LOCUS       NZ_BBZG01000001        26205 bp    DNA     linear   CON 12-AUG-2024
DEFINITION  Nonomuraea pusilla strain NBRC 110462, whole genome shotgun
            sequence.
ACCESSION   NZ_BBZG01000001
VERSION     NZ_BBZG01000001.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Nonomuraea pusilla
  ORGANISM  Nonomuraea pusilla
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1
  AUTHORS   Komaki,H., Ichikawa,N., Hosoyama,A., Fujita,N. and Igarashi,Y.
  TITLE     Draft Genome Sequence of Nonomuraea sp. TP-A0861, a Producer of
            Myxochelin A
  JOURNAL   Genome Announc 3 (6), e01430-15 (2015)
   PUBMED   26659677
  REMARK    DOI:10.1128/genomeA.01430-15 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3746196)
  AUTHORS   Hosoyama,A., Kimura,A., Ichikawa,N. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-AUG-2015) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, Biological
            Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.8
            Genome Coverage                   :: 107x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417755.1-RS_2024_08_12
            Annotation Date                   :: 08/12/2024 01:46:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,159
            CDSs (with protein)               :: 8,159
            Genes (RNA)                       :: 65
            rRNAs                             :: 1, 1 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 21 of 83
            Pseudo Genes (incomplete)         :: 72 of 83
            Pseudo Genes (internal stop)      :: 5 of 83
            Pseudo Genes (multiple problems)  :: 15 of 83
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:25:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1203423
            Orig. end                         :: 1229628
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBZG01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26205
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26205
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26205
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16205](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16205
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            356..805
                     /locus_tag="ASC57_RS05330"
     CDS             356..805
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017539879.1"
                     /locus_tag="ASC57_RS05330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_055501789.1"
                     /transl_table=11
                     /translation="MTSTSAQEQHLRDLARLRRVRDRIDREYAQPLDVEALARGVNMSA
                     GHLSREFRRAYGESPYSYLMTRRIERAMALLRRGDLSVTDVCFAVGCQSLGTFSTRFTE
                     LVGMPPSAYRRQAASAAAGIPSCVAKQVTRPVRNREAQVKQPRLA"
     gene            811..1221
                     /locus_tag="ASC57_RS05335"
     CDS             811..1221
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894118.1"
                     /locus_tag="ASC57_RS05335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_055503827.1"
                     /transl_table=11
                     /translation="MDMNIHSTFLPHDDPDASLAFYRDVLGFEVRNDVGYNGMRWITVG
                     PAEHPETSIVLYPPAASPGITDDERRTIAEMMAKGTYGIIVLATEDLDGVFDKLQAGDA
                     EVVQEPTEQPYGVRDCAFRDPSGNMVRIQQRR"
     misc_feature    1261..1270
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(1287..1302)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            1294..3684
                     /locus_tag="ASC57_RS05340"
     CDS             1294..3684
