LOCUS       NZ_CP013023            26344 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Paenibacillus bovis strain BD3526 chromosome, complete genome.
ACCESSION   NZ_CP013023
VERSION     NZ_CP013023.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus bovis
  ORGANISM  Paenibacillus bovis
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5354277)
  AUTHORS   Gao,C., Han,J., Liu,Z., Xu,X., Hang,F. and Wu,Z.
  TITLE     Paenibacillus bovis sp. nov., isolated from raw yak (Bos grunniens)
            milk
  JOURNAL   Int J Syst Evol Microbiol 66 (3), 1413-1418 (2016)
   PUBMED   26769366
REFERENCE   2  (bases 1 to 5354277)
  AUTHORS   Wu,Z., Gao,C., Liu,Z. and Zheng,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2015) Starter Culture Research Department, State
            Key Laboratory of Dairy Biotechnology, Bldg 2, No. 1518, West
            Jiangchang Road, Shanghai 200436, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP3 v. Sep-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 136.0x
            Sequencing Technology             :: PacBio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:10:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,833
            CDSs (total)                      :: 4,715
            Genes (coding)                    :: 4,671
            CDSs (with protein)               :: 4,671
            Genes (RNA)                       :: 118
            rRNAs                             :: 10, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 21 of 44
            Pseudo Genes (incomplete)         :: 22 of 44
            Pseudo Genes (internal stop)      :: 3 of 44
            Pseudo Genes (multiple problems)  :: 2 of 44
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:49:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 488820
            Orig. end                         :: 515164
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP013023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26344
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26344
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26344
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16344](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16344)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(277..1338)
                     /locus_tag="AR543_RS02090"
                     /old_locus_tag="AR543_02080"
     CDS             complement(277..1338)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013918594.1"
                     /locus_tag="AR543_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02080"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_060531412.1"
                     /transl_table=11
                     /translation="MEIGISTFVETTPDTETGKTISHAERIRQVVDEIVLADKVGLDIF
                     GVGEHHRVDYAASAPAVILAAAASQTERIRLTSAVTVLSSADPVRVFQEFATLDAISNG
                     RAEIMAGRGSFIESFPLFGYDLDDYDALFDEKLELLLKIRDSEKVTWEGGHRPAINNRG
                     IYPRPVQEPLPVWIGSGGNTESVVRAGLLGLPLVLAIIGGRPVQFAPLVELYYKAAAHA
                     GHDASKLSVASHSHGFIADTTEMAADKFFPSTQASMNVLGRERGWGPYTRASFDAARSL
                     EGALYVGDPETVATKIINLRKQVGITRFMLHTPVGTMSNHDDVLRAVELLGTEVAPRVR
                     EEVARWEAENSEQ"
     misc_feature    1462..1478
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.88"
                     /tool="antismash"
     misc_feature    1703..1717
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.1"
                     /tool="antismash"
     misc_feature    complement(1704..1717)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.94"
                     /tool="antismash"
     misc_feature    complement(1705..1718)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.12"
                     /tool="antismash"
     misc_feature    1757..1775
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 22.44"
                     /tool="antismash"
     gene            complement(1864..2205)
                     /locus_tag="AR543_RS02095"
                     /old_locus_tag="AR543_02085"
     CDS             complement(1864..2205)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822535.1"
                     /locus_tag="AR543_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02085"
                     /product="zinc ribbon domain-containing protein YjdM"
                     /protein_id="WP_017813347.1"
                     /transl_table=11
                     /translation="MTDLPNCPECNSAYTYEDGNLLICPECAHEWTPGEDVDSTEDALV
                     VRDANGNILQDGDAVTVIKDLKVKGSSSVLKIGTRVKSIRLVDGDHNIDCKIDGFGAMK
                     LKSEFVKKN"
     misc_feature    complement(2385..2405)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.01"
                     /tool="antismash"
     gene            2428..3366
                     /locus_tag="AR543_RS02100"
                     /old_locus_tag="AR543_02090"
     CDS             2428..3366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017813346.1"
                     /locus_tag="AR543_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02090"
                     /product="prenyltransferase"
                     /protein_id="WP_227871816.1"
                     /transl_table=11
                     /translation="MLSDSILRAFTLKNSLKLLRPAAVLCSSVAIIFSGVFPLAAYYEL
                     SVSSLVITALLLLIGCILIHGVLTHALNDYADYLSGTDQLSPAMLSGGSRVIQEGRISP
                     AALHRFGIGLTIVLIAATAIIALFGHYALAALLLIGIWGAVSYSLPPLRFSYAPLAGEW
                     LSTFPSTFFLGLGGAWLMLGTFPQWAVQNALINALYCVAWVMVHHIPDLDADRQASPVK
                     RTSVVWAADRWGIGYSRLPALVYLGLIALCVVWLLGTGRLWGAAGIAVMVALSVYWICR
                     MDVRDPEQVTNCEKKLLLLAVGGAVWLGIFI"
     gene            complement(3671..4609)
                     /locus_tag="AR543_RS02105"
                     /old_locus_tag="AR543_02095"
     CDS             complement(3671..4609)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="AR543_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02095"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_060531416.1"
                     /transl_table=11
                     /translation="MTDILLVIVSVVGVALAIYIGVIHRQLQQMVQMLDRLQRDPQPAY
                     LHIRSRISVINRLAGQLNLLRDRIYLFHNQAMQLEKTQRQVMTHIAHDLRTPLTSLSGY
                     AEMLKNPKVIQDPELSGKYRDIIFDKARALTQLLGNFFEWTRLESGDIQIHFQQVNLTA
                     KIEECIVQVIDQFEKWGIPPELELPAAPVLVQADPVSVERILSNLISNTIRYGHGGEGR
                     HGIRLWAERNQAWVEVWDTGEGIPADELPLLFDRLYQASASRHSPAGSGLGLAITKKLV
                     EKQHGQIRVESTPYVRTSFKFCLERDLGKEE"
     gene            complement(4609..5337)
                     /locus_tag="AR543_RS02110"
                     /old_locus_tag="AR543_02100"
     CDS             complement(4609..5337)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010494238.1"
                     /locus_tag="AR543_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02100"
                     /product="response regulator transcription factor"
                     /protein_id="WP_227871817.1"
                     /transl_table=11
                     /translation="MNRSMTLARIMIVEDDIEICDLIAQTLIGENYGVIQIHNGLEAIR
                     EFEAADYDLVILDIMLPGLDGLEVLRRIREKKKIPVLLLSAKDAEIDKIAGLAGGADDY
                     LTKPFLLGELLARVKAQLRRYFYYSESEQPAHKVWKYKELELDGSTYQVRIRGEHRTLT
                     AKEFAILQLLMSQPQRVFTKSQIFESVWEEPYSSDVDENTVMVHIRRLRTKIEDKASSP
                     VYVQTVWGIGYRLGGNEEEE"
     gene            complement(5334..6047)
                     /locus_tag="AR543_RS02115"
                     /old_locus_tag="AR543_02105"
