LOCUS NZ_LMEQ01000016 27737 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_23, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000016 VERSION NZ_LMEQ01000016.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 27737) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 27737) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 27737 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000016.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..27737 /candidate_cluster_numbers="1" /candidate_cluster_numbers="2" /candidate_cluster_numbers="3" /candidate_cluster_numbers="4" /contig_edge="True" /product="terpene-precursor" /product="phenazine" /product="T3PKS" /region_number="1" /rules="(PT_FPPS_like and not PT_HPP)" /rules="phzB" /rules="(Chal_sti_synt_C or Chal_sti_synt_N)" /tool="antismash" gene <1..98 /locus_tag="ASD48_RS42315" source 1..27737 /collection_date="2012" /country="Germany: Cologne" /db_xref="taxon:1736452" /host="Arabidopsis thaliana" /isolation_source="root" /lat_lon="50.958 N 6.856 E" /mol_type="genomic DNA" /organism="Streptomyces sp. Root1310" /strain="Root1310" /submitter_seqid="contig_23" cand_cluster 1..27737 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(PT_FPPS_like and not PT_HPP)" /detection_rules="phzB" /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)" /kind="neighbouring" /product="terpene-precursor" /product="phenazine" /product="T3PKS" /protoclusters="1" /protoclusters="2" /protoclusters="3" /tool="antismash" cand_cluster 1..19557 /candidate_cluster_number="2" /contig_edge="True" /detection_rules="(PT_FPPS_like and not PT_HPP)" /kind="single" /product="terpene-precursor" /protoclusters="1" /tool="antismash" protocluster 1..19557 /aStool="rule-based-clusters" /category="terpene" /contig_edge="True" /core_location="[8474:9557](-)" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" /tool="antismash" proto_core complement(8475..9557) /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="(PT_FPPS_like and not PT_HPP)" /neighbourhood="10000" /product="terpene-precursor" /protocluster_number="1" cand_cluster 1..18032 /candidate_cluster_number="3" /contig_edge="True" /detection_rules="phzB" /kind="single" /product="phenazine" /protoclusters="2" /tool="antismash" protocluster 1..18032 /aStool="rule-based-clusters" /category="other" /contig_edge="True" /core_location="[164:8032](-)" /cutoff="20000" /detection_rule="phzB" /neighbourhood="10000" /product="phenazine" /protocluster_number="2" /tool="antismash" proto_core complement(165..8032) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="phzB" /neighbourhood="10000" /product="phenazine" /protocluster_number="2" CDS <5..98 /codon_start=3 /inference="COORDINATES: protein motif:HMM:NF020130.4" /locus_tag="ASD48_RS42315" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /product="3-oxoacyl-[acyl-carrier-protein] synthase III C-terminal domain-containing protein" /protein_id="WP_157880679.1" /transl_table=11 /translation="AHRNHALHPGDLVLLAGFGGGMAAGLALIEW" gene complement(165..632) /locus_tag="ASD48_RS23770" /old_locus_tag="ASD48_40765" CDS complement(165..632) /GO_process="GO:0017000 - antibiotic biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) phenazine: phzB" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132912.1" /locus_tag="ASD48_RS23770" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40765" /product="PhzA/PhzB family protein" /protein_id="WP_057603730.1" /sec_met_domain="phzB (E-value: 1.4e-51, bitscore: 166.0, seeds: 33, tool: rule-based-clusters)" /transl_table=11 /translation="MFTDHHDLRARNRRAVEQYMRTGAEARLSRYTLYTQDGTASLFYT DIGRPIVVTGREKLKRHGELSLRVLPDWQWSDVRIYETQDPSTIMVECGGEGTIRFPGY REGRYRNHFIHGFTLHDGRIAASREYTNPIEHMKSLGIETPHIRRDWIPSS" gene complement(710..1411) /gene="phzG" /locus_tag="ASD48_RS23775" /old_locus_tag="ASD48_40770" CDS complement(710..1411) /EC_number="1.10.3.16" /GO_function="GO:0016682 - oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Evidence IEA]" /codon_start=1 /gene="phzG" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132913.1" /locus_tag="ASD48_RS23775" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40770" /product="phenazine biosynthesis FMN-dependent oxidase PhzG" /protein_id="WP_079073946.1" /transl_table=11 /translation="MSDLSSSRSANGTAVAARRGSTRSETLTGALHVPFPEFIAPPAEP MGLLSAWLDAAVGHGVREPRALALATADARGRASSRIVALTKVTGAGIVFITHAGSRKG RELAENPWASGVLYWRETTQQITLAGPVTRLSDAEAEDLWRARAVFTHAMTTVSRQSVP VDNLDHFARLRSEALRLGEPLRPLPRPATFAGYLLEPASVEFWANGTDRLHERLHYERT DGGWEISRLQP" gene complement(1404..2243) /locus_tag="ASD48_RS23780" /old_locus_tag="ASD48_40775" CDS complement(1404..2243) /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /GO_process="GO:0009058 - biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132914.1" /locus_tag="ASD48_RS23780" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40775" /product="PhzF family phenazine biosynthesis isomerase" /protein_id="WP_057603731.1" /transl_table=11 /translation="MHTYVVVDAFAREPLTGNPVAVFFGADDLSAEQMQRIAREMNLSE TTFVHRPRQDGTDAHVRIFTPVNELPFAGHPLLGTAIALGRRTDADRLRIETAMGVVPF ELERAHGQVVATSMMQPVPVWEPFDRTDELLEALGLHRSTLPVEIYRNGPRHVLVGLES IEALSKVDPDHRALARFPDMATNCYAGQGSSWRNRMFSPAYGVVEDAATGSAAGPIAIH LARHGLIPYGQRIEIIQGVEIGRPSPMRALAHGEGDHVTSVEVAGPGVVTIEGVLHV" gene complement(2342..4264) /locus_tag="ASD48_RS23785" /old_locus_tag="ASD48_40780" CDS complement(2342..4264) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1018: isochorismate synthase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132915.1" /locus_tag="ASD48_RS23785" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40780" /product="anthranilate synthase family protein" /protein_id="WP_057603732.1" /transl_table=11 /translation="MTHGPHTNPGDLLAQALAGPATRPYALLHRPGATGPGIVEVLTGE VSLPATLADIELPESPADGIGAHHQVLVVLPYRQLAERGFACADDGTPLVAMTVTGQQR LPIEEALARIPDVPTPLAGGDFDVDDAAYEDVVRRIVKEMIGTGEGANFVIKRTFVADI TDYGPRSAPALFRRLLTRESGAHWTFLIHTGTRTLVGASPERHVSLQGGTAVMNPISGT YRYPTSGPTLSGVLEFLGDRKETDELYMVLDEELKMMARICPGDGRVVGPYLKEMAKVA HTEYFIEGRTDRDVRDILHQTMFAPTVTGSPLQSACRIIAQYEPGGRGYYSGVAALIGQ DAHGERVMDSAILIRTADISTHGRIGIGVGATIVRHSDPASEAAETHAKAAALVSALGG TQDTERFADHPVVRQALGLRNASIADFWLTDAEARTAARPELAGRSVLVVDAEDTFTSM LGQQLQSLGLHVTVRRFDEPYSFDGHDLVVMGPGPGDPQELAHPKMRHLHTAVDTLLRE GRPFFAVCLSHQVLGLRLGLPLRRRPVPNQGVQKRIDLFGSAERVGFYNTFALLTEHDE FVADGVGPVRVSRDAATGEVHALSGPGFASLQFHPESVLTREGPRIVGTRLAALLTPAQ AAHRA" misc_feature complement(4395..4409) /note="TFBS match to SypG, Regulator of biofilm formation and host colonization, confidence: weak, score: 17.32" /tool="antismash" gene 4426..5676 /locus_tag="ASD48_RS23790" /old_locus_tag="ASD48_40785" CDS 4426..5676 /codon_start=1 /gene_functions="other (smcogs) SMCOG1192: transposase" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005474521.1" /locus_tag="ASD48_RS23790" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40785" /product="RNA-guided endonuclease TnpB family protein" /protein_id="WP_057603733.1" /transl_table=11 /translation="MMQQVRRAFKYRFYPTDEQAAELSRTFGCVRLVYNKALEERTRAW YGERCRISYVQSSAALTQWKKTEGLAFLSEVSSVPLQQALRHLQAAFGNFFAKRAKYPR YKSRKKSRASAEYTRSAFTWRDGRLTLARMAGALDVRWSRPLPQGAQPTTVTVSRDAAG RWFVSMLVEDPIAFAPATNAAVGIDAGITSLVTLSTGEKIANPQHERRDRARLAKAQRE LSRKAKGSANREKARRRVARVHARIADRRRDFLHQLSTRLVRENQTVVIEDLTVRNLLK