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894282.1"
                     /locus_tag="ASC57_RS05340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_055501790.1"
                     /transl_table=11
                     /translation="MSIATSQDAQRSAPHVADVHDVIRVHGARENNLKDVDVEIPKRRL
                     TVFTGVSGSGKSSLVFDTIAAESQRLINETYSAFVQGFMPTLARPEVDVLEGLTTAIIV
                     DQERMGANPRSTVGTVTDANAMLRILFSRLGQPHIGSPQAFSFNVASISGAGAVTLERD
                     GKTVSERRDFKITGGMCPRCEGMGSVTDLDLSQLYDDSKSLAEGAITVPGYKADGWMVR
                     SFTESGFLDPHKPIRDYTEQELHDFLHREPLKVKMKGINATYEGLIPRIQKSFLSKDVT
                     ALQPHIRAFVERAATFTACPDCGGTRLSAAARSSTIKGVSIADACAMQISDLAAWVRDL
                     DEPSVAPLLTALRHTLDSFVEIGLGYLSLDRSSGTLSGGEAQRTKMIRHLGSALTDVTY
                     VFDEPTVGLHPHDIQRMNDLLLRLRDKGNTVLVVEHKPEVIEIADHVVDLGPRAGAAGG
                     EVMFEGTVDALRASGTLTGRHLDDRASLKPSVRTPSGVLEVRGAATHNLQDVDVDIPLG
                     VLVVVTGVAGSGKSSLIHGSVSGRDGVVSVDQTPIRGSRRSNPATYTGLLDPIRKAFAK
                     ANGVKPALFSANSEGACPTCNGAGVIYTDLAIMAGVATPCEECDGKRFQASVLEYHLGG
                     RDISEVLAMSVTEAEEFFRSGEARTPAAHAVLDRLADVGLGYLSLGQPLTTLSGGERQR
                     LKLATQMADKGGVYVLDEPTTGLHLADVEQMLGLLDRLVDSGKSVIVIEHHQAVMAHAD
                     WIIDLGPGAGHDGGRIVFEGTPADLVAARSTLTGEHLAAYVGA"
     gene            3788..4390
                     /locus_tag="ASC57_RS05345"
     CDS             3788..4390
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891721.1"
                     /locus_tag="ASC57_RS05345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_055501791.1"
                     /transl_table=11
                     /translation="MTGTNGRRWNHNIHYHPRILDAVPAGARRALDVGCGEGTLARALR
                     RAVPHVTGIDLHAPSVEQAREHPGDVHYVVGDFLTHPFEPASFDVVASVATLHHMDAAT
                     GLARMRDLLRPGGVLAVVGLARSSMPRDLPRDLAAVAVSTLHRAVKGHWEHPSPTVWPP
                     PVTYPQMRALAAELLPGSEYRRHLLLRYSIVWRKPRD"
     gene            complement(4466..5029)
                     /locus_tag="ASC57_RS05350"
     CDS             complement(4466..5029)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595985.1"
                     /locus_tag="ASC57_RS05350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_055501792.1"
                     /transl_table=11
                     /translation="MPAIERLRPEEFAAHVEGLADVLADAVEGGASLGFVAPFDRVAAA
                     AWWRDQAPAVADGALIVWAARDAGGVAGTVSLALTTKPNGRHRAEVLKLIVHRRARGRG
                     LARALLAAAEGAAHEAGASLLLLDTESDSTAERLYVKEGWTRFGVVPGYASTPDGVLRD
                     CSFFYKRLGPRDGAHRSAAVAERA"
     misc_feature    complement(5004..5019)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(5141..5701)
                     /locus_tag="ASC57_RS42445"
     CDS             complement(5141..5701)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540350.1"
                     /locus_tag="ASC57_RS42445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_152992311.1"
                     /transl_table=11
                     /translation="MRDDLEVRLAERLAELRGEHGWSLDELAERSGVSRSTLSRLERGE
                     ISPTAAVLGRLGAAYGRTTSRLLAEVEAEPPQVVRAGEQRVWRDDETGFARRSVSPPHP
                     GLRGELVEGTLRPGADIAYDTPPVPGLEQHVWVLDGSVEITANGQAHELRAGDCLRFRL
                     WGSSRFRCPGPEPARYVLAVVLP"
     gene            complement(5731..6021)
                     /locus_tag="ASC57_RS42450"
     CDS             complement(5731..6021)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890242.1"
                     /locus_tag="ASC57_RS42450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6204 family protein"
                     /protein_id="WP_055501793.1"
                     /transl_table=11
                     /translation="MFRVVISGAFEELDDAGRAAVLAAGGAAFTEAGTFTHDGTLRSFT
                     FRCQVPAGPQDGEREATERALAALGAHRVPHRVLRVAVTDLRDIKIRRKRR"
     gene            complement(6021..6662)
                     /locus_tag="ASC57_RS05365"
     CDS             complement(6021..6662)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890241.1"
                     /locus_tag="ASC57_RS05365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_055501794.1"
                     /transl_table=11
                     /translation="MTEGLRERKKRQTRRRIADTAVRLFVERGFDQVTIAEVAAAADVS
                     VNTLYNYFPAKEDLVLPPEEASPTRLADIVRERPPGRSAAHAVLDRLRAEVRGRERIVG
                     LTEGFGRVLEMMRAAPTLTARLEDLAGQMTDALAETLAEETGAAPGDPLPRAVAWQLGC
                     CHSLVYAEIGRRTAAGEPPAAIAAAVLDLLDTVESLLGERLLTYAVRKDR"
     misc_feature    complement(6684..6698)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            7029..7883
                     /locus_tag="ASC57_RS05370"
     CDS             7029..7883
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038012.1"
                     /locus_tag="ASC57_RS05370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_082534678.1"
                     /transl_table=11
                     /translation="MVLAVCAAACNALSSVLQRRAARAASPDKDFSARLFLSLVRQPVW
                     IAAIGVLIVAFLLQAAALGLAGLTLVQPILVIELPFTLFIVRLMFKVRLRAREWTAILS
                     LTGGLALLLVATGAETGIESPDRAGWVAAALTTVLLVAALVAASRLGADGRRAALLGVA
                     SGLCFAFTAALMKDSVDVLTASPAAVLRTWQVYAMVAAGIAALYLLQNALHHGTLVVVQ
                     PSLTVTDPVASIGFGVALFGDTIRLGLWAVPELAGIALLFFGSLRLSQSPYVTYDGITR
                     PSR"
     gene            complement(7864..8943)
                     /locus_tag="ASC57_RS05375"
     CDS             complement(7864..8943)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633008.1"
                     /locus_tag="ASC57_RS05375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_055501795.1"
                     /transl_table=11
                     /translation="MPTRRAVLILSASMGAGHDAAAAELARRLTARGIDAEVADVLDLL
                     PLRFGPALRGWYGWTMRSAPWLYALVYRVFFAARHAPPASPLTSLAARRLLRLLRRRRP
                     DEVVSTFHLAAQAAGTLRRRGLLTARSTVLLTDFAAHRLWLHPGNDRYLCPDPATAQEV
                     RGVTGRPASCYAPLVRPAFLDVAPRGPGAGRRLVLVAAGSWGVGDVERTARVLARTGRY
                     RPVVLCGRNAALAARLRNAGVEGLGWHDDLPGLMGRAYALVDNAAGMTAREAMAAGLPV
                     VTYLPIPGHGRDGVLAMERAGVSLHARSAGGLVAALDRLEDGERERLRAAARALFAAPP
                     AEACFATGAGRRTLSGLGA"
     gene            8973..9788
                     /locus_tag="ASC57_RS05380"
     CDS             8973..9788
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540953.1"
                     /locus_tag="ASC57_RS05380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_055501796.1"
                     /transl_table=11
                     /translation="MTSLATSLVTRGNALGAVLGAAALGFAHAAPAATWLPPVRRLLPR
                     LSGVGTDGHVALTFDDGPDPRSTPRFLDELDRLGCRATFFVLGEMLERHRALGRRIVRD
                     GHELGVHGWRHRNALTVLPGRTAAELRRAAGLVAEVAGAAPVWYRPPYGVLSAEAVLAA
                     RRAGLRPVLWTAWGRDWTRSATPGSVLAALAPGLRGGATLLLHDSDCTSAPGSWRAALG
                     ALPAVVAACREAGLRVGPLRDHWPDVCQRRSPTFPTINRNFRNDDRVAL"
     gene            10001..10849
                     /gene="hpnC"
                     /locus_tag="ASC57_RS05385"
     CDS             10001..10849
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03464.1"
                     /locus_tag="ASC57_RS05385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_236714589.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-46,
                     bitscore: 157.2, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 1.8e-43, bitscore:
                     146.4, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVETRAREENFPVASRLLPRVHRSRLLAVYAFARWVDDVGDERP
                     RDEALRLLDTVEDDLRRLYEGDAPRLPVVRGLAPVVTACSIPVAPFLALVQANRLDQAV
                     SRYRTFDDLLAYCELSANPVGRIVLHVFGAATEEHLRLSDRICTALQIVEHCQDVAEDH
                     ARGRVYLPAEDLRRFGCSESDLRAASTPRRLRLAVALQVDRAERLLRAGEPLTASLTGL
                     ARVAVSGYVAGGQATVAALRRAGHDVLGRSVRPRRTVLAAAWLRLLARGGRHDHDVKEV
                     L"
     gene            10846..11769
                     /locus_tag="ASC57_RS05390"
     CDS             10846..11769
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634147.1"
                     /locus_tag="ASC57_RS05390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_236714590.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.9e-52, bitscore:
                     175.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 7.7e-63,
                     bitscore: 210.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAAEAYRHCEQVMRSRARNFSYGLRLLPGPKRRALSAVYAFAR
                     RIDDIADGAGTPHDRLAALAAARQTLEAAARAAHDGGDGGDGGADGHGGHGDGRPDLVL
                     VALRDAARRYPVPLAAFAELIDGCAADVRGTSYATLGELVGYCRCVAGSVGRLSLGVFG
                     TDDHETATPLADALGVALQLTNILRDLREDRLSGRVYLPAEDLARFGCTLDVDGHGRFT
                     DPPDRLAALVRFEAARARDWFAAGMRLLPMLDGRSAACTAAMAGIYRRLLERIVADPDA
                     ALTARLSLPGWEKAAVAARALAGAAR"
     gene            11766..13235
                     /gene="hpnE"
                     /locus_tag="ASC57_RS05395"
     CDS             11766..13235
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634146.1"
                     /locus_tag="ASC57_RS05395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_236714591.1"
                     /sec_met_domain="DAO (E-value: 1.6e-08, bitscore: 32.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPMNGPASGPMNGAASAPTGGRAPVVVVGGGLAGVAAAVALGE
                     AGHRVTLYEARPRLGGAAHSFHRGDLVVDNGQHVFLRCCTAYRGLLDRLGAPGDAPLQD
                     RFDISVLTPDGRRGRLRRLPLPGPLHLLPALAAYPLLSPADRLRAVRGSLALRRLDPAD
                     PALDRVDLAAWLSAHGQGEAAKDALWDLFAVAALNVRAQDAALGPAAMVFRTALLGRAG
                     AADIGVPAVPLGRLHHTAARAAVVRLGGDVRLSAKVTAVEPGPAVVVDGSRVEASAVIL
                     AVPHEQAARLLPASAAPEREAWSGLSASPIVNVHVVYDRRVTELPFAAAVGSPVQWVFD
                     KTRVAGVRGGQYLAVSVSAAGDWIDVPTARARETFLPALERLLPGARDARVVDFFVTRE
                     RRATFLQGPGSGALRPLAATRWPGLFLAGSWTATGWPDTMEGAVRSGLTAARLVRRHLS
                     GGRGHTSGEPARRPLRAYGAGRAWAAEEAVR"
     gene            13232..14254
                     /locus_tag="ASC57_RS05400"
     CDS             13232..14254
                     /EC_number="2.5.1.-"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634145.1"
                     /locus_tag="ASC57_RS05400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_055501798.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-57, bitscore:
                     192.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGRPGVIVPPPVTAARELVEPVLRAAVSRLDPVTARVAAYHLGW
                     ADADGRPAPSGGGKALRPALAVLSARAAAAADCLHAAAATELVHAFSLLHDDIMDGDAT
                     RRHRRAAWAVFGEPAAILAGDALLALAGELLLEDDCPGHARAARLLAVTVRDLIAGQAL
                     DLEFERRDDVTLDECLRMAAGKTGSLIACACSIGAVAVDGPVPLAGALSAFGAEVGLAF
                     QLADDLLGIWGAPAATGKPVLSDLRSRKKSLPIVAALTSGTRAGDRLAALLAAPGPLPE
                     ATLRQAAALVEEAGGRAWAEAEAKHRLDAAGRHLAAAGLPPAVHADLLDIARFLTSRGH
                     "
     gene            14256..16205
                     /gene="shc"
                     /locus_tag="ASC57_RS05405"
     CDS             14256..16205
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634144.1"
                     /locus_tag="ASC57_RS05405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_082534680.1"
                     /sec_met_domain="T2TS (E-value: 1.2e-148, bitscore: 493.6,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAAAPSSAALALDAACDHLLALQEPAGWWKGELQTNVTMDAED
                     LLLREFLGVRRPRDTEEAARWIRSQQRDDGTWATFHGGPGDVSTTVEAYAALRLAGDPA
                     DAAHMRAAARFVLDAGGIEASRVFTRIWLALFGQWSWRDLPVLPPEMMFLPPWFPLNVY
                     DWACWARQTIVPLTIVSAARPVRPLPFTLDELRTGRRVRRAPRGGWEAAFAALDRALHR
                     YERRPVPGLRRAAVRRAAEWIVARQERDGSWGGIQPPWVYSLIALRLCGYGLDHPVMRK
                     GLDGLERFIIRDEQGRRLEACQSPVWDTVLAINALRDAGLPPDHAALVKAAGWVLGEEI
                     RGPGDWSVRRPGLRPGGWAFEFDNDVYPDVDDTAEAVLALRRVDHPDVRPAVERAVTWM
                     AGMVSRDGGFAAFDADNTRTLCTRLPFCDFGAVIDPPSADVTAHTVEALVAEPPAPPAR
                     PDLVRRAVVWLLKAQEEDGSWFGRWGANHVYGTGAVVPALVAAGVRTDARCVRRAVAWL
                     ESHQNDDGGWGEDMRSYTDPSWIGRGASTPSQTAWALLALLAAGERSEAVERGVAWLVS
                     HQRPDGTWDEPFFTGTGFPGDFSINYHLYRLVFPISALGRYVAAVGATAQPHETAVAEQ
                     AGHREAGGTRTVAP"
     gene            16202..16885
                     /locus_tag="ASC57_RS05410"
     CDS             16202..16885
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013232.4"
                     /locus_tag="ASC57_RS05410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_063791953.1"
                     /transl_table=11
                     /translation="MSGLLVFTALGLEARALREGLPSMPGGAKVVRTGMGPRNAAAYAA
                     RALTASREPVAGRPGAVAVAGVGGALDRRLRPGDVVVASEVWWDGQTLPCPSARLLQAE
                     LARAGVPVVTGPLVTSGHLVSGAERGGLAARGALVVDMESGPVAAACAEAAPGGGLPFA
                     AVRIVVDTPDVPLLRPATLRGGARALRTLRRAGRPLARWALAQLITPAGADGAAGAHQE
                     EVRSI"
     gene            16882..17886
                     /gene="hpnH"
                     /locus_tag="ASC57_RS05415"
     CDS             16882..17886
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540959.1"
                     /locus_tag="ASC57_RS05415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_055501799.1"
                     /sec_met_domain="PF04055 (E-value: 1.2e-18, bitscore: 65.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.4e-08, bitscore: 30.9,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMPVRQALRIGGYILGQRVRGRAKFPLLLELEPLFACNLKCAGC
                     GKIQHPADVLKRRMPVEQAVAAVEECGAPMVSIAGGEPLMHPEIGEMVRRLVAMKRYVF
                     LCTNALLIPKKIDQFEPSPYFAWTVHIDGLRERHDASVCKEGVFDQAVEAVRECRRRGF
                     RVTTNTTFFNTDSPQTVIDVLDYLNDDLRVDEMMISPGYAYEKAPDQEHFLGVQETRAL
                     FRKAFSGGNRRRWRFNHTPLFLDFLEGRADFACTAWAIPSYSLFGWQRPCYLMADGYAA
                     SYRELVEDTDWDSYGRGRDPRCANCMAHCGYEPTAVFATLSSLKESLRAIRGG"
     gene            18043..19548
                     /locus_tag="ASC57_RS05420"
     CDS             18043..19548
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892278.1"
                     /locus_tag="ASC57_RS05420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_055501800.1"
                     /transl_table=11
                     /translation="MNADVIVVGAGPTGLLLAAELGLAGVRAVVVERLARRSGQSKALG
                     IQPRSAEALDLRGLLEPLMDRAIQRVDGGHFAGLRLDYTAWNTRHPYSIGIPQGRVEAL
                     LEERLGELDVQVLRGHEVTALSQDADGVEATLLGPGGESRLTARFLVGCDGGRSTVRRL
                     LGIGFPGLDGKLLSVVADITISDPDGAVPETWTLPVMTPDKTGKGYIAPIGDGVHRFLF
                     YGAEQQRLSRDAPITEEEVRRALQHEFGPGVRLTGVRWASRFTDASRQVERYRHGRILL
                     AGDAAHIHSPSGGQGLNLGLQDAFNLGWKLAAEIAGWAHDGLLDTYHSERHPVAARVLA
                     NTRAQAVLLVHDEENLALRGIMEELLRVPEANRIVAGMISGLDIRHDLPGRPHHLLGRH
                     VPNLDLVTASGPERVARLLRDGRGLLLTTADEATFAKAAEPWSARIGRAHAQAELGADA
                     VLVRPDGYVCWAGSVADVSGLADALARWAGAPARPSSPVTTPE"
     gene            complement(19579..20319)
                     /locus_tag="ASC57_RS05425"
     CDS             complement(19579..20319)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073966.1"
                     /locus_tag="ASC57_RS05425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_055501801.1"
                     /transl_table=11
                     /translation="MTIPLTTGTPATGTPGPYSVGLAVSPADVRAAQRLRYRVFAEEMG
                     ARLDSPVSGLDVDRFDAYCDHLLVRCGDEVVGTYRLLPPGRADRLCSDGRFDLGNLTAI
                     RKDLVEVGRACVHPGHRSGAVVALMWAGIARYMVDGGHRWLAGCCSVPLDDGGAVAAGV
                     VEMVPQGPEEHRVRPYEPWRGGAAPRPDRFVLPPLLRGYLRLGAWVCGAPAHDRDFGTA
                     DFFVLLSMDQAGTRDLRHFLGEPL"
     gene            complement(20440..21162)
                     /locus_tag="ASC57_RS05430"
     CDS             complement(20440..21162)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-153). E-value: 4.7e-12. Score:
                     38.1. Matches aSDomain:
                     nrpspksdomains_ASC57_RS05430_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540960.1"
                     /locus_tag="ASC57_RS05430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_236714592.1"
                     /transl_table=11
                     /translation="MLVTGASSGIGAATARAMAASGARLLLTGRDPGRLAAVAAEVGGE
                     ALTADLVTEAAALARWAGPVDVLVSGAGAGWAGPVAAMPDGAAAHLIAANLTAPVELTR
                     LLLPAMIERGRGHLVYVSSIAGAVGVRDEAVYSSAKAGLIAFAESLRYELDGIGVSVVL
                     PGVVDTPFFARRGVPYARRRPAPIPAERVARAVVAAVERGRAETYTPGWLRFPARLRGA
                     APGPFRALACVFGGSGRR"
     aSDomain        complement(20704..21159)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ASC57_RS05430_PKS_KR.1"
                     /evalue="4.70E-12"
                     /label="ASC57_RS05430_PKS_KR.1"
                     /locus_tag="ASC57_RS05430"
                     /protein_end="153"
                     /protein_start="1"
                     /score="38.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVTGASSGIGAATARAMAASGARLLLTGRDPGRLAAVAAEVGGEA
                     LTADLVTEAAALARWAGPVDVLVSGAGAGWAGPVAAMPDGAAAHLIAANLTAPVELTRL
                     LLPAMIERGRGHLVYVSSIAGAVGVRDEAVYSSAKAGLIAFAESLRYE"
     CDS_motif       complement(21073..21159)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ASC57_RS05430_0001"
                     /evalue="1.20E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="ASC57_RS05430"
                     /protein_end="30"
                     /protein_start="1"
                     /score="24.3"
                     /tool="antismash"
                     /translation="LVTGASSGIGAATARAMAASGARLLLTGR"
     gene            complement(21293..22609)
                     /locus_tag="ASC57_RS42455"
     CDS             complement(21293..22609)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASC57_RS42455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_055501803.1"
                     /transl_table=11
                     /translation="MRRRSAGTPAARPLPRPGAAAPGKVRAAVAVLIAACVAVSACGAG
                     SPRRGGASPAASPSVSTAASTPGPLATTTAPALVTTPANCPVTSRHDDGFRAATASSGW
                     ELAWLDDAPEETSLRAGAATADGALWALFVRASGAIEPRRWHGGAWRAPPSAPSSQEVR
                     ALGAASADRAWVVVTADGAPALTVWDGTAWRATPLGLGAYTGAGPVAAGPWLALSTGST
                     RWDGAAWRSAPLPLHVNALTGPGDEPWAIGFADPMDPDASSALARWTGAAWQSVPVPAL
                     GLPPDAEPVHADQGRTVVKSVVRTGPQEWWALGSFQWMEHEHMDGEDIFPGRSVALRLA
                     GGTWTCVVGASWPDGWKGFTAAASDGRGGLWAVSVPDELWHLSEGRWTRERPPVRRGGR
                     ASVEDLVARPGTGELYALGSIGTQPYGEDSRAALWRLRP"
     gene            complement(22625..23035)
                     /locus_tag="ASC57_RS05440"
     CDS             complement(22625..23035)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ASC57_RS05440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="sensor histidine kinase"
                     /protein_id="WP_055501804.1"
                     /transl_table=11
                     /translation="MTGTKKITPPACALAQELETYAGQWSERTGIALETWALPAADVPE
                     RVTRGVLAVLHEALANVERHSGASSVSLAVTVGKSGLRMTISDNGAGYTSADSGSGFTA
                     MRDAFAAIGGNLSIHSVPREGTTISGTVSDLR"
     gene            23444..25591
                     /gene="helR"
                     /locus_tag="ASC57_RS05445"
     CDS             23444..25591
                     /codon_start=1
                     /gene="helR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891693.1"
                     /locus_tag="ASC57_RS05445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase recycling motor ATPase HelR"
                     /protein_id="WP_055501805.1"
                     /transl_table=11
                     /translation="MNPLTTSAFDLPERLSPKADPALIAGDEGHFTAVAESLEQTITEL
                     SARLDAERRAPGGAGRQALERDLEIHRLSGRLRALRRFGLDLCLGRMVLADDPEPVYVG
                     RLGLTDGAGRRLLLDWRSPAAEPFFGATHANPMGLASRRRYRWTRGRISDYWDEVFTPD
                     GFEGHAALDDQSAFIATLGGSRSPRMRDVLATIQADQDAVIRAGSRGALVVDGGPGTGK
                     TVVALHRSAYLLYSDPRVGRGRGGVLFVGPHQPYLAYVADVLPSLGEEGVRTCTLRDLV
                     QEGATAATETDPDVARLKGSADLVKAIEPAVRFYENPPAEGMTVTTPWSDVWLSADDWA
                     EAFEAPEPGTPHNEARDRILDELVAILRDKHDEDVPADLLRTSLLRDRELLTALNRAWP
                     LIEAADLVGDLWSVPAYLRMCAPWLGPDDVRKLQRADAQAWTVSDLPLLDAARRRLGDP
                     EASRARRRREASLAAQREDMTRVVDNLLQADDDGEGLVTMLRGQDLRDSLVDETALPAA
                     DPDLLAGPFAHLVVDEAQELTDAEWQMLLHRCPSRSFTIVGDRAQARHGFTESWQERLE
                     RIGLDRITLASLTINYRTPEEIMAEAEPVIRAVLPDANVPTSIRRGGVPVAHRPASDLD
                     AVLDAWLSEHADGVACVIGDPTFRPTSRVRSLTPELSKGLEFDLVVLVDPEAFGDGVEG
                     AVDRYVAMTRATQRLVILTSS"
ORIGIN
        1 ctggtcgtcg cgtacgactt ccgccgctac tcccccggca ccgcccggtt cgtcctggcg
       61 gcgcgcgagc ggggcgcccg cctggtgctc gtcaccgacg cctgggagtc cccgctggcg
      121 ccggaggcgc acgcgctggt gcggctgccg cgcgaggccg ccgggccgat cgcgccgctc
      181 acccacgaga tcgccgtgac cgagctgctg ctcgtcgcca cggcgtcccg cctggccccc
      241 gccgcccgcc tggccgacct cgacgcgctc acccacgccc tgacccggcc cgagtagggc
      301 tcccgccgcc ctcgccggag aaccccggcg gctcccggcg acgtacgatg ccgaggtgac
      361 cagcacatct gcccaggaac agcacctgcg cgacctcgca cggctgcgcc gcgtccgcga
      421 caggatcgac cgcgagtacg cgcagccgct ggacgtcgag gcgctcgccc gcggggtgaa
      481 catgtcggcc ggccacctca gccgggagtt ccggcgcgcc tacggcgagt ccccgtactc
      541 ctacctcatg acccggcgca tcgagcgcgc catggcgctg ctgcgccgcg gcgacctcag
      601 cgtcaccgac gtctgcttcg ccgtