LOCUS NZ_LMEQ01000001 10405 bp DNA linear CON 07-JUN-2024 DEFINITION Streptomyces sp. Root1310 contig_1, whole genome shotgun sequence. ACCESSION NZ_LMEQ01000001 VERSION NZ_LMEQ01000001.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. Root1310 ORGANISM Streptomyces sp. Root1310 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 2227698) AUTHORS Bai,Y., Muller,D.B., Srinivas,G., Garrido-Oter,R., Potthoff,E., Rott,M., Dombrowski,N., Munch,P.C., Spaepen,S., Remus-Emsermann,M., Huttel,B., McHardy,A.C., Vorholt,J.A. and Schulze-Lefert,P. TITLE Functional overlap of the Arabidopsis leaf and root microbiota JOURNAL Nature 528 (7582), 364-369 (2015) PUBMED 26633631 REFERENCE 2 (bases 1 to 2227698) AUTHORS Garrido-Oter,R. and Bai,Y. TITLE Direct Submission JOURNAL Submitted (08-OCT-2015) Plant-Microbe Interactions, MPIPZ, Carl-von-Linne-Weg 10, Cologne 50829, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: A5 v. 20140604 Assembly Name :: Root1310 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 300.0x Sequencing Technology :: Illumina HiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001426425.1-RS_2024_06_07 Annotation Date :: 06/07/2024 02:14:31 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 8,470 CDSs (total) :: 8,385 Genes (coding) :: 8,123 CDSs (with protein) :: 8,123 Genes (RNA) :: 85 rRNAs :: 4, 1, 1 (5S, 16S, 23S) complete rRNAs :: 4, 1, 1 (5S, 16S, 23S) tRNAs :: 76 ncRNAs :: 3 Pseudo Genes (total) :: 262 CDSs (without protein) :: 262 Pseudo Genes (ambiguous residues) :: 0 of 262 Pseudo Genes (frameshifted) :: 98 of 262 Pseudo Genes (incomplete) :: 219 of 262 Pseudo Genes (internal stop) :: 20 of 262 Pseudo Genes (multiple problems) :: 64 of 262 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 22:32:08 NOTE :: This is a single region extracted from a larger record! Orig. start :: 81923 Orig. end :: 92328 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to LMEQ01000001.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..10405 /candidate_cluster_numbers="1" /contig_edge="False" /product="ectoine" /region_number="1" /rules="ectoine_synt" /tool="antismash" cand_cluster 1..10405 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="ectoine_synt" /kind="single" /product="ectoine" /protoclusters="1" /tool="antismash" protocluster 1..10405 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[5000:5405](+)" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" /tool="antismash" proto_core 5001..5405 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" gene complement(8..871) /locus_tag="ASD48_RS00395" /old_locus_tag="ASD48_00395" CDS complement(8..871) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1091: glutamine-binding lipoprotein glnH" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130459.1" /locus_tag="ASD48_RS00395" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00395" /product="transporter substrate-binding domain-containing protein" /protein_id="WP_057599300.1" /transl_table=11 /translation="MNTLPGRRTRVLAATTVTAGLMLVAACTSTDDGGSGSKTAAGGVE LVKAGQLTTCTHLPYPPFQSEIDGKVQGFDVSLIDLAAKNLGVKQEILDTPFENFKTGA FLNSGECDLAAAGMTITDERKKNVDFSDPYFEATQAVLVDKGAGVTSLADVKSKGVKLG AQAQTTGEDYAKKQGFDPVSFESSDAVLNGLRTGQVKAVIIDFPVVQGWLKDKANADAF