NGRLARAISDAAWTDLRMMLEYKCAWYGRELVVIDRWFPSSKLCGNCGTVRGRLPLNVR EWTCDSCGTVHDRDVNASRNILAAGLAASACGDGVRPQRESSRTGRSSVKQEPQRATAG LPRLKAGEEVKRTPPSR" misc_feature complement(4447..4458) /note="TFBS match to AfsR, Pleiotropic regulatory for antibiotic production, confidence: medium, score: 19.28" /tool="antismash" gene complement(5651..6274) /locus_tag="ASD48_RS23795" /old_locus_tag="ASD48_40790" CDS complement(5651..6274) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1027: isochorismatase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006377041.1" /locus_tag="ASD48_RS23795" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40790" /product="isochorismatase family protein" /protein_id="WP_057603734.1" /transl_table=11 /translation="MTGIPPITAYPLPAEGDLPAALVSWKADADRSVLLVHDMQRYFLK PFPDSLRDDLIRNAAHLRDRCAELGVPVAYTAQPGGMTDEQRGLLKDFWGPGMRTSPED RQVVDALAPAGHDWLLTKWRYSAFFKTDLLQRMRAAGRDQLVLCGVYAHVGVLATAVEA FTHDIQPFFVADATADFSQEYHRSALTYAAERCARVITAKEVFV" cand_cluster 6293..27737 /candidate_cluster_number="4" /contig_edge="True" /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)" /kind="single" /product="T3PKS" /protoclusters="3" /tool="antismash" protocluster 6293..27737 /aStool="rule-based-clusters" /category="PKS" /contig_edge="True" /core_location="[26292:27462](+)" /cutoff="20000" /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)" /neighbourhood="20000" /product="T3PKS" /protocluster_number="3" /tool="antismash" proto_core 26293..27462 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)" /neighbourhood="20000" /product="T3PKS" /protocluster_number="3" gene complement(6310..7497) /locus_tag="ASD48_RS23800" /old_locus_tag="ASD48_40795" CDS complement(6310..7497) /EC_number="2.5.1.54" /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IEA]" /GO_process="GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018554464.1" /locus_tag="ASD48_RS23800" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40795" /product="3-deoxy-7-phosphoheptulonate synthase" /protein_id="WP_079073947.1" /transl_table=11 /translation="MNEVVKDAIRDIRVRGALQQPEWSDLLQLSRVTEALASRPTLVQP DDVATMRTQLGSVALGQALVVQSGDCAEDPQECGPHHVARKAAVLDLLAGALGLITGKP VLRAGRIAGQFAKPRSKPTEDVDGVELPSFKGHMVNAPEPDPESRRADPLRILTGYMAA SDVIDHLGWRERGAGRDVVGPPVWTSHEALLLDYEMPLLRLDEQGRLFLGSTHWPWIGE RTRQVDGAHIAMLSQVSNPVACKVGPSMEPEELLALCERLDPWRDPGKLTLIARMGAAN VADRLPRLVEAVREAGHPVIWLTDPVHGNTVTAPSGHKTRLVETVALEVSRFVTAVRDA GGVPGGLHLETTPDDVTECAGTEADLATVGERYTSFCDPRLTPWQAVSVISSWTA" gene complement(7544..8032) /locus_tag="ASD48_RS23805" /old_locus_tag="ASD48_40800" CDS complement(7544..8032) /GO_process="GO:0017000 - antibiotic biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) phenazine: phzB" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132918.1" /locus_tag="ASD48_RS23805" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40800" /product="PhzA/PhzB family protein" /protein_id="WP_057603735.1" /sec_met_domain="phzB (E-value: 1.2e-76, bitscore: 248.4, seeds: 33, tool: rule-based-clusters)" /transl_table=11 /translation="MPESVDTKEFTDESETRRHNRAVVEQYMNTTGQDRLRRHELFTED GVGGLWTTDTGSPVATHGRDRLGEHAVWSLACFPDWEWYNVRIFATDDPDHFWVECDGH GTIRFGDYPEGYYENHFLHSFEFENGKIKRQREFMNPFQQLRALGIPVPEIKRTGIPT" misc_feature complement(8367..8381) /note="TFBS match to SypG, Regulator of biofilm formation and host colonization, confidence: weak, score: 16.89" /tool="antismash" misc_feature complement(8372..8392) /note="TFBS match to NrtR, NAD synthesis repressor, confidence: weak, score: 20.06" /tool="antismash" misc_feature complement(8415..8430) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 16.38" /tool="antismash" gene complement(8475..9557) /locus_tag="ASD48_RS23810" /old_locus_tag="ASD48_40805" CDS complement(8475..9557) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene-precursor: PT_FPPS_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182: Polyprenyl synthetase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004923101.1" /locus_tag="ASD48_RS23810" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40805" /product="polyprenyl synthetase family protein" /protein_id="WP_057603736.1" /sec_met_domain="PT_FPPS_like (E-value: 8.6e-49, bitscore: 156.8, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MTTSTRTSPVEVVEDALRQFFAARRDEAAAIGPACADAVAELETY VLRGGKRVRPTFAWLGWLGAGGEAQDATAPAVVRVCAALELFHASALIHDDVVDASPTR RGAPAAHVMFADRHRRQCWNGNAELFGTGAAILTGDLAQGWADDLIHTCGLPAPALARV SPVWSALRNEVLFGQLLDVTAEAAGDEDIATPLRVNQYKTASYTVERPLHLGAAIAGAD AALVDAYRAFGRDIGVAFQLRDDLLGVFGTPEETGKPSGGDLVQGKRTMLFAAALGYAD ERDPDAAKFLRAKIGTPVSDDELAAMRAVITDVGAVDHIERDITRRTDRALAALRESSA TEDAKEELTAMAISATQRTS" gene 10154..10915 /locus_tag="ASD48_RS23815" /old_locus_tag="ASD48_40810" CDS 10154..10915 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0016987 - sigma factor activity [Evidence IEA]" /GO_process="GO:0006352 - DNA-templated transcription initiation [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1032: RNA polymerase, sigma-24 subunit, ECF subfamily" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016570765.1" /locus_tag="ASD48_RS23815" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40810" /product="sigma factor-like helix-turn-helix DNA-binding protein" /protein_id="WP_057603737.1" /transl_table=11 /translation="MIKAEEFARLRPLLFAIAYRIVGDERTARYAVQAAWLRWMAAPAR PEPAEGYLAAEVTRVAAGALRSARAERGELVAPLLGEGPREAGRPAQLADSLSLSALLV LERLSPLERAVFVLHEAFGCDEAQIASALGCSREACGQLLAAVAAVSDGGREPLPWPTC VEGAGNAARMIAAIVPPLVRVGVTLEESRVGDRPGWVFRDRDGAVLHTMVADVVDGRVQ RVHLVVHPGGHRHAGPVAEACALLREANRAR" gene complement(10987..11349) /locus_tag="ASD48_RS23820" /old_locus_tag="ASD48_40815" CDS complement(10987..11349) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008403811.1" /locus_tag="ASD48_RS23820" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40815" /product="DUF3099 domain-containing protein" /protein_id="WP_057603738.1" /transl_table=11 /translation="MSRSPWHREGTRADSITGARIGLTQDLRGRQRRYVTAMLVRSACV VVMALTWSRWPAVAVCALAGGVVIPYVAVVAAQAGWRQQRGVRAELARPDPDPVPVPRV VLEPTLILPPERDTAG" misc_feature complement(11398..11412) /note="TFBS match to CelR, Cellobiose uptake repressor, confidence: weak, score: 22.2" /tool="antismash" misc_feature 11399..11413 /note="TFBS match to CelR, Cellobiose uptake repressor, confidence: weak, score: 22.1" /tool="antismash" gene complement(11524..13275) /locus_tag="ASD48_RS23825" /old_locus_tag="ASD48_40820" CDS complement(11524..13275) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020133217.1" /locus_tag="ASD48_RS23825" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40820" /product="ubiquinol-cytochrome c reductase cytochrome b subunit" /protein_id="WP_057603739.1" /transl_table=11 /translation="MSTTEEAPQGARTIPSKGERVADWADGRLGIYSLRFLIRKVFPDH WSFMIGEIALYSFIVLILTGVWLTMFFDPSMTETVYDGSYVPLQGIPMSQAYATTIEIS FDVRGGLFIRQLHHWSALIMIGALMMHTLRHFLTGSFRKPREVNWLIGFVILVLVTLEG FVGYSLPDDLLSGTGLRIAEGVTLAIPVVGTYLTLFLFGGEYPGHDVIPRFYSIHILLI PGIVLALVALHLLLVFYHKHTQFRGPGRTNNNVVGQPLMPHYTAKAGGFFFLVSGLLAL LAGIAQINPVWTYGPYRSDQISQGSQPDWYMGFLEGALRAMPAWEFVLPGGYTVNMSVL LPAVILPGVMMVVFAMWPFLEAWGTGDKREHHLLDRPREKPTRTAFGLAFVSFYLVLFF GGANDVLAERFHLSLNSITWAVRVGLVVVPLLVYVITKRICLGLQRRDRDKLLHGRETG RIKRLPHGEFVEVHERIDRGLEYKLLSREIPEVLPAPEPADGDGVPDPDVRRKRRRHRL SRWLYGDEVPTPTLQEMQQALEHLGHAPSSNGHAPSSNGHAPSLNGHPADGEHAAVGER