVEE FVRAFRAQGVLSQVLPFRSGFHTPMLEPHLGPIKEAADRFRLRPPHTPLWSGTTAAPFP EDEAGIRSLFVRHLLEPVRFRQLTEALYASGHRVYVQVGPGQLGSLVGDTLGG" CDS_motif 28991..29068 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26700_0003" /evalue="2.40E-09" /label="PKSI-AT-M_m3" /locus_tag="ASD48_RS26700" /protein_end="669" /protein_start="643" /score="29.2" /tool="antismash" /translation="GIVPSAVAGHSVGEWTAMATAGLYSG" gene 31603..31929 /locus_tag="ASD48_RS26705" /old_locus_tag="ASD48_17180" CDS 31603..31929 /NRPS_PKS="Domain: PP-binding (24-79). E-value: 6e-10. Score: 31.3. Matches aSDomain: nrpspksdomains_ASD48_RS26705_PP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127425.1" /locus_tag="ASD48_RS26705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17180" /product="acyl carrier protein" /protein_id="WP_057604244.1" /sec_met_domain="PP-binding (E-value: 1.7e-07, bitscore: 26.9, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTPPTPHTPVTADERSVLADLTGMLTRLLEDEYGLDDIEIDLQTT FNRDLELESIDLVTLAGLLQERYGDRVNFAEFLAGMEFDEIIELTVGRLVEYVVTSLKA AEAS" aSDomain 31675..31839 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26705_PP-binding.1" /evalue="6.00E-10" /label="ASD48_RS26705_PP-binding.1" /locus_tag="ASD48_RS26705" /protein_end="79" /protein_start="24" /score="31.3" /tool="antismash" /translation="LTRLLEDEYGLDDIEIDLQTTFNRDLELESIDLVTLAGLLQERYG DRVNFAEFLA" gene 31933..32748 /locus_tag="ASD48_RS26710" /old_locus_tag="ASD48_17185" CDS 31933..32748 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (26-131). E-value: 3.3e-28. Score: 90.9. Matches aSDomain: nrpspksdomains_ASD48_RS26710_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036: alpha/beta hydrolase fold protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127424.1" /locus_tag="ASD48_RS26710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17185" /product="alpha/beta hydrolase" /protein_id="WP_057604245.1" /sec_met_domain="PF00561 (E-value: 7.8e-25, bitscore: 83.2, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 2.8e-21, bitscore: 72.4, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MAMVDTGTVRLHVQRIGPRQGRPATATVVLVHGLLTDSLASYYFT VAPAFAAAGLDVVMYDLRGHGRSERPTAGYALDDNVDDLEALLDRLGVSGPVHLVGNSY GGTIAFGYAARHPERAASVSLVESEPATAAWAVKLGGILDRVVTQLARNESDAIAWITA NRGHNTARLAKGAARLARETSLGRDIPASRVLTDNQIAAVRCPVLGLYGADSDLAELAP WLRAVLPDCRTVVIPGHEHSVLVEASGTVGGHILSLVDEAGRVAAEATG" aSDomain 32011..32325 /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26710_Abhydrolase_1.1" /evalue="3.30E-28" /label="ASD48_RS26710_Abhydrolase_1.1" /locus_tag="ASD48_RS26710" /protein_end="131" /protein_start="26" /score="90.9" /tool="antismash" /translation="TVVLVHGLLTDSLASYYFTVAPAFAAAGLDVVMYDLRGHGRSERP TAGYALDDNVDDLEALLDRLGVSGPVHLVGNSYGGTIAFGYAARHPERAASVSLVESEP A" CDS_motif 32212..32274 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26710_0001" /evalue="3.40E-06" /label="NRPS-te1" /locus_tag="ASD48_RS26710" /protein_end="114" /protein_start="93" /score="19.6" /tool="antismash" /translation="SGPVHLVGNSYGGTIAFGYAA" gene 32745..33920 /locus_tag="ASD48_RS26715" /old_locus_tag="ASD48_17190" CDS 32745..33920 /GO_function="GO:0016757 - glycosyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) MGT" /gene_functions="biosynthetic-additional (smcogs) SMCOG1062: glycosyltransferase, MGT family" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127423.1" /locus_tag="ASD48_RS26715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17190" /product="glycosyltransferase" /protein_id="WP_057604246.1" /sec_met_domain="MGT (E-value: 1.6e-39, bitscore: 131.5, seeds: 193, tool: rule-based-clusters)" /transl_table=11 /translation="MSRFLFVVPPLVGHLNPAVGVAAELTARGHRVAWACADPELVGRL AGPGAGTVFPCGGAPPGERPADLRGPQALKFLWEWYLLPLAEAMAPGVRAAVEAFRPDV VVADQQAFAGALVAERLGLPWATSATTSAEFTDPLAGLPKVGEWLDRRLAGLRSAIGDP AGDADPRFSPHLVLAFSTPELAGEAHDGVRWVGPSVTARPSAAGFPWEWLDDGRATVLV TLGTANTDVGGRFLEVCRDVLRERADRVQGVIVDPGRTLQPRGEDKDLLILPSVPQLAL LERLEKASGAVLCHAGHNTVCEALWHGVPLVVAPIRDDQPVVAGQVTDAGAGLRVRFGR VTVRQLGAALDSVLDEPGYRAAADRIRTAFRAAGGSSTAATHLEDLAREFG" gene 33917..34984 /locus_tag="ASD48_RS26720" /old_locus_tag="ASD48_17195" CDS 33917..34984 /EC_number="2.1.1.-" /GO_function="GO:0008168 - methyltransferase activity [Evidence IEA]" /GO_function="GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127422.1" /locus_tag="ASD48_RS26720" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17195" /product="class I SAM-dependent methyltransferase" /protein_id="WP_199875964.1" /transl_table=11 /translation="MTEENRTAERIAEARPAYRADIAAGLDRFFEPRRTNCPWCGSAAL TTRLRTTDLLQHKPGRFVLDRCESCGHTFQNPRLTAEGLEFYYRDFYDGLGEKKLGDTF GGRTKMYRGRAGSMLPHDPAPKTWLDVGTGHGHFCAAAREVLPGTTFDGLDFTDGVELA EREGRVAHGYRGAFPELAPGLAARYDVVSMFHYLEHSTDPDRELRAAHETVRPGGHLLI EVPDPESRYARLLGRWWLPWLQPQHLHFVPVANLRERLTLLGFTVLAEQHAEPHDPVDL LAAVWLALDHAAPRDDAPWLPEPPGALRRTLRAAMLVAGIPALIVGTLLDRFAVRPLSH RLGVSNAYRIVARRD" gene 35085..36038 /locus_tag="ASD48_RS26725" /old_locus_tag="ASD48_17200" CDS 35085..36038 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1066: alpha/beta hydrolase domain-containing protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127421.1" /locus_tag="ASD48_RS26725" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17200" /product="alpha/beta hydrolase" /protein_id="WP_057604247.1" /transl_table=11 /translation="MSLLARPAVAALAAKTMQGLTGLASRRSGGPGPTAGGQARFPEYP RVVRELTVPTSVAPAQVTVYEPPAGTATPAPVHVNFHGGGYVVSMPELDDGLCRWLAAE AGVVVVNVKYVVAPQHPFPAPPTQAFEVVRWVAEHGAEHGWDGGRLTVGGQSAGGGLTA AVARQALEQGGPAIALQVLHYPPLDLATSAKDKKAAVAKPLLRPWMAEIFDTSYVPDPR ERAHRFVSPAHASDTADLTGIAPALVITAEYDLLRDEGVRYAERLDAAGALVGHHDLAG ADHGYDTKDDERARTTYALIARHLRRATGAGTSRAS" gene complement(36169..37248) /locus_tag="ASD48_RS26730" /old_locus_tag="ASD48_17205" CDS complement(36169..37248) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127420.1" /locus_tag="ASD48_RS26730" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17205" /product="Ldh family oxidoreductase" /protein_id="WP_057604248.1" /transl_table=11 /translation="MSTLTPPPKILVPAEDLRTFSAALLEKGGLRAEHARTTADVFVWA ALRGVDSHGIARVPAYLDLLEKGVANADARITVESTTPAAAVLDADRAPGPVALSAAAD EAVTRARTTGVAAVGVRRTVHTGAIGYYVSRIAEQGLVGIGFVAGMPNMGYTGVRGAAV ATSPLAIAVPTDSSSAHAPLLLDMATATVALGRIRQARASGTPLPEGAAATEDGTPTTD PEKAVMPLPLGGAKGSGMSLAFELLTSVLVGAPIFASFHSDDPAGRKHRQNALLIAVDP AAFGGAEAFAASVDATLDTLKGLPAADGAQGVFYPGERSAAVAEGRGKKGVPVAPKVWR DLTERAGKLGVALPEAAGQ" gene complement(37268..38986) /locus_tag="ASD48_RS26735" /old_locus_tag="ASD48_17210" CDS complement(37268..38986) /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /GO_function="GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) TPP_enzyme_N" /gene_functions="biosynthetic-additional (rule-based-clusters) TPP_enzyme_C" /gene_functions="biosynthetic-additional (smcogs) SMCOG1055: pyruvate oxidase/decarboxylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019069944.1" /locus_tag="ASD48_RS26735" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17210" /product="thiamine pyrophosphate-dependent enzyme" /protein_id="WP_057604249.1" /sec_met_domain="TPP_enzyme_N (E-value: 3.6e-32, bitscore: 106.6, seeds: 75, tool: rule-based-clusters)" /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-23, bitscore: 77.5, seeds: 323, tool: rule-based-clusters)" /transl_table=11 /translation="MTDTTTAPGADGGDALVTAFNAAGADYLFCSSGSEWAPVWESLAR RHRDGLPCPRYLDLTHETVAVGMATGYGLVSRRPQGVLLHAAPGLLQGSMAVHGALLAG VPMVVSSSESTTYGDGPGQDPGGQWYRNLSIVGGPHGVAAPFTKWSTEAASVHTLPTMV TRAAELAWRAPAGPAYLNVPLEILLEDWDGREAKPIVPPGSTHSSPEEADAVARLIREA RNPVVVTETAGREAGGFEALLAFAEAWNIPVVEPDSAVCGNFPRTHPLHAGSDIGPWMD EADLILLVNCRAPFYPPSRRPSKARVVVIDEVPQRPHVVYQVLFADAYLEGNVANTLRQ LAKRAKDLDEAAVAVRRTAQDERHAAEQTAIADAEARAGAQRQTEGVDPVLVAATLREL LDGADGVVVDETITHSRVVKRHLRTADPDSYFYVQGGLGQGIAVALGVKLAAKDRPVVL TIGDGAFTYNPVVASYDASRAYELPLLIVVFNNRVYKSMNLNHRRFYPDGAAAQTGEWL GTDLHRLPRLARFAEPFGMHTETVDTAQALGPALERALKAVAEGTTAVVDVLVTR" gene complement(39000..39860) /locus_tag="ASD48_RS26740" /old_locus_tag="ASD48_17215" CDS complement(39000..39860) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019927636.1" /locus_tag="ASD48_RS26740" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17215" /product="amidohydrolase family protein" /protein_id="WP_054241279.1" /transl_table=11 /translation="MFVVDTQIHIWLEETPDRPWVPGARERIRLNGHREDPFSYEEALE LMDEAGVNRALILPPSWEGDRIDYALEACEAHPDRFGIMARIPQNKPEEGKAMLKDFAQ NPHIKGTRLTFHRPQDRNWMIDGTNDWYWPVAAELGIPTMVHAPIWKRELGEIAAKHPE LKIIIDHMGIMARCVDDAIGYWVAETADLAAHPNIYVKVSALPGYSTQPFPNNNIQKYV REMVDKMGPQRCFYGTDITRLLGHGITYTDTIEQFTKHWDFTPEELEWIMGRGISEVLN WPIEG" misc_feature complement(40019..40030) /note="TFBS match to CcpA, Catabolite control protein A, confidence: medium, score: 17.48" /tool="antismash" gene complement(40250..41461) /gene="lhgO" /locus_tag="ASD48_RS26745" /old_locus_tag="ASD48_17220" CDS complement(40250..41461) /EC_number="1.1.3.-" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene="lhgO" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1103: FAD dependent oxidoreductase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127417.1" /locus_tag="ASD48_RS26745" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17220" /product="L-2-hydroxyglutarate oxidase" /protein_id="WP_057604250.1" /sec_met_domain="DAO (E-value: 1.9e-64, bitscore: 213.7, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MADETIGIVGGGIVGLATAREIALSRPGTRVVVFEKEREVALHQT GHNSGVVHAGIYYTPGSLKAELTVRGVALLRAYCQDRELPYREIGKLVVAVREDELGRM NALYDRARNNHVPELRKVSREEIREIEPNAGGVAALYSPRTAITDYPAIARAFAEDVAG SGGEVRTGFPVTSLTEVPGGIEVASGPRRERVDRLILCAGLHSDTVAGLAQDRQEPRIV PFRGEYMLLRPEKTDLVRGLIYPVPDPRYPFLGVHFTPRVDGSVEVGPNAVLALAREGY TRTRVSPKDLFGLAAYPGVWRMAARHWRTGVKEYRGSFSAAAFMKDAKLYVPAVGVQDV VRGGAGVRAQALDRDGTLVDDFRIHRVGRVTAVRNAPSPAATASMAIAEHIVEAVFDRA SGNS" gene complement(41499..42947) /locus_tag="ASD48_RS26750" /old_locus_tag="ASD48_17225" CDS complement(41499..42947) /EC_number="1.2.1.-" /GO_function="GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aldedh" /gene_functions="biosynthetic-additional (smcogs) SMCOG1017: aldehyde dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127416.1" /locus_tag="ASD48_RS26750" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17225" /product="aldehyde dehydrogenase family protein" /protein_id="WP_057604251.1" /sec_met_domain="Aldedh (E-value: 9.6e-156, bitscore: 514.1, seeds: 89, tool: rule-based-clusters)" /transl_table=11 /translation="MRTLETLVGGEWVASAEWIDVLDPADVRTPVARVPALTAKDVTRA FDHAERGFAVWKRTSPFERARIFTDAARLIRERVEEIAADVTAENGKTLTEATGETLKS ADFLEYYAGLARQGYGTLLHDVRPNHRTHTQREPIGVILVISPWNDPLITPARKLAPLL ATGNAAVFKPATETPVSGLHFARALHEAGLPAGVLNVVTGRTAEIEEALLDDPRIVGIT FTGSNAVGNRIRRRLADRNVRFQGELGGKNASVVLKDADLPAAAKAVVAASFGQAGQRC TATSRVVVERPVYEEFTRLLVAEVEKLKVGPGSDPATTLCPLSSPRQRDSVLAHLAGAV EQGATVLTGGHADTEGERAHGCYVRPTVLGDVTPQTAIWREEVFGPVLVLRAVDGFDAA VEAVNDSGFGLAAAVFTRDLASAHRFADEAECGQVAVNSTTTGWDVHLPFGGFHDSGTA YKEQGEEVLRFSTRVKTVAVHFGG" gene 43138..43425 /locus_tag="ASD48_RS26755" /old_locus_tag="ASD48_17230" CDS 43138..43425 /EC_number="1.-.-.-" /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019056994.1" /locus_tag="ASD48_RS26755" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17230" /product="putative quinol monooxygenase" /protein_id="WP_057604252.1" /transl_table=11 /translation="MPYAVVAHYRCAPADESTVRAALLRVREHTRAEPANEGYEVHAVE GQPGGFLLYERYADRAGFEAHKAAEHFQQLIVATVWPLLTDRTVTFAEAL" misc_feature 43155..43171 /note="TFBS match to NtrC, Nitrogen regulatory protein C, confidence: medium, score: 22.03" /tool="antismash" gene complement(43520..44548) /locus_tag="ASD48_RS26760" /old_locus_tag="ASD48_17235" CDS complement(43520..44548) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019069939.1" /locus_tag="ASD48_RS26760" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17235" /product="methionine synthase II (cobalamin-independent)-like protein" /protein_id="WP_057604253.1" /transl_table=11 /translation="MADTFNYRIDHHGSLVRPAELVAARAAGDPQARTAAERKAVEEAV VLQRRLRSTVVTDGDFPREDFRGAVLDAVTGFRRTDEVGADGLAVRVAESLPKANGPLL ADWADRLTALTVIAPKVSLPSPAYLAATTYRPGLGVSSARELGEALAEIIQAEIELLVS KGVRLIQLNNPLLLGQLATDPADPGALSFEDALAVEALAVRLDTRPEGVRIGVAPGFTA PGTVDRARAGRLYGAVPADRWILPFDQGTDAELDLVRALPEDRDVCLGVVDATVPELED IDTVMARIDAAGEVKDLEDAAVSPSRGFADVASRPLLTSEEQRRKLVLVETVARYVWGN EF" gene complement(44552..45028) /locus_tag="ASD48_RS26765" /old_locus_tag="ASD48_17240" CDS complement(44552..45028) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014049791.1" /locus_tag="ASD48_RS26765" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17240" /product="heme-binding protein" /protein_id="WP_057604254.1" /transl_table=11 /translation="MSSLTLAAAEEIIEAATRRARAVGKAVSVAVVDAGGFPVAVRRAD GARPLTPDIARAKAYTAAVMQRPGTMLKKWQESQPVFFAQLSQLPGAAMPIMAAEGSVT IKKDGEIIGGLGIAGGTAGEDQTIADEVLASLGYELEFAAWGVAGGPAGPGKDA" gene complement(45025..45810) /locus_tag="ASD48_RS26770" /old_locus_tag="ASD48_17245" CDS complement(45025..45810) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (19-239). E-value: 9.4e-23. Score: 73.0. Matches aSDomain: nrpspksdomains_ASD48_RS26770_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1262: haloalkane dehalogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019069937.1" /locus_tag="ASD48_RS26770" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17245" /product="alpha/beta hydrolase" /protein_id="WP_057604255.1" /sec_met_domain="PF00561 (E-value: 4.2e-17, bitscore: 57.9, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 5.8e-19, bitscore: 64.8, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MPLADSDGTSLYYERHGSGPAILFVHGSGGHHAAWWQQVAALRDE FTVVTVDLRGFGNSDSSMPEFDGQDFPGDVVAVLDQEDLTDVMLVGQSIGSVAALRAGL LRPGRVSCVVLGHSLGGISHPELRELAAADRAEAVKLPVIDRLLTKAFQRNRADLTFLF QQMGTFNVARMQDLRNLDTNGPSLEEIEASGVKVAFLAGENDAVLSVKTVTRAHELLAG SHLEIVPGAPHSMYWETPRAYNEAVARLRRTLTAPKEAT" aSDomain complement(45094..45753) /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS26770_Abhydrolase_1.1" /evalue="9.40E-23" /label="ASD48_RS26770_Abhydrolase_1.1" /locus_tag="ASD48_RS26770" /protein_end="239" /protein_start="19" /score="73.0" /tool="antismash" /translation="PAILFVHGSGGHHAAWWQQVAALRDEFTVVTVDLRGFGNSDSSMP EFDGQDFPGDVVAVLDQEDLTDVMLVGQSIGSVAALRAGLLRPGRVSCVVLGHSLGGIS HPELRELAAADRAEAVKLPVIDRLLTKAFQRNRADLTFLFQQMGTFNVARMQDLRNLDT NGPSLEEIEASGVKVAFLAGENDAVLSVKTVTRAHELLAGSHLEIVPGAPHSMYWET" CDS_motif complement(45445..45552) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS26770_0001" /evalue="3.40E-02" /label="NRPS-te1" /locus_tag="ASD48_RS26770" /protein_end="122" /protein_start="86" /score="6.9" /tool="antismash" /translation="VMLVGQSIGSVAALRAGLLRPGRVSCVVLGHSLGGI" gene complement(45837..46208) /locus_tag="ASD48_RS26775" /old_locus_tag="ASD48_17250" CDS complement(45837..46208) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019069936.1" /locus_tag="ASD48_RS26775" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17250" /product="VOC family protein" /protein_id="WP_054241285.1" /transl_table=11 /translation="MSAEPRYIHHVNFPTTDSDRTAEWYTKVFGMKRIMPKSNTRVVLM TRGNFDLHFTPVEEMERMAPYHFAVEVDDWDDFLAHLDELGIRHTRTIERPENQSKFCY IHDPDHTMIEIVHHAKRRD" gene complement(46205..47011) /locus_tag="ASD48_RS26780" /old_locus_tag="ASD48_17255" CDS complement(46205..47011) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019069935.1" /locus_tag="ASD48_RS26780" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17255" /product="fumarylacetoacetate hydrolase family protein" /protein_id="WP_057604256.1" /transl_table=11 /translation="MRYARLSVGGRARWGRVGETDVELLSGSPLEGDAGRPDPEVVGTV RRDTADWLPPVVPPVFYAVGLNYPRHIEHAARLGNPAAVLPDRPEVGYRANNALTGHRS PIVKPAEVEGRFEAEPELVAVIGRTIRHASYEEARTAVFGWTIGNDVSARTWQHQDRTF WRSKNSDTFKPMGPWIETDVDALAQRTTLRVNGEERASFPTGDMVFDPFDFIVEITRHI TMRPGDVLWMGAESTCGIEPGDTVEVEIGGIGVLSNPVHLEGNHQS" gene complement(47008..48456) /locus_tag="ASD48_RS26785" /old_locus_tag="ASD48_17260" CDS complement(47008..48456) /EC_number="1.2.1.-" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aldedh" /gene_functions="biosynthetic-additional (smcogs) SMCOG1017: aldehyde dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127409.1" /locus_tag="ASD48_RS26785" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17260" /product="NAD-dependent succinate-semialdehyde dehydrogenase" /protein_id="WP_057604257.1" /sec_met_domain="Aldedh (E-value: 3.5e-157, bitscore: 518.8, seeds: 89, tool: rule-based-clusters)" /transl_table=11 /translation="MTTDHGYPAVRLHIAGEWCQGGTGRTAPIVNPATEEVIGDVPLAD PADLDRALEAAAAGFRVWRATPVAERTDILHAAAGLLTERAAEVGRIMTLEQGKPLAEA TGEARRVAGTLRWHADDARRAYGRIIPAEPGTLLTVRREPIGPVAAFVPWNFPAGGPMR KISAALAAGCSIVIKASEETPATAMELVRCFTDAGLPAGVLNLVFGEPAEVSAHLIASP LVRLVAFTGSVPVGKLLAAQAGQVMKPSLMELGGHAPVIVCADADPVRAARKAARAKFA NAGQVCTSPSRFLVHESLVTEFTAEFVKAAEAVVVGDGLEPGTTMGPLANERRLKSLER LTADAVARGAKILTGGDRPDRPGWFFAPTVLTDVPEDAELLHEEPFGPIAPIVPFSDLD EAVALANALPYGLAAYGFTDSAATAEKLSAELEAGILSLNHCGGSVHEAPSGGVKDSGY GREGGPEALDAYLVTKRVSHQLAP" gene complement(48503..49423) /locus_tag="ASD48_RS26790" /old_locus_tag="ASD48_17265" CDS complement(48503..49423) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127408.1" /locus_tag="ASD48_RS26790" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17265" /product="VOC family protein" /protein_id="WP_057604258.1" /transl_table=11 /translation="MGIQRIESVTYGIDDLDECVRFFDDFGLFLLERTEEHAVFETRTG QTLHLDTAPSPLLPPPVEDGPTLREVVWGVDTTAELTRLAAAAGRRRPVRESADGVLHT ADRSGFGVGLTLARPKPVTVAARPANATGGVHRWNTPLEPLTRAYPLRMCHVALNIAKA GKDEAVAFYTDVLGFRPTDIVEPMGVFLQAPGDDDQHTMLLCHRPDRAGVNHIAYEVPG FDDVVEGGNHMIEKGWREARRLGRHTIGSNVFRFLHAPCGGRVEYAADMDRVDDTYETR VHETTPPHHIWALRTNRDQDATTAS" gene complement(49533..50441) /locus_tag="ASD48_RS26795" /old_locus_tag="ASD48_17270" CDS complement(49533..50441) /GO_function="GO:0001216 - DNA-binding transcription activator activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1031: LysR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127407.1" /locus_tag="ASD48_RS26795" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17270" /product="LysR family transcriptional regulator" /protein_id="WP_057604259.1" /transl_table=11 /translation="MDRLLLMHSFVTVAQAGSFNGAAKKLGSSGSLVSRHVAELERQVG VRLVNRTARSVSLTEPGLRYAEFAARILEEIEAQDAALADSHDRAEGTLSIICPKWIGS LDLGDAIAAFSAAHPKIQVRFELGGMSDRTYDFLDSGFDVAFHTRDLRDSSVRLKKISS LPFVLCGSADYIERRGGLAHPNDIAGHDCLVHVNDPVWRIGHGHASTLHKIRNIAFSSN SYLALQKAAVHGRGIALLPQRPAYDDLVSGALQVLLPELAVPDRPLYAIYGPGQDTPRK ISVFLDFLSEWFSQNPIPAIR" misc_feature complement(50407..50422) /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 18.15" /tool="antismash" gene complement(50544..51497) /locus_tag="ASD48_RS26800" /old_locus_tag="ASD48_17275" CDS complement(50544..51497) /codon_start=1 /gene_functions="transport (smcogs) SMCOG1205: ABC transporter, carbohydrate uptake" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020127406.1" /locus_tag="ASD48_RS26800" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_17275" /product="sugar ABC transporter substrate-binding protein" /protein_id="WP_057604260.1" /transl_table=11 /translation="MRLSARSRRALFATVTGSALVLTGCGNGDSGSGSTDSVSLGFVNG GDTNFHSCLQKAVEGQAKTAGAKVYTANSHQNAGTELSNIEDMISRNVSALIVQTVNVD ALKGDIAKAKASGIPIYLTSVSTSDAGDILGAAVVDLKKVGSLDAGWIAQDAGTKEVQV GIVAGAPGAASDLLVGGFKGALPATAKVVADQPGMFNPAKAQDVAENMIQANPGLDYAF VANEEMAFAVRKAFDAAGAKNVKIVTVNGTDEGLTAVKNGEFSATVANSAKTIGETAVT NAVGLLGKEKVDKIANIPLLLVTKDNLSEAPQYCPK" misc_feature complement(51498..51512) /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 17.29" /tool="antismash" ORIGIN 1 ggacggcgac gacgagcgca cggccgccct cctcgaccgc gcggagggca tctggcgggg 61 cgaggcgctg gccggactgc ccggactgtg ggccgagacc acccgccgga cgctggcgga 121 gcggcggctg ggcgcggccg tctcccggat cgccgcctcc ctccggctcg gccggtacac 181 ggaggtgacc gccgagctgt ccgccctggt cgaccggtgt ccgggcgacg agacgctggc 241 gggtcagctg atgctggcgt actacggcgg cgcccggtac accgacgcgc tgcgggtcca 301 ccaggagacc cgtcggatgc tgatgacgca gtacggctcc cgcccgggcg ccgagttgga 361 ccgcatccat cgcgggatcc tcgaccgggt gccggccgcc gatctcgtcc ggggccgcac 421 ggccgcgccc cgcccggccc gcccggtcgc ggccccgccg ccggaccgcc cgcgcccgcc 481 gaggaacctg ccgcatcagc cgcccctgat cggccgtcac gccgaactgc gggccctcag 541 cgccgcggcc gacgcggcgg cggagcaggg ccgggtgatc agcctggagt ccgtcagcac 601 cgtcagcggc atggccgggg tgggcaagac cagcctggcc gtgcacggcg cgcaccggct 661 ggccgagcgg ttccccgacg cccagctgta tgtggacctg cgtggccact cccccgtcgg 721 cgaaccgctg ggtcccggcg cggccctggc caccctgctg cgtctgctcg gcacgccggc 781 ggacaccatc ccggtcgagc tggagggccg taccgcgctg tggcagaccg tgctggccga 841 gcggcgggcg gtgatcgtcc tggacgacgc