LOCUS NZ_LMEQ01000004 18837 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_12, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000004 VERSION NZ_LMEQ01000004.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 241947) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 241947) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 223110 Orig. end :: 241947 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000004.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..18837 /candidate_cluster_numbers="1" /contig_edge="True" /product="terpene" /region_number="2" /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /tool="antismash" cand_cluster 1..18837 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" protocluster 1..18837 /aStool="rule-based-clusters" /category="terpene" /contig_edge="True" /core_location="[10000:16698](+)" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..16698 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" gene complement(157..750) /gene="idi" /locus_tag="ASD48_RS13530" /old_locus_tag="ASD48_35490" CDS complement(157..750) /EC_number="5.3.3.2" /GO_function="GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IEA]" /GO_process="GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="idi" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020129457.1" /locus_tag="ASD48_RS13530" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35490" /product="isopentenyl-diphosphate Delta-isomerase" /protein_id="WP_057601811.1" /transl_table=11 /translation="MPITPATATQTSPNGTADAILLELVDENGVTIGTAEKLAAHQPPG QLHRAFSVFLFDERGRLLLQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEEL GVSPSLLAEAGTVRYNHPDPESGLVEQEYNHLFVGLVQSPLRPDAEEVGDTAFVTPAEL AERHAADVFSSWFMTVLDAARPAVRELTGPSAGW" misc_feature complement(895..908) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 18.43" /tool="antismash" gene complement(938..1879) /locus_tag="ASD48_RS13535" /old_locus_tag="ASD48_35495" CDS complement(938..1879) /GO_function="GO:0008324 - monoatomic cation transmembrane transporter activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009339288.1" /locus_tag="ASD48_RS13535" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35495" /product="cation diffusion facilitator family transporter" /protein_id="WP_057601812.1" /transl_table=11 /translation="MGAGHDHGHTHTHVPATATAAAAYRGRLRVALSITLAVMVVEIVG GVLADSLALIADAAHMATDALGLGMALLAIQFANRPPSANRTFGLARAEILAALANCLL LLGVGGYVLFEAVQRFFTPATTEGGLMIWFGAFGLVANVISMSLLMRGQAESLNVRGAF LEVAADALGSVAVLISAVVILTTGWQTADPIASLVIGLMIVPRTVKLLRETLDVLLESA PKDVDMAEVRSHILALDGVEDVHDLHAWTITSGMPVLSAHVVVRSDALNAIGHEKMLHE LQGCLGHHFDVEHCTFQLEPSGHAEHEARLCH" misc_feature 1973..1987 /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 18.72" /tool="antismash" misc_feature complement(2002..2016) /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 17.35" /tool="antismash" misc_feature 2178..2192 /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 19.89" /tool="antismash" misc_feature complement(2312..2326) /note="TFBS match to MexT, Global virulence regulator, confidence: weak, score: 16.81" /tool="antismash" gene 2547..4394 /locus_tag="ASD48_RS13540" /old_locus_tag="ASD48_35500" CDS 2547..4394 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003996269.1" /locus_tag="ASD48_RS13540" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35500" /product="DUF5941 domain-containing protein" /protein_id="WP_057601813.1" /transl_table=11 /translation="MSTAILTGSPVPGSSIEGDLRSLGFDVRTASDAGDAEALLAAVPG DQRVAVVDARFVGHEHALRLGLTDPRFPLGAIPGAVTAQPAGRQALTRAMARENSANAG TAPGGAPALPKSSVGHVDSVDSLADRVVAALDADGVDVHRPELGSLVAEVPADPQARNE ARQAVAAVDDEAIRLKSAVKARDGFFTTYCISPYSRYVARWCARRGLTPNQVTTASLIT ALIAAACAATGTRGGFVAAGVLLIASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKE YAYYAGLALGAARGGDDVWALALGAMVLQTCRHVVDFSFNEANHDATANTSPTAALSDK LDSVGWTVWVRRMIVLPIGERWAMIAVLTAATTPRITFYALLVGCAFAATYTTAGRVLR SLTRKARRTDRAAQALADLADSGPLTGLLTRTLPVGIRIPAPLSAAAGVLLLVLAASLD GPGFSVLLAAVLYVLLSADALVRPLKGALDWLVPPLFRAGEYCTVLVLAAKADVDGALP AAFGLVAAVAYHHYDTVYRIRGNAGAPPAWLVRAIGGQDGRTLLVVVLAVLLTASQFTV ALTALAVVVALVVLLESIRFWVAAHRAGAPSVHDEGEPA" gene 4391..5143 /locus_tag="ASD48_RS13545" /old_locus_tag="ASD48_35505" CDS 4391..5143 /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) NTP_transf_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010983099.1" /locus_tag="ASD48_RS13545" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35505" /product="phosphocholine cytidylyltransferase family protein" /protein_id="WP_054241363.1" /sec_met_domain="NTP_transf_3 (E-value: 1.1e-11, bitscore: 39.0, seeds: 297, tool: rule-based-clusters)" /transl_table=11 /translation="MIGLVLAAGAGRRLRPYTDSLPKALVPVGPAGIEGEPTVLDLTLG NFAEIGLTEVAVIVGYRKEAVYERKAALEAKYGLKLTLIDNDKAEEWNNAYSLWCGRDA LKDGVILANGDTVHPVSVEHTLLAARGEGRQIILALDTVKSLADEEMKVVVDPDLGVQR ITKLMDPADATGEYIGVTLIEGDAAPALAEALKTVWESDPQQFYEHGYQELVDGGFRID VAPIGDVAWVEIDNHDDLARGREIACQY" gene 5131..6192 /locus_tag="ASD48_RS13550" /old_locus_tag="ASD48_35510" CDS 5131..6192 /GO_function="GO:0030554 - adenyl nucleotide binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Fe-ADH" /gene_functions="biosynthetic-additional (rule-based-clusters) DHQ_synthase" /gene_functions="biosynthetic-additional (smcogs) SMCOG1181: dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007494151.1" /locus_tag="ASD48_RS13550" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35510" /product="iron-containing alcohol dehydrogenase family protein" /protein_id="WP_057601814.1" /sec_met_domain="Fe-ADH (E-value: 5.6e-23, bitscore: 75.0, seeds: 218, tool: rule-based-clusters)" /sec_met_domain="DHQ_synthase (E-value: 6.3e-10, bitscore: 32.3, seeds: 76, tool: rule-based-clusters)" /transl_table=11 /translation="MPVLTRLIPSPVVVDIRPGALDDLVGVLADERISHSGKLAIAVSG GSGARLRERLTPALPGATWYEVGGGTLDDAVQLATDIKAGHFDAVVGLGGGKIIDCAKF AAARVGLPLVAVPTNLAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPVRY VRAGIGDAVSNISAIADWELANRIKGEKIDGLAAAIARQAGEAVLRHPGGIGDTGFLQV LAEALVLSGVAMSVSGDSRPSSGACHEINHAFDLLFPKRAAAHGEQCGLGATFAMFLRG AHEESAYMAQVLRRHGLPVLPQEIGFTVDEFVRAVEFAPETRPGRYTILEHLDLKTEQI KDIYADYVKAIGS" gene 6170..6949 /locus_tag="ASD48_RS13555" /old_locus_tag="ASD48_35515" CDS 6170..6949 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014049651.1" /locus_tag="ASD48_RS13555" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35515" /product="CDP-alcohol phosphatidyltransferase family protein" /protein_id="WP_079073746.1" /transl_table=11 /translation="MSRPSVAELRPVVHPPGVKDRRSGEHWMGRLYMREVSLRVDRYLV NTRVTPNQLTYLMTVFGVLAAPALLVPGITGAVLGVVCVQMYLLLDCVDGEIARWKKQY SLGGVYLDRVGAYLTDAAVLVGFGLRAADPWGTGRIDWLWAFLGTLAALGAILIKAETD LVGVARHQGGLPPVKESASEPRSSGMALARRAASALQFHRLILGIEASLLILVLAVVDQ LRGDLFFTRLGVAVLAGIALLQTLLHLVSILASSRLK" gene 6946..7830 /locus_tag="ASD48_RS13560" /old_locus_tag="ASD48_35520" CDS 6946..7830 /EC_number="2.4.-.-" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Glycos_transf_2" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010983096.1" /locus_tag="ASD48_RS13560" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35520" /product="glycosyltransferase" /protein_id="WP_057601815.1" /sec_met_domain="Glycos_transf_2 (E-value: 8.2e-15, bitscore: 48.8, seeds: 256, tool: rule-based-clusters)" /transl_table=11 /translation="MSAPGKVGAVVITMGNRPDELRALLDSIAKQDGDRVEVVVVGNGS PVPDVPEGVRTIELPENLGIPGGRNVGIEAFGPSGRDVDVLLFLDDDGLLAHHDTAELC RRAFADDPRLGIVSFRIADPDTGVTQRRHVPRLRAADPMRSSRVTTFLGGANAVRTKVF AEVGGLPDEFFYAHEETDLAWRALDAGWMIDYRSDMVLYHPTTAPSRHAVYHRMVARNR VWLARRNLPAPLVPVYLGVWLLLTLVRRPSGSALKAWFGGFREGWSTPCGPRRPMKWRT VWRLTRLGRPPVI" gene 7931..8860 /locus_tag="ASD48_RS13565" /old_locus_tag="ASD48_35525" CDS 7931..8860 /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003994380.1" /locus_tag="ASD48_RS13565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35525" /product="ABC transporter permease" /protein_id="WP_057601816.1" /transl_table=11 /translation="MSETTHDVGVVVTAPPSPDEGLTAAQLAAKYGLAVSGARPPLREY VRQLWGRRHFIMAFSRAKLASQYSQAKLGQLWQVATPLLNAAVYFMIFGLLLNAGRGMT KEVYIPFLVTGVFVFMFTQSSVMTGVRAISGNLGLVRALHFPRASLPISFALQQLQQLL YSMLVLFIVVIGFGSYPDASWALIVPILALQFCFNSGLALIFARAGAKTPDLAQLMPFV MRTWMYASGVMFSIPVFLADKPQWVANILQWNPAAIYMDLMRFALIEEYSAENLPAHVW AVAGGWAVLVALGGFVYFWQAEERYGRG" gene 8853..9641 /locus_tag="ASD48_RS13570" /old_locus_tag="ASD48_35530" CDS 8853..9641 /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0016887 - ATP hydrolysis activity [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020129465.1" /locus_tag="ASD48_RS13570" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35530" /product="ABC transporter ATP-binding protein" /protein_id="WP_057601817.1" /transl_table=11 /translation="MVEPLAGQRIPTVIADDVHIVYRVNGAKSGRGSATAALSRIVKRG SDESARGVRKVHAVRGVSFVAHRGEAIGLIGSNGSGKSTLLRAIAGLLPPESGKVYTDG QPSLLGVNAALMNDLTGERNVTLGGLAMGMSREQIKERYQEIVDFSGINEKGDFITLPM RTYSSGMQARLRFSIAAAKDHDVLMIDEALATGDAKFRRRSEARVRELREHAGTVFLVS HSNQSIRDTCDRVLWLERGELRLDGPTEEVLKEYEKFSGK" gene 10001..10903 /gene="hpnC" /locus_tag="ASD48_RS13575" /old_locus_tag="ASD48_35535" CDS 10001..10903 /EC_number="2.5.1.21" /GO_function="GO:0004311 - farnesyltranstransferase activity [Evidence IEA]" /codon_start=1 /gene="hpnC" /gene_functions="biosynthetic (rule-based-clusters) terpene: phytoene_synt" /gene_functions="biosynthetic (rule-based-clusters) terpene: PT_phytoene_like" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019985319.1" /locus_tag="ASD48_RS13575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35535" /product="squalene synthase HpnC" /protein_id="WP_057601818.1" /sec_met_domain="phytoene_synt (E-value: 2.7e-40, bitscore: 132.0, seeds: 8, tool: rule-based-clusters)" /sec_met_domain="PT_phytoene_like (E-value: 3.3e-42, bitscore: 138.4, seeds: 61, tool: rule-based-clusters)" /transl_table=11 /translation="MTAPAAPRIGDPERGTLDKAADENFPVAPFFLPRAWRDDLMAVYG FARLVDDIGDGDLAPGGADARLLGVSATAAEDRLALLDAFEADLRRVFDGTPRHPLLRR LQPTVRRRSLGPEPFLGLIAANRQDQLVTRYETYDDLLAYCELSANPVGRLVLAVTGAA TPERIRRSDAICTALQIVEHLQDVSEDLSRDRVYLPAADMKRFHVKESDLAMNTAGASV