EHDQQVH" gene complement(13616..15133) /locus_tag="ASD48_RS46025" /old_locus_tag="ASD48_40825" CDS complement(13616..15133) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1246: monooxygenase FAD-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF024842.4" /locus_tag="ASD48_RS46025" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40825" /product="NAD-binding protein" /protein_id="WP_157880680.1" /transl_table=11 /translation="MALDARVVGTNGGHGHAVVIGSGLAGLTAARALAGFMDRVTVIER DRLPRGPGRRRGVPQARHTHSLTTAATDGLQRLFPGIRQDLLRAGAVHVRVPEDTLLLG PAGWLPRFDAGLPLLSAGRDLIDATVRDRLRADPKVTFLPEHEVVALQPGPQDTVTGVW ARGRDRKAPDGFAPRRPIAAEFVVDASGRGSRAPQWLAEAGYAPPDESAAAAATTYATT LYAPPVGHVADFKSLMHMAAPGDPRQAVLHPVEGGRWSVTIGAGDGTRPPADHAELLHA AGTLREPLLRDLIEAATPLGPVYTCRTESRWRHYEKLRSFPDQFLVVGDALAPLDPAHG HGMTFAVECALVLDHLLTAHGTAVGIGYRLRRALAHRIAPAWRSSTGPLGPPGGLRGRL GARYASRLAAAATADRHAATMLLAARESLDPPAALRPRALRAALRPPAAAPATPPTATH APDARRRRPAGPTAPVIGVSAGSTAPRPAGSSAHWPAAAPAGDRRRP" gene complement(15590..17032) /gene="pcaB" /locus_tag="ASD48_RS23835" /old_locus_tag="ASD48_40830" CDS complement(15590..17032) /EC_number="5.5.1.2" /GO_function="GO:0047472 - 3-carboxy-cis,cis-muconate cycloisomerase activity [Evidence IEA]" /codon_start=1 /gene="pcaB" /gene_functions="biosynthetic-additional (smcogs) SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004941784.1" /locus_tag="ASD48_RS23835" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40830" /product="3-carboxy-cis,cis-muconate cycloisomerase" /protein_id="WP_057603741.1" /transl_table=11 /translation="MTSLYEDQRTHVLGTHLDAGLLSPVRAGTPAEAAVGDRAWLQAML DAEAGLARAQARCGTVPAQAAAAITAAARADLLDVRELALAARETANPVVGLVKAFTAV VAERSPQAAEYVHRGSTSQDVFDTGAMLVAQRALRLIVADLRAVADALAALAAAHRDTV MAGRTLALHAVPTTFGLKAAGWHALVLDAVERLERLTRGGLPVALGGAAGTLAGYLQYA GEGADPARVLDSLSAAFADETGLAVPVLPWHALRTPVADLGTALAHTTGALGKIAADVL VLTRTEIGEVAEPAVAGRGASSAMPHKRNPVLATLIRSAALQVPALATVLLQCLPTEDE RSAGMWHAEWQPLREALRLTGGAAHTAVELARGLAVHPERMRVNLQATGGRLVSERVSA VLAPRMGRTAAKELLTQASVLASRTGLPLGDILAELPQLAGVLSREEVTALLDPAGYTG VAGPLVDRALTTAPERTRTPSP" gene complement(17029..19017) /locus_tag="ASD48_RS23840" /old_locus_tag="ASD48_40835" CDS complement(17029..19017) /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) NpaA" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018841549.1" /locus_tag="ASD48_RS23840" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40835" /product="FAD/NAD(P)-binding protein" /protein_id="WP_057603742.1" /sec_met_domain="NpaA (E-value: 4.3e-247, bitscore: 812.1, seeds: 8, tool: rule-based-clusters)" /transl_table=11 /translation="MTHVQICLVGAGPRGLSVLERLCAQERKSPRWDAVTVHVVDPDPP GAGRVWRPTQSRHLLMNTVSSQVTVYTDASVRIDGPLDEGPSLYQWAKALTSGTLEPDA ECRYHHDVLAEADRLGPDSYPTRALYGCYLTWAFRRVVAGAAAHVRVRTHAVRAVALDD EAGQTGPQTVVLEDGTRLTGLSAVVLAQGHVPVEPCGTQSEMSAYAERHGLTYLAPANP ADVDLSGIGPGEPVLLRGLGLNFFDYLALFTHGRGGDFTRVDGRLVYRPSGREPRLYAG SRRGVPYQARGENEKGAHGRHHPRLLTTDYIAGLRRRSPHRPAIDFAADLWPLITKEVC AVHYAALLAARGEPPSVIEDFTEKYLHAEPGEEEARLLDDSGVTAAERWDWERVARPYD SRALTDRNAFRAWLRGHLDQDVRLARQGNVSGPFKAALDVLRDLRNELRLAVDHAGLSA ESHRDHLDGWYTPLNAYLSIGPPASRIEEMAALLDAGILDVTGPGLRVTTDDDDPLGPC FTATSSEIPGVRVRATVLIEARLPEIDLRRTADPLMSRLLRTGQCRPFRIPGPDGHDGA DYETGGLAVSERPYRLLDAQGTPHPRRFAYGVPTESVHWVTAAGIRPGVGSVTLEDSDA IAAAVLALPELPTAAPQPKTSKARASA" gene 19584..20264 /locus_tag="ASD48_RS23845" /old_locus_tag="ASD48_40840" CDS 19584..20264 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018854643.1" /locus_tag="ASD48_RS23845" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40840" /product="hypothetical protein" /protein_id="WP_242432710.1" /transl_table=11 /translation="MEFMKVAEGGPPHEGDSMMVHPCTRSHDEESRAAAGSLLCAACVA QVERSLRALPGLHQESLHHVSPTPRRTNPTRVSGSLRRDRLNISVLDARHNILATLESW SEIVVEQLRIPAPARSVPQLARFLTRHLAWLAAQPPAADFADEIESLVAELRSTIDPDP GGLSALIRQCVVDDCGGKISASLKSTGNSGSRSIECSAGHSWEMTEWLNLRRLMEQQRK GVTV" gene 20261..20509 /locus_tag="ASD48_RS23850" /old_locus_tag="ASD48_40845" CDS 20261..20509 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132902.1" /locus_tag="ASD48_RS23850" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40845" /product="hypothetical protein" /protein_id="WP_199875928.1" /transl_table=11 /translation="MMKPPRHRLVPTNVAALAVGVSEATIRKWVSRGKITRYGAPNCRS QFDIDELTEIALQRPSRPSPHRHGGGARAAQQASAAR" misc_feature complement(20952..20969) /note="TFBS match to HipB, Bacterial antitoxin HipB, confidence: weak, score: 19.59" /tool="antismash" gene 21024..22013 /gene="mvk" /locus_tag="ASD48_RS23855" /old_locus_tag="ASD48_40850" CDS 21024..22013 /EC_number="2.7.1.36" /GO_function="GO:0004496 - mevalonate kinase activity [Evidence IEA]" /GO_process="GO:0016126 - sterol biosynthetic process [Evidence IEA]" /GO_process="GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]" /codon_start=1 /gene="mvk" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015662655.1" /locus_tag="ASD48_RS23855" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40850" /product="mevalonate kinase" /protein_id="WP_282438262.1" /transl_table=11 /translation="MERVSEDRRARSVGIGRAHAKAILLGEHAVVYGTAALALPIPQLT ATASAGRSSPATDAQGELSFTMTGSASRAVVTRASDGLRRLTAAFKERMGVEDTTHLDV ILDGAIPPGRGLGSSAAHSRAIVLALADLFGLELADSTAFELVQAAENETHGRASGVDT KAVCAAGPLRFQAGEVRELSIGRDGLCIVADSGTAGSTREAVELLRAGFRREAGARDRF LHRAAELVAEAEQALAEGEQEEFGRRLTGYHELMRGAGLSTDRIDAMVGAALKAGSLGA KITGGGLGGCVLAMTQPDQAREVTRQLHEAGAVQTWIVPLRRRVSRAL" gene 22003..23046 /gene="mvaD" /locus_tag="ASD48_RS23860" /old_locus_tag="ASD48_40855" CDS 22003..23046 /EC_number="4.1.1.33" /GO_function="GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IEA]" /GO_process="GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]" /codon_start=1 /gene="mvaD" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132904.1" /locus_tag="ASD48_RS23860" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40855" /product="diphosphomevalonate decarboxylase" /protein_id="WP_057603746.1" /transl_table=11 /translation="MRSEQLLRPRVREGAADATAVAHPNIALIKYWGKSDERLFLPRTD SLSMTLDIFPTTTRVRLAGAAEHDTVTFNGRPATGEAERRIVAFLDLVRERAGVEGRAV VDTENTVPTGAGLASSASGFAALAVAAAAAYGLDLDAAGLSRLARRGSGSASRSVFGGF AVWHAGTTAGTAAQADLSSYAEPVRAAGLDPALVIAVVNAGPKALSSREAMRRTVDTSP LYEPWALSSKADLADMRAALSRGDLPAVGEIAERNALGMHATMLAARPAVRYISPASLT VLDSVLQLRQDGVPAYVTMDAGPNVKVLCRRADAERVAETVRGAAPGGAVHIAGPGPGA RLLSEDG" gene 23043..24140 /locus_tag="ASD48_RS23865" /old_locus_tag="ASD48_40860" CDS 23043..24140 /EC_number="2.7.4.2" /GO_function="GO:0004631 - phosphomevalonate kinase activity [Evidence IEA]" /GO_process="GO:0016126 - sterol biosynthetic process [Evidence IEA]" /GO_process="GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015662657.1" /locus_tag="ASD48_RS23865" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40860" /product="phosphomevalonate kinase" /protein_id="WP_057603747.1" /transl_table=11 /translation="MTTGARTVVRRAPGKLFVAGEYAVVEPGNEAILVAVDRYITATVS AAVEPGTVVISSDLAPRALHRHWRDGRLAGGDGQLPPVESAIETVSDLLAERGLPAPAL HISLSSTLHERGRKYGLGSSGAVTVASVAAVSAYCGLRLTPDERFRLALLACARIDPKG SGGDLAASTWGGWIAYRAPDRARVLDLARSLGVQEALRAPWPGFSVRRLPPPAGLDLQV GWTRSPASTTALVSDLHRRPWRGSASHHRFVQATGGLVRAAVTALEAGDGPGLLREIRR ARQELARLDDEVGLGIFTPALTALCDAAEGVGGAAKPSGAGGGDCGIALLDAGAPHDIS QVRQRWATAGVLPLPVRSAPEGIEE" gene 24137..25231 /gene="fni" /locus_tag="ASD48_RS23870" /old_locus_tag="ASD48_40865" CDS 24137..25231 /EC_number="5.3.3.2" /GO_function="GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IEA]" /GO_process="GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="fni" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_043911621.1" /locus_tag="ASD48_RS23870" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40865" /product="type 2 isopentenyl-diphosphate Delta-isomerase" /protein_id="WP_057603748.1" /transl_table=11 /translation="MSSAQRKDDHVRLAMEQQHAHSGRNQFDDVSFVHHALAGIDRPDV SLATTFAGVAWQAPLYINAMTGGSAKTGAINRDLATAARETGVAIASGSMHAYFKDPSC ADTFRVLRTQNPDGFVIANVNATASVDNARRAIDLIEANALQIHLNTAQETPMPEGDRS FGSWAPQIERIAAAVDVPVIVKEVGNGLSRQTVLALADLGVRAADVSGRGGTDFARIEN GRRELADYAFLHNWGQSTVACLLDAQDAGIPVLASGGVRHPLDVARALALGARAVGSSG GFLRTLVDGGVAALVTQISAWLDQLAALQTMLGARTPAELSRCDLLIHGELRNFCLDRG IDTWRLAQRSSSLDALHEMTGSTR" gene 25228..26289 /locus_tag="ASD48_RS23875" /old_locus_tag="ASD48_40870" CDS 25228..26289 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020132907.1" /locus_tag="ASD48_RS23875" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40870" /product="hydroxymethylglutaryl-CoA reductase" /protein_id="WP_157880681.1" /transl_table=11 /translation="MTEAHAIAGVPMRWVGPLRISGNVADTEIQVPLATYESPLWPSVG RGAKVSRLAEKGIVATLVDERMTRSVLVEATDAQTALTAARTIEARIDELREVVRGCSR FAELIGIRHEINANLLFIRFEFSTGDASGHNMATLASDALLERLLRTVPGISYGSISGN YCTDKKATAINGILGRGKNVVTELLVPRDVVAGVLHTTAAKIVELNIRKNLLGTLLAGG IRSANAHYANMLLAFYLATGQDAANIIEGSQGVVMAEDRDGDLYFACTLPNLIVGTVGN GKGLGFVETNLTRLGCRADGAPGENARRLAVLAAATVLCGELSLLAAQTNPGELMRAHV QLERDNKTAKVGV" gene 26293..27462 /locus_tag="ASD48_RS23880" /old_locus_tag="ASD48_40875" CDS 26293..27462 /EC_number="2.3.3.10" /GO_function="GO:0004421 - hydroxymethylglutaryl-CoA synthase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T3PKS: Chal_sti_synt_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1043: hydroxymethylglutaryl-CoA synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018840867.1" /locus_tag="ASD48_RS23880" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_40875" /product="hydroxymethylglutaryl-CoA synthase" /protein_id="WP_057603750.1" /sec_met_domain="Chal_sti_synt_N (E-value: 3.8e-11, bitscore: 33.6, seeds: 21, tool: rule-based-clusters)" /transl_table=11 /translation="MSLSIGIHDLSFATAEFVLPHTELAAHNGTEIGKYHIGIGQESMS IPGADEDIVTMAAAAAAPVIARHGGDRIRTVVFATESSIDQAKAAGIYVHSLLGLPSAT RVVELKQACYGATAALQFAIGLVRRDPAQQVLVIASDVSKYELDSPGEATQGAAAVAML VGADPALVRIEDPSGLFTADVMDFWRPNYRNEALVDGHESINAYLQAVEGTWKDYTEQG GRALEEFAAFCYHQPFTKMAYKAHRHLLNYCGQDTDNDAVTAALGHTTAYNTVIGNSYT ASVYLALAALLDQADDLTGKAIGFLSYGSGSVAEFFAGTVTAGYRENLRTDANRRAIAR RTPVDLAGYRDLHERSFPTDGGDHATERHTTGPFRLAGISGHKRLYQAR" gene 27598..>27737 /locus_tag="ASD48_RS45425" /pseudo="" CDS 27598..>27737 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020133203.1" /locus_tag="ASD48_RS45425" /note="incomplete; too short partial abutting assembly gap; missing C-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /product="3-oxoacyl-ACP synthase" /pseudo="" /transl_table=11 /translation="MTDVRILGTGAYVPDRIVSNDEVGAPAGVDDAWITAKTAIRERRW A" ORIGIN 1 ccgcccaccg caaccacgcc ctgcaccccg gcgacctcgt cctcctcgcc ggcttcggcg 61 gcggcatggc cgcaggcctc gccctcatcg aatggtgaca gcacgatgcg ggccgccggc 121 cgcgacaggg cggcgggcgg cccgcggggc cgggaggttc aggatcagga ggaggggatc 181 cagtcccggc ggatgtgcgg ggtctcgatg cccagggact tcatgtgctc gatcgggttg 241 gtgtactcgc ggctggcggc gatgcggccg tcgtgcagcg tgaatccgtg gatgaagtga 301 ttgcggtagc ggccctcgcg atagccgggg aagcggatcg tgccctcgcc gccgcactcg 361 accatgatgg tcgacgggtc ctgggtctcg tagatccgga cgtcggacca ctgccagtcg 421 ggcagcacgc gcagggacag ctcgccgtgc cgcttcagct tctcgcggcc cgtgacgacg 481 atggggcggc cgatgtcggt gtagaacagc gacgcggtgc cgtcctgggt gtagagggtg 541 taccggctca gccgggcctc ggcaccggtg cgcatgtact gctccacagc ccgccggttg 601 cgggcccgca ggtcgtggtg gtcggtgaac accggtgcgc cggcggcgct ttggggggcg 661 gatgacgaag tgatggtgtc tcccggaaag ttcgcagggt ctggcgggct cagggctgga 721 gccggctgat ctcccagccg ccgtcggtac gctcgtagtg caggcgctcg tgcagccggt 781 cggtgccgtt ggcccagaac tccacggagg cgggctcgag caggtagccg gcgaaggtcg 841 cggggcgcgg cagcggacgc agcggttcgc cgagccgcag ggcctcggag cgcagccggg 901 cgaagtggtc gaggttgtcc accggcacgc tctggcggga gaccgtcgtc atcgcgtgcg 961 tgaagacggc ccgcgcgcgc cacaggtcct cggcctcggc gtcggagagc cgggtgaccg 1021 ggccggcgag cgtgatctgc tgggtggtct cgcgccagta caggacgccg gaggcccagg 1081 ggttctcggc cagttcgcgg cccttgcggc tgccggcgtg ggtgatgaac acgatgccgg 1141 cgccggtcac tttggtgagg gcgacgatgc gggaggaggc gcggccccgc gcgtcggcgg 1201 tggcgagcgc cagtgcgcgg ggttcgcgca ccccgtgccc gacggcggcg tcgagccacg 1261 cggacagcag gcccatcggc tcggcgggcg gcgcgatgaa ctcggggaag ggcacgtgca 1321 gggcgccggt gagggtttcg gaacgggtgg agccgcggcg ggcggccacc gcggtgccgt 1381 tggcggagcg ggacgaggac aggtcagaca tggagcaccc cttcgatggt gacgacaccc 1441 gggcccgcga cctcgacgga ggtgacgtgg tcgccctcgc cgtgcgcgag ggcgcgcatg 1501 ggagaggggc ggccgatctc gacgccctgg atgatctcta tgcgctgccc gtacgggatg 1561 aggccgtgcc gggcgagatg gatggcgatg ggtcctgcgg cggagccggt ggccgcgtcc 1621 tcgacgactc cgtacgcggg cgagaacatg cggttgcgcc aggaacttcc ttgtccggca 1681 tagcagttgg tcgccatgtc ggggaagcgg gccagggcgc ggtggtcggg atccaccttc 1741 gacagcgcct cgatgctctc gaggccgacg aggacgtgcc gcgggccgtt gcggtagatc 1801 tccacgggga gcgtcgagcg gtgcaggccg agggcttcga ggagttcgtc ggtgcggtcg 1861 aagggctccc acacgggcac cggctgcatc atgctcgtcg cgacgacctg gccgtgtgcg 1921 cgctccagtt cgaaggggac gacgcccatg gcggtctcga tccgcagccg gtcggcgtcg 1981 gtccggcggc cgagggcgat ggcggtgccc agcaaggggt gtccggcgaa gggcagttcg 2041 ttgaccggtg tgaagatccg cacgtgggcg tcggtgccgt cctggcgggg gcggtgcacg 2101 aacgtggtct cggacaggtt catctcccgt gcgatgcgct gcatctgttc ggcgctcagg 2161 tcgtcggcgc cgaagaacac cgccaccggg ttgccggtga ggggctcgcg ggcgaacgcg 2221 tcgacgacga cgtacgtgtg catctggtct cccgggctgt gatgtcgggt gggtgccggg 2281 ccggcgctcg gggggtggac gccggcccgg cagtccgggg tgaggccgtg tgcggcgggc 2341 ctcaggcccg gtgggcggcc tgagccggtg tgagcagcgc ggccaggcgt gtgcccacga 2401 tgcgcggccc ttctcgggtc agcacggatt ccgggtggaa ctgcagggag gcgaagccgg 2461 gtccgctcag ggcgtggacc tcgccggtgg ccgcatcgcg gctgacccgg accgggccga 2521 cgccgtcggc gacgaactcg tcgtgctcgg tgaggagggc gaacgtgttg tagaagccga 2581 cgcgttcggc gctgccgaac aggtcgatcc gcttctggac gccctggttg ggcaccggcc 2641 tgcggcgcag cggcaggccg aggcgcagtc cgaggacctg gtggctgagg catacggcga 2701 agaacgggcg tccttcgcgc agcagggtgt cgacggcggt gtgcaggtgc cgcatcttgg 2761 ggtgggcaag ctcctgcggg tcgccggggc cgggtcccat cacgaccagg tcgtgaccgt 2821 cgaaggagta cggctcgtcg aagcggcgga ccgtcacgtg caggcccagg gactgaagtt 2881 gctggcccag catggaggtg aaggtgtcct cggcgtccac gacgaggacg ctgcgcccgg 2941 cgagttcggg ccgtgcggcc gtgcgggcct cggcgtcggt gagccagaag tcggcgatgg 3001 aggcgttgcg cagcccgagg gcctgccgga cgacggggtg gtcggcgaag cgttcggtgt 3061 cctgtgtgcc gccgagggcg gagacgaggg cggcggcctt ggcgtgggtc tccgcggctt 3121 cggaggccgg gtcggagtgg cgcacgatgg tggctcccac gccgatgccg atgcgtccgt 3181 gcgtgctgat gtcggcggtg cggatgagga ttgcggagtc catgacgcgt tcgccgtggg 3241 cgtcctgtcc gatgagtgct gccacgccgc tgtagtagcc gcggccgccg ggctcgtact 3301 gggcgatgat gcggcaggcg ctctgcaggg ggctgccggt gacggtgggc gcgaacatgg 3361 tctggtgcag gatgtcgcgc acgtcgcggt cggtgcgtcc ctcgatgaag tactcggtgt 3421 gggcgacctt ggccatttcc ttcaggtacg ggcccacgac ccggccgtcg ccggggcaga 3481 tccgcgccat catcttgagt tcctcgtcga gcaccatgta cagctcgtcg gtctccttgc 3541 ggtcgccgag gaattcgagg acgccggaga