LOCUS       NZ_LMEQ01000012        23369 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root1310 contig_2, whole genome shotgun sequence.
ACCESSION   NZ_LMEQ01000012
VERSION     NZ_LMEQ01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1310
  ORGANISM  Streptomyces sp. Root1310
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1120187)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 1120187)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1310
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426425.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 02:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,470
            CDSs (total)                      :: 8,385
            Genes (coding)                    :: 8,123
            CDSs (with protein)               :: 8,123
            Genes (RNA)                       :: 85
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 262
            CDSs (without protein)            :: 262
            Pseudo Genes (ambiguous residues) :: 0 of 262
            Pseudo Genes (frameshifted)       :: 98 of 262
            Pseudo Genes (incomplete)         :: 219 of 262
            Pseudo Genes (internal stop)      :: 20 of 262
            Pseudo Genes (multiple problems)  :: 64 of 262
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 961740
            Orig. end                         :: 985109
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEQ01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23369
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="4"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23369
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23369
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13369](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13369
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            116..1195
                     /locus_tag="ASD48_RS22440"
                     /old_locus_tag="ASD48_13980"
     CDS             116..1195
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131224.1"
                     /locus_tag="ASD48_RS22440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_13980"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_057603410.1"
                     /transl_table=11
                     /translation="MTRSAADGPAGPASRGRSRRNFAGSRPVMDDVAKLAGVSKQTVSR
                     VLNDHPAVRAETREAVRAAMRTLGYRPSSSARSLASGRTRMLGVISFDAARYGPASTLT
                     AINTAAQEAGYLVSSIALDTADRDTVVRAADRLSAEGADGVIAIAPQVRVARALAEAHL
                     DTPLVVMDNDLGDGTPMVTSDASTGARKATRHLLSLGHPTVHHLAGPAGWTSADRRAES
                     WRATLEAAGAEVHTPLIGDWSADSGYDLGRELAKDPSVTALFVSNDQMALGVLRALYEA
                     GRRVPEDVSVVGYDDIPEAAHFLPPLTTIRTDFTDIGTISLRILLNRIDSPSTPGSPLT
                     IVPVELCVRHSTARPRRPA"
     gene            complement(1326..2198)
                     /locus_tag="ASD48_RS22445"
                     /old_locus_tag="ASD48_13985"
     CDS             complement(1326..2198)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131223.1"
                     /locus_tag="ASD48_RS22445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_13985"
                     /product="ANTAR domain-containing protein"
                     /protein_id="WP_057603411.1"
                     /transl_table=11
                     /translation="MSQLSRHPAEGGSAADVSGSGSRQGSAPRWRQDDLDLRNRLYGRA
                     GVARAEGVLLDRYGLGSTDEAFALMKKASQQFNIKLSTLADAVVRTPAPDADAALWFPG
                     RVRRGPPALPGLPVERGKGTSQGAVLAAALERVLSITQTPMGNVQLSERGRLRLARHTG
                     LNRYFTDFFAFVDAPTTSCSQAAGQRRQVTVRDVESAPVFDEASRHAILQTGSRAAHSV
                     PLMNRRGVPLGMVSSHHERPLTGFTQPELAALRQTGSDVGRWLAWHWTTVVLDALEHLH
                     AAALRGPGD"
     gene            complement(2345..2470)
                     /locus_tag="ASD48_RS46015"
     CDS             complement(2345..2470)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS46015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_282438253.1"
                     /transl_table=11
                     /translation="MAVDTGPGGAALRHRAAIPRTRAVPYARAGQPGPRVAPHPL"
     gene            complement(2497..4122)
                     /locus_tag="ASD48_RS22450"
                     /old_locus_tag="ASD48_13990"
     CDS             complement(2497..4122)
                     /NRPS_PKS="Domain: Abhydrolase_1 (124-292). E-value:
                     1.4e-12. Score: 39.6. Matches aSDomain:
                     nrpspksdomains_ASD48_RS22450_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132081.1"
                     /locus_tag="ASD48_RS22450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_13990"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_057603412.1"
                     /sec_met_domain="PF00561 (E-value: 5e-17, bitscore: 58.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPGTTPSRRPARRLPATLAAATAGALVVGLAALPAHAGSGTAGP
                     IGTVARTVGDAHFEPGPCPRTADPIPDLARARCGTLTVPEKRSPAKGPKEPQGYGGGDG
                     RTITLAVAIMPAESSRPAPDPIVWLAGGPGDDAVSEIPMALGGHLNRDRDVIFMSQRGT
                     YSADPELTCPNIDRFNARALGLVSNAPSTGRLHVEATRACRARVDAKGADRSAYNDIES
                     SADYDALRKTLHVKKWNVFGISYGTHLALNYMRLHPKGIRSVGIDGILPPSIAGGAVTW
                     KAAREGFDGLFKACAQQPACDTRYPNLKATFLRLVSELEARPITTTVTVPVHPEPVKVV
                     LDGSNLVTWLTSATHVAAGVPRSIDELAHGNPQRIAEQLAGGKYSPQAIGRVAHGLVYG
                     IFCRQWTPYESRADIIRGGRRAFPTFPRSMLANAPQLAWLHDDCRAWDVPPAPPSVRDV
                     TRSDIPTLALSGGFDAQTAPSNGAYVARTLSRSTKITVPYVAHVVFADSRCAQTITTSF
                     FARPTAPDTGCLAGLQPPRFEIAP"
     aSDomain        complement(3247..3750)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS22450_Abhydrolase_1.1"
                     /evalue="1.40E-12"
                     /label="ASD48_RS22450_Abhydrolase_1.1"
                     /locus_tag="ASD48_RS22450"
                     /protein_end="292"
                     /protein_start="124"
                     /score="39.6"
                     /tool="antismash"
                     /translation="PIVWLAGGPGDDAVSEIPMALGGHLNRDRDVIFMSQRGTYSADPE
                     LTCPNIDRFNARALGLVSNAPSTGRLHVEATRACRARVDAKGADRSAYNDIESSADYDA
                     LRKTLHVKKWNVFGISYGTHLALNYMRLHPKGIRSVGIDGILPPSIAGGAVTWKAAREG
                     FDGLF"
     gene            complement(4136..5581)
                     /locus_tag="ASD48_RS22455"
                     /old_locus_tag="ASD48_13995"
     CDS             complement(4136..5581)
                     /NRPS_PKS="Domain: Abhydrolase_1 (64-224). E-value:
                     4.1e-15. Score: 48.0. Matches aSDomain:
                     nrpspksdomains_ASD48_RS22455_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888714.1"
                     /locus_tag="ASD48_RS22455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_13995"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_242432675.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-17, bitscore: 59.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAGGPPPGHPARFVPGPCPRTPDPVPGRCGFLEVPENRERPTGR
                     TIRLAVAIIPAASRTPAADPVVFMEGGPGGDAFGAIPFLIDSDVNRDRDLIVVAQRGTL
                     HSQPNLACPEMDRFNATAVGLPYDAPSTGRRLVRAAKECRDRLTAEGNDLSAYNTTENA
                     ADFAALRKALGIRKWNVYGYSYGTDLGLTYLRRHPQGIRSLAIDSVVPPQIVSLPWAWD
                     SAQEGINAIFAACEAQPACKSRYPHLSRTLTQQVRRLEAHPLTLTVPPPGGGTPVKVVL
                     DGGTLVNLLVANGGLVPAVDVPAALHELAAGNPERLARAQAAGATPAIGEFAHGLTHSV
                     ACAEWVPGFSKRDVLKAGRRAFPGWPDSVLAHAPQLPFEHDLCRVWNVPDRTAVQRLAT
                     HSKVPALIITGTFDAKTGASWGPFTGRTLPRSTAVVIPGITHWVVPQEPCAASVLVSFL
                     ARPTAPDTGCVPGVRPKPFTIVP"
