LOCUS       NZ_LMEQ01000001        10456 bp    DNA     linear   CON 07-JUN-2024
DEFINITION  Streptomyces sp. Root1310 contig_1, whole genome shotgun sequence.
ACCESSION   NZ_LMEQ01000001
VERSION     NZ_LMEQ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. Root1310
  ORGANISM  Streptomyces sp. Root1310
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2227698)
  AUTHORS   Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E.,
            Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M.,
            Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P.
  TITLE     Functional overlap of the Arabidopsis leaf and root microbiota
  JOURNAL   Nature 528 (7582), 364-369 (2015)
   PUBMED   26633631
REFERENCE   2  (bases 1 to 2227698)
  AUTHORS   Garrido-Oter,R. and Bai,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ,
            Carl-von-Linne-Weg 10, Cologne 50829, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. 20140604
            Assembly Name                     :: Root1310
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001426425.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 02:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,470
            CDSs (total)                      :: 8,385
            Genes (coding)                    :: 8,123
            CDSs (with protein)               :: 8,123
            Genes (RNA)                       :: 85
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 262
            CDSs (without protein)            :: 262
            Pseudo Genes (ambiguous residues) :: 0 of 262
            Pseudo Genes (frameshifted)       :: 98 of 262
            Pseudo Genes (incomplete)         :: 219 of 262
            Pseudo Genes (internal stop)      :: 20 of 262
            Pseudo Genes (multiple problems)  :: 64 of 262
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:32:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1218191
            Orig. end                         :: 1228647
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LMEQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10456
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="3"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10456
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10456
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5456](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5456)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            273..2132
                     /locus_tag="ASD48_RS05340"
                     /old_locus_tag="ASD48_05330"
     CDS             273..2132
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132945.1"
                     /locus_tag="ASD48_RS05340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05330"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_057600180.1"
                     /transl_table=11
                     /translation="MTNARRHPRSTTADSVLTEVAEAVRLQEGPPGVRSVLRALRRLAP
                     ASTKDLSRATGLPVPIVAALGNELRRRGFVTTQRPSRLTEAGLDLVAQLGMDLSLDATC
                     TTCDGRELVIPDVLDEAVLRLRALMESGPAADMAIDQSHCTAETKVRRVLALLTAGTLP
                     GGSLLLIGDDDLVSLAVAVVGDVLGGPIVEQVTVVDISPEILDYIRKASAGLGTRIETV
                     QHDLRLPLPDELHAQHDVAMTDPPYTAEGARLFLSRAVEGLRPGPSHSVFFSFGGKSPD
                     EMLEVQREIMGLGLVTNGFVRNFNEYEGSGILGGIGFFQHLLTTTSTAPTHAGEFSGPL
                     YTGDKRTRQREYTCVACDARFRVGPGARWTAVAALREEGCPNCGKGPFRPGRLVPAEDP
