LOCUS       NZ_LMEQ01000018        22802 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root1310 contig_25, whole genome shotgun sequence.
ACCESSION   NZ_LMEQ01000018
VERSION     NZ_LMEQ01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1310
  ORGANISM  Streptomyces sp. Root1310
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 22802)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 22802)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1310
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426425.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 02:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,470
            CDSs (total)                      :: 8,385
            Genes (coding)                    :: 8,123
            CDSs (with protein)               :: 8,123
            Genes (RNA)                       :: 85
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 262
            CDSs (without protein)            :: 262
            Pseudo Genes (ambiguous residues) :: 0 of 262
            Pseudo Genes (frameshifted)       :: 98 of 262
            Pseudo Genes (incomplete)         :: 219 of 262
            Pseudo Genes (internal stop)      :: 20 of 262
            Pseudo Genes (multiple problems)  :: 64 of 262
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 22802
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEQ01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22802
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..22802
                     /SMILES="CC(=O)CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22802
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6103:14797](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(6104..14797)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            complement(<1..>3477)
                     /locus_tag="ASD48_RS23980"
                     /old_locus_tag="ASD48_40975"
                     /pseudo=""
     CDS             complement(<1..3477)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981855.1"
                     /locus_tag="ASD48_RS23980"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_40975"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYEGLTESGYGYGPVFQGLRAAWRRGEELFAEVALPAEEAEAAAG
                     FGIHPALLDAALHAGLVGQEPDGQVRLPFVWSGVTLFAQGASSVRVRLLPTGEDSVSVQ
                     VADVEGTPVASAPPACACGCCPRARTPSPYRSPTSKALRSRPPTPWSPGRSPPTGFGSP
                     GTLTTESCSASTGSPPPRHRPRPTHTGRCWEARNSRAPSPTPSTWCCPAPR"
     source          1..22802
                     /collection_date="2012"
                     /country="Germany: Cologne"
                     /db_xref="taxon:1736452"
                     /host="Arabidopsis thaliana"
                     /isolation_source="root"
                     /lat_lon="50.958 N 6.856 E"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. Root1310"
                     /strain="Root1310"
                     /submitter_seqid="contig_25"
     assembly_gap    3478
                     /estimated_length=1
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<3479..3881)
                     /locus_tag="ASD48_RS45470"
                     /old_locus_tag="ASD48_40980"
                     /pseudo=""
     CDS             complement(<3479..3881)
                     /NRPS_PKS="Domain: PKS_DH (0-115). E-value: 3.7e-42. Score:
                     136.4. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45470_PKS_DH.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF044701.1"
                     /locus_tag="ASD48_RS45470"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_40980"
                     /product="polyketide synthase dehydratase domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MELVIRAGDEAGCGRLDELTLEAPLVVPEDRSVSIQVRVGPATDT
                     GSRPVTVHSRTADDQDWVHHAGGQLTPDDTAEAFDLAVWPPADAEPLPLEGFYEGLTES
                     GYGYGPVFQGLRAAWRRGEELFAEVTPVAR"
     CDS_motif       complement(3537..3569)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45470_0001"
                     /evalue="3.80E-03"
                     /label="PKSI-DH_m3"
                     /locus_tag="ASD48_RS45470"
                     /protein_end="115"
                     /protein_start="104"
                     /score="10.2"
                     /tool="antismash"
                     /translation="GYGYGPVFQGL"
     aSDomain        complement(3537..3881)
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45470_PKS_DH.1"
                     /evalue="3.70E-42"
                     /label="ASD48_RS45470_PKS_DH.1"
                     /locus_tag="ASD48_RS45470"
                     /protein_end="115"
                     /protein_start="0"
                     /score="136.4"
                     /tool="antismash"
                     /translation="MELVIRAGDEAGCGRLDELTLEAPLVVPEDRSVSIQVRVGPATDT
                     GSRPVTVHSRTADDQDWVHHAGGQLTPDDTAEAFDLAVWPPADAEPLPLEGFYEGLTES
                     GYGYGPVFQGL"
     gene            complement(3856..>5190)
                     /locus_tag="ASD48_RS23990"
                     /old_locus_tag="ASD48_40985"
     CDS             complement(3856..>5190)
                     /NRPS_PKS="Domain: PKS_AT (18-316). E-value: 3.7e-95.
                     Score: 310.6. Matches aSDomain:
                     nrpspksdomains_ASD48_RS23990_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012901.4"
                     /locus_tag="ASD48_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_40985"
                     /product="acyltransferase domain-containing protein"
                     /protein_id="WP_242432713.1"
                     /sec_met_domain="PKS_AT (E-value: 6.8e-96, bitscore: 310.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PSAGVVSGVGDVRGRVVFVFPGQGSQWVGMAVELLESSVVFGEVF
                     AECDRVLGALTGWSVVDVVRGVVGAPSLERIEVLQPVLFAVQVSLARLWGSVGVVPAAV
                     VGHSQGEVAAAYVAGALSLEDAARVVVRRSDLFARELVGRGAVASVALGAVEVEERLXG
                     WGGRLSVAGRNGPAAVTVAGEVAALEEFVASCRGEGVRARVLGSTVASHSVQVDALRGR
                     IVELFADIVPRASRVPMYSTVTGRVIDTVGLDAGYWFDNARRPVDYEGAVRALVADGFR
                     FFVESSAHPVLTVGTQATCEDVGVEVVAVGSLRRGEGGLGRFVASVAEAFTRGLVVDWA
                     GLLVGGRRVELPTYAFQRRRFWLEDAGVAGGDAGVWGLAAAEHPLLGAAVHLADGEGVV
                     LTGRVSLRTHPWLVDHAVAGTVLLPGTAFVELAGYGVRGAGDPGR"
     CDS_motif       complement(3889..3957)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS23990_0005"
                     /evalue="2.70E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="433"
                     /protein_start="410"
                     /score="29.5"
                     /tool="antismash"
                     /translation="WLVDHAVAGTVLLPGTAFVELAG"
     aSDomain        complement(4240..5133)
                     /ASF="Neither malonyl-CoA or methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS23990_PKS_AT.1"
                     /evalue="3.70E-95"
                     /label="ASD48_RS23990_PKS_AT.1"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="316"
                     /protein_start="18"
                     /score="310.6"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Ethylmalonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFPGQGSQWVGMAVELLESSVVFGEVFAECDRVLGALTGWSVVDV
                     VRGVVGAPSLERIEVLQPVLFAVQVSLARLWGSVGVVPAAVVGHSQGEVAAAYVAGALS
                     LEDAARVVVRRSDLFARELVGRGAVASVALGAVEVEERLXGWGGRLSVAGRNGPAAVTV
                     AGEVAALEEFVASCRGEGVRARVLGSTVASHSVQVDALRGRIVELFADIVPRASRVPMY
                     STVTGRVIDTVGLDAGYWFDNARRPVDYEGAVRALVADGFRFFVESSAHPVLTVGTQAT
                     CEDVGVEVVAVGSLRRG"
     CDS_motif       complement(4387..4431)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS23990_0004"
                     /evalue="4.40E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="267"
                     /protein_start="252"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LDAGYWFDNARRPVD"
     CDS_motif       complement(4786..4896)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS23990_0003"
                     /evalue="1.30E-19"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="134"
                     /protein_start="97"
                     /score="61.9"
                     /tool="antismash"
                     /translation="GVVPAAVVGHSQGEVAAAYVAGALSLEDAARVVVRRS"
     CDS_motif       complement(4903..4971)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS23990_0002"
                     /evalue="1.30E-10"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="95"
                     /protein_start="72"
                     /score="33.2"
                     /tool="antismash"
                     /translation="LERIEVLQPVLFAVQVSLARLWG"
     CDS_motif       complement(5083..5139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS23990_0001"
                     /evalue="1.90E-10"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ASD48_RS23990"
                     /protein_end="35"
                     /protein_start="16"
                     /score="32.1"
                     /tool="antismash"
                     /translation="VFVFPGQGSQWVGMAVELL"
     assembly_gap    5191
                     /estimated_length=1
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(5523..6107)
                     /locus_tag="ASD48_RS46200"
                     /old_locus_tag="ASD48_40995"
     CDS             complement(5523..6107)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (0-153). E-value:
                     4.9e-64. Score: 208.7. Matches aSDomain:
                     nrpspksdomains_ASD48_RS46200_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014819.4"
                     /locus_tag="ASD48_RS46200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_40995"
                     /product="polyketide synthase"
                     /protein_id="WP_348983226.1"
                     /sec_met_domain="mod_KS (E-value: 4.4e-83, bitscore: 268.9,
                     seeds: 217, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPNGPSQQRVIRAALANAGLTPNDVDAVEAHGTGTALGDPIEA
                     QALLATYGQGRPEGRPLLLGSIKSNVAHPQAAAGVTGVIKMVMALRNEMLPKTLHAEEP
                     SPHVDWSAGDVELLTEAREWPQVERPWRAGVSSFGMSGTNAHVIVEQAPESSVEAVGER
                     VPVGVVPWVVSARSAEGLAGQAERLVRRGGG"
     aSDomain        complement(5649..6107)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS46200_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="4.90E-64"
                     /label="ASD48_RS46200_PKS_KS.1"
                     /locus_tag="ASD48_RS46200"
                     /protein_end="153"
                     /protein_start="0"
                     /score="208.7"
                     /tool="antismash"
                     /translation="MTAPNGPSQQRVIRAALANAGLTPNDVDAVEAHGTGTALGDPIEA
                     QALLATYGQGRPEGRPLLLGSIKSNVAHPQAAAGVTGVIKMVMALRNEMLPKTLHAEEP
                     SPHVDWSAGDVELLTEAREWPQVERPWRAGVSSFGMSGTNAHVIVEQAP"
     CDS_motif       complement(5976..6020)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS46200_0001"
                     /evalue="2.30E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="ASD48_RS46200"
                     /protein_end="44"
                     /protein_start="29"
                     /score="15.9"
                     /tool="antismash"
                     /translation="VEAHGTGTALGDPIE"
     gene            complement(6104..14797)
                     /locus_tag="ASD48_RS45480"
                     /old_locus_tag="ASD48_41000"
     CDS             complement(6104..14797)
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (14-456). E-value:
                     1.3e-153. Score: 503.9. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (569-865). E-value: 2.9e-92.
                     Score: 301.1. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_AT.1"
                     /NRPS_PKS="Domain: ACP (999-1064). E-value: 1.6e-20. Score:
                     65.2. Matches aSDomain: nrpspksdomains_ASD48_RS45480_ACP.1"
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (1090-1508). E-value:
                     1.6e-169. Score: 556.2. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_KS.2"
                     /NRPS_PKS="Domain: PKS_AT (1617-1918). E-value: 4.3e-110.
                     Score: 359.7. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_AT.2"
                     /NRPS_PKS="Domain: PKS_KR (2255-2434). E-value: 1.3e-58.
                     Score: 189.9. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (2550-2623). E-value: 3.8e-33.
                     Score: 105.6. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_ACP.2"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (2650-2890). E-value:
                     1.9e-95. Score: 312.2. Matches aSDomain:
                     nrpspksdomains_ASD48_RS45480_PKS_KS.3"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF045894.1"
                     /locus_tag="ASD48_RS45480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41000"
                     /product="type I polyketide synthase"
                     /protein_id="WP_057603773.1"
                     /sec_met_domain="hyb_KS (E-value: 3.7e-174, bitscore:
                     569.0, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 8e-111, bitscore: 359.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 5.6e-56, bitscore:
                     178.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-17, bitscore:
                     53.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.2e-117, bitscore:
                     382.9, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 6.4e-89, bitscore:
                     287.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVASPDVTFPPAEPIAVVGVGCRLPGGVRDLGSLGRMLRSGGTVL
                     EEVPEDRWGRDLHDAAEQDAPGTITHHVGAFLEDVDRFDAPYFGITPREAAAIDPQQRL
                     LMEVASEAMADSGRARQDWRGTRTGVYVGLLANDYHLLHAKSLGPQGVSPHYITGMEFS
                     FAAGRLAYTFDLRGPAVAVNSACSSSLYAVHQACQSLRAGDIDTALAGGVSLLLSPEIS
                     VFMSRIGAFSPSGRCRPFDAEADGIVRGEGCGVVVLKRLADALADGDRVHAVIRGSAVN
                     NDGSSVGLTAPNASAQAAVVRSALAAARVGTDGVDYVEAHGTGTPLGDMIELGTLSEVY
                     GAGRGDALPLVVGSHKAVFGHTDAAAGITGLIKSIWILGAGHVPAQPGIDELTPAVDWD
                     AGGIAVSLAGTDLTAPGRETASGQEASGQETASARPLRAGVSAFGLSGTNVHLIAEAPP
                     RQEAPTDAPADGPTGRPHVLLVSAPRPEGLVEQVARMREQLSRDDVPLTDLVASAATRR
                     THEDHRYAAVGTDRETLIEALDAVTGPADLEDLPDGAYADRLDPAGEPAPVFVYSGQGS
                     QWAGMAADLYGTDPDVTDTLDECDALIRTEASWSLLDELRRTDDSGLDRTDLAQPAIFA
                     VQVALTRWLTRRGITPTAVIGHSVGEIAAAHTAGVLPLPDAVRLIVRRGRILQDTAGTG
                     RMLAVQGDPGTVADLLDGSGLPAVVAAINGPASVVVAGPDDAVTEAQRLLEGHGLRCRR
                     TRVDYPFHSPLVAECGPRLRDALAGLTPARPTLRLLSSVDPDTDVGPLDAAYWARNITE
                     PVRLWPAVDRLLAEDEAHTLLEIGPHPVLLQPLADAARRRGLHRPVLSTLRRDEPGAVA
                     LHRTLARLHVTGTGVDWTTATGRPHRFRDLPLPSWGGDRYWLPGVERGHHEPMRDRDAH
                     PAVTEPPTTAPTGGTPARTTTAPTHETPGTTAPTGGTPAPAAATAPADLPPPATAARSS
                     ARTVHRIDAVVREVLGLGPDQPLPRRRGLFEQGLDSLTAVTLGKRLEEAFAVRLPSTVV
                     FEHPSIQALAAHLAEATAAEPARHPSPEETPAPAAASADDDAVAVIGMSCRLPGASSPE
                     EFWSLLTEGRNAVAAPPPGRRDDPIWDEAGPDVPTDGGYLADVSGFDAAFFHISPREAA
                     SLDPQQRLTLEVAWEALEDSGYPAAALLERQAGVYVGLNTADYHELLTRDMANIDLYYG
                     TGNTFAASAGRLSYFLGLHGPSLAVDTACSASLTAVHLACQGLRAGDCEIALVGGANVI
                     ASPTVSVAMSAGGALAPDGRCKTFDEAADGYGRGEGAVMLILKPLAAARRDGDRVYALL
                     RGSAVNQDGDSGGFTVPSASAQSALIRQALDRAGWEPREVDYVEAHGTGTPLGDPIEIH
                     GLADALGPGRDAGNPLLVGSAKANIGHLEAAAGITGLLKVVLSVHHGEIPPHLVDRPSS
                     RIDWDALPVRLTTGRSPWPDRDRPRRAGVSSFGFSGSNAHVLVEQAPHTADVPPAAEPA
                     DPPLALLPWVVSARGAAALRGQAARLARFVAAHPGLDPVDATYSLATTRSLLEHRAVVL
                     ARPGDQDTVRTALTALADGGSADDVISAGASGEGLTAFLFSGQGSQRVGMGRQLYDRFP
                     VFATALDEALAQLDRDGNGALRDILFAEPGTDAARLLDRTEYTQSALFAVESALFRLLA
                     SWGLEPDYLMGHSIGELAAAHAAGVLSLSDAARLVTARGRLMQALPEGGAMIAVAAPEA
                     EVADALAASGHRDRLDIAAVNGRSSTVLSGDEEAAAALAAVLAARGHKTKRLRVSHAFH
                     SPHMDAMLDDFREVAESVTYHAPHLPVISNVTGRLAEPGELCSADYWVRHVRAAVRFAD
                     GVRELDRLGVTTFLELGPDGVLAALSEESLDERPDAVAVPLLRKDRPEDEAIITAVATA
                     FVHGVKVNWQALLPRGRRVPLPTYAFQRRRHWLRRPEAPTAARPGPDRPEARFWAAVDQ
                     GDRTELARALGLPEDGPSALDDLLPTLSAWRQGNRERTVLDSWRYRVVWRPAPDTEPAP
                     VTGTWLVLTSTHTADHPWTQHAGDALAERGAHVVHLPVDPARADRTALADLLTRATGDR
                     PERGGVLSLLALDETPHPEHPDLAVGVTATLTLAQALGDADIDLPLWCVTQGAVTVGGT
                     DLVRRPEQAQIWGLGRVVGLEHPHRWGGLVDLPEQPDPHAVRHLCAALGARGPEDQLAV
                     RATGTLVRRLVRAPLADTPAPRPWKPRGTVLVVGGTGALGGHLAHWLADHGAERLVLTG
                     RRGSDAPGAAELRAELEAKGVLVTIAACDATDREALATVIERLRADGPPLRAVLHTAVV
                     ADVGPLTETTVDRYAQAVRAKVVGGRNLDALLDTDELDAFVLFSSIAGVWGSGDEGPYA
                     AANAYLDALAERRRAGGLPATSVAWGIWDAFNDRAEDTSMRELLTRRSIRQGLPRLDPR
                     LAFQALRQALDHDETNVVVSDVTWERFAALFTMARPRPLLDEIPEARLVTTDENPDPSD
                     TDTGTDDGSELIRRLTGLPEAGQERLLLDVVCAQAASVLGHGSTEDLDTERPFRDLGFD
                     SLTAVELRRRLNQATGLRLPPSLVFDHPSPVALARHLRTELTAGQPHQDERPPSPTAKA
                     APPDPEDDPIAIVGMACRLPGAIRSPEDLWQTVADGRDIVAGLPTDRGWDLERLYDADM
                     DAPGRSYVRHGAFLENAGDFDADFFGIAPREALAMDPQQRLLLETAWEAMERAGVTPAS
                     LRGTQVGVFVGAGADGYATAENRVPEEAEGFAVTGSAGSVMSGRIAYTFGLEGPAVTVD
                     TACSSSLVALHLASQALRAGECSMTLAGGVSLLASPKGLVEFSRLRALAPDGRSKAFSA
                     AADGTGWGEGVGMRTVRATA"
     aSDomain        complement(6128..6847)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_KS.3"
                     /domain_subtypes="Modular-KS"
                     /evalue="1.90E-95"
                     /label="ASD48_RS45480_PKS_KS.3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2890"
                     /protein_start="2650"
                     /score="312.2"
                     /tool="antismash"
                     /translation="IAIVGMACRLPGAIRSPEDLWQTVADGRDIVAGLPTDRGWDLERL
                     YDADMDAPGRSYVRHGAFLENAGDFDADFFGIAPREALAMDPQQRLLLETAWEAMERAG
                     VTPASLRGTQVGVFVGAGADGYATAENRVPEEAEGFAVTGSAGSVMSGRIAYTFGLEGP
                     AVTVDTACSSSLVALHLASQALRAGECSMTLAGGVSLLASPKGLVEFSRLRALAPDGRS
                     KAFSAAADGTGWGEGVGM"
     CDS_motif       complement(6137..6175)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0028"
                     /evalue="1.50E-01"
                     /label="PKSI-KS_m4"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2887"
                     /protein_start="2874"
                     /score="5.9"
                     /tool="antismash"
                     /translation="FSAAADGTGWGEG"
     CDS_motif       complement(6317..6364)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0027"
                     /evalue="1.50E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2827"
                     /protein_start="2811"
                     /score="20.1"
                     /tool="antismash"
                     /translation="GPAVTVDTACSSSLVA"
     CDS_motif       complement(6458..6487)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0026"
                     /evalue="1.60E+01"
                     /label="PKSI-KS_m4"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2780"
                     /protein_start="2770"
                     /score="-0.0"
                     /tool="antismash"
                     /translation="AGADGYATAE"
     CDS_motif       complement(6566..6592)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0025"
                     /evalue="5.20E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2744"
                     /protein_start="2735"
                     /score="6.9"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(6929..7147)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_ACP.2"
                     /evalue="3.80E-33"
                     /label="ASD48_RS45480_ACP.2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2623"
                     /protein_start="2550"
                     /score="105.6"
                     /tool="antismash"
                     /translation="LDVVCAQAASVLGHGSTEDLDTERPFRDLGFDSLTAVELRRRLNQ
                     ATGLRLPPSLVFDHPSPVALARHLRTEL"
     aSModule        complement(6929..11527)
                     /complete
                     /domains="nrpspksdomains_ASD48_RS45480_PKS_KS.2"
                     /domains="nrpspksdomains_ASD48_RS45480_PKS_AT.2"
                     /domains="nrpspksdomains_ASD48_RS45480_PKS_KR.1"
                     /domains="nrpspksdomains_ASD48_RS45480_ACP.2"
                     /locus_tags="ASD48_RS45480"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(7496..8032)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_KR.1"
                     /evalue="1.30E-58"
                     /label="ASD48_RS45480_PKS_KR.1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2434"
                     /protein_start="2255"
                     /score="189.9"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GTVLVVGGTGALGGHLAHWLADHGAERLVLTGRRGSDAPGAAELR
                     AELEAKGVLVTIAACDATDREALATVIERLRADGPPLRAVLHTAVVADVGPLTETTVDR
                     YAQAVRAKVVGGRNLDALLDTDELDAFVLFSSIAGVWGSGDEGPYAAANAYLDALAERR
                     RAGGLPATSVAWGIWD"
     CDS_motif       complement(7541..7651)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0024"
                     /evalue="6.70E-17"
                     /label="PKSI-KR_m4"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2419"
                     /protein_start="2382"
                     /score="54.0"
                     /tool="antismash"
                     /translation="LDAFVLFSSIAGVWGSGDEGPYAAANAYLDALAERRR"
     CDS_motif       complement(7931..8029)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0023"
                     /evalue="2.50E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="2289"
                     /protein_start="2256"
                     /score="42.5"
                     /tool="antismash"
                     /translation="TVLVVGGTGALGGHLAHWLADHGAERLVLTGRR"
     aSDomain        complement(9044..9946)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_AT.2"
                     /evalue="4.30E-110"
                     /label="ASD48_RS45480_PKS_AT.2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1918"
                     /protein_start="1617"
                     /score="359.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQRVGMGRQLYDRFPVFATALDEALAQLDRDGNGALRDI
                     LFAEPGTDAARLLDRTEYTQSALFAVESALFRLLASWGLEPDYLMGHSIGELAAAHAAG
                     VLSLSDAARLVTARGRLMQALPEGGAMIAVAAPEAEVADALAASGHRDRLDIAAVNGRS
                     STVLSGDEEAAAALAAVLAARGHKTKRLRVSHAFHSPHMDAMLDDFREVAESVTYHAPH
                     LPVISNVTGRLAEPGELCSADYWVRHVRAAVRFADGVRELDRLGVTTFLELGPDGVLAA
                     LSEESLDERPDAVAVPLLRK"
     CDS_motif       complement(9110..9139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0022"
                     /evalue="3.80E+00"
                     /label="PKSI-AT-M_m9"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1896"
                     /protein_start="1886"
                     /score="1.6"
                     /tool="antismash"
                     /translation="FLELGPDGVL"
     CDS_motif       complement(9182..9217)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0021"
                     /evalue="6.80E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1872"
                     /protein_start="1860"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YWVRHVRAAVRF"
     CDS_motif       complement(9440..9478)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0020"
                     /evalue="7.30E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1786"
                     /protein_start="1773"
                     /score="9.8"
                     /tool="antismash"
                     /translation="AAVNGRSSTVLSG"
     CDS_motif       complement(9578..9700)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0019"
                     /evalue="2.60E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1740"
                     /protein_start="1699"
                     /score="74.3"
                     /tool="antismash"
                     /translation="GLEPDYLMGHSIGELAAAHAAGVLSLSDAARLVTARGRLMQ"
     CDS_motif       complement(9713..9775)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0018"
                     /evalue="9.10E-02"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1695"
                     /protein_start="1674"
                     /score="6.5"
                     /tool="antismash"
                     /translation="LDRTEYTQSALFAVESALFRL"
     CDS_motif       complement(9896..9949)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0017"
                     /evalue="9.70E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1634"
                     /protein_start="1616"
                     /score="18.0"
                     /tool="antismash"
                     /translation="FLFSGQGSQRVGMGRQLY"
     aSDomain        complement(10274..11527)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_KS.2"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="1.60E-169"
                     /label="ASD48_RS45480_PKS_KS.2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1508"
                     /protein_start="1090"
                     /score="556.2"
                     /tool="antismash"
                     /translation="VAVIGMSCRLPGASSPEEFWSLLTEGRNAVAAPPPGRRDDPIWDE
                     AGPDVPTDGGYLADVSGFDAAFFHISPREAASLDPQQRLTLEVAWEALEDSGYPAAALL
                     ERQAGVYVGLNTADYHELLTRDMANIDLYYGTGNTFAASAGRLSYFLGLHGPSLAVDTA
                     CSASLTAVHLACQGLRAGDCEIALVGGANVIASPTVSVAMSAGGALAPDGRCKTFDEAA
                     DGYGRGEGAVMLILKPLAAARRDGDRVYALLRGSAVNQDGDSGGFTVPSASAQSALIRQ
                     ALDRAGWEPREVDYVEAHGTGTPLGDPIEIHGLADALGPGRDAGNPLLVGSAKANIGHL
                     EAAAGITGLLKVVLSVHHGEIPPHLVDRPSSRIDWDALPVRLTTGRSPWPDRDRPRRAG
                     VSSFGFSGSNAHVLVEQAP"
     CDS_motif       complement(10493..10537)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0016"
                     /evalue="3.60E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1435"
                     /protein_start="1420"
                     /score="10.1"
                     /tool="antismash"
                     /translation="GSAKANIGHLEAAAG"
     CDS_motif       complement(10598..10645)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0015"
                     /evalue="2.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1400"
                     /protein_start="1384"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YVEAHGTGTPLGDPIE"
     CDS_motif       complement(10838..10876)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0014"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1320"
                     /protein_start="1307"
                     /score="11.9"
                     /tool="antismash"
                     /translation="FDEAADGYGRGEG"
     CDS_motif       complement(11018..11065)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0013"
                     /evalue="2.50E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1260"
                     /protein_start="1244"
                     /score="16.5"
                     /tool="antismash"
                     /translation="GPSLAVDTACSASLTA"
     CDS_motif       complement(11267..11293)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0012"
                     /evalue="1.50E-01"
                     /label="PKSI-KS_m2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1177"
                     /protein_start="1168"
                     /score="5.6"
                     /tool="antismash"
                     /translation="DPQQRLTLE"
     aSDomain        complement(11606..11800)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_ACP.1"
                     /evalue="1.60E-20"
                     /label="ASD48_RS45480_ACP.1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="1064"
                     /protein_start="999"
                     /score="65.2"
                     /tool="antismash"
                     /translation="VREVLGLGPDQPLPRRRGLFEQGLDSLTAVTLGKRLEEAFAVRLP
                     STVVFEHPSIQALAAHLAEA"
     aSModule        complement(11606..14755)
                     /complete
                     /domains="nrpspksdomains_ASD48_RS45480_PKS_KS.1"
                     /domains="nrpspksdomains_ASD48_RS45480_PKS_AT.1"
                     /domains="nrpspksdomains_ASD48_RS45480_ACP.1"
                     /locus_tags="ASD48_RS45480"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(12203..13090)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_AT.1"
                     /evalue="2.90E-92"
                     /label="ASD48_RS45480_PKS_AT.1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="865"
                     /protein_start="569"
                     /score="301.1"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VYSGQGSQWAGMAADLYGTDPDVTDTLDECDALIRTEASWSLLDE
                     LRRTDDSGLDRTDLAQPAIFAVQVALTRWLTRRGITPTAVIGHSVGEIAAAHTAGVLPL
                     PDAVRLIVRRGRILQDTAGTGRMLAVQGDPGTVADLLDGSGLPAVVAAINGPASVVVAG
                     PDDAVTEAQRLLEGHGLRCRRTRVDYPFHSPLVAECGPRLRDALAGLTPARPTLRLLSS
                     VDPDTDVGPLDAAYWARNITEPVRLWPAVDRLLAEDEAHTLLEIGPHPVLLQPLADAAR
                     RRGLHRPVLSTLRRD"
     CDS_motif       complement(12275..12304)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0011"
                     /evalue="7.80E-02"
                     /label="PKSI-AT-M_m9"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="841"
                     /protein_start="831"
                     /score="6.5"
                     /tool="antismash"
                     /translation="LLEIGPHPVL"
     CDS_motif       complement(12350..12397)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0010"
                     /evalue="1.40E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="816"
                     /protein_start="800"
                     /score="11.3"
                     /tool="antismash"
                     /translation="LDAAYWARNITEPVRL"
     CDS_motif       complement(12602..12640)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0009"
                     /evalue="1.90E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="732"
                     /protein_start="719"
                     /score="11.5"
                     /tool="antismash"
                     /translation="AAINGPASVVVAG"
     CDS_motif       complement(12734..12856)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0008"
                     /evalue="2.60E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="688"
                     /protein_start="647"
                     /score="67.8"
                     /tool="antismash"
                     /translation="GITPTAVIGHSVGEIAAAHTAGVLPLPDAVRLIVRRGRILQ"
     CDS_motif       complement(12869..12931)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0007"
                     /evalue="9.80E-05"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="643"
                     /protein_start="622"
                     /score="15.4"
                     /tool="antismash"
                     /translation="LDRTDLAQPAIFAVQVALTRW"
     CDS_motif       complement(13040..13096)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0006"
                     /evalue="1.70E-07"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="586"
                     /protein_start="567"
                     /score="23.3"
                     /tool="antismash"
                     /translation="VFVYSGQGSQWAGMAADLY"
     aSDomain        complement(13430..14755)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS45480_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="1.30E-153"
                     /label="ASD48_RS45480_PKS_KS.1"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="456"
                     /protein_start="14"
                     /score="503.9"
                     /tool="antismash"
                     /translation="IAVVGVGCRLPGGVRDLGSLGRMLRSGGTVLEEVPEDRWGRDLHD
                     AAEQDAPGTITHHVGAFLEDVDRFDAPYFGITPREAAAIDPQQRLLMEVASEAMADSGR
                     ARQDWRGTRTGVYVGLLANDYHLLHAKSLGPQGVSPHYITGMEFSFAAGRLAYTFDLRG
                     PAVAVNSACSSSLYAVHQACQSLRAGDIDTALAGGVSLLLSPEISVFMSRIGAFSPSGR
                     CRPFDAEADGIVRGEGCGVVVLKRLADALADGDRVHAVIRGSAVNNDGSSVGLTAPNAS
                     AQAAVVRSALAAARVGTDGVDYVEAHGTGTPLGDMIELGTLSEVYGAGRGDALPLVVGS
                     HKAVFGHTDAAAGITGLIKSIWILGAGHVPAQPGIDELTPAVDWDAGGIAVSLAGTDLT
                     APGRETASGQEASGQETASARPLRAGVSAFGLSGTNVHLIAEA"
     CDS_motif       complement(13697..13741)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0005"
                     /evalue="5.10E-01"
                     /label="PKSI-KS_m6"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="367"
                     /protein_start="352"
                     /score="4.3"
                     /tool="antismash"
                     /translation="GSHKAVFGHTDAAAG"
     CDS_motif       complement(13802..13849)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0004"
                     /evalue="6.60E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="332"
                     /protein_start="316"
                     /score="12.0"
                     /tool="antismash"
                     /translation="YVEAHGTGTPLGDMIE"
     CDS_motif       complement(14042..14080)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0003"
                     /evalue="1.10E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="252"
                     /protein_start="239"
                     /score="12.1"
                     /tool="antismash"
                     /translation="FDAEADGIVRGEG"
     CDS_motif       complement(14222..14269)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0002"
                     /evalue="2.30E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="192"
                     /protein_start="176"
                     /score="13.7"
                     /tool="antismash"
                     /translation="GPAVAVNSACSSSLYA"
     CDS_motif       complement(14477..14503)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS45480_0001"
                     /evalue="1.00E-01"
                     /label="PKSI-KS_m2"
                     /locus_tag="ASD48_RS45480"
                     /protein_end="107"
                     /protein_start="98"
                     /score="6.0"
                     /tool="antismash"
                     /translation="DPQQRLLME"
     gene            complement(14868..15143)
                     /locus_tag="ASD48_RS24010"
                     /old_locus_tag="ASD48_41005"
     CDS             complement(14868..15143)
                     /NRPS_PKS="Domain: PP-binding (25-81). E-value: 7.1e-07.
                     Score: 21.4. Matches aSDomain:
                     nrpspksdomains_ASD48_RS24010_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048986.1"
                     /locus_tag="ASD48_RS24010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41005"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_242432714.1"
                     /sec_met_domain="PP-binding (E-value: 1e-07, bitscore:
                     22.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPVSEEETSKRITEFIRERFLDGDPQGELEPGSPLLEWGVLNS
                     LRVARLIAFIRSDLGVPVSAMEINPDNLRDVRSITAMVTRLARAGA"
     aSDomain        complement(14901..15068)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS24010_PP-binding.1"
                     /evalue="7.10E-07"
                     /label="ASD48_RS24010_PP-binding.1"
                     /locus_tag="ASD48_RS24010"
                     /protein_end="81"
                     /protein_start="25"
                     /score="21.4"
                     /tool="antismash"
                     /translation="DPQGELEPGSPLLEWGVLNSLRVARLIAFIRSDLGVPVSAMEINP
                     DNLRDVRSITA"
     gene            complement(15195..16685)
                     /locus_tag="ASD48_RS24015"
                     /old_locus_tag="ASD48_41010"
     CDS             complement(15195..16685)
                     /NRPS_PKS="Domain: AMP-binding (9-394). E-value: 1.4e-94.
                     Score: 309.0. Matches aSDomain:
                     nrpspksdomains_ASD48_RS24015_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000110: Other (67% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981363.1"
                     /locus_tag="ASD48_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41010"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_057603774.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-101, bitscore:
                     329.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLHQLLVDTAAKEPDRLAVAGTAARLTYGELDSTANALAHRLRA
                     LGVGPGDRVVLWSDKSPAVVAAMQAVLRLGAAYVPADGALPIARVAAMADDCSAAALLA
                     PADRLAPVADVLGPRCPAADLAQRPDPAAEPLNALVAPDDLAYILYTSGSTGAPKGVCI
                     SHRNARAFVDWAVEELAPGPQDRFSNHAPFTFDLSVLDLYAAFSAGASVHLIPSELAYA
                     PEQLVEFLHDRQITVWYSVPSALTLMMRDGGLLDRPAPRALRTVLFAGEPFPLPGVRAL
                     AGWTDARLLNLYGPTETNVCTRHEVRPTDLDGDRPLPIGTAVSGDRAWAEGPDGRLAAP
                     GEEGELLVDGPTVMLGYWGREPHTGPYRTGDLVRPLPDGSFAYLGRRDHMVKVRGHRVE
                     LGEVESVLALHPDVAEAAAVVVGSGMDGRLVAFVVPEPDRRPGVLSLVRHAAQRLPRYM
                     VADEVRVLPGLPRTRNGKVDRLALRDTAEAPAPGAAAQ"
     CDS_motif       complement(15474..15539)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS24015_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ASD48_RS24015"
                     /protein_end="404"
                     /protein_start="382"
                     /score="36.2"
                     /tool="antismash"
                     /translation="YLGRRDHMVKVRGHRVELGEVE"
     aSDomain        complement(15504..16658)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS24015_AMP-binding.1"
                     /evalue="1.40E-94"
                     /label="ASD48_RS24015_AMP-binding.1"
                     /locus_tag="ASD48_RS24015"
                     /protein_end="394"
                     /protein_start="9"
                     /score="309.0"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="TAAKEPDRLAVAGTAARLTYGELDSTANALAHRLRALGVGPGDRV
                     VLWSDKSPAVVAAMQAVLRLGAAYVPADGALPIARVAAMADDCSAAALLAPADRLAPVA
                     DVLGPRCPAADLAQRPDPAAEPLNALVAPDDLAYILYTSGSTGAPKGVCISHRNARAFV
                     DWAVEELAPGPQDRFSNHAPFTFDLSVLDLYAAFSAGASVHLIPSELAYAPEQLVEFLH
                     DRQITVWYSVPSALTLMMRDGGLLDRPAPRALRTVLFAGEPFPLPGVRALAGWTDARLL
                     NLYGPTETNVCTRHEVRPTDLDGDRPLPIGTAVSGDRAWAEGPDGRLAAPGEEGELLVD
                     GPTVMLGYWGREPHTGPYRTGDLVRPLPDGSFAYLGRRDHMVKVR"
     CDS_motif       complement(15600..15668)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS24015_0003"
                     /evalue="1.50E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="ASD48_RS24015"
                     /protein_end="362"
                     /protein_start="339"
                     /score="20.6"
                     /tool="antismash"
                     /translation="PGEEGELLVDGPTVMLGYWGREP"
     CDS_motif       complement(16191..16250)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS24015_0002"
                     /evalue="2.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="ASD48_RS24015"
                     /protein_end="165"
                     /protein_start="145"
                     /score="32.0"
                     /tool="antismash"
                     /translation="AYILYTSGSTGAPKGVCISH"
     CDS_motif       complement(16440..16478)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASD48_RS24015_0001"
                     /evalue="1.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ASD48_RS24015"
                     /protein_end="82"
                     /protein_start="69"
                     /score="12.1"
                     /tool="antismash"
                     /translation="AVLRLGAAYVPAD"
     gene            complement(16682..17815)
                     /locus_tag="ASD48_RS24020"
                     /old_locus_tag="ASD48_41015"
     CDS             complement(16682..17815)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835236.1"
                     /locus_tag="ASD48_RS24020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41015"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_057603775.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.1e-16, bitscore:
                     49.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.2e-23, bitscore:
                     71.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.1e-39, bitscore:
                     123.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDLTEKQRQRYDDVLSAVRERLGEPPSGEPFTPARWQDAARIG
                     LTGLCLPTEFGGGGLGALDTALCLEAFGRGCPDTGLVFAVSAHLLACAVPIRDFADVSV
                     RGELLSGLASGELVAANAMTEDDAGSDLSRLAVTAERKDDGYLLNGEKSFASNAPAADV
                     LVTYGTSDPAAGFLGVTAFVLRADLPGVQVGEPFRKMGLSGCPAGRVAFRDCHVPTSHR
                     LGTEGQGSIIFQHSMGWERAILFAGYLGLMERQLEQCVRHARERRQFGHGIGEFQAVSH
                     RVVGMKQRLEAARLLLYRACWLMDQGRDHSTAVALSKTAVSEGAVANSLDAIQIFGGSG
                     YLSPAGIEQQLRDAVPSTIFSGTTDIQREIVAREIGL"
     gene            18117..18554
                     /locus_tag="ASD48_RS24025"
                     /old_locus_tag="ASD48_41020"
     CDS             18117..18554
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.4"
                     /locus_tag="ASD48_RS24025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41020"
                     /product="ester cyclase"
                     /protein_id="WP_057603776.1"
                     /sec_met_domain="PF07366 (E-value: 2e-34, bitscore: 107.7,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHQPSDTIAGLYEAFNSGDLETLRELIAPDAVIHLPGTAGDAEH
                     PPGTPRDREGWLGVWQFTQAFFPDMTATVQDIVQTGDLVATRCVARGTHSIEFMGVPPT
                     GRPFEMTMLNMSRVRDGRIVEHWTISDNVTMLAQLGVKASL"
     misc_feature    complement(18159..18170)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(18695..21511)
                     /locus_tag="ASD48_RS24030"
                     /old_locus_tag="ASD48_41025"
     CDS             complement(18695..21511)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="ASD48_RS24030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41025"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_079073955.1"
                     /transl_table=11
                     /translation="MFTCLIGRRPQRSPALERVNLCELTGCPTRMILVNREAELGLLKS
                     GLAECAAGRAKMIVVEGGVGCGKSELLDTFTEYATEQGAAVLRGMGIRSASDQPLALLR
                     QLLGQVPGWVPSEPGVGEQEFGEALHRLASRSPVVVCVDDAQYGDSRSLHHLLQAAGFT
                     RSARILLVFGDSLHLPRRDPVIKTELLRQSNSLRIRLGPLTKQGTAALLAAQGGDAQDR
                     PLVDRLHFITAGNPLLLRALLEECRPATADSGIADKIEPMEGGLYGQAVLASLYRSGPA
                     ALELGHALAVLDEPRAHAILPRLVDQPSALIDQNLQALTAAGMIAGTAFRHQAAVATVL
                     ADLAPDRRTALHSWVAVALHSAGYPASVVARHLLKARSAAQPWELIALRNAAEEALAED
                     DAVLAIDCLELAHEACPDPVQRIEIKMRLALITWRTNPAAAEYRHLPELLSAMRRGELS
                     PTSLGMLGKLLSAHGRIVEAMEVLRLSEDASCDVPRPVPGIHPTIASMWVRYGFHGVDF
                     PDSGQRGGAAQGPASDPGSLVNGSVPGIPLLRKSAEDVLIAAQDWSGSAESFLEMCSLT
                     DSMVAPVCSALKALLYSDQVEAAAQWCAKILDEATRRNIPGWQGVLAVVQGMIALRQGK
                     LEEAVASASMALEVVPERNGSVLVCGTSSILALAYTEMGRYDAAVRLLDQPVSQDWFDS
                     VYWLGYLRARGHFHLATNRSHAALSDFLRIGNLAGSWGIDHPMLVSWRTDAAQAWLQLG
                     EPSQAQQLLDAEVSQEFPGYGRLRGITLRLQAAIAPLTDRVQLLGRAVEEFDAGNDRLE
                     LAKALADLSEAHEALGNQTRADLVRRKGRHLAAECGADPLYRRMAAGGRNRMVAADSES
                     GSVRTEPKPGVDLTEAEYRVASLASYGHTNREISQQLYITVSTVEQHLTRIYQKLRITR
                     RQEIPVDL"
     misc_feature    complement(21194..21196)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21449..21451)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21588..21597
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.86"
                     /tool="antismash"
     gene            22372..>22802
                     /locus_tag="ASD48_RS24035"
                     /old_locus_tag="ASD48_41030"
                     /pseudo=""
     CDS             22372..>22802
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038778.1"
                     /locus_tag="ASD48_RS24035"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_41030"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEEIISAILADGTTSEDISGLRIPDTYRAVTIRKDEIGLFEGMAS
                     ADKDPRKSLHLDEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLPTFHFLKRYGATS
                     AMAARHDLPYHVIGSDLAGVVLRTGPGVNAWKPGDEVVA"
ORIGIN
        1 tggtctcgac ggtgggctcg ggcgcctcct cgatgatcac gtgcgcgttc gtcccactga
       61 tcccgaacga cgacacaccg gcgcggcgcg cacgccccac ctgcggccac tcgcgcgcct
      121 cggtcagcag ctccaccgca cccgccgacc agtccacatg cggcgacggc tcatcgacgt
      181 gcagcgtctt gggcagcacg ccgtgccgca acgccatcac ggtcttgatc agtcccgctg
      241 ctccggccgc ggcctgggtg tgcgcgatgt tggacttcac cgagcccagc cacagcggcc
      301 ggtcctcggg ccggtcctgg ccataggtgg cgatcagcgc ctgggcctcg atcgggtctc
      361 cgagtgtcgt accggtgccg tgggcctcga ccgcgtcgac gtcgtcggcc gacaggcggg
      421 cgttcgccag cgcggcccgg atcacgcgct gctgggacgg accgttcggc gccgtcaggc
      481 cgctgctggc gccgtcctgg ttcacggcgc tgccgcgtac gacggcgagg atctcgtggc
      541 cgttgcgccg ggcgtccgac aggcgctcca gcagcaccag gccgacgccc tccgcgaagc
      601 cgaagccgtc cgccgcggcg gagaacgcct tgcaccgtcc gtcgcgtgcg agggcgcgct
      661 gtcggctgaa ctcggtgagt tcgtggggtc ctgccatcac ggtcacgccg cccgcgaggg
      721 cgagcgagca ctcgccgccg cgcagggcct gaccggccag gtgcagtgcc accagggagg
      781 acgagcacgc cgtgtccacc gtgacggcgg ggccctccag accgaacgcg taggagatcc
      841 ggccggagac gacactgccg gtgctgccgg tcatggcgta accctcgacg cctggcggca
      901 tccggtccgg gccgggcagg tagtccgagc ccatggcgcc cgcgaacacg ccgacctggc
      961 tgccgcgcag cgactcggcc gggagaccgg cccgctcgaa cacctcccag gtcgcctcca
     1021 gcagcaggcg ctgctgcgga tccatcgcca gcgcctcacg cggcgagatc ccgaacagct
     1081 ccgcgtcgaa cgcgccggcg tcgtagacga acgcaccctc gcgcacgtag ctcttgcccg
     1141 gtacggccgg gtccgggtcg tacaacgtct ccaggtccca gccgcggtca ccgggcagcg
     1201 ccgagaccgc gtcgcggccc tcgctgacca ggcgccacag gtcctcgggg gactcgacac
     1261 cgccggggaa ccggcaggcc atgccgatga tcgccagcgg ttcgtcggcc gcggcggccg
     1321 ccgtcccgcg ggtctccccc gccgtccgcc tgccgccgac cacctcggtc cgcagatggc
     1381 gggcgagcgc gaggggggtc gggtggtcga agaccagggt cgagggcagt cgcagtcccg
     1441 tggcggtgtt gagccggttc cgcagctgga ccgcggtcag cgagtcgaag ccctgctcca
     1501 ggaagccacg ccgtggatcc acggcgtccg tcttcgcatg ccccagcacg gccacggcga
     1561 catcgcggac gaggtccagc aggagacgtt cctgttcctg ttctcccagg ggggccaggc
     1621 gctgggacag cgccgatgcc ggtacgccgg ccggtccgcc ggccgcggcg cgccgggcgg
     1681 ggaggcgtac gagaccgcgc agcaacggcg gaagcgcacc cgagccggcc tgggcgcgga
     1741 gggtggccag gtcgacgcgg atcggcacca gaagtgcccg ctcccccgcg gcgacggcgg
     1801 agtcgaacag ggccagcccc tgctcgttcg acagggccga ggcgcctgtg cgggagaatc
     1861 gtgcccggtc ggcatcgacc aggtgctcgc tcatgccgct gtcctcgtcc cacagccccc
     1921 aggccaggga aacggcgggc agaccctgcg ccctgcggtg ctgggcgagc gcgtccagga
     1981 aggtgttggc ggccgcgtag ttgccctgcc cggggttgcc gaacacaccg gcggccgacg
     2041 agaacaggac gaaggcccgc agatcgatgt tcaggtcctg ggtcgcctgg tgcagggtga
     2101 ccgcggcgtc caccttcggc cgcagtaccg ccgtcagccg ctcggaggtc aggccggtga
     2161 cggttccgtc gtccagcacg ccggccgagt ggacgaccgc cgtcagcggg tgctcctccg
     2221 gaatgtcggt caggagcgcg tcgaccgcgt cgcggtcggc catgtcgcag gcggcgatgg
     2281 tcacgttcgc gcccgcggcc gacagttcgg cgctcagttc gtcggccccc ggcgctccgg
     2341 cgccccgcct gctggtcagc agcaggtgac gtactcctcg ttccgcgacc agatggcggg
     2401 cgaggacccg gccgagcagg ccggtcccgc cggtgacgag gacggtgccg tcagggtccc
     2461 aggcggcttc gccggcttcg gggcgcacgg cttcggtggc ggtcaggcgc ggtgtcagta
     2521 cggtgccgcc acgtaccgcc atctgggttt cgccgacggc cagtacggag ctcaggaccg
     2581 gttcccagtc ggtcgcgtcg tcgacgtcga ccaggacgaa ccggtccggg ttctccgtct
     2641 gcgccgacct gaccaggccc caggccgcgg catgggacag atccgacacg tcgtcggtgc
     2701 ccaccccgac ggctccgcgg gtgacgacga cgagccggga ccgcgtggcg gccgggtcgg
     2761 acagccagtc ctggatcgcg gtgagcacct caccggtgac gtcatggacc acgtccgcga
     2821 gatccccgca cctcaccggg gtgcagggca gcaccacgta ctcggggtag ggctcggcgc
     2881 ccgcgagttc ctcgcctccc agcaccgccc agtgtgcgtc ggccgaggcc tgtgtctcgg
     2941 cggcggggag ccagtcgagg ccgaacagga ctccgtggtc agggtccccg gactgccgaa
     3001 gccggtcggt ggcgaccggc cgggtgacca gggcgtcggc ggacgcgacc ggagtgcctt
     3061 cgacgtcggc gacctgtacg gagacggagt cctcgcccgt gggcagcagc cgcacgcgca
     3121 cgctggaggg gcggacgcga ccggagtgcc ttcgacgtcg gcgacctgta cggagacgga
     3181 gtcctcgccc gtgggcagca gccgcacgcg cacgctggag gcgccctggg cgaacagcgt
     3241 caccccgctc cacacgaacg gcaggcgtac ctgcccgtcc ggctcctgtc ccacgagccc
     3301 cgcgtgcaag gccgcgtcca gcagcgccgg atggattccg aaccctgccg ccgcctcggc
     3361 ctcctccgcg ggcagagcga cctcggcgaa gagttcctcg ccgcgtcgcc aggccgcccg
     3421 caggccctgg aacaccggcc cgtagccgta gccggactcg gtcaggccct cgtagaancc
     3481 cgggccaccg gtgtcacctc ggcgaagagt tcctcgccgc gtcgccaggc cgcccgcagg
     3541 ccctggaaca ccggcccgta gccgtagccg gactcggtca ggccctcgta gaagccctcc
     3601 agcggaagcg gctcggcgtc ggccgggggc cacaccgcga ggtcgaacgc ctccgccgtg
     3661 tcgtccgggg tgagttgtcc tccggcatgg tggacccagt cttgatcgtc agccgtacgg
     3721 gagtggaccg tcacggggcg gctgccggtg tccgtggccg gaccgacccg cacctggatc
     3781 gagaccgaac ggtcttcggg cacgacgagc ggtgcttcga gggtgagttc gtcgaggcgt
     3841 ccgcagccgg cctcgtcacc ggcccggatc accagctcca cgaacgccgt acccggccag
     3901 ctccacgaac gccgtacccg gcagcagcac cgtccccgcc accgcgtgat ccaccagcca
     3961 cggatgcgtc cgcaacgaca cccgacccgt cagcaccaca ccctcaccgt cggccagatg
     4021 caccgccgca cccagcaacg gatgctcagc cgccgcaagc ccccacacac ccgcatcacc
     4081 acccgccacc ccagcgtcct ccagccaaaa acgccgccgc tgaaaggcat acgtcggcaa
     4141 ctccacccgc cgaccaccca ccagcaaccc cgcccagtcc accaccagac cccgcgtgaa
     4201 cgcctccgcc accgacgcca cgaaccggcc caaacccccc tcaccccgac gcagcgaccc
     4261 caccgccacc acctcgacac ccacgtcctc acacgtcgcc tgcgtaccca ccgtcaacac
     4321 cggatgcgca ctcgactcca cgaagaaacg aaaaccatca gccaccagcg cccgcaccgc
     4381 accctcgtaa tccaccggcc ggcgcgcatt gtcgaaccaa taccccgcat ccagcccaac
     4441 ggtgtcgatc acccgccccg tcaccgtcga atacatcggc acccgcgaag cccgcggaac
     4501 aatatccgcg aacaactcca caatccgccc acgcaacgca tccacctgca ccgaatgcga
     4561 cgccaccgtc gaacccagca cccgcgcccg caccccctcc ccccggcacg aagccacgaa
     4621 ctcctccaac gccgccacct cacccgcaac cgtcaccgca gccggaccat tacgccccgc
     4681 cacactcaac cgcccacccc agcccncaag ccgctcctcc acctcaaccg cacccaacgc
     4741 caccgacgcc accgcacccc gacccaccaa ctcccgcgca aacagatcac tacgccgcac
     4801 caccacccgc gccgcatcct ccaacgacaa agcacccgcc acatacgccg ccgccacctc
     4861 accctgcgaa tgacccacca ccgcagccgg caccaccccc accgaccccc acaaccgcgc
     4921 caacgacacc tgcaccgcga acaacaccgg ctgcaacacc tcgatccgct ccagcgacgg
     4981 cgcacccacc accccccgca ccacatccac caccgaccac cccgtcaacg cccccaacac
     5041 ccggtcacac tcggcgaaca cctccccgaa caccaccgac gactccagca actccaccgc
     5101 catacccacc cactgcgacc cctgaccagg gaaaacaaac accacccgac cccgcacatc
     5161 acccacaccc gacaccacac ccgcactcgg nctccaccgc catacccacc cactgcgacc
     5221 cctgaccagg gaaaacaaac accacccgac cccgcacatc acccacaccc gacaccacac
     5281 ccgcactcgg ttcaccggag accaacgcct ccaggcccgc cgtcaggtcc tcccggccgc
     5341 ggcccagcac caccgcccgc cgctccagca ccgagcgcga caccgccagt gagaacccga
     5401 catcgaccgg atccagctcc ggtcgcctgt cgacgagttc gagcagccgc tccgcctggc
     5461 cggccagtcc ctcagcgctc cgcgccgaca ccacccacgg caccaccccg accggaaccc
     5521 gctcacccac cgcctcgacg gacgagccgc tccgcctggc cggccagtcc ctcagcgctc
     5581 cgcgccgaca ccacccacgg caccaccccg accggaaccc gctcacccac cgcctcgacg
     5641 gacgactcng gcgcctgctc cacgatcacg tgcgcgttcg tcccgctcat cccgaacgag
     5701 gacacaccgg cccgccaggg gcgctcgacc tgcggccact cgcgggcctc ggtcagcaac
     5761 tccacgtcgc ccgcggacca gtcgacgtgc ggcgacggct cctcggcgtg cagtgtcttc
     5821 ggcagcatct cgttgcgcag ggccatcacc atcttgatga caccggtgac accggccgcg
     5881 gcctgggggt gggcgacgtt cgacttgatc gagccgagca gcaacggccg cccctcgggg
     5941 cgcccttggc cgtaggtggc gagcagcgcc tgggcctcga tcgggtcgcc cagggccgta
     6001 cccgtgccat gggcctcgac ggcgtcgacg tcgttcggcg tcaggccggc gttggccaac
     6061 gcggcccgga tgacacgctg ctgggacgga ccgttcggcg cggtcaggcc gttgctcgca
     6121 ccgtcctcat ccccacaccc tcaccccagc ccgtaccgtc ggccgccgcc gagaacgcct
     6181 tcgaccggcc gtcgggcgcc agggcacgca ggcggctgaa ctcgacgagg cccttggggc
     6241 tggcgagcag ggagacaccg ccggcgaggg tcatggagca ctcgccggcg cgcagggcct
     6301 ggctcgcgag gtggagggcc accagggacg acgagcaggc cgtgtcgacg gtcaccgccg
     6361 gcccttcgag gccgaaggtg taggcgatcc ggccggacat gacgcttccg gcgctgcccg
     6421 tgacggcgaa gccctcggcc tcttccggaa cgcggttctc ggcggtggcg tatccgtcgg
     6481 cgcccgcgcc gacgaagacg ccgacctggg tgccgcgcag ggaggccggg gtcactccgg
     6541 cgcgctccat ggcctcccag gcggtctcca ggagcagccg ctgctggggg tccatggcga
     6601 gtgcttcacg cggtgcgata ccgaagaagt cggcgtcgaa gtcgccggcg ttctcgagga
     6661 acgcgccgtg gcgtacgtag ctcctgccgg gggcgtccat gtcggcgtcg tagagccgtt
     6721 cgaggtccca gccgcggtcg gtgggcagac cggcgacgat gtcgcggccg tcggcgacgg
     6781 tctgccacag gtcttccggg gagcggatgg caccgggcag gcggcaggcc atgccgacga
     6841 tggcgatggg gtcgtcctcc gggtccggcg gcgctgcctt ggccgtgggc gacgggggcc
     6901 gctcgtcctg gtgcggctgt ccggccgtga gttcggtccg caggtggcgg gcgagggcca
     6961 cggggctggg gtggtcgaag acgagggagg gcggcagacg caggccggtt gcctggttga
     7021 ggcggcggcg cagttcgacg gcggtgaggg agtcgaaacc gaggtcgcgg aagggacgtt
     7081 cggtgtcgag gtcctcggtg ctgccgtggc cgagtacgga ggccgcctgt gcgcacacca
     7141 cgtcgaggag gaggcgttcc tgaccggcct ccgggagacc ggtgaggcga cggatcagct
     7201 cggatccgtc gtccgtgccg gtgtcggtgt ccgaggggtc gggattctcg tcggtggtga
     7261 cgaggcgcgc ctcggggatc tcgtcgagca gggggcgcgg gcgggccatg gtgaacaggg
     7321 cggcgaagcg ttcccaggtg acgtcgctga cgacgacgtt cgtctcgtcg tggtcgagtg
     7381 cctgccgcag ggcctggaag gcgaggcgcg ggtcgagacg gggcaggccc tggcggatcg
     7441 agcgccgggt gagcagctcg cgcatggagg tgtcctcggc gcggtcgttg aaggcgtccc
     7501 agatgcccca ggcgacggag gtggcgggca ggccgccggc ccgacggcgt tcggcgagcg
     7561 cgtcgaggta ggcgttggcg gccgcgtagg ggccttcgtc gccgctgccc cacacgcccg
     7621 cgatggagga gaacagcacg aacgcgtcga gttcgtcggt gtcgaggagg gcgtcgaggt
     7681 tgcggccgcc gacgaccttg gcgcgtacgg cctgtgcgta gcggtcgacg gtcgtctcgg
     7741 tgagcgggcc gacgtcggcg acgacggcgg tgtgcaggac cgcgcgcagg ggcggtccgt
     7801 cggcgcgcag ccgctcgatc acggtggcga gtgcctcgcg gtccgtggcg tcgcaggcgg
     7861 cgatggtgac gagaacgccc ttggcctcga gttcggcgcg cagttcggcg gcgccggggg
     7921 cgtcggatcc ccggcggccg gtgaggacga ggcgttcggc gccgtggtcg gcgagccagt
     7981 gggcgaggtg gccgccgagg gctccggtgc cgccgacgac gagcacggtg ccgcggggct
     8041 tccacggtcg tggtgcgggg gtgtcggcga ggggggcgcg caccaggcgt cgtacgaggg
     8101 tgccggtggc gcgtacggcc agttggtcct cggggccgcg ggcgccgagt gcggcgcaca
     8161 gatggcgtac ggcgtgcggg tcgggctgtt cggggagatc gacgaggccg ccccagcggt
     8221 gggggtgttc caggccgacg acgcggccca ggccccagat ctgggcctgt tcggggcgcc
     8281 ggacgagatc ggttccgccg acggtgacgg cgccttgggt gacgcaccac aggggcaggt
     8341 cgatgtcggc gtcgccgagg gcctgcgcga gggtgagggt ggcggtgacg ccgactgcga
     8401 ggtcggggtg ttcggggtgc ggggtctcgt cgagggcgag cagggagagg acaccgcccc
     8461 gctccgggcg gtcgccggtg gccctggtca gcaggtcggc gagtgccgtg cggtcggcgc
     8521 gcgccgggtc gacggggagg tggacgacgt gggcgccgcg ttcggcgagg gcgtcgccgg
     8581 cgtgctgtgt ccacgggtgg tcggcggtgt gggtggaggt gagaacgagc caggtgccgg
     8641 tgaccggcgc cggttccgtg tcgggggcgg gccgccagac gacccggtag cgccacgagt
     8701 ccaggacggt tcgttcccgg ttgccctgcc gccaggcgga cagggtcggc agcaggtcgt
     8761 ccagcgcgga cgggccgtcc tcgggcaggc cgagggcgcg ggcgagttcc gtgcggtcgc
     8821 cctggtcgac ggccgcccag aagcgggcct cgggccggtc gggaccgggg cgggcagccg
     8881 tgggggcttc ggggcgccgg agccagtggc ggcgccgctg gaaggcgtag gtgggcagcg
     8941 ggacgcgtcg gccgcggggc agcagggcct gccagttcac cttcacgccg tggacgaagg
     9001 cggtggccac ggcggtgatg atcgcctcgt cctcggggcg gtccttgcgc agcagcggga
     9061 cggcgaccgc gtccggccgt tcgtcgaggg attcctcgct cagggcggcg agcaccccgt
     9121 ccgggcccag ttccaggaag gtggtcacgc cgaggcggtc gagttcccga acgccgtcgg
     9181 cgaagcggac cgcggcccgg acgtgccgta cccagtagtc cgccgagcac agctcgccgg
     9241 gctcggcgag ccggccggtg acgttggaga tcacgggcag gtgcggcgcg tggtaggtga
     9301 cgctctcggc gacctcccgg aagtcgtcga gcatggcgtc catgtgcggc gagtggaagg
     9361 cgtggctgac gcgcaggcgc ttggtcttgt ggccgcgcgc ggcgagtacc gcggccagag
     9421 cggccgccgc ttcctcgtcg ccggagagca cggtggagga gcgtccgttg acggcggcga
     9481 tgtcgagccg gtcgcggtgg ccggacgcgg cgagggcgtc ggcgacctcg gcctccggtg
     9541 cggcgacggc gatcatggcg ccgccctcgg gcagggcctg catcagccgg ccgcgggcgg
     9601 tcaccagcct ggccgcgtcg ctcagcgaga gcacgccggc ggcgtgggcg gcggccagtt
     9661 cgccgatcga gtggcccatc aggtagtcgg gttcgaggcc ccaactggcc agaagccgga
     9721 acagggcgct ctccacggcg aacagcgcgc tctgggtgta ctcggtccgg tcgagcagcc
     9781 gggccgcgtc cgtgccgggc tcggcgaaca ggatgtcgcg cagcgcgccg ttcccgtcgc
     9841 ggtccagctg ggccagggcc tcgtcgaggg cagtggcgaa cacggggaag cggtcgtaca
     9901 actgccgtcc catcccgacg cgttggctgc cctgcccgct gaacaggaat gcggtgagcc
     9961 cctcccccga ggcgccggcg ctgatcacgt cgtcggcgct gccgccgtcg gcgagcgcgg
    10021 tgagggcggt acgtacggtg tcctggtcgc cgggcctggc gaggaccacg gcgcggtgct
    10081 ccagcagaga ccgggtggtg gccaatgagt acgtggcgtc cacggggtcg aggccggggt
    10141 gggcggcgac gaaccgggcc agcctggcgg cctgtccccg cagggcggcc gcgccacggg
    10201 cggagaccac ccagggcagc agcgcgaggg gcgggtctgc gggttcggcg gcgggcggga
    10261 cgtcggcggt gtggggcgcc tgttcgacga ggacgtgggc gttgctgccg ctgaagccga
    10321 aggaggagac cccggcccgg cgcgggcggt cccggtcggg ccagggggaa cggccggtgg
    10381 tgagtcgcac gggcagggcg tcccagtcga tgcggctgga ggggcggtcg acgaggtgcg
    10441 gcggtatctc accgtggtgc acggaaagga cgaccttgag cagtccggtg ataccggcgg
    10501 cggcttccag gtgtccgatg ttcgccttgg ccgagccgac gagcagcggg ttgccggcgt
    10561 cgcggcccgg gccgagggcg tcggccaggc cgtgtatctc gatggggtcg cccagggggg
    10621 tgccggtgcc gtgggcctcc acgtagtcga cctcgcgggg ctcccagccg gcccggtcca
    10681 gcgcctgccg gatcagggcg gactgcgcgg acgcgctcgg cacggtgaac ccgccgctgt
    10741 ccccgtcctg gttgacggcg ctgccgcgca gcagggcgta gacccggtcg ccgtcgcggc
    10801 gcgccgcggc cagcggtttg aggatgagca tgacggcgcc ctcgccgcgg ccgtatccgt
    10861 cggcggcctc gtcgaaggtc ttgcaacggc cgtcgggggc gagggcgccg cccgcggaca
    10921 tggccacgga caccgtcggg gaggcgatga cgttggcacc gccgacgagg gcgatctcgc
    10981 agtcaccggc ccgcagtccc tggcaggcga ggtgtaccgc ggtcagggac gccgagcagg
    11041 cggtgtccac ggcgaggctg ggcccgtgca gcccgaggaa gtacgacagt cggccggcgg
    11101 aggcggcgaa ggtgtttccg gtgccgtagt agaggtcgat gttggccatg tcgcgggtga
    11161 gcagttcgtg gtagtcggcc gtgttgaggc cgacgtacac acctgcctga cgctccagca
    11221 gggcggccgc ggggtagccg gagtcctcca gtgcctccca ggccacctcc agcgtgagcc
    11281 gctgctgcgg gtcgagcgag gccgcctcgc ggggggagat gtggaagaac gcggcgtcga
    11341 acccggagac gtcggccagg tagccgccgt cggtggggac atcgggtccg gcctcgtccc
    11401 agatcgggtc gtcccgccgc ccgggcggcg gggccgccac ggcgttccgg ccctcggtca
    11461 gcagggacca gaactcctcg ggcgaggacg ctcccggcag gcggcaggac atgccgatca
    11521 ccgcgacggc gtcgtcgtcc gcgctcgccg ccgccggtgc gggtgtctcc tcgggtgacg
    11581 ggtgccgtgc gggctcggcc gccgtcgctt ccgcgaggtg ggcggccagt gcctggatcg
    11641 acgggtgctc gaagacgacg gtggacggga gccgtaccgc gaaggcctct tcgagccgct
    11701 tgccgagggt gaccgcggtc agcgagtcca gcccctgttc gaacaggccg cgtcggcggg
    11761 gcagcggctg gtcggggccg agcccgagca cctcacggac gacggcgtcg atccggtgca
    11821 ccgtccgggc ggaggagcgc gcggcggtgg cgggcggggg caggtcggcc ggtgcggtcg
    11881 ccgcggccgg ggccggcgtc ccgccggtcg gggcggtggt gcccggcgtc tcgtgggtcg
    11941 gggcggtggt ggtccgggcc ggcgtgccgc cggtcggggc ggtggtgggc ggttccgtga
    12001 ccgccgggtg cgcgtcccgg tcccgcatcg gctcgtggtg tccgcgctcc acgccgggca
    12061 gccagtaccg gtcgccgccc caggaaggca gcggcaggtc ccggaagcgg tgcggcctgc
    12121 cggtggccgt cgtccagtcc acgccggtgc cggtgacgtg caggcgggcc agggtccggt
    12181 ggagcgccac cgcgcccggt tcgtcgcggc gcagggtgct cagcacggga cggtgcaggc
    12241 cgcgccggcg tgcggcgtcg gcgagcggct gcagcaggac cgggtgaggg ccgatctcca
    12301 ggagggtgtg ggcctcgtcc tcggcgagca gacggtcgac ggcgggccac agccgtacgg
    12361 gttcggtgat gttgcgggcc cagtaggcgg cgtcgagcgg gccgacgtcg gtgtcggggt
    12421 cgacgctgga gagcaggcgc agggtgggcc gcgccggggt gagaccggcg agtgcgtcgc
    12481 gcaggcgcgg gccgcactcg gcgacgagag ggctgtggaa ggggtagtcg acgcgggtgc
    12541 ggcggcagcg cagaccgtgt ccttcgagca ggcgctgcgc ctcggtgacg gcgtcgtcgg
    12601 gcccggcgac gacgacggag gcggggccgt tgatcgcggc gaccacggcc gggaggccgc
    12661 tgccgtcgag gaggtcggcg accgtgccgg ggtcgccctg caccgcgagc atgcgcccgg
    12721 ttcccgcggt gtcctgcagg atccgtccgc gccggacgat cagccgtacg gcgtcgggca
    12781 gggggaggac gcccgcggtg tgggcggcgg ctatctcgcc gacgctgtgg ccgatgacgg
    12841 ccgtcggggt gatgccgcgc cgggtgagcc agcgggtcag cgccacctgg acggcgaaga
    12901 tggccggctg ggcgaggtcg gtgcggtcga gtccgctgtc gtcggtgcgc cgcagttcgt
    12961 cgagaagcga ccaggacgcc tcggtgcgga tcagcgcgtc gcactcgtcg agggtgtcgg
    13021 tgacgtcggg gtcggtgccg tacaggtcgg cggccatgcc ggcccactgg ctgccctgtc
    13081 cggagtagac gaagacgggg gccggttcgc cggcggggtc cagccggtcc gcgtacgcgc
    13141 cgtcgggcag gtcttcgagg tccgcggggc cggtgaccgc gtccagggct tcgatcagcg
    13201 tctcgcggtc ggtgccgacg gctgcgtacc ggtggtcctc gtgggtgcgc cgggtcgccg
    13261 cggacgcgac gaggtcggtg agcggcacgt cgtcgcggga gagctgctcc cgcatccggg
    13321 cgacctgttc gaccaggcct tccggtcggg gcgcggagac gagcaggacg tgcggcctcc
    13381 cggtggggcc gtcggccggc gcgtcggtcg gtgcctcctg ccgcggcggg gcctcggcga
    13441 tgaggtggac gttggtgccg ctgagcccga aggcgctgac accggcccgc agcgggcgcg
    13501 cggaggccgt ctcctgaccg gaggcttctt gaccggaggc cgtctccctg ccgggggcgg
    13561 tcaggtctgt gccggcgagc gagacggcga tgccgcccgc gtcccagtcg acggccgggg
    13621 tgagctcgtc gatgccgggc tgggccggca cgtgtccggc gccgagaatc cagatcgact
    13681 tgatgaggcc ggtgatgccg gccgcggcgt cggtgtgccc gaagaccgcc ttgtgcgagc
    13741 cgaccaccag cgggagggca tcgccgcgtc ccgctccgta cacctcggac agggtgccga
    13801 gttcgatcat gtccccgagg ggtgtgccgg tgccgtgcgc ctcgacgtag tcgacgccgt
    13861 cggtgcccac gcgggccgcg gccagcgccg accgcaccac ggcggcctgg gcggaggcgt
    13921 tcggggcggt caggccgacg ctgctgccgt cgttgttgac ggcggaaccg cggatgaccg
    13981 cgtggacgcg gtcgccgtcg gcgagcgcgt ccgccagccg cttgaggacc acgacgccgc
    14041 agccctcgcc gcggacgatg ccgtcggcct ccgcgtcgaa ggggcggcag cgcccggacg
    14101 gggaaaacgc gccgatccgg ctcatgaaga cactgatctc ggggctgagc agcaggctga
    14161 cgccgccggc gagggcggtg tcgatgtcgc cggcgcgcag gctctggcac gcctggtgga
    14221 cggcgtacag ggacgacgag catgccgagt tgaccgcgac ggcggggccg cgcaggtcga
    14281 aggtgtaggc cagccggccc gcggcgaagc tgaactccat gccggtgatg tagtgcgggc
    14341 tgacgccctg cgggccgagc gacttggcgt gcagcaggtg gtagtcgttg gcgagcagac
    14401 cgacgtagac gccggtgcgg gtgccgcgcc agtcttggcg cgcccggccg gagtcggcca
    14461 tcgcctcgga ggcgacctcc atcagcaggc gctgctgggg gtcgatggcg gccgcctcgc
    14521 ggggtgtgat gccgaagtag ggcgcgtcga accggtcgac gtcctccagg aaggcgccga
    14581 cgtgatgggt gatggtgccg ggggcgtcct gctcggcggc gtcgtgcagg tcccgtcccc
    14641 agcggtcctc ggggacctct tcgaggacgg tgccgccgga cctgagcatc ctgccgagcg
    14701 agccgaggtc acgtacgccg cccgggaggc ggcaccccac gccgacgacg gcgatgggct
    14761 ctgcgggagg gaaggtcacg tccgggctgg cgaccatggg ctcgacacgc ctttcggctc
    14821 ggtggggcgg ggcggctcgg cggacgggag gcccgccgga gcgagggtca ggcgccggcg
    14881 cgggccagac gggtcaccat cgcggtgatg ctgcgtacgt cgcggaggtt gtccgggttg
    14941 atctccatcg cggacaccgg gacgccgagg tcactgcgga tgaacgcgat cagccgcgcc
    15001 acgcgcaggg agttgaggac gccccactcc aacaggggtg atccgggttc gagttcgccc
    15061 tgcggatccc cgtcgaggaa ccgctcgcgg atgaactcgg tgatgcgttt cgacgtctct
    15121 tcctcggaca cgggctggga catggcgtca cctttctcgc tgacttggct gggctcccga
    15181 ggggcggggt gtcctcactg cgcggcggcg cccggggccg gggcttcggc cgtgtcccgc
    15241 agcgccaggc ggtcgacctt cccgttgcgg gtgcggggca gcccgggcag tacgcgcacc
    15301 tcgtcggcga ccatgtagcg cggcagccgc tgcgccgcgt gccgtacgag cgagagcact
    15361 ccgggacggc ggtccggctc gggcaccacg aacgccacca gccggccgtc catgccgctg
    15421 cccacgacca cggcggccgc ctccgcgacg tccgggtgca gtgcgagcac ggactcgacc
    15481 tcgcccagtt cgacccggtg gccgcgcact ttgaccatgt gatcgcggcg gccgaggtag
    15541 gcgaacgatc cgtcgggcag cgggcggacc aggtcgccgg tgcggtaggg gccggtgtgc
    15601 ggttccctgc cccagtagcc gagcatcacc gtcggcccgt cgacgagcag ttcgccctcc
    15661 tcgccgggtg cggcgagccg cccgtccggg ccctcggccc aggcccggtc gccgctgacg
    15721 gcggtgccga tgggcagggg ccggtcgccg tcgaggtcgg tggggcggac ctcgtggcgg
    15781 gtacagacgt tggtctcggt gggcccgtag aggttgagca gccgggcgtc ggtccaaccc
    15841 gccagcgcgc ggacgcccgg gagggggaag ggctccccgg cgaagagcac ggtccgcagc
    15901 gctcgggggg cggggcggtc cagcagtccc ccgtcacgca tcatcagcgt gagggcggac
    15961 ggcaccgagt accagaccgt gatctgccgg tcgtgcagga actccaccaa ctgttccggt
    16021 gcgtaggcga gttcggaggg aatcaggtgc accgacgcgc cggccgagaa cgcggcgtac
    16081 aggtccagga cggacaggtc gaaggtgaac ggggcatggt tggagaagcg atcctgcggc
    16141 ccgggggcga gctcctcgac cgcccagtcg acgaaggcgc gcgcgttgcg gtggctgatg
    16201 cacacccctt tgggagcacc ggtcgatccg gaggtgtaga ggatgtacgc caggtcgtcg
    16261 ggcgccacca gcgcgttgag gggttcggcg gccgggtcgg gccgctgggc gaggtcggcg
    16321 gccggacacc gcgggccgag cacgtcggcg accggcgcca gacggtcggc cggggccagg
    16381 agcgcggcgg ccgagcagtc gtcggccatg gcggcgaccc gggcgatcgg cagggcgccg
    16441 tcggcgggca cgtaggcggc gccgaggcgg agcaccgcct gcatcgcggc cacgacggcc
    16501 ggcgacttgt ccgaccacag cacgacccgg tcaccgggcc cgacgcccag ggcgcgcagc
    16561 cggtgggcga gggcgttggc ggtggagtcg agctccccgt aggtcagtcg ggcggcggtt
    16621 ccggccacgg ccagccggtc gggttccttc gcggcggtgt cgacgaggag ctggtggagg
    16681 ttcacaggcc gatctccctc gcgacgatct cgcgctgaat gtccgtggtc cccgagaaga
    16741 tcgtgctggg tacggcgtcg cggagctgct gttcgatccc ggcggggctc agatagccgg
    16801 aacccccgaa gatctggatc gcgtcgaggc tgttggccac cgcgccctcc gagacggccg
    16861 tcttggacag ggcgaccgcc gtgctgtggt cacgcccctg gtccatgagc cagcaggcgc
    16921 ggtacagcag cagccgggcg gcctccagcc gctgcttcat gccgacgacg cggtgcgaga
    16981 cggcctggaa ctcgccgatg ccgtggccga actggcgccg ttcgcgggca tgtcgcacgc
    17041 actgctccag ctggcgttcc atcaggccga ggtagccggc gaacaggatg gcgcgttccc
    17101 agcccatcga gtgctggaag atgatgctcc cctggccctc ggtgccgagc cggtgggagg
    17161 tggggacgtg gcagtcgcgg aaggcgaccc ggccggcggg gcagccgctg agccccatct
    17221 tgcggaaggg ctcaccgact tggacaccgg gcaggtcggc gcgcagcacg aaggccgtga
    17281 ccccgaggaa tcccgctgcg gggtcgctcg tgccgtaggt gacgagcaca tcggcggccg
    17341 gggcgttgct ggcgaacgac ttctccccgt tcagcaggta tccgtcgtcc ttccgctccg
    17401 cggtgacggc gagacggctc aggtcggaac ccgcgtcgtc ctccgtcatg gcattggcgg
    17461 cgacgagctc tccggacgcc agcccggaca gcagctcccc gcgcaccgag acgtcggcga
    17521 agtcgcggat cgggacggca caggccagca gatgggcgga aacggcgaac accagcccgg
    17581 tgtcggggca tccccggccg aacgcctcca ggcacagcgc ggtgtccagc gcaccgagac
    17641 cgccgcctcc gaactcggtc ggcaggcaca ggccggtcag gccgatccgt gccgcgtcct
    17701 gccatcgggc aggggtgaac ggctcgcccg aggggggctc gccgagccgc tcccgcactg
    17761 cggacaagac gtcgtcatag cgttgccgct gtttttcggt gaggtcgaaa tccacggaaa
    17821 gccgtacctc gcgtcggatg agaagaagcc ttgccgtttc cgatcggcac gttactctcg
    17881 gcccaccggg acgagtcatc ccctaccgga ggcccctatt tcccctatcc ggggccgggg
    17941 cgcgcacgtt accgtggggt tgcccatcga gtggggccgc gagtacgttg cggtgaacgg
    18001 ggcgatactc cgccgacctc ttctcggcct tcctgtcggc aagctctgcg tacttcccgg
    18061 ctgctgtcgc ctcggtcagc tcttctcggt tcttcttcag acgggacgga ttcgcgatgg
    18121 ctcatcagcc ttcggacaca atcgccggcc tttacgaggc gttcaattcc ggcgacctgg
    18181 aaaccctgcg ggagctcatc gccccggacg ccgtcattca tctgcccggg acggcgggcg
    18241 acgccgaaca cccgccgggc accccccgcg accgcgaggg gtggctgggc gtgtggcagt
    18301 tcacccaggc gttcttcccg gacatgaccg cgaccgtgca ggacatcgtg cagaccggcg
    18361 acttggtggc cacgcggtgc gtcgcacggg gaacgcactc catcgagttc atgggggtcc
    18421 cgccgaccgg ccggcccttc gagatgacga tgctcaacat gagccgggta cgggacggcc
    18481 ggatcgtcga gcactggacg atcagtgaca atgtcaccat gctcgcgcaa ctcggcgtga
    18541 aggcgtccct gtgaaggcgt ccctgtgaag gcgtccctgt gaaggcgtcc tcggtgaagg
    18601 cgtccccgtc ggtgagggcg tctcggtagg ggttacccct aaggggtgtg gatcgcgggc
    18661 atcgcagccg cgatccgcac ttccctcagt cacgtcacag atcgaccggt atctcctggc
    18721 gtcgcgttat ccggagtttc tggtatatcc gcgtgagatg ctgctcgacg gtactgacgg
    18781 ttatatacag ttgctgggat atctcgcgat tggtgtgacc gtaggacgcc agcgaggcca
    18841 cccggtactc cgcttcggtc agatccactc cgggtttcgg ttcggttcgc accgagccgg
    18901 attccgaatc cgcggcgacc atcctgttcc gtccgccggc ggccatgcgc cggtacagcg
    18961 gatccgcccc gcattctgcg gcgagatgcc ggcccttgcg cctgaccaga tccgcgcggg
    19021 tctggttgcc cagcgcctca tgcgcctcac tgaggtcggc cagcgccttg gccagttcca
    19081 gccggtcatt gcctgcgtcg aactcctcga cggcccgacc gagcagctgt acgcggtcgg
    19141 tcagcggcgc gatcgcggcc tgcagcctca gggtgatccc ccgaagccgg ccgtacccgg
    19201 ggaactcctg gctgacttcg gcgtcgagca gctgctgggc ctgggacggc tccccgagct
    19261 ggagccacgc ctgggccgcg tcggtgcgcc acgacaccag catggggtgg tcgatccccc
    19321 agctgcccgc caggttcccg attctcagga agtccgacag agcggcatgc gagcggttcg
    19381 tcgccagatg gaagtgcccc cgcgcccgca ggtagccgag ccagtacacg ctgtcgaacc
    19441 agtcctggga gaccggctgg tcgagcaggc gtaccgcggc gtcgtagcgc cccatctcgg
    19501 tgtatgccag ggccaggatg gaggaggtac cacagaccag cacgctgccg ttgcgctcgg
    19561 ggaccacttc cagcgccatg gacgcgctgg cgacggcctc ctccaacttg ccctgccgca
    19621 gcgcgatcat cccctggacg acggccaaca ccccctgcca gcccgggatg ttgcggcggg
    19681 tggcctcgtc caggatcttc gcgcaccact gcgccgccgc ctcgacctgg tcggagtaga
    19741 gcagcgcctt gagcgcgctg cacaccgggg ccaccatcga gtcggtgagg gagcacatct
    19801 ccaggaaact ctccgcggac ccgctccagt cctgcgcggc gatgagcacg tcctccgcgg
    19861 acttccgcag cagcggtatg ccggggacgg aaccgttgac cagggagccg gggtcggagg
    19921 ccggcccctg cgccgcgccg ccgcgctggc cgctgtcggg gaagtccacg ccgtggaacc
    19981 cgtagcgcac ccacatcgag gcgatggtgg ggtggatgcc ggggacgggc cggggcacgt
    20041 cgcacgacgc gtcctcgctc agccggagga cctccatcgc ctccactatg cggccgtgcg
    20101 cggacagcag cttgccgagc atgccgagac tggtcggcga cagctcgccc cgccgcatgg
    20161 cgctgaggag ttcagggaga tggcggtact ccgcggccgc ggggttggtg cgccaggtga
    20221 tcagcgccag ccgcatcttg atctcgatcc gctggaccgg gtcagggcag gcctcatgag
    20281 ccagttcgag acagtcgatg gccaggacgg catcgtcctc ggcgagtgcc tcctcggcgg
    20341 cgttgcgcag cgcgatgagc tcccagggct gggcggcgct gcgcgctttg agcaggtggc
    20401 gcgcgaccac cgacgccgga tatccggcgg agtgcagggc cacggccacc caggagtgca
    20461 gggcggtacg gcggtcgggc gccaggtcgg ccaggacggt cgcgacggcg gcctggtgcc
    20521 ggaacgcggt gcccgcgatc atgccggccg cggtgagggc ctggaggttc tggtcgatca
    20581 gcgccgaggg ctggtcgacc agcctgggca ggatcgcgtg ggccctcggc tcgtccagga
    20641 cggcgagcgc gtgccccagc tccagggcgg ccggaccact gcggtacagg ctggcgagga
    20701 ccgcctgtcc gtagagtccg ccctccatgg gctcgatctt gtccgcgatc ccggagtctg
    20761 cggtggcggg acggcattcc tccagcagcg cccgcaggag cagcgggttt ccggcggtga
    20821 tgaagtgcag ccggtccacg aggggacggt cctgcgcgtc gccgccctgc gcggcgagca
    20881 gcgcggcggt gccctgcttg gtcagcggac ccagccggat ccgcagtgag ttggactgcc
    20941 gcagcagctc cgtcttgatc accgggtccc ggcgcgggag gtgcaggctg tccccgaaca
    21001 cgaggaggat ccgggcggac cgggtgaagc ccgccgcttg caacaagtgg tgaagcgacc
    21061 ggctgtcgcc gtactgcgcg tcgtccacac agacgaccac ggggctccgg ctcgccagcc
    21121 ggtggagggc ctcgccgaac tcctgctccc cgacgccggg ttcggaggga acccagcccg
    21181 gcacctgccc cagtaactgg cgtagcaggg cgaggggctg atcggatgcg gagcgtatgc
    21241 ccatccctct gaggaccgcc gccccctgtt cggtggcata ttccgtgaac gtgtccagca
    21301 actcgctctt gccgcagccc acgccgcctt ccacgacgat catcttggcc cgcccggctg
    21361 cgcattccgc gagtccggac ttcagtagcc caagttccgc ttcacgattg accagtatca
    21421 tccttgttgg acaccccgtg agttcacata aatttacgcg ctcaagggca gggctgcgct
    21481 gaggtcgccg accgatcagg caggtgaaca tcccgcagtc tccatgacgg gtcaaaagtc
    21541 cacatcatga gaggagcggt aacatgtcgg cgcgcttgcc cgtcggacat tttttgacgg
    21601 gacatcagct attcgggcgg gggaaatcca cgtgccccag gcctgtatct cgatgtcccc
    21661 acagagactg attgagccaa gagtgcatca ttgcccccgt atcgcaaccc tgacactcgc
    21721 tgtcggcccc agggtagcgt cttgaacgac catgcgcgag gccccctctc cagccacacc
    21781 gcttacacgg caccagcttg cacagggggc gggaccaccg ccccgccggc cggaaagcga
    21841 ccgtgcacag cccttcctac ctgcgcttga gcctcgatcc gcgctccgtc ggcgtgcggc
    21901 ctggccgatg cgcgacaacg taccagggcg atcttttccg gccgttgtgc ttccggcgtc
    21961 ggccatatcc ggccaacgcc ggggatcacg tcgagcaccc cccttagtca ccccctatct
    22021 ccccctcggt gtaccccgta ccacccgtct tcgacttccc gtcaccacgg gtgcacggca
    22081 atcgtccggc gccccacgcc gtattgcggg gtcgcggaat cgtgtcgcgg tacgaccggt
    22141 ccggcggtcg gcgagccacg acgcagtgcg actcctcgag acacccctag gccgcctgcc
    22201 ccgaagtgct tcccctatgt catttcccct cgcacgtgta ggggttgtcc ggttccgttc
    22261 gcgctcacta gcgtgacgca gacccgtact ctcgccgagg gccgacgcgt ccgccgggaa
    22321 ggcgggagtc ctactcatca gtgcaactct tcggccactg tggggaaacg cgtggaagaa
    22381 atcatcagcg ccattcttgc cgacggcacg acgagcgagg acatctccgg cctgcgaata
    22441 ccggacacct atcgcgccgt caccatccgg aaggacgaaa tcggtctctt cgaagggatg
    22501 gcgtcggccg acaaggaccc ccgtaagtcg ttgcatctcg acgaggtacc ggtgcccgaa
    22561 ctgggcccgg gtgaggctct ggtggccgtg atggcctcct cggtcaacta caactccgtg
    22621 tggacctcga tcttcgagcc gctgcccacc tttcacttcc tgaagcgata cggcgcgacg
    22681 tccgccatgg ccgcccgcca cgatctgccg taccacgtca tcggttccga cctggcgggc
    22741 gtggtcctgc gcaccggtcc gggcgtcaac gcctggaagc cgggcgacga ggtcgtggcg
    22801 ca
//