     aSDomain        complement(4910..5389)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS22455_Abhydrolase_1.1"
                     /evalue="4.10E-15"
                     /label="ASD48_RS22455_Abhydrolase_1.1"
                     /locus_tag="ASD48_RS22455"
                     /protein_end="224"
                     /protein_start="64"
                     /score="48.0"
                     /tool="antismash"
                     /translation="PVVFMEGGPGGDAFGAIPFLIDSDVNRDRDLIVVAQRGTLHSQPN
                     LACPEMDRFNATAVGLPYDAPSTGRRLVRAAKECRDRLTAEGNDLSAYNTTENAADFAA
                     LRKALGIRKWNVYGYSYGTDLGLTYLRRHPQGIRSLAIDSVVPPQIVSLPWAWDSA"
     gene            6513..6746
                     /locus_tag="ASD48_RS22460"
                     /old_locus_tag="ASD48_14000"
     CDS             6513..6746
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.4"
                     /locus_tag="ASD48_RS22460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_14000"
                     /product="serine hydrolase"
                     /protein_id="WP_057603413.1"
                     /transl_table=11
                     /translation="MAVVVLASAITSKTVFDMASNSKQFTADAVLLLAGRHRLAVNDPL
                     SDYLDDPPARARDITLGASAEPHCSPVSRTER"
     CDS_motif       6513..6536
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAVVVLAS"
                     /locus_tag="ASD48_RS22460_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6537..6746
                     /prepeptide="core"
                     /locus_tag="ASD48_RS22460_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="7222.0"
                     /monoisotopic_mass="7217.8"
                     /core_sequence="AITSKTVFDMASNSKQFTADAVLLLAGRHRLAVNDPLSDYLDD
                     PPARARDITLGASAEPHCSPVSRTER"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAVVVLAS"
                     /leader_location="[6512:6536](+)"
                     /alternative_weights="7240.0"
                     /alternative_weights="7258.0"
                     /alternative_weights="7276.1"
                     /alternative_weights="7294.1"
                     /alternative_weights="7312.1"
                     /alternative_weights="7330.1"
                     /alternative_weights="7348.1"
                     /alternative_weights="7366.2"
                     /alternative_weights="7384.2"
                     /alternative_weights="7402.2"
                     /alternative_weights="7420.2"
     gene            6749..6973
                     /locus_tag="ASD48_RS22465"
                     /old_locus_tag="ASD48_14005"
     CDS             6749..6973
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS22465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ASD48_14005"
                     /product="hypothetical protein"
                     /protein_id="WP_057603414.1"
                     /transl_table=11
                     /translation="MGDVLRPRGIEEGRYGAGILLLPDKSLVHRGDWEGFHSTFKVSPD
                     RDTAVTVACNADPPDNFRAADRLLAIWTK"
     CDS_motif       6749..6799
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGDVLRPRGIEEGRYGA"
                     /locus_tag="ASD48_RS22465_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6800..6973
                     /prepeptide="core"
                     /locus_tag="ASD48_RS22465_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="6208.9"
                     /monoisotopic_mass="6205.2"
                     /core_sequence="GILLLPDKSLVHRGDWEGFHSTFKVSPDRDTAVTVACNADPPD
                     NFRAADRLLAIWTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGDVLRPRGIEEGRYGA"
                     /leader_location="[6748:6799](+)"
                     /alternative_weights="6227.0"
                     /alternative_weights="6245.0"
                     /alternative_weights="6263.0"
                     /alternative_weights="6281.0"
                     /alternative_weights="6299.0"
                     /alternative_weights="6317.1"
     misc_feature    6981..6995
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     gene            7036..7869
                     /locus_tag="ASD48_RS22470"
                     /old_locus_tag="ASD48_14010"
     CDS             7036..7869
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891844.1"
                     /locus_tag="ASD48_RS22470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_14010"
                     /product="DUF4436 family protein"
                     /protein_id="WP_057603586.1"
                     /transl_table=11
                     /translation="MPVLIPIAFLIVVAVGVGSWLQFTERQAADTVHTAGSSAADRVDV
                     EAVVQSVDAVGRELVLRVWVTPRGTLGEADGAAPVADLSLQTSGATLSDLEFAAHERLA
                     TRDVQVALTGGSISDYPFDTYETDIAFRAQLGGKQVPVRMLFSNNDTLFSISAQPAPSR
                     QEAVLALGLARSGSLLVFAVFMMVVMWALAASVLIGAWYLTTGSEGLVWPGLAWMAATL
                     FALAAFRNTAPGTPPIGCVLDWFAFLWAETIIALCLITVVVTGVNKALHQDTPRT"
     gene            complement(7990..8244)
                     /locus_tag="ASD48_RS22475"
                     /old_locus_tag="ASD48_14015"
     CDS             complement(7990..8244)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS22475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ASD48_14015"
                     /product="hypothetical protein"
                     /protein_id="WP_057603415.1"
                     /transl_table=11
                     /translation="MPQEQCQAAKAKLEQAKQRRKRLQRDLTEDEAKLAHLKAEPHPDA
                     AAIEAQERMVEIDRRVLGAAEVEVTGFEELVHALCDDLP"
     CDS             9162..9335
                     /gene="allorf_0970902_0971075"
                     /locus_tag="allorf_0970902_0971075"
                     /protein_id="allorf_0970902_0971075"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MICIGVRATVRHYGVGVHPLAPYTGSNGRCTSLGSRVPCSVGGSG
                     AYTADSARSATP"
     CDS_motif       9162..9266
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MICIGVRATVRHYGVGVHPLAPYTGSNGRCTSLGS"
                     /locus_tag="allorf_0970902_0971075_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9267..9335
                     /prepeptide="core"
                     /locus_tag="allorf_0970902_0971075_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="2002.1"
                     /monoisotopic_mass="2001.0"
                     /core_sequence="RVPCSVGGSGAYTADSARSATP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MICIGVRATVRHYGVGVHPLAPYTGSNGRCTSLGS"
                     /leader_location="[9161:9266](+)"
                     /alternative_weights="2020.2"
                     /alternative_weights="2038.2"
                     /alternative_weights="2056.2"
                     /alternative_weights="2074.2"
                     /alternative_weights="2092.2"
     CDS             complement(9197..9361)
                     /gene="allorf_0970937_0971101"
                     /locus_tag="allorf_0970937_0971101"
                     /protein_id="allorf_0970937_0971101"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRNTGAFTRYGVALLAESAVYAPLPPTEHGTRLPREVHRPFDPVY
                     GARGCTPTP"
     CDS_motif       complement(9221..9361)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRNTGAFTRYGVALLAESAVYAPLPPTEHGTRLPREVHRPFDPVYGA"
                     /locus_tag="allorf_0970937_0971101_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9197..9220)
                     /prepeptide="core"
                     /locus_tag="allorf_0970937_0971101_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="694.8"
                     /monoisotopic_mass="694.3"
                     /core_sequence="RGCTPTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRNTGAFTRYGVALLAESAVYAPLPPTEHGTRLPREVHRPF
                     DPVYGA"
                     /leader_location="[9220:9361](-)"
                     /alternative_weights="712.8"
     CDS             complement(9279..9401)
                     /gene="allorf_0971019_0971141"
                     /locus_tag="allorf_0971019_0971141"
                     /protein_id="allorf_0971019_0971141"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTTAGCLQRRTYLVAQHRRVHALWGGASCRIGSVCTAPAN"
     CDS_motif       complement(9324..9401)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTTAGCLQRRTYLVAQHRRVHALWGG"
                     /locus_tag="allorf_0971019_0971141_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9279..9323)
                     /prepeptide="core"
                     /locus_tag="allorf_0971019_0971141_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.10"
                     /molecular_weight="1295.5"
                     /monoisotopic_mass="1294.6"
                     /core_sequence="ASCRIGSVCTAPAN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTTAGCLQRRTYLVAQHRRVHALWGG"
                     /leader_location="[9323:9401](-)"
                     /alternative_weights="1313.5"
     gene            9518..9748
                     /locus_tag="ASD48_RS41350"
     CDS             9518..9748
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03898.1"
                     /locus_tag="ASD48_RS41350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_063887479.1"
                     /transl_table=11
                     /translation="MSLRKIVRAWEDPKYRDSLSDPELADLPDNPAGVIELTDAELGQV
                     LGGAQSGNSVGCNTKTCVSTRGNSQNPCRNC"
     CDS_motif       9518..9661
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSLRKIVRAWEDPKYRDSLSDPELADLPDNPAGVIELTDAELGQVLGG"
                     /locus_tag="ASD48_RS41350_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9662..9748
                     /prepeptide="core"
                     /locus_tag="ASD48_RS41350_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.20"
                     /molecular_weight="2761.0"
                     /monoisotopic_mass="2759.2"
                     /core_sequence="AQSGNSVGCNTKTCVSTRGNSQNPCRNC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLRKIVRAWEDPKYRDSLSDPELADLPDNPAGVIELTDAE
                     LGQVLGG"
                     /leader_location="[9517:9661](+)"
                     /alternative_weights="2779.0"
                     /alternative_weights="2797.0"
                     /alternative_weights="2815.1"
     CDS             9885..10004
                     /gene="allorf_0971625_0971744"
                     /locus_tag="allorf_0971625_0971744"
                     /protein_id="allorf_0971625_0971744"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTPRSGINETRRGLLGAVQQPSSTCRAEQRVEFEGTART"
     CDS_motif       9885..9935
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTPRSGINETRRGLLGA"
                     /locus_tag="allorf_0971625_0971744_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9936..10004
                     /prepeptide="core"
                     /locus_tag="allorf_0971625_0971744_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.60"
                     /molecular_weight="2390.6"
                     /monoisotopic_mass="2389.2"
                     /core_sequence="VQQPSSTCRAEQRVEFEGTART"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTPRSGINETRRGLLGA"
                     /leader_location="[9884:9935](+)"
                     /alternative_weights="2408.6"
                     /alternative_weights="2426.6"
                     /alternative_weights="2444.6"
                     /alternative_weights="2462.6"
     gene            10001..13369
                     /locus_tag="ASD48_RS22485"
                     /old_locus_tag="ASD48_14025"
     CDS             10001..13369
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="ASD48_RS22485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_14025"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_079073904.1"
                     /sec_met_domain="DUF4135 (E-value: 1.5e-111, bitscore:
                     369.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-60, bitscore:
                     201.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAEEVWQAPEWYRAFSLLERGDRGDRSSDGRDRGDRGDTPSIRP
                     TETSYASDLLLEGAPGRLKAWKSQKPFERRPLFAQRLAQDSLSESDLLALLAEHPESLK
                     TRVQATPDWLTVLRQAFTHPDSAERAEEWAPLLEKAEADHPLAAGLLAVGPLLWHFFDR
                     LQERIRGLREEVGFLPFDMKKLPGVYLANLAPLILFQLSKPILLELHVARLEGRLEGGT
                     AEERFEDFFRRLRQEGSIVAVLAKYPVLARQLVLTTEQWADYLYEFLTHLCADWQSVRA
                     AFAPGGDPGPLVDVEAGKGDRHRKGRSVLLLRFGSGMKLLYKPRSLGVDVHFQELLSWL
                     DDRGAEPALRPLKLVDCGDHGWSEFVEATPCTCEEEIVRFYERQGSYLALLYVLDAADL
                     HNENLLAAGEHPMLVDLEALFHPHVHAEGPALGNLAVGALDRSVWQVGLLPRRVWSDQN
                     SIGVDMSGLGGQPGQTNPHRLVSWERPGTDEMRVGRRRTELPVSENRPRLGDQDVEVWK
                     YQDAVLAGFAGMYRLIRENRAALLAEQLPRFAHDETRVVIRSTNVYGLLWYESFHPDLL
                     RDALDRDRFFDHLWIEAAQRPCLVPLIPAEKRDLWHGDIPLFHTSPGSRAVLTAEGERW
                     EDFLDAPSLDLVRQRVERLGDDDLAKQSWIIKASLATLLMDPEDRINRPAQVPSTHRPS
                     PVTGRVPREQLLALASSVGRRLDELSLQNERGAYWLGVGPLDESAWGLFPSGSDLYSGT
                     SGIALFLGYLGAITDEPSATLLARRALTSARTQVREWLREEPDPGGSAPTVGAFDGLAS
                     VVYVLTSLGVLWAEQDLLDEAAELAERLPPLISGDLSLDVIYGSAGCALSLLSLHAVRP
                     SPRTLDVAVRCGERLLARARPVHRGTAWTTLEDQPPLGGFSHGTAGIALSLLRLAARSG
                     EDRFRRTALSALRYDRSLFVPELNNWADLRVFEPRTGRADPVESAVEPPRKSMVAWCHG
                     APGIGLARLAALDQLADATTRDEIDVALTATEQYGFAMGHSLCHGALGNLELLLTAARS
                     LDRPADHDALERATALVVASMRTDGFVTGVPLGVETPGLMTGLAGIGYELLRLAEPDKV
                     PSVLLLAPPRWQAPG"
     gene            13388..13963
                     /locus_tag="ASD48_RS22490"
                     /old_locus_tag="ASD48_14030"
     CDS             13388..13963
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS22490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ASD48_14030"
                     /product="hypothetical protein"
                     /protein_id="WP_057603417.1"
                     /transl_table=11
                     /translation="MPHRVIFRQSAVQAYRRGTAKDIVPRLTFRPVIVCLWLLLAVLIA
                     AAALAWTVRVPAYVSAQGTILPNDARAGPGGGTTQAALFLPADRSADVRVGRPVHAQIG
                     SSGPSVSGSVVRVEPGVIGPDTARAVYRFEPGAGTVRQPWTVVIVRLGPSLRPSAYDGS
                     LLTARVEAGSQRLLTLFPGWGESVGGAA"
     gene            14080..16299
                     /locus_tag="ASD48_RS22495"
                     /old_locus_tag="ASD48_14035"
     CDS             14080..16299
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="ASD48_RS22495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_14035"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_063887480.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-36, bitscore:
                     121.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGRTRKAHRGTHRRRVPEVRQMSEVECGLACLTMMLNYHGCGTS
                     LSEMRTRCGVGRDGLSALEIVRIARDHGMRVRTVSLPRNDLRFVALPAIVHWEFTHFLV
                     VERWSRDHVDVVDPARGRCRLTADEFDAGFTGVVILLEPGAAFDRRAAAPPRATFRVYI
                     LQFLRQAPGTSLQLLGVSLLLILLGLVLPILTGVVVDQVLPFRLDDVMPVLGIGIVAIF
                     VAQTVATLLREWLLVFLRARIDVSMMLGFVEHLFELPYKYFQQRSTGDLLARAASNAML
                     RELLSNQLLSAVMDSGLVTLYLLLLFWQSPPFGALTLGVGLVGALVLMLSQGTISRLSG
                     RELAAFGKSQGYLGEAIVGIGTLKAAGAETQAFDRWSNLFFDHLNISLRHSYVSGTVAS
                     ILGSLPLFGQLGLLWVGATQVLDGSISVGTMVALLALAAAFFAPLTSLVASAQQFQLVS
