LOCUS NZ_LMEQ01000022 5491 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_29, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000022 VERSION NZ_LMEQ01000022.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 5491) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 5491) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 5491 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000022.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers source 1..5491 /collection_date="2012" /country="Germany: Cologne" /db_xref="taxon:1736452" /host="Arabidopsis thaliana" /isolation_source="root" /lat_lon="50.958 N 6.856 E" /mol_type="genomic DNA" /organism="Streptomyces sp. Root1310" /strain="Root1310" /submitter_seqid="contig_29" region 1..5491 /candidate_cluster_numbers="1" /contig_edge="True" /product="T1PKS" /region_number="1" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /tool="antismash" cand_cluster 1..5491 /SMILES="C=CC(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="1" /tool="antismash" protocluster 1..5491 /aStool="rule-based-clusters" /category="PKS" /contig_edge="True" /core_location="[140:>5491](+)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" /tool="antismash" proto_core 141..>5491 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" gene 141..>5491 /locus_tag="ASD48_RS24150" /old_locus_tag="ASD48_41145" CDS 141..>5491 /NRPS_PKS="Domain: PKS_AT (119-404). E-value: 1.6e-100. Score: 328.2. Matches aSDomain: nrpspksdomains_ASD48_RS24150_PKS_AT.1" /NRPS_PKS="Domain: PKS_DH (471-635). E-value: 3.7e-68. Score: 221.0. Matches aSDomain: nrpspksdomains_ASD48_RS24150_PKS_DH.1" /NRPS_PKS="Domain: PKS_KR (951-1130). E-value: 4.9e-64. Score: 207.6. Matches aSDomain: nrpspksdomains_ASD48_RS24150_PKS_KR.1" /NRPS_PKS="Domain: PKS_PP (1225-1310). E-value: 4.7e-32. Score: 102.2. Matches aSDomain: nrpspksdomains_ASD48_RS24150_PKS_PP.1" /NRPS_PKS="Domain: PKS_KS(Modular-KS) (1333-1758). E-value: 1.8e-184. Score: 605.5. Matches aSDomain: nrpspksdomains_ASD48_RS24150_PKS_KS.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: mod_KS" /gene_functions="biosynthetic-additional (rule-based-clusters) adh_short" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic" /inference="COORDINATES: protein motif:HMM:NF012901.4" /locus_tag="ASD48_RS24150" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_41145" /product="type I polyketide synthase" /protein_id="WP_348983227.1" /sec_met_domain="PKS_AT (E-value: 2.7e-102, bitscore: 328.2, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="adh_short (E-value: 3.5e-68, bitscore: 215.1, seeds: 230, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 7.9e-17, bitscore: 47.9, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="mod_KS (E-value: 1.1e-233, bitscore: 761.7, seeds: 217, tool: rule-based-clusters)" /sec_met_domain="ketoacyl-synt (E-value: 1.5e-90, bitscore: 289.3, seeds: 77, tool: rule-based-clusters)" /transl_table=11 /translation="MSSFGISGTNAHVIVEQAPESAVGAVAESGVRVPVPVVPWVVSAR SAEGLAAQAERLARFVGERPALDPVDVGFSLVGSRSVWEHRAVVLGRDRDALLGGLREL PVRGVAAEGVRVAFAFSGQGAQRAGMGAELASXYPVFAEALAEVSGALGLDPEVFGDVD RLGRTEVTQAALFAFEVAVVRLLESFGVRPDVLIGHSIGEIAAAYVAGVFSLXDAAXLV GARGRLMQALPAGGVMVAVQAGEAEVVAALEGFXDRVAVAAVNGPSSVVVSGEAEAVEX VVARLGEVKSRRLRVSHAFHSPLMEPMLADFRZVVEQVTFQEPTVPVVSNVSGRFAEPG ELTXPDYWVRHVREAVRFGDGVRALAGEGVGVLVEVGPDSVLTALARESFDGGDGLRAV PLLRKDRPEPETLLTGVAQAFTHGVQVDWPALLPGGRRVELPTYAFQRRRYWLEEHSSW VGDADALGLASTEHPLLGAAVRLADGQGVVLTGRVSLRTHPWLADHAVAGTVLLPGTGF VELAIRAGDEVGCGRLEELTLEAPLVVPDRTGVSVQVRVGPEEASGRRQLTVHSLAAEG EEWVRHASGALTADSADTPAQTFDLTAWPPADAGPVELDGFYEALASSGYTYGPAFQGL RAAWRRGDEIFAEVGLPEQEIDGASAFGIHPALLDAALHATVATDGEDDGGQVRLPFAW TGVSLFATGATTVRVRLAYTGADTASLQLADPEGRPVASVDALVSRPVSKEQLRQSGGG EQDALYGVDWLPAATPAAPPAATATPRYDVLVCTSASQLVNGDVPELVRETTADVLRAL QGALADESPEPKRLIVVTRGAVSTGADDALRDPAHASVWGLVRSAQAEHPGRFVLVDVD VDVDVDVHEHVHEHVHEDEREGEDGGGGEGHGWGALLPAVLATGEPQIAVRQGALLAPR LVRTSAVVPDAGLENRAGDPDGTVLITGGTGSLGRVLARHLVVEQGMRRLVLAGRRGIE APGAAELVAELAQLGASVSAVACDVTDRDALDALLAGIPAEHPLTAVVHLAGVLDDGTI TALTPERLAAVLRPKVDAAVNLHLATRESDLRAFVLFSSVAGVFGGPGQGNYAAANAFL DALAQHRRAAGLPAVSLAWGLWEQDGGMTGRLEEGDRARIARSGLAPLSSAQGMALFDA APGRNRALLAPVRLDMAALRAQAASGTLPTLLRDLVRVPTRRTATTTEAGGPATALLRR LAGLTEPEQERALLDLVRTHAAGALGHPKPDAVGPQRGFLDMGFDSLMAVELRNRLNAA VDLRLPSTLIFDHPTPLALARYLRTEALGGRRTAGETLATTSVAADEPLAIIGMACRLP GDIDSPEALWRLVEEGRDVVADFPLDRGWKIGDLYDPDPDAPGKSYAREGAFLYDVADF DAELFGISPREALAMDPQQRLLLEASWEAFERAGLDVGGLRGSQVGVFAGAMPPDYVSR LNKVPEGVEGYTMTGSTSSVISGRVSYAFGLEGPAVTVDTACSSSLVALHLAGQALRGG ECTLALAGGVTVMSTPQEFVELSRQRGLARDGRCKSFSAAADGVGWGEGVAVLVLERLS DARRNGHEVLAVIRGSAVNQDGASSGLTAPNGPSQQRVIRAALANAGLSPSDVDVVEAH GTGTPLGDPIEAQALLATYGQERPESRPLWLGSLKSNIAHTQAAAGVAGVIKMVQAVRQ GVLPKTLHVDAPSPHIDWASGAVELLTEAREWPEVDRPRRAGVSSFGISGTNAHVIVEQ APESAVGAVAESGVRVPVPVVPWVVSAR" CDS_motif 492..542 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0001" /evalue="1.00E-04" /label="PKSI-AT-mM_m1" /locus_tag="ASD48_RS24150" /protein_end="134" /protein_start="117" /score="14.9" /tool="antismash" /translation="FAFSGQGAQRAGMGAEL" aSDomain 498..1352 /ASF="Malonyl-CoA specific" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS24150_PKS_AT.1" /evalue="1.60E-100" /label="ASD48_RS24150_PKS_AT.1" /locus_tag="ASD48_RS24150" /protein_end="404" /protein_start="119" /score="328.2" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="FSGQGAQRAGMGAELASXYPVFAEALAEVSGALGLDPEVFGDVDR LGRTEVTQAALFAFEVAVVRLLESFGVRPDVLIGHSIGEIAAAYVAGVFSLXDAAXLVG ARGRLMQALPAGGVMVAVQAGEAEVVAALEGFXDRVAVAAVNGPSSVVVSGEAEAVEXV VARLGEVKSRRLRVSHAFHSPLMEPMLADFRZVVEQVTFQEPTVPVVSNVSGRFAEPGE LTXPDYWVRHVREAVRFGDGVRALAGEGVGVLVEVGPDSVLTALARESFDGGDGLRAVP LLRK" aSModule 498..4070 /complete /domains="nrpspksdomains_ASD48_RS24150_PKS_AT.1" /domains="nrpspksdomains_ASD48_RS24150_PKS_DH.1" /domains="nrpspksdomains_ASD48_RS24150_PKS_KR.1" /domains="nrpspksdomains_ASD48_RS24150_PKS_PP.1" /locus_tags="ASD48_RS24150" /monomer_pairings="mal -> ccmal" /starter_module /tool="antismash" /type="pks" CDS_motif 708..830 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0002" /evalue="2.00E-22" /label="PKSI-AT-M_m3" /locus_tag="ASD48_RS24150" /protein_end="230" /protein_start="189" /score="71.5" /tool="antismash" /translation="GVRPDVLIGHSIGEIAAAYVAGVFSLXDAAXLVGARGRLMQ" CDS_motif 924..962 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0003" /evalue="4.80E-04" /label="PKSI-AT-M_m5" /locus_tag="ASD48_RS24150" /protein_end="274" /protein_start="261" /score="13.4" /tool="antismash" /translation="AAVNGPSSVVVSG" CDS_motif 1179..1214 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0004" /evalue="7.30E-05" /label="PKSI-AT-M_m8" /locus_tag="ASD48_RS24150" /protein_end="358" /protein_start="346" /score="16.1" /tool="antismash" /translation="YWVRHVREAVRF" aSDomain 1554..2045 /ASF="catalytic triad H,G,P found: False" /aSDomain="PKS_DH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS24150_PKS_DH.1" /evalue="3.70E-68" /label="ASD48_RS24150_PKS_DH.1" /locus_tag="ASD48_RS24150" /protein_end="635" /protein_start="471" /score="221.0" /tool="antismash" /translation="HPLLGAAVRLADGQGVVLTGRVSLRTHPWLADHAVAGTVLLPGTG FVELAIRAGDEVGCGRLEELTLEAPLVVPDRTGVSVQVRVGPEEASGRRQLTVHSLAAE GEEWVRHASGALTADSADTPAQTFDLTAWPPADAGPVELDGFYEALASSGYTYGPAFQG L" CDS_motif 1638..1712 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0005" /evalue="1.30E-10" /label="PKSI-DH_m2" /locus_tag="ASD48_RS24150" /protein_end="524" /protein_start="499" /score="33.7" /tool="antismash" /translation="WLADHAVAGTVLLPGTGFVELAIRA" aSDomain 2994..3530 /ASF="KR domain putatively catalyzing D-configuration product formation" /ASF="catalytic triad S,Y,N inconclusive" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS24150_PKS_KR.1" /evalue="4.90E-64" /label="ASD48_RS24150_PKS_KR.1" /locus_tag="ASD48_RS24150" /protein_end="1130" /protein_start="951" /score="207.6" /specificity="KR activity: active" /specificity="KR stereochemistry: B1" /tool="antismash" /translation="GTVLITGGTGSLGRVLARHLVVEQGMRRLVLAGRRGIEAPGAAEL VAELAQLGASVSAVACDVTDRDALDALLAGIPAEHPLTAVVHLAGVLDDGTITALTPER LAAVLRPKVDAAVNLHLATRESDLRAFVLFSSVAGVFGGPGQGNYAAANAFLDALAQHR RAAGLPAVSLAWGLWE" CDS_motif 2997..3098 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0006" /evalue="5.30E-10" /label="PKSI-KR_m1" /locus_tag="ASD48_RS24150" /protein_end="986" /protein_start="952" /score="31.9" /tool="antismash" /translation="TVLITGGTGSLGRVLARHLVVEQGMRRLVLAGRR" CDS_motif 3375..3485 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0007" /evalue="1.10E-22" /label="PKSI-KR_m4" /locus_tag="ASD48_RS24150" /protein_end="1115" /protein_start="1078" /score="72.6" /tool="antismash" /translation="LRAFVLFSSVAGVFGGPGQGNYAAANAFLDALAQHRR" aSDomain 3816..4070 /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS24150_PKS_PP.1" /evalue="4.70E-32" /label="ASD48_RS24150_PKS_PP.1" /locus_tag="ASD48_RS24150" /protein_end="1310" /protein_start="1225" /score="102.2" /tool="antismash" /translation="LAGLTEPEQERALLDLVRTHAAGALGHPKPDAVGPQRGFLDMGFD SLMAVELRNRLNAAVDLRLPSTLIFDHPTPLALARYLRTE" aSDomain 4140..5414 /ASF="found active site cysteine: True, scaffold matched GSSS: True" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS24150_PKS_KS.1" /domain_subtypes="Modular-KS" /evalue="1.80E-184" /label="ASD48_RS24150_PKS_KS.1" /locus_tag="ASD48_RS24150" /protein_end="1758" /protein_start="1333" /score="605.5" /tool="antismash" /translation="AIIGMACRLPGDIDSPEALWRLVEEGRDVVADFPLDRGWKIGDLY DPDPDAPGKSYAREGAFLYDVADFDAELFGISPREALAMDPQQRLLLEASWEAFERAGL DVGGLRGSQVGVFAGAMPPDYVSRLNKVPEGVEGYTMTGSTSSVISGRVSYAFGLEGPA VTVDTACSSSLVALHLAGQALRGGECTLALAGGVTVMSTPQEFVELSRQRGLARDGRCK SFSAAADGVGWGEGVAVLVLERLSDARRNGHEVLAVIRGSAVNQDGASSGLTAPNGPSQ QRVIRAALANAGLSPSDVDVVEAHGTGTPLGDPIEAQALLATYGQERPESRPLWLGSLK SNIAHTQAAAGVAGVIKMVQAVRQGVLPKTLHVDAPSPHIDWASGAVELLTEAREWPEV DRPRRAGVSSFGISGTNAHVIVEQAP" CDS_motif 4620..4667 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0008" /evalue="8.80E-07" /label="PKSI-KS_m3" /locus_tag="ASD48_RS24150" /protein_end="1509" /protein_start="1493" /score="20.8" /tool="antismash" /translation="GPAVTVDTACSSSLVA" CDS_motif 5043..5087 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ASD48_RS24150_0009" /evalue="4.00E-04" /label="PKSI-KS_m5" /locus_tag="ASD48_RS24150" /protein_end="1649" /protein_start="1634" /score="12.6" /tool="antismash" /translation="VEAHGTGTPLGDPIE" ORIGIN 1 ccgtgagcgc ggagctatcc ccggcgggct ggtgtgtcgt cgttcgggat cagcgggacg 61 aacgcgcacg tgatcgtgga gcaggcgccc gagtccgctg tcggggcggt tgccgagtcg 121 ggtgtccccg gcgggctggt gtgtcgtcgt tcgggatcag cgggacgaac gcgcacgtga 181 tcgtggagca ggcgcccgag tccgctgtcg gggcggttgc cgagtcgggt gtccgtgtcc 241 cggttccggt ggtgccgtgg gtggtgtcgg cgcgcagtgc ggaagggctg gccgcccagg 301 ccgagcggct cgcccgattc gtcggcgagc gccccgcgtt ggacccggtg gatgtggggt 361 tctcgctggt cgggtcgcgn tcggtgtggg agcaccgggc ggtggtgctg gggcgcgatc 421 gggacgcatt gctnggtggg ttgcgggagt tgccggtgcg gggtgtggcc gctgagggcg 481 tgcgggtggc gttcgccttc tcggggcagg gggcgcagcg ggccggaatg ggtgccgaac 541 ttgcctccgn ctanccggtg ttcgcggagg ctttggcgga ggtctcgggt gccttgggtc 601 tggatcccga ggtgttcggg gatgtggatc ggttgggncg gacggaggtg acgcaggctg 661 cgctgttngc ntttgaggtg gcggtggtgc ggttgttgga gagtttcggg gtgcggcctg 721 atgtgttgat cgggcattcg atcggggaga tcgcggcngc gtatgtggcg ggggtgttct 781 cgctggngga tgcggcnnnn ntggtggggg cgcggggtcg gttgatgcag gcgttgccgg 841 ctggtggcgt gatggtngcg gtgcaggcgg gtgaggcgga ggtcgttgcc gctcttgagg 901 gtttcgncga tcgtgtggcg gttgccgcgg tcaatggtcc gtcgtcggtg gtggtctccg 961 gtgaggcgga ggctgtggag cnggtggtcg cgcggctggg ggaggtgaag tcccgtcgtc 1021 tgcgggtcag tcacgcgttc cattcgccgt tgatggancc gatgctggcg gacttccggn 1081 aggtcgtcga gcaggtcacc ttncaggagc caactgtccc cgtcgtctcc aatgtgtccg 1141 gtcgattcgc ggagccgggt gagctgacca ngcccgacta ctgggttcgg catgtgcgcg 1201 aggcggtccg tttcggtgac ggtgtccgcg cgctggccgg tgagggcgtg ggtgtgctgg 1261 tggaggtcgg tccggacagt gtcctgaccg cgctggcccg ggagtccttc gacggcgggg 1321 acggtctgcg ggcggttccg ctgctgcgca aggaccgtcc cgagccggag accctgctga 1381 ccggggtggc gcaggcgttc acgcacggcg tccaggtcga ctggcccgca ctcctccccg 1441 gcggccgccg tgtggaactg cccacctacg ccttccagcg ccggcgctac tggctggagg 1501 aacacagctc ctgggtgggc gatgcggacg cgctcgggct ggcgtccacc gagcatccac 1561 tgctgggggc ggcggtgcgg ctggccgacg gacagggtgt ggtgctgacg ggtcgggtgt 1621 cgctgcgtac acatccgtgg ttggcggacc atgcggtggc cgggacggtg ctgctgccgg 1681 gcacgggttt cgtggagctg gcgatccggg ccggggacga ggtgggctgc ggacgcctgg 1741 aggaactcac tctcgaagca ccgctcgtcg ttcccgacag gacgggtgtg tcggtgcagg 1801 tccgcgtcgg gcccgaagag gcttccgggc gcaggcagtt gacggttcac tcgctggcag 1861 ccgagggcga ggagtgggtg cggcacgcca gcggtgcgct cacggccgac tcggccgata 1921 ctccggcgca gacgttcgac ctgacggcct ggccccccgc cgacgccggc cccgtcgaac 1981 tcgacggctt ctacgaagcg ctcgcctcct cgggctacac ctacggcccc gcgttccagg 2041 gccttcgtgc cgcctggcgg cgcggcgacg agatcttcgc cgaggtgggc ctgcccgagc 2101 aggagatcga cggcgcgtcc gccttcggaa tccatccggc tctgctggac gccgctctgc 2161 acgcgacggt ggcgaccgac ggagaggatg acggcggtca ggttcggctg ccgttcgcct 2221 ggaccggggt ctcactgttc gccacgggtg ccacgaccgt tcgcgtacgg ctggcgtaca 2281 ccggcgccga caccgccagc cttcagttgg cggacccgga gggccgtccg gtcgcgtccg 2341 tcgacgctct ggtctcccgc ccggtgtcca aggaacagct gaggcagtcg ggaggcggcg 2401 agcaggacgc gctgtacggc gtggactggt tgcccgccgc gacgcccgct gcgccgccgg 2461 ccgcgacggc cacccccagg tacgacgtgc tggtgtgcac gtcggcgtcg cagctcgtga 2521 acggggacgt tccggagctc gtgcgggaga ccacggccga cgtactgcgg gccctgcaag 2581 gggcgttggc cgatgagtcg ccggagccga aacgactgat cgtggtcacc cggggcgcgg 2641 tgagcaccgg ggcggacgac gccctgcgtg atcctgcgca cgcgtcggtg tgggggctgg 2701 tgcgttccgc gcaggcggag caccccggcc ggttcgtcct ggtcgatgtc gatgtcgacg 2761 tcgatgttga cgtccacgag cacgtccacg agcacgtcca cgaggacgag cgcgaaggcg 2821 aggacggagg cggaggcgaa ggccacgggt ggggtgcact cctgcccgcc gtgttggcga 2881 ccggcgaacc ccagatcgcg gtgcgccagg gagccctgct cgcaccgcgg ctggtgcgta 2941 cgtcggccgt cgtccccgat gccggtctcg agaaccgtgc cggggatccc gacggcacgg 3001 ttctgatcac cggcgggacg ggttcgctgg gtcgagtgct cgcgcggcac ctggtggtcg 3061 agcaggggat gcgccggctc gtgctggccg gtcggcgtgg tatcgaggcg cccggcgcgg 3121 ccgaactggt ggcagaactg gcacagttgg gggcgtcggt atcggccgtc gcctgcgacg 3181 tgaccgatcg ggacgctctg gacgcactgc tggcagggat accggcggag catccgctga 3241 cggccgtcgt ccacctggcg ggagtcctgg acgacgggac gatcacggcg ttgaccccgg 3301 agcggctggc cgccgtactg cggccgaagg tcgacgcggc tgtcaacctg cacctggcca 3361 cacgggagtc ggaccttcgt gccttcgtcc tcttctcctc cgtggcgggc gtcttcggcg 3421 gaccggggca aggcaactac gcggccgcca acgcgttcct cgacgcgctc gcccagcacc 3481 ggcgggcggc cggtctgcct gccgtgtccc tggcctgggg cctgtgggag caggacggcg 3541 ggatgacggg gcgcctggag gagggcgacc gggcacgcat cgcgcggtcc ggcctcgcac 3601 ctctgtcctc ggcacagggg atggccctgt tcgacgcggc gcccggccgg aacagggcac 3661 tgctggcgcc cgtccgcctg gacatggccg cgctccgggc gcaggcggcc tcgggaaccc 3721 tgccgacact gcttcgcgac ctggtacgcg tccccacccg acgcaccgcg accaccaccg 3781 aggccggcgg gccggccacc gctctgctgc ggaggctggc cggcctcacc gaacccgagc 3841 aggaacgcgc gctcctggac ctcgtacgca cccacgccgc cggagcgctc ggccacccga 3901 agccggacgc ggtcggaccg cagcgcggtt ttctcgacat gggcttcgac tccctgatgg 3961 cggtggaact ccgcaaccgg ctcaacgccg ccgtcgacct ccgcctgccc tccaccctga 4021 tcttcgatca cccgaccccg ctcgcgctcg cccgttacct gcggaccgag gcgctcggag 4081 gccggcggac ggcgggggag acccttgcga ccacgtccgt cgcggccgac gagcccctgg 4141 cgatcatcgg catggcctgc cgcctgcccg gtgacatcga ctcgcccgag gcgctgtggc 4201 ggctggtcga agaggggcgg gacgtcgtcg cggacttccc gctggaccgc ggctggaaga 4261 tcggggacct gtacgacccc gaccccgacg cacccggcaa gagctacgcg cgggaaggcg 4321 cgttcctcta cgacgtcgcc gacttcgacg ccgaactgtt cggcatctcg ccccgcgagg 4381 cgctggccat ggatccgcag cagcgcctgc ttctggaggc gtcctgggag gccttcgagc 4441 gagccggcct cgatgtgggc gggctgcgcg gaagccaggt cggcgtgttc gccggagcga 4501 tgccaccgga ctacgtctcg cggctcaaca aggtgcccga aggcgtcgag ggctacacca 4561 tgaccggcag cacctcgagc gtcatctccg gccgggtctc gtacgcgttc ggtctcgagg 4621 ggcccgcggt gacggtggac acggcgtgct cgtcctcgct ggtggcactg cacctggccg 4681 gtcaggccct gcgcggcggc gaatgcacgc tcgccctcgc gggcggcgtt acggtgatgt 4741 ccactcccca ggagttcgtc gaactgagcc gccagcgcgg actggcccgc gacggccgct 4801 gcaagtcctt ctccgccgcc gccgacggtg tgggctgggg cgaaggcgtc gccgtcctcg 4861 tcctggagcg gctgtcggac gcgcggcgca acgggcacga ggtactggcg gtgatccggg 4921 gcagcgccgt gaaccaggac ggcgcgagca gcggcctgac ggcgccgaac ggtccctccc 4981 aacagcgcgt gatccgtgcc gcgttggcca acgccggtct gtccccgtcg gacgtcgacg 5041 tcgtcgaggc ccatggcacc gggacgccgc tcggggatcc gatcgaggcg caggcgttgc 5101 tggcgacata cgggcaggag cggccggaaa gccgacccct gtggctgggg tcgttgaagt 5161 cgaacatcgc gcacacgcag gcggcggcgg gtgtcgccgg agtgatcaag atggtccagg 5221 ccgtgcgaca gggggtgttg ccgaagacgc tgcacgtgga tgccccctcg ccacacatcg 5281 actgggcctc cggtgccgtc gagctgttga cggaggcgcg ggagtggccg gaggtcgatc 5341 gtccccggcg ggctggtgtg tcgtcgttcg ggatcagcgg gacgaacgcg cacgtgatcg 5401 tggagcaggc gcccgagtcc gctgtcgggg cggttgccga gtcgggtgtc cgtgtcccgg 5461 ttccggtggt gccgtgggtg gtgtcggcgc g //