     CDS             complement(5334..6047)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="AR543_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02105"
                     /product="ABC transporter permease"
                     /protein_id="WP_060531418.1"
                     /transl_table=11
                     /translation="MLTLIFRELLLFRRSVVLRLMILLLVLQLLITLLKADSGSWQHLM
                     DQTYMNLWFRPTFFTFLAGYLFTRDRDRGLLSLHKTYPFHWGEWYTAKILTSLLLMGLL
                     LFGSELITLLIGLWALDVSVSAAALGKWFIKDLVVSWIIYAGFSAYGAVLALISRTSLY
                     LTIVLLGQFLLGLVLIIRVPDWIIYYPWLVPSIYLHGTGKGTWPDQAYPLVIYAVLGAI
                     CLVWGGWMYRRLQRR"
     gene            complement(6047..6967)
                     /locus_tag="AR543_RS02120"
                     /old_locus_tag="AR543_02110"
     CDS             complement(6047..6967)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="AR543_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02110"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_060531421.1"
                     /transl_table=11
                     /translation="MVDHPDRLIHADHLCLSAGDSGVRVERLNMDVQRGAFYVILGEKG
                     SGKRTLLRGLAGDLVPLSGKLEWFGSINIHSDYVWKNRIGVMCEPLSFVPNLTVYEHLE
                     LHRRMMGVPDKQASHTMLELLSLEKYAHQRAGRIPAEAARGCAIARALLHRPELLLLDE
                     PLSGLAPEVRARTIHILREWCEIYHMTVIMTASQLQDVPACVTTVGLMEKGRLTEELPG
                     TVYHSKIKDHLILRVSDDQRASLLLEQRMGIYHYRVTEPSVILVYEQLDQAGAINRMLI
                     TEQIEVYELSYGSGKGGLISHAGGN"
     gene            complement(6961..7623)
                     /locus_tag="AR543_RS02125"
                     /old_locus_tag="AR543_02115"
     CDS             complement(6961..7623)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="AR543_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02115"
                     /product="ABC transporter permease"
                     /protein_id="WP_060531423.1"
                     /transl_table=11
                     /translation="MVNRIRSELLKYRHTFIPWMVVGAPVVIALICAWQAYSRPQGGLQ
                     IEAMIDNGLLVWFNLWLPIFCALMAGTMMHMEQWKGLLVRPLSVFSLYILKGAALLVLM
                     VLTNGLFLICLLLLSLLPAAGLTVGFWIGSWAGLALFFVPYSLALLLLAAAWGRTLTVI
                     TGVVGIIGATAWRTLTGYGVIDPTGLQLLLTAILLAGMGLLLWLGGGLWFVRRQRRW"
     gene            complement(7623..8387)
                     /locus_tag="AR543_RS02130"
                     /old_locus_tag="AR543_02120"
     CDS             complement(7623..8387)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="AR543_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02120"
                     /product="ABC transporter permease"
                     /protein_id="WP_060531425.1"
                     /transl_table=11
                     /translation="MWQGIRSEWVKYRRTAIPWILWLTPCAIAGIILMYGYPLRNGSNK
                     WIYLNLFDTVGDIWYGALIVLIWGLIAGLAAHLDIQAERWRALRSHAIAPWRLYMSKLL
                     VLIIQTLLSTVWLLILLHICMGLLYIPFSLTDSLALCGAILIGWIASLPILAASLWLAV
                     KFDWPVAVGFGSVGILIAAIIGTTHIGNGMWIALPWTWAVRAAYSAYFAMEHSLPGEDA
                     VQTLQMVLPAAACSLLLLAVLAAFWFQRREAG"
     gene            complement(8389..9150)
                     /locus_tag="AR543_RS02135"
                     /old_locus_tag="AR543_02125"
     CDS             complement(8389..9150)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="AR543_RS02135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02125"
                     /product="ABC transporter permease"
                     /protein_id="WP_060531427.1"
                     /transl_table=11
                     /translation="MNMTSYLGSEFIKYRRTLTLWLIAAGPLVFAVMQLAFNFIAPGFT
                     DWSRALMNVYNWWSVIGLPFGIILITALSVSYERKSGSPKLLQIHPVRKAGLYLSKLVV
                     LSVQVFVACLLLAAGLVIFCGWNLDGTLPWSTLLYAVGLSWLCAMGQLAIMLLLAHLLS
                     FGWTVIAGLIGLFLSIMLSSGVTGMDYYPWMLPIRALGMTLGFQTNGMSLDVQTLTNQA
                     TLVWGSVFGSLAECAIFAGLGAFIFSRKEVG"
     gene            complement(9147..9890)
                     /locus_tag="AR543_RS02140"
                     /old_locus_tag="AR543_02130"
     CDS             complement(9147..9890)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004888813.1"
                     /locus_tag="AR543_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02130"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding subunit"
                     /protein_id="WP_174703724.1"
                     /transl_table=11
                     /translation="MMEWIIETQNLTKTYGKQTALSNVNLKVSKGRVYGLLGANGAGKT
                     TLMKLLVGLLHPSSGSIRLFDEPWSRQSLARVGALIEAPALYGHLTGRENLQVHQRLLG
                     LPESRIDEVLEIVGLHQTLPKKKAAAYSLGMKQRLGIASALLNQPDLLILDEPTNGLDP
                     MGIREMRELIHSFTGQGITVILSSHILSEVSQIVHDVGIISRGEMQYQGTLDDLMQQHG
                     NQEDLEEIFMHYAAGRSGSLEGMYR"
     gene            complement(10001..11353)
                     /locus_tag="AR543_RS02145"
                     /old_locus_tag="AR543_02135"
     CDS             complement(10001..11353)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="AR543_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02135"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_060531431.1"
                     /sec_met_domain="LANC_like (E-value: 2.6e-68, bitscore:
                     228.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIVRESAQHTELSAKAKIIAMEVAERLKNPLQVKEQVMAPGNI
                     SVFGDHPWQDTLLSAGYPGIILLFGELDRQFPEDNWDMIAHDHLLALQEGLRNEGYPNA
                     SMFSGLAGVAVAIKAVSHGGTRYQGFLDKLNELIIAEVEDKLRRDEYFFYNNQGGVSPV
                     FYDVIMGLTGTGRYLLEIADEAKAKTTLCSILSYMVELAQPITINGRDVPGWYVPEKHQ
                     FTDEDKKRFPNGNFNCGLAHGIPGPMALLSIALIHNIEVEGQREAVEVMARWLIDAART
                     DESGIYWTSFISYEEQTTGQTAPERARDAWCYGAAGTARALFLAGKALDNEEFYQQGLY
                     GFDSIFKRGEAQWQLSGPTFCHGYAGLLHITSRMAAESGEERFHTYIKEVLSILLRHYD
                     PELPFVFGDLEVQEYIHKAGILDGAAGVALTLLSLDQPMDKLVWDHVFVIA"
     gene            complement(11368..13131)
                     /locus_tag="AR543_RS02150"
                     /old_locus_tag="AR543_02140"
     CDS             complement(11368..13131)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009710899.1"
                     /locus_tag="AR543_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02140"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_082472312.1"
                     /transl_table=11
                     /translation="MLWTISPGYLLIMSVINLLQGFLPALSIQATQQMINSISAGHSEM
                     VSALLFFLAIAVVYGLTSTSQNYFETLYQTKLSNHINVAVIEKSTTLSLEDFENAEMQD
                     QLKRVQNESGFRPFQIAKQIFSILSNVISLISISVIIVSWSWWAAVILIIVPAISFFTF
                     LKIGQQEFVNLWSRASKSRSAWYLSYLISRDNTFKEVKLYNLGAHFTQKYKAITDGFFK
                     QDKKLAANRVKYASLYELIEIIASFTVIVLAMLSALRGALPVGNVVAILQSITQIQSRS
                     EAVVQELLALCQNNLYLEQLFTFLDYEEKRAFSITEGEKLHAIKDIEFRDVSFQYSNSD
                     HYALHNLNFTIRTGQKIAIVGHNGSGKSTLIKLLMKLYQQSAGRILVNGQDINHWNIED
                     YQRRIGVVFQDFVQYEMSVRQNIGYGNIQEIENEEKILTSAQYAGIQPLVQSFPRGLDT
                     QLGLWFEEGHQLSGGQWQRIAIARAFMREADVYILDEPSSFLDPEAERDVFERMGRLIE
                     DRIGIFISHRLSSVNFADQIWVMDQGEIIEMGTHRELMALNGNYARMYRIQAESYASKE
                     QEEEVLHTNMG"
     misc_feature    13198..13213
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.64"
                     /tool="antismash"
     gene            complement(13231..16344)
                     /locus_tag="AR543_RS02155"