KVVDNLNTGEQYGFTVKKGNTKLVAAINKALADAKADGTYKKLYEKWIGPYDESAASPS AAASAS" misc_feature complement(935..949) /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 17.18" /tool="antismash" gene 1056..2156 /locus_tag="ASD48_RS00400" /old_locus_tag="ASD48_00400" CDS 1056..2156 /NRPS_PKS="Domain: Aminotran_5 (74-311). E-value: 3.6e-26. Score: 83.9. Matches aSDomain: nrpspksdomains_ASD48_RS00400_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010037833.1" /locus_tag="ASD48_RS00400" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00400" /product="aminotransferase class V-fold PLP-dependent enzyme" /protein_id="WP_057599301.1" /sec_met_domain="Aminotran_5 (E-value: 3.2e-20, bitscore: 69.3, seeds: 34, tool: rule-based-clusters)" /transl_table=11 /translation="MTHPFLDLAPLTAAHFASIEDRVARLLDTRQDVVIMQGEALLPLE GAIRGTAGPGTVALNVITGPYGQTFGDWLRDCGATVIDLAVPFHTAVTAEQIREAFAEH PGIDFVSLVHAEAATGNTNPVAAIGEVVREHGALFYLDAVASIGAEPVLPDAWGVDLCV IGAQKAMGGPAGVSAVSVSERAWARMAANPKAPRRSYLSLLDWKERWVDGGRKALLHAP AQLEMLALEACVERIEAERPETVMARHALAAAATRAGALALGGGLEPYVRDAAEAAPVA TTLRTPSGVVASELVARALASDPGLPLAAGGGALAGEMIRVNHYGGDATAGVVQGCLAA LGAALAEKGLDVDPAGARRAAEGAWR" aSDomain 1278..1988 /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS00400_Aminotran_5.1" /evalue="3.60E-26" /label="ASD48_RS00400_Aminotran_5.1" /locus_tag="ASD48_RS00400" /protein_end="311" /protein_start="74" /score="83.9" /tool="antismash" /translation="RDCGATVIDLAVPFHTAVTAEQIREAFAEHPGIDFVSLVHAEAAT GNTNPVAAIGEVVREHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVSA VSVSERAWARMAANPKAPRRSYLSLLDWKERWVDGGRKALLHAPAQLEMLALEACVERI EAERPETVMARHALAAAATRAGALALGGGLEPYVRDAAEAAPVATTLRTPSGVVASELV ARALASDPGLPLAAG" gene 2306..2833 /locus_tag="ASD48_RS00405" /old_locus_tag="ASD48_00405" CDS 2306..2833 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004002247.1" /locus_tag="ASD48_RS00405" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00405" /product="DinB family protein" /protein_id="WP_057599302.1" /transl_table=11 /translation="MTSDTPLILPDGRPVPLLTGDELPMLESWLAFHRATLELKCAGLD DEQLRQPSAAPSELTLLGLVQHLAEVERNWFQRAFAGLDVPPVFEEGTGYALEAGRDLD AALAAWRREIARGRELIAGRPLEATGRIADGPMAGLEVSLRWVLIHMIEEYARHNGHAD ILRERIDGVTGA" misc_feature complement(2973..2988) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: weak, score: 15.8" /tool="antismash" gene 3116..3622 /gene="ectA" /locus_tag="ASD48_RS00410" /old_locus_tag="ASD48_00410" CDS 3116..3622 /EC_number="2.3.1.178" /GO_function="GO:0033816 - diaminobutyrate acetyltransferase activity [Evidence IEA]" /GO_process="GO:0019491 - ectoine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="ectA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020121394.1" /locus_tag="ASD48_RS00410" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00410" /product="diaminobutyrate acetyltransferase" /protein_id="WP_057599303.1" /transl_table=11 /translation="MTAAQADLRIDSPSVEDGAALWRLAKESGTLDLNSSYSYLLWCRD FAATSAVARAENGEPVGFVTGYVRPEDPRTLLVWQVAVDAAHRGRGLAAALLDGLTARV AAERPLTAVETTITPGNTASERLFTSFADRHGATVTREVLFGAGLFPDGPHDPEVLYRI GPLAF" gene 3684..4955 /gene="ectB" /locus_tag="ASD48_RS00415" /old_locus_tag="ASD48_00415" CDS 3684..4955 /EC_number="2.6.1.76" /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate transaminase activity [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 2e-73. Score: 239.3. Matches aSDomain: nrpspksdomains_ASD48_RS00415_Aminotran_3.1" /codon_start=1 /gene="ectB" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1013: aminotransferase class-III" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007381147.1" /locus_tag="ASD48_RS00415" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00415" /product="diaminobutyrate--2-oxoglutarate transaminase" /protein_id="WP_057599304.1" /sec_met_domain="Aminotran_3 (E-value: 4.2e-79, bitscore: 262.9, seeds: 13, tool: rule-based-clusters)" /transl_table=11 /translation="MTITQPDLSVFETLESEVRSYCRSWPAVFDRAQGSRMYDEDGHRY LDFFAGAGSLNYGHNNPVLKRALIDYLMRDGVTHGLDMSTVAKRTFLQTFQDLVLRPRD LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA GVPLVHGTPMPFDNYFEGQVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP EWLRALKDLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPMS LCLFKPELDVWEPGEHNGTFRGNNPAFVTATAALETYWADGSAMEKQTRTRGEQIEQGL ISITEENLADVKEYRGRGLVWGLEFHEKARAGRVAKRAFELGLLIETSGPESEVVKLLP ALTITPEELDEGLSVIARAVRETV" aSDomain 3768..4781 /aSDomain="Aminotran_3" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS00415_Aminotran_3.1" /evalue="2.00E-73" /label="ASD48_RS00415_Aminotran_3.1" /locus_tag="ASD48_RS00415" /protein_end="366" /protein_start="28" /score="239.3" /tool="antismash" /translation="FDRAQGSRMYDEDGHRYLDFFAGAGSLNYGHNNPVLKRALIDYLM RDGVTHGLDMSTVAKRTFLQTFQDLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGVPLVHGTPMPFDNYFEGQVPDFLWFER LLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALKDLCERQDMLLIVDDIQMGCGR TGAFFSFEEAGIVPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFV TATAALETYWADGSAMEKQTRTRGEQIEQGLISITEENLADVKEYRGRGLVWGLEFH" gene 5001..5405 /locus_tag="ASD48_RS00420" /old_locus_tag="ASD48_00420" CDS 5001..5405 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) ectoine: ectoine_synt" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009337952.1" /locus_tag="ASD48_RS00420" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00420" /product="ectoine synthase" /protein_id="WP_057599305.1" /sec_met_domain="ectoine_synt (E-value: 5.4e-54, bitscore: 178.3, seeds: 10, tool: rule-based-clusters)" /transl_table=11 /translation="MIVRSFKDIEGTDRHVRAASGTWESKRIVLAQERVGFSLHETILY AGTETSMWYANHIEAVVCVEGAAELTDHETGRTHSITPGTMYLLDGHERHTLRVKEDFR CICVFNPPVTGREDHDENGVYPLLTEPEEV" misc_feature complement(5410..5425) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 16.26" /tool="antismash" gene 5411..6298 /gene="thpD" /locus_tag="ASD48_RS00425" /old_locus_tag="ASD48_00425" CDS 5411..6298 /EC_number="1.14.11.55" /codon_start=1 /gene="thpD" /gene_functions="biosynthetic-additional (rule-based-clusters) PhyH" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016436210.1" /locus_tag="ASD48_RS00425" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00425" /product="ectoine hydroxylase" /protein_id="WP_057599306.1" /sec_met_domain="PhyH (E-value: 3.2e-38, bitscore: 129.0, seeds: 39, tool: rule-based-clusters)" /transl_table=11 /translation="MTTLTDLYPTRGTTEVSVPRKDPVVWGSPDAPGPIPAAGLQEYER DGFLAVDRLISDDEVTVCRRELERLVADPEIRADGRSIVEPKSKEIRSVFEVHKLSPVF AALVRDERVVGRARQILGSDVYVHQSRINVKPGFGAGGFYWHSDFETWHAEDGLPNMRT VSVSIALTENLDTNGGLMIMPGSHRTFLGCAGATPEDNYKKSLQMQDAGTPSDEALTAM AGDYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFAAPVR RPEYIGARDFTPVR" gene complement(6418..7470) /locus_tag="ASD48_RS00430" /old_locus_tag="ASD48_00430" CDS complement(6418..7470) /NRPS_PKS="Domain: Aminotran_5 (17-344). E-value: 2.3e-22. Score: 71.3. Matches aSDomain: nrpspksdomains_ASD48_RS00430_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130466.1" /locus_tag="ASD48_RS00430" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00430" /product="aminotransferase class V-fold PLP-dependent enzyme" /protein_id="WP_057599307.1" /sec_met_domain="Aminotran_5 (E-value: 2.9e-17, bitscore: 59.5, seeds: 34, tool: rule-based-clusters)" /transl_table=11 /translation="METFESLVRAEFTPKTTYLNTASNGLLPARTVAALHEAAVLRAEG RPLTPLHEDVEACRAAYARLAGVPVTRVALGASVAAHTGVIAASLPAGAEVLTAEDDFT SVLNPFHVRGDLKVRAVPLERIAESVRPGTALVAVSAAQSADGRIADLPALREAARTHG ARTYVDFSQSAGWLATDADAHDFSAAVSFKWLLGPHGAAFLVVPEDFGGLSPVLAGWVA GERPWDSCYGPVAELARSARRFDLTHALFTYAGLRRSLELVEELGVAAIGAHDLALADR FRAGLAGLGHRPVAAPGSAIVSVPGLGFRQPELAAAGIQVSDRSGHLRASFHLFNTPAD VDRLLDALAA" aSDomain complement(6439..7419) /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ASD48_RS00430_Aminotran_5.1" /evalue="2.30E-22" /label="ASD48_RS00430_Aminotran_5.1" /locus_tag="ASD48_RS00430" /protein_end="344" /protein_start="17" /score="71.3" /tool="antismash" /translation="YLNTASNGLLPARTVAALHEAAVLRAEGRPLTPLHEDVEACRAAY ARLAGVPVTRVALGASVAAHTGVIAASLPAGAEVLTAEDDFTSVLNPFHVRGDLKVRAV PLERIAESVRPGTALVAVSAAQSADGRIADLPALREAARTHGARTYVDFSQSAGWLATD ADAHDFSAAVSFKWLLGPHGAAFLVVPEDFGGLSPVLAGWVAGERPWDSCYGPVAELAR SARRFDLTHALFTYAGLRRSLELVEELGVAAIGAHDLALADRFRAGLAGLGHRPVAAPG SAIVSVPGLGFRQPELAAAGIQVSDRSGHLRASFHLFNTPADVDRL" misc_feature complement(7507..7523) /note="TFBS match to GnfM, Regulator of nitrogen-fixation genes, confidence: weak, score: 19.76" /tool="antismash" gene complement(7567..8283) /locus_tag="ASD48_RS00435" /old_locus_tag="ASD48_00435" CDS complement(7567..8283) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130467.1" /locus_tag="ASD48_RS00435" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00435" /product="DsbA family oxidoreductase" /protein_id="WP_057599308.1" /transl_table=11 /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDQVEVVHRSFELDP GRAKGDVQPVLAMLTKKYGMSEAQAQSGEENLGAQAAAEGLDYRTRDRDHGNTFDMHRL LHFAKEHGRQDELIQLLYRANFAEERSVFSEGDERLVELAAEAGLDAEAARAVLADPAR YADEVRADEREAAQLGANGVPFFVLDRAYGVSGAQPAEVFSQALTQAWGDRSPLKLIDD GGAQACGPDGCAVPQQ" misc_feature complement(8363..8376) /note="TFBS match to ArgR, Regulator of arginine biosynthesis genes, confidence: weak, score: 17.0" /tool="antismash" gene complement(8444..8959) /locus_tag="ASD48_RS00440" /old_locus_tag="ASD48_00440" CDS complement(8444..8959) /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130468.1" /locus_tag="ASD48_RS00440" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00440" /product="GNAT family N-acetyltransferase" /protein_id="WP_199875602.1" /transl_table=11 /translation="MIEERVRGNRVIRTAVPAEAERVAALHARARATYYPDGVPQDGTD WLAAWRAAIERPDGHVLCVVEQGRLVGLASFRTPEGAPAHTVKLFQFHVDPDHWRSGIG TDLHTACVEQWRADGRRTAVLDVHVDNRRAQAFYARQGWSPDPENPPGEGEHHLWLRYA VTRERPGE" gene complement(9051..9659) /locus_tag="ASD48_RS00445" /old_locus_tag="ASD48_00445" CDS complement(9051..9659) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016436202.1" /locus_tag="ASD48_RS00445" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="ASD48_00445" /product="DUF1349 domain-containing protein" /protein_id="WP_057599309.1" /transl_table=11 /translation="MDVSLPELPFPLRTYGPDGHWSHENGVLTGWAGARQDRFVPPTGD GVESAADAPRLLGAPEGDFQLIARVTVGFNWAFDAGVLYVHVGERAWAKLCLEYSPDVA TVCTVVTRGHSDDANSFTVEGSSVWLRVSRTGRAFAFHASRDGKRWTFVRLFTLGEEKE TGAALVGFMTQSPMGEGCVVTYDHLEFRTEWPDDLRDGS" ORIGIN 1 catggggtca ggaggccgag gcggcggcgg acggggacgc ggccgactcg tcgtacggcc 61 cgatccactt ctcgtacagc ttcttgtagg tgccgtcggc cttcgcgtcc gccagcgcct 121 tgttgatcgc ggcgaccagc ttggtgttgc ccttcttcac cgtgaagccg tactgctcac 181 cggtgttgag gttgtcgacg accttgaagg cgtcggcgtt ggccttgtcc ttcagccagc 241 cctggacgac cgggaagtcg atgatgacgg ccttgacctg gccggtgcgc agaccgttga 301 ggacggcgtc ggaggactcg aaggagaccg ggtcgaagcc ctgcttcttg gcgtagtcct 361 cgccggtggt ctgcgcctgg gcgccgagct tgacgccctt ggacttcacg tcggcgagcg 421 aggtgacacc cgcgcccttg tcgaccagga cggcctgggt ggcctcgaag tacgggtcgg 481 agaagtcgac gttcttcttg cgctcgtcgg tgatggtcat gccggccgcg gccagatcgc 541 actcgccgga gttcaggaag gcgccggtct tgaagttctc gaacggcgtg tcgaggatct 601 cctgcttcac gcccaggttc ttggcggcca ggtcgatcag ggacacgtcg aagccctgca 661 ccttgccgtc gatctccgac tggaagggcg ggtagggcag gtgggtgcag gtggtgagct 721 ggcccgcctt gacgagctcg accccgccgg cggcggtctt ggagccgctg ccgccgtcat 781 cggtggaggt gcaggcggcg acgagcatca gcccggccgt cacggtggtg gcggccagga 841 cgcgggtccg gcggccgggg agggtgttca cggcgggcct tcctgtaagg gaactgtggg 901 ttccgattat aaggagatgt ttgaggctct caaatcaaac cgatggtcac cgggccgcgc 961 gacctgcgaa gtgaccggtg gggagggcgg gaggggtggg ggggcgtgcc ggttagtctc 1021 gtcacctcta cccagtgagt gaagagagca ccgccgtgac acacccgttc ctggatcttg 1081 ccccgctgac cgccgcacat ttcgcctcga tcgaggaccg cgtggcgcgg ctgctggaca 1141 cccggcagga cgtcgtgatc atgcagggcg aggcgctgct gccgctggag ggcgcgatcc 1201 gcggcacggc cggtccgggc acggtcgcac tgaacgtgat caccggtccg tacgggcaga 1261 ccttcgggga ctggctgcgg gactgcggcg ccacggtgat cgatctggcc gtgcccttcc 1321 acacggcggt gacggccgag cagatccggg aggcgttcgc ggagcacccc gggatcgact 1381 tcgtgtcgct ggtgcacgcg gaggcggcga ccggcaacac caacccggtc gcggcgatcg 1441 gcgaggtggt gcgggagcac ggcgcgctgt tctacctgga cgcggtcgcc tcgatcggcg 1501 ccgagccggt gctgccggac gcgtggggcg tggacctgtg cgtgatcggc gcgcagaagg 1561 cgatgggcgg cccggcgggc gtgtcggcgg tgtcggtgag cgagcgggcg tgggcgcgga 1621 tggccgcgaa cccgaaggcg ccgcgccggt cgtacctgtc cctgctggac tggaaggagc 1681 gctgggtcga cggcggtcgc aaggcgctgc tgcacgcgcc ggcgcagctg gagatgctgg 1741 cgctggaggc gtgtgtcgag cggatcgagg cggagcggcc ggagacggtg atggcccggc 1801 acgcgttggc cgccgccgcg acgcgcgcgg gcgcgctcgc gctgggcggc gggctggagc 1861 cgtacgtgcg cgacgcggcg gaggcggcgc ccgtcgccac gacgctgcgg acgccgtcgg 1921 gggtggtggc gtcggagctg gtggcgcggg cgctggcgag cgaccccggg ctgccgctgg 1981 ccgcgggcgg gggcgcgctg gccggggaga tgatccgggt caaccactat gggggcgacg 2041 cgaccgccgg cgtggtgcag ggatgcctgg cggcgctggg tgccgcgctg gcggagaagg 2101 ggctggacgt cgatccggca ggggcccggc gggccgcgga gggcgcctgg cggtaggcgc 2161 cgccgggccg gatcaccggc cgtcggatca ccgtcggccg gaccggcgtc ggccggaccg 2221 gcgtcggccg gaccggcgtc ggccggaccg gcgtcggccg gaccggcgac atcccgctgt 2281 cggtgccgcc tgccatgctg cccccatgac ctccgacact cccctcatcc tccccgacgg 2341 ccggcccgtc cccctgctga ccggtgacga actccccatg ctggagagct ggttggcatt 2401 ccaccgggcc acgctcgagc tgaagtgcgc ggggctggac gacgagcagc tgcggcaacc 2461 ctcggcagcg ccctccgagt tgaccctgct cggtctcgtc cagcatctcg cggaggtgga 2521 acgcaactgg ttccagcggg cgttcgccgg gctggacgtg ccgcccgtct tcgaggaggg 2581 gaccgggtac gccctcgagg ccgggcggga cctcgacgcg gcgctggccg cctggcggcg 2641 ggagatcgcg cgcggacgtg agctgatcgc cgggcggccg ctcgaggcca ccgggcggat 2701 cgccgacggg ccgatggccg ggctcgaggt cagcctgcgc tgggtgctca tccacatgat 2761 cgaggagtac gcccggcaca acggccacgc ggacattctc cgggagcgta tcgacggggt 2821 taccggagcc tgaattcaag gtaattcacg aattcccgtc ggcccctttc ccgtcccctt 2881 ctcgctcccc tttctcgacg ataggtttcc tgagttcttc tgccccgatt ccccgcacct 2941 aaacgcgggg aatttcaggc aggtttcgag tgcgtgacgc attgcacaag cgaggcgata 3001 tgcccttttc gcgcggtgca aaagcggacg aaacgtccat ctgtcccggc ggcatcacgg 3061 aatcaccacg gcctctccat gcgttattga atttccctgg gtaagttcaa tccgcatgac 3121 tgccgcacaa gcagacctac gtatcgacag cccgtcggtg gaagacggcg cagcgctctg 3181 gcgtctcgcg aaggaatccg gaaccctcga cctgaactcg tcctacagct atctgctgtg 3241 gtgtcgcgac ttcgccgcca cctcggcggt ggcccgcgcg gagaacggcg agccggtcgg 3301 gttcgtcacc gggtacgtcc ggccggagga cccgcggacc ctgctggtct ggcaggtggc 3361 cgtcgacgcc gcgcaccgtg gtcgcggcct cgccgccgcc ctgctggacg ggctgaccgc 3421 acgggtcgcc gccgaacgcc cgctcacggc cgtggagacc acgatcacgc cgggcaacac 3481 cgcctccgag cggctgttca cctcgttcgc cgaccggcac ggggcgaccg tcacccgtga 3541 ggtgctgttc ggcgccggtc tgttccccga cggcccgcac gaccccgagg tcctgtaccg 3601 gatcggcccc ctcgccttct gacccgcgcg ccccgcgtcc gcccgcctct ccttccgacc 3661 cccactccga ggagcgtttc gtcgtgacca tcacccagcc cgacctcagc gtgttcgaga 3721 ccctcgagtc cgaggtgcgc agctactgcc gcagctggcc cgccgtcttc gaccgcgcgc 3781 agggcagccg gatgtacgac gaggacggtc accgctacct ggacttcttc gccggtgccg 3841 gatccctcaa ctacggccac aacaaccctg tgctgaaacg ggcgttgatc gactacctga 3901 tgcgggacgg cgtcacgcac gggctcgaca tgtcgaccgt ggccaagcgg accttcctgc 3961 agaccttcca ggatctggtg ctgcggccgc gtgacctgcc ctacaaggtc atgttcccgg 4021 gcccgaccgg caccaacgcc gtggagtcgg ccctgaagct ggcgcggaag gtgaagggac 4081 gcgaggccat cgtctcgttc accaacgcct tccacgggat gtccctcggg tcgctcgccg 4141 tgaccggcaa cgccttcaag cgggccggtg ccggggtacc gctggtgcac ggtacgccca 4201 tgccgttcga caactacttc gagggccagg tacccgactt cctctggttc gagcggctgc 4261 tcgaggacca gggatccggg ctcaacaagc cggccgccgt gatcgtcgag accgtgcagg 4321 gcgagggcgg catcaacgtc gcgcgtccgg agtggctgcg ggcgctcaag gacctgtgcg 4381 aacgccagga catgctgctg atcgtcgacg acatccagat gggatgcggg cgcaccgggg 4441 ccttcttctc cttcgaggag gccgggatcg tccccgacat cgtgaccgtc tccaagtcga 4501 tcagcggcta cggactgccc atgtcgctct gcctgttcaa gcccgagctg gacgtgtggg 4561 agccgggtga gcacaacggc accttccgcg gcaacaaccc ggccttcgtc accgccaccg 4621 ccgccctgga gacgtactgg gccgacgggt ccgcgatgga gaagcagacc cggacgcggg 4681 gcgaacagat cgagcagggg ctcatctcga tcaccgagga gaacctcgcc gacgtcaagg 4741 agtaccgggg ccgcggcctg gtgtggggcc tggagttcca cgagaaggcg cgggccgggc 4801 gggtcgcgaa gcgggccttc gagctcgggc tgctgatcga gacgtccggt ccggagagcg 4861 aggtcgtcaa actgctgccg gccctgacca tcacccccga ggaactggac gagggcctca 4921 gtgtcatcgc ccgcgccgta cgggagaccg tctgacgtcc tcggaccccg tatcccctac 4981 ctaggaggca tcgcaccacc gtgatcgtcc gttcgttcaa ggacatcgaa ggcaccgacc 5041 ggcatgtgcg ggcggcgtcc ggcacctggg agagcaagcg catcgtgctc gctcaggaac 5101 gggtcgggtt ctcgctgcac gaaacgattc tgtacgcggg taccgagacg tcgatgtggt 5161 acgcgaacca catcgaggcc gtcgtctgcg tcgagggcgc ggccgaactg accgaccacg 5221 agaccgggcg gacgcacagc atcacgcccg gcaccatgta cctcctcgac gggcacgagc 5281 ggcacacgct gcgcgtcaag gaggacttcc gctgcatctg cgtgttcaac ccgcccgtca 5341 cggggcggga ggaccacgac gagaacggcg tgtaccccct gctgaccgag cccgaggagg 5401 tgtaagcatc gtgaccaccc tcaccgatct ctaccccacc cgtggcacca ccgaggtgtc 5461 cgtaccccgc aaggaccccg tcgtctgggg ctcccccgac gcgccgggcc ccatcccggc 5521 ggccggcctc caggagtacg agcgcgacgg cttcctcgcc gtcgaccggt tgatcagcga 5581 cgacgaggtc accgtctgcc gacgggagct ggagcggctg gtcgccgacc cggagatccg 5641 ggccgacggg cgctcgatcg tcgagccgaa gtccaaggag atccgctccg tcttcgaggt 5701 gcacaagctc agtcccgtgt tcgccgcgct cgtccgcgac gagcgggtcg tggggcgcgc 5761 ccggcagatc ctgggctcgg acgtgtacgt gcaccagtcg cggatcaacg tcaagccggg 5821 cttcggggcc gggggcttct actggcactc cgacttcgag acctggcacg ccgaggacgg 5881 tctgccgaac atgcggacgg tgtccgtgtc gatcgcgctg accgagaacc tcgacaccaa 5941 cggcgggctc atgatcatgc cgggctcgca ccggacgttc ctcggctgcg ccggggcgac 6001 gcccgaggac aactacaaga agtcgctcca gatgcaggac gcgggcaccc cctcggacga 6061 ggcgctgacc gcgatggccg gcgactacgg catcaagttg ttcacgggca aggccggttc 6121 ggcgacctgg ttcgactgca actgcatgca cgggtccggc gacaacatca cgccgttccc 6181 gcgcagcaac gtgttcatcg tgttcaacag cgtggagaac acggccgtgg agccgttcgc 6241 ggcaccggtc cgccggccgg agtacatcgg cgcgcgggac ttcacgccgg tgcgctgaac 6301 cggttcccgc aggctgcgcc ggcaggcccg gacgccccca cccggatcgg gtggcggcgt 6361 ccgggcctgc cgtgcgtcgg ggccgccgtg cttccgggcc tgccgcgcgt cggatcctca 6421 ggccgcgagg gcgtcgagca gccggtcgac gtccgcgggc gtgttgaaca ggtggaagga 6481 agcgcgcaga tggcccgagc gatcggagac ctggatcccg gcggcggcca gctcgggctg 6541 acggaagccg agtccgggca ccgagacgat cgcggagccg ggcgccgcga cgggccggtg 6601 gcccagcccg gcgagtcccg cgcggaagcg gtcggccagg gcgaggtcgt gggcgccgat 6661 cgccgccacg ccgagttcct ccaccagttc gagggaacgg cgcagtccgg cgtaggtgaa 6721 cagggcgtgc gtcaggtcga accgccgggc cgagcgggcg agttcggcca ccggtccgta 6781 gcagctgtcc cagggccgct cgccggccac ccatccggcg aggaccggtg acagcccgcc 6841 gaagtcctcc ggtaccacca ggaaggccgc accgtgcggg ccgagcagcc acttgaagga 6901 gacggcggcg gagaagtcat gggcgtcggc gtccgtcgca agccagccgg ccgactgcga 6961 gaagtcgacg taggtacggg cgccgtgcgt cctggccgcc tcgcgcaggg cggggaggtc 7021 ggcgatccgg ccgtcggcgg actgggcggc gctcaccgcg accagtgccg tgccggggcg 7081 gacggactcg gcgatccgct ccagcgggac ggcgcggacc ttgaggtccc cgcggacgtg 7141 gaacgggttg agtacggagg tgaagtcgtc ctcggcggtg agcacttccg cgcccgcggg 7201 gagcgaggcg gcgatcacgc cggtgtgcgc ggcgaccgag gcgcccagcg ccacccgggt 7261 gaccgggacg ccggccagcc gggcgtacgc ggcccggcag gcctccacgt cctcgtgcag 7321 cggggtgagc ggcctgccct cggcgcgcag caccgccgcc tcgtgcaggg cggcgacggt 7381 acgggccggc agcaggccgt tgctcgccgt gttcaggtac gtggtcttcg gggtgaactc 7441 ggcgcggacg aggctctcga aggtctccat gcgtccactg tgggaccccg ggaccccctc 7501 gtccattgcc gatttttacg tgattccact aaggagagct tatagatcgg ctctcacctg 7561 cgggtttcac tgctgcggga ccgcgcaccc gtccgggccg caggcctgtg cgccgccgtc 7621 gtcgatcagc ttcagcgggg aacggtcgcc ccaggcctgc gtgagggcct ggctgaagac 7681 ctctgcgggc tgggccccgg agacaccgta ggcgcggtcg aggacgaaga agggcacgcc 7741 gttcgccccg agctgagcgg cctcgcgctc gtcggcgcgg acctcgtcgg cgtagcgggc 7801 cgggtcggcg aggaccgcgc gggcggcctc ggcgtccaga ccggcctcgg cggccagttc 7861 cacgagccgc tcgtcgccct cggagaagac ggaccgctcc tcggcgaagt tcgcccggta 7921 gaggagctgg atcagctcgt cctgccggcc gtgttccttg gcgaagtgca gcaggcggtg 7981 catgtcgaag gtgttgccgt ggtcgcggtc ccgggtgcgg tagtcgaggc cctcggcggc 8041 ggcctgggcg cccaggttct cctcgccgga ctgcgcctgc gcctcgctca tcccgtactt 8101 cttggtgagc atggccagta cgggctggac gtcgcccttc gcgcggcccg ggtccagctc 8161 gaaggagcgg tgcaccacct cgacctggtc acggtgcggg aaggccgcga gcgccttctc 8221 gaagcgggcc ttgcccacgt agcaccaggg gcaggcgatg tcgctccaga tctcgacgcg 8281 catgtctcgg ctctctccag gtcgtgcggc tgggtacgga gctcccccgc gggagatccg 8341 cacggaggtt ccctccggcg agtgcatgaa cgttcaagca ggacgtttca ttccccggcc 8401 gctccccggg ctgctcgcgg tcactccccc cgccgctccc cggtcactcc cccggccgct 8461 ccctggtcac ggcgtacctc agccagaggt ggtgctcgcc ctcgccgggc gggttctccg 8521 ggtccgggct ccagccctgc cgggcgtaga acgcctgggc ccgccggttg tcgacgtgca 8581 cgtcgagcac ggccgtgcgc cgcccgtccg cgcgccactg ctcgacgcag gccgtgtgca 8641 ggtccgtacc gatccccgaa cgccagtggt cggggtcgac gtggaactgg aacagcttga 8701 ccgtgtgcgc gggcgcgccc tccggcgtgc ggaaggaggc cagaccgacg agccgcccct 8761 gctcgacgac gcacagcaca tggccgtcgg gccgctcgat ggccgcgcgc caggcggcga 8821 gccagtcggt gccgtcctgc gggaccccgt cggggtagta cgtggcccgg gcgcgcgcgt 8881 gcagcgcggc gaccctctcc gcctcggcgg gaacggcggt gcggatcacc cggtttcccc 8941 tgacacgttc ttcgatcatg caggtgagga cgaaagggct ctcgcgccgg ttccggccgg 9001 ctagtgctgc gaccggaaag gttcaccggc tcgcgacgcc cggcacggca ctagcttccg 9061 tcccgcaggt cgtccggcca ctcggtcctg aactcgagat ggtcgtaggt cacgacgcac 9121 ccctcgccca tcggtgactg cgtcatgaag ccgaccaggg ccgcgccggt ctccttctcc 9181 tcgcccagtg tgaacaggcg gacgaaggtc cacctcttgc cgtcccggga ggcgtggaag 9241 gcgaaggcac ggccggtcct gctcacccgg agccagaccg aactgccctc cacggtgaag 9301 gagttggcgt cgtcggagtg tcctcgggtg accaccgtgc agacggtggc cacgtccggg 9361 gagtactcca ggcacagctt ggcccaggcc cgctcaccga cgtggacgta caacacgccc 9421 gcgtcgaagg cccagttgaa tccgacggtc acgcgggcga tgagctggaa gtcaccctcc 9481 ggcgccccca gcagccgggg cgcgtcggcg gcggattcca ccccgtcgcc ggtgggcggc 9541 acgaaccggt cctgccgggc cccggcccac ccggtgagca ccccgttctc gtgggaccag 9601 tgcccgtcgg gcccgtaagt acgcagggga aagggcagtt cgggaagcga gacgtccatg 9661 acctcatcat ctcagggagc ggagaaaccg agaggcgcgg gggacgggcg cgacaagcca 9721 ccggaaggct gcgcccgatg atccaccgcg cacggtccac cgcgccactc gacgccgccc 9781 gcgcggagcg ctaccgctcc agacgcccgt tgaaccggcg aggcagcccc agctcgttct 9841 cgtcccgcag ctccacgggc agcagcgccg cgggagcgtt ctggtaggcg accggccgca 9901 gccaccgctc gatggcggtc ccgccgaccg aggtggacgt ggaggtggtg gccgggtacg 9961 ggccgccgtg atgctgggcc ggcgcgacgg cgacgcccgt gggccagccg ttcaccagca 10021 cgcgcccggc cagcggggtc agctccgcga ggatctcgcc gcccctgccc tcgcccgcgg 10081 cctctccctc ggacagctgg acggtcgccg tgaggtttcc gggcaggcgc gacagcaccg 10141 ccttgacctc gccctcgtcg tcgtagcgga ccacgacggt gaccggcccg aagcactctt 10201 cgagcagcag gtcgtgcgcg ccctcggcgg ccagccggga ggccggcacg gtcaggaagc 10261 ccgcgctgac ggtgtgctcc ccgccggcgc cgggcgtcac cggcgactcc acgtcgggca 10321 gctcggcccg ctcggcgacc ccggcgatga agttgtcgcg catccggtgg tccagcagca 10381 cgcccgcgtc ggtgtcgctc accgc //