ggtgagcgcc gaccagatcc gcccgctgct 901 gccgagcggc tcgcccaccc tggccatcgt cacgagcagg cgccggctga cgggcctgcc 961 gcaggcccgg cacatcccgc tcgacgtgct cccgaccgac gacgccatcg ccctgttccg 1021 cgcctgcgcg ggcgaggaac gcgccctgga catccgggag atcaccacga tcgttcgatt 1081 atgcggccat ctcccgctcg cgatcgaact ggtcgcgagc cgcttccgcg cccatcccgc 1141 ctggacgctc ggcacgctgg ccgaccgcct gacccgcgcc gagggacggc tgggcgagat 1201 cagggatgcc gagcaggagt tgctgcgggc cttcgacctg acgtaccgga ccctcacgcc 1261 ggagcagcgc gccgcgttcc gccggctcag tctgcactcc ggcccggact tcacggtgga 1321 ctcggcggcc gcctccctgg acctgcgccc ggccgccgcg gaacgcgtgc tggaagcgct 1381 gctgacgtgc catctgctcc acgagccgac cccggaccgg taccggttcc acgacctgct 1441 gcgcgagtac ggccactcca ggtcccgcgc cgacgacacc gacgaggagc gcgccgacgt 1501 cctccggcgc ctgacggact tccacgtcga cgccgccgac cgcgccgacc gtctcgcgta 1561 cccccgccgc acgaggccgg cgccgccgcg cgagcgcggc cccggcgcag cgctgcccga 1621 ctggcccgac gccgtggccg cgcggtcctg gctggccgcc gagcgcgcga acctgctggc 1681 caccgaacgc cgggcgcgcg gccagggccg ccccggggcg gccgcccgac tcgccttcgc 1741 catggccggc ttcctcgacg aggagtgcca ctggctcgac gccgaggccg tcctggagac 1801 cgccgtcgag cactggacgc ggacgggcga gcaggccgcg ctgtgccgtg ccctgctgca 1861 cctcagcgcc gtccacgcgc acaccgcgcg ctacccggag gccgccgaga gcggcgaccg 1921 ggctctgcgg atcgcccgtg cgacggggga cggggaggcg gaggccgagg tgctgcgcac 1981 gctcggcacc ctgaactggc acgtgggcga ccatcaggcg gcgctcgtcc tcttccagaa 2041 gtcgttcgcg atcaccgcgg tgtccggcga ttccctggac cgcgcgcgcc tgcacaacaa 2101 catggcggtc accctcctct ttctcgggga gtacgaccgt gcgctggaac acttcgagaa 2161 gacgctcagc ggattcaccg aggcgggcga tcacgcggcg ctcggaaaga cgctcaacaa 2221 catcggcgat ctgcatctgc gtcgcggaga cctggaatcc tcgcgccggt ctttcgagga 2281 agcactgaca ttcctggaac attccggtaa ccgctacgac cgcgccaccg tgcgcggcag 2341 cctggccgat gtcctcacgg aatcgggcga catcaccgca gctctccccc tttatcagga 2401 gaccctcgcg gaattccgcg cgctgggcga ccggaagagt caggccgaca cgctgatcgg 2461 tctgggcgag gcacagcgga aagcggggga tcccggtaag gccgtacggt atttcctgga 2521 tgctctcgac atcgcccgcc tgatcggcgc cgcccaccag gagatccggg cgctgcgcca 2581 cctcggtcag gcgcatttcg cagccgggcg gctcgactcc gcgggggaag atctggaggc 2641 ggccctttcg ctggccgagc gtacccacga cgtcgacgag aaagcccgga cggaaagcgt 2701 tctgacggac gtacggcggg cggtaggtgt cgcctcgacg acgcacgcct taccgggaca 2761 cacattcgaa ccgggcagta attaaacgcg caacaagtga atatcgttca attatgagat 2821 atgccgacgg tcatctacgg tcgcctccgg aatcaatcga tcaaggaggg atcccgtcac 2881 gtgagcacaa tgcgtcgact ggccgtcgtc accggtctcg ccactctcgc cattcttggc 2941 gtgaccgcgc caaatgcctc ggcggccgag cccgcctcga ccgcggcggt cggcacctac 3001 aggtgcatca tgatgtgacc ccctgagggt cgatcggcgc accgggggtg gcagcacacg 3061 ccgccacccc acccatcgga cacgagagga cggtgcgggg ttggagccga tatcggtggc 3121 gctgctggcg gcactggccg cgggagccgg cggcgaggcc ggccgagagg cctgggcgac 3181 actgagcgaa ctcgtccggc gcccgttccg gcgcgacggc agacatgacg gcagcggtga 3241 cggcagcggt ggcgacgacg gcgagggtga gggcgagggc aacaccgggg ccccggcggc 3301 gggttcggcg gaaccggagc tggtccggct ggccgcggac ccggacgacg cggcactggc 3361 ccgcgcgctg agcacggcac tggcggtgcg ggcggcgggg gacgcggact tccgggcggg 3421 tctcgcgcga tggcacgagc tggccggccc gctgcgcacc ggcgacgtgc acaacgagat 3481 cagcggcggc acgttcaccg gccccgttct ccagggccgc gacttctccg gcctctcctt 3541 cacgatcccg gccccaccga gcgtggaccc cggaaggaac accccgccca ccgccccgga 3601 ctgacgacga caccggccgg accggcaggt gtcacgccag ccgctccgcg aggtggtcgc 3661 cgacgcgcag ggcgttggcg atggcggtca gcgacgggtt gaccgccccg atgctcggga 3721 agaagctcgt gtcgacgaca tagaggttgt ccaggtcgtg ggccttgcag tggacgtcca 3781 gggcggagcc gccggggtcg tcgccgaagc ggaccgtgcc cgcctggtgc gcggtggcgc 3841 cgatgggcat gcccttgtgc agatagatgc tgtgcgacag gagatggtgt tcgttcatgc 3901 ccagatgacc gagcatgccc tggagtttgt gccgcaggcg gttcagtccg gcgacgttgt 3961 tcttctcgtc cagggccagg tggatgccgc cgtcgcggtc cagggtgacg cggttgccgg 4021 cggcgggcag gtcctctccg cagagccaga agtcgaccgc gtggtgggcg agcacctcga 4081 acggcatgtc gggggccatc gccccggccc agcggggcgc ttcgccgtgg atctgctcgg 4141 agtcggactt gccgagcatc tggatgccgc cgagggggta gtcccagtcg tcggctccca 4201 ggtaccagtc gtgcagtgcc agggtcttct ggaacctggt gtcgttcggc tccctggaga 4261 cggccatcag ggccaggttg ttgtgccgca tgtagttccg gcccaccacg tccgagctgt 4321 tggccagtcc ccgcggatgc cggtcgttgg ccgaacgcag cagcaggaca gcggaattga 4381 cggcgccaca ggcgaccacc acgaggtcgg cgcggaactc cacggtggcg gcgtccccgt 4441 cgcccggctc ccccaccctg gcgacgaccg aggtgacgct ccggccggtc gcgtccgtct 4501 ccagccgccg cacgtccgcg tgggtgacca tctcgacgtt ggggtgttcg agagcggggt 4561 cgacgcagat gacctgggcg tcggacttgg cgccgaccag acaggggaat ccgtcgaccc 4621 ggtcgcagcg gatgcaggcg ctggtgtggg tggcccggcc ccgctcgtcc tgggtgagat 4681 tcaccccgat cgggaggtgg aagggatgca gcccctgttt ctccaggtcg tggctgagct 4741 gctggatgcg cggctcgtgc tggaccggcg gatgggcgta ctgggcgctg gtggggccct 4801 cggtgggatc ctcgccgtgc cggccgtgga cgagatagag gtgttcggcc tgcgtgtagt 4861 acggctcgaa ctcctcgtag ctcaggggcc aggcgggcga cacaccgtcg tggtggcgga 4921 gttcgccgaa gtcctcgggg cgcagccgga agagcgcggc gccgtagaac ttggtgttgc 4981 ctcccacgta gtagttgacc tcgggcggga actccttccc gtccttgtcg taccagaact 5041 ccggcgcgcg gtacttcccc ttgacgaaga ccgctgtgga gtcccagttg tcccgttcac 5101 ggggaagata accgccgcgt tcgagaagga ggatccgctt tccggtgggt gccagtcgat 5161 gggcgagagt gccaccgccc gcacctgtcc cgatgatgat gacgtcgtag tactgcgcgt 5221 cggtcatgcc ggccaccgtc ctcggagcat gcgccggttc tgccgggtga atgggccgtc 5281 cgacccgacc accaacgtat ctccgagcga tgcctgcggc gagttgggcc ggtcgggtga 5341 accgggccgc cgggacgcga cgacgacccg tacgtgcgcg gaccgaccgg tgtcacagga 5401 tcgcgagggg attgacggga gagccggtgg cctcgggcag ccggagcggg gcgacgacga 5461 ggaggaacga ccagcggccc tcgctcgcgc agatcggcgc gaggtcctcg aaccgcagat 5521 agtccagcag gtgcagtccc atggcgtgga tgcccagcac atggaccggg aacgcgaccc 5581 cgcgggcggg actgggcgcg ctgtcgttgt tgccgtcacc gccgagtacg gccacctccc 5641 gctcggccag gaactccatg gccgtcggat ggagtccggc acgggcgccg gtcacgtccc 5701 aggggccgag ctcctcgcgg cggcggcggt gtccgacccg cacgagcagg atgtcgccgc 5761 ggccgacccg gacgccctgc cgtgcctcgg cggcggcgag gtcctcggcc cccacccgcg 5821 ctccgggttc gagccagggg acaccgtgca gccgggggat gtcgaggagg accccgcgtc 5881 cgacgacgcc gtcgcgggcg aggtcgacgg acagggcact cgcgccgtgc ggtgacagga 5941 cgtccgccgc cggtacgccc ccgtgcaggg tgccgtcgta gacgacgtgg cacagcgcgt 6001 cgaggtggct gttgacgtct ccgtgcacgt tcatcgcgaa gcggtcccgg gcgaactcca 6061 gtccgctcgt cccgggttcg ccgcccggcg gggcggtgag ccggtgttcg gccgggtcgg 6121 cgtcgtcagg tccgccgcgg gtgttcacgg gggcggcgag cgacaccgta cgccccgacc 6181 gcacctcgcc tacggcggcc agcacgaggt ccgcggtgat cgtgtccagg gcgccccggc 6241 gtccggcgcc gccgggggac gtgtcgcgca gctgccggta cagacgccgg aagtcggcct 6301 cgctcagatc gccgctcgtc cgcatgcccc caccctccgg caggtcccag gcccccgcac 6361 accgaggcgc cgggcccggg gccaccacgc cgagtcgccg ggcccggggc caccacgccg 6421 acgagcggac gaaccgttcc gcgggggtcc ggacggacat gagccgtgtc cgcgcggtgt 6481 gcccgccgga tcccaccgcc ggcgggccgt ccggcgccgg gtgggcgaac tccggcccgc 6541 gcgcgggccg cgggcgcacc gcgcgggagc cgtgcgggcg aggcccgtac caaggtgcag 6601 gcgaggcccg taccgaggtg cggccgtctc cgtccgatgc tgcaatgaag tccgaagaca 6661 ggggggccgc cgaacgccgg gacccagggg tgaagccgtg aacgatgaat tcgtcgaaat 6721 gggaccgatc gactatgtcg tcgtcgagtt ccccgggagc cgcatgaccg gggagggctt 6781 ccccctgctg gtcgatctgg tggaccgcgg cctcatccgg atcctcgatc tgctgttcgt 6841 ccggaaggag gaggacggat ccgtggtcgg cctggagatc gccgacctca ccggcgacgg 6901 ggttctggac ctggccgtgt tcgagggcgc ctcctccggc ctgctgggcc aggacgacat 6961 cgaggaggcc ggcggcgctc tgggagccgg caactccgcg gcgatcctgg tctacgagaa 7021 cctgtgggcc gcgcccttcg ccaccgccct gcgacgcggc ggcgcacaac tggtcgcctc 7081 cgggcggatc ccggtaccgg ccgtcctggc cgcgctggac gagacggacg acgtccggcc 7141 gccgagcacg tagagactcc ctcgcggtga cggaggacga ggtattcctg ggcctcggcc 7201 tgatcatcgt gctggccgtc ggctcccagg tgctggcgta ccgtctgcgc atccccgccc 7261 tgatcgtcct gctgcccgtc ggattcaccg cgggcgccct gaccgacgac ctcgaccccg 7321 agcggctcct gggcagcgcc ttctccccgc tggtctcgct cgccgtcgcg gtgatcctct 7381 acgacgccgg actcggcctg gacctgaggg gactcagagg ccacacccgc cgggtcgtgg 7441 tgcggctgat ctggttcggc gcgctggtca gcggcgcctc ggcggcgctg gtggccatgc 7501 cgttgctcgg gatgtcacag ggcgcggccg tgatgctcgg ggcgatcctc gtcgtgtccg 7561 ggccgacggt cgtcgggccg ctgctcacct tcgtccgccc cacggagcgc ctgcggcgga 7621 tcctcgtctg ggaggggtcg ctgatcgatc ccgtgggcgg catcctgggc gcgctggtct 7681 tccacaccgt cacggcgggc gggccgggcg gcttcggcag ccgggtcggc gccttcgccg 7741 tcagcacggc ggtgggggtg gcggggggcg tcgtcggagc ggtcgtcctg acggtggcgc 7801 tgcgcaggct ccggctcggc gaggtgctcg ccaccaccgt gcagctcgcc gcggtggtcg 7861 gcgtcgcggc cgcctgcgac gtcgtccggg acgacaccgg actgatcgcc gccgtcctga 7921 tggggctggc ggtggcgaac ctgcccggcg ggggtgtcac ggcccgcaga cccttcttcg 7981 agactctcgt gaacctggtc atcggactgc tgttcatctc catctcggcc accgtcagcc 8041 cccagtccct gcggcatgtg gtgctgccga cgctggggcc cgtggcggtc ctggtgttcg 8101 tggcccgccc cctggtggcg gccgtgtcgg catggggaac cgatctgacg cccggggaac 8161 ggggcttcct cgggtggatg gcgccacgcg ggatcgtggc agcggccacc gcctcgacgt 8221 tctcggcgac gctggtggac cagggcgtcc ggggcgcggc gaagatcctg ccggccacgt 8281 tcgtggtgat cgtcgccacc gtcacgctgt acgggctgag cgcggcggcg gtggccgggc 8341 ggctgggcgt ggtgcgctcg acgcgttccc ggccgctgct cgtgggcggg gatccctggg 8401 tggtggatct ggggcgggcc ctgcggtcgg ccgggctgga ggtggtgatg tgggcggggc 8461 gcgagacgga gcgggacagc atcagggccg ccgggatcga actcgccccg ggcgagctgt 8521 tcgccgcggc cacgggcgag ggcgccgaac tcgagggcct caccggggtc ctgctcctca 8581 ccggcgagga cgacttcaac gcgctggcgg ccacacgtct cgaaggcagc gtcgagtgca 8641 cggtccaccg gctgcggccg cccgcggaca gccagggcgt catcacgccc tacgcgggcg 8701 gcgaggtgct cttcgatccg gacctgaccg ggcccgaact ggcacgtcgt cacgcccgcg 8761 gtgcccgggt cgtggcgcat cgctgcgacg gcaccctgcc ggccggacac cggatgctgt 8821 tcctggtgcg cggtgacggc cggctcctcc cggtcacccg tgccgacggc ccggcgccgc 8881 ggccggggga cgtcgccgta ctcctgagcg cgtgatccgt cagcggcccg tggacctccc 8941 gaaggaggcg acggcggccc gcacccgggc gagcgcggcc ggcagagcgg tggtggcgtc 9001 cagggtcagg cccggctcgt ccgcctgcag tggctccagc gtcgcgaact gcgagtcgac 9061 cagccgggcg ggcatgaagt ggccggtgcg ccgggagacc cggtcccgtg cggtgtcccg 9121 gtccagggcg aggtagaggc accacagccg ggggcccgcg gccgcccgca gctcgtcgcg 9181 gtacgcccgc ttgagggccg agcaggcgac gaccagcccc tccccggcct cggcggagtg 9241 ccggacgcgg gcggcgaggg cccgcagcca gggttcgcgg tcggcgtcgt ccagggcgtg 9301 gccggcggtc atcttggcga tgttcgcggc gctgtggaag ccgtcgccct cgacgaacgt 9361 cactccgagc cgctcggcca acgccttgcc gacggtggtc ttcccggaac cggacacccc 9421 gaggaccagc acgatcggcg gcgcctgccc ggccccgcgc accggctccc cgcgcaccga 9481 ctccccgccg ccggtcacgg gctctcgggc tcccgtccgg ccgccgtccg ccgcaggtcc 9541 gcctcggtga ggggctggag ggccccggcg gtgttcagcc ggtagagcag gacgaggggc 9601 ggtccgacga gcaccacggc gatggccgtg accagcagca gccagcgcaa tgtcgtcgtc 9661 gcgccggccg cctcggacac ggtcagcgag gtggggatga gatagggccg ctgggccagc 9721 ccccacgcca cgacgacgag ggccacgctg ccgacggcgg tgatcctcgc ccatcccgtg 9781 gcggtgcggt acagcagcac ggcggtggcc agcgcgctga cgacggcgac caggacgagg 9841 gctagaccga tgccgctggt cagcccgtcg tggacgtagc gcgcgtcgtc gcgggtgacg 9901 acgaggccga cgcacgccag cacggcgagg acgccgaggc tgcaccaggc ccgcaggcgg 9961 aagtatccga ccaggtcggc ggcgtcgaag cggcgtgcgt cggcggtcag gaacaccgcc 10021 ccgaggaagg cggtcgcggc gacggtcagc agcccggcga tcacggacgt cccgttggac 10081 cacgcgtcgg ccgacgcctt cgtaccgggg gccacccggc ccgtggccag cccgccgacc 10141 gccgctccga ggaagaaggg cgtcagcagc gaggagacgg cgaagaccgc gccgtagacc 10201 ctgcgcccgg cgagccgctg cgtgggcttg cgcagcgcga acccggcgcc gcgcaggacg 10261 agtcccacgg ccgccagggc caacggcagc cacatggccg tgaagaccgt ctggaacagc 10321 accgggaagc cggtccacat gatgaccagg acgaagatga gccagacgtt gttcgtctcc 10381 cacaccggtt ccatggcgtg gtcgatgagc caccgggggc gcttgccgcg tgcggtgccg 10441 cccgcgagca ggtcccagaa tccggcgccg tagtccgtgc cgccggcaca cgcgtaggcg 10501 gccaccacgg ccagcagcac ccaggcgacg acgtcctcgg tcatgcgccg cccccgtccc 10561 tgccgccggt cgcggacacc ggccggggtc cgtagggggt gtccccctcc aggtcctcgg 10621 gggtggctgc cgcggcggcg ccctcgtcgg ccagccgcca tcgtccgctc atcctcagca 10681 ggacggtcag gaaggcgccg aacacgaggg cgtagagcac cacgacgagg ccgagcatcg 10741 tccacagggt cgaggcccgg gtgtccgtca ccgcctccgc gacccgcatg ttctggtaga 10801 cgatccaggg ctgccggccc acctcggtgg tgatccagcc gcactcgacg gtcagcagac 10861 aggcgccgcc ggccagtgcc gcgcaccgga agaaccacgg ggaccggggc aggtcacgcc 10921 ggcggagcca gcaccagccg taccagagcg cgagcaggac gagcaggctt ccgatggtca 10981 ccatgatgtc gaacgcccag tgcgcgatcg tggcctgggt cgccgtcgga cggtcggcgg 11041 ccgggaccga ggacagtccc gtgaccttgg tgtccgggct gaaaccggcg aggatcgagt 11101 ccagttgggg gatcctgatc ccgccggaga tcgtcccgtc ggaatgcagc cgcccgaaca 11161 tgtactccgg cacatgggtg tcggtcttcc agacgatctc ggtggccgcg aacttcaccg 11221 gctgcttgtg gaagacggac cgggcgatcg agtccccgag cacgaactgc acgggggtca 11281 ggatcgcggc gacggagaac ggcacggtga agccgagccg gtggtagcgg tcccggcggc 11341 cccgcagcca gccgaccgcg tacaccccgg cgatgacata gcccgcggtc agcaccactc 11401 cgaccacgaa gtgccagtac tccgggccga acatcggggt gaagatcgcc cttcgtacgt 11461 cgacgtccac gggggctccg gaggcgtcga gcgagaagcc gcgcggggtg ttcatccagg 11521 agttcgcggc cacgatgccg aacgccccca tcagtgcggc caggggcagg ggcaggccga 11581 gccagaagtg cgtccacggc ttgagccggc gccagccgta caggtagatg gcgatgagga 11641 tcgcctcgag gaagaacgcc caggcctcga ccccgaagcc gaggccgaag acatcacccc 11701 accggcccat catccccggc cacagcaggc cgagttcgaa ggagagcacc gtgccggtca 11761 cgatgccgat ggcgaactgg acggccatga ccgccgacca gcgccgcgcg agcagcaggg 11821 cgacggcgtc gcccttgcgc agcccgcggt agtgcatcag gagggtgatg gcgggcaggg 11881 ccacgccgaa gggcacgagc aggatgtggg agcccagggt gaaggccatc agctcccggg 11941 ccggcagcag ctgtgcgggg ccgtccgcca gaaagtggtc gatcgcgctg ttcacatggt 12001 cctcggtggc tcgtcccgga tggcgcagga gtggcgggtc tcagccgccc gtggcgaatc 12061 cggggaacag cgtcattccg ccgtcgacgt agatggtggt ccccaccacg tagtcgagaa 12121 ggtcggaggc cagcgtggcc accacgttcg cgatgtcgtc cgggtcgccg acgcggtggt 12181 aggggatgag ccggagaagg tcggcctcgg cctcgggggt ctcccaggca ctgcggttga 12241 tgggcgtgcg gatggctccc ggagcgacgg cgttcacccg gatccggtgc ggcgcgagct 12301 cctgggcgag ggtcgccatg agcatctgca ccccgccctt cgacgacgcg tagttcacat 12361 ggcccgccca ggggatgatc tggtggaccg aactcatgca gatgattttc ccggcggacc 12421 gggacacctc cggaacgaca cctcgccgca tgaattcctt ggccgcttca cgtgcgcaca 12481 ggaactgtcc ggtcagattc acgtccagta ccttgcgcca ctggtcgatg gtcatgtcgg 12541 tgaggggcgc atcccgctgg agccccgcat tggcgaccat gacgtcgatg gtgccgaact 12601 cctcgaccat ccgggagacc atgtcgacga cctggtcctc ctgcgacaca tcggcttcgt 12661 gcgcataggc gcggacgccg aaaccctcga tctcgcgtac cacttcctcc gcggcttccc 12721 gccccgcgac gtagttcacg accacatcgg ctcccacccg ccccaggccg atcgccgtgg 12781 cctttccgat gccggaattc gcgcccgtca ccagcgcctt ctgtcctttg aggagcaatg 12841 gggcaagggg ctggcgaccg tcattgccgc tggtttccac tcgtgtctcc ctgtgcgtgc 12901 cggcgcggac attcggcgga cgttcaaagg aatccgcccg acaacgaaaa cacgcgtgga 12961 tcggtacggc acggtggcgc gtcccccgtc agccgcccgg gtgcccgccc acgctgaacg 13021 gcccaatgcc cgccggccgg gtgacgcgga agggagcgga ccgctcgccc ggccggccgg 13081 gcggggtggt cgacgggctg gtcgacgagc cggtcggacc ggctgacggg accggctgac 13141 gggaccggct gatgggacgg gccggtcgga ccggacggtc ggaaagggct ggtcggacgg 13201 gccgtgagga cgggctactc ggtgcgggcg tcccggcccg ttccgatgca cagcgcccag 13261 atgacgaagg cgtccacggc gatcagcacg atggcccaga cgggttggta cggcagccac 13321 atgaaattgg cgatcatcga caggccggcg aggccgacgc cgacgacgcg tgcccacacc 13381 gcgccgccga acagagcggc acccgcgagc gcgaccagaa caccgaggac gagatggatc 13441 cagccccagc tcgtcagatt gaagttgtag gcgtaatcac gggtgacgac gaagacgtcg 13501 tcctgggcga tggcggcaat tccctggaat atcgccatca ccccgccgaa gatcatcatg 13561 accccggcga atccggtcca gccggacacc cacgctccgc cgccgcttgc ccttccctgc 13621 cggtgatgca ttccggtcgc ggtcatttcg ggctcctccc acacacatct cgccacggac 13681 aggtggccgt tcggtcgccc agatatcagc ttgccacgag aagcacaaac cggcagaaca 13741 ccggtattca cgcagttcag cgcgggggcc gacgtgcgag ggatatccgg cggtggtcca 13801 atgggggtat ccggtgcacc gaccgccgtg cgccggccgg agtatccgtc tcctccgcag 13861 gtctccggcg agaaaggaaa accgccgtgc caggtctcct ccgcggggtc gcccgcacag 13921 ccgtagtggc cggtaccgcg accgccgtgt ccaaccgcgt gtcacgccgc cagcaagggc 13981 gctgggccca gcaggactac caacaggccg cgccgccgca gccggcgccc gcgccgcagc 14041 cggccgccgc tcccccgccg gccgacatga gcagcaagat cgaccagctg aagcaactcg 14101 gagagctcaa ggcccagggc gtcctcaccg aggccgagtt cgaggagcag aagcgcagga 14161 tcctcgaatc ctgaaaggaa aggctgtacc ggagcagctc cggtacagcc tccgctccgc 14221 gacttcgcga agtcgggacg acaggatttg aacctgcgac cccttgaccc ccagtcaagt 14281 gcgctaccaa gctgcgccac gtcccgaggc gttgccgcgg cggtgagctg cgggaacgcg 14341 caggcagagc ctaccgtacg ggggtgggtg cggcggtcgg cgtctgacgg gcggccggcc 14401 ccggcagacg gtccgcgcgg cggaccggga ccagcagggc ggcgagggcg gcgcccaggc 14461 agagcaccgc gagcagggtg aatccgtggg tgtagccgga ctcgtagggc aggcccgacg 14521 gctggagccg gccggtgacc aggacgctgg tgacggcggc accgatggat ccgccgatgg 14581 tgcggatgtt ggcgttcatg ccggtggcgg cgcccgtctg cccggcgggg acgctgccga 14641 cgatcaggtt ggccatcgag gcgaaggcca ggccgatacc gaggccgaac acgcccgcca 14701 cgaaggcgac ctgccaccgc tcgtcgtgcc agagggcgag gaagcccagg gcgagcgcgc 14761 cgagcgcggc gccggccgtg agcagcgcct tggcgcccac gcggggctcg agacggccgc 14821 cgagcacacc ggagacgaac atcgccagca gcatcggcag catgaggagt ccggaggcgg 14881 tgacgctcgc gccgaagccg tacccggccg tgcccggcgt ctggacgaac ccgggcagga 14941 aggaccagat cgcgtacatg cccgcaccga acagcagggc ggcgaggttg gtggtccaca 15001 cggccgggag tcgcatgatg cgcaggtcga tcagcgggct gcgggagcgg gcctcggtgt 15061 acagccacag cgcgaacagc gccacggcga gggcgaacag gccgatcacc cgggccgagc 15121 cccagcccca gttgcccgcc tggctgagcg gcagcagcag ggcgaccagc cagccggaca 15181 gcagcacggc gccgagccaa ctgaccctgc cctccgcccg gtcgggcgac tcgggcacat 15241 agcgcagggc gatcagcgtg gcggccgcga cgatgccgac cgggatccag aacagccagc 15301 ggtagtccag cgcggagacg atcggaccgg ccgcgaccat gccgacgccg ccgcccgcgg 15361 cgatcacggc ggacaggttg ctgatgctgc cgggcacgcg ggagggggcg aactcgtccc 15421 tgatgatgcc gaaggagagc gggaacaggg cgccgccgat gccctggacg acccgggcga 15481 ggatcaggac gccgatgttc ggcgcgagcg cggcgagcag acagccggcc aggacggcga 15541 gcaggacccc gacgagggtg cgcttcttgc cgatcaggtc gccgacccgg ccgaggatcg 15601 gtgtgaagac ggacgcggac agcagatacg cggtcatcac ccaggtcgcg gtggactgcg 15661 aggtgtgcag cgcgtgctgc acggtcggca gggcgggcgc tatcagcgac tggagcatgg 15721 agaacacgcc cgcaccggtc gcgaggaccg cgaaggtgag gcgggtggac ttgcggggca 15781 tgacaagcct ctcggaaaga cccggaaaga ggagaagggg cctcggactg ttaaagtgga 15841 ggcacccctc cactgtaacg gaggcacccc tccgtttcaa ccgagtgccc gcccaggagg 15901 cagcagtgcc ggctcagccg ttccccatca gcgagatcgt cgcggcccag cgccccgtcc 15961 gtaaggacgc ggcccgcaac tacgacgcgc tgctcgccgc cgcccgccag gcgttcgccg 16021 agcacggctc cgaggcgtcg ctggaggaca tcgcccggcg cgcgggcgtc ggcatcggca 16081 cgctctaccg gaacttcccg acccgccggg cactgttcga gagcgtgtac gcggacgagg 16141 tcaacgcgct gtgccggtac gccgtggagt tcgccgacct ggagccgtgg gaggcgctca 16201 ccgcctggct cgagcggttc gccggttaca tggtcaccaa gcgggcggtg cgcgaggcgc 16261 tggagggcga gtcggagatc ttccaggcct gccgtgactc gatgtacgcg gcgggcggcc 16321 cactgttcga gcgggcccag cgggcggggg cggcccgcgc ggacatggac ttcggcgatc 16381 tgctgcggat ggtcgccggg atcaccgcga cggccttcgt ggacgacgcc cagcgcgacc 16441 gcgtcctggc catcgccctg gacggggtgc gcgccgggcg ccgatgaggg ggggtcagcc 16501 ggacagcggg taccgcgggg cgagcaggtc cgcgatccgc tcggtgatcg tctgggcggt 16561 gttgccctcg ggcgcgtccg ggcccaccgt cgtggacacc gcgatggaca gccgctggtg 16621 cggctcgtac gccatcacgg ccgcgtagcc gaagaaggac gggttctgca ccacccagcc 16681 gttcttgacg acgacgccga tgccgaagtg gaagtcctcg gtcatgggca gacagaccgt 16741 ggcgggacag ttcgcggtgg ggtgcccgag gccgacggtg cccgggtcca gctgggtgcg 16801 gaacgagcgc ttcgagagca gctcgcccga gccgatgccc tgcccggagc gggccaggtc 16861 acagatgtcc tgggtcagga cggcgcccgg cgcggtggtc caggaggggt tgaagtaggt 16921 ggactcctcg taggtgccgc gttcgtcgtc gtaggcgtgc agcacgggcg gcgggatgag 16981 cgcggtgtcg ttgttgcggg tgttgcgcag cttgaggggt ttcatgacgc gctgccgcag 17041 gagccggtcg agcggggtcc cggagatctt ctccagggcg cggccgagga ggacgaagtt 17101 ggcgtgcgag tagctccagt tggtgcccgg ccggtaccac agggggtgac tgagggagat 17161 cccgacgacc tcctcggggg tccagtgctg ccaggggtcg gcgtagagct tcttcaggaa 17221 caccgggtcg gtgacgtagt cgtgcaggcc cgacgtcgag tcgcccagca tccgcagggt 17281 gatcttgtcg ccgtgcggca ggtcgggcag ccagcgggag accgggtcgt cgaggcgcgc 17341 cttgtgctcc tcgacgagct ggagcagcac cgtgcccatg aaggcgatgc cgaccgagcc 17401 ggtccggaag tgcatggcgg gcgtggcggg cacgtccgtg agggactcgc cgaccgcgcc 17461 ggtgacgagc tcacgcccgc cgaccgtgac cttgaccagg gcggccttga gaccgagttc 17521 cttgcgggcg gcgcggacga gggcgaggac ctcgcgcgcc tggccccgcg gcttcggggt 17581 ggaggtgcag ggccggccct ggtgatcggg gacggcggtg gcggccacgg ccgccgtctg 17641 gaaggtggag gcgagaagag cggcggcgca cagcagcgcc gtacgggtac gcgtcatacg 17701 ggcactatgg gctgattgtc acatcggtca gggggtcaac actccgtacg ccctcacccc 17761 aggacccgta cggccctcgg cacgcctctc gcgacccgtc cggtcgaccc gttcggtcga 17821 cccgttcggt cgaggcgatc cgtcgacgcg atccgtcgag gccggtcgag