                     ATPAEQPPAPVRAPVQSPVQVPGQQAAPAPVPAPAAPVGRTHGWRPPAEQDRAALAERA
                     RPYVTRQADERDLPAIGRFEAEIARVSFGEDAIDDPARWESRLGRAMEKSKEGMIVAHG
                     PGEEPVGWCWVSINQNAMTGDRYANFRSLAVSPVDNRSDVAELLLTAGLEFCLARGITE
                     VVGRVHVGNVPMRTVYRKFGFDPTSLSMKLFLPEGEPEGESAR"
     gene            2129..3271
                     /locus_tag="ASD48_RS05345"
                     /old_locus_tag="ASD48_05335"
     CDS             2129..3271
                     /NRPS_PKS="Domain: FkbH (12-133). E-value: 3.8e-17. Score:
                     54.4. Matches aSDomain:
                     nrpspksdomains_ASD48_RS05345_FkbH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1256: FkbH like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132944.1"
                     /locus_tag="ASD48_RS05345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05335"
                     /product="HAD-IIIC family phosphatase"
                     /protein_id="WP_057600181.1"
                     /transl_table=11
                     /translation="MSVTDGFDPDGVKCVVWDLDGTLWDEIAVESATDDLPTPRPEALA
                     AIDALAARGVLSSIASRSAPSVLDRLDAVPEVRARFLAPQVSWQDKSESLRRIAKDLGI
                     AVDALVLVDDSPYERAEVEALLPGVRTLAPEDVTALLAAFEGREVTAESRERVRRYRTE
                     ETRRAEGERFEGSREEFLRWCDMRLSVGAATADEIPRALELAARTHRLNSSGLTPDRLR
                     ELASSDGHELYTARMTDRFGEYGIIGAALVDRTRRADRGTPATWSVPLLALSCRVAGRG
                     AAAAFLFRLMERAREAGAEEFRVTLRPTDANLEMRILLRQAGLRRTDAPATATTTGVGD
                     ATPTARATTADSAVLGRTLQGDLPGSPAWLHVSDREDAEA"
     aSDomain        2165..2527
                     /aSDomain="FkbH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS05345_FkbH.1"
                     /evalue="3.80E-17"
                     /label="ASD48_RS05345_FkbH.1"
                     /locus_tag="ASD48_RS05345"
                     /protein_end="133"
                     /protein_start="12"
                     /score="54.4"
                     /tool="antismash"
                     /translation="KCVVWDLDGTLWDEIAVESATDDLPTPRPEALAAIDALAARGVLS
                     SIASRSAPSVLDRLDAVPEVRARFLAPQVSWQDKSESLRRIAKDLGIAVDALVLVDDSP
                     YERAEVEALLPGVRTLA"
     gene            3268..3546
                     /locus_tag="ASD48_RS05350"
                     /old_locus_tag="ASD48_05340"
     CDS             3268..3546
                     /NRPS_PKS="Domain: PP-binding (12-81). E-value: 6e-10.
                     Score: 31.3. Matches aSDomain:
                     nrpspksdomains_ASD48_RS05350_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132943.1"
                     /locus_tag="ASD48_RS05350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05340"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_057600182.1"
                     /sec_met_domain="PP-binding (E-value: 2.1e-07, bitscore:
                     28.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIRERAAVERELRSLIAEAARLDEAVVAELPADTDLFGPEIGL
                     TSLAGVTLLGTVDKRYGVDVAALDLSLDSLQSIATLTDFVATHLQSH"
     aSDomain        3304..3510
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASD48_RS05350_PP-binding.1"
                     /evalue="6.00E-10"
                     /label="ASD48_RS05350_PP-binding.1"
                     /locus_tag="ASD48_RS05350"
                     /protein_end="81"
                     /protein_start="12"
                     /score="31.3"
                     /tool="antismash"