RALVAFEAQRARDLLNEGAPLVGSVHGRLRLLLAGFVAGGSAAIKAIAAAGYDVLPGPP KPGRLRLLREVGVTLRGEG" gene 10900..11850 /gene="hpnD" /locus_tag="ASD48_RS13580" /old_locus_tag="ASD48_35540" CDS 10900..11850 /EC_number="2.5.1.103" /GO_function="GO:0016767 - geranylgeranyl-diphosphate geranylgeranyltransferase activity [Evidence IEA]" /GO_process="GO:0016117 - carotenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="hpnD" /gene_functions="biosynthetic (rule-based-clusters) terpene: phytoene_synt" /gene_functions="biosynthetic (rule-based-clusters) terpene: PT_phytoene_like" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020129467.1" /locus_tag="ASD48_RS13580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35540" /product="presqualene diphosphate synthase HpnD" /protein_id="WP_057601819.1" /sec_met_domain="phytoene_synt (E-value: 6.6e-58, bitscore: 189.7, seeds: 8, tool: rule-based-clusters)" /sec_met_domain="PT_phytoene_like (E-value: 1.9e-69, bitscore: 227.9, seeds: 61, tool: rule-based-clusters)" /transl_table=11 /translation="MIRAVEPSPHVSAPVLAAYGYCETVTGQQARNFAYGIRLLPTPKR RAMSALYAFSRRVDDIGDGALDGEVKTARLEETRALLTRVRAGEVEEDDTDPVAVALAH TARVFPIPLRGLDELIDGVLMDVRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTERGA RGAERAPEYADTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCSTGFDGPKPPEG SDFVGLVHFEVRRARALFAEGYRLLPLLDRRSGACVAAMAGIYRRLLDRIERDPEAVLR GRVSLPGREKAFVAVRGLSGLDARHVSRRTVRRHP" gene 11999..13420 /gene="hpnE" /locus_tag="ASD48_RS13585" /old_locus_tag="ASD48_35545" CDS 11999..13420 /EC_number="1.17.8.1" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene="hpnE" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1222: dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020129468.1" /locus_tag="ASD48_RS13585" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35545" /product="hydroxysqualene dehydroxylase HpnE" /protein_id="WP_057601820.1" /sec_met_domain="DAO (E-value: 2.1e-10, bitscore: 34.4, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MNDEQLADAAEASGPSGRTAVVVGGGLAGVTAALALADAGVRVTL LEGRPRLGGLAFSFTRGELTVDNGQHVYLRCCTAYRWFLDRIEGSALAPLQDRLDVPVV DVAAPEGRRLGRLRRDALPVPLHLGRSLATYPHLSLAERARVGRAALALKGLDLADPRL DAQDFGSWLTAHGQSARAVEALWDLVGVATLNAVAGDSSLGLAAMVFKTGLLSDPGAAD IGWAHVPLGELHDRLARKALDSAGVRTEVRTRVTSLSSDDNGTWSVQVPGETLRADTVV LAVPQREAYDLLPAGALDHAERLLEIGTAPILNVHVVYDRKVLDKPFFAALGTPVQWVF DRTAASGLREGQYLALSQSAAHDEIDEPVAALRERYLPELERLLPRTRGAGVRDFFVTR ERTATFAPTPGVGRLRPGARTRTPGLYLAGAWTATGWPATMESAVRSGVSAADAALSAL GRPRPRRLFEFEEAA" gene 13531..14559 /locus_tag="ASD48_RS13590" /old_locus_tag="ASD48_35550" CDS 13531..14559 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene: PT_FPPS_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182: Polyprenyl synthetase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020129469.1" /locus_tag="ASD48_RS13590" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35550" /product="polyprenyl synthetase family protein" /protein_id="WP_057601821.1" /sec_met_domain="PT_FPPS_like (E-value: 1.8e-57, bitscore: 188.3, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MDVTALLERGRTLATPVLRAAVDRLAPPMDTVAAYHFGWIDAHGN PTDGDGGKAVRPALAVLSAEVAGAAPEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHR DTVWKVHGPAQAILVGDALFALAGEILLELGTAEAARATHRLTVATRALIDGQAQDISY EHRDRVSVEECLEMEGNKTGALLACASSIGAVLGGADRHTADALEKYGYHLGLAFQAVD DLLGIWGDPESTGKQTWSDLRQRKKSLPVVAALAAGGSASERLGEILAADAKSSDFETF SEGEFAARAALIEEAGGRDWTAGEARRQHAVALDALNAVDMSEQVRDRFTALADFVVVR KR" misc_feature 14643..14656 /note="TFBS match to ArgR, Regulator of arginine biosynthesis genes, confidence: weak, score: 17.64" /tool="antismash" gene 14677..16698 /gene="shc" /locus_tag="ASD48_RS13595" /old_locus_tag="ASD48_35555" CDS 14677..16698 /EC_number="5.4.99.17" /GO_function="GO:0051007 - squalene-hopene cyclase activity [Evidence IEA]" /GO_process="GO:0019746 - hopanoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene="shc" /gene_functions="biosynthetic (rule-based-clusters) terpene: T2TS" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016327863.1" /locus_tag="ASD48_RS13595" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35555" /product="squalene--hopene cyclase" /protein_id="WP_057601822.1" /sec_met_domain="T2TS (E-value: 1.6e-152, bitscore: 502.5, seeds: 58, tool: rule-based-clusters)" /transl_table=11 /translation="MTATTDGSTGALPPRAAAASETDIIIPVAAGVQEAATRAMQRATD FLLAGQDAEGWWKGDLETNVTMDAEDLLLRQFLGIRDEATTRAAALFVRGEQREDGTWA TFYGGPPDLSATVEAYVALRLAGDAPEAPHMRRASGWIREQGGIASARVFTRIWLALFG WWKWEDLPELPPELLFFPKWFPLSIYNFGCWARQTIVPLTVVSAKRPVRPAPFPLDELH TDPARPNPARPLAPVNSWDGLFQRLDKVVRGYRSVAVRRLRGAALNAAARWIIERQEND GAWGGIQPPAVYSVIALHLLGYDLRHPVMRAGLESLDRYAVWREDGARMIEACQSPVWD TCLATIALADAGLPADHPQLVKAADWMLGEQVVRPGDWSVSRPQLPPGGWAFEFHNDNY PDIDDTAEVVLALRRVKHHDPERMDRAIARGVRWNLGMQSKNGGWGAFDVDNTSPFPNR MPFCDFGEVIDPPSADVTAHVVEMLAVEGLSHDPRTRRGIEWLLAEQEPDGSWFGRWGV NYVYGTGSVVPALTAAGLPAQHPAIRRAVSWLERVQNDDGGWGEDLRSYQDATRWSGRG ASTASQTAWALMALLAAGERDSKAVERGVAWLAQTQREDGSWDEPYFTGTGFPWDFSIN YHLYRQVFPLTALGRYVHGEPFSKQPATHAASAEVKGS" gene 16698..17339 /locus_tag="ASD48_RS13600" /old_locus_tag="ASD48_35560" CDS 16698..17339 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016431357.1" /locus_tag="ASD48_RS13600" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35560" /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate reductase" /protein_id="WP_057601823.1" /transl_table=11 /translation="MSTQSVPSPLLIACALGIEHLALRMGERGGADGPVTVLRTGMGPK AAERSVTRLLADPLFAGAAVLATGFCAGLAPGMHPGDLVVAEETRDPRGSVPCVGTELL VKELARTLPGRTVHTGPLTGSDHVVRGHERADLLATGAIALDMESAATLLSAVRAEPRP VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFFEWHRNVLLPRR" gene 17345..18367 /gene="hpnH" /locus_tag="ASD48_RS13605" /old_locus_tag="ASD48_35565" CDS 17345..18367 /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /GO_function="GO:0051536 - iron-sulfur cluster binding [Evidence IEA]" /codon_start=1 /gene="hpnH" /gene_functions="biosynthetic-additional (rule-based-clusters) PF04055" /gene_functions="biosynthetic-additional (rule-based-clusters) QueE" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007386169.1" /locus_tag="ASD48_RS13605" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35565" /product="adenosyl-hopene transferase HpnH" /protein_id="WP_057601824.1" /sec_met_domain="PF04055 (E-value: 2.4e-18, bitscore: 60.8, seeds: 518, tool: rule-based-clusters)" /sec_met_domain="QueE (E-value: 5.7e-10, bitscore: 32.7, seeds: 32, tool: rule-based-clusters)" /transl_table=11 /translation="MAMPLRQSIKVATYLAEQKLRKREKFPLIVELEPLFACNLKCEGC GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF LCTNAMLLRKKLDKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVAAIKEAKQRGF RVTTNSTFFNTDTPQTIIEVLNYLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL FKKAFSGGNRRRWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVP TYRELIEETDWDKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRALRETVNGNRE " gene 18372..>18837 /locus_tag="ASD48_RS13610" /old_locus_tag="ASD48_35570" CDS 18372..>18837 /EC_number="1.17.7.3" /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin) [Evidence IEA]" /GO_process="GO:0016114 - terpenoid biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011031167.1" /locus_tag="ASD48_RS13610" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_35570" /product="flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase" /protein_id="WP_199875782.1" /transl_table=11 /translation="MTAVSLGVPGMPVRPVASRRESRRIQVGPVAVGGGAPVSVQSMTT TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQPKYV FAAIEAGCAAVRVNPGNIKQFDDKVREIAKAAKEHGTPIRIGVNAGSLDRR" ORIGIN 1 gaggccgacc acggtcgcac gggcggccgg ggactgctgc tggtgcggga gatcaccctg 61 gaggcgggcg gggtctgcga cgtcgagcac acgtcgggcg gcggcaaggt gatctgggcc 121 gccctgccgc tgaagcccgt gcgggtgccc tgagggtcac cagccggccg acggccccgt 181 cagctctctg accgccgggc gggcggcgtc caggacggtc atgaaccagg acgagaacac 241 gtccgcggca tgccgctccg ccagctcggc gggcgtcacg aaggccgtgt cgccgacctc 301 ctccgcgtcc ggccgcagcg gggactgcac cagccccacg aacaggtggt tgtactcctg 361 ctcgaccaga cccgactccg ggtccgggtg gttgtagcgg accgtgcccg cctcggcgag 421 cagcgacggg gagaccccga gctcctcgaa ggtgcgccgc gcggccgccg cgaacggtgc 481 ctcaccgggg taggggtgac cgcagcaggt gttggaccac accccggggg agtggtactt 541 gccgagcgcc cgctgctgga gcagcagccg gccccgctcg tcgaagagga acacggagaa 601 ggcgcggtgc agctgccccg gcggctgatg ggcggccagc ttctccgcgg tgccgatcgt 661 gacgccgttc tcgtcgacca gctccagcaa gatcgcgtcc gcggtgccgt tcggcgacgt 721 ctgtgtcgcg gtggcaggtg tgatcggcat acccatcctt agcatcggtc ctcgcgtccc 781 cagtctgccg tacgcgtccg gcactcccgg cacttcgcgc gaaagcgcgc atgtcccgca 841 cggcaagggg cccggtaggt gatcttgccc ggcgccggga tcggagaacc gtccggaacg 901 tgtgtgcgga tcatgcggcg cgggcgtcgg cgcgcgctca gtggcagagc cgggcctcgt 961 gttccgcgtg cccgctcggc tccagctgga aggtgcagtg ctccacgtcg aagtggtggc 1021 ccaggcagcc ctggagctcg tgcagcatct tctcgtggcc gatcgcgttc agcgcgtccg 1081 agcgcaccac cacgtgcgcc gacagcaccg gcatcccgga ggtgatggtc cacgcgtgca 1141 gatcgtggac gtcctccacc ccgtccaggg cgagtatgtg ggagcgcacc tccgccatgt 1201 cgacgtcctt gggggccgac tccagcagca cgtcgagcgt ctcgcgcagc agcttcacgg 1261 tgcgcggcac gatcatcagg ccgatgacga gcgaggcgat cgggtcggcg gtctgccagc 1321 cggtggtcag gatcaccacc gccgagatca gcaccgccac cgaccccagg gcgtccgccg 1381 ccacctccag gaacgccccg cgcacgttca ggctctcggc ctggccgcgc atcagcagcg 1441 acatcgagat cacgttcgcg accagaccga acgcgccgaa ccagatcatc agcccgccct 1501 cggtggtggc gggggtgaag aaccgctgga cggcctcgaa caggacgtag ccgcccaccc 1561 cgagcagcag cagacagttg gcgagggcgg ccaggatctc ggcgcgggcc agtccgaagg 1621 tgcggttggc gctcggcggc cggttggcga actggatggc cagcagcgcc atgcccagcc 1681 ccagcgcgtc cgtcgccatg tgcgcggcgt ccgcgatcag cgcgagggag tccgcgagca 1741 ccccgccgac gatctcgacg accatgacgg cgagcgtgat cgacagggcg acgcgcagtc 1801 tgccccggta cgccgccgcg gccgtcgcgg tggccggcac gtgggtgtgc gtatggccgt 1861 ggtcgtgccc agcccccatg gaagcagccc ttctgtggtc cgtcgtgggc cgtcgcgttc 1921 tgccccgcga tcacagtgaa ctacgggtgg ggggtatccg gcaacgcggc actgaacacc 1981 gttgtcatgt gccctgacct gcgaaaacga atcgcaggtc agcgcgtccc cgcctgctgc 2041 tcgccgtgga tgcggccgtc ggccccggca cggcgggagg ccgcccgggg ccgcgaagcg 2101 ctccgcggcc