gggtgggtcc ggaggtgggg tagcggtagg 3601 tgccgctgat ggggttcatg acggccgtgc cgccctggag gctgacgtgc cgttcgggcg 3661 aggcgccgac gagggtgcgg gtgccggtgt ggatgaggaa tgtccagtgg gcgccggatt 3721 cgcgggtcag gagccggcgg aagagtgcgg gggcgctgcg tggcccgtag tcggtgatgt 3781 cggcgacgaa ggtgcgtttg atgacgaagt tcgcgccctc gccggtgccg atcatctcct 3841 tgacgatgcg gcgcacgacg tcttcgtagg ccgcgtcgtc gacgtcgaag tcgccgccgg 3901 cgagcggggt gggcacgtcg gggatgcggg cgagcgcctc ctcgatgggc agccgctgct 3961 ggccggtgac ggtcatcgcg acgagcgggg tgccgtcgtc ggcgcaggcg aagccccgtt 4021 cggccagctg ccggtagggc aggacgacga ggacctggtg gtgggctccg atgccgtccg 4081 ccgggctctc gggcagctcg atgtcggcga gggtggcggg cagggacacc tcgcccgtca 4141 ggacttccac gatgccgggg ccggtggcgc cgggccggtg cagcagcgcg tagggccgtg 4201 tggccgggcc ggccagggcc tgcgcgagca ggtcgcccgg gttcgtgtgc gggccgtgcg 4261 tcatccggtc tctcctttgt ggataccccg gcgtccgggg cggggtggaa gcgaagcttc 4321 tgcggaacag ggcggggaaa gccggtttgc cgccaggacg gcccagcggt caccggccac 4381 tgaccgacac gctgtgctca catggagact gacggcgtgt gaggcgtgat gcagcaggtc 4441 aggcgggcgt tcaagtaccg cttttacccc acggacgagc aggcggctga gctgtcgcgc 4501 acgttcggct gtgtccgtct cgtgtacaac aaggcgctcg aggagcgcac gcgggcctgg 4561 tacggcgagc ggtgccggat ctcctacgtg caatcgtccg ccgcgctgac gcagtggaag 4621 aagaccgagg gactcgcctt cctctcggag gtgtcctcgg tcccgctcca gcaggcgctg 4681 aggcaccttc aggcggcgtt cgggaacttc ttcgccaagc gggccaagta cccccggtac 4741 aaaagccgga agaagtcccg tgcatcggcg gagtacaccc gcagcgcctt cacgtggcgc 4801 gacggacggc tcacgctggc caggatggcg ggggccctgg atgtccgctg gtcgcgtccc 4861 ctcccgcagg gcgcgcagcc cacgacggtc accgtgtccc gcgacgcggc cggacgctgg 4921 ttcgtctcga tgctcgtcga ggatcccatc gcctttgcac ccgccacgaa cgcggcggtc 4981 ggcatcgacg ccgggatcac gtcactggtg accctgtcca ccggggagaa gatcgccaac 5041 ccgcagcacg agcggcgtga ccgcgcccgc ctggcgaagg cccagcggga gctgtcgcgc 5101 aaggcgaagg gctcggcgaa ccgggagaag gcccggcgtc gtgtcgccag ggtccacgcg 5161 cggatcgccg accggcgccg ggacttcctg caccagttgt cgactcggct cgtccgtgag 5221 aaccaaacgg tcgtgatcga ggacctcacc gtccgcaacc tgctgaagaa cggcaggctc 5281 gcgcgcgcca tctcggacgc ggcctggacg gacctgcgca tgatgctgga gtacaagtgc 5341 gcctggtacg ggcgtgaact cgtcgtgatc gaccgctggt tcccctccag caagctgtgc 5401 gggaactgcg gcacggtccg cgggaggctg ccgctgaacg ttcgagagtg gacgtgtgac 5461 agttgcggca ccgtgcatga ccgcgacgtg aacgcgtcac gcaacatcct ggccgccggg 5521 ctggcggcgt ctgcctgtgg agacggtgta agacctcaac gggagtcctc ccggacgggg 5581 cggtcgtcgg tgaagcagga accccagcgg gcgaccgctg gactcccccg cctgaaggcg 5641 ggggaggaag tcaaacgaac acctccttcg cggtgatgac gcgagcgcag cgctcggcgg 5701 cgtaggtgag ggcggagcgg tggtattcct gcgagaagtc ggcggtggcg tccgcgacga 5761 agaacggctg gatgtcgtgg gtgaaggcct cgacggcggt cgccaggacg ccgacgtgcg 5821 cgtacacgcc gcacagcacg agctggtcgc ggccggcggc gcgcatccgc tgcagcaggt 5881 cggtcttgaa gaaggcgctg tagcgccact tggtgagcag ccagtcgtgt ccggccggcg 5941 cgagggcgtc gacgacctgg cggtcctcgg gcgaggtccg catgccgggg ccccagaagt 6001 ccttgagcag gccgcgctgt tcgtcggtca tgccgccggg ctgggcggtg taggcgacgg 6061 ggacgccgag ttcggcgcag cggtcgcgca ggtgggcggc gttgcgtatc aggtcgtcgc 6121 gcaggctgtc ggggaacggt ttgaggaagt accgctgcat gtcgtggacg aggaggaccg 6181 agcggtcggc gtcggccttc caggacacga gggccgccgg caggtcgccc tcggcgggaa 6241 gcgggtatgc ggtgatgggg ggtatgccgg tcatggcttc ggctcctgtt cctgctcggt 6301 gcgtggggct caggcggtcc aggacgagat cacggagacg gcctgccacg gggtgaggcg 6361 ggggtcacag aaggacgtgt agcgctcgcc gacggtggcg aggtcggcct cggtgccagc 6421 gcactccgtg acgtcgtcgg gcgtggtctc caggtgcagg ccgccgggga caccgccggc 6481 gtcgcgcacg gcggtcacga agcgggagac ttcgagcgcg acggtctcca cgagccgtgt 6541 cttgtggccg ctcggcgcgg tgacggtgtt gccgtgcacc gggtcggtga gccagatcac 6601 cgggtggccg gcctcgcgga cggcctcgac caggcggggc aggcggtcgg ccacgttggc 6661 ggcgcccatc cgcgcgatca gggtgagctt gcccgggtcg cgccaggggt cgagccgctc 6721 gcacagcgcg agcagttcct cgggctccat cgagggcccg accttgcacg cgacggggtt 6781 gctcacctgg gagagcatgg cgatgtgggc gccgtcgacc tggcgggtgc gttcgccgat 6841 ccacggccag tgcgtggagc cgaggaagag ccggccctgc tcgtcgaggc ggagcagggg 6901 catctcgtag tcgaggagca gcgcctcgtg gctggtccac accgggggtc cgacgacgtc 6961 gcggccggcg ccgcgttcgc gccagccgag gtggtcgatg acgtcgctgg cggccatgta 7021 gccggtgagg atgcgcagcg ggtcggcgcg gcggctctcg gggtcgggtt cgggggcgtt 7081 gaccatgtgc cccttgaacg aggggagttc gacgccgtcg acgtcctcgg tgggcttgga 7141 ccggggcttg gcgaactgtc ccgcgatgcg tcccgcgcgc aggaccggtt tgccggtgat 7201 caggccgagc gccccggcga gcaggtcgag taccgcggcc ttgcgggcga cgtggtgcgg 7261 tccgcactcc tgcgggtcct cggcgcagtc cccggactgc accacgagtg cctggccgag 7321 ggccacggag ccgagctggg tccgcatggt ggccacgtcg tcgggctgta cgagggtggg 7381 gcgcgaggcc agcgcctcgg tcaccctgct cagttggaga aggtcgctcc attcgggctg 7441 ctgcagcgcc ccgcggacac gaatatcccg gatggcgtcc ttcacgactt cgttcatgcc 7501 gtactccgat ccagcggtga tgtcgttggc gtcaggaacg tcgtcaggtc gggattcccg 7561 tgcgtttgat ctcggggacc ggaattccca gggcccgcag ctgctggaac ggattcatga 7621 actcgcgctg ccgcttgatc ttcccgttct cgaactcgaa ggagtgcagg aagtggttct 7681 cgtaatagcc ctcggggtag tccccgaaac ggatcgttcc gtggccgtcg cactcgaccc 7741 agaagtggtc ggggtcgtcg gttgcgaaga tccggacgtt gtaccactcc cagtcgggga 7801 agcacgccag ggaccagacg gcgtgttcgc cgaggcggtc gcggccgtgg gtggcgacgg 7861 gcgagccggt gtcggtggtc cacaggccgc cgacgccgtc ctcggtgaac agctcgtgcc 7921 ggcgcagccg gtcctgcccg gtggtgttca tgtactgctc gacgacggcg cggttgtggc 7981 gccgggtctc cgactcgtcg gtgaattcct tggtgtctac tgattccggc acggtgaacc 8041 tctgtgtgtt ctcgggaggt gtgtccgcgg gaggtgtgtt cccgggaggt gtgttctcgg 8101 aaggtgttct cgggtgaacg gggtgaacgg caggggccgg gccgtggagg gaaggaattc 8161 ctccggtccg tctcagcgga tctgcggacg gtcacgggtc ccggccgcgc ggccgtcacg 8221 ggctttcgcg gcacagcgcg cgggcacgtg cacgggcgca ggcgcggggg cgcgggcgcg 8281 ggggtgcccg tcgggatgcg aaggggggga acgccgtcaa ttcactgccg cacatggctc 8341 atgcatgttt tcgggcagga aaggcgtgct caaatagtga cacggacgaa acccgcgcgc 8401 caagcgtccc tcgacgtgac ctcggtcacg ccaagggcct tgcgtgcaga gggagttggg 8461 cacgtgcgca gctgtcatga agtgcgctgt gtggcgctga tcgccatggc ggtcagttct 8521 tccttcgcgt cctcggtggc gctgctctcg cgcagcgcgg ccagggcccg gtcggtgcgc 8581 cgggtgatgt cgcgttcgat gtggtccacc gcgcccacgt cggtgatgac ggcgcgcatc 8641 gcggcgagtt cgtcgtcact gaccggggtc ccgatcttgg cccggaggaa tttcgccgcg 8701 tccgggtcgc gttcgtcggc gtagccgagg gcggccgcga acagcatggt gcgcttgccc 8761 tggacgaggt cgccgccgga cggtttgccg gtctcctcgg gggtgccgaa cacgcccagc 8821 aggtcgtcgc gcagctggaa cgcgacgccg atgtcgcgtc cgaaggcgcg gtaggcgtcg 8881 acgagtgcgg cgtccgcgcc ggcgatcgcg gcaccgaggt gcagcgggcg ctccaccgtg 8941 taggaggccg tcttgtactg gttgacgcgc agcggtgtgg cgatgtcctc gtcgcccgcc 9001 gcctcggccg tcacgtcgag cagctggccg aagaggacct cgttgcgcag cgccgaccac 9061 accggggaga cccgcgccag cgccggtgcc ggcagcccgc aggtgtggat caggtcgtcg 9121 gcccagccct gggcgaggtc tccggtcagg atcgcggcgc cggtgccgaa cagttccgcg 9181 ttgccgttcc agcactgccg gcggtgccgg tcggcgaaca tcacgtgcgc ggccggggcg 9241 ccccggcggg tgggtgacgc gtcgacgacg tcgtcgtgga tgagggcgga ggcatggaac 9301 agttccagcg cggcgcagac gcgcaccacc gccggggccg tggcgtcctg tgcctcgcct 9361 ccggcgccga gccagccgag ccaggcgaag gtcgggcgga cccgcttgcc gccgcgcagt 9421 acgtaggtct ccagctcggc gaccgcgtcg gcgcaggccg ggccgatcgc cgcggcctcg 9481 tcccggcggg cggcgaagaa ctggcggagc gcgtcctcga cgacctccac ggggctggtt 9541 cgggtgctcg tcgtcatcgc gtcaacttcc ctggtctctt cggagtcgga cagcagcgtg 9601 cggcgggtcg gccggggctg ccgctgggga gtacgcctgg agcccggagc gctccttcgg 9661 cccgccgtca