                     /old_locus_tag="AR543_02145"
     CDS             complement(13231..16344)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="AR543_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02145"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_158523919.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-173,
                     bitscore: 574.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-06,
                     bitscore: 27.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-38, bitscore:
                     131.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRTPLLPLEYFEQLCAADLQDSLDIAIQDPLVQEAIAVASENLH
                     EAMPNFKEEKNPKKQKQIAASLLKYLSRMSTRPTPFGLFASVASGNLAEQTEVNLNTKY
                     LMKRTRPDMEWLLFIVYQLEQRPEIVMQLQVQKNQAVQNTGGRIELLYPSLMGQMFNKV
                     TGTDTKPGKVTVRATPPAVRALELSEQPVAFGMIMQQMLKEYEDTEGVNAEVIFHFLWE
                     LFTKEFLISELRPPLTLSSPLDYILSRLGRIQGAEAEVELLTRAKQSMHDYDQYELGQG
                     LSSYLELQQYMKNYGEMQSMAQVDLALLSKTIHLNHQVGEDIAEVAEVLWKIAKSKRGF
                     PHLKEYHNNFIEKYGISCDVPILELLNEETGLGVPEAYLKKGNQSNDISGGTASRVEFD
                     RKLMMLMENALLNEEHEILITDDMVEQAWGDREEVDEAASSIEIYAEVLAASSQELDEG
                     KFNIVLGPNPGSFEAGATFGRFMDMLGEQPAHQFKAIRQKEQIANPDVLFAEATYIPGF
                     GRAANVIVAPNLRDYEIGIGINTSPGKEAIGLDDVLVCATHDRLVLKSRSLGKQIIVTA
                     GHMYNFQASPHIYRFMRELSFESVRTWQPFEWGSMENLPYLPRVRYRRTILAPARWALF
                     QSNFQDAGVLQDMEQWYRWMEQWRAQWRVPRFVYLMDTDNRILMDLTNKEFLKELHKEL
                     QTKKMVHLIERIGDTSDRWVQDEKGHYQTEFVFQLEKNRLQFAKPSIPTLSRTVSSENK
                     IRLPGSDWLYFKLYGGDNRQDEFITNAMYDFCQQMIEQGYCEQWYFIRYNDPDSHIRLR
                     FSGQPESLLTNLLPRVNEWAQQCLQQGLIRRVVIDTYEREVERYGGPQLIDEAEKLFSE
                     DSRTASQLVYLLRYGKTNLPPYVLGAISALNLLGQMQLSHEQMLELLSFTVDKKLYQKE
                     FREWRTPLMALYTGSSYEEVLTGMDGGEWIKQAFVERHMSADCFSRWIHEASRKNLLYN
                     NSYNIISSLLHMHFNRVFGVDREMEEKCLAFARHTIDNVIQYFKHIKR"
     aSDomain        complement(15637..15927)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AR543_RS02155_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.60E-09"
                     /identifier="RREFam001.1"
                     /label="AR543_RS02155"
                     /locus_tag="AR543_RS02155"
                     /protein_end="236"
                     /protein_start="139"
                     /score="27.1"
                     /tool="antismash"
                     /translation="AVQNTGGRIELLYPSLMGQMFNKVTGTDTKPGKVTVRATPPAVRA
                     LELSEQPVAFGMIMQQMLKEYEDTEGVNAEVIFHFLWELFTKEFLISELRPP"
     CDS             complement(16525..16692)
                     /gene="allorf_0505345_0505512"
                     /locus_tag="allorf_0505345_0505512"
                     /protein_id="allorf_0505345_0505512"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRGAFIMAEKKGMFDLDVQVLKSSEVTPQIKSKSLCTPGCNPTAT
                     LCTSCIFACA"
     CDS_motif       complement(16606..16692)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRGAFIMAEKKGMFDLDVQVLKSSEVTPQ"
                     /locus_tag="allorf_0505345_0505512_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16525..16605)
                     /prepeptide="core"
                     /locus_tag="allorf_0505345_0505512_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="8.90"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="IKSKSLCTPGCNPTATLCTSCIFACA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRGAFIMAEKKGMFDLDVQVLKSSEVTPQ"
                     /leader_location="[16605:16692](-)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
     gene            complement(16778..17410)
                     /locus_tag="AR543_RS02165"
                     /old_locus_tag="AR543_02150"
     CDS             complement(16778..17410)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="AR543_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02150"
                     /product="response regulator transcription factor"
                     /protein_id="WP_060531435.1"
                     /transl_table=11
                     /translation="MRQLSVLVTGTSDLVVRGLDSYLSKCERFSVITGKYESDCLIAQQ
                     ILEHNIDVLIADVEMNPDTYQSFAEIKQSYPELKVVLISLSNYVHPYHYTLSEIADAII
                     SKEAEIDEISNVIIMVSKNFTISNLHSKNMLSAQETEVLELMISGLTNKEIAQHLHICE
                     RTVSYYITNLFNKLNATNRVEASMKGMMQGHIRPSTIQQWMYDGKFA"
     misc_feature    complement(17437..17453)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.88"
                     /tool="antismash"
     gene            complement(17749..18954)
                     /locus_tag="AR543_RS02170"
                     /old_locus_tag="AR543_02155"
     CDS             complement(17749..18954)
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017813344.1"
                     /locus_tag="AR543_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02155"
                     /product="amidohydrolase"
                     /protein_id="WP_060531437.1"
                     /transl_table=11
                     /translation="MSEIQTLPTDLLNAQIKESIAASGEELIRLRRHLHSQPELSWEEI
                     NTTAFVCSYLDELGIRYRKTIPTGVIADIQGGKPGKTVALRADMDALSVEQIDKHLPYA
                     SQEEGKMHACGHDAHTSMLLVAARALNEVREELPGTVRLIFQPAEEVAQGAREMVRQGA
                     VEGVDNVFGIHIWSQMPTHTVACSPGPSFASADLFTVTFQGRGGHGAMPQDCIDTAIVA
                     SSFVMNVQSIVSRTVAPRQPAVVTVGKMTVGTRFNIIAEHAVIEGTVRCFDPATRDHIE
                     QQLRHYADQIAALYGATAKLEYVRGTQAVINEETSAYLVQQVAAAAFGEQVLYEEEPTM
                     GGEDFSFYLDEVPGSFALVGSGNADKDTQWAHHHGKFNIDEDALATGAELYAQYAWAYL
                     NR"
     gene            complement(18947..20185)
                     /locus_tag="AR543_RS02175"
                     /old_locus_tag="AR543_02160"
     CDS             complement(18947..20185)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017813343.1"
                     /locus_tag="AR543_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02160"
                     /product="Zn-dependent hydrolase"
                     /protein_id="WP_060531439.1"
                     /transl_table=11
                     /translation="MKQLQQRIEEHIEAISAFTATPGQGTTRLTYSPQDLQAREYIKAQ
                     MTHYGLTVREDGVGNIFGRLEGTQTDAPAVLVGSHFDSVPNGGSYDGPAGVIAGLEVAA
                     LFQENQIQPVYPLEVIAMVEEEGARFAGGLMGSRAMLGILDEQQFTHLQDKDGITTIQA
                     MEQAGLDTSLPRIRDPRTIRAFLELHIEQGPILEEKGIPIGIVEAIVGLAQLEITVQGQ
                     AGHAGTTPMDRRADALVAAAGIIAALPGIAVETGDGSVITTGKLNVWPGGANVIPDKVV
                     FTVDLRSGREENVQTLIRRTEELAASCEKGGITVSVQQQLYMKPKAMNTHIRSLLREKS
                     EQLGITHCPINSGAGHDAMVFADVTDVGMLFIPSRNGLSHCPEEWSDAADIARAVQIFY
                     ETIKSLTEVNDHE"
     gene            complement(20233..21480)
                     /locus_tag="AR543_RS02180"
                     /old_locus_tag="AR543_02165"
     CDS             complement(20233..21480)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003745720.1"
                     /locus_tag="AR543_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02165"
                     /product="hypothetical protein"
                     /protein_id="WP_060531441.1"
                     /transl_table=11
                     /translation="MSQLLALVLVVFILFVGDAVSVRTKAWIPSVFISAILFLIGYWTF
                     FPKEIVAIAGIPSTVATMLMYLLITNMGTLLSIRELKQQWKTIIIALSGVLGIVIFLFA
                     IGTFIFDYQTMLVAIPPLVGGVVSAVIMSDGAKAAGLASLSVFAIVIYVMQGFAGYPLT
                     SVMLKKEGRRLLQQYRSGQLPEHRTTAGTANVQAKGRSAAAAVSGEQVPSSRTSSELRM