ttgtcgcgac cccggtcgcg gcacccgtgg gggacgcgtt ccgtacccct 2161 ggtgcccgga agtcaccggg atatccgttc cggcggtgat gaggcatgtc atgccggaag 2221 ttcccgtccc gaccggtacg ggcacaccgg gccggtggac aatgtcctgg atgtcggctc 2281 tcgggggcac ggtttgtcgc ccgggccgcc gatcaccgat gatgatctcg gcaaaggccg 2341 gttcaagccg agttcaagcc gtgccgccgg accacggcga tcgtgcctga acgggcggtg 2401 aacacggcgt tcccggcatc cgatagcctc tgccgacatg ccgcccgcct ggtgcggcca 2461 ccggtgaagc cgccggtgcg gcccaggggc gcctccatcg tgtacatgac cggcgtcaac 2521 gcgccggacc cagggagtga gttcggttgt cgaccgccat cctcaccggc tcgccggtcc 2581 ccggatcgtc gatcgagggc gatctgcggt ccctcggctt cgacgtccgg accgcctccg 2641 acgccggtga cgccgaggcc ctcctcgccg ccgtccccgg cgaccagcgc gtcgccgtcg 2701 tggacgcccg cttcgtgggt cacgagcacg cgctgcgtct cggcctcacc gacccccgtt 2761 tcccgctcgg cgcgatcccg ggggcggtga ccgcgcagcc ggccggccgg caggccctga 2821 cccgcgcgat ggccagggag aactcggcga acgccggcac cgcccccggg ggtgctcccg 2881 cgctgccgaa gtcgagcgtg ggacacgtcg acagcgtcga cagcctcgcc gaccgggtcg 2941 tcgccgccct cgacgccgac ggcgtcgacg tgcaccgccc cgaactgggc agcctggtcg 3001 cggaggtccc ggccgacccg caggcccgca acgaggcccg gcaggccgtc gccgccgtcg 3061 acgacgaggc gatccgcctg aagtcggccg tcaaggcgcg cgacggcttc ttcaccacct 3121 actgcatcag cccgtactcg cgctatgtcg cccgctggtg cgcccgccgc ggcctcaccc 3181 ccaaccaggt caccaccgcc tcgctgatca ccgcgctgat cgcggcggcc tgcgcggcca 3241 ccggcacccg gggcgggttc gtcgcggccg gcgtgctgct gatcgcgtcc ttcgtgctgg 3301 actgcaccga cggccagctc gcccgctact ccctgcagta ctccacgctc ggcgcctggc 3361 tcgacgccac cttcgaccgc gccaaggagt acgcctacta cgcgggtctc gcgctcggcg 3421 cggcccgcgg cggcgacgac gtgtgggccc tggcgctggg cgcgatggtc ctgcagacct 3481 gccggcacgt cgtggacttc tccttcaacg aggccaacca cgacgccacc gcgaacacca 3541 gccccaccgc cgccctctcc gacaagctcg acagcgtcgg ctggacggtc tgggtgcggc 3601 ggatgatagt cctgcccatc ggtgaacgat gggccatgat cgccgttctc accgctgcca 3661 ccaccccccg catcaccttc tacgcgctgc tcgtcggctg cgcgttcgcg gccacctaca 3721 ccacggcggg ccgggtcctg cgctcgctga cccgcaaggc ccggcggacc gaccgggcgg 3781 cgcaggcact ggcggacctc gccgacagcg gcccgctcac cggactgctg acccgcacgc 3841 tccccgtggg catccgcatc ccggccccgc tcagcgcggc cgccggcgtc ctcctgctgg 3901 tcctcgccgc ctcgctcgac gggccgggct tctcggtcct cctggccgcc gtcctgtacg 3961 tcctgctctc cgccgacgcc ctcgtgcgcc ccctcaaggg cgccctcgac tggctggtcc 4021 cgccgctctt ccgggccggg gagtactgca ccgtcctcgt cctcgcggcc aaggccgacg 4081 tggacggagc gcttcccgcg gctttcgggc tggtcgccgc cgtcgcctac catcactacg 4141 acacggtgta ccgcatccgc ggcaacgccg gagcgccgcc ggcctggctg gtgcgcgcca 4201 tcggggggca ggacgggcgc acgctgctcg tcgtcgtgct ggccgtgctg ctcacggcct 4261 cgcagttcac ggtcgcgctc acggccctcg ccgtggtcgt cgccctcgtg gtgctcctcg 4321 agagcatccg cttctgggtc gccgcccacc gggcaggcgc cccgtccgta cacgatgaag 4381 gagaacccgc atgatcggcc tcgtgctggc ggccggcgcc ggacggcgtc tgcgccccta 4441 caccgacagc ctgcccaagg cgctggtgcc ggtggggccc gcgggcatag agggcgagcc 4501 cacggtcctg gacctgacgc tcggcaactt cgccgagatc ggtctgaccg aggtcgcggt 4561 catcgtcggc taccgcaagg aggccgtgta cgagcgcaag gcggcgctgg aggcgaagta 4621 cggcctcaag ctcaccctca tcgacaacga caaggccgag gagtggaaca acgcctactc 4681 cctgtggtgc ggccgtgacg ccctcaagga cggcgtcatc ctcgccaacg gcgacaccgt 4741 ccacccggtg tccgtcgagc acacgctgct cgccgcccgc ggcgagggca ggcagatcat 4801 cctcgcgctc gacacggtga agtccctcgc cgacgaggag atgaaggtcg tcgtcgaccc 4861 cgacctgggc gttcagcgga tcaccaagct gatggacccg gccgacgcca ccggcgagta 4921 catcggcgtc accctcatcg agggcgacgc ggcccccgcc ctggccgagg cgctcaagac 4981 cgtgtgggag agcgacccgc agcagttcta cgagcacggc taccaggagc tcgtcgacgg 5041 cggcttccgc atcgacgtgg ccccgatcgg cgatgtcgcg tgggtcgaga tcgacaacca 5101 cgacgatctc gcccgtggac gggagatcgc gtgccagtac tgacccggct gatcccctca 5161 ccggtcgtcg tggacatccg cccgggtgcc ctcgacgacc tggtcggggt tctcgccgac 5221 gagcgcatct cgcactcggg caagctcgcg atcgccgtca gcggcggctc gggcgcccgg 5281 ctgcgcgagc gcctcacccc cgccctgccc ggcgccacct ggtacgaggt cggcggcgga 5341 accctcgacg acgccgtcca gctggccacc gacataaagg ccggccactt cgacgcggtc 5401 gtcggcctgg gcggcggcaa gatcatcgac tgtgccaagt tcgccgccgc ccgcgtgggc 5461 ctcccgctgg tcgccgtgcc gacgaacctc gcgcacgacg gtctgtgctc gccggtcgcc 5521 accctcgaca acgacgcggg gcgcggctcc tacggtgtgc cgaacccgat cgccgtcgtg 5581 atcgacctgg acgtcatccg cgaggccccg gtccgctatg tgcgggccgg catcggtgac 5641 gccgtctcca acatctccgc catcgcggac tgggagctcg ccaaccggat caagggcgag 5701 aagatcgacg gcctggccgc cgcgatcgcc cgccaggcgg gcgaggcggt gctgcgccac 5761 ccgggcggca tcggggacac cggcttcctc caggtactgg ccgaggcgct ggtgctcagc 5821 ggcgtcgcga tgtcggtgtc gggcgactcc cgcccgtcct ccggcgcctg ccacgagatc 5881 aaccacgcct tcgacctgct cttccccaag cgggcggccg cccacggcga gcagtgcgga 5941 ctcggcgcga ccttcgcgat gttcctgcgc ggagcgcacg aggagtcggc ctacatggcc 6001 caggtgctgc gccgccacgg ccttccggtc ctgccgcagg agatcggctt cacggtggac 6061 gagttcgtcc gtgccgtgga gttcgctccc gagacccggc cgggccgcta cacgatcctc 6121 gaacacctcg acctcaagac cgaacagatc aaggacatct acgccgacta tgtcaaggcc 6181 atcggtagct gaactcagac cggtcgtcca ccctccgggg gtgaaggacc ggcgcagcgg 6241 tgagcactgg atggggcgcc tctacatgcg tgaggtgtcc ctgcgggtcg accgctacct 6301 ggtcaacacc agggtcacgc ccaaccagct