gggatccgtc 17881 gaggcgcctg cccggaccac cgacgccgtc cggatgaccg acgcggtccg ggtcggcggc 17941 aggggggggg cggcgcgacg ccacacggcc cggcacccgc ggtttcgccc gggcggcggc 18001 ggccggggtg ggccggcgcg caccccttgc ccccggacgc ggggcgccag gccgctgccg 18061 ataccccgcg ggaaccggca gcccgacggc ccgcgccgcc cacgccgccc acgccgccca 18121 cgccgcccac gaagacgatc gacgccgagg agacccaccg gctcggccca gtcggcccgt 18181 cggtcccgtc ggtcccgtcg gtcccgtcgg tcccgtcgcc gagtggtggg cgccgagatg 18241 gacaccgtcg ccgactagct cgccgccgaa tctgccgtgc gccgcccgct ctccaccgac 18301 gtccaggaca ccggtagcgc cggtcgggcc ggtagcgccg gtagcaccgg ccggatgggc 18361 cgaggagcgc ggggtgtcgg gccggacggt cgcgcccttg cggggcacgt cgttcggact 18421 caccgccggg tccgtcgagt cggatgccgg acaggccctg ctcgatcaca ctctcggccc 18481 atgtcttcaa ctcttcggcg gattgggcta gatgctggag tacccgatcg cccgactgca 18541 cgcggaggcg cgcagccccg catccacgcc ggaacgagcg gggtcacgca gatggtcgtc 18601 gccggttccc cgggaccgtg agccgggggc ggggcgccgg ggcaaggaga cagggaggac 18661 ggtggggcat ggaggacttc tccgggcggc cgggagtggc gttcgtcgcg ggtggcacgg 18721 gcggcatcgg cgcggcggtc gtacggaccc tggcggcacg cggcagcgcg gtggtgttca 18781 cctaccgggt ccggcgggag gcggccgagg ccctcgccga cgaggccgaa gggctcgtgc 18841 ccctccccct ggacctgacc gacgagacgg cgacggcccg ggcgttgacc gcgaccgccg 18901 aggcgtacgg ctccctccac accctcgtgt acgccgccgg tccgcatgtg ccgatgcggc 18961 acctgagccg ggtgagcccg ggcgagtacc gggcccaact cgaggcggac gcgggggcgt 19021 tcttcaacct cgtccatccg gcgctgcccg tgctgcgccg gagccggggc agcatcgtcg 19081 cggtcaccac cgtcgccacc cggcgcttcc cggtgcgcga cgggctgtcc tcgggggcga 19141 agggggcggt cgaggcggtc gcccgcgccc tggccgccga ggaggggcgc tacggggtcc 19201 gcgtcaactg cgtcgcgccc ggcatgctca ccgacggcat cgcgggccgg ctgatcgagt 19261 cgggcgaact ggacgacgag gcactcgcgg tcgcccggcg gaacatcccg ctgcgccggt 19321 tcggggaggc ggcggacatc gcggaggcgg tgtccttcct cgcctcggac cgggccgggt 19381 tcatcacggg ccaggccctg ggggtcgacg gggggtacag cgtgtgaggc acccggcctc 19441 gcggagaggg caccggggtg gccacgcagt caagccggtc gacgacctcc cgaagaccgg 19501 ctcgactccg cagtcgttcc agtcttcggg gccgtccggt ccgcgtcaag gcccgtctca 19561 cgggtcgact cgggcaccgt cgtccacaca agcctttccc ggtcactcca ggaccgacac 19621 acagaatttt ccgtgccacc cggccgacgc cgggaatgtg cgtgtcgatt cggacaagcg 19681 gtccagagga acccatttcc tgcgttcgtt catgtttcta cagtgtgtga ggagggtgaa 19741 cgaggccggg cccgaaagga attcatccga tttcctacgc cctggccgtc cgcccgtgac 19801 tgaccgaatc attgcggctg gataccgccc gatcgttcga acgttgacca gtgagtaata 19861 agcgcactac ctttcaacgc gtttcgagca cgcgctttag aacggcgttc cgcggtggac 19921 cctgcccgcg ggaatccggt gagccgccat tgctgtcccg aaccccccac cgtgcagtct 19981 cacccttgat tcggagaatc atgacgtctg ctgtgcgttc cgaggacatg atcatcggca 20041 tcactccttt cggcgaaccc gatgccgggc tcgccctggc gatcgaccgg gccggcgggc 20101 tcggcgtact cgacctggga tccggtgacc gaagagcccg cgaggccctg tcccgcctgc 20161 gccgcgcctc cccgggcgcc ttcgcggtcc gggtcggcgc acactgccgg ctcacccccg 20221 ccgacctcga acccgacggc ccgcacacgc tggtcctcac tgcggacacc gacggggcgt 20281 cctggccggt cgaaggcctt tcggctcgct accgcgtgct ggtcgaggtc accgacctgg 20341 cgggcgcgcg cgacgcgtta cgtgccgggg cgcacggcct gatcgcccgc ggcgccgaga 20401 gcggggggcg tatcggtgaa ctgagcacct tcgtcctgct ccagcagctc ctcgccgcgc 20461 ccgaggtggc cgccccggtg tgggcgtgcg gcggcatcgg cccgcgcacc gccgccgccg 20521 cggtggccgg cggagcggca ggcgtcgtgc tggacagcca gctcgcgctg ctcgccgagt 20581 ccgcgctgcc cgaacccgcc gccgcggcac tgcgcaccct ggacggctcg gagaccgtcg 20641 tcctcgccgg acaccgggtc ctgctgcggc gcggccccga cgccccgcgg ctcccgctcg 20701 acgcgggacc gcaggcggtg gcggcgctgc tgggcgcgca ggatccgcgc ggacaactgc 20761 tcccggtggg ccaggacggc ttcctcgccg cgcggttcgc ggagcgctgg ggtgacgtgc 20821 ggcggaccct gcgggcggtg cgggacgcgg tcctggacgc cttacgcgac gacacggccg 20881 tacgggccct gcgggccggg tcaccgatga gccgggcgct cggcacccgg ctccccctcg 20941 cccaggggcc gatgacgagg gtgagcgacg gggctccgtt cgccgcggcg gtggcggccg 21001 acggggcact gcccttcctc gccctggcgc tggcggacgg cgcgcggacc cgggccatgc 21061 tcgccgagac ccgggacgcg gtggccggcc ggccctgggg ggtgggcgtg ctcggcttcg 21121 cgccggagga cgtgcgcgcc gcacagctgg aggccgtacg ggagctgcgg ccgacgcacg 21181 cgatcatcgc gggcggccgg ccgtcccagg cgcaggcgct ggagcgggac ggcatccgga 21241 ccttcctgca cgtgccgtcg ccgggactgc tgcgacagtt cctggaggcc ggggcccgcc 21301 ggttcgtgtt cgagggctcc gagtgcggtg gccacgtcgg accgcgcgcc agtttcgcgc 21361 tctgggaggc ccaactggcg gtcctggagg actggtcgca gggtcaccgg gccgaggagg 21421 tcgaggtgct cttcgcgggc ggcgtccacg acgaacggtc ggcggcgatg gtcgccgcgc 21481 tcgccgcgcc gctgaccgcg cgcggagcgg ccgtcggcct gctgatgggc accgcgtacc 21541 tgttcaccga agaggccgtc tcctgcggcg cgatccggcc gctcttccag cggcaggtca 21601 tggcggccga gcgcaccacg ctcctggagt cggcgccggg acacgccacc cggtgcgtgc 21661 cgagcccgtt cgccgccggg taccgcgacg aggaggcccg gctgcgggcc gagggcgccg 21721 gggaccgacg gatctgggag tccctggagc ggctcaacgt cggccggctg cgcatcgcca 21781 gcaagggcgt gacccgggac accgacggct ccctcacccc cgtcgacgag caacgccagc 21841 tcgccgaggg gatgttcatg gccggggcgg tggccgtgct gcgctcgacg accaccacgg 21901 tcgccgcgct gcacgagtcg gtgaccaccg gcgcgatcgg gcatctcgcc cggcgggcag 21961 ccgagtgggg ccgggaggag acggtccggg agccggccgc cccggccccg ctcgacatcg 22021 ccgtcgtcgg catggcgtgc atgttcccgc aggcacccga cctgcccacc ttctgggcga 22081 acgtggtcgg cggggtggac gcggtgggcg aggtcccggc cgaccgctgg gacccggccg 22141 tccaccacgg cgagtcgacc ccgtccaagt ggggcggctt cctgccccgc atccccttcg 22201 accccctgcg gtacggcatc ccgcccgcct cgctcggcag cgtcgagccg gtgcagctgc 22261 tgtccctgga ggcggcccgg cgcgccctgg aggacgccgg atacggggaa ggagagcggg 22321 cgttcgaccg ctcccgcacc tcggtggtgt tcggcgcgga ggcgggcagc gacctgtcga 22381 acgcggccac cctgagggcg gtcctgccct cgtactacgg cggcgtcccg gcgggtctgg 22441 acgaccagct cccgcagctc accgaggact ccttccccgg catgctcgcc aacgtgatct 22501 ccgggcggat cgccaaccgg ctcgacctcg gcggcgcgaa ctacaccgtc gacgccgcct 22561 gcgcctcctc gctggccgcg gtggacgtcg cctgcaagga actcgtcggc ggcacctccg 22621 acgtggtgct ctgcggcggc gccgacctgc acaacggcat caacgactac gtcctcttct 22681 cctccgtgca cgccctgtcg ccgaccggcc gctcccgcgc cttcgacggt tcggccgacg 22741 gcatcgcact cggcgagggc gtggcctgcg tcgtcctgaa gcggctcgcg gacgccgaac 22801 gcgacggcga ccgcatctac ggtgtgatca agggcctcgg ctcctccagc gacggccgct 22861 ccctcgggct caccgcgccc cggcccgagg gccagcgctc cgccctggaa cgcgcctacc 22921 gcaacgcggg ggtctccccg gccgacgtcg gtctcgtgga ggcgcacggc accgggacgg 22981 tggtgggcga ccgcaccgaa ctgcgcatcc tcggcgaggt gttcggcgag gccggggcgg 23041 cgccgggcag ctgcgcgatc ggctcggtca agtcgcagat cgggcacacc aagtgcgccg 23101 ccggactcgc cgggctgatc aagacggtgc tcgccctgca caccggtgtc cggccgccca 23161 cgctgcacgt cgaggccccc aacgccgcct gggaccggga gagcagcccc ttcgccttcc 23221 acgcacgcgc ccggccctgg gcggcgcctc ccgaggaacg cctcgccggg gtcagcgcgt 23281 tcggcttcgg cggcaccaac ttccatgtgg tgctgagcgc ccacgccggc ggcgtgccgc 23341 cggtacgggg cgcggacgcc tggccggccg aactgttcgt cttccgtgga cgggacgccg 23401 ccgcggccgg ccgcgcggcg gacgaactcc tcagggccgc ggaggctgag ggccggccgt 23461 ggcggctgcg ggacctggcg ctcggcgccg cccggcggtc cgacgcgagc ggggaaccgg 23521 cgcaggtcgc cgtcgtggcg acggacgtgg acgacctggt cggcaagttg cgacgggtgt 23581 cggccgatcc ggccgagcac gacccggcac gggggatcca ccgggccgga ccggacgacc 23641 ccggggacgc caaggtcgcc ttcctcttcc ccggccaggg gagccagcgc accggcatgc 23701 tcgcggacct gttcgtcacc ttccccgagc tgcggcccta tctggaactg ggacgcgccc 23761 acgccgacac cctgtacccg ccggccgcct tcgacgacgc ggaacacgac cgtcagcagg 23821 ccgcgctgac cgacacccgg gtggcccagc cggccctcgg cgtcgccggg ctcgccgcgc 23881 acgccgtgct caccgcggcc ggggtacggc cggacatggc ggcgggacac agctacggcg 23941 agctggtcgc cctctgcgcg gcgggggcgc tgagccccga gacactgctg gagctgagcg 24001 cggaacgggc gacggcgatc ctcgaagccg ccggtgcggc cggggctgtc gggtccaccg 24061 ggcccgccgg gtccaccgcg tccgccaggg caggcgggtc cgccggggca gccggtggtg 24121 atcccggcgc catggccgcc gtcgcggccg gtgccgacaa ggtggcgcgg gccctggagg 24181 cggtgcgggc gccggagtcc gtggtcgtcg ccaaccgcaa ctcgcccgag cagacggtga 24241 tctcgggccc cacggacgcc gtcgccgaca ccgtacggct gctgcgcgag gccggtgtcg 24301 gggccaagcg gatccccgtg gcctgcgcct tccacagccc gctggtcgcc ggtgccgccg 24361 accgcttcgc cgaggcactc gcggcccggc cggtgcacgc gcccgagttc ccggtgtggt 24421 ccaaccgcac ggccgccccc taccccgccg acgcggacgg ggtacgcacc gaactcgccg 24481 cccagatcgc cgccccggtc tccttcgccg agcagatcga ggcgatgtac gcggcgggcg 24541 cccgggtctt cgtcgaggcc ggccccgggt cggtgctgac ccgcctggtc ggacagatcc 24601 tcggcgaccg tccgcaccgc acggtggcgt gcgagccccg ccccggcggc ggactgcacg 24661 gctggctcga cgcgctggcc cggctcgccg tcgcgggcct gccggtacgc gccgggtggc 24721 tgctgcgcgg ccgggacgcg gtcgacgcgg tacggacccc cgtgccgaag cggcccggct 24781 ggacggtcga cgggcacctg gtccgcaccg ccgccggcgc cctccttccc ggtgcgctcg 24841 caccggcccg acgagtcgtg gaacccgaga ggaccgtggc gactgtgccg acgaaccccc 24901 cgcacggcgt cccgtccgac cgggacgcgc tggtctccga attcctgcgc accagccggg 24961 agatgatcgc cgcccaacgg gacgtgctgc tcacctactt cggggcgacc gcgggcgcgc 25021 cgcccgcggc gcccgctgcg cccgctgcgc ccgctgcggc ggtgccgcag gtgatccatg 25081 cggtgcccga actccccacg acgcaaccgg cggcggccgc cgcgacggcg gaaccggccg 25141 gggattccgc tccgccccgc gccaccgggc ccgtcgacgt ccagcaggtc gtcctggaga 25201 tcatcagcga gcgcaccggc taccccgtcg acatgatcga gcccgacctc gacctggagg 25261 ccgacctcag catcgactcc atcaagcggg ccgagatcgc gggcgagctg gcccgccgtc 25321 tgggtgccgg ggcgggcgcg gacctcgcgt cgatggacga cgacgagctg gaggagctgg 25381 cgaaggcgcg tacggccgcc gcggtgaccg actggctgac cgcccggctg ggcggaccgg 25441 acgcccccgt gcccaccgcc gggcacggca cggcgccggg ggaggcgacg gtggccgtgg 25501 cggtaccggc cacggagccc ggggcgcccg gacaggcggt cccaccggag gtgaccgggg 25561 aaccgccccg caggcacgtg ctgcggccgg taccgctcga cgccggaacc gacgccccgg 25621 ccgccccctc ggccgccccg tccgccgtcc cctccgccat gctctccgga acccgctgga 25681 tcctcctcgg ggaggcaccc gaggcggcgg cccggctggt gtcccacggg gccgacgtcg 25741 ccgtacgggc gcgggaccac gtcctggccg aggcggacgg gccggtggac ggcgtgctgt 25801 acctcggtgc cctcgacggc gcgggcgacg gccccgtcct gccggacgcg ttccccgtcc 25861 tgaaggcggc cctggcccgc ggcccgcgct ggctgctcgc cgtgcggacc gccgacggcg 25921 ggacacccga tccccgcacc gccgggctgc gcggcctgtt ccggacggtg gcacgggagt 25981 atccggagct ggtcgcccgg gtcgtcgacc tctgtgacgc ctcgccgtcc gccgtcgcgg 26041 acgccgtggt cgcggaggcc gtcgcgccgg accgcacccc ggtcgtcctg cggacggcgg 26101 ccggacggca cggcttcgag ctggtggagg cgccgctcgg cgcgctcggc agcacgggcg 26161 cgggacccgc cggggacggg gccgccgagg cggcggcgct cggactggac cgggactcgg 26221 tggtcctgct cacgggcggg gcgcggggca tcaccgcgca gttcgccgcc acgctcgccc 26281 gggccgcccg ctgccgtctg