                     /translation="ELRSLIAEAARLDEAVVAELPADTDLFGPEIGLTSLAGVTLLGTV
                     DKRYGVDVAALDLSLDSLQSIATL"
     gene            3687..3998
                     /locus_tag="ASD48_RS05355"
                     /old_locus_tag="ASD48_05345"
     CDS             3687..3998
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132942.1"
                     /locus_tag="ASD48_RS05355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05345"
                     /product="chaplin"
                     /protein_id="WP_057600183.1"
                     /transl_table=11
                     /translation="MSRIAKVAAVALGTSAVVVSGAGLAMADAGAQGAAVGSPGVLSGN
                     VVQVPVHIPVNVCGNSVSVIGLLNPAFGNACLNVSDHDKGGDKHHDKHGDKHGGGYGG"
     gene            complement(4151..5017)
                     /locus_tag="ASD48_RS05360"
                     /old_locus_tag="ASD48_05350"
     CDS             complement(4151..5017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="ASD48_RS05360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05350"
                     /product="tyrosinase family protein"
                     /protein_id="WP_057600185.1"
                     /transl_table=11
                     /translation="MAYTRKDVSTLTSAERRRFVKALLEIKRKGEYDEFVRMHIDYYVS
                     DGDGGLRTAHMAPSFLPWHRRFLLDLEQALRRVDSSVTVPYWDWTRDRTATASPWTEDL
                     LGGNGRRSDHRVTTGPFAYATGAWTIKENVTDGDFLTRDLGRAAAPIGLPTGSDVERAL
                     QDPVYDAEPWDSTVTRGFRNKLEGWGTGSGSAAWRNHNRVHRWVGGVMLGGASVNDPVF
                     WLHHAFVDLLWTRWQRRHREHRYLPAEPPGPTSRQYRRVVARREKLPPWDVTPDQLEDA
                     SRIYRYA"
     gene            complement(5001..5456)
                     /locus_tag="ASD48_RS05365"
                     /old_locus_tag="ASD48_05355"
     CDS             complement(5001..5456)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132940.1"
                     /locus_tag="ASD48_RS05365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05355"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_242432509.1"
                     /sec_met_domain="melC (E-value: 9.5e-45, bitscore: 149.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVPVVTGRPRTAHGARRRDLLRGLLGAAAALAIVPVVSASRPS
                     RPVAEGPTDSFDETYRGRRIQGVLAATGTAAEADVPWDITVDGRPLPLMRRADGTWLSM
                     VDHYSSYATPLEAARAAVDGLGPGERLRAADPVHRHPHMGGHHGLHP"
     gene            complement(5756..6277)
                     /locus_tag="ASD48_RS05370"
                     /old_locus_tag="ASD48_05360"
     CDS             complement(5756..6277)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="ASD48_RS05370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05360"
                     /product="hypothetical protein"
                     /protein_id="WP_057600189.1"
                     /transl_table=11
                     /translation="MKSTTRGTLAAVITCVAAAAGAAASVTPAAAIGTVPVPVPLDGVE
                     KSLNVELPTIGGEIPLPTPGAPEGPRFVEGRLIPERVVPQLPVAAGLPGVGLRAPLPEV
                     LGSDFNHLGLDAPASDLRTLSPGLALEAPLTAPNPDRYGLPDPRLPQAGVITPVLQAVP
                     GANLGVDEGL"
     misc_feature    6341..6352
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.12"
                     /tool="antismash"
     gene            complement(6446..7042)
                     /locus_tag="ASD48_RS05375"
                     /old_locus_tag="ASD48_05365"
     CDS             complement(6446..7042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132938.1"
                     /locus_tag="ASD48_RS05375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05365"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_057600190.1"
                     /transl_table=11
                     /translation="MPRPHPAPAGGGRAYALLLVLTGAAGLLAAWVITLDKFKLLEDPG
                     FTPGCSLNPVVSCGSVMTSDQASAFGFPNPMLGLVAYGIVVCVGVSLLAGAVFPRWYWL
                     TFTGGCLFGVGFVSWLQFESLYRINALCLWCCLAWVATILMFWYAVAFDVRHAFLPAPA
                     GVRNFLDEFTWVPPLLHIGVIGMLILTRWWDFWTS"
     gene            complement(7042..7542)
                     /locus_tag="ASD48_RS05380"
                     /old_locus_tag="ASD48_05370"
     CDS             complement(7042..7542)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065676.1"
                     /locus_tag="ASD48_RS05380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05370"
                     /product="DUF5949 family protein"
                     /protein_id="WP_057600192.1"
                     /transl_table=11
                     /translation="MTSTPSATRPFRVADLGTLVVMPWSGEAPDGSDMPYLLAYSLGDT
                     EEGPEGTAVAVARLLTDNGMPVGGDVVDGTERPSLPFTLLVESGAAVLNMPGLNAQCLP
                     PQEWLAAVEQRGYAYLVLTTRAWPEAVPGRAVTPDQLAAFAGAHETLTAAAHIVLPARS
                     LRG"
     gene            complement(7712..7999)
                     /locus_tag="ASD48_RS05385"
                     /old_locus_tag="ASD48_05375"
     CDS             complement(7712..7999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116485.1"
                     /locus_tag="ASD48_RS05385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05375"
                     /product="hypothetical protein"
                     /protein_id="WP_057600194.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSIVLAGAAAPAFATPADLTPTSLNGAVDTLARG
                     PINLEDAMPVQHQSDALDTENKDSVLSTVKGATGALNSHTGLLGGLPLRG"
     misc_feature    complement(8037..8052)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.85"
                     /tool="antismash"
     gene            complement(8174..9067)
                     /locus_tag="ASD48_RS05390"
                     /old_locus_tag="ASD48_05380"
     CDS             complement(8174..9067)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003503.1"
                     /locus_tag="ASD48_RS05390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05380"
                     /product="hypothetical protein"
                     /protein_id="WP_057600197.1"
                     /transl_table=11
                     /translation="MRGLPVRRIASTALCATLVLGISGPAAMAADGAAAHERKVASSNT
                     PVAGTDALLAQAQGLGELGTVLTPVANLLNTVLKAEDGQLTAEQATELGDAVKAAVAKI
                     TAATPATPATPATPATPATPADPEAEPADPAAAVPAKPEVPADPAAEVPAKPADPAAAV
                     PAKPAVPADPAVVLPAKPAVPADSAVVLPAKPAAPADAAAALPAKPVLSKGGDDAKAKA
                     AADPVADAVAALDKAVAALLAAATSLDVSQVAPAVTGVVSGLLDLVSATLAGAGLTLPT
                     LPAEAPAAAVPAVPAG"
     misc_feature    complement(9140..9153)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.53"
                     /tool="antismash"
     gene            complement(9353..9592)
                     /locus_tag="ASD48_RS05395"
                     /old_locus_tag="ASD48_05385"
     CDS             complement(9353..9592)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449696.1"
                     /locus_tag="ASD48_RS05395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ASD48_05385"
                     /product="chaplin"
                     /protein_id="WP_057600199.1"
                     /transl_table=11
                     /translation="MSRIAKGLVLTSVAAAAVAGASGIAAADSGASGVAEHSPGVLSGN
                     VVQVPVHIPVNVCGNTVNVIGLLNPAFGNTCIND"
     misc_feature    9606..9622
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.12"
                     /tool="antismash"
     misc_feature    9612..9625
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.12"
                     /tool="antismash"
     misc_feature    9789..9804
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.02"
                     /tool="antismash"
ORIGIN
        1 acggaacgcg taccgcctgc actggactcc gtatcaccgg ctcgaatgcc gccctgttcc
       61 cgccccgttc ccgctctatt cccgttccgt tcccgtccag ttcccgatgc gatccccatc
      121 cgaccctcat ccgaccctca tccgattacg gtcgaattcc gcatcgactc ccgttccgtt
      181 cccgaccgtc cgagtgggtc cggagggccg cgtaccagcc cgtatactcg atagtcccgg
      241 aatccaccaa tcagcttgcc tggagcagca ttgtgacgaa cgcgcgtcgg caccctcgga
      301 gcaccaccgc ggattccgta ctcacggaag tcgcggaagc cgtccggctc caggagggcc
      361 cgcccggagt gcggtccgtc ctgcgggcgc tgcgtcgtct ggcgcccgcg tccacgaagg
      421 acctcagccg cgcgacgggg ctgcccgtcc cgatcgtggc cgccctgggg aacgaactgc
      481 gccgccgggg attcgtcacc acacagcgtc cgtcccggct gaccgaggcc ggtctggacc
      541 tcgtcgccca gctcggcatg gacctgtccc tcgacgccac ctgcaccacc tgtgacgggc
      601 gcgagctcgt catccccgac gtcctggacg aagccgtgct gcggctgcgt gccctcatgg
      661 agtcgggtcc cgccgcggac atggcgatcg accagtcgca ctgcacggcc gagaccaagg
      721 tgcgccgggt gctcgcgctg ctcacggcgg gcacgctgcc cggcggctcc ctgctgctga
      781 tcggcgacga cgacctggtg tccctcgccg tcgccgtggt gggggacgtg ctcggcggtc
      841 cgatcgtcga gcaggtgacg gtcgtggaca tctccccgga gatcctcgac tacatccgca
      901 aggcgtcggc cggcctcggc acccgtatcg agaccgtcca gcacgacctg cgcctgccgc
      961 tgcccgacga gctccacgcg cagcacgacg tggccatgac ggacccgccg tacaccgcgg
     1021 aaggcgcccg cctcttcctc tcccgtgccg tggaagggct gcggcccggc ccctcgcaca
     1081 gcgtcttctt ctcgttcggc ggcaagagcc ccgacgagat gctggaggta cagcgcgaga
     1141 tcatggggct gggcctggtc accaacggtt tcgtccgcaa cttcaacgag tacgagggca
     1201 gcggcatcct cggcggtatc ggcttcttcc agcacctgct cacgacgacg tccacggccc
     1261 ccacccacgc gggcgagttc agcggtcccc tctacacggg cgacaagcgg acccggcagc
     1321 gcgagtacac gtgcgtggcg tgcgacgccc gtttccgcgt cgggccgggc gcccgctgga
     1381 ccgcggtcgc cgccctgcgc gaggagggct gcccgaactg cggcaagggc cccttccgcc
     1441 ccggccgcct ggtcccggcg gaggatccgg ccaccccggc cgagcagcct cccgccccgg
     1501 tccgggcccc cgtccagagc ccggtacagg tccccggcca gcaggcagcc cccgccccgg
     1561 ttccggcccc ggccgctccc gtcggccgca cccatggctg gcgtccgccg gccgagcagg
     1621 accgcgccgc cctcgccgag cgggcccggc cgtacgtcac ccgccaggcc gacgagcgcg
     1681 acctgccggc catcgggagg ttcgaggccg agatcgcccg ggtctccttc ggcgaggacg
     1741 ccatcgacga ccccgcgcgg tgggagtccc gcctcggccg tgccatggag aagtcgaagg
     1801 agggcatgat cgtcgcccac ggcccgggcg aggagcccgt cggctggtgc tgggtgagca
     1861 tcaaccagaa cgcgatgacc ggcgaccgct acgccaactt ccgttcgctg gccgtgtccc
     1921 cggtggacaa ccgcagcgac gtcgccgaac tcctcctcac cgccggtctg gagttctgcc
     1981 tggcccgcgg catcaccgag gtcgtcggcc gggtgcacgt gggcaacgtc ccgatgcgca
     2041 cggtgtaccg caagttcggc ttcgacccca ccagcctgtc gatgaaactg ttcctccccg
     2101 agggcgagcc ggagggagaa agcgcccgat gagcgtcacg gacggcttcg atcccgacgg
     2161 cgtcaagtgc gtcgtgtggg atctcgacgg caccctgtgg gacgagatcg ccgtcgagtc
     2221 ggccaccgac gacctgccca cgccccgccc cgaggcgctc gccgcgatcg acgccctggc
     2281 ggcccgcggt gtgctcagca gcatcgcgag ccgcagcgcg ccctcggtgc tcgaccggct
     2341 ggacgccgta cccgaggtgc gggcgcgctt cctggccccg caggtgtcct ggcaggacaa
     2401 gagcgagtcg ctgcgcagga tcgcgaagga cctcggcatc gcggtggacg ccttggtcct
     2461 ggtcgacgac tccccgtacg agcgcgccga ggtcgaggcc ctcctgccgg gcgtgcgcac
     2521 cctcgcgccg gaggacgtga ccgcgctgct ggccgcgttc gagggccggg aggtcaccgc
     2581 cgagtcccgc gaacgcgtgc gccgctaccg cacggaggag acccgcaggg ccgagggcga
     2641 acgcttcgag ggctcgcgcg aggagttcct gcgctggtgc gacatgcgcc tcagcgtcgg
     2701 cgcggccacg gccgacgaga tcccgcgcgc gctggagctc gccgcccgta cccatcggct
     2761 gaactcctcc gggctcaccc ccgaccgcct gcgcgagctg gcctcctcgg acggccacga
     2821 gctgtacacc gcccgcatga cggaccgttt cggcgagtac ggcatcatcg gcgccgccct
     2881 cgtcgaccgc acccggcgcg ccgaccgcgg cactccagcc acctggtccg tcccgctgct
     2941 cgcgctctcc tgccgggtgg ccggccgggg cgcggcggcg gccttcctgt tccggctgat
     3001 ggagcgggcc cgcgaggccg gcgccgagga gttccgggtg accctgcgcc ccacggacgc
     3061 caacctggag atgcgcatcc tgctccgcca ggcgggcctg cgccgcacgg acgcccccgc
     3121 cacggccacg accaccggcg tcggcgacgc cacccccacc gcccgtgcca ccaccgcgga
     3181 ttcggcggtc ctgggcagga cacttcaggg cgacctcccc gggtcacccg cgtggctgca
     3241 cgtatccgac cgagaggacg ccgaagcgtg acggacatcc gagagcgggc cgcggtggaa
     3301 cgggaactcc gttcactgat cgccgaggcg gcccgtctgg acgaggcggt ggtcgcggaa
     3361 ctccccgccg acaccgacct gttcggaccg gagatcggcc tcacctcgct ggccggcgtg
     3421 accctgctgg gcacggtcga caagcgctac ggcgtcgacg tggccgcgct ggatctgagc
     3481 ctggacagcc tccagtccat cgccaccctc accgacttcg tcgcgacaca tctccagtcg
     3541 cactagccac ccgactgtac gaccgtcctg ttcaaaaagg gtgatccgtc cgaacgtacc
     3601 gtgaccggct cacggtgtcg gcgttgaacg gggagtgcgg cggcgccccc tgccaccgca
     3661 cgaaccgatt ccctaaggag aacgtgatgt ctcgcatcgc gaaggtggcc gctgttgccc
     3721 tcggcaccag cgccgtggtg gtcagcggag ccggcctggc catggcggac gcgggtgcgc
     3781 agggcgcggc cgtgggttcg ccgggtgtcc tgtcgggcaa cgtcgtccag gttccggtcc
     3841 acatcccggt caacgtctgc ggcaacagcg tcagcgtcat cggcctgctc aacccggcct
     3901 tcggcaacgc ctgcctcaac gtcagcgacc acgacaaggg tggcgacaag caccacgaca
     3961 agcacggtga caagcacggc ggcggctacg gcggctgagc ttcaccccgt acgtcccgga
     4021 cgtacacccc ggtcgtaccc cgcgtacgta ccaccaggag agccccggca cctcgagcgc
     4081 cggggctctc cccctgtccg cgggcggttc accgcgacgg gtacaccccg acgggctcac
     4141 cgcgacccgc tcacgcgtac cggtagatcc gggacgcgtc ctccaactgg tccggggtca
     4201 cgtcccacgg gggcagcttc tcccgccggg cgacgacccg gcggtactgg cggctggtcg
     4261 gccccggcgg ttcggcgggc aggtagcggt gttcgcggtg cctgcgctgc cagcgggtcc
     4321 acagcaggtc gacgaaggcg tggtgcagcc agaagacggg gtcgttgacc gacgcgccgc
     4381 cgagcatgac cccgccgacc caccggtgca cccggttgtg gttgcgccag gcggcgctgc
     4441 ccgagccggt gccccatccc tccagcttgt tgcggaagcc ccgggtgacc gtcgagtccc
     4501 agggctcggc gtcgtagacg gggtcctgga gcgcccgctc cacgtcgctt ccggtgggca
     4561 ggccgatcgg ggcggcggcg cggccgaggt cccgggtgag gaagtccccg tcggtcacgt
     4621 tctccttgat ggtccaggcg ccggtggcgt aggcgaacgg accggtcgtc acccggtggt
     4681 cggagcgccg tccgttgccg ccgagaaggt cctcggtcca gggcgaggcc gtcgcggtgc
     4741 ggtcgcgcgt ccagtcccag tagggcaccg tcaccgagga gtcgacccgg cgcagtgcct
     4801 gctcgaggtc cagcaggaat cggcggtgcc agggcaggaa ggagggcgcc atgtgggccg
     4861 tccgcagacc tccgtcgccg tcggacacgt agtagtcgat gtgcatgcgg acgaactcgt
     4921 cgtactcgcc cttccgtttg atctccagca gcgccttcac gaagcgccgt cgctcggcgc
     4981 tggtgagggt gctgacgtcc ttacgggtgt aggccatggt gtccccccat gtgcgggtgt
     5041 cggtgtactg gatccgccgc gcgcagccgc tctcccggac cgagcccgtc cacggctgcg
     5101 cgggccgcct ccagcggggt ggcgtacgag ctgtagtggt cgaccatgct cagccaggtg
     5161 ccgtccgcgc ggcgcatgag aggcaggggg cggccgtcga ccgtgatgtc ccaggggacg
     5221 tccgcctcgg ccgcggttcc cgtcgcggcg aggacgccct ggatgcgccg cccccggtag
     5281 gtctcgtcga aggagtccgt ggggccctcc gccaccgggc gcgagggccg ggaggcggag
     5341 acgacgggga cgatcgcgag ggccgcggcg gcgccgagca gtccgcgcag caggtcccgt
     5401 cgccgtgcgc cgtgcgccgt gcgcggtctg cccgtgacca ccggcactgc gctcacgggt
     5461 actccgtcga cgctgacgac catggtgtgc tcctcgtccg gtgcgccggc ccggttcgct
     5521 gatccggccc ggctgtccgt agcggctttc tgcggcggct ttctgcagcg ggtttctgcg
     5581 gcgcgtttct gcagcggctt tccgcagcgt ttccatgggg gtaaccgccc ggcggccctc
     5641 ctggtcaccg cccggcgccc gaacggtccg ccggggagac ggatccggac acggcgacgg
     5701 gcccggacga cggcgtccgg gcccgtggtg cgcggcgatc cgcccgccgg aggggctaga
     5761 gcccctcgtc cacaccgagg ttcgcgccgg gcaccgcctg gagcaccggg gtgatcactc
     5821 ccgcctgggg cagccggggg tccggcaggc cgtagcggtc ggggttgggc gcggtcagcg
     5881 gggcttccag ggcgagaccc gggctcagcg tgcgcaggtc ggaggcgggg gcgtcgaggc
     5941 cgaggtggtt gaagtcgctc cccaggacct ccggcagggg cgcgcgcagc cccacaccgg
     6001 gcagccccgc ggcgacgggc agctgcggaa cgacccgctc cgggatgagc cggccctcga
     6061 cgaaacgcgg gccctcgggc gcacccggcg tcggcagggg gatctcgccg ccgatcgtgg
     6121 gcagttccac gttgagggac ttctcgacgc cgtcgagcgg tacgggaacg ggcaccgtgc
     6181 cgatcgcggc ggcgggggtc acggaggcgg cggcacctgc ggcggccgcc acacacgtga
     6241 tgactgcggc gagggttcct cgggtggtcg acttcatctc gggtacgggc cctttcggag
     6301 gggttcgggg ggcgttgcgt ccgtaccggg taacgagccg gaaaacgaca tcagttcaca
     6361 attcccccgt gtgccgtaat agtgcgaatg ccatacgggg ctgaggcgag agagagccga
     6421 ggccggaggt acgacggacg gatggtcagc tcgtccagaa atcccaccac cgggtcagga
     6481 tcagcatgcc gatcaccccg atgtgcagca gcggcggcac ccaggtgaat tcgtcgagga
     6541 agttccgcac tccggccggg gccggcagga acgcgtggcg tacgtcgaac gcgacggcgt
     6601 accagaacat gaggatcgtg gcgacccagg ccagacagca ccacagacac agcgcgttga
     6661 tccggtacag ggactcgaac tgcaaccagg acacgaaccc gacgccgaag agacagccgc
     6721 cggtgaaggt cagccagtac cagcgcggga agacggcgcc ggccagcagg ctcacgccga
     6781 cgcacacgac gatcccgtag gcgaccaggc ccagcatcgg attggggaac ccgaacgccg
     6841 aggcctggtc gctcgtcatg acactgccgc aggagacgac cgggttgagg ctgcacccgg
     6901 gggtgaagcc ggggtcctcc agcagcttga acttgtcgag ggtgatgacc caggcggcca
     6961 gcagtccggc cgcaccggtg agcacgagca gcagggcgta cgcgcggccg ccgcccgcgg
     7021 gcgccgggtg cggccggggc atcagccgcg cagactgcga gcgggcagga cgatgtgcgc
     7081 cgcggccgtc agggtctcgt gggcgcccgc gaacgcggcc agctgatccg gtgtgacggc
     7141 ccggccggga acggcctccg gccaggcacg ggtggtgagg acgaggtagg cgtagccgcg
     7201 ctgctcgacg gccgcgagcc actcctgcgg cggcagacac tgggcgttga ggcccggcat
     7261 gttcaggacg gccgcaccgg actcgacgag cagggtgaac ggcaggctag gccgctcggt
     7321 gccgtcgacg acgtccccgc cgacgggcat gccgttgtcg gtgagcagac gcgcgacggc
     7381 cacggcggtc ccctcggggc cttcctcggt gtcaccgagg gagtaggcga ggaggtaggg
     7441 catgtcgctg ccgtcggggg cctcgccgct ccacggcatc acgacgaggg tgccaaggtc
     7501 ggccacgcgg aaggggcggg ttgcgctcgg ggttgaggtc accgcgcgac cctatcggcg
     7561 catcgggggg cattcgggcg tgttctcacc cgaccggggg acgccggtcc gttgctccac
     7621 acgaacgagg gacgcgccgc tcgactcgcc tcgaacagca ccgagggccg gtcccgtcgg
     7681 tgacgtgacc ggcccttgcg ggaaaggcga ctcagccccg cagcggcagc ccgccgagaa
     7741 ggccggtgtg gctgttgagg gcaccggtcg cgcccttgac ggtgctgagc acggagtcct
     7801 tgttctcggt gtcgagcgcg tccgactggt gctggaccgg catcgcgtcc tccaggttga
     7861 tgggacccct ggcgagggtg tccacggcac cgttgaggct ggtgggcgtg aggtcggcgg
     7921 gggtcgcgaa cgcgggcgcg gcggcaccgg cgaggacgat ggatccggca acgacagcgg
     7981 cagccttcag ggacttcatc ggattccttt cttcggcgac tcggcgactc ggcgactcga
     8041 ccagtcggcg aatcgggtca ccagggaaat tctgacgtcg tgcctaacga gccccgccga
     8101 gaccggaaac cgtgtgcgca gaaatttccg caccccggcg gaatgccggg gtgcggaaat
     8161 caccgggcga gcgtcagccg gcgggcaccg ccggcacggc cgcggccgga gcctcggccg
     8221 gcagggtcgg cagcgtcaga ccggcgccgg ccagcgtcgc gctgaccagg tcgagcaggc
     8281 ccgacaccac cccggtcacc gccggggcga cctggctgac gtcgagggac gtcgcggccg
     8341 cgaggagagc ggcgaccgcc ttgtccaggg cggccacggc gtcggccacc gggtcggcgg
     8401 cggccttcgc cttggcgtcg tcaccgccct tgctgagcac gggcttggcc ggcagggcgg
     8461 cggccgcgtc ggcgggcgcc gcgggcttcg ccggcagcac caccgccgag tccgcgggca
     8521 ccgcgggctt ggccggcagc acgacggccg ggtcggcggg caccgccggc ttggccggga
     8581 ccgcggcggc cgggtcggcc ggcttggccg ggacctcggc agccgggtcg gccgggacct
     8641 cgggcttcgc cgggaccgcg gcggccgggt cggccggctc cgcctcgggg tcggccgggg
     8701 tcgccggagt cgccggagtc gccggagtgg ccggggtggc cggggtggcc gccgtgatct
     8761 tggcgacggc ggccttgacg gcgtcgccga gctcggtcgc ctgttcggcg gtgagctggc
     8821 cgtcttcggc cttgaggacg gtgttgagga ggttggctac cggggtgagg acagtgccga
     8881 gctcaccgag gccctgggcc tgggcgagca gcgcgtcggt gccggcgacg ggcgtattcg
     8941 acgacgcgac cttgcgctca tgggcagcgg ctccgtcggc cgccatggcg gcggggccgg
     9001 agatgccgag gacgagggtg gcgcaaagtg cggtggaagc aatacgccgt acgggcagac
     9061 cacgcatggg aattcctttc gattgcgtcg ggtcttgtcc ccaccgtgca aacgacggtc
     9121 gccctccgca acagttcgat cgctgtgcgt gacgggcatt cgtccagctc actcgcatca
     9181 cccctggtga gagggcctgt caaggctcac cgagcgtgtc gaggcactct ccccccattc
     9241 ggggcaaggc cgtcgacggc tggccaccca cacgcgaacg gccgccctcc tggcgggagg
     9301 gcggccgttc ggcgaatgac gtgtcgtgac ctcgaaggag agggaggaga cgtcagtcgt
     9361 tgatgcaggt gttgccgaac gccgggttca gcaggccgat cacgttgacc gtgttgccgc
     9421 agacgttgac ggggatgtgc acgggaacct ggacgacatt gcccgacagc acgcccgggg
     9481 agtgctcggc gacgccgctc gcgccactgt cggcggcggc gatgccggag gcgccggcga
     9541 cggccgcggc ggcaacggag gtcaggacca ggcccttcgc gatacgcgac atggagaggt
     9601 gctccttggg gttttgacac aaacacccgg gcggggatgc ccggcgctga agtcaacgcg
     9661 cgggacccgc gggggttgtg ccgccaaacg agtgatgtca ccggagctcg acttcaccat
     9721 tccgacacac ttgtccggtt tcggtggatt aatccggaca gcggctagag ttgcgcccca
     9781 tccgacgcac gcctatagca agcaaatcgc acgaaagggc accgccggtc atgcgtaatt
     9841 ccctgggtcc gctgctacgc cgcgcaacag tcggcgttct cgccctcacc gccctctggg
     9901 cacccggcgg cgcccgggcg gccggtgcgc cgcccgccgc ggaggcggag caactcgcct
     9961 tcaaacagcg ctaccacgcc acacagcacg gcgggatcgt ccgcgcggcg aacgcggcca
    10021 tcagctgccg caccaccacc acgcccacgg gccgggcggc gcccgcctgt ccctccgcgc
    10081 gcgcgggcgg agcggccgtc aacaacgcct tcaacatgtt ctacgtcgac gtggaccgcg
    10141 acccgaacac ctacaactcc tcccgcgccg aggtccggct cccgcagggc gcgcgggtgt
    10201 cgtacgcgcg gctgtactgg ggcggcaacc tgcgcgtcgg cgagcagaag ccgcccaagg
    10261 acaacgggcg ggtgctgatc gccgagcccg gcggggagta caaggcggtg ctcgcggaca
    10321 cggtcgtggg ccaccgggtc gcccagggcg ccgacgcctt ccaggcctcc gcggacgtca
    10381 ccgggctggt gcgctcgagc ggtcagggtc tgtacacggt cgcccagatc aacgtggcca
    10441 tgggccgttc ggcggc
//