cacacgcagg gccgaaggaa cccccgccgg ggggtctggc gcggcgttcg 9721 ccggtgcccg cgccggacgc gatcacgtgc aggggcggtc ctgccggctc cccggtggcc 9781 gaggaggggc gggccaagtc cgtggtctcg gacaccgctc ctgcgtggtc cgtgctcgtc 9841 gctcgccgtg ttccgttgcg cgccgtgctc cttcgcgtac gggtccgagt atcgaagggg 9901 tgactcgatg tccggtcgag tcccgttgat gcgcgtacgg gggccggcgt ccgcgatgga 9961 gcctttctgc atctgaggtc gaacttccgc tacgggtaag gaattcggtg gccgatcgct 10021 cctaggatgc gccgggagcc ccccacccgg ggcgtgcccg ccccctcgcc gtcctgcggg 10081 gcggcggcgg gcacgcccct cccctcctgc ggacggtgcg acggcccgcc gcagccgtcg 10141 ccgaggagcc ggtgtgatca aagccgagga gttcgcgagg ctgcggcccc tgctgttcgc 10201 gatcgcctac cggatcgtgg gtgacgaacg gacggcccgc tacgccgtcc aggcggcctg 10261 gctgcgctgg atggccgcgc ccgcgcggcc cgagccggcc gaggggtatc tggcggccga 10321 ggtcacccgg gtcgcggccg gggctctgcg ctcggcccgc gccgagcggg gagaactcgt 10381 cgctccgctc ctcggcgagg gcccccggga ggcgggccgg ccggcgcagc tggcggactc 10441 gctgtcgctg tcggccctgc tggtgctgga gcggctgtcc ccgctcgagc gtgccgtctt 10501 cgtgctgcac gaggcgttcg ggtgcgacga ggcgcagatc gcgtcggccc tcggctgctc 10561 ccgggaggcc tgcggccagc tcctcgccgc cgtcgcggcg gtcagcgacg gcgggcgcga 10621 gccgctgccc tggccgacgt gtgtggaggg cgcgggcaac gccgcccgga tgatcgccgc 10681 gatcgtcccg cccctggtgc gcgtcggcgt cacgctcgag gagagccggg tcggtgacag 10741 gccgggctgg gtcttccgcg accgggacgg cgcggtcctg cacaccatgg tggccgatgt 10801 cgtggacggg cgggtccagc gcgtccatct ggtcgtccac cccggcggcc accggcacgc 10861 cggcccggtg gccgaggcct gcgccctgct ccgcgaggcg aaccgggccc gctgagcggc 10921 ctgccgcggg cggcgcgtgg cgggtgggcg gctctcgagg tgcccggccc tcccccgtct 10981 tgcggctcag ccggccgtgt cgcgttccgg cggcaggatc agggtcggct cgaggacgac 11041 acggggcacg ggcacggggt cggggtccgg gcgggccagt tcggcgcgca cgccccgctg 11101 ctgacgccat ccggcctggg cggcgacgac ggcgacgtag gggatgacga ccccgccggc 11161 cagcgcgcac accgcgacgg ccggccagcg gctccaggtg agcgccatca ccaccacgca 11221 ggcgctgcgc accagcatgg ccgtgacgta gcggcgctga cggccgcgca gatcctgggt 11281 caggccgatg cgggccccgg tgatggaatc ggcccgggtt ccctctcggt gccatggact 11341 gcggctcatc ggacctccgt gggtcggggc aactgggcgg gcgggtgtcg ccctgccctg 11401 ggcgcgctcc ccggtgcgcc gcgcacacgg cccggcgggc gtggaacgac agcggcgcgg 11461 gtgaccgtcc cctgatcacc cgcgccgtct gtccgccggc cggtcctgcg tgtcgtgccc 11521 gggtcagtgc acctgctggt cgtgctccct ctcaccgacg gcggcgtgtt cgccgtcggc 11581 ggggtgcccg ttgagcgagg gggcgtgccc gttggacgag ggggcgtggc cgttggacga 11641 gggtgcgtgg ccgaggtgct ccagggcttg ctgcatctcc tgcaatgtcg gcgtcgggac 11701 ctcgtcgccg tacagccagc ggctgagccg gtggcgccgc cgcttgcggc ggacgtccgg 11761 gtcgggtacg ccgtccccgt ccgccggctc cggggccggc aggacctcgg gtatctccct 11821 cgacagcagc ttgtactcca gcccgcggtc gatgcgctcg tggacctcga cgaactcgcc 11881 gtgcggcagc cgcttgatcc gtccggtctc gcggccgtgc aggagcttgt cgcggtcgcg 11941 ccgctgcagg ccgaggcaga tccgcttggt gatgacgtac accagcagcg ggacgacgac 12001 gagtccgacg cgcacggccc aggtgatcga gttcagggac aggtggaagc gctcggccag 12061 gacgtcgttg gcgccgccga agaacagcac caggtagaag gagacgaagg cgaggccgaa 12121 cgcggtgcgg gtgggctttt cgcggggcct gtccagcagg tggtgttcgc gtttgtcgcc 12181 ggtgccccag gcttccagga agggccacat ggcgaacacc accatcatga cgccgggcag 12241 gatgacggcc ggcagcagga cgctcatgtt gacggtgtag ccgccgggca ggacgaactc 12301 ccaggcgggc atggcgcgca gggctccttc gaggaagccc atgtaccagt cgggctggga 12361 gccctgggag atctggtcgg agcggtaggg gccgtaggtc cacacggggt tgatctgggc 12421 gatgccggcc agcagcgcga gcaggccgga gacgaggaag aagaacccgc cggccttggc 12481 cgtgtagtgc ggcatcaggg gctggccgac gacgttgttg ttggtgcggc cggggccccg 12541 gaactgggtg tgcttgtggt agaagaccag cagcaggtgg agggcgacca gggccaggac 12601 gatgcccggg atcagcagga tgtggatgct gtagaacctg gggatgacgt cgtgtcccgg 12661 gtattcgccg ccgaacagga acagcgtcag ataggtgccg accaccggga tggcgagcgt 12721 gacgccttcg gcgatgcgca ggccggtgcc ggagagcagg tcgtcgggga gcgagtatcc 12781 gacgaagccc tccagggtga ccagcaccag gatcacgaag ccgatcagcc agttgacctc 12841 gcgcggcttg cggaacgatc cggtcaggaa gtgccgcagc gtgtgcatca tgagcgcgcc 12901 gatcatgatc agcgccgacc agtggtgcag ctgacggatg aacaggccgc cgcgcacgtc 12961 gaaactgatc tcgatggtgg tggcgtaggc ctgggacatc gggatgccct gcagcgggac 13021 gtacgacccg tcgtagaccg tctcggtcat gctcgggtcg aagaacatgg tgagccagac 13081 accggtgagg atcagcacga tgaagctgta gagcgcaatc tcaccgatca tgaacgacca 13141 gtggtcggga aagaccttgc ggatcaggaa ccgcaagctg tagatcccga gccgcccgtc 13201 cgcccagtcg gcgacgcgtt cgcccttgga cggtattgtg cgcgccccct gtggcgcctc 13261 ctcggtcgtg ctcatacctg cgcgccctcc cctcgccgct cggccgtcac aggcacacct 13321 acgccggccg tcgagcggtc ggtggtgagg acggcctgcc gcggcgcaag cgggcccgtg 13381 ccctggagcg gatgaaacgc tatcgacgcg tggtgaaccc gaacaaccgc gctcaagtga 13441 tcctcgagtg gcggctccag tgactctgga gagagttggg gggcacgcgg ctgtgcgcgg 13501 acggctgtgg cgccgaccgg ttgctccacc tctgtcatga cgcagagcgt aggggggtgc 13561 gaagggggcc gcgacggcgt tgatttcgcc atgtggcgtg taaacgctgg gcagttcacg 13621 gtcgccggcg atcgccggcc ggtgccgcgg cgggccagtg ggccgaggag ccggcgggcc 13681 ggggcgcggt ggagccggcg gagacgccga tgacgggtgc cgtgggcccg gcgggccggc 13741 gccggcgggc gtcgggggcg tgggtggcgg tgggcggcgt cgcgggggct gcggccgggg 13801 ggcgcagcgc ggcccgcagg gcgcgcggcc gcagggcggc gggcgggtcg agggattccc 13861 gcgcggcgag cagcatcgtc gccgcgtgcc ggtcggcggt cgcggcggcc gcgagccggg 13921 acgcgtaccg cgcgccgagc cggccgcgca gcccgcccgg cgggcccagg ggtccggtgc 13981 tcgaccgcca ggcgggggcg atgcggtggg ccagggcccg gcgcaggcgg tagccgatgc 14041 cgacggcggt gccgtgggcg gtgagcagat ggtccaggac gagcgcgcac tccacggcaa 14101 aggtcatgcc gtggccgtgg gcggggtcga gtggggcgag ggcgtcaccg acgacgagga 14161 actggtcggg aaagctgcgc agcttctcgt agtggcgcca gcggctctcg gtgcggcagg 14221 tgtagacggg gccgagcggg gtggcggcct cgatgaggtc gcgcagcagc ggttcgcgca 14281 aggtgccggc ggcgtgcagc agttcggcgt ggtcggcggg cggccgggtg ccgtcgccgg 14341 cgccgatcgt caccgaccag cggccgccct cgacggggtg aagcacggcc tggcgcgggt 14401 cgccgggcgc ggccatgtgc atcaggctct tgaagtcggc gacatgaccg accggcggcg 14461 cgtacagcgt ggtggcgtac gtcgtcgcgg cggcggccgc ggattcgtcg ggcggcgcgt 14521 agcccgcctc ggcgagccac tgcggggcgc gggagccgcg tccggaggcg tccaccacga 14581 actcggcggc tatcgggcgc cggggggcga agccgtcggg ggccttgcgg tcccggccgc 14641 gggcccagac gccggtgacg gtgtcctggg ggccgggctg cagggcgacg acctcgtgct 14701 cgggcaggaa ggtgaccttg gggtcggcgc gcagccggtc gcgtacggtc gcgtcgatca 14761 ggtcgcggcc ggcgctgagc aggggcaggc ccgcgtcgaa gcggggcagc cagccggccg 14821 ggccgagcag cagcgtgtcc tcggggacgc ggacgtggac cgctccggcg cgcaggaggt 14881 cctggcggat gccggggaac agccgctgca ggccgtcggt ggcggcggtc gtgaggctgt 14941 gggtgtgccg tgcctggggc acaccgcggc ggcggccggg gccgcggggc agccggtcgc 15001 gttcgatgac ggtgacccgg tccatgaatc ccgccagggc gcgggccgcg gtgagcccgg 15061 cgaggccgga gccgatcacc acggcatggc cgtgcccgcc gtttgtgccg acaacacgtg 15121 cgtccagagc caactcggcc gcctcccctg tgcgttgtgc ttgcatcatg cgccgcgggg 15181 ccgtcggcgc ggccgggttc agcggtgtct cgagcggtat tcgagagggg cacgaggggg 15241 attcgaggac gggtgcgggg cgggtgcggg acgggtgcgg gtgcgagggc ccggcgggcg 15301 ggccggggcg gcggtgcgca ccggggctcg gccgtgtcgt gccggggtgt tccgggcccg 15361 gtgggggcat cgcgcgggtc tgcgcggcgc cgtggtgcct gccggtgagg ccctggcggc 15421 gcgggccgga cccgggccgg gcgtcccgcg ccgggggcgg cgtacgccga cggtgtgtcg 15481 gcgtacaccg tcctgtgcgt gtgccgtgca caggtgcaca ggtgcacagg tgcacaggtg 15541 cacaggtgca caggtgcaca ggtgctcagg tgctcaggtg ctcgggtgct cagggcgacg 15601 gggtccgtgt gcgctcgggt gccgtcgtca gggcccggtc cacgagcggg ccggcgacgc 15661 cggtgtatcc ggccgggtcg agcagggccg tcacctcctc ccggctcagc acgcccgcca 15721 gttgcgggag ttcggccagg atgtcgccga gcggcaggcc cgtgcgggag gcgagcaccg 15781 aggcctgggt gagcagttcc ttcgcggccg tcctgcccat gcgcggtgcg aggacggccg 15841 agacgcgctc ggagacgagc cggccgccgg tcgcctggag gttgacccgc atccgctccg 15901 ggtggacggc gagtccccgg gcgagttcga cggccgtgtg cgcggcgccg ccggtcagcc 15961 gcagggcctc gcgcagcggc tgccattcgg cgtgccacat gccggccgac cgctcgtcct 16021 cggtgggcag gcactgcaga agtacggtgg ccagcgcggg cacctggagg gcggcggagc 16081 ggatcagggt ggccaggacg gggttgcgct tgtgcggcat cgccgaggag gcgccccgtc 16141 cggcgaccgc cggctcggcc acctcgccga tctcggtgcg ggtgagcacc agcacgtccg 16201 cggcgatctt gccgagggcg ccggtggtgt gggcgagcgc ggtgcccagg tcggcgacgg 16261 gggtgcgcag ggcgtgccag ggcaggacgg gtacggccag gcccgtctcg tcggcgaacg 16321 cggcggagag cgagtcgagt acgcgggcgg ggtcggcgcc ctcgccggcg tactgcagat 16381 agccggcgag cgtgccggcc gcgccgccga gcgcgaccgg gagcccgccg cgggtgagcc 16441 gttccaggcg ttcgacggcg tccaggacca gcgcgtgcca cccggccgcc ttcagcccga 16501 aggtggtggg cacggcgtgc agggcgaggg tgcggcccgc catcacggtg tcgcggtgcg 16561 cggcggcgag tgcggccagc gcgtcggcca ccgcccgcag gtcggcgacg atcagccgca 16621 gcgcccgctg ggcgaccagc atcgcgccgg tgtcgaagac gtcctggctg gtcgagccgc 16681 ggtgcacgta ctcggcggcc tgcggggagc gttcggcgac gaccgcggtg aacgccttga 16741 ccaggcccac gaccgggttc gcggtctccc gtgcggccag cgccagttcg cgtacgtcga 16801 gcaggtcggc gcgggcggcg gcggtgatgg ccgcggccgc ctgggcgggg accgtgccgc 16861 agcgggcctg ggcgcgggcc agccccgcct ccgcgtcgag catcgcctgc agccaggcgc 16921 ggtcgccgac ggcggcctcg gcgggggtgc ccgccctgac cggcgagagc agcccggcgt 16981 ccaggtgggt gccaaggaca tgcgtgcgct ggtcctcgta cagggaagtc atgcgctcgc 17041 cctcgctttg ctggtcttgg gctgcggtgc ggcagtgggc agttcgggca gggcgaggac 17101 ggccgccgcg atcgcgtcgg agtcttcgag ggtgaccgag ccgacgcccg gtctgatgcc 17161 ggcggcggtg acccagtgca cggactcggt gggcacgccg taggcgaagc gccgcggatg 17221 cggcgtccct tgggcgtcga ggagccggta gggccgctcg gagacggcga gaccaccggt 17281 ctcgtagtcg gcgccgtcgt gcccgtcggg tccgggaatg cggaaggggc ggcactgccc 17341 ggtgcgcagc agccggctca tcagcgggtc cgcggtgcgc cgcaggtcga tctcgggcag 17401 gcgggcctcg atgaggacgg tggcccgcac ccgcaccccg ggtatctcgc tcgacgtcgc 17461 ggtgaagcag gggccgagcg ggtcgtcgtc gtcggtggtg acgcgcaggc cggggccggt 17521 cacgtcgagg atgccggcgt ccaggagcgc ggccatttcc tctatgcggg aggcgggcgg 17581 gccgatggac agataggcgt tgagcggggt gtaccagccg tcgaggtggt cgcggtggga 17641 ctcggcgctc aggccggcgt ggtcgacggc gagccgcagt tcgttgcgca ggtcccgcag 17701 gacgtcgagg gcggctttga acggtccgct gacgttgccc tggcgggcca ggcggacgtc 17761 ctggtcgagg tggccgcgca gccaggcgcg gaaggcgttc cggtcggtga gggcgcggct 17821 gtcgtagggg cgcgcgacgc gctcccagtc ccagcgttcg gcggcggtga caccgctgtc 17881 gtccagcagc cgggcctcct cctcccccgg ttcggcgtgc aggtactttt cggtgaagtc 17941 ctcgatgacg gacgggggtt caccgcgcgc cgcgagcagc gccgcgtagt ggacggcgca 18001 cacctccttg gtgatgaggg gccacaggtc ggcggcgaag tcgatggccg ggcggtgcgg 18061 gctgcggcgg cgcagcccgg cgatgtagtc ggtggtcagc agcctggggt ggtggcggcc 18121 gtgggcgccc ttctcgttct cgccgcgtgc ctggtagggc acgccgcgcc gggagccggc 18181 gtacaggcgc ggttcgcggc cggagggccg gtagacgagc cggccgtcga cgcgggtgaa 18241 gtcgccgccg cggccgtggg tgaacagggc caggtagtcg aagaagttga ggccgagccc 18301 gcgcagcagc acgggttcgc cgggcccgat gccggacagg tccacgtcgg ccgggttggc 18361 cggggccagg taggtcagcc cgtggcgttc ggcgtacgcg ctcatctcgc tctgcgtgcc 18421 gcagggttcg accggcacgt ggccctgggc gaggacgacc gcggacagtc cggtcaggcg 18481 ggtgccgtcc tccaggacga cggtctgcgg ccccgtctgg ccggcctcgt cgtcgagggc 18541 gacggcgcgc acggcgtgcg tgcgcaccct gacgtgggcg gcggcgccgg cgacgacccg 18601 ccggaacgcc cacgtcagat agcagccgta cagggcgcgc gtggggtagc tgtcggggcc 18661 gagccggtcg gcctcggcga ggacgtcgtg gtggtaccgg cactccgcgt ccggttccag 18721 ggtgcccgag gtcagggcct tcgcccactg gtacaggctg ggcccctcgt ccagcgggcc 18781 gtcgatgcgg acgctggcgt cggtgtagac cgtgacctgc gaggacacgg tgttcatcag 18841 caggtgccgg gactgcgtcg ggcgccacac gcgtcccgcg cccggcgggt cggggtcgac 18901 cacgtggacg gtgacggcgt cccagcgcgg cgacttccgt tcctgcgcac agagccgttc 18961 cagtacggaa aggccgcgcg gtcccgcgcc gacgagacag atctgcacat gtgtcatggc 19021 tgcgctccct gtggacacgg cgggctcccc tggtgccggg cggccggccg ggaccgggtc 19081 acccgggacc ctcggagcgg ccgccgtcgt gcgcggccct gcggtgcctt cgacgcttac 19141 tgcgcgttcg cctccatgcg taccgtccac agtgcctcct ttctccgcca cggtcggggc 19201 aggcgctcaa caaaggctca gattcgggtg gaacctcgct cgagaagcgg gaagacggcg 19261 cggaatccgg cattcggcgc tccctggcgg gccgcgaacg gggctgtatc gggactccag 19321 cgcgggtcgg tagcttcgtc gaaaagcgtc accgatccca cttcgggcca aaaatggcat 19381 cggctcgccg gggacgcggg aggggaatct tggatcccct cggagaatcg atcggccgcg 19441 agcgcgcgac gcgcacgcag gagttcggaa atggcggggg ccatgggaca cggaataatt 19501 cagccgaaat cgcgatcctt tttgtggcgc cgatccgggg tcacgcgtcc tgcattcact 19561 gccgtgatca gcagggaaaa catatggaat tcatgaaggt tgcggagggc gggccgcctc 19621 atgaaggaga ttcgatgatg gttcacccgt gcaccaggag ccacgacgag gagagccgcg 19681 ccgccgccgg gtccctgctc tgcgccgcct gcgtcgcaca ggtggaacgc agtctgcggg 19741 cactccccgg gctgcaccag gaaagcctgc accacgtgtc gccgacgccc cggcggacca 19801 acccgaccag ggtgtcggga agtctgcggc gggaccgcct gaacatctcg gtgctggatg 19861 cccggcacaa catcctcgcg acgctcgagt cctggtcgga aatcgtcgtg gagcagttgc 19921 ggatccccgc tccggcgcgc tcggtgccgc agttggcgag gtttttgacc cggcatcttg 19981 cgtggctggc cgcccagccg ccggccgccg atttcgcgga cgagatcgag agcctggtag 20041 ccgagttgcg cagcacgata gaccccgacc ccggcggcct cagcgcactc atccggcagt 20101 gtgtggtgga cgactgcggc gggaagatca gcgcttccct gaaaagcacc gggaactcgg 20161 ggagccggag catcgagtgc tccgcggggc attcatggga aatgaccgaa tggctgaacc 20221 tgaggcggct catggagcag cagcgaaagg gtgtcaccgt atgatgaaac cgccgcgcca 20281 cagactcgtc cccacgaatg tggcggcgct cgccgtgggg gtgtccgagg cgaccatccg 20341 caagtgggtg agccggggga agatcacccg ctacggggcg ccgaactgcc gctcccagtt 20401 cgacatcgac gagctcaccg agatcgccct gcagcgcccg tcccggcctt cgccgcaccg 20461 tcacggcggc ggggcccgcg cggcgcagca ggcctcggcc gcccggtgac ccgtggcaca 20521 cgcgcacgac ctcgccgccc cctgcccggc gttcgcgcct tcgcgcgcca acgccggtca 20581 gggggccgcg tgttgggcga ccgggccccg gccgaagtgg cccaggtcac ttttcggtgc 20641 tcttggcgcg acgacgaccc ccgtgtcact atctacgcac atcccccctg cccaaaaacg 20701 gccaggggac ggcggtttgg gtaccgcggc cgccggtccg ctcaggacgg accgggcttc 20761 ggcgacgtac cccaccggct ttcaccgcat cgggccactt gcgtacacac ggcagttcgc 20821 gtcgatcccg cgcgccgtga cggcagcaat gcccggcacc tgcgtatcca cacatcccgc 20881 cgcaccttcg cggcagcctg cgccgccgtg tgcggacggg gacctgacgt cctgcctttt 20941 ttcttcctag agatccgcac gacgcgatct cgctgcagaa acgacaaggg gagctgagtg 21001 ggttgacgac tctaccgacc tcagtggaaa gggtttcgga agaccgccgg gctcgctcag 21061 tcggcatcgg ccgcgcccat gccaaggcca tcctgctggg agagcacgcg gtcgtgtacg 21121 ggacagcggc gctggctctg ccgattccgc agctcacggc cacggcgagc gccggcaggt 21181 cgtcgcccgc caccgacgcc cagggcgagt tgtccttcac catgaccggc tccgcgtcgc 21241 gggcggtggt gacgcgcgcc tcggacggcc tgcgccggct gaccgcggcc ttcaaggagc 21301 gcatgggcgt cgaggacacc acgcatctcg acgtgatcct cgacggcgcc atcccgcccg 21361 gccgcgggct cggctcgagc gccgcgcact cgcgggcgat cgtcctcgcc ctcgccgacc 21421 tgttcggtct cgaactggcc gacagcacgg cgttcgagct ggtgcaggcg gccgagaacg 21481 aaacgcacgg ccgggccagc ggcgtggaca ccaaggccgt ctgcgcggcc ggcccgctgc 21541 ggttccaggc gggcgaggta cgggagttga gcatcggccg cgacggcctg tgcatcgtcg 21601 ccgacagcgg caccgcgggc agcaccaggg aagcggtcga gctgctgcgt gcgggattcc 21661 ggcgcgaggc cggggcgcgg gacaggttcc tgcaccgtgc cgcggagctc gtcgccgagg 