gagctgctcg gccgcacccc cgcgccggac ggtcccgagg 26341 ccgcggacac cgccgccgcc cgcaccccgg ccgagctgcg ggccgtgctc gccgcgcgcg 26401 gcggcgggaa gccgtcggag atcaaccgtg ccgccgaact cctgctggcc cagcgggaga 26461 tcaccgcgac cctcgccgaa ctcacggcgc tcggcggccg ggcccgctac cgctccgtcg 26521 acttccgtga acccggggcg gtgctccagg cggtgaagga gatccacgcc gagcacggcc 26581 ggctggacgg cgtggtgcac gcagccgggg tgatcgagga ccggctcgtc gcggagaaga 26641 gcgccgagtc cttccagcgc gtctacggca ccaaggcgac cggcgcggac gccttgctca 26701 ccgcgctgga ggacctgccc gccgcgcccg cgttcaccgt gctgttcggc tcgatctcgg 26761 ccgttctcgg caaccggggc caggtggact acgcggccgc caacgacgcg ctggagacgc 26821 tcggcgcggc cttcgccgcc cgtaccgggc accgtgcggt gaccgtgcac tgggggccgt 26881 gggcacccgc ggccgggcac gccggcatgg tgggggcgga actggcccgg gagtacgccc 26941 ggcgcggcat ccggctgatc gatcccgagg agggcaccgc ggcgctgctg cgggagctgg 27001 cctggggcga ggagtccgcc acggccgtcg tccacaccgc ctcgggctgg tgacggcggc 27061 catggccgcg cgtcaccggc cggtcgccgt cgtcggcatg gcggtcctgc tgccgggcgc 27121 cgccgacctg gacgcgtact ggcggaacct gcgggacggc gtggacgcga tcggcgaggt 27181 gcccgagggg cgctgggacg ccgcgtacta ccgtcccggc accgccgcgg aaccggccgt 27241 cgcggaccgg gtgtacgcgc gccggggcgg gttcgtggac gggctcgcgg aggtggaggt 27301 gacccggttc gggatcatgc cccactcggt ggccgggacc gagccggacc agctgatcgc 27361 cctgcacgtg gcctcggccg ccctggacga cgcgggcggc ccggaccggc tccccgaccg 27421 agggcgcgtc ggcgtcgtcc tcggccgggg cggctatctc ggtccaggcc tggtccggct 27481 cgaccaacgg gtccggacgg ccggccaact cgtccacacc ctcggtgagt tgctgccgga 27541 cctgacaacc gaccaactcg gccgggtacg ggcggcgttc accgagaggc tcggtccgga 27601 cagtcccgag tccgcgatcg gtctggtgcc caacctggcc gcctcccgga tcgccaaccg 27661 gctggacctg cgcggccccg cgtacaccgt ggacgcggcc tgcgcgtcct cgctcgtcgc 27721 cgtggaccag gcggtgggcg aactcggttc cgggcgctgc gacctgatgc tcgcgggcgg 27781 cgtgcaccac tgccacgaca tcacgctgtg gagcgtcttc tcccagctcc gcgccctctc 27841 ccccagccag cgcagccgcc ccttccaccg ggacgccgac ggcatcctga tcggcgaggg 27901 gacgggtgtc gtcgtgctca agcggctggc cgacgccgag cgcgacggcg accggatcta 27961 cgcggtgatc cggggcaccg gggtggccag cgacggccgg gccgcggggc tggtcaaccc 28021 cgatccgggc ggtcaggcac aggccgtccg gcaggcgtgg cgggccgccg ggctcgaccc 28081 ggccgagccc ggttcgatcg gtctgctgga ggcgcacggc accgcgaccc cggcgggcga 28141 cgaggccgaa ctggccaccc tcgccgaggt gttcggcccc ggcgacggtg aagcggtgct 28201 ggggtcggtc aagtcgatga tcgggcacac catgcccgcc gccggggtgg ccgggctcgt 28261 caaggccgcg ctcgccgtcc accacggcac gctgctcccg acgctgcact gcgacgaccc 28321 gcaccccgcc ctggcccgca cccggttccg caccctggag aaggcggccg actgggagac 28381 caccgagcgg cagcccgtgc gccgggccgc cgtcaacgcg ttcggattcg gcgggatcaa 28441 cgcgcacgtg gtgctggagg aggcgcccgg aacccgcgga tcccgcgcgt ccgggacccg 28501 cggatcccgc gcggccgccc cgccccgtcc ggccctggcg gtcaccgaac ccgagcaggt 28561 cctgctgctc gccgccgact cccccgcgcg tctcgccgcc cttctggacg ccgacgacgc 28621 cgccgtgcgg gccgccggac tcgcgccctc gcatccgcac ccggacgcgg gaccggcccg 28681 tctcggcatc gtcgacccga ccgccaagcg gctcgccctg gcccgccgcg cggtcggcaa 28741 gcggcgtgcc tggcacggcc gcagcgacgt ctggttccgg ccgagccccc tgctgggcgc 28801 cgaagggggt gggcccgcgt tcctgttccc gggcctggag ggcgacttcg ctccgcaggt 28861 cgacgacgtg gccgcccact tcggtctgcc cgccccgtcc gtcggcgggg accggaccgg 28921 tgacgtgggc cgtcacggct tcggtgtggt cgccgtcggc cggctgctcg acgccgcgct 28981 gcgccgcggc gggatcgtgc cgtccgcggt cgcaggacac agcgtgggcg agtggacggc 29041 gatggcgacg gccgggctgt actccgggga cgaggtcgac gcgttcatgg cggacttcga 29101 ccccgactcg gtatcggttc cggggctggc cttcggggcg atcggcgcgt ccgccgagcg 29161 ggtcctggcc gccctgcggg acggcggccc ggccacggcg ggcgtggtgc tctcccacga 29221 caacgcgccc ggccagtcga tggtgtgcgg gccgcaagcg gcggtggagg agttcgtacg 29281 ggccttccgc gcccagggtg tcctcagcca ggtgctgccg ttccggtcgg gcttccacac 29341 accgatgctg gaaccgcatc tcggcccgat caaggaggcc gccgaccggt tccggctccg 29401 tccgccgcac acccccctct ggtcggggac gaccgcagcg cccttccccg aggacgaggc 29461 ggggatacgg tcccttttcg tccgccatct gctggagccc gtccgcttcc ggcagctgac 29521 cgaggcgctg tacgcgtccg gacaccgggt gtacgtccag gtcggcccgg gtcagctcgg 29581 ctcgctggtc ggggacaccc tgggcggccg ggaccacctg gtcgtggccg ccaactcccc 29641 ccaccgcacg ggcctcgccc agctccgccg ggtggccacc gcgctgtgga cggcgggggc 29701 ggcggtggcg ccctccctgg aaccctccgt ggcgtcctcc cccgggccct ccccgacgtc 29761 cgccgcggcc gagcggacgg ctcggccgcc ggtgcggctg gatctgggcg gcgccctggt 29821 gtccctcgcg ccgcagcggc tcaccgccct gcgggccgag ctgcgcgccc cggtccgtgc 29881 ggcgggtccc gccggcccgt cgccgctgga cgccctggcc ggggactcgc cgatggccgc 29941 cgaactgtcc gccctgctgc acgagacggc ggacacggcg gccgccctca tgaccgcgag 30001 ggccggcgcc gtggcggccg cacggccgac cggcccgtgg cacggcagcg tccacgtctc 30061 ccccgacacc atgccctacc tgctggacca ctgcttcttc ccgcagcggc ccggctggcc 30121 cgaggtcgcc gaccggtggc cggtcgtccc ggcgacgacg atcgtgcggc acatcgtgga 30181 cgcggcggcg gacgcggcgc gggacgcggc ccccggcacg gtgccggtgg ccgtgcacgg 30241 cgcgcggttc gaggagtggc tcaccgccac ccccgccgtc gacgtgcccg tgaccgtgac 30301 ggccgaaggt tccggccggc tggccgtgtc cttcggtccc cgggcccgcg ccaccgtcga 30361 actggccgcc gcccacccac cgccgcccgc cccgtggccc gtcgaacccg tcaccgagcg 30421 tgccccggag cacaccgccg cccagctcta cgacgagcgc tggatgttcc acggcccggc 30481 gttccagggc gtcaccgagc tcaccgcgat cggcgaccgc cacatccgcg gggtgatcac 30541 caccccgtac gcgcccggcg ccctgctgga caacgtcggc cagatcctcg gctactggat 30601 catggcgacc catgccgaac ggaccgtcgt gttccccgtc gggatgcggg agatgcgctt 30661 ccacggaccg catccggcgc cggggaccga ggtggggtgc ctggtgcgga tcacctcgct 30721 caccgacgcc ttcctggagg ccgacgtgca gctgacggcc ggcggcacgg tctgggccga 30781 gctgtccggc tggcaggacc gccggttcga caacgacccc aggacccggc ccgtcgagcg 30841 cttccccgag cgccacaccc tgtccgagac ccgtccgggc ggctggcagc tgctgcacga 30901 gcggtggccg gacctggcgt cccgcgagct gatcatgcgc aactcgctgg gtggcgcgga 30961 gcgttcgcag tacgcgcagc acgcgccgcg cgggcgccgt cagtggctgc tgggccggat 31021 cgccgtgaag gacgcggtac ggcagtggct gtgggaccag ggcgagggcc cggtcttccc 31081 ggccgagctg cgggtccaca acgacgaggc cggacggccg tacgtcaccg gcgtgcacgg 31141 acgcgtcctg cccgcgctgg acgtctcgct ggcccactgc gcggaggcgg gcgtcgcgat 31201 cgtccggccg cacacgccgg gccccggccc gggaatcgac atcgaggagg tcaccgaccg 31261 caccccgcag accctcgccg ccgccctcgg cgaggacgaa ctacggctgc tgcgagacct 31321 gtcggccggc tccggcgact ccgaggcgct gtggttcacc cgcttctggg cggcgaagga 31381 ggccgtcgcc aaggcggagg gcaccggatt cgagggccgg ccgagggact tcaccgtgtt 31441 cgacgcgaca ccggccggcg accggctgac cgtcgcgggc cgcctcgaac gggcctggcc 31501 cgtgcactgc gcaccggccg ccaacccgcc ccggctgccc gaacgttcgt acgtggtggc 31561 ctggacgacg ggacacccga ccgcagagga gtacgacgcc cgatgacacc ccccaccccc 31621 cacacccccg tcaccgccga cgagcggtcc gtcctggccg atctcaccgg catgctcacg 31681 cggctcctgg aggacgagta cgggctcgac gacatcgaga tcgacctgca gaccaccttc 31741 aaccgggacc tggagctgga gagcatcgac ctcgtcaccc tggccggcct gctccaggag 31801 cggtacggcg accgggtcaa cttcgccgag ttcctggccg gcatggagtt cgacgagatc 31861 atcgaactga ccgtcggacg gctcgtcgag tacgtcgtga cgagcctgaa ggccgcggag 31921 gcgagctgag ccatggcgat ggtcgacacc ggcaccgtcc ggttgcacgt acagcggatc 31981 ggcccccggc agggccggcc ggccaccgcc accgtggtcc tggtgcacgg tctgctgacc 32041 gacagcctgg ccagctacta cttcaccgtc gccccggcgt tcgcggccgc cggcctcgat 32101 gtcgtcatgt acgacctgcg gggccacggc cgcagcgagc gccccaccgc gggctacgcg 32161 ctggacgaca acgtcgacga cctggaggca ctgctcgacc ggctcggggt gagcggtccg 32221 gtgcacctgg tcggcaactc ctacggcggc acgatcgcgt tcggctacgc ggcccggcac 32281 cccgagcggg cggccagcgt cagcctcgtc gagtccgaac cggccaccgc cgcctgggcg 32341 gtgaagctcg gcgggatcct ggaccgggtc gtgacccagc tcgcccggaa cgagtccgac 32401 gcgatcgcct ggatcaccgc gaaccgcggt cacaacacgg cccgcctggc caagggcgcg 32461 gcccggctcg cgcgggagac ctccctcggc cgggacatcc cggccagtcg ggtactgacg 32521 gacaatcaga tagcggcggt gcgctgcccg gtgctcggac tgtacggcgc cgactccgat 32581 ctggccgaac tggcgccctg gctccgggcg gtgctgccgg actgccgcac cgtggtgatc 32641 ccggggcatg agcactcggt cctcgtggag gcctcgggga cggtcggcgg gcacatcctg 32701 tccctcgtcg acgaggccgg tcgggtggcg gcggaggcga cggggtgagc cggttcctgt 32761 tcgtcgtacc gccgttggtg ggtcacctca acccggccgt aggcgtcgcc gccgaactca 32821 ccgcacgcgg ccaccgggtg gcgtgggcct gcgccgatcc ggagctggtc ggccggctgg 32881 cgggccccgg cgccgggacg gtgttcccct gcggcggcgc gccgccgggc gagcggcccg 32941 ccgacctgcg cggtccgcag gcgctgaagt tcctgtggga gtggtacctg ctgccgctcg 33001 ccgaggcgat ggcgccgggg gtgcgggcgg ccgtcgaggc gttccggccg gacgtcgtgg 33061 tcgccgacca gcaggccttc gccggcgcgc tggtcgcgga gcggctgggc ctgccgtggg 33121 cgacctcggc gaccacctcg gccgagttca cggatccgct ggccgggctg cccaaggtcg 33181 gggagtggct cgaccggcgc ctcgccggac tgcggtccgc gatcggcgat ccggcgggcg 33241 acgccgaccc ccgcttctcg ccacatctcg tcctcgcctt cagcacaccg gagttggcgg 33301 gcgaggcgca cgacggggtc cgctgggtgg gcccgtcggt cacggcccgg ccgtccgcag 33361 ccggcttccc ctgggagtgg ctcgacgacg gccgcgccac cgtgctggtc acgctcggca 33421 ccgcgaacac cgacgtcgga ggacgcttcc tcgaggtctg ccgggatgtg ctgcgggagc 33481 gggcggaccg ggtgcagggc gtgatcgtcg acccgggccg cacgctgcag ccgcggggcg 33541 aggacaagga cctgctgatc ctgccgtcgg tgcctcaact cgccctgctg gaaaggctgg 33601 agaaggcatc cggcgcggtt ctctgccatg ccgggcacaa caccgtgtgc gaggccctgt 33661 ggcacggcgt tcccctggtc gtggccccga tccgcgacga ccagccggtc gtggccgggc 33721 aggtcaccga cgcgggagcg ggcctgcggg tgcggttcgg ccgggtcacc gtgcgacagc 33781 tgggcgcggc gctcgactcc gtgctggacg aacccggata ccgcgccgcc gccgaccgga 33841 tccgtacggc gttccgcgcc gcgggcggtt cgtccaccgc cgccacccat ctcgaagacc 33901 tggcccggga gttcggatga ccgaggagaa caggaccgcc gagcggatcg ccgaggcgcg 33961 tcccgcctac cgggcggaca tcgccgccgg cctggaccgc ttcttcgagc cccgccgcac 34021 caactgcccg tggtgcggct cggcggcgct caccacccgg ctgcgcacca ccgacctgct 34081 ccagcacaag ccgggccgct tcgtcctgga ccgctgcgag agctgcgggc acaccttcca 34141 gaacccgcgg ctgaccgccg agggcctgga gttctactac cgggacttct acgacgggct 34201 gggcgagaag aagctcgggg acaccttcgg gggccggacg aagatgtacc gggggcgggc 34261 cgggtcgatg ctgccgcacg atcccgcgcc gaagacctgg ctggacgtcg gcaccgggca 34321 cggtcacttc tgcgcggccg cccgggaggt gctgcccggg acgacgttcg acgggctgga 34381 cttcaccgac ggcgtcgaac tcgccgagcg ggagggccgg gtggcgcacg gctaccgggg 34441 cgcgttcccg gagctggcgc ccgggctcgc cgcccgttac gacgtggtga gcatgttcca 34501 ctacctggag cacagcaccg accccgaccg ggaactgcgc gccgcgcacg agacggtgcg 34561 ccccggcggc catctcctca tcgaggtgcc ggaccccgag agccgctacg cgcggctgct 34621 gggccgctgg tggctgccct ggctccagcc gcagcatctg cacttcgtgc cggtggccaa 34681 tctgcgggaa cggctcacgc tgctgggctt cacggtactg gcggagcagc acgccgagcc 34741 