                     ANLDRIRDVTEAEPEQVRQVSRPVPRLTGHLRMDRVGFRYSQTGPQVLRDIDMTARPGE
                     RIAIVGLSGSGKSTLGKLLLGLYVPTQGDILYDGLSLRDVTWQELRRQFGVVLQESALF
                     SGSILSNIALSNPSIKRERVVAAAELAAIHDDIMAMPMQYDTFVSEGGSALSGGQRQRL
                     AIARAIAHKPAIIMLDEATSHLDVETERRVAENLRTLACTQIIIAHRLSTIRDADLILV
                     LDQGTIVERGSHHDLLRRAGHYARLVGQQLESSDEARPLPGAPDR"
     gene            complement(16868..17446)
                     /locus_tag="ASD48_RS22500"
                     /old_locus_tag="ASD48_14040"
     CDS             complement(16868..17446)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004933681.1"
                     /locus_tag="ASD48_RS22500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_14040"
                     /product="suppressor of fused domain protein"
                     /protein_id="WP_057603419.1"
                     /transl_table=11
                     /translation="MSDARLPAAEAVESHVRAFFVGHSVEAVDYDLGPERRAALPALRV
                     LVVEPGPRSDSWAYVTAGCWAPMEKHGNGLEFVMTAHVRDQRFIELMAMIAYYHCGGHP
                     LDLEHSMPIGEPWVPGSTCDHLLISLPYLHGPDLEHCPLPGGHVRILWTLPVTAAEIEF
                     RRQHGHEALEQLFDEAQIIPTDPFRVSVA"
     CDS             complement(17576..17791)
                     /gene="allorf_0979316_0979531"
                     /locus_tag="allorf_0979316_0979531"
                     /protein_id="allorf_0979316_0979531"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCAGSNPAGGALHEVPKGPATSAFAEDGVLAYVQACAARSGRMSG
                     AWDCAWTGRRPGISRSTPGNDATPGP"
     CDS_motif       complement(17717..17791)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCAGSNPAGGALHEVPKGPATSAFA"
                     /locus_tag="allorf_0979316_0979531_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17576..17716)
                     /prepeptide="core"
                     /locus_tag="allorf_0979316_0979531_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.40"
                     /molecular_weight="4624.0"
                     /monoisotopic_mass="4621.2"
                     /core_sequence="EDGVLAYVQACAARSGRMSGAWDCAWTGRRPGISRSTPGNDAT
                     PGP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCAGSNPAGGALHEVPKGPATSAFA"
                     /leader_location="[17716:17791](-)"
                     /alternative_weights="4642.1"
                     /alternative_weights="4660.1"
                     /alternative_weights="4678.1"
                     /alternative_weights="4696.1"
                     /alternative_weights="4714.1"
     CDS             17730..17939
                     /gene="allorf_0979470_0979679"
                     /locus_tag="allorf_0979470_0979679"
                     /protein_id="allorf_0979470_0979679"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAGPLGTSCKAPPAGFEPAHTAPEAVENHYVIAGQAFSLACRGEV
                     RPQLVHRERSPDRPVRLLAGSTPT"
     CDS_motif       17730..17831
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAGPLGTSCKAPPAGFEPAHTAPEAVENHYVIAG"
                     /locus_tag="allorf_0979470_0979679_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17832..17939
                     /prepeptide="core"
                     /locus_tag="allorf_0979470_0979679_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.90"
                     /molecular_weight="3811.3"
                     /monoisotopic_mass="3809.1"
                     /core_sequence="QAFSLACRGEVRPQLVHRERSPDRPVRLLAGSTPT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAGPLGTSCKAPPAGFEPAHTAPEAVENHYVIAG"
                     /leader_location="[17729:17831](+)"
                     /alternative_weights="3829.3"
                     /alternative_weights="3847.4"
                     /alternative_weights="3865.4"
                     /alternative_weights="3883.4"
     misc_feature    17742..17758
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     tRNA            complement(17761..17848)
                     /anticodon=(pos:complement(979537..979539),aa:Arg,seq:ccg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="ASD48_RS44300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Arg"
     gene            complement(17761..17848)
                     /locus_tag="ASD48_RS44300"
     gene            17936..18079
                     /locus_tag="ASD48_RS44305"
     CDS             17936..18079
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASD48_RS44305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157880664.1"
                     /transl_table=11
                     /translation="MSAPVLPWRPEAVGALAVRGPATSHCQSWGPESWRGVRAARYEIQ
                     VD"
     CDS             18148..18252
                     /gene="allorf_0979888_0979992"
                     /locus_tag="allorf_0979888_0979992"
                     /protein_id="allorf_0979888_0979992"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGCYGGAQGAHSLGGVPHWSQLIRQNCFRFLRGS"
     CDS_motif       18148..18192
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGCYGGAQGAHSLGG"
                     /locus_tag="allorf_0979888_0979992_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18193..18252
                     /prepeptide="core"
                     /locus_tag="allorf_0979888_0979992_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.60"
                     /molecular_weight="2308.7"
                     /monoisotopic_mass="2307.2"
                     /core_sequence="VPHWSQLIRQNCFRFLRGS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGCYGGAQGAHSLGG"
                     /leader_location="[18147:18192](+)"
                     /alternative_weights="2326.7"
     misc_feature    18454..18469
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.68"
                     /tool="antismash"
     misc_feature    complement(18490..18503)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.62"
                     /tool="antismash"
     CDS             18536..18730
                     /gene="allorf_0980276_0980470"
                     /locus_tag="allorf_0980276_0980470"
                     /protein_id="allorf_0980276_0980470"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVCAPGGGSGGGLGRFIDPAVTHEETRLRAAGAGRTTPAARSIQG
                     RCRRLPLPGKSALPQWLGV"
     CDS_motif       18536..18634
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MVCAPGGGSGGGLGRFIDPAVTHEETRLRAAGA"
                     /locus_tag="allorf_0980276_0980470_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18635..18730
                     /prepeptide="core"
                     /locus_tag="allorf_0980276_0980470_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3271.8"
                     /monoisotopic_mass="3269.9"
                     /core_sequence="GRTTPAARSIQGRCRRLPLPGKSALPQWLGV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVCAPGGGSGGGLGRFIDPAVTHEETRLRAAGA"
                     /leader_location="[18535:18634](+)"
                     /alternative_weights="3289.8"
                     /alternative_weights="3307.9"
                     /alternative_weights="3325.9"
     CDS             complement(18597..18803)
                     /gene="allorf_0980337_0980543"
                     /locus_tag="allorf_0980337_0980543"
                     /protein_id="allorf_0980337_0980543"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTSRIHFRDQPNVSMLQRADVQGGLIPQAIEARPTSLEAEAFDID
                     PVWTALREWSCQPQRRAAGSPRV"
     CDS_motif       complement(18732..18803)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTSRIHFRDQPNVSMLQRADVQGG"
                     /locus_tag="allorf_0980337_0980543_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18597..18731)
                     /prepeptide="core"
                     /locus_tag="allorf_0980337_0980543_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.60"
                     /molecular_weight="4843.4"
                     /monoisotopic_mass="4840.5"
                     /core_sequence="LIPQAIEARPTSLEAEAFDIDPVWTALREWSCQPQRRAAGSPR
                     V"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTSRIHFRDQPNVSMLQRADVQGG"
                     /leader_location="[18731:18803](-)"
                     /alternative_weights="4861.4"
                     /alternative_weights="4879.5"
                     /alternative_weights="4897.5"
                     /alternative_weights="4915.5"
     misc_feature    19095..19108
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    19552..19561
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    22295..22310
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.16"
                     /tool="antismash"
     misc_feature    22839..22858
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.81"
                     /tool="antismash"
ORIGIN
        1 ggcggctcgg cacgacctga cccgcgcttc ctcgggcgcc cggcctatcc tgtgggtccg
       61 ccgggcggcc cagcgcgacc ggccccggac cagtcccgag gaagaagccc ccaccatgac
      121 ccgaagcgcc gccgacggcc ccgccggccc ggcgtccagg ggacgcagca gacgcaactt
      181 cgcgggctca cgtccggtca tggacgacgt cgcgaaactg gccggagtct ccaaacagac
      241 ggtctcccgg gtgctcaacg accatccggc cgtccgcgcc gagacccggg aagcggtccg
      301 ggcggcgatg cgcaccctcg gctaccgccc cagcagcagc gcccgctcgc tggccagcgg
      361 ccgtacccgc atgctcggcg tgatctcctt cgacgcggcc cgctacggtc ccgcctccac
      421 cctgaccgcc atcaacacgg cggcgcagga agccggttac ctggtgagct cgatcgcgct
      481 ggacaccgcg gaccgggaca cggtggtacg ggccgcggac cggctgtcgg cggagggcgc
      541 ggacggtgtc atcgcgatcg ccccccaggt ccgggtggcc cgcgcgctcg ccgaggccca
      601 cctcgacacg cccctggtgg tcatggacaa cgacctgggt gacggcaccc ccatggtcac
      661 ctcggacgcc agcaccggcg cccgcaaggc cacgcggcac ctcctctccc tcggccaccc
      721 cacggtccac cacctggcgg gcccggcggg ctggacctcg gcggaccgcc gggcggagag
      781 ctggcgcgcc accctcgagg cggccggagc cgaggtgcac acccccctca tcggcgactg
      841 gagcgccgac tccggctacg acctcggccg cgaactggcg aaggacccgt ccgtcaccgc
      901 gctcttcgtc tccaacgacc agatggccct cggcgtcctg cgggccctgt acgaggcggg
      961 ccgccgggtc ccggaggacg tcagcgtcgt cggctacgac gacatccccg aagccgccca
     1021 cttccttccc ccgctgacca cgatccgtac ggacttcacg gacatcggca cgatctccct
     1081 ccgcatcctg ctgaaccgca tcgacagccc gtcgaccccc ggaagcccgc tcacgatcgt
     1141 ccccgtcgag ctgtgcgtcc gccacagcac cgcccgccca cgccgaccgg cctgaccggc
     1201 ctgaccggcc tgaccggcct gaccggcctg accggtccga ccggcctgac cggtccgacc
     1261 ggcccgaccg gtccgaccgg cccgaccggt ccgaccggct caccggcccg accgacccac
     1321 cgggctcaat cgcccgggcc ccgcaaggcg gcggcgtgga gatgctccag ggcgtccagc
     1381 acgacggtgg tccagtgcca ggccagccac cggccgacat cgctgccggt ctgccggagc
     1441 gcggccagct cgggctgggt gaagccggtc agcggccgct cgtgatggga ggacaccatt
     1501 cccagcggca cgccccgccg gttcatcagc ggcacgctgt gcgcggcccg actgcccgtc
     1561 tggaggatgg cgtggcggga ggcctcgtcg aacaccggcg ccgactccac gtcccgcacg
     1621 gtgacctgcc gacgctggcc ggccgcctgc gagcaggagg tggtcggggc gtcgacgaag
     1681 gcgaagaagt cggtgaagta cctgttcagg ccggtgtgcc gggccagccg gagccggccc
     1741 ctctcgctca gctggacatt gcccatgggc gtctgggtga tcgacagcac ccgttccagg
     1801 gccgccgcga ggacagcgcc ctggctggtg cctttgccac gctcgaccgg gagcccggga
     1861 agcgcgggcg ggccgcgccg cacccggccg gggaaccaca gtgcggcgtc ggcatcgggc
     1921 gccggtgtgc ggacgacggc gtcggcgagg gtggagagct tgatgttgaa ctgctgggag
     1981 gccttcttca tcagggcgaa cgcctcatcg gtggagccga gaccgtagcg gtcgagcagc
     2041 accccttcgg cgcgggcgac cccggcgcgg ccgtacagac ggttgcgcag atcgagatcg
     2101 tcctgccgcc accgcggtgc gcttccctgg cgggacccgg agccggacac atcggctgcc
     2161 gagcctcctt cggcagggtg ccgggacagc tggctcatac caagggctcc aatccgggat
     2221 gggtccggtc gacggacgag ggtgaacccg gcgggcgctc cccggccggc cggggcatac
     2281 ctccttacca agcactgcca tcgcctaacc ggaagcccgc cgggtaaacc cgccggcttc
     2341 cgcgtcacag cgggtgcggg gcgacgcgcg ggccgggctg cccggcccgc gcgtacggca
     2401 cggctctcgt cctggggatc gcggcccggt gccgcagggc cgcaccgccg gggcccgtgt
     2461 ccaccgccac ggtggacacg ggccccggcg agcgccctac ggtgcgatct cgaaccgcgg
     2521 cggctggagt cccgccaggc agccggtgtc cggcgcggtc ggacgggcga agaacgacgt
     2581 ggtgatcgtc tgcgcgcacc gcgagtcggc gaacaccacg tgggcgacgt aagggaccgt
     2641 gatcttggtg gagcggctca gcgtacgggc gacgtaggcc ccgttgctcg gcgccgtctg
     2701 ggcgtcgaac ccgccggaca gggcgagggt cgggatgtcg ctgcgggtca cgtcccggac
     2761 cgacgggggc gccgggggga cgtcccaggc ccggcagtcg tcgtggagcc aggcgagttg
     2821 cggggcgttg gccagcatcg accgggggaa cgtcgggaac gcgcggcggc cgccgcggat
     2881 gatgtcggcc cggctctcgt acggggtcca ctggcggcag aagatgccgt agaccagccc
     2941 gtgggcgacc cttccgatgg cctgcgggct gtacttgccg cccgcgagct gctcggcgat
     3001 ccgctgcggg ttgccgtggg ccagttcgtc gatggaccgc ggcaccccgg ccgccacatg
     3061 ggtcgccgag gtcagccagg tgaccaggtt gctcccgtcc agcacgacct tcaccggctc
     3121 cgggtggacc gggaccgtga cggtggtggt gatcggcctg gcctccagct cactgacgag
     3181 gcggaggaag gtggccttga ggttcgggta gcgcgtgtcg caggcgggct gctgcgcgca
     3241 ggccttgaac aggccgtcga aaccttcgcg tgcggccttc caggtcacgg ccccgccggc
     3301 gatggacggc ggcaggatgc cgtcgatgcc gaccgagcgg atgcccttcg ggtgcaggcg
     3361 catgtagttg agcgccaggt gggtgccgta ggagatgccg aagacgttcc acttcttgac
     3421 gtgcagcgtc ttgcgcagtg cgtcgtagtc ggccgagctc tcgatgtcat tgtaggcgct
     3481 gcggtcggcg cccttggcgt ccacgcgggc gcggcaggcc cgggtcgcct cgacgtgcag
     3541 gcgcccggtg gacggcgcgt tggagacgag gccgagggcg cgggcgttga accggtcgat
     3601 gttcgggcag gtgagctccg ggtcggccga gtaggtgccg cgctgggaca tgaagatcac
     3661 gtcgcggtcg cggttcaggt ggccgccgag cgccatcggg atctcggaga ccgcgtcgtc
     3721 gccgggaccg ccggcgagcc acacgatcgg gtcgggcgcg gggcggctgc tctcggcggg
     3781 catgatcgcg acggcgaggg tgatcgtgcg tccgtcgccg cccccgtatc cctggggctc
     3841 cttgggcccc ttggccgggg agcgcttctc gggcacggtg agggtgccgc agcgggcgcg
     3901 tgcgagatcg gggatcgggt ccgccgtcct ggggcagggg cccggttcga agtgggcgtc
     3961 gcccaccgta cgggcgaccg tgccgatcgg gccggcggtg ccggacccgg catgcgcggg
     4021 cagcgcggcg aggccgacga cgagggcgcc ggccgtggct gcggccagcg ttgccgggag
     4081 ccgtcgagcg gggcgccggc tgggggtcgt accaggggac atcgtgcaac tccggtcagg
     4141 ggacgatggt gaacggtttg ggtcggactc ccggcacgca gccggtgtct ggcgcggtcg
     4201 gccgcgccag gaaggagacc aggaccgacg cggcgcaggg ctcctggggc accacccagt
     4261 gggtgattcc gggaatcacc accgcggtcg agcggggcag cgtccggccg gtgaacggcc
     4321 cccagctcgc cccggtcttg gcgtcgaagg ttccggtgat gatgagcgcg ggcaccttgc
     4381 tgtgggtggc cagccgctgg accgcggtgc ggtccgggac gttccagacc cggcacaggt
     4441 cgtgctcgaa gggcagctgc ggtgcgtggg ccagcaccga gtccggccat ccggggaagg
     4501 cccggcgacc cgccttcagc acgtcgcgct tcgagaagcc cgggacccac tcggcgcagg
     4561 ccaccgagtg cgtcagcccg tgggcgaact cgccgatggc gggcgtcgcg ccggcggcct
     4621 gggcccgcgc gaggcgctcc ggattgccgg cggcgagttc gtggagcgcc gcggggacgt
     4681 cgaccgccgg taccagtccg ccgttcgcga ccagcaggtt caccagcgtg cccccgtcga
     4741 ggacgacctt caccggggtt ccgccaccgg gcggcggtac ggtcagcgtc agggggtgcg
     4801 cctccagccg ccggacctgc tgcgtgagcg tgcgcgagag gtgcgggtag cgggacttgc
     4861 aggcgggctg ggcctcacac gccgcgaaga tcgcgttgat gccctcctga gcgctgtccc
     4921 aggcccacgg caggctcacg atctgtggcg gcacgaccga gtcgatcgcc agcgagcgga
     4981 tgccctgggg gtgtcggcgc aggtaggtga ggcccaggtc ggtgccgtag gagtagccgt
     5041 agacgttcca cttcctgatg cccagggcct tgcggagagc ggcgaagtcc gccgcgttct
     5101 cggtggtgtt gtaggccgag aggtcgtttc cctcggccgt caggcggtcc cggcactcct
     5161 tcgccgcgcg taccagccgt cgtccggtgg acggcgcgtc gtagggcaga ccgacggcgg
     5221 tcgcgttgaa ccggtccatc tccgggcagg cgaggttcgg ctgtgagtgg agggtgccgc
     5281 gctgggccac gacgatcaga tcgcggtcgc ggttcacgtc ggagtcgatc aggaagggga
     5341 tggctccgaa cgcgtctccg ccgggaccgc cttccatgaa cacgacgggg tccgcggccg
     5401 gcgtcctcga cgctgccggg atgatggcga cggccagccg gatggtccgt ccggtggggc
     5461 gctcgcggtt ctcggggacc tccaggaagc cgcaccgccc gggaaccggg tcgggcgtcc
     5521 ggggacaggg gcccggcacg aaccgcgccg gatgcccggg cggcggcccg ccggcaggca
     5581 tcgaccgggc gctgctcggc gcggtgccga cggcgccgaa cacacccaga caggcggcga
     5641 ggagcgccgc gttcgtacgt gctcgccggc tgagtcgcgg acgggagtgt cgagcccggc
     5701 tccgtacggg tgcccccgcc ccggaaaggg agggcagggg cccgggaccg atgtcgtgtt
     5761 ccgccatgtg atctcgtctc tctgacgtcc ctggccactc cggtcggggg acggttggca
     5821 tggctgcgcc ccaccgcacg gacgggcagg gcgcgtacgt cagcctgctt tcgggccggg
     5881 gcatccacca ctcgtcgcct ccacttggag cagccccgcc tcggaccgga cgctgtcccc
     5941 gctcgcccgc tcgcccgctc gcccgctcgc ccgctcgccc gctcgcccgc tcgcccgctc
     6001 gcccgctcgc ccgctcgccc gctcgcccgc tcggctcgcc tggtaacccc gggcggagtc
     6061 accgctccgg cagcgctccc tcggccgtat gcccggggcc ggcggcgcgc gccccgtcgc
     6121 cgccacgtcg tccgcatgca cgtcctcgga ccagcccgta gcgtggatta cgtgcggtcc
     6181 gccgacactg cccaggcgtc gcccgggagg ccccgtggca ttcggctgag gccgcgtggc
     6241 cgtcggcagg ggtacgggat cacagggatc acatgccggg gcgcggctgc cgcatcacgg
     6301 cacaccggca gtggcgcgcg ggccgcggca caccggcatc ggcgcgcggg cagcggactt
     6361 gatggcctcg cccctcggac gtcacccctc cgacgtcacc ctccgacgtc ccagccggcg
     6421 ctgagccgat cccgttaggt ggcgacagca ggtggcgaaa gcaggtggtt tccgtgactc
     6481 ggatggcgtc gttgtgtgcc gccgggggcg ccatggctgt ggtcgtactg gccagcgcca
     6541 tcacctcgaa gacggtcttc gacatggcct ccaattccaa gcaattcacc gcggacgcgg
     6601 tcctgttgct ggccgggcgg caccgactcg cggtgaacga ccccctgtcc gactacctcg
     6661 acgaccctcc ggcccgggcg cgggacatca cgctgggcgc atcggcggaa ccgcactgct
     6721 cgccggtgtc acggacggag cggtgaacgt gggcgacgtc ctgcgcccgc gcggcatcga
     6781 ggaagggcgc tacggggccg gaatcctcct cctccccgac aagagcctgg tgcatcgcgg
     6841 cgactgggag ggattccaca gcaccttcaa ggtgagcccg gaccgcgaca ccgccgtcac
     6901 cgtcgcgtgc aacgcggacc cacccgacaa cttccgtgcg gcagaccgac tgctggccat
     6961 ctggaccaag tgatgcgtca gggccgtccg gcacctgccg gctcccctcg cccacgacgt
     7021 tccgggcggt ccctcctgcc cgtgctcatc cctatcgcgt tcctgatcgt ggtggcggtg
     7081 ggcgtcggct cgtggctgca gttcaccgag cggcaggcgg ccgacacggt gcacaccgcc
     7141 ggatcctcgg ccgccgaccg ggtggacgtg gaggccgtcg tacagagtgt cgacgccgtg
     7201 ggcagggagc tggtactgcg ggtgtgggtg accccgcgcg ggaccctcgg cgaggcggac
     7261 ggggcggccc cggtggccga tctcagcctc cagacctcgg gggcgacgct cagcgacctg
     7321 gagttcgcgg cgcacgagcg gctcgccacg agagacgtgc aggtcgcgct caccggcgga
     7381 tcgatcagcg actatccgtt cgacacctac gagaccgaca tcgcgttccg cgcgcagctg
     7441 ggcggcaagc aggtgccggt acggatgctg ttctccaaca acgacacgct cttctcgatc
     7501 tcggcgcagc ccgcgccctc ccggcaggag gccgtgctgg cgctggggct ggcgcgatcg
     7561 ggcagtctgc tcgtcttcgc ggtcttcatg atggtggtga tgtgggcgct ggcggcgtcc
     7621 gtgctcatcg gggcctggta cctgacgacc ggcagcgagg gccttgtctg gcccggcctc
     7681 gcctggatgg ccgccaccct gttcgccctc gccgcgttcc gcaacaccgc ccccggcaca
     7741 cccccgatcg gctgcgtgct ggactggttc gccttcctgt gggccgagac catcatcgcc
     7801 ctctgcctga tcaccgtggt cgtcaccggc gtcaacaagg ccctccacca ggacacgccg
     7861 cgcacgtagt ggccgcgcca ggacatgccg cccacgtagt ggccgcgcgg caccgttccc
     7921 cgacggcggg ccggccacgc ccgcggtcag gccgccgtga gggcgctcga cgcgtcctgg
     7981 gcggcatgac tacggcaggt cgtcgcagag ggcgtggacc agctcctcaa agccggtgac
     8041 ctcaacttcg gccgctccga gaacgcgtcg gtcgatttcg accatgcgct cctgggcctc
     8101 gatcgccgca gcgtccggat gcggttccgc cttcaagtgg gcgagcttcg cttcgtcctc
     8161 cgtcaggtcc ctctgcaggc gcttccttcg ctgcttcgcc tgctcgagtt tggctttggc
     8221 cgcctgacac tgttcctgag gcatggtgct ccctagccgt gcgacgttgc ttcagcctta
     8281 cgggccggca gtcggcgcgc acgtcggctt ggcccaagtg ggcgtctcgc cgggccgcca
     8341 cgggcggacc cgctacgcga aatcggtacg gctcacgcgc gcgagcagcg acgtctccat
     8401 cagccccgat gagcgccgac ctgtagcaga gcgggaccca gtgagaatgg acccgcttct
     8461 cggattttct tcggtgggag tattttgctg tttcgatccc tgatcccctt ggtttctgta
     8521 cgtgggactc gcgaggaatc ggattcagca actccgcgat ccagtgattc agccattccg
     8581 cgatccagcg attccgcgag ttcggtggaa ttcgtgcggt caaggatggt gaacgggcct
     8641 tctcgtcact cacgccgaac ccggctcagc ttcaccgtcc gatggacggt ggccgctggg
     8701 cccctcactc atggaagtgg cccggaccat gccggtgacc gggcgccttg cgtcctggcc
     8761 acctcgtgac acgcgcttcc gtggcccgag cccgggaagc tccccctctg cgcaggtttc
     8821 ctggtcagct gggcgacgag cgttccatga cccggcggcg gtggagcagg gcgccaagcc
     8881 ctggacgaca tcgaccgacc ggcccgccgg gggacggccg cgtccggtga tcgacagcgg
     8941 attcggcccg ggcgacttcc gcggctacgc ccgtctcgcc tcaagggagg cggctgctcg
     9001 gagaccgagg cccattcggt gcgggcgagc tcattgaccg cgaaacagtt gaccgcaaaa
     9061 caaggtcccc gtcccgaggg aatgccgaag agccgtatct gcggccccca tcgcctgggg
     9121 cgcggtgccg tcttgacatg ccggggaggc gggagtaagg cttgatatgc ataggagttc
     9181 gggcaaccgt ccgacattac ggagtgggtg tgcatcctct cgccccgtat acgggatcaa
     9241 acggccgatg cacttctctt ggcagccgtg ttccgtgctc agttggcggg agcggtgcat
     9301 acactgccga ttcggcaaga agcgccaccc catagcgcgt gaacgcgccg gtgttgcgca
     9361 accaggtatg tccttcgttg caaacaccct gcggtggtca cggtcggcgc ttcgatgccc
     9421 aggccggtgt cccgccggcg aagggcgcgg cacagagtcg cctgacggtg gtgaattcca
     9481 cggccgaaat cagaaatgag aagacaggga gagcatcatg agcctccgca agatcgtccg
     9541 ggcctgggag gacccgaagt accgtgacag tctgagtgac cccgagctgg ccgacctgcc
     9601 ggacaacccg gcgggcgtca tagagctcac cgacgccgag ctggggcagg ttctgggtgg
     9661 cgcccagagc ggcaacagcg tcggctgcaa caccaagacc tgcgtctcga cccgcggcaa
     9721 ctcgcagaac ccctgccgga actgctgacg gcgaaatgcc tctttcggtc gcgcagcacc
     9781 tcatggatcg gcggctttcc ggttccagcg cggttgtacg cggccaccgt tgtacgtccg
     9841 gccgtattcg cggttctgca gcgtaacggc aacaggacac ccgcttgacg ccgaggtcag
     9901 gaatcaacga aacgagacga gggctgctag gcgctgtcca gcagccctcg tcgacgtgcc
     9961 gggctgagca gcgggtggaa ttcgagggga cggccaggac atgagagcgg aagaggtgtg
    10021 gcaggctccc gagtggtacc gggcattttc cctcctcgaa cgcggtgacc gcggtgaccg
    10081 cagcagtgac ggccgtgacc gcggtgatcg cggtgacaca ccgagtatcc gcccgacgga
    10141 gacgtcctac gcctcggacc tccttctcga gggagcgccg ggtcgcctga aagcctggaa
    10201 gagccagaag cctttcgagc ggcggccgtt gttcgctcag cggctggctc aggactcgct
    10261 ctcggaaagt gatctgctgg ctctgcttgc ggagcatccg gaaagtctga agacccgcgt
    10321 ccaggcaacc cccgactggc tgaccgttct ccggcaggca ttcacccatc cggattccgc
    10381 cgagagggcc gaggagtggg cgccgctgct cgagaaggcg gaggccgatc accccctcgc
    10441 cgccggcctg ttggcggtcg gcccgctcct gtggcacttt ttcgatcgtc tccaggaaag
    10501 gatccgtgga ctgcgcgaag aggtcgggtt cctcccgttc gacatgaaga agctccccgg
    10561 cgtgtacctc gcgaatctcg cgcccctcat cctcttccag ctcagcaaac cgatcctgct
    10621 cgagttgcat gtcgcccgcc tggaagggcg attggaaggc gggactgcgg aggaacgctt
    10681 cgaagacttc ttccggcgac tgcggcagga agggtcgatc gtggccgtgc tcgccaagta
    10741 ccccgtgctc gcacgccaac tggtgctcac gacggaacaa tgggccgact acctctacga
    10801 gttcttgacg cacttgtgcg cggactggca gtccgtccgc gcggccttcg ccccgggtgg
    10861 cgatcctgga ccgctggtcg acgtggaggc cggaaagggc gaccgtcatc ggaagggccg
    10921 cagtgtgctg ctgctgcggt tcggctcggg gatgaagctg ctgtacaagc cgagatcgct
    10981 gggtgtggac gtgcacttcc aggagttgct gtcctggttg gacgaccgag gggccgagcc
    11041 cgctctgcgg ccgctgaagc tggtcgactg cggcgaccac ggctggtcgg agttcgtcga
    11101 agcgaccccc tgcacgtgcg aggaagagat cgtccgtttc tatgagcgtc agggaagcta
    11161 cctggcgctg ttgtacgtcc tggacgccgc cgacctgcac aacgagaacc tgctcgccgc
    11221 gggcgagcat ccgatgctcg tggacctgga agccctgttc catcctcacg tccatgccga
    11281 gggaccggcc ctgggaaacc ttgcggtggg agcgctcgac cgctccgtgt ggcaggtcgg
    11341 gctgctgccg cggcgcgtgt ggtccgacca gaactccatc ggcgtggaca tgagcggcct
    11401 cggcgggcaa ccggggcaga cgaacccgca ccggcttgtc agctgggaaa gaccggggac
    11461 ggacgagatg cgggtgggcc ggcggcgtac cgagctgccc gtgagcgaga accggccccg
    11521 tctcggtgac caggacgtcg aggtctggaa gtatcaggac gccgtgctcg ccggcttcgc
    11581 cggaatgtac cgtctgatcc gcgagaaccg agcggcactg ctggcggaac agctcccgcg
    11641 cttcgcccat gacgagacac gcgtcgtcat ccgctcgacg aacgtctacg gcctgttgtg
    11701 gtacgagagc ttccacccgg atctgctgcg tgacgcgctc gaccgtgatc gcttcttcga
    11761 tcacctgtgg atcgaagcgg cgcagcgtcc ctgtctcgtt cccctcatcc cggcggagaa
    11821 gcgggacctg tggcacggtg acatcccgtt gttccacacc agcccaggca gccgggcggt
    11881 cctcaccgcg gaaggggagc gctgggaaga cttcctcgac gcgcccagcc tcgatctggt
    11941 gcggcaacga gtggagcggc tcggtgacga cgacctggcc aagcagagct ggatcatcaa
    12001 ggcgtcgctg gccacgctgc tcatggaccc tgaggacagg atcaaccggc cggcacaggt
    12061 tccctcgacg caccggcctt ccccggtcac cgggcgggtg ccgcgagaac agctgctggc
    12121 actggcgagc tccgtcgggc gccgactcga cgagctgtcc ttgcagaacg agcgcggcgc
    12181 gtactggctc ggcgtgggcc ctctggacga atccgcctgg ggcctcttcc cctcgggcag
    12241 cgacctctat tccgggacca gcggaatcgc gctcttcctc ggctacctgg gagcgatcac
    12301 cgacgagccc tcggccacgc tcctcgcacg ccgggcactg acatcggcgc gaacccaggt
    12361 gcgggagtgg ctccgggagg agccggatcc gggcggatcg gccccgacgg tcggcgcgtt
    12421 cgacggactg gcctccgtcg tgtacgtcct cacgagcctg ggcgtcctgt gggccgagca
    12481 ggatctcctc gacgaagcgg ccgaactggc cgagcgactg ccaccgctca tctccgggga
    12541 cctctcgctg gatgtcatct acggttcggc cgggtgcgcc ctctcgctgc tcagcctgca
    12601 cgcggtccgt ccctcgccac ggaccttgga cgtggcggtc cgctgcggcg agcggctcct
    12661 ggccagggcg cggcccgtgc accgcgggac cgcctggacg acgctcgagg atcaaccgcc
    12721 gctgggcggg ttctcgcacg gcacggccgg tatcgcgttg agccttctgc ggctggccgc
    12781 ccggagcggc gaggaccgat ttcggcgaac cgctctcagc gcgctccgct acgaccgcag
    12841 tctcttcgtt cccgagctga acaactgggc cgacctgcgc gtcttcgagc cccggaccgg
    12901 ccgggccgat cccgtcgagt cggccgtcga gccaccccgc aagagcatgg tggcctggtg
    12961 ccacggcgcc ccgggcatcg gcctggcacg tctcgccgcc ctcgaccagc tggccgacgc
    13021 gacgacacga gacgagatcg acgtcgccct gaccgccacg gaacagtacg gcttcgccat
    13081 gggccactcg ctctgccacg gcgcgctggg gaacctcgaa cttctcctga cggcggcgcg
    13141 gtcgctcgac agacccgcgg atcacgacgc gttggaacga gcgacggcgc tggtcgtggc
    13201 gagcatgcga accgacggct tcgtgacggg agtgcccctc ggagtggaga cgcccgggct
    13261 catgaccgga ctggcgggga tcgggtacga gctgctccgg ctggccgagc ccgacaaggt
    13321 cccgtccgtc ctcctcctgg ctccgccgcg gtggcaggcg ccgggctgag agaagggatc
    13381 cttggtcgtg ccccaccgtg tgatcttccg gcagagcgcc gtccaggcgt accggcgagg
    13441 tacggcgaag gacatcgtgc cccgcctcac cttccggccg gtcatcgtct gcctctggct
    13501 gttgctggcc gtgctgatcg ccgccgcggc actggcctgg acggtacggg tgccggccta
    13561 cgtcagcgcc cagggcacga tcctcccgaa cgacgcccgg gccggacccg gcggcggaac
    13621 gacacaagcc gccctgttcc tgccggcaga ccgatcggcg gacgtgcgcg tcggccggcc
    13681 ggtccacgcc cagatcggct cttcgggtcc gtccgtctcg ggttccgtcg tcagggtcga
    13741 gccgggcgtg atcggcccgg acaccgcgcg agccgtgtac cgcttcgagc ccggggccgg
    13801 taccgtccgg cagccctgga ccgtcgtgat cgtgcggctc ggaccgtcgc tgcgaccgtc
    13861 cgcctacgac gggagcctcc tgaccgctcg ggtggaggcc gggtcgcagc ggctcctgac
    13921 gctcttcccc ggctggggcg agtccgtcgg cggtgccgcg tgaagaaccc gttcgcacgg
    13981 ttccccggcc gccgaccgca ccggcgagcg gcaccgggcg cggcgccggg ggaatcggaa
    14041 cagcccaccc gtcgcacacc gtcccggcct ttccgcaccg tgaccgggag gacccgcaag
    14101 gcgcaccgcg ggacgcaccg caggagggtt cccgaggtca gacagatgag cgaggtggaa
    14161 tgcggcctcg cctgcctgac gatgatgctc aactaccacg gctgcgggac ctccttgtcg
    14221 gagatgcgca cgcgctgcgg cgtcggccgc gacggcctct ccgcgctgga gatcgtcagg
    14281 atcgcgcgcg accacggaat gcgggtgagg acggtctcgc tgccgcggaa cgacctccgc
    14341 ttcgtggcgc tccccgcgat cgtccactgg gagttcaccc acttcctcgt cgtcgaacgg
    14401 tggtcgcgcg accacgtcga cgtggtggac cccgccagag gccgctgtcg gctgacggcg
    14461 gacgagttcg acgccgggtt cacgggggtg gtcatcctcc tcgagccggg cgcggcattc
    14521 gaccgtcgcg cggccgcccc accccgcgcg accttccggg tgtacatcct tcagttcctg
    14581 cggcaggcgc ccgggacttc tctgcaactg ctcggggtct ccctgctgct gatcctgctc
    14641 gggcttgtcc tgccgatcct gaccggggtg gtggtggacc aggtcctccc cttccggctg
    14701 gacgacgtca tgccggtcct ggggatcggc atcgtcgcga tcttcgtcgc ccagaccgtc
    14761 gcgacgctgc tgcgggaatg gctgttggtg ttcctccgcg cgcgtatcga cgtcagcatg
    14821 atgctcggct tcgtcgagca ccttttcgaa ctgccctaca aatactttca gcagcggtcg
    14881 accggtgacc tgcttgcccg ggcggccagc aacgccatgc tccgcgaact gctgagcaac
    14941 cagctcctgt ccgccgtcat ggacagcgga ctggtgacgc tctatctgct cctcctcttc
    15001 tggcagtccc ccccgttcgg cgcgctcacg ctgggcgtcg gcctggtggg ggcgctggtc
    15061 ctcatgctca gccaaggcac catcagcagg ttgtcgggcc gggaactggc cgccttcgga
    15121 aagtcccagg gatatctggg cgaggcgatc gtcggcatcg gaacactgaa agcggccgga
    15181 gccgaaacac aggccttcga ccgctggtcg aacctgttct tcgaccacct caacatctcg
    15241 ctgcgccaca gctatgtgtc cggcaccgtg gcctcgatac tcggctccct gcccttgttc
    15301 ggacagctcg ggttgctgtg ggtgggtgcc acacaggtcc tcgacggatc gatcagcgtg
    15361 ggcaccatgg tggctctcct ggccctggcc gccgccttct tcgcgccgct cacgtcgctc
    15421 gtggccagcg cccagcagtt ccagctcgtc agcgccaacc tcgatcgcat acgtgacgtg
    15481 accgaggccg agccggagca ggtgcgacaa gtgtcacgac cggtcccacg gctcacgggg
    15541 cacctgcgga tggacagggt cggtttccgc tattcgcaga cggggcccca ggtactgcgt
    15601 gacatcgaca tgaccgcacg gcccggagag aggatcgcga tcgtcgggct ctccggctca
    15661 ggcaagagca cgctggggaa actgctgctc gggctctacg tccccacaca gggggacatc
    15721 ctgtacgacg gcctctcgct gcgggacgtc acgtggcagg agctgagacg ccagttcggc
    15781 gtcgtcctgc aggagagcgc actgttcagc gggtcgatcc tgtccaacat cgcgctcagc
    15841 aacccgtcga tcaagcgcga gcgagtggtc gcggctgccg agctggccgc catacacgac
    15901 gacatcatgg ccatgccgat gcagtacgac accttcgtct ccgagggcgg gagcgccctg
    15961 tccggcggtc agcgacagcg gctggccatc gcacgagcca tcgcgcacaa accggcgatc
    16021 atcatgctcg acgaggccac gagccatctg gacgtcgaga ccgagcggag agtcgcggag
    16081 aacctccgca ccctggcctg cacccagatc atcatcgcgc atcgcctgag cacgatccgc
    16141 gacgccgacc tgatcctggt gctcgaccag ggaaccatcg tggagcgggg cagccatcac
    16201 gacctgctac ggcgagccgg tcactacgcg agactcgtcg gccagcagct cgagtcgagc
    16261 gacgaggcac ggcccctccc cggcgccccc gaccgctgag aatccgaggc ccttcccgcc
    16321 gcgctccgaa gcgcggccgt atccgccaac cgccggccgg gttcatttct tgcgacgcct
    16381 gcccgcccgc ttcttcagtt cggcctggcc tcgtttcgtc cactcacctt gatggaggtg
    16441 gcagcgcgcc gtgcccttca tggtcttgtt ctgacagcgc cgtccggccg ccgtcggcca
    16501 accgcatttc ccttgcctcc actcggccac cgtcaacccc cgccgttccg cctcgcgttc
    16561 agggatccca gcctctgcca ccccgcagac acaggggcag ggcgcaaagt cggcgacctc
    16621 cgaccaccag ggcgcacgcg ggtcagtaca cccggcgcac tcaccggcct tcacgctcca
    16681 accgtgacgg tgccggcccg gtaaccgagc gcggggccgt caccgcgggg gctgaagtcg
    16741 agggacccgg gcggcgattt agggctgtcc cgtaaatgat ccctggtgcg ctgagtgagc
    16801 tgctgaggca gccacccgcg gggaacccgg ttgacgtccc gagcggtcac cgccggaaat
    16861 gcggagctca ggcgaccgat actcggaagg gatccgtggg gatgatctgt gcctcgtcga
    16921 agagctgttc caacgcctcg tgtccgtgtt gccgacggaa ttcgatctcg gcggcggtca
    16981 ccggcagggt ccacagaatg cggacgtgtc ctccaggcag cgggcagtgt tcaaggtcgg
    17041 ggccgtggag gtagggcaga ctgatcagca ggtggtcgca ggtcgacccc ggcacccacg
    17101 gttcaccgat cggcatgctg tgctccaggt cgagtgggtg ccctccgcag tggtagtagg
    17161 caatcatcgc catgagctcg atgaaccgct ggtcgcggac gtgtgcggtc atgacgaact
    17221 caaggccgtt accgtgcttc tccatcgggg cccagcaacc ggcggtcaca taggcccagc
    17281 tgtcgctgcg agggccgggc tccacgacga gaactcgcag agcgggcagt gccgctcgcc
    17341 gttcagggcc gaggtcgtag tcgacggcct cgacggaatg ccctacgaag aacgcccgga
    17401 cgtgtgactc aacggcctcc gcggccggca gccttgcatc actcaccgct cgatcatccc
    17461 aaactgcgat cgactacccc tgaccactta cacaacacca gtagggagac gagcccggcg
    17521 acgggccctg atccacacgc ccctcacgca cacctgcggc atgatggccc ctggactacg
    17581 gtccgggggt cgcgtcattt cctggggttg acctgctgat tcctggtcgg cggccagtcc
    17641 acgcacagtc ccaagccccc gacatacggc cgctccgagc ggcacacgcc tgcacatacg
    17701 ccaagacccc gtcctcagcg aaagcgctgg tggcggggcc tttgggcacc tcatgcaagg
    17761 cgcccccggc aggattcgaa cctgcgcaca cggctccgga ggccgttgag aatcactacg
    17821 tcattgcagg tcaggccttt tcactggctt gccgaggcga agttcgtcca cagctagtcc
    17881 acagagaacg ttcgccggat cgacccgtcc gtcttctcgc tggctccacc ccgacatgag
    17941 cgcgcccgtc ctgccctggc ggcctgaggc cgtcggtgcc ctcgccgtcc ggggaccggc
    18001 gaccagccac tgccagtcct ggggccccga gtcctggcgc ggcgtgcggg ccgcccgcta
    18061 cgagatccag gttgactgag agaccgccac ccgtgcgagc gcgattctct tcgttatgcc
    18121 gcaagccgtg agccgttccg tgatccggtg gggtgctacg ggggcgcaca aggggcgcac
    18181 tctctcggtg gtgtgcccca ctggtctcag ctgattcggc aaaactgctt ccgcttcctg
    18241 aggggttcct gaagcctgga acagggcacg agacacgggg atttgtgaag atcgattcat
    18301 gtgccaccaa ggtgtgccgc taggcagcgg tcgccgttga gggcggccag ttggttcggt
    18361 cgaggcgact cccggcacga ggcattttgc ctgtcaggca aacttcctga tggtgtgaca
    18421 cctctgtcgc ggccccccgt gtgctgcacg tagattgcga atcgataaca ggggttccct
    18481 gacgtggcgt tttattgaac gcttaagctc catgaatgag ggggacttgt gaaggttggt
    18541 gtgcgcgcct ggcggggggt caggcggggg gctggggcgc ttcattgatc ctgcagtcac
    18601 acacgaggag acccggctgc gcgccgctgg ggctggcagg accactcccg cagcgcggtc
    18661 catacagggt cgatgtcgaa ggcttccgct tccagggaag tcggccttgc ctcaatggct
    18721 tggggtatga gtccaccctg aacatcggct cgttggagca tggatacgtt cggctgatcc
    18781 cggaaatgga tgcgcgacgt catcctctaa gcccgatcgc tgacatcggg acgcgctggt
    18841 tgcagagagg gttagggccc taactcccga cccgcaggca gttggacgtt cggacgccgg
    18901 atgaccacgg ctcgtccgcc aaggccacca aaatcggcct gtcggtggct gttcctattg
    18961 tccgcagcag gcccgacggc gtgcgatgga acgcattacc ggaaacaggg gccatcttta
    19021 gttcaggagc cacgtaaatg cagggctgtc agtggtgcat cgtggtgaca gcagttgagg
    19081 cggtgtagtc gtgatgaaca aacgtgctga gtgggtcccc gacgccgggt tggtccgcga
    19141 ggttgatgac ctcttcgggc gggcgattga ttcgtatcgt gcgaatccga acctgatcac
    19201 ggagcacgcc aaccaagagg agtccatccg ggtcggcggt tactcgaatc gcacccttct
    19261 ggaactggtg cagaacgcgg ctgacgccat gtcgggggct gccgagcacg aggagggagc
    19321 ggggcgggtc gagatcgtcc tcgatcttga ccgccagacc ctgtactgcg cgaacgccgg
    19381 ccgtccgttc tcccgaagcg gcctcaccac gctggcccat gcccatctca gtggtaagcg
    19441 aggtgacgag atcgggcggt tcgggctcgg cttcaagtcg gtgctcgcgg tcaccgatac
    19501 cccacaggtg ttcagccggt cggtcgcctt cgagttccac tcgtcaaaga cgaaggcggc
    19561 gatcgcgacg atcgcgcccg cctccaagag acttccggtc ctgaggaccc tcacccggat
    19621 cgacgcggag gccgagttcg tcaaggatcc gatcctggcc gagctggcgg agtgggcggt
    19681 gacgatcgtc agattgccgc atgcgacgag gctggagaat ctcaagaagg agatcgagga
    19741 atttcggtcc gagttcctcc tcttcgtcaa ctcggtacgt gagatccggc tccgggtgat
    19801 cggggccgac gcgaacttcg tgacgagtca tgtgtcgcgg gagctgggcg acggcaggtt
    19861 tcgaatcgag cgtccggacg atgaccacga agagtggtac gtcgacaacc gaatgcatgt
    19921 acccagtccc gaggctcgga tcgaagtcgg cgaagcggtg tcacgtgacc gaatgaaggt
    19981 cacggttgcg atgccggcgc gcttcgcaca gcggagaacg ggcgagttct ggtcgtattt
    20041 cccgctccag gacaggacat cggcgtccgc acttttcaac gccccctgga gcgtcaacga
    20101 cgaccgcacc accctgcttt cgaacacgta caaccgagag atcctcgtga ctctctcggg
    20161 aatgttcctc gacatgctgc cgaaggtctc gtccgtcgac gatccggcag cacacctgga
    20221 ctacatgccg gcgcgtggcc gtgagaccca ctcgttcggc gacgagattc tctgcgccca
    20281 tgttccgcag ctcggctgtg agaaggctct gatccccgac gcgaccggca tgctacgcac
    20341 gccgccggag ctccgccccc tcgacttcgg cgtcagtgag gcgtccgaac gtgaccacga
    20401 agagtggatc aagtcgcccc acaccgacga cgccgtgccg cactggcgtt gttatgccaa
    20461 cggtcagcag cgtgtgactc gcttgagggc gctctacgtg tgcagcgtct ccaccgcatt
    20521 cgccgactca cgacccagag atgatctgaa ggcgttggag aggatcccca agcgaggtgt
    20581 cctgtcctgg ctgcgtgagt gggcggaggg gcccgacgtg gcctctgcag cgaaggcgct
    20641 cgatttcgtg ctgcgcaatc ccaacggctt cggtcctgcg aaggtcatac cgacgaccgg
    20701 tggcatgttg tccctcaagg accgcgaccg ggtcttcctc catcgtgcgg aggatgtcga
    20761 catcgaagga gcgtgcttcg tcgatccgga cttcctggcc gttcccggcg ttgaaaagaa
    20821 gctcggggac agaggcttcc gggacctcga tcctctctcg atgttcgagg ccaggatggc
    20881 caggctgtca ccggaggccg aggacgacga gctcccgaag ttctgggacg ctgccaccga
    20941 tgtgcccatg gcgcaggcac aaaaggtcgt ggcgggcaac aaggcgggcg ccctcaaggt
    21001 gccgacacgc gacggtggtt gggctccacc cacgtacgtg ctggatatcg acggccttgg
    21061 cgacagcgct cccgatcgag ttttggaccg gacgaagtgt gttccccagc tcgcacacgc
    21121 ggcaggcgtc atcaccgagc cggtggcctc gtactcgctc gaggacgagg tccacttcga
    21181 ggactactgc cagtacgtac tggacgaggt gaaccgtcgg ctcgggcccg gagagcgccc
    21241 tgtcgagcag gtcgagttcg acaggggaga gggtcccggt ccgttctcgg cgctcctgat
    21301 gttgcaagag gcgggcgcgc ccgaacccct gcgcgaacga tggacggaag gactgctcag
    21361 actcgaccag gtggggcact ggctctgtac tgacatcgac acggggctca gccatcgggt
    21421 cctgtcccct gtccgctggg cggcgggtcg ggccggcctg ctgaagtcga atcgcggcca
    21481 ccgggctccc ggtcgcgtcg tctccgcgtc tctcgttgag tacgaggccc tgctacctct
    21541 cttccgagga ccgcgccacg tcgaggacgc cctgaagctg ccgaaggacc tgggcgaggt
    21601 ccctgcggag gtcctgcgtg aagcgctcga ggcggaggtc acctcgccga tcagcaacgt
    21661 ggccctgacg ggattcgtcc tcaccgcgag tcggtgcgca ttcccggagg ggcatcccat
    21721 gttcatcccc gcccgggtgg gacgcgtcat cgagaggagg cggcccgatg cggtgtattt
    21781 ggcgacgacc gaggaggaac gcgagttcct cagcctgagg cagaagccgt acctcaaggt
    21841 ggatgaggac gaagcggacg agttcgtcga agtggtcgga tgccgacggt tcgaggacag
    21901 cttctccttc tcactcttgg tcgacggccg gcaggtcgag gagcgcgtca tcgacctgta
    21961 caccggactg cgttcgacgt tcgtcgagga caaggtcacg aacgcgaccg tggcgaaggt
    22021 cgtccagatc acgaagcgtg tgaccacgga ggacggtgtc gaggaccagt cgctcgagtg
    22081 gcaccgccag ggaatgaccc tggtggtcca ggcagaactc gacgaacgtc gtgtcctgca
    22141 catcgtcagc gaagcattcg acctgcgcct gtcgaatgtc gagttgagcg acatccttca
    22201 ggcacgcgtc gaccaacacc tggagacgca acggcaggac gcccgggccg cgtccagtga
    22261 cgtggagcgg ctggcgatct acatcggtga cgacacgctg aaggagaacc tgccgaaggg
    22321 actttggcag gcacttgagg gccaaggcct ggtggacggc tccacgtctg tcgccgagct
    22381 cttcctgacc gtctatggca gcgactcgat caagcttctc gcggaggagt tcagcgccga
    22441 ggggtacacg gacgttccca cgacgtgggc ggggggaacg tcgaccgtcg cctggctgcg
    22501 gaagatgggg ttcggcgcca agtacgccgg gcgtcgcacc cgacatcagg acgatgagtt
    22561 cgtcgtgccc ggtgccgtga agctcaagcc cctgcacgac ttccaggaga ggatcaggga
    22621 ggagctggag gaggtcctga cgtcccgggg acgggacggt cgtgcgctca agggcatggt
    22681 ggaactcccg acgggagccg ggaagacccg ggtggccacc gaaacggtgc tgcggctgtt
    22741 cgtcgacggc gagatgagcg gaaccgtgct ctggatcgcg cagtcggagg agctctgcga
    22801 gcaggcggtg cagacgttcg gtaccgtctg gcgttggctc ggggacgagc gtccgttgac
    22861 gatcggccgg ctctggaaca ccaacgtcgt ccacgaaccc gacaccgagt tcagtgtggt
    22921 cgtagccacc gacgccaagc tcgaccgggt ggccgacact cctgagtacg agtggctgag
    22981 cagggcctcc gcggtgttca tcgacgaggc gcaccgggcc ggcgggtcga agatgtacac
    23041 gaagatcctc aggtggctcg gagtcgacgg tcgtagctgg gaacggcctc tggtgggtgt
    23101 ctcggcgaca cccttcaagg ggagaagcga cgtcgtcacc aagccgacgg aggagctggc
    23161 ggcccgcttc ggtcaccaca tcatgagcgc cttcgacggt aacgcctacg aggagctgtc
    23221 gaagagggga gtcctcgccc gggtccgaca cgaggtgttg ccgggcgtgg acgtcgcact
    23281 gaagccagat gaactcgagc aggtccagtc gtggcgcaag ttggagccca aggtcctcga
    23341 ccgcatcggc cgcgaccagg cccgcatga
//