21721 ccgagcaggc gctcgccgag ggcgagcagg aggagttcgg caggcggctg acgggttatc 21781 acgagctgat gcgcggcgcc ggtctgagca ccgaccggat cgacgcgatg gtcggggccg 21841 cgctcaaagc gggcagtctc ggcgccaaga tcaccggtgg tgggctgggc ggctgcgtcc 21901 tggccatgac ccagcccgac caggccaggg aggtcacccg gcaactgcac gaggccggcg 21961 ccgtacagac gtggatcgtg ccgctgagga ggcgggtcag ccgtgcgctc tgaacagctt 22021 ctgcgaccgc gggtgcggga gggggcggcg gacgccaccg ccgtcgcgca cccgaacatc 22081 gcgctgatca agtactgggg caagagcgac gagcggctgt tcctgccccg caccgacagc 22141 ctgtcgatga ccctggacat cttccccacg accacccgcg tccggctcgc cggcgcggcg 22201 gagcacgaca cagtcacgtt caacggccgc cccgcgacgg gcgaggccga gcggcgcatc 22261 gtggcgttcc tggacctggt gcgcgagcgg gccggcgtcg aggggcgggc cgtcgtcgac 22321 accgagaaca ccgtccccac cggcgcgggt ctggcgtcct cggcgagcgg gttcgccgcg 22381 ctcgccgtcg ccgcggccgc cgcgtacggc ctggacctcg atgccgccgg cctgtcccgg 22441 ctggcccggc gcggatccgg atcggcctcg cggtcggtgt tcggcggctt cgccgtgtgg 22501 cacgccggca cgaccgcggg caccgccgcg caggcggacc tgagttcgta cgccgaaccg 22561 gtgcgggccg caggcctcga cccggcactg gtcatcgccg tcgtcaacgc gggccccaag 22621 gcgctctcca gccgggaggc catgcgccgc accgtcgaca cctccccgct gtacgagccg 22681 tgggcgctct ccagcaaggc cgacctggcc gacatgcggg cggcgctgag ccgcggcgac 22741 cttcccgcgg tgggcgagat cgccgagcgc aacgcgctcg gcatgcacgc cacgatgctg 22801 gcggcgcgcc ccgccgtgcg gtacatctcg ccggcctcgc tgaccgtcct ggacagcgtg 22861 ctgcagctgc ggcaggacgg cgtgccggcc tacgtgacga tggacgccgg cccgaacgtc 22921 aaggtgctgt gccggcgcgc ggacgcggag cgggtcgccg agaccgtgcg cggcgccgct 22981 cccggcggcg cggtgcacat cgccgggccg ggtccgggcg cccgcctgct cagcgaggac 23041 ggatgacgac cggcgcgcgc accgtggtcc gccgcgcgcc gggcaagttg ttcgtcgcgg 23101 gcgaatacgc ggtggtcgaa cccggcaacg aggcgatcct ggtggccgtc gaccggtaca 23161 tcaccgccac cgtgagcgcg gccgtcgagc ccggcacggt cgtcatctcc tccgacctcg 23221 caccgcgcgc gctgcaccgg cactggcgcg acggccggct ggccgggggc gacgggcagt 23281 tgccccctgt ggagtccgcg atcgagaccg tgagcgacct gctcgccgaa cgcggcctgc 23341 cggcccccgc gctgcacatc tcgctcagca gcaccctgca cgagcggggc aggaaatacg 23401 gcctgggttc cagcggtgcg gtgaccgtgg cgagcgtcgc ggccgtgtcg gcgtactgcg 23461 gtctgcggct cacgcccgac gagcggttcc gcctcgccct gctcgcctgc gcccgcatcg 23521 accccaaggg ctccgggggc gacctcgccg ccagcacctg gggcggctgg atcgcctacc 23581 gggcgcccga ccgggcccgg gtcctcgacc tggcccgcag cctcggcgtc caggaggcgc 23641 tgcgtgcccc ctggcccggt ttctcggtac ggcggctgcc gccgccggcc gggctggacc 23701 tgcaggtcgg ctggacccgc agcccggcct cgaccacggc tctcgtgtcc gacctgcacc 23761 ggcggccctg gcggggcagc gcctcgcacc accggttcgt ccaggccacc ggcggcctgg 23821 tgcgcgccgc cgtcacggcg ctcgaggccg gcgacggccc ggggctgctg cgggagatcc 23881 ggcgggcccg gcaggagctg gcccgcctgg acgacgaggt cggcctcggc atcttcacgc 23941 ccgcgctgac cgcgctgtgc gacgcggccg agggcgtcgg cggtgccgcc aagccctcgg 24001 gcgcgggagg cggcgactgc ggcatcgccc tgctcgacgc cggcgccccg cacgacatct 24061 cgcaggtacg gcaacggtgg gccacggccg gggtgctgcc cctgcccgtc cgctccgccc 24121 cagaagggat cgaggaatga gtagtgctca gcgcaaggac gaccacgtcc ggctcgccat 24181 ggagcagcag catgcgcaca gcggacgcaa ccagttcgac gacgtgtcgt tcgtccacca 24241 cgccctggcc ggcatcgacc ggccggatgt gtccctggcc acgaccttcg ccggcgtcgc 24301 ctggcaggca ccgctctaca tcaacgcgat gaccggcggc agcgccaaga cgggtgccat 24361 caaccgggac ctggccaccg ccgcccgcga gaccggcgtg gccatcgcgt ccggttccat 24421 gcacgcctac ttcaaggacc cctcctgcgc ggacaccttc cgggtgctgc gcacgcagaa 24481 cccggacggg ttcgtcatcg cgaacgtcaa cgcgacggcg tcggtcgaca acgcgcggcg 24541 cgccatcgac ctgatcgagg cgaacgccct gcagatccac ctcaacacgg cgcaggaaac 24601 ccccatgccg gagggcgacc ggtccttcgg gtcctgggcg ccgcagatcg agcggatcgc 24661 ggcggccgtc gacgtgcccg tgatcgtcaa ggaggtcggc aacgggctga gccgccagac 24721 ggtcctcgcg ctggcggacc tcggcgtgcg ggcggccgac gtcagcggcc gcggcggcac 24781 ggacttcgcc cggatcgaga acggccggcg ggaactcgcc gactacgcct tcctgcacaa 24841 ctggggccag tccacggtgg cctgtctcct ggacgcgcag gacgccggca tccccgtgct 24901 ggcctccggc ggggtccgcc acccgctcga cgtggcccgc gccctggccc tcggcgcccg 24961 cgccgtcggc tcctccggcg gattcctgcg caccctggtc gacggcggcg tcgcggcgct 25021 cgtcacgcag atctcggcct ggctcgacca gctcgccgcc ctgcagacca tgctcggcgc 25081 gcgcacgccc gccgaactct cccgctgcga tctgctgatc cacggcgagc tgcggaactt 25141 ctgccttgac cggggcatcg acacctggcg gctcgcccag cgttccagct ccctcgacgc 25201 cctccacgag atgacgggaa gcacacgatg actgaagcac acgcgatcgc cggagtcccg 25261 atgcggtggg tggggcccct gcgcatctcg gggaacgtcg ccgacaccga gatccaggtt 25321 ccgctggcca cctacgagtc gccgctgtgg ccgtcggtgg gccggggcgc gaaggtgtcc 25381 cggctggccg agaagggcat cgtcgccacc ctcgtcgacg agcggatgac gcgttcggtg 25441 ctcgtcgagg ccaccgacgc gcagaccgcg ctcacggccg cacgcaccat cgaggcccgc 25501 atcgacgaac tgcgcgaagt cgtgcgcggg tgcagcaggt tcgccgagct gatcggcatc 25561 cggcacgaga tcaacgccaa cctgctgttc atccggttcg agttctccac cggcgacgcc 25621 tccggccaca acatggcgac cctcgcctcc gacgcgctcc tggagcgcct gctgcgcacc 25681 gtcccgggca tctcctacgg gtcgatctcc ggcaactact gcacggacaa gaaggccacc 25741 gccatcaacg gcatcctcgg ccgcggcaag aacgtggtca ccgagctgct cgtgccgcgt 25801 gacgtggtgg cgggcgtcct gcacacgacg gccgcgaaga tcgtcgagct gaacatccgc 25861 aagaacctgc tcggcaccct cctggccggc ggcatccgct cggccaacgc ccactacgcg 25921 aacatgctgc tcgcgttcta cctggccacc ggccaggacg cggccaacat catcgagggc 25981 tcccagggcg tcgtcatggc cgaggaccgc gacggcgacc tctacttcgc ctgcaccctg 26041 cccaacctga tcgtcggcac ggtcggcaac ggcaagggcc tgggcttcgt ggagacgaac 26101 ctgacccgcc tgggctgccg ggccgacggc gcccccggcg agaacgcccg ccggctcgcc 26161 gtcctggcgg cggccaccgt gctgtgcggt gaactctcgc tgctcgcggc gcagacgaac 26221 ccgggcgaac tcatgcgcgc acacgtccag ctggaacgcg acaacaagac cgcaaaggtt 26281 ggtgtctaag gcatgtccct ctccatcgga atccacgatc tgtcttttgc cacggcggag 26341 ttcgtcctgc cgcacaccga actcgccgcc cacaacggca ccgagatcgg caagtaccac 26401 atcggcatcg gccaggagtc gatgagcatc cccggcgccg acgaggacat cgtgacgatg 26461 gccgccgcgg ccgccgcgcc ggtcatcgcc cggcacggcg gcgaccggat acggacggtc 26521 gtcttcgcca cggagtcctc gatcgaccag gcgaaggcgg ccggcatcta cgtccactcg 26581 ctgctcgggc tgccgtcggc cacccgcgtc gtcgagctga agcaggcctg ctacggggcg 26641 acggccgccc tgcagttcgc catcggcctg gtgcggcgcg accccgccca gcaggtcctg 26701 gtgatcgcca gcgacgtctc caagtacgaa ctggacagcc ccggggaggc cacccagggc 26761 gcggcggcgg tggccatgct ggtcggtgcg gaccccgccc tggtgcgcat cgaggacccg 26821 tcgggactgt tcaccgccga cgtcatggac ttctggcggc ccaactaccg caacgaggcc 26881 ctggtcgacg gccacgagtc catcaacgcc tatctgcagg cggtggaggg cacctggaag 26941 gactacaccg agcagggcgg ccgcgcgctg gaggagttcg ccgcgttctg ctaccaccag 27001 ccgttcacga agatggccta caaggcccac cgtcacctgc tgaactactg cggccaggac 27061 accgacaacg acgccgtcac cgccgccctc ggccacacca cggcctacaa cacggtcatc 27121 ggcaacagct acaccgcgtc ggtgtacctg gcgctggccg cgctgctcga ccaggccgac 27181 gacctgaccg gcaaggcgat cggcttcctc agctacggct ccggcagcgt cgccgagttc 27241 ttcgccggga ccgtcaccgc cggctaccgg gagaacctgc gcaccgacgc caaccgccgg 27301 gccatcgccc ggcgcacgcc ggtcgacctg gccggctacc gcgacctgca cgagcgctcg 27361 ttccccaccg acggcggcga ccacgccacc gagcggcaca ccaccggccc gttccggctg 27421 gccgggatca gcggccacaa gcgcctctac caggcgcgct agcggcacct cgcgggccgg 27481 atcgcgcggg cgggcaccct gagagccccg cccgcgcgat ccggccctgt catggccgcg 27541 tacctgccgg ccatccgcac aagccagtca ccgaccatac gaggggaggg cagccgcatg 27601 accgacgtca ggattctcgg tacgggtgcc tacgtgcccg accggatcgt ctccaacgac 27661 gaggtcggcg caccggccgg cgtcgacgac gcctggatca ccgccaaaac cgccatccgc 27721 gaacgccgct gggccgc //