gcacgacccg gtcgacctgc tggccgccgt ctggctggcg ctggaccacg cggcgccgcg 34801 cgacgacgcg ccgtggctgc ccgagccgcc gggcgcgctg cgccgcacgc tgcgcgccgc 34861 gatgctggtc gccgggatcc cggcactgat cgtgggcacc ctgctcgatc ggttcgcggt 34921 gcgtccgctc tcgcaccggc tcggtgtgtc caacgcgtac cggatcgtgg cccggcggga 34981 ctgagggacc ggtgcgcgcg cgggtccctc cgtgctagct tcgccccgtt cccttcaaca 35041 ggaatcctga tgatcgacgg cacggctcga cgaacggaac gcgcatgtcc ctcctggcca 35101 gaccggcggt ggccgccctc gccgccaaga cgatgcaggg cctcaccggg ctggcgagcc 35161 gccgatccgg tggccccggc ccgaccgccg gcgggcaggc ccgcttcccg gagtacccgc 35221 gcgtggtgcg tgagctgacg gtgccgacct ccgtcgcccc ggcccaggtc acggtgtacg 35281 agcccccggc cgggacggcg acgcccgcgc ccgtccacgt caacttccac ggcggcggct 35341 atgtcgtgtc gatgccggaa ctcgacgacg ggctctgccg gtggctggcc gccgaagcgg 35401 gggtggtcgt ggtcaacgtg aagtacgtcg tcgccccgca gcacccgttc ccggccccgc 35461 ccacgcaggc cttcgaggtg gtgcgctggg tcgccgagca cggcgcggag cacggctggg 35521 acggcgggcg gctcaccgtg ggcggacaga gcgcgggcgg cggactcacg gcggccgtgg 35581 cccgccaggc cctggaacag ggtggacccg cgatcgccct gcaggtgctg cactacccgc 35641 cgctggatct cgcgaccagc gcgaaggaca agaaggcggc tgtcgccaag cctctgttgc 35701 ggccctggat ggccgagatc ttcgacacct cgtacgtgcc ggatccgcgt gagcgcgccc 35761 accggttcgt ctcgcccgcc catgcctccg acaccgccga cctgacgggc atcgccccgg 35821 cgctggtcat cacggccgag tacgacctgc tcagggacga gggggtgcgc tacgcggagc 35881 ggctggacgc ggccggtgcc ctggtcgggc accacgacct cgccggggcc gaccacggct 35941 acgacaccaa ggacgacgag agggcccgga ccacctacgc gctgatcgcc cgccatcttc 36001 gacgggcgac cggcgccggt acgtcacggg cctcgtgagg ccgcgagggg gcgggaggtc 36061 gcgtccgccg caccggacgc cacccgggtg gtccgcaggc gtcgtccgcc gcaccggcgt 36121 gcccggccac ccgcccctcc ccgggtcgtc gccccgggca gccgcggtct actgtccggc 36181 ggcttccggc agggcgacgc ccagcttccc ggcgcgctcg gtcaggtcgc gccacacctt 36241 gggcgccacc gggacgccct tcttcccacg cccctcggcc acggcggcac tgcgctcgcc 36301 cgggtagaac acaccctgcg cgccgtccgc ggccggcagg cccttgaggg tgtccagcgt 36361 ggcgtccacg gacgcggcga aggcctccgc gcccccgaag gcggccgggt cgacggcgat 36421 gagcagggcg ttctggcggt gcttgcggcc ggccgggtcg tccgagtgga acgacgcgaa 36481 gatcggcgcc cccaccagca cgctggtcag cagctcgaag gcgagggaca tgccggagcc 36541 cttggccccg ccgagcggga gcggcatgac cgccttctcc gggtcggtgg tcggggtgcc 36601 gtcctcggtg gcggccgcgc cctcgggcag cggggtgccg ctcgccctcg cctgccggat 36661 cctgccgagc gcgacggtcg cggtcgccat gtccaggagc agcggcgcgt gcgccgacga 36721 ggagtcggtg ggcacggcga tggcgagcgg actggtggcg accgccgctc cccggacgcc 36781 ggtgtagccc atgttcggca tcccggcgac gaagccgatg ccgaccaggc cctgctcggc 36841 gatcctcgac acgtagtagc cgatcgcgcc ggtgtgcacc gtgcggcgca cgcccaccgc 36901 ggcgacgccg gtcgtccgcg ccctggtcac ggcctcgtcg gccgccgcgc tgagggccac 36961 cgggccgggg gcgcggtcgg cgtccaggac ggccgcggcc ggggtggtgg actcgacggt 37021 gatccgggcg tcggcgttgg cgacgccctt ctccagcagg tccagatagg cggggacccg 37081 ggcgatgccg tgcgagtcga cgccgcgcag cgcggcccag acgaacacgt cggcggtggt 37141 gcgggcgtgt tcggcgcgca gaccgccctt ctcgaggagg gccgcggaga aggtgcgcag 37201 gtcctcggcg ggcaccagga tcttcggggg tggggtgagg gtggacatgg tggcggtgcc 37261 tcctggttca gcgggtgacg aggacgtcga cgacggcggt ggtgccctcc gccacggcct 37321 tgagggcgcg ctcgagggcg ggtccgagcg cctgtgcggt gtcgacggtc tcggtgtgca 37381 tgccgaacgg ctcggcgaac cgggccagtc ggggcaggcg gtgcaggtcg gtgccgagcc 37441 attcgccggt ctgggcggcc gctccgtcgg gatagaacct gcggtggttg aggttcatcg 37501 acttatagac acggttgttg aacaccacga tgagcagcgg gagttcgtag gccctgctcg 37561 cgtcgtacga cgcgacgacc gggttgtagg tgaacgcgcc gtcaccgatg gtgaggacca 37621 ccggccggtc cttcgcggcg agtttgacgc cgagcgcgac cgcgatgccc tggccgaggc 37681 cgccctgtac gtagaagtac gagtcggggt cggccgtgcg caggtgccgc ttgaccacgc 37741 ggctgtgggt gatggtctcg tcgacgacga cgccgtccgc gccgtcgagc agttcgcgca 37801 gcgtggcggc gaccagtacc gggtcgacgc cctcggtctg ccgctgcgcc ccggccctgg 37861 cctcggcgtc ggcgatggcg gtctgctcgg cggcgtgccg ctcgtcctgc gcggtgcgcc 37921 gtacggcgac ggctgcctcg tcgagatcct tcgcccgctt ggcgagctgg cgcagcgtgt 37981 tggcgacgtt gccctccagg tacgcgtcgg cgaacaggac ctggtagacg acgtgcggac 38041 gctgcggcac ctcgtcgatg acgacgaccc gtgccttgga ggggcggcgc gacggcgggt 38101 agaacggcgc acggcagttg acgaggagga tgaggtccgc ctcgtccatc cacgggccga 38161 tgtcgctgcc ggcgtgcagc gggtgggtgc gcgggaagtt gccgcacacc gccgagtccg 38221 gttcgacgac cgggatgttc catgcctcgg cgaaggcgag gagtgcctcg aagccgcccg 38281 cctcccggcc ggcggtctcg gtgacgacga ccgggttcct cgcctcgcgg atcagccggg 38341 cgaccgcgtc ggcctcctcg ggcgagctgt gcgtggagcc cggcggcacg atgggcttgg 38401 cctcgcggcc gtcccagtcc tccaggagga tctccagcgg gacgttcagg tacgccgggc 38461 cggccggggc ccgccaggcc agctcggccg cccgcgtgac catggtgggc agcgtgtgga 38521 cgctggcggc ctcagtggac cacttggtga acggggccgc gaccccgtgc gggccgccca 38581 cgatggacag gttccggtac cactggccgc ccggatcctg cccggggccg tcaccgtagg 38641 tggtcgactc cgaggagctg accaccatcg ggacgccggc gagcagcgcc ccgtggacgg 38701 ccatcgaacc ctggagcagg ccgggcgccg cgtgcagcag caccccctgg ggccggcggc 38761 tgaccagtcc gtagccggtg gccatgccca cggcgacggt ctcgtgggtc aggtccaggt 38821 accgcgggca gggcagtccg tcccggtgac gccgggcgag ggactcccag acgggggccc 38881 actcggaccc ggacgagcag aacaggtagt cggcgccggc ggcgttgaag gcggtgacga 38941 gagcgtctcc gccgtcggcg cccggtgcgg tggtggtgtc ggtcatctcg cgtggttcct 39001 cagccctcga tcggccagtt caggacctcg gagataccgc ggcccatgat ccactccagc 39061 tcctcgggcg tgaagtccca gtgcttggtg aactgctcga tggtgtcggt gtaggtgatg 39121 ccgtggccca gcaggcgggt gatgtcggtg ccgtagaagc agcgctgcgg gcccatcttg 39181 tcgaccatct cgcgcacgta cttctggatg ttgttgttcg ggaacggctg cgtcgagtag 39241 ccgggcagcg ccgacacctt gacgtagatg ttcggatggg ccgcgaggtc cgcggtctcc 39301 gcgacccagt atccgatcgc gtcgtcgaca cagcgggcca tgatgcccat gtggtcgatg 39361 atgatcttca gctcggggtg cttggcggcg atctcgccga gctcacgctt ccagatcggg 39421 gcgtgcacca tggtggggat gccgagctcc gcggcgacgg gccagtacca gtcgttggtg 39481 ccgtcgatca tccagttgcg gtcctgcggc cggtggaagg tcagtcgcgt gcccttgatg 39541 tgcgggttct gcgcgaagtc cttcagcatg gccttgccct cttcgggctt gttctgcggg 39601 atgcgggcca tgatgccgaa gcggtccggg tgcgcctcgc aggcctccag ggcgtagtcg 39661 atgcggtcac cctcccagga cggcggcagg atcagcgcgc ggttcacgcc ggcctcgtcc 39721 atcagctcca gggcctcctc gtaggagaag gggtcctcgc ggtggccgtt gaggcggatc 39781 cgctcccggg cacccgggac ccaggggcgg tccggggtct cttccagcca gatgtggatc 39841 tgcgtgtcga cgacgaacat gtcccgtact tctttctctc ggcaaggcac gtggtgaggc 39901 ggtgcggagg gaacgctagg gggccggaaa ggccttgcgg agcccctggg agcgcaagct 39961 gttgttgcgt gaaagtgcgc tgttcgcaag gcactttcag attgcgcgag cggtcgccga 40021 aagcggtttc cgaacctgtc gcacaaccgg ttgcgcgaca ggcttcccgg cctgtcgcgc 40081 aaccggtttc acggtctgtt tctccgcagg caccggcaac ctctcgggca accggtttca 40141 cggcctgttt ctcggcaggc gtcggcgacc tcttgggcaa ccggtttcgc ggcctgtttc 40201 tcgacaggct ccggccgccg gtcccgcaac cggtttcgcg gcctgcttct cagctgttgc 40261 cggaagcgcg gtcgaaaacg gcttcgacga tgtgctcggc gatcgccatg gaggccgtcg 40321 cggccggcga gggcgcgttg cggacggcgg tgacccggcc cacccgatgg atacggaagt 40381 cgtccacgag ggtgccgtcc cggtcgaggg cctgggcgcg cacacccgca ccgccgcgca 40441 cgacgtcctg gacgccgacc gcggggacgt acagcttggc gtccttcatg aaggccgcag 40501 ccgagaacga cccgcggtac tccttgacgc cggtacgcca gtgccgggcc gccatcctcc 40561 agacgccggg ataggcggcg aggccgaaca ggtccttcgg ggagacccgg gtgcgggtgt 40621 acccctccct ggcgagggcc aggaccgcgt tggggccgac ctccaccgag ccgtcgacgc 40681 ggggggtgaa gtggacgccg aggaacgggt agcgggggtc cggcacgggg tagatcaggc 40741 cccgcaccag atccgtcttc tccggcctga gcagcatgta ctcgccccgg aacgggacga 40801 tccgcggctc ctgacggtcc tgtgcgaggc cggccacggt gtcggagtgc agccccgcgc 40861 acaggatcag ccggtccacc cgctcgcgcc gcggaccgga ggccacctcg atgccgccgg 40921 gcacctcggt gagggaggtg accgggaagc ccgtccgcac ctctcccccg gagccggcca 40981 cgtcctcggc gaaggcacgg gcgatggccg ggtagtcggt gatcgcggtg cgcggggagt 41041 acagggccgc gaccccgccg gcgttcggct cgatctcccg gatctcctcg cgggagacct 41101 tccgcagctc gggcacatgg ttgttcctgg cccggtcgta cagggcgttc atccggccga 41161 gctcgtcctc gcggaccgcc acgaccagct tgccgatctc gcggtacggc aactcgcggt 41221 cctggcagta cgcgcggagc agggccacgc cccgcaccgt cagctcggcc ttgagactgc 41281 cgggcgtgta gtagatgccg gcgtgcacga cgcccgagtt gtggccggtc tggtggagcg 41341 cgacctcccg ctccttctcg aagaccacga cccgggtgcc gggcctgctc agggcgatct 41401 cgcgggccgt ggccagaccc acgatgcctc cgccgacgat gccgatcgtc tcgtcagcca 41461 tcggcacctc ctctctgtgt agtcgctgct cacgatcgtc agccgccgaa gtgcacggcg 41521 accgtcttga cccgcgtgga gaagcgcagg acttcctctc cctgctcctt gtacgccgtg 41581 cccgagtcgt ggaacccgcc gaagggcagg tggacgtccc agccggtggt ggtggaattg 41641 accgcgacct gtccgcactc ggcctcgtcg gcgaagcggt gggcgctggc caggtcgcgg 41701 gtgaagaccg cggcggcgag gccgaacccg gagtcgttga ccgcctcgac ggccgcgtcg 41761 aagccgtcga ccgcgcgcag gacgaggacc ggcccgaaga cctcctcgcg ccagatcgcc 41821 gtctgcgggg tgacgtcccc gagcacggtc ggccgcacgt agcagccgtg ggctcgctcg 41881 ccctcggtgt ccgcgtggcc gccggtgagg acggtggcgc cctgctcgac ggccccggcc 41941 aggtgggcga ggacgctgtc gcgctgcctg gggctcgaca gcgggcacag ggtggtcgcc 42001 gggtcgctgc ccgggccgac cttcagcttc tcgacctcgg cgaccagcag ccgggtgaac 42061 tcctcgtaca ccggccgttc gacgacgacc cggctggtgg cggtgcagcg ctggcccgcc 42121 tgcccgaacg aagccgccac gacggctttc gcggcggcgg gcagatcggc gtccttcagc 42181 accaccgagg cattcttgcc gcccaactcg ccctggaaac gcacgttgcg gtcggcgaga 42241 cggcggcgga tgcggtttcc gaccgcgttg gagccggtga aggtgatgcc gacgatccgc 42301 ggatcgtcga ggagggcctc ctcgatctcg gcggtccggc cggtcaccac gttcagcacg 42361 cccgcgggca ggccggcttc gtgcagcgcg cgggcgaagt gcaggccgga gaccggggtc 42421 tcggtggccg gcttgaacac ggccgcgttg ccggtcgcga gcagcggggc gagcttgcgg 42481 gcgggtgtga tcagcgggtc gttccagggg ctgatcacca ggatcacgcc gatcggctcg 42541 cgctgggtgt gggtgcggtg gttcggccgt acgtcgtgca ggagggtgcc gtagccctgg 42601 cgggcgagac cggcgtagta ctccaggaag tcggcggact tgagggtctc tccggtcgcc 42661 tcggtcaggg tcttgccgtt ctccgccgtc acgtcggcgg cgatctcctc gacccgttcg 42721 cggatcagcc gggccgcgtc ggtgaagatc cgggcccgct cgaaggggct ggtgcgcttc 42781 cagacggcga acccgcgctc ggcgtggtcg aaggcacggg tgacgtcctt ggccgtgagg 42841 gcagggacgc gggcgacggg ggtacggacg tcggcggggt cgaggacgtc gatccattcg 42901 gcgctcgcca cccactcccc gcccacgagg gtttccaggg tacgcatgtc gggtcacttc 42961 ctttgtcggc cagggtgcgg actgtgacga cacaccacgt cagggcggtg ccgccagctc 43021 tgcggcagca ggcattgatt gcgccgcgcg cgggtggtcg cgggtctgat ccatgctgga 43081 atcggcaggc cggaggcctg acagcggtct ccgccgaccc atcgaggaga accggacatg 43141 ccctacgccg tcgtcgccca ctaccgctgc gcccccgccg acgagagcac cgtgcgcgcc 43201 gcgctcctgc gggtgcgcga gcacacccgc gccgagccgg cgaacgaggg gtacgaggtg 43261 cacgccgtcg aggggcagcc cggcggattc ctgttgtacg agcggtatgc cgaccgggcc 43321 ggattcgagg cgcacaaggc ggccgagcac ttccagcagc tgatcgtggc caccgtgtgg 43381 ccgctgctga cggaccggac ggtcaccttc gccgaggcac tgtagggcga ggcgccgcag 43441 ggcgaggcgc gcagggcgag gccccgtacg tcccgggccg ggcaactcct ctcagttgcc 43501 cggcccttgt ccaccgatgt cagaactcgt tgccccacac gtagcgggcg accgtctcca 43561 ccagcacgag tttcctgcgc tgctcctccg aggtcagcag cggccggctc gccacgtcgg 43621 cgaagccgcg ggacggcgac accgccgcgt cctcgaggtc cttgacctca ccggcggcgt 43681 cgatgcgggc catcaccgtg tcgatgtcct cgagttcggg cacggtcgcg tcgaccacgc 43741 ccaggcacac gtcccggtcc tccggcagcg cccggacgag gtcgagctcg gcgtcggtgc 43801 cctggtcgaa gggcaggatc cagcggtcgg ccggcaccgc gccgtacagc cgcccggcgc 43861 gcgcccggtc cacggtcccc ggggcggtga agccgggggc gaccccgatc cgtacgccct 43921 cgggccgtgt gtccagccgt accgcgaggg cctcgacggc gagggcgtcc tcgaaggaca 43981 gcgcgcccgg gtcggccggg tcggtcgcca actgacccag cagaagcggg ttgttgagct 44041 ggatcaggcg tacgcccttc gacaccagca gttcgatctc ggcctggatg atctccgcga 44101 gggcctcgcc cagttcgcgt gcggaggaca ccccgaggcc ggggcggtag gtggtcgcgg 44161 cgaggtaggc cggggagggc agcgacacct tcggcgcgat caccgtcagc gcggtgagcc 44221 ggtcggccca gtcggcgagc aacgggccgt tcgccttggg cagggactcg gcgacccgga 44281 cggcgagacc gtccgcgccg acctcgtcgg tacggcggaa accggtcacg gcgtcgagga 44341 cggcgccgcg gaagtcctcg cgggggaagt cgccgtcggt gacgacggtc gagcggagcc 44401 tgcgctggag gacgaccgcc tcctcgaccg ccttccgttc ggcggccgtc cgtgcctgcg 44461 ggtcgccggc cgcgcgggcg gcgaccagct cggcgggacg gaccaggctg ccgtggtggt 44521 cgatgcggta gttgaacgtg tccgccatgg gtcacgcgtc ctttccgggc ccggccggtc 44581 cgcccgcgac gccccaggcg gcgaactcca gctcgtagcc gagggaggcg agcacctcgt 44641 cggcgatggt ctggtcctcg cccgcggtgc cgccggcgat gccgaggccg ccgatgatct 44701 cgccgtcctt cttgatggtg acgctgccct cggcggccat gatcggcatg gccgcgcccg 44761 ggagctggga gagctgggcg aagaagacgg gctggctctc ctgccacttc ttcagcatcg 44821 tgccgggccg ctgcatgacg gccgcggtgt acgccttggc gcgggcgatg tccggggtga 44881 gggggcgggc cccgtccgcg cggcggacgg cgacggggaa gccgccggcg tccacgacgg 44941 cgacgctcac cgccttgccc acggcccggg cccgccgggt ggcggcctcg atgatctcct 45001 cggcggcggc cagggtcagg ctgctcatgt tgcttccttc ggtgcggtga gggtgcggcg 45061 cagacgggcg acggcctcgt tgtaggcccg gggcgtctcc cagtacatgg agtgcggggc 45121 gcccgggacg atctccaggt gcgatccggc gagcagttcg tgggcgcggg tcacggtctt 45181 gacgctcagc acggcgtcgt tctcgcccgc gaggaaggcg accttgacgc ccgaggcctc 45241 gatctcctcc agggaggggc cgttggtgtc gaggttgcgc aggtcctgca tcctggcgac 45301 gttgaaggtg cccatctgct ggaacaggaa cgtgagatcg gcgcggttcc gctggaaggc 45361 cttggtcaac agccggtcga tcaccgggag tttcaccgcc tcggcgcggt cggcggcggc 45421 cagttccctg agctcggggt ggctgatgcc gccgagggag tggccgagga cgacgcagga 45481 gacgcgtccg gggcgcagca ggccggcgcg cagggcggcg acggagccga tggactggcc 45541 gaccagcatg acgtcggtga ggtcctcctg gtcgaggacg gcgacgacgt caccggggaa 45601 gtcctggccg tcgaactcgg gcatggacga gtccgaattg ccgaagccgc gcaggtcgac 45661 ggtgacgacg gtgaactcgt cgcgcagggc ggcgacctgc tgccaccagg cggcgtggtg 45721 gccgccgctg ccgtgcacga acaggatcgc cggaccgctg ccgtggcgct cgtagtagag 45781 ggaggtgccg tcggagtcgg cgaggggcat gggatgtcac tcctcagcgg gggcgctcag 45841 tcgcggcgct tggcgtggtg gacgatctcg atcatggtgt ggtccgggtc gtggatgtag 45901 cagaacttcg actggttctc ggggcgctcg atggtccggg tgtgccggat gcccagctcg 45961 tcgaggtggg cgaggaagtc gtcccagtcg tcgacctcga cggcgaagtg atagggcgcc 46021 atgcgctcca tctcctcgac gggggtgaag tggaggtcga agttgccgcg ggtcatgagg 46081 acgacccggg tgttggactt gggcatgatc cgcttcatgc cgaagacctt cgtgtaccac 46141 tcggcggtgc ggtcggagtc ggtggtgggg aagttgacat ggtggatgta acggggttcc 46201 gcgctcatga ctggtgattc ccttcgaggt gaacggggtt ggacagcaca ccgatgccgc 46261 cgatctcgac ctccacggtg tccccgggct cgatcccgca ggtcgactcg gcgcccatcc 46321 acagcacgtc cccgggccgc atggtgatgt gccgggtgat ctcgacgatg aagtcgaacg 46381 ggtcgaagac catgtcgccg gtggggaacg aggcccgctc ctcgccgttg acccgcaagg 46441 tggttctctg cgccagggcg tcgacgtcgg tctcgatcca cggccccatc ggcttgaacg 46501 tgtcgctgtt cttgctgcgc cagaaggtgc ggtcctggtg ctgccaggtg cgggcgctga 46561 cgtcgttgcc gatcgtccag ccgaagaccg ccgtgcgggc ctcctcgtag gaggcgtgcc 46621 ggatcgtgcg gccgatgacg gccacgagtt cgggctcggc ctcgaagcgt ccctcgacct 46681 ccgcgggctt cacgatcggt gaacggtggc cggtgagagc gttgttggcg cggtagccga 46741 cctccgggcg gtccggcagg acggctgccg gattgccgag ccgggccgcg tgctcgatgt 46801 gccgggggta gttcaggccg accgcgtaga acacgggcgg gacgacgggc ggcagccagt 46861 cggccgtgtc gcgccgcacg gtcccgacga cttcgggatc cggccggccg gcgtcgcctt 46921 ccagggggga gccggagagc agctcgacgt cggtctcgcc cacccggccc caccgtgcac 46981 gtccgccgac cgagagtcgc gcgtacctca tggcgccagc tggtgggaga cgcgcttggt 47041 gaccaggtag gcgtccagtg cctcgggccc gccctcccgg ccgtacccgc tgtccttgac 47101 gccgccggag ggtgcctcgt ggacggagcc gccgcagtgg ttgagggaga ggatcccggc 47161 ctccagctcg gcggacagct tctcggcggt cgcggcggag tcggtgaagc cgtaggcggc 47221 gaggccgtac ggcagcgcgt tggcgagggc gacggcctcg tcgaggtcgc tgaacggcac 47281 gatcggcgcg atcggcccga acggctcctc gtgcagcagt tccgcgtcct cgggcacgtc 47341 ggtcaggacg gtcggcgcga agaaccagcc gggccggtcg ggccggtcgc cgccggtgag 47401 gatcttggcg ccgcgcgcga cggcgtcggc ggtgagccgt tccagggact tcagtcggcg 47461 ttcgttggcc agcgggccca tggtggtgcc gggttcgaga ccgtcgccga cgaccaccgc 47521 ctcggcggcc ttcacgaact cggcggtgaa ctccgtcacg aggctctcgt ggacgaggaa 47581 gcggctcggc gaggtgcaga cctgcccggc gttggcgaac ttcgcgcggg cggccttgcg 47641 ggcggcccgc accgggtcgg cgtccgcgca gacgatcacc ggggcatgtc cgccgagttc 47701 catcagcgac ggcttcatga cctggccggc ctgcgcggcc agcagctttc cgaccggcac 47761 cgagccggtg aaggcgacca gccggaccag cggggaggcg atcaggtggg cggagacctc 47821 ggcgggctcg ccgaagacga ggttcagcac gccggccggg agccccgcgt cggtgaagca 47881 gcgcaccagt tccatggcgg tcgccggggt ctcctcggag gccttgatga cgatcgagca 47941 gccggcggcg agcgcggcgg agatcttgcg catcgggccg cccgccggga agttccacgg 48001 gacgaaggcg gcgaccgggc cgatcggttc acggcggacg gtcaggagcg tgccgggctc 48061 ggccgggatg atccggccgt aggcgcggcg ggcgtcgtcg gcgtgccagc gcagcgtgcc 48121 ggccacccgg cgggcctcgc cggtcgcctc ggccagcggc ttgccctgct ccagggtcat 48181 gatccgtccg acctcggcgg cgcgctcggt gagcaggccg gcggcggcgt gcaggatgtc 48241 ggtgcgctcg gccacgggcg tcgcgcgcca caccctgaag cccgccgcgg cggcttcgag 48301 cgcgcggtcg aggtcggcgg ggtcggccag gggtacgtcc ccgatcacct cctcggtggc 48361 cgggttcacg atcggggcgg tacgtccggt gccgccctgg caccactcgc ccgcgatgtg 48421 gaggcggacg gcggggtagc cgtggtcggt ggtcatgggt gggtgccctc tcaggctgga 48481 gagtcgatgg ggccggggcg gttcaggagg cggtggtggc gtcctggtcg cggttggtgc 48541 gcagcgccca gatgtgatgc ggcggggtgg tctcgtggac gcgggtctcg taggtgtcgt 48601 cgacgcggtc catgtcggcc gcgtactcga cgcggccccc gcacggggcg tgcaggaagc 48661 ggaagacgtt cgagccgatg gtgtggcggc cgagccggcg ggcctcccgc cagcccttct 48721 cgatcatgtg gttgccgcct tcgacgacgt cgtcgaagcc gggcacctcg taggcgatgt 48781 ggttgacgcc cgcccggtcc gggcggtggc acagcagcat ggtgtgctgg tcgtcgtcgc 48841 ccggggcctg caggaagacg cccatcggct ccacgatgtc ggtcggccgg aagccgagga 48901 cgtcggtgta gaaggcgacg gcctcgtcct tgcccgcctt ggcgatgttc agcgccacat 48961 ggcacatgcg cagcgggtac gcgcgcgtga gcggctccag gggggtgttc caccggtgga 49021 cgccgcccgt cgcgttggcg ggacgggcgg cgacggtgac cggcttgggc cgggcgaggg 49081 tgaggcccac gccgaagccg ctgcggtcgg cggtgtgcag gacgccgtcg gcgctctcgc 49141 gcaccgggcg ccgccggccg gcggccgcgg ccagccgggt cagctccgcc gtggtgtcga 49201 cgccccagac gacctcgcgc agggtgggtc cgtcctccac cggcgggggc agcagggggc 49261 tcggggcggt gtcgaggtga agggtctgcc cggtgcgggt ctcgaacacg gcgtgttctt 49321 cggtccgctc caggaggaac aggccgaagt cgtcgaagaa ccggacgcat tcgtcgaggt 49381 cgtcgatgcc gtaggtgacc gattcgattc tctggattcc catggattcc tcgtttccgg 49441 gtcgcctggt gagcgtaggt ttggggtgcc ccgggcctca atggccccgg ctcaacccaa 49501 tgcgcaactc ttggttgcgt gtgccgtcag ggttaccgga tcgcgggaat cgggttctgc 49561 gagaaccatt cggagagaaa gtccaggaac acgctgatct tgcgcggggt gtcctgtccg 49621 gggccgtaga tggcgtacag cggacggtcg ggtacggcga gttccggcag cagcacctgc 49681 agtgcgccgg agacgaggtc gtcgtaggcc gggcgctgcg ggagcagggc gatgccgcgg 49741 ccgtgcacgg cggccttctg cagggccagg taggagttgg acgagaaggc gatgttgcgg 49801 atcttgtgca gggtgctcgc gtggccgtgg ccgatgcgcc agaccgggtc gttgacgtgc 49861 accaggcagt cgtggcccgc gatgtcgttg gggtgcgcga ggccgccccg gcgttcgatg 49921 tagtccgccg agccgcacag cacgaacggc agggaggaga tcttcttcag gcggacgctg 49981 gaatcgcgga ggtcgcgggt gtggaaagcg acgtcgaatc cgctgtccag gaaatcgtag 50041 gtgcggtcgg acatgccgcc gagttcgaat cggacctgaa tcttcggatg ggccgcggaa 50101 aaggcggcga tcgcgtcgcc caggtccagg ctgcctatcc atttcgggca gatgatgctg 50161 agggtgcctt cggcccggtc gtgcgagtcg gcgagtgccg cgtcctgcgc ttcgatctcc 50221 tcgaggatgc gggcggcgaa ttccgcgtac cgcagccccg gctcggtgag gctcaccgag 50281 cgggcggtgc ggttgaccag gcggaccccc acctgacgtt ccagttcggc cacgtgccgt 50341 gacaccagtg acccggagga gccgagtttc ttggcggctc cgttgaagct tccggcctga 50401 gcgacagtga cgaaactgtg catcagcagc aagcggtcca tgtttcctcc gattgcggct 50461 cccgcccgcg gcgtcgagaa cgggagcatt cctgcggctc gggacaaccg ggcgccggcc 50521 ggcaccgctt cccggtgggg ccctcacttc gggcagtact ggggtgcctc gctcaggttg 50581 tccttggtca ccaacagaag aggaatgttg gcaatcttgt caaccttttc cttgccaagg 50641 agcccgacgg cgttggtcac ggccgtctcg ccgatcgtct tggccgagtt cgcgacggtg 50701 gccgagaact cgccgttctt caccgcggtc aagccctcgt cggtcccgtt cacggtgacg 50761 atcttgacgt tcttcgcacc ggcggcgtcg aacgccttgc gcacggcgaa ggccatctcc 50821 tcgttggcga cgaacgcgta gtccaggccg ggattggcct ggatcatgtt ctccgccacg 50881 tcctgggcct tcgcgggatt gaacatgccc ggctggtcgg cgacgacctt cgccgtggcc 50941 ggaagggcgc ccttgaagcc gcccaccagc aggtccgagg ccgcgccggg agccccggcc 51001 acgatgccga cctgcacctc cttggtgccc gcgtcctggg cgatccagcc cgcgtcgagg 51061 ctgccgacct tcttgaggtc gacgacggcc gcgccgagga tgtcgccggc gtcgctggtg 51121 gacacggagg tcaggtagat cggtatgccc gaggccttcg ccttggcgat gtcgcccttg 51181 agcgcgtcga cgttgaccgt ctgcacgatc agggcgctca cgttgcggga gatcatgtcc 51241 tcgatgttgg acagctcggt cccggcgttc tggtgggagt tggccgtgta gaccttcgct 51301 cccgcggtct tcgcctggcc ctcgacggct ttctgcagac agctgtggaa gttggtgtcg 51361 ccaccgttga cgaagccgag ggagacgctg tcggtactgc cactgccgct gtcgccgttg 51421 ccgcagccgg tcagcacgag ggcggagccg gtgacggtgg cgaacagcgc cctgcgcgaa 51481 cgggcggaga gtctcatggg aaacgccttt caggacgggc atgaacgagg acgggcacgg 51541 acgagcggga aggtcagtga cgcgccgagc ccgagcgggc cttgtgcatc tcgttggcga 51601 cggccg //