                     FRWLPAQYNTEFFKFFRLALVAYIAYLVSTLLSPVVSISPFVLCLLFGIIGASTGFLEK
                     QALQKANGFGFAILGLMLFIFDGLKQATPQMMMQILPQLVGTIVIGVIGMYVFSMLIGR
                     LLKVSKEMAFSVSLTALYGFPADYIITSEVIKSLTEDEQEREMLTSRMLPPMLVGGFIT
                     VTIVSVVLAGIFVELL"
     misc_feature    complement(21474..21484)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(21772..22110)
                     /locus_tag="AR543_RS02185"
                     /old_locus_tag="AR543_02170"
     CDS             complement(21772..22110)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370578.1"
                     /locus_tag="AR543_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02170"
                     /product="darcynin family protein"
                     /protein_id="WP_060531443.1"
                     /transl_table=11
                     /translation="MRYMMVVLLEFYPSWLALPREERRMHAAGLQEIIRKHEPAVQVRF
                     FDAEALPGKDYTDFVVCETADMEQYHYMWEAIRDSEPYTKGYMKIKDVIMGMENAFQSY
                     ETNVLNMD"
     gene            complement(22305..22856)
                     /locus_tag="AR543_RS02190"
                     /old_locus_tag="AR543_02175"
     CDS             complement(22305..22856)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429920.1"
                     /locus_tag="AR543_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02175"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_227871878.1"
                     /transl_table=11
                     /translation="MAAQAGVTEEEWEHFLQQTVLRPIHSGQRLIEAGQLVNSAHFCIQ
                     GLFRLYYILEDGREYTAGFTMEQDYATSYAAMITGQPSAYTIEALEDSVVIEIPYDLLK
                     RLTRSSHAWERFVRVSVERLYIRKEERERELLYASARERYEACLRKYPGLEKRVPQYHI
                     ASYIGVSPVSLSRLLRRDSL"
     misc_feature    23045..23063
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.02"
                     /tool="antismash"
     gene            23254..24909
                     /locus_tag="AR543_RS02195"
                     /old_locus_tag="AR543_02180"
     CDS             23254..24909
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017813341.1"
                     /locus_tag="AR543_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02180"
                     /product="glycoside hydrolase"
                     /protein_id="WP_060531447.1"
                     /transl_table=11
                     /translation="MRNVHGNKTGFLPRLGALSLSVMLFSGMASSAGAAGSDHAESIAA
                     QKSTTSGVQQITINGQQRYQEIDGFGASGAWSIDHIGSEWSEKNKNKVADLLFSQDKGI
                     GLSIWRFNIGAGSVDTDQDIISDPWRRAESFKSGEDKPYDWSKQAGQQWFLQAAKKRGV
                     EETVAFVNSPPVWMTKNGHGQPDPSVGSTNLKEDYIDDYAVFLADVLEHFHKQKLGFDY
                     ISPINEPTWDWNRAGQEGNRYNIEDIKKVLIALDKELHKRGIDTEVDAIEAVEYLSLLD
                     NDMYATYTGKAGSTYTSGNAGGAFEGKYSEYIKEMLGDPQIAGIIGNKMSAHSYWSDEA
                     KPGDDRLVRLRELVRENLNRYVQDAKFWMSEYCILGDRGPGRDLTMDTALDVAKVIHYD
                     MVTTQASAWQWWLAVSKEDYKDGLVYTDYKNPGDTQSIIESKTLWALGNYSKFVRPGAQ
                     RIDLQGANDPNGLMGSAYYHDGDKQLSVVFVNSSDEAKTIHLDVTNLPGGKDVKQFKPY
                     LTSEHADLKKQSTVSVKKDITIPARSLMTLVGKN"
     misc_feature    complement(24948..24968)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.08"
                     /tool="antismash"
     gene            25342..26292
                     /locus_tag="AR543_RS02200"
                     /old_locus_tag="AR543_02185"
     CDS             25342..26292
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019450.4"
                     /locus_tag="AR543_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AR543_02185"
                     /product="copper amine oxidase N-terminal domain-containing
                     protein"
                     /protein_id="WP_060531449.1"
                     /transl_table=11
                     /translation="MNKKHISTVLLGSILAGSLVVAPLGDSVYAADTSIQIRGAYGVVP
                     SDVAPYIRNGVTMVPINVVSKLGSDNTYVSWNNTSKTVTINAAGAKTLLQLDQKYALQN
                     GARIELAQPATLKEGVVMVPLRFVGESIGVKVNWDAANRIVYIGEASSSPVDPAETSAD
                     SALQILSKQRAKVIYDLPRTELPTELPTVGMQTVTHYFPVGQANIFFEAMPDRISYYEV
                     KNNKAKEIWSANHNDQPSASGKGLPFLPYQITKEIGKRPSITATVAYYQYSASISDLRY
                     GLIDTKGNDTELGHTDPAQIKQRFPVDQKELALVK"
ORIGIN
        1 tttggaaagg aagaagggaa cgtctcccgg ttaagcctag agagaatcga atacagaaat
       61 gcaaaaagaa ccggaacagc ttgttcagca tccggttctt tgggcagatt atagtatagc
      121 gacagtccgc tatcgatttg gttgtctgtt aatttgtcat tcatattatg gcactgcaga
      181 tcctgtatca aaccgtaaca tgccatttca acttaacgat tatgaaggcg tctgagcatg
      241 gatgagtcta gaagtgaaat cgattggctg cctgctttat tgctcgctat tttccgcttc
      301 ccagcgggct acttcttcgc gtacccgtgg agcgacttct gtacccagca gttcaacagc
      361 gcgcagcaca tcgtcatgat tggacatggt gccgaccggt gtatgcagca tgaagcgggt
      421 gatccctacc tgtttgcgca ggttaataat cttggtagct acggtctccg ggtcgcctac
      481 atagagggcg ccttccagac tgcgggcagc gtcaaaactg gcacgggtat acggtcccca
      541 gccgcgctcg cgtcccagta cattcatgct cgcctgggtg gacgggaaga atttatcggc
      601 cgccatctcg gtggtatccg cgataaagcc gtgcgaatgg gaagcgacgc tgagcttgga
      661 agcatcatgt ccggcatgag cggcggcttt gtaatacagc tctacgagcg gcgcaaactg
      721 caccggacga ccaccgataa ttgccagtac aagcggcagt ccgagcagac cggcacgtac
      781 aaccgattcc gtattgccgc cgctaccgat ccagactggc aaaggctctt gaaccggacg
      841 cggatagata ccccgattgt tgattgccgg acgatgaccg ccttcccagg taactttttc
      901 cgaatcacga atcttcagca gcagttccag cttctcgtcg aacagggcat cataatcatc
      961 cagatcatag ccgaatagtg ggaaagattc gataaaagaa ccgcgtcccg ccataatctc
     1021 tgcccgtccg ttggagatcg catccagtgt agcgaactcc tgaaatacac gtaccgggtc
     1081 tgccgaagac agtacggtta ctgcactggt caggcgaata cgctcggtct gtgaagctgc
     1141 cgctgcgaga atgacagctg gagcagatgc tgcgtaatcg acacgatgat gctcgcctac
     1201 gccaaagata tccagcccta ctttatctgc gagtacgatc tcgtctacga cctggcgaat
     1261 acgctcagcg tggctgatag tctttcctgt ctctgtatct ggtgttgttt ctacaaatgt
     1321 actgattccg atttccataa ttatatcctc ctgttgggtg ggctttgcca tattggcaag
     1381 ccatcgtttg ctgtctcagc aagccgtcgt ttgctgtttt cagcaagccg tcgtttgctg
     1441 ttttcagcaa gccgtcgttt gctgttataa catcacgtta tatgctgttg tatcgttgtt
     1501 gggttcgtta tatttattgt gtttattgtt aatcgaatgg gatggattgt ataactacca
     1561 agctgttttc caaaatatct ttaaatcgaa atattatatt atctttattt aaaactattt
     1621 tctggtatat tgcaagcatt atgtaacaat cgctgctact tttgccaagc tgttcttttt
     1681 gctattggga tagaatgcgc tctttttatt ttgaaaatag acagctgccg tataatgtca
     1741 ccctgctatg tggttctgct gtatattctt cctgctgtag tcattattat tgtgcactgg
     1801 tatagaaagt tacgtacgaa aaagacacag ccgcgtatct gcgctgtgtc tttgaaatac
     1861 atactaattc tttttcacaa attccgattt gagcttcatg gcgccgaatc cgtcgatttt
     1921 gcagtcgatg ttatggtcgc catccaccag acggatactt ttgacgcggg taccgatttt
     1981 gagtacagag gagcttcctt ttaccttgag atccttgatc actgttaccg catcgccatc
     2041 ctgcaaaata ttgccgttgg catcccgtac cacaagtgcg tcttccgtgc tgtctacatc
     2101 ttcacccggt gtccattcgt gggcacactc cgggcagatc agcagattgc catcctcata
     2161 cgtgtacgcg gaattgcatt ccgggcagtt cggtaaatct gtcatacctt cacttctcca
     2221 tttcgttgtc ggatttgtct attttcccat agtccggtgc agctgacaat gttttgggta
     2281 ttctttttgc cgttcatggt tccctgacag tccagttgtg tagtatatag tagtctctga
     2341 cgccgaacca ttacagcagc tatattcttt tgccctgctg tctttacata gcatgaccta
     2401 tacctgtgaa attggaaagg agtgaatgtg ttgagcgatt cgattctgcg cgcttttaca
     2461 ctcaaaaaca gtctcaagct gctgcgtccg gcagccgtgc tctgttccag tgtagccatt
     2521 attttctccg gcgtgttccc gctggctgcc tattatgaat tgtcggtctc ttcgctggtg
     2581 attactgcat tgctgctgct gattggatgt attctgatcc atggcgtact gactcatgcg
     2641 ctgaatgatt atgccgatta tctgtccgga accgatcagc tcagtccggc catgctatcc
     2701 ggcggcagcc gggttattca ggaaggacgg atttctccgg ctgccctgca ccgatttggt
     2761 atcggcctta cgattgtgct tatagcagct acagcgatca ttgccttgtt cggtcattac
     2821 gcactggccg ccctgctgct catcggaata tggggcgcgg tctcctattc gctgcctccg
     2881 ctgcgtttca gttatgctcc cctggctgga gaatggctga gcacgttccc gtccaccttt
     2941 ttcctgggac ttggcggtgc ctggctgatg ctcggtacat tcccgcagtg ggccgtacag
     3001 aatgcgctga ttaatgcact gtactgcgtc gcctgggtta tggtgcatca tattcccgat
     3061 ctggacgcgg atcgccaggc ctccccggtc aagcgtacca gcgtcgtctg ggcagcagac
     3121 cgatggggaa tcggctacag ccgactgccg gcgctggtat acctgggtct aatcgcactt
     3181 tgtgtcgtct ggttgctggg aaccggacga ttatggggag ccgccggtat cgctgtcatg
     3241 gtcgctctgt cggtgtactg gatctgccgg atggatgtac gcgatccgga acaggttacg
     3301 aactgcgaga aaaagctgct gctgctcgca gtaggtggag cagtatggct ggggattttc
     3361 atttgaatat gggattacaa attaacaggg aattgctgtt tgctccaagc attcggcaat
     3421 tccttgtttg tggaatagaa cattactgtg gatattcacg gcaagaaata cactgctact
     3481 tatacggcag aagacaatgc ttactttgac cagttaagat atggagctat cagcatctat
     3541 tcgattcaca atcatcaatt gactgctact gtgagcggta atttccatgt tgctatgttt
     3601 gcaggtgatg tgaagattac gtatcgttat gactcagcga gtcaacgatt taagccggat
     3661 cagttaaagt ttattcctct ttccccaggt ccctttccag acagaactta aatgaagttc
     3721 gtacataggg cgtactctcc acccgaatct gcccatgctg cttctctacc agctttttgg
     3781 tgatagccag ccccaggccg cttccggcag gggagtggcg gctggcggat gcctgataca
     3841 gccggtcaaa cagcagagga agctcgtctg ctgggatgcc ttctcccgtg tcccatactt
     3901 ccacccaggc ctggtttctt tctgcccaca gacggatgcc gtgtcgtcct tcacctccgt
     3961 gcccgtaccg gatcgtattg gagatcagat tggacaggat acgctccaca ctgaccggat
     4021 cagcctgaac gagaacaggg gcggcgggta attccagttc gggcggtatg ccccatttct
     4081 cgaattggtc gatcacctgt acgatacatt cttcgatctt ggccgtcaga ttgacctgct
     4141 gaaagtgaat ctggatatcc ccggattcca gccgtgtcca ttcgaagaaa ttcccgagca
     4201 gctgggtcag cgccctagct ttgtcaaaaa taatatccct gtatttcccc gacagttccg
     4261 ggtcctgaat cactttcggg ttttttagca tctcggcata cccggacagg gaagtgagcg
     4321 gtgtcctcag atcatgagcg atatgggtca tgacctgccg ctgcgttttc tccagctgca
     4381 tcgcctgatt atggaacaga tagattcggt cgcgcagcag attgagctgt ccggcgagcc
     4441 gattaatcac cgaaatccgg ctgcggatat gcaaataggc aggctgcgga tcacgctgca
     4501 gcctgtccag catctgtacc atctgctgca gctgacggtg aatcactcca atataaatgg
     4561 ccagcgccac accgaccaca ctgacgatca ccagcaggat atcggtcatt attcctcctc
     4621 ctcattccct ccaagacgat agccgattcc ccagacagtc tgaacatata ccggggaaga
     4681 cgctttgtct tcgatcttcg tacgcagccg ccggatatgc accattaccg tattctcatc
     4741 tacatcagag gaatacggct cttcccagac cgattcgaag atctgggatt tggtaaatac
     4801 gcgctgcggc tgcgacatca gcagctgtaa aatggcaaat tccttagcgg tcagtgtacg
     4861 atgctctccc cggattcgta cctgatatgt actgccgtcg agctccagct ctttgtattt
     4921 ccatactttg tgggcgggct gctcggattc gctgtagtaa aagtacctgc gcagctgcgc
     4981 tttgacccgt gccagcagct caccaagcag aaaaggcttg gtcagataat catccgctcc
     5041 accggccaat ccggcaattt tgtcgatctc ggcatccttg gcagacagaa gaagcaccgg
     5101 gatttttttc ttttcccgga tgcgtcgcag cacttccagt ccatccagac ctggcagcat
     5161 aatatccaga atgaccagat cgtaatcggc tgcttcaaat tcccgaatag cctccaatcc
     5221 gttatgtatc tgaatcacgc cataattttc cccgatcagc gtctgggcga tcagatcgca
     5281 tatctcgata tcatcctcaa cgatcataat tcgggccagt gtcatcgatc tattcatctc
     5341 ctctgcaatc tcctgtacat ccatccgccc cataccaggc atatcgctcc cagcactgca
     5401 tagatcacca gtggataagc ctgatccggc catgtccctt ttcccgttcc gtgtaaatag
     5461 atggaaggaa ccagccacgg atagtatatg atccagtccg gtacccggat gatcagtacc
     5521 agcccgagca ggaactgtcc caacagtacg atggtcaaat acagcgatgt ccggctgatc
     5581 agagccagta cggcaccata tgccgagaaa ccggcataaa ttatccagga gacgaccaga
     5641 tccttgatga accatttacc cagcgcagct gccgacacag aaacatccag cgcccacagt
     5701 ccaattaaca gcgtaattag ctccgatccg aatagcagca gacccatgag cagcagactg
     5761 gtgaggattt tggcggtata ccattctccc cagtgaaaag ggtacgtctt gtgcagactc
     5821 agcagcccgc gatcccgatc ccgtgtaaac aaataaccgg ccaaaaaagt aaaaaaagtc
     5881 ggccggaacc acaaattcat ataagtctga tccattaggt gctgccagct tccgctgtct
     5941 gccttgagca gcgtaatgag cagctgcagc accaatagca ggatcattaa ccgcagcaca
     6001 acagagcgtc taaataaaag aagttccctg aaaatgagtg tcagcatcag tttcctccag
     6061 catgtgagat aagtccgcct ttaccggaac cgtaactcag ctcatacact tcaatctgct
     6121 cggtaatgag cattcggttg atggcgcccg cctgatccag ctgctcatag acgagaataa
     6181 ccgacggctc ggtcacccgg taatgataga tgcccatacg ctgttccagc agcaggctgg
     6241 ctctctgatc atcgctcact ctcagaatca gatgatcttt aattttgctg tgatagacgg
     6301 tgcccggcag ttcttcggtc agtcgtccct tttccatcag tccgactgtc gtcacacagg
     6361 caggtacatc ctgcagctgg gatgctgtca tgatcacggt catatggtaa atttcacacc
     6421 attcccgcag aatatgtatc gttcgtgcac gtacttcagg tgctaatccg ctcagaggct
     6481 catccagcag cagcagctcc ggccggtgca gcagtgctct cgcaattgca cagccgcgtg
     6541 ccgcttctgc cggaatccgg ccagcacgct gatgggcgta cttttccagt gacagtagtt
     6601 ccagcatggt atgggaagcc tgtttgtccg gcactcccat catccggcgg tgaagttcca
     6661 gatgttcata caccgtcaga ttcgggacaa aggatagcgg ttcgcacata acgccaatcc
     6721 tgtttttcca cacataatca gagtggatat tgatgctgcc gaaccattcc agcttgccgg
     6781 atagcggcac aagatcaccg gccagcccgc gcagcagcgt tcgtttgccg ctgccctttt
     6841 cacccaggat gacataaaat gcccctcgct gcacatccat attgagccgt tccacccgga
     6901 caccggagtc gccggccgac aagcagagat gatctgcatg tataagccta tcaggatgat
     6961 ctaccatcgt ctctgtctcc ttacaaacca tagtcctcct cccaaccaga gcagcaggcc
     7021 catacccgcc agcagaatgg cggtcagcag cagttgtagt ccggtcgggt ctatcactcc
     7081 atacccggtc agcgtgcgcc aggcggtagc tccaataata ccgactactc ctgtaatcac
     7141 ggttagtgta cgcccccagg ccgctgccaa cagcagcagt gccagactat agggtacaaa
     7201 aaacagcgca agtcctgccc agctgccaat ccaaaagccc accgtcaaac cggcagcagg
     7261 cagcagactg agtagcagca ggcagatcag gaacaagccg ttggtcagta ccatcagcac
     7321 cagcagcgcc gcccctttga gtatataaag ggaaaatacg gacaagggtc tgaccagcag
     7381 acccttccac tgctccatat gcatcatcgt gccggccatc agcgcacaaa aaatgggcag
     7441 ccacagatta aaccatacca gcagaccatt atcgatcatc gcttcgatct gcaatccacc
     7501 ctgaggcctg ctgtacgcct gccaggcaca gatcagggca atcactaccg gtgcaccgac
     7561 gaccatccat ggaataaagg tatggcggta tttcagcaat tcggatctga tgcggttgac
     7621 catcagcctg cctcccttcg ctgaaaccag aatgcagcca gaacagccag cagcaacaga
     7681 ctgcaggcag ccgctggcag taccatctgc agcgtctgaa cggcatcctc gccaggcagg
     7741 gaatgctcca tcgcaaagta ggctgagtag gctgcccgca cagcccacgt ccacggaaga
     7801 gcaatccaca tcccgttacc gatatgcgtc gtgccgataa ttgccgcaat cagaatgcca
     7861 acactaccaa agcctactgc tacaggccaa tcgaacttga cagccagcca caaggaagca
     7921 gccagaatcg gcagtgaagc gatccatccg atcagaatcg ctccgcacaa agccagcgaa
     7981 tcggtcaggg aaaacggaat atacagcagc cccatgcaga tatgcagcag aatcagcagc
     8041 cagaccgtac tcagtagcgt ctgtatgatc aaaacgagca gcttgctcat atacagccgc
     8101 cagggggcaa ttgcatggga gcgcagcgcc cgccaacgct cggcttgaat atccagatgg
     8161 gcagccagac cggcgatcag tccccagatc aatacaatca atgcaccata ccatatatct
     8221 cctacagtat caaaaagatt taaataaatc catttattag aaccatttcg cagcggatag
     8281 ccatacatga ggataatacc cgcaatcgca cacggggtca gccagagaat ccatggtatg
     8341 gctgtccgcc gatactttac ccattccgat cggataccct gccacacgtt acccaacctc
     8401 ttttcggctg aaaataaatg cgcccagccc ggcaaagatc gcacattctg ccagactgcc
     8461 gaatacactg ccccagacga gtgtcgcctg gttcgtgagg gtctgcacat ccagcgacat
     8521 gccattggtc tggaatccca aagtcatgcc cagtgcccgg atcggcagca tccatggata
     8581 atagtccatt ccagtcacgc cgctgctcaa cataatggac agaaacagac cgatcagacc
     8641 ggcgatcact gtccagccaa atgacagcag atgggcaagc agcagcataa tcgccagctg
     8701 tcccattgca cacagccagg acagccccac tgcatacaac agtgtactcc acggcagcgt
     8761 accgtccaga ttccaaccgc agaagataac cagtccggct gccagcagca ggcaggcgac
     8821 gaatacctgc acagacagga cgaccagctt ggacaggtac agacctgctt tgcgaaccgg
     8881 atggatctgg agtagcttgg gcgatcccga tttcctttca taggagacgg acaaggccgt
     8941 aatcagaata atgccaaaag gcagaccgat caccgaccac cagttgtaca cattcattag
     9001 cgcccgcgac cagtcggtga acccaggtgc aataaagtta aaagccagct gcataacagc
     9061 aaaaaccagc ggcccggcag cgatcagcca gagggtgagc gttcggcggt atttgataaa
     9121 ttcggagccc agataagagg tcatattcat cgatacatcc cctccagtga tccgctacgg
     9181 cctgcggcat agtgcataaa gatttcttcc agatcttcct gattgccatg ctgctgcatc
     9241 agatcatcca acgtaccctg atactgcatc tcaccccggc tgataatgcc cacatcatgc
     9301 acaatctggg atacttcgct cagaatatgg ctggacagaa tcactgtaat tccctgtccg
     9361 gtaaaggaat gaatcagctc tctcatctcc cggatgccca tcggatcgag tccattggtc
     9421 ggctcatcga gaataagcag atccggctga ttgagcagcg cggaagcgat gccgagacgc
     9481 tgtttcatcc cgagtgaata cgcggcagcc tttttcttgg gcaaggtctg gtgcagaccg
     9541 acaatctcca gcacctcatc gatccgactc tccggcagac caagcagacg ctgatgcacc
     9601 tgcagattct ccctgccggt caaatgccca tacaaagcag gagcttcgat caaagcccct
     9661 acccgtgcca gtgattgtct gctccatggc tcgtcaaata aacggatact gccggaagac
     9721 ggatgaagca atccgaccag cagcttcatc aatgtcgtct tgccggctcc gttcgcgccc
     9781 agaagtccat atactcttcc tttgctcact ttgagattga cgttggaaag tgcggtttgc
     9841 ttgccatagg ttttggtcaa attctgcgtc tctataatcc attccatcat atagcctcct
     9901 tgttctattc atcgttatct tcatgatata gaacaaatct taaccggcat tgaagcaagt
     9961 cttacgaatt ccttacatcg ctgtatgaat agtcatagga tcaggcaata acaaagacat
    10021 gatcccatac cagtttgtcc atcggctgat ccagggacag cagtgtcagg gctactccgg
    10081 ctgctccgtc cagtatcccc gctttgtgga tatactcctg cacttccaag tcaccgaata
    10141 caaagggcag ctccggatcg taatggcgga gcaaaataga cagcacttcc ttgatatagg
    10201 tatgaaagcg ttcctctccg ctctctgctg ccatgcgtga cgtaatatgc agcagaccgg
    10261 catatccatg gcaaaaagta ggcccggaca gctgccactg cgcttctcct cttttgaaaa
    10321 tagagtcaaa tccgtataat ccctgctgat aaaactcttc attatccagc gccttgccgg
    10381 ccaaaaataa ggcacgtgct gtacctgctg ctccatagca ccatgcatcc cgtgctcttt
    10441 ccggagctgt ctgccctgta gtttgttcct cataggagat aaagctggtc caatagatgc
    10501 cgctctcatc ggtgcgggct gcatcgatta gccaacgggc catcacttcg acagcctccc
    10561 gttgcccttc gacttcaata ttgtgaatca gtgcaatact cagcagtgcc attgggccgg
    10621 gaatgccatg agcaagacca cagttgaaat tgccattggg aaacctcttt ttgtcttcat
    10681 ctgtaaattg atgcttttca ggcacatacc aaccgggtac atcgcggcca ttgatcgtaa
    10741 tcggctgggc cagctctacc atataactca ggatgctgca cagggtggtc tttgccttgg
    10801 cctcatcggc aatctccagc agatagcggc ctgtaccggt gagacccata ataacatcgt
    10861 agaatacggg tgatacgcct ccctgattat tgtagaaaaa atactcatcc cgtctgagct
    10921 tatcctccac ttctgcaata atcagctcat tcagcttatc gagaaatccc tgatagcggg
    10981 ttccaccgtg tgataccgct ttaatggcta ccgccactcc cgccaatccg ctaaacatgg
    11041 acgcattggg ataaccttca ttgcgcagtc cttcctgcag ggcaagcaga tgatcatggg
    11101 caatcatatc ccaattatct tcagggaact gtcggtccag ttctccaaac aataaaataa
    11161 tgccaggata acctgccgac agcagtgtat cctgccatgg atgatctcca aaaacagaaa
    11221 tattaccagg cgccatcacc tgctctttga cttgcagagg attctttaga cgctcggcca
    11281 cctccatcgc gatgattttg gcttttgctg acagctctgt atgttgcgcg ctttcccgga
    11341 caatttcact catatgtgca gtctccttta tcccatattg gtatgcagaa cttcttcttc
    11401 ctgttccttg ctggcatacg attctgcctg tatacggtac atgcgtgcat aatttccatt
    11461 cagagccatc agctctctat gggtccccat ctcgataatt tcgccctgat ccatcaccca
    11521 gatctgatcc gcaaaattaa ccgaagacag ccggtgtgag ataaaaatac caattcgatc
    11581 ttcaattaaa cgacccatcc gctcgaatac atcccgctcg gcttccggat caagaaacga
    11641 actgggctca tccagaatat agacatctgc ttcccgcata aaagctctcg caatcgcaat
    11701 ccgctgccat tgtccgccgg ataattggtg accttcttca aaccacaatc ccagctgggt
    11761 atcgagtcct ctcgggaaac tttgtactaa cggctgaatg cctgcatatt gggcagaggt
    11821 cagaattttc tcttcatttt cgatttcctg aatatttcca tagcctatat tttgccggac
    11881 cgacatttca tattgcacaa aatcctgaaa tactacacca atccggcgct gatagtcctc
    11941 gatattccag tggttgatat cctgtccgtt caccagaatc cgaccggctg actgctgata
    12001 gagcttcata agcagcttga tcagcgtcga tttacctgat ccgttatgcc cgacgatagc
    12061 tattttctga ccggttcgaa tcgtaaaatt caggttgtgg agtgcatagt ggtccgagtt
    12121 cgaatactga aaggaaacat ccctgaattc tatgtccttg atagcatgca gcttttcgcc
    12181 ttctgtaatg gaaaaagccc tcttttcctc ataatccaga aaggtaaaca gctgttccag
    12241 ataaagattg ttctggcaca aagcaagaag ctcctgtaca accgcttccg aacgactttg
    12301 gatctgggta atggactgca aaatagcaac tacgttgcct acgggaagcg ctccgcgcag
    12361 tgcagacagc attgccagca caataaccgt gaatgaagcg ataatctcga tcagctcata
    12421 cagggaagca tattttacac gattggccgc cagctttttg tcctgtttga aaaatccatc
    12481 ggtaatcgct ttgtactttt gggtgaaatg tgctcccaga ttgtaaagtt tcacttcttt
    12541 gaacgtatta tccctggaaa tcaaataact caaataccag gcagatctcg atttggaagc
    12601 tcggctccac agatttacaa actcctgctg tcctattttc aaaaaggtaa aaaacgatat
    12661 ggctggcaca atgatcagaa taaccgcggc ccaccagctc cagctcacaa taataacaga
    12721 gatcgagatc agggaaatca cattgctgag aatcgagaaa atctgcttgg caatctggaa
    12781 cggacgaaat cccgactcgt tctgcacacg tttcagttga tcttgcatct ctgcattttc
    12841 aaaatcttca agagaaagag tcgttgattt ctcaataacc gctacattga tatgattgga
    12901 caacttggtc tgatacagcg tctcaaaata attctgggat gtagatgtca gtccatatac
    12961 caccgcaata gccaggaaaa acagcagtgc actcaccatc tcggaatgcc ctgctgaaat
    13021 ggaattgatc atctgctggg tggcctgaat ggacaaagct ggcagaaaac cctgaagcag
    13081 attgataacc gacatgatta gcagatatcc cggtgaaatg gtccataaca tctgaaatac
    13141 tctgggccag tagcgaaagg atcttataat attggaaatg cccggctctt gcccggttcc
    13201 aactcctgtt ccatcagaca cctgtctcac ctacctcttg atatgcttga aatactggat
    13261 gacattatcg atcgtatgtc tggcaaatgc gagacatttc tcttccatct cccggtcgac
    13321 gccaaataca cggttaaaat gcatatgcag cagactggag atgatattat agctgttgtt
    13381 gtacagcaag tttttgcggc ttgcttcatg aatccatcgg ctgaagcaat cggccgacat
    13441 atgcctttct acaaaggcct gctttatcca ttctcctccg tccatccctg tcagtacttc
    13501 ttcataggaa cttccggtat agagcgccat gagtggtgta cgccattcac ggaattcttt
    13561 ttgatacagc tttttgtcca cggtaaaact cagcagctcc agcatctgct catgcgataa
    13621 ctgcatttga cccaacaaat tcagtgcact gatcgctccc agcacataag gcggcagatt
    13681 ggtcttgcca tagcgcaaaa gatagacaag ctggcttgcc gtccggctgt cttccgagaa
    13741 cagcttctct gcttcatcga taagctgcgg acctccgtac cgttccactt cccgttcata
    13801 cgtatcaata acgactctgc ggatcagtcc ctgctgcaga cattgctgtg cccactcatt
    13861 gacacgcggc agcagattcg tcaaaaggct ctccggttgt ccactgaaac gaagccggat
    13921 atgagagtcc gggtcattgt agcgtatgaa ataccattgc tcgcagtacc cctgctcgat
    13981 catctgctgg caaaagtcat acattgcatt ggtaataaac tcatcctggc ggttatctcc
    14041 gccatacagt ttaaagtaca gccaatcact gcccggcagt ctgattttgt tttcggaaga
    14101 tacggttctc gataaggttg ggatacttgg tttggcaaac tggagtcgat ttttctccag
    14161 ttgaaatacg aactcggtct gataatgccc tttctcatcc tgcacccagc gatcacttgt
    14221 gtctccgata cgctcaatca gatgtaccat ctttttcgtc tgcagctcct tatgaagctc
    14281 tttaagaaat tctttattcg tcaaatccat caggatgcgg ttatcggtat ccatcaaata
    14341 gacaaagcgc ggtacacgcc actgagctct ccactgttcc atccatctat accactgctc
    14401 catatcctgc agcactccag catcctggaa attggattgg aacagggccc atctggccgg
    14461 agcaagaatg gtgcgccgat agcgaactct tggcaaatac ggcaggttct ccatagatcc
    14521 ccactcaaac ggctgccagg tacgcacaga ttcaaaggaa agttcacgca taaaacggta
    14581 aatatggggg gaagcctgga aattgtacat atgtccagct gttacaataa tctgttttcc
    14641 cagtgatctg gatttcagta ccaatcggtc atgagtcgca cagaccagca catcgtccag
    14701 accgatcgct tcttttcccg gtgacgtgtt gatcccgatt ccaatctcgt agtctctcag
    14761 attgggagcc acgatcacat tcgctgctct tccaaaacca ggaatatatg tagcttcagc
    14821 aaaaagcaca tccgggttag cgatctgctc tttctgacga attgctttaa actgatgtgc
    14881 cggctgttct cccagcatat ccataaatcg gccaaacgta gcccctgctt caaaagagcc
    14941 aggattggga cccaatacga tgttgaactt gccctcgtcc agttcttgcg acgaagccgc
    15001 cagcacttcc gcatatattt caatagagct tgcggcttcg tcgacttctt ccctgtctcc
    15061 ccacgcctgc tctaccatat cgtcggtaat cagaatttca tgttcttcgt ttaataaagc
    15121 attttccatt agcatcatca gtttgcggtc gaattcgact ctgctggctg ttcctccact
    15181 gatgtcgttt gactgattcc ctttttttag ataggcttcc ggtacaccaa gcccggtctc
    15241 ttcgttgagc agttccagaa taggaacgtc gcatgatatg ccatactttt cgataaaatt
    15301 attgtgatat tctttcagat gcggaaatcc tcttttactt ttggcgattt tccataatac
    15361 ttcagctact tcagcaatat cctctcctac ctgatgattc aaatggatcg tcttggacag
    15421 taatgccaga tcgacctgag ccattgactg catttcacca taatttttca tatattgctg
    15481 taactccaga taagaagaca gtccctgtcc cagttcatac tgatcataat cgtgcatcga
    15541 ctgcttggct cgggtcagca attcaacttc cgcttcagca ccttgaatcc gtcccagccg
    15601 gctcaaaatg taatccagtg gagaagataa ggtcaaaggt ggccgcagct cgctaatcag
    15661 gaattctttg gtaaacagct cccacagaaa atgaaaaatc acttccgcgt taactccttc
    15721 ggtatcttcg tactccttga gcatctgctg cataatcatg ccgaatgcaa ccggctgttc
    15781 actcagttcc agtgcacgga ctgctggcgg agtggcccgc actgttactt tgccaggttt
    15841 ggtatccgtt ccggtgactt tgttgaacat ctggcccatc agcgatggat acagcagttc
    15901 aatgcgtccg cctgtatttt gtacagcttg gtttttttgt acctgcagtt gcataacgat
    15961 ttccggacgc tgctccagct ggtatacgat aaataacagc cattccatat ccgggcgtgt
    16021 acgtttcatc agatacttgg tgttcaggtt cacctctgtc tgttcggcca ggttccctga
    16081 tgcaaccgat gcaaacaggc cgaatggtgt aggacgggta gacatcctgg acagatactt
    16141 tagcagactc gcagcgatct gtttctgctt tttgggattc ttctcttctt taaaattagg
    16201 catggcttca tgcaggttct cactcgctac ggcaatcgct tcctggacca gcggatcctg
    16261 aatggcaata tccagcgaat cctgaagatc tgccgcgcat aactgttcaa aatactccaa
    16321 cggcagtagg ggagttctca tcataaacag ggataatgga gaataaatct tctctttttt
    16381 tgacttcttc tcaggcacca tggtttttat ctgcaagcca tttctccacc tttcatcaat
    16441 tgaatcctcc atgcaaaata taaaaaggag aggagagaag aatatgaata ttctctctcc
    16501 tctccttgca ccgcaggcta catattaagc acaggcgaag atgcagcttg tacacagggt
    16561 agctgtagga ttacagcccg gtgtgcaaag ggacttactt ttgatttgag gagtaacctc
    16621 ggaactctta agtacttgta catccaaatc gaacatgcct tttttttctg ccattatgaa
    16681 tgctcctctc aataaatgta ttagatctag atctgatatg agattaacat taaaaggaat
    16741 ttattataat gtatttccat gcgtttcttt tgcgtgatta cgcaaactta ccatcataca
    16801 tccattgctg tatcgttgat ggacgaatat gcccctgcat cattcctttc atggaagctt
    16861 ctacccggtt ggtggcattc agtttattga aaaggttggt tatgtaataa gagactgtcc
    16921 gttcacaaat atgtagatgc tgagcaattt ccttgttggt caatccgcta atcatcagtt
    16981 ccagtacttc ggtctcctgt gcagacagca tattcttgct gtgcagatta gagatggtaa
    17041 aatttttgct gaccataata atcacattgg aaatctcatc aatttccgct tctttggaaa
    17101 tgatagcgtc tgcgatttca ctcagagtat agtggtaagg atggacataa ttggagagtg
    17161 agatcaggac tactttgagt tccggatagc tttgcttgat ttcagcaaaa gattggtagg
    17221 tatccggatt catctctaca tcagcaataa gcacgtcgat gttatgttcc aaaatctgct
    17281 gagcaatcaa acaatcggat tcgtattttc cggtaatcac gctaaacctt tcgcacttgc
    17341 tcaagtacga atccagccct cttacaacca aatcacttgt tccagtcacc agtacagata
    17401 gttggcgcac aattcttcct ccctattagt aataatttgt aaaactatta caatgcccat
    17461 tcttttccat attacaatgg atttaataac cattaaaagt taaaaattgt caataaatat
    17521 ataaaataca ggaaatgttg catgcaaaat aattagcaaa ttgagggatc tttttagtgc
    17581 tataaatcgt atccagacgg agaatccaac tcgcctacct tcataagcag aacccgatcc
    17641 taaccctaat tcatctgtgc gttataaaat aaagaaacag taaaaagccg ttggatctac
    17701 tccaacggcc tttcttttat ataacattcc cgacattcac ttccgcaatc aacgattcaa
    17761 atatgcccat gcatactgcg catacagctc tgctccggtc gccaaggcat cttcatcaat
    17821 attgaacttg ccatgatgat gcgcccactg tgtatccttg tcggcattgc cgctgccaac
    17881 cagtgcaaag ctgccgggta cctcgtccag ataaaagctg aagtcctcgc cgcccatcgt
    17941 cggctcctcc tcatacagca cctgttctcc aaaagctgct gcagctacct gttggaccag
    18001 atacgcactg gtttcctcat taatgactgc ctgggtaccg cgtacatatt ccagtttggc
    18061 tgtcgcccca tacagcgcag cgatctgatc agcatagtgc cgaagctgct gctcgatatg
    18121 atcgcgggtc gccggatcaa agcagcgcac cgtgccttcg atcacggcat gttcagcgat
    18181 aatattgaat cgggtaccta ctgtcatttt ccctaccgtt acgaccgcag gctgtctcgg
    18241 cgccacggtg cgtgagacaa tcgactgcac attcatgaca aaggaagaag cgacaatcgc
    18301 cgtatcaata caatcctgcg gcatcgctcc atgtccgcct cgtccctgga atgtcacggt
    18361 gaacagatcg gccgaggcaa aggaagggcc cggactgcag gccaccgtat gggtaggcat
    18421 ctgcgaccag atatgaatgc caaacacatt gtctacacct tccaccgctc cctggcgtac
    18481 catctcgcgc gcaccctggg caacttcttc tgccggctgg aaaataagcc gtacagttcc
    18541 cggcagctct tccctgacct cattcagcgc ccgcgcagca accagcagca tggaggtatg
    18601 cgcatcatgg ccgcaggcat gcattttacc ttcttcttgc gaagcatatg gcagatgctt
    18661 gtcgatctgc tccacagata gcgcatccat atcggcacgc agagcaacgg ttttgcccgg
    18721 cttgccgccc tgaatatccg cgatgactcc agtcggtatc gtcttgcgat agcggatgcc
    18781 cagttcatcc agataactgc agacgaatgc ggttgtgttg atttcttccc aggacagctc
    18841 gggctggcta tgcagatgac ggcgcagccg gatcagttcc tcaccggaag cggctatgct
    18901 ttccttgatt tgggcgttca gaagatcggt tggcaaggtc tgtatttcac tcatgatcat
    18961 tcacctccgt cagggatttg atcgtttcat agaaaatctg tacagctctc gcaatatccg
    19021 ctgcatccga ccattcttcc gggcagtggc tgagtccatt acggctcggg ataaacagca
    19081 ttcccacgtc ggtcacatcc gcgaatacca tagcgtcatg accggcgccg ctgttgatcg
    19141 ggcagtgggt gataccgagc tgttcacttt tttcccgaag cagggagcgg atatgtgtat
    19201 tcatcgcttt gggcttcata tacagctgct gctgtacgga tacggtgatg cctccctttt
    19261 cacaggaggc ggccagttcc tcggtccggc ggatcagggt ctgtacattt tcttcacgtc
    19321 cggagcgcag atcgacggta aagaccactt tgtccggaat aacattggcg cctcccggcc
    19381 atacattcag cttgcctgtt gtaataaccg atccgtctcc tgtctccact gcaatccctg
    19441 gcagcgcagc gatgatgcct gccgcagcca ctagcgcatc tgcacgtcga tccattggag
    19501 tcgtaccggc atgtcccgcc tgaccctgta cggtaatctc cagctgggca agtccgacga
    19561 tggcttcgac aataccgatc gggatacctt tttcctccag aataggtccc tgctcgatat
    19621 gcagttcgag aaaagcgcga atcgtacgcg gatcgcggat tctaggaagc gaagtatcca
    19681 gtccggcctg ctccatcgcc tgaatcgtcg taatcccgtc tttgtcctgc agatgggtga
    19741 attgctgttc atccagaatg ccgagcatgg cgcgcgaacc catgagacca ccggcgaatc
    19801 gggcaccttc ctcttcgacc atggcgatca cttcgagcgg atagactggc tggatctgat
    19861 tttcttgaaa cagtgcagcc acctccagac cggctattac accagccggg ccatcgtagc
    19921 tgccgccgtt tggcaccgaa tcaaaatgcg atccgaccag tacagccgga gcatccgtct
    19981 gtgtaccttc cagtctgcca aaaatattgc cgactccgtc ttctcttacg gtcagtccat
    20041 aatgggtcat ctgcgccttt atatactcgc gggcctgcag atcctgtgga ctgtaggtga
    20101 gtcttgtcgt cccctgtccc ggtgtagccg taaaggcact aatggcttca atatgttcct
    20161 cgatccgctg ttgaagctgc ttcatggtca ttccctccct gattgttctg cttggtacct
    20221 gaataatcta ttttataaaa gctccacaaa aattccggcg agcactaccg acacgatcgt
    20281 gacggtaata aatccgccaa ccagcatcgg cggcagcatg cggctcgtca gcatctcgcg
    20341 ttcctgctcg tcttctgtca gtgattttat cacttccgac gtaatgatgt aatccgccgg
    20401 gaatccgtat aatgcagtaa gcgagacaga aaaagccatt tccttgctta ctttgagcag
    20461 tcttccgatc agcatggaga acacatacat accaatgact ccgataacaa ttgtcccgac
    20521 aagctgtggc agaatctgca tcatcatctg cggagtcgct tgcttgagtc cgtcaaaaat
    20581 aaacagcatc aggccaagaa tagcaaaacc gaatccattc gctttttgca gagcctgttt
    20641 ctccaggaaa cctgtacttg ctccgataat cccgaacagc agacaaagca caaatggact
    20701 gatgctcact accggactga gcagggtaga gaccagatag gcaatatacg ccacaagagc
    20761 cagccggaaa aatttgaaaa attctgtatt gtactgcgca ggcagccagc ggaacatccg
    20821 cagttcggag gatgtccggg atgaaggaac ttgctctcca cttacagcag ccgcagccga
    20881 tcgacctttg gcctgtacat ttgctgtgcc agcagttgta cgatgttcag gcaactgacc
    20941 gctgcgatac tgctgcagca gccgtcgtcc ttcttttttc agcatcaccg aagtgagtgg
    21001 atagccggca aagccttgca tcacataaat aacgatagca aataccgaca gcgaagccag
    21061 cccggccgcc ttggcgccat ccgacatgat aacagccgat actaccccac caacgagcgg
    21121 cggaattgcc accagcatcg tctggtaatc aaaaataaat gtacctatgg caaacaggaa
    21181 aataacaata ccaagtacac ccgacagcgc gataataatc gttttccatt gctgcttgag
    21241 ctcacgaatc gataacagcg tacccatatt cgtgatcagc agatacatca gcatggtcgc
    21301 tacagtagac gggatgccgg caatcgctac aatctctttt gggaaaaacg tccaataccc
    21361 gatcaggaac agaatggcgc taataaatac cgaaggaatc caagccttcg tacgcaccga
    21421 taccgcgtca cctacaaaca aaatgaaaac caccagtacc agagccaata actgtgacat
    21481 tccattccct ccctgttgtg ctgttgtcta aaactgctat gtatgttgcc cgtttcttcg
    21541 atgtacagat ccgtgcgatt gcctcctttg ctgtgttttg ggcaatatta attgttgaat
    21601 atagtacagt tcactggatc agtcaaccga attaatgctt taaaaggata aaacaataaa
    21661 aagccgatgc gacggttttg ttttccgttg catcggtctg ttgttagcgg tgggcaatgt
    21721 tcgaacacag ctgtatcctt tttttcggtc atcggcagta cagcaaaccg attaatccat
    21781 attcaatacg ttagtctcgt aactctgaaa agcattctcc atgcccataa ttacatcttt
    21841 gatcttcata tagcctttgg tatacggctc ggaatcccgg atggcttccc acatataatg
    21901 gtactgctcc atgtccgctg tctcgcaaac tacaaagtcc gtataatctt tgcccggcag
    21961 cgcttcggcg tcaaaaaagc gtacctgtac cgcaggctca tgcttgcgga taatctcctg
    22021 caaaccggcc gcatgcatac gccgctcttc ccgcggaagt gccagccagg aagggtagaa
    22081 ttccaataat acaaccatca tataacgcat cgtttatctc tcctctatct cggttgttac
    22141 agcaagccat gtacagatca gccgctgtaa taggataggt acagtgtacg cccggcagga
    22201 acggttacac attaacaaag gttaatgaca agcaggcaaa tattcgcgtt cccgcttgat
    22261 ttatttttgt acatgcagct attcaaatga tgggttcgct ccgatcacag cgaatcacgg
    22321 cgaagtagcc gactgagtga tacgggagag accccgatat aagaagcgat atgatattgc
    22381 ggcactcgct tctccagacc cggatactta cgcaggcagg cctcatatcg ttcacgcgct
    22441 gaggcataca gcagctcccg ctccctttct tccttgcgga tatacagtcg ctcgacactg
    22501 acccggacga atcgttccca cgcatgactg ctgcgggtca gccgcttcaa cagatcgtaa
    22561 ggaatttcga tcactacaga gtcctccagt gcctcgatcg tataggcaga gggctgaccc
    22621 gtgatcatcg ctgcataaga ggtagcataa tcctgctcca tagtgaagcc agccgtatat
    22681 tcccgcccat cttccagtat ataatacagc cggaataatc cctgtataca gaaatgcgcg
    22741 ctattcacca gctgtccggc ttcaatcagc cgctggccgg aatggatagg ccggagcacc
    22801 gtctgctgga gaaaatgctc ccattcttct tccgttacgc cagcctgcgc cgccatctgg
    22861 tgtagaactt tatcattcgg ttgcattcat gcttctcctt tccttttatc aaaatctgca
    22921 ttctttatgt ttgattaatc gcattggatt gttgtgtttt ttatttcgct tttgatattt
    22981 acatagctta tttttttgtt tgtcacgact ggcagaatag ctttatttat ttcccgcata
    23041 cccattcctc tatacagtat accggccaag catgcttcat cgtcaatcct tggcgttcct
    23101 actctggcat gaataaatta gattcctaaa aaatctgtaa ttgggtatac ttaacatatt
    23161 gtaagcgtat acaataaatt tgtaacggta tctcctttct agttaccttt acgctgctgt
    23221 acctctattc acctattcaa aggaggaatt gtaatgagaa atgttcacgg taacaaaaca
    23281 ggctttttgc caaggctcgg cgcattatca ctatctgtga tgctgttctc cggtatggca
    23341 tccagtgccg gagcagccgg aagtgaccat gccgagtcta tcgccgctca aaaatctaca
    23401 acatctggcg tacaacagat tacgatcaac ggtcagcagc ggtatcagga aatcgatggt
    23461 ttcggcgcat ccggtgcctg gagtatcgac catatcggct cggaatggtc ggaaaagaac
    23521 aaaaataaag tcgccgatct attgttctcg caggataaag gaatcggact gtcgatctgg
    23581 cgcttcaata ttggagcggg tagcgtagat accgatcagg atattatcag cgatccatgg
    23641 cgccgggcgg agagcttcaa atccggcgaa gacaagccgt acgattggtc caaacaggct
    23701 ggccagcagt ggttcctgca ggctgccaaa aagcgcggcg ttgaagaaac cgtcgctttt
    23761 gtgaatagtc cgccggtatg gatgaccaag aacggtcacg gccagcccga tccatcggta
    23821 ggcagcacta atctcaagga agactatatt gacgattacg ctgttttcct cgcggatgta
    23881 ctggagcatt tccacaagca aaagctgggc ttcgactaca tcagcccgat caacgaaccg
    23941 acctgggact ggaaccgcgc cggacaggaa ggtaaccgct acaatatcga agatatcaaa
    24001 aaagtgctga tcgctctgga taaagaactg cacaaacgcg gcatcgacac cgaagtggat
    24061 gcgatcgaag ctgttgaata cctatccctg ctggataacg acatgtacgc tacatatacc
    24121 ggcaaagcag gcagtacgta tacgagcggt aatgccggcg gtgcctttga aggcaaatac
    24181 agtgaatata tcaaggaaat gctcggcgat ccgcaaattg ccggtatcat cggcaacaaa
    24241 atgagcgctc actcctactg gtccgacgaa gccaagccag gtgacgaccg tctggtgcgc
    24301 ctgcgcgagc tggtacggga aaacctcaat cggtatgtgc aggacgccaa gttctggatg
    24361 tccgaatact gtatcctcgg cgaccgcgga ccgggacgtg atctgacaat ggatactgcg
    24421 ctggatgtag ccaaagtcat tcactacgat atggtaacaa cccaggcatc cgcatggcag
    24481 tggtggctcg ccgtatccaa ggaagattac aaagatggcc tggtctatac cgattacaaa
    24541 aatcccggtg atacccagtc cattatcgaa tccaaaacac tctgggccct gggcaattac
    24601 agcaaattcg tccgtcccgg cgcacaacgc atcgatctac aaggcgccaa tgatccgaat
    24661 ggcctgatgg gatcggcata ttatcatgat ggagacaaac agctgtccgt cgtcttcgtc
    24721 aacagcagcg atgaagccaa aacgatccat ctggacgtca ccaacctgcc aggcggcaag
    24781 gacgtgaagc agttcaaacc gtatctgacc tctgaacacg ccgacctaaa aaagcagtcc
    24841 accgtctcgg tgaaaaaaga tattaccatt ccagctcgtt ccctgatgac actggtaggg
    24901 aaaaattaag cgctggatga cagacgtaca gggatgttta tagttaaaat aaagccagta
    24961 atctatttaa cattctctgc tggcgtatag atttacacta aacagacctg atccagccca
    25021 aaacaagtaa cagattgttt taattataga cagtgacctg ctgcggcatt attttggtta
    25081 ttcaaagcat gaagtccgat gatgctttta acacatatgc cagatgcggg tcactttctt
    25141 tttttgactg acaacacttc aaaacggccg tatatttgcg ctggtacgtg ttatcgccga
    25201 atcattgggc aagcctgtcg tatagaatgt agcgaatcat attgtagcaa tcaggagagc
    25261 agtgagtacc accaactaat agtgtaagaa gaaaaatact tatagtctaa tcaactactc
    25321 gtacaaagga gaatccagat catgaacaaa aagcatattt ccaccgtctt attaggctct
    25381 attctggctg gcagtctggt cgtggctcca cttggcgatt cggtctatgc agccgataca
    25441 tcgatccaga ttagaggtgc atatggcgta gttccatcgg atgtggctcc atatattcgg
    25501 aatggtgtaa cgatggttcc aatcaatgta gtaagcaaac taggaagcga taatacgtat
    25561 gtatcatgga ataataccag taaaacggta accataaatg ctgctggagc caaaacttta
    25621 ttacagcttg atcaaaaata tgctctgcaa aatggagccc ggatcgagtt ggcgcagcct
    25681 gccactttaa aagaaggggt cgttatggtt cctctgcgct ttgttggaga gtctattggt
    25741 gtgaaagtaa actgggatgc agcgaaccga attgtatata ttggtgaagc cagctcgtca
    25801 ccggttgatc ctgcggagac ttccgctgat tcggcccttc agatcctgtc caaacaaaga
    25861 gccaaagtga tatatgatct acccagaacc gaattgccaa cagaactgcc tacagtaggg
    25921 atgcagacgg taacccacta tttcccggta ggacaagcca atatattttt cgaagccatg
    25981 cctgatcgca tcagctatta tgaagtgaaa aataacaaag ccaaggaaat ttggtcagcc
    26041 aatcacaatg atcaaccctc tgccagcggc aaaggcttac cttttttgcc ataccaaatt
    26101 acaaaagaaa taggaaaaag accttccatt actgctacag tcgcctacta ccaatatagt
    26161 gcatccatat ccgatctacg ctatgggttg atcgatacca aaggaaatga cactgaactg
    26221 ggtcataccg atcctgcaca gatcaagcaa agattccctg tagatcaaaa agaacttgca
    26281 ttggtaaaat gatctattta gcagccaaaa aaaagcacag acaggtcgtt gtaacctgtc
    26341 tgtg
//