cacgtacctg atgaccgtct tcggggtgct 6361 cgccgccccg gccctgctgg tgccggggat cacgggcgcc gtgctcggcg tggtgtgcgt 6421 ccagatgtat ctgctgctgg actgcgtgga cggcgagatc gcccgctgga agaagcagta 6481 ctcgctgggc ggggtctatc tggaccgggt cggcgcgtat ctcaccgacg ccgccgtcct 6541 ggtcggcttc ggcctgcgcg ccgccgaccc gtggggcacc ggacgcatcg actggctctg 6601 ggccttcctc ggcacgctgg ccgcgctcgg cgcgatcctg atcaaggcgg agaccgacct 6661 cgtcggcgtc gcccggcacc agggcggtct gcctccggtg aaggagtcgg cgtccgaacc 6721 gcgctcctcc gggatggcgc tggcccgccg ggccgcctcg gcgctccagt tccaccggct 6781 gatcctcggt atcgaggcgt ccctgctgat cctggtgctg gcggtcgtcg accagctgcg 6841 cggcgacctg ttcttcaccc ggctcggcgt ggccgtgctg gccggcatcg cgctgctcca 6901 gaccctgctg cacctggtgt ccatcctcgc gtcgagcagg ctgaagtgag cgcgcccggg 6961 aaggtcggcg cggtcgtcat caccatgggc aaccgccccg acgagctgag agcgctgctg 7021 gactcgatcg ccaagcagga cggcgaccgg gtcgaggtgg tcgtggtcgg caacggctcg 7081 cccgtcccgg acgtccccga gggcgtcagg acgatcgagc tgcccgagaa cctcggtatc 7141 cccggcggcc gcaacgtcgg catcgaggcc ttcgggccca gcggccggga cgtcgacgtc 7201 ctgctgttcc tggacgacga cggtctcctg gcccaccacg acacggccga gctgtgccgc 7261 cgggccttcg ccgacgatcc gaggctgggc atcgtcagct tccgcatcgc cgacccggac 7321 accggtgtca cccagcgccg ccacgtaccc cggctgcgcg ccgcggaccc gatgcgctcc 7381 tcccgggtca ccaccttcct cgggggcgcc aacgccgtgc gcacgaaggt cttcgcggag 7441 gtgggcggac tcccggacga gttcttctac gcccacgagg agaccgacct ggcatggcgg 7501 gccctcgacg cgggctggat gatcgactac cggtccgaca tggtgctgta ccacccgacg 7561 accgcgccct cgcggcacgc ggtgtaccac cgcatggtcg cccgcaaccg ggtctggctg 7621 gcccggcgca accttcccgc cccgctggtc cccgtctatc tcggggtgtg gctgctgctc 7681 accctggtgc gccgtccctc ggggtccgcg ctgaaggcct ggttcggcgg tttccgggaa 7741 ggctggagca ctccgtgcgg acctcgtaga cccatgaagt ggcgtacggt gtggcggctg 7801 acccgactgg gccggccccc ggtgatctga caagctcgtc cctgagggca ccccgggccg 7861 taccgcgggc cccccggctc atgccggcct cgtcaaggct gcgcatcccg aagacgaaag 7921 tttcctacct gtgagtgaga caacgcatga cgtcggagtc gtggtgactg cgcctccgtc 7981 gcccgacgag ggcctcacgg cggcacagct ggccgccaag tacgggctgg ccgtgagcgg 8041 cgcccggcct ccgctgcggg agtacgtccg gcagctctgg gggcgccggc acttcatcat 8101 ggcgttctcc cgggcgaaac tggcctccca gtacagccag gccaagctcg gccagctgtg 8161 gcaggtggcc acaccgctgc tgaacgcggc cgtgtacttc atgatcttcg gcctgctcct 8221 caacgccggc cgcggcatga cgaaggaggt gtacatcccc ttcctcgtca cgggcgtctt 8281 cgtgttcatg ttcacgcaga gctcggtgat gaccggcgtc cgggcgatct cgggcaatct 8341 cggcctggtc cgcgccctgc atttcccgcg tgcctcgctg cccatctcgt tcgccctcca 8401 gcaactccag cagctgctgt actcgatgct cgtgctgttc atcgtggtga tcggcttcgg 8461 cagctacccg gacgcctcct gggcgctgat cgtcccgatc ctcgccctcc agttctgctt 8521 caactccggt ctggcgctga tcttcgcccg ggcgggcgcg aagaccccgg acctggcgca 8581 gctgatgccg ttcgtgatgc ggacgtggat gtacgcgtcc ggcgtgatgt tctccatccc 8641 cgtcttcctc gcggacaagc cgcagtgggt ggccaacatc ctgcagtgga acccggccgc 8701 catctacatg gacctgatgc gcttcgcgct catcgaggag tacagcgccg agaacctccc 8761 cgcgcacgtc tgggcggtcg cgggcggctg ggccgtcctc gtcgccctcg gcggcttcgt 8821 gtacttctgg caggcggagg agaggtacgg ccgtggttga gccgctcgcg ggacagcgga 8881 tcccgaccgt catcgccgac gacgtccaca tcgtctaccg cgtcaacggc gccaagtccg 8941 gccggggcag cgccaccgcg gcgctcagcc gcatcgtcaa gcgcggttcc gacgagtcgg 9001 cacgcggggt gcgcaaggtg cacgccgtgc gcggcgtctc cttcgtcgcc caccgcggcg 9061 aggccatcgg cctgatcggc tccaacggct ccggcaagtc cacgctgctg cgcgccatcg 9121 ccggtctgct gccgccggag agcggcaagg tctacaccga cggccagccc tcgctgctcg 9181 gcgtcaacgc ggccctgatg aacgacctca ccggcgagcg caacgtcacc ctcggcgggc 9241 tcgccatggg catgtcccgc gagcagatca aggagcgcta ccaggagatc gtcgacttct 9301 ccggcatcaa cgagaagggc gacttcatca ccctgccgat gcgcacctac tcctccggca 9361 tgcaggcccg actgcgcttc tccatcgcgg ccgccaagga ccacgacgtc ctgatgatcg 9421 acgaggccct ggccaccggc gacgccaagt tccgcaggcg ctccgaggcc cgggtgcggg 9481 agctgcgcga gcacgccggc acggtgttcc tggtcagcca cagcaaccag tccatccgcg 9541 acacctgtga ccgggtcctg tggctggaac gcggcgaact gcggctggac ggcccgaccg 9601 aagaggttct caaggagtac gagaagttct cgggcaagta gggcgattcg gccagggccc 9661 cgccggaact gtccggcggg gccctgcgtc tgcaaaggaa acgtcaactc cgcgtcagcc 9721 aaggaatctt gacgccaatc ggtgtgttgt tgtgatgtcc cggacacccc cgcgaaccgt 9781 gtcgcgttgt acaacgtaag ctggaccggc ccccgaatcg cgccaagtgg ggcgaaaacg 9841 tgcagtgcca ccgtcgggga cgctgcgcgg gcggctcggc ggcgtgtccg aaatagtgtg 9901 tattagatcg gcagtgtaga acgggagatg tgacggcgat ggctacggaa actccccagg 9961 tcgacgcgag ccgtgccgtc cccgctccgg acggccgacg atgacggcgc ccgccgcgcc 10021 gcgcatcggc gacccggagc gcggcacgct cgacaaggcc gcggacgaga acttcccggt 10081 ggcccccttc ttcctgccca gggcctggcg cgacgacctg atggccgtgt acggcttcgc 10141 ccggctcgtc gacgacatcg gcgacggcga cctcgccccc ggcggcgccg acgcccggct 10201 gctcggcgtg tcggccaccg ccgccgagga ccgcctcgcc ctgctggacg ccttcgaggc 10261 cgatctgcgc cgggtcttcg acggcacccc gcggcacccc ctgctgcgtc gcctccagcc 10321 cactgtccgc cgtcgctcgc tcggccccga gccctttctc ggcctgatcg ccgccaaccg 10381 gcaggaccag ctcgtcacgc gctacgagac ctacgacgac ctcctcgcgt actgcgagct 10441 gtccgccaat cccgtgggcc ggctggtcct cgccgtcacc ggcgccgcca cccccgagcg 10501 gatccgccgc tccgacgcga tctgcaccgc gctgcagatc gtcgagcatc tccaggacgt 10561 gtccgaggac ctgagccgcg accgtgtcta tctgcccgcc gcggacatga agcgctttca 10621 cgtcaaggaa tcggatctgg ccatgaacac cgcgggcgcg tcggtgcgcg cgctggtcgc 10681 gttcgaagcg caacgcgctc gcgatctgct gaatgaaggc gcccccctcg tgggtagcgt 10741 tcacggcagg ctgaggctgt tgctcgcggg tttcgtggcg gggggaagcg cggcgatcaa 10801 ggcgatcgcc gccgccggat acgacgtgct tcccggcccg cccaagcccg gcaggctccg 10861 gctgctgcgc gaggtgggcg tgaccctgcg aggagagggg tgatccgggc cgtggagccg 10921 tcaccacacg tgtccgcgcc ggtactcgcc gcctacggct actgcgagac cgtcaccgga 10981 cagcaggccc gtaacttcgc gtacggcatc cggctgctgc ccacgcccaa gcgccgcgcg 11041 atgtcggcgc tgtacgcctt ctcgcgccgc gtcgacgaca tcggcgacgg cgcactggac 11101 ggggaggtca agaccgccag gctggaggag acccgggcgc tgctcacccg ggtccgcgcg 11161 ggcgaggtcg aggaggacga caccgacccc gtcgcggtcg ccctcgcgca cacggcccgc 11221 gtcttcccca tcccgctgcg cggcctggac gagctgatcg acggcgtcct gatggacgtg 11281 cgcggcgaga cctatgagac ctgggacgac ctgaaggtgt actgccgctg cgtggcgggc 11341 gccatcgggc ggctctcgct cggggtgttc ggcaccgaac ggggggcgcg cggcgccgag 11401 cgcgcgccgg agtacgccga cacgctcggg ctcgcgctcc agctcacgaa catcctcaga 11461 gacgtccgcg aggacgccga gggcggccgc acctatctgc ccgccgacga cctcgcgaag 11521 ttcggctgtt cgaccgggtt cgacgggccg aagccgccgg agggatccga cttcgtgggg 11581 ctcgtgcact tcgaggtgcg gcgggcccgc gccctcttcg ccgaggggta ccggctgctt 11641 cccctgctcg accggcgcag cggcgcctgt gtcgccgcca tggcgggcat ctaccgccgt 11701 ctcctcgacc gcatcgagcg cgaccccgag gccgtgctgc gcggcagggt ctcgctgccc 11761 ggacgggaga aggccttcgt ggccgtacgc gggctgtcgg gcctggacgc ccggcacgtg 11821 tcgcggcgga ccgtcaggag gcacccgtga cggacgagac cggtgacaag gtgggccagg 11881 gtgattccac cggcgaaaag cggcacgcaa ccctccggtg cggcgcggcg tccctgactg 11941 cgacggccag cggtgcagag ttcaaacacc atggccggtc cgcacgggag ggtgcaggat 12001 gaacgacgag caactcgcgg acgccgcgga agcgtccggc ccttcggggc gtaccgccgt 12061 cgtcgtcggg ggagggctcg ccggggtgac cgccgcgctc gcgctcgccg acgcgggcgt 12121 acgcgtcacg ctgctcgaag gccggccccg gctcggcggc ctggccttct ccttcacgcg 12181 cggcgaactg accgtggaca acggacagca cgtgtacctg cgctgctgca ccgcctaccg 12241 ctggttcctc gaccgcatcg agggcagcgc gctggcgccc ttgcaggatc gtctcgacgt 12301 gcccgtcgtc gacgtggccg cgcccgaggg acgacggctc ggcaggctgc ggcgcgacgc 12361 gctgcccgtg cccctgcacc tggggcgcag cctcgccacg tatccgcatc tctcgctcgc 12421 cgaacgggcc agggtgggcc gtgccgcgct cgcgctcaag gggctcgacc tcgccgatcc 12481 gcgactggac gcacaggact tcggcagctg gctgaccgcg cacggtcagt cggcgcgcgc 12541 cgtcgaggca ctctgggacc tggtcggggt cgccacgctc aacgcggtcg ccggagactc 12601 ctcgctgggg ctcgccgcga tggtgttcaa gaccggtctg ctgtccgacc cgggcgccgc 12661 cgacatcggc tgggcgcatg tcccgctggg cgaactgcac gaccggctcg cccgcaaggc 12721 gctcgactcc gccggcgtgc gtaccgaggt ccgtacacgc gtcacctccc tctcttccga 12781 cgacaacggg acgtggagcg ttcaggttcc cggcgagacg ctccgcgcgg acacggtcgt 12841 cctcgccgta ccgcagcgcg aggcctacga cctgctcccc gccggggcgc tcgaccacgc 12901 cgagcggctg ctggagatcg gcaccgcgcc catcctcaac gtgcacgtcg tctacgaccg 12961 caaggtgctc gacaagccct tcttcgcggc gctcggcacg cccgtgcagt gggtcttcga 13021 ccgcaccgcc gcctccgggc tgcgcgaggg ccagtacctc gccctgtccc agtccgcggc 13081 gcacgacgag atcgacgaac ccgtggccgc gctgcgcgag cgctatctgc ccgagctgga 13141 acggctcctg ccgcgcacgc gcggcgccgg ggtgcgggac ttcttcgtga cccgggaacg 13201 cacggcgacg ttcgccccca cccccggcgt cgggcgcctt cggcccggcg cccgcaccag 13261 aacccccggc ctgtacctgg ccggagcgtg gaccgccaca gggtggcccg cgaccatgga 13321 gagtgcggtc cgcagcggtg tcagcgcggc ggacgccgcg ctgagcgccc tcggccggcc 13381 ccgcccccgc cgcctcttcg agttcgagga ggcggcctga tgctcgatca gcacggctcg 13441 gcacaccccc gcaccctctc cagcaccgca acaagaggag aaaacgtgcc cactgtgccc 13501 ccggccacgc cggccgctcg gaggaccgcg gtggacgtga ccgcgctcct ggagcgcggc 13561 cgcaccctgg ccacaccggt gctgcgggcg gccgtcgacc gtctggcacc gcccatggac 13621 acggtcgccg cctaccactt cggctggatc gacgcccacg gcaacccgac cgacggtgac 13681 ggcggcaagg ccgtgcgtcc cgccctcgcc gtgctctccg ccgaggtcgc cggggcggcc 13741 cccgaggtcg gagtccccgg cgcggtcgcc gtcgagctgg tccacaactt ctcgctcctg 13801 cacgacgacc tgatggacgg cgacgagcag cgcaggcacc gcgacaccgt ctggaaggtg 13861 cacggccccg cccaggccat cctggtcggc gacgccctgt tcgccctcgc gggcgagatc 13921 ctcctcgaac tcggcacggc cgaggcggcc cgggcgaccc accgcctgac cgtcgccacc 13981 cgtgccctca tcgacggcca ggcccaggac atctcctacg agcaccgcga ccgggtcagc 14041 gtcgaggagt gcctggagat ggagggcaac aagaccggtg ccctgctggc ctgcgccagt 14101 tccatcggcg ccgtgctcgg cggcgcggac cggcacaccg ccgacgccct ggagaagtac 14161 ggctaccacc tcggccttgc cttccaggcc gtggacgacc tgctcggcat ctggggcgac 14221 ccggagtcca ccggcaagca gacgtggagc gatctgcgtc agcgcaagaa gtccctgccg 14281 gtggtcgccg cgctcgcggc cggcggttcc gcctccgagc ggctcgggga gatcctcgcc 14341 gccgacgcca agagcagcga cttcgagacc ttctccgagg gggagttcgc ggcccgcgcc 14401 gcgctgatcg aggaggcggg gggccgtgac tggaccgccg gggaggcgcg ccgccagcac 14461 gccgtggccc tggacgccct gaacgccgtg gacatgtccg agcaggtgcg cgaccggttc 14521 acggcgctcg ccgacttcgt cgtcgtacga aagagatgat ccctatcggt cgaatagccc 14581 tcgcgtagtc gccggccggt gtgtgaggag agagcaccgg ccgacggcgg acccacagca 14641 gacgcaaagc catgcacact gcacgaaggg gaagccatga cagcgacgac cgacggaagc 14701 accggggctc tgccgccccg cgctgccgcg gccagcgaaa ccgacatcat catccccgtg 14761 gcggccgggg tacaagaagc cgccacccgc gcgatgcaac gcgccaccga cttcctgctc 14821 gccgggcagg acgccgaggg ctggtggaag ggcgacctcg agacgaacgt cacgatggac 14881 gccgaggacc tgctgctccg tcagttcctg ggcatccgcg acgaggccac gacccgggcc 14941 gccgcgctct tcgtccgggg cgagcagcgc gaggacggca cctgggccac cttctacggc 15001 ggtccgcccg acctctccgc caccgtcgag gcgtacgtcg ccctgcggct ggcgggcgac 15061 gcccccgagg cgccccacat gcgccgggcc tccgggtgga tccgcgagca ggggggcatc 15121 gcctccgccc gggtcttcac ccggatctgg ctggccctgt tcggctggtg gaagtgggag 15181 gacctgcccg aactcccgcc ggagctcctg ttcttcccca agtggttccc gctgagcatc 15241 tacaacttcg gctgctgggc gcgccagacg atcgtgccgc tcaccgtggt gtcggcgaag 15301 cgcccggtgc gtccggcgcc cttcccgctc gacgagctgc acaccgatcc cgcccgtccc 15361 aacccggcca ggcccctcgc cccggtgaac agctgggacg ggctgttcca gcggctcgac 15421 aaggtcgtac gcggctaccg gtcggtcgcg gtgcgcaggc tgcgcggcgc ggccctgaac 15481 gccgccgccc gctggatcat cgaacggcag gagaacgacg gcgcctgggg cggcatccag 15541 ccgccggccg tgtactcggt gatcgcgctg cacctgctcg gctacgacct ccggcacccg 15601 gtgatgcggg ctggcctcga gtcgctggac cggtacgccg tgtggcgcga ggacggcgcg 15661 cggatgatcg aggcctgtca gtcgccggtg tgggacacct gtctggcgac catcgcgctg 15721 gccgacgcgg gacttcccgc cgaccatccc caactggtca aggccgccga ctggatgctc 15781 ggcgaacagg tcgtccggcc gggcgactgg tcggtgagca ggcctcaact gccgccgggc 15841 ggctgggcgt tcgagttcca caacgacaac tatcccgaca tcgacgacac cgccgaggtc 15901 gtcctcgcgc tgcgccgggt caagcaccac gacccggagc ggatggaccg ggccatcgcg 15961 cgcggcgtgc gctggaacct cgggatgcag tcgaagaacg gcggctgggg cgccttcgac 16021 gtcgacaaca ccagcccgtt ccccaaccgg atgcccttct gcgacttcgg agaggtcatc 16081 gacccgccgt ccgccgacgt caccgcgcac gtggtcgaga tgctggcggt cgaggggctc 16141 tcgcacgacc cgcgtacccg gcggggcatc gagtggctgc tggccgaaca ggagccggac 16201 ggctcgtggt tcgggcgctg gggcgtcaac tacgtctacg gcacagggtc ggtggtgccg 16261 gccctcaccg cggcgggcct gcccgcgcag caccccgcga tccgacgggc cgtctcctgg 16321 ctggagcggg tgcagaacga cgacggcggc tggggcgagg acctgcgctc ctaccaggac 16381 gccacccgct ggagcggccg gggcgcctcc acggcctccc agaccgcctg ggcactgatg 16441 gcgctgctgg cggccgggga gagggactcc aaggccgtcg agcggggcgt cgcctggctg 16501 gcgcagaccc agcgggagga cggctcctgg gacgagccct acttcaccgg caccggcttc 16561 ccctgggact tctcgatcaa ctaccacctc taccggcagg tcttcccgct gaccgcgctc 16621 ggccggtacg tccacggaga gccgttcagc aagcagcccg ccacccacgc ggcttccgcc 16681 gaggtcaagg ggagctgatg agcacacagt ccgtcccgtc gccgctgctg atcgcctgcg 16741 ccctcggcat cgagcacctc gccctgcgca tgggcgagcg cggcggagcc gacgggccgg 16801 tcaccgtcct gcggacgggc atggggccga aggccgcgga gcgctccgtc acccgcctcc 16861 tggccgaccc gctgttcgcg ggcgcggccg tgctggccac gggtttctgt gccggcctcg 16921 ccccgggcat gcaccccgga gacctggtcg tcgccgagga gacccgcgac ccgcgcggca 16981 gtgtcccctg tgtcggcacc gagctgctcg tcaaggaact cgcccgcacc ctgcccgggc 17041 ggaccgtcca caccggtccc ctcaccggct ccgaccacgt cgttcgcggt catgagcggg 17101 ccgacctgct cgcgaccggc gcgatcgccc tcgacatgga atcggcggcc acgctgctga 17161 gcgcagtgcg cgccgagccg cgcccggttg cggccgtccg ggtggtcgtg gacgctcctg 17221 aacatgaact cgtccggatc ggcacggtac gcggtggaat atctgccttc cgcgtccttc 17281 gctcggtcct gcctgctttt ttcgaatggc accgtaatgt tctgctcccc cggaggtgag 17341 ccacatggcc atgccactgc gccagtccat caaggtcgct acatacctgg ccgaacagaa 17401 gctccgcaag cgggagaagt ttccgctcat cgtcgagctg gaaccgctct tcgcctgcaa 17461 cctcaagtgc gagggctgcg gcaagatcca gcacccggcg ggagtgctca agcagcgcat 17521 gccggtcgcc caggccgtgg gcgcggtgct ggagtccggt gcgccgatgg tgtccatcgc 17581 gggcggcgag cccctgatgc accctcagat cgacgagatc gtgcggcagt tggtggccaa 17641 gaggaagtac gtcttcctct gcaccaacgc catgctgctg cgcaagaagc tggacaagtt 17701 cacgccctct ccctacttcg ccttcgccgt gcacatcgac gggctgcgtg agcggcacga 17761 cgagtcggtg gccaaggaag gcgtgttcga cgaggccgtg gcggccatca aggaggccaa 17821 gcagcgcggc ttccgggtga ccaccaactc gaccttcttc aacaccgaca ccccgcagac 17881 catcatcgag gtgctcaact acctcaacga cgacctcaag gtcgacgaga tgatgatctc 17941 gcccgcctac gcctacgaga aggctcccga ccaggagcac ttcctcggcg tggagcagac 18001 ccgcgagctg ttcaagaagg ccttctcggg tggcaaccgg cgccgctggc ggctcaacca 18061 ctcaccgctg ttcctcgact tcctcgaggg caaggccgac ttcccgtgca cggcgtgggc 18121 gatccccaac tactcgctgt tcggctggca gcggccctgc tacctgatga gcgacgggta 18181 cgtgccgacg taccgcgagc tgatcgagga gacggactgg gacaagtacg gccgcggcaa 18241 ggacccgcgc tgcgccaact gcatggcgca ctgcggctac gagcccaccg ccgtcctggc 18301 caccatgggc tcgctgaagg agtccctgcg cgccctgcgc gagacagtca acggaaaccg 18361 ggagtgacga catgaccgcg gtctccctgg gcgtccccgg gatgccggtc cggccggtgg 18421 cgtcgcggcg tgagtcgcgg cggatccagg tcgggccggt ggcggtcggg ggcggggccc 18481 cggtgtcggt gcagtcgatg acgacgacgc gtacgtcgga catcggcgcc accttgcagc 18541 agatcgcgga actcaccgcc tccggctgcc agatcgtccg cgtcgcctgc cccacgcagg 18601 acgacgcgga cgccctcgcg accatcgccc gcaagtccca gatcccggtg atcgcggaca 18661 tccacttcca gccgaagtac gtgttcgccg cgatcgaggc gggctgcgcc gcggtccggg 18721 tgaaccccgg caacatcaag cagttcgacg acaaggtgag ggagatcgcc aaggcggcga 18781 aggagcacgg caccccgatc cgcatcggcg tcaacgccgg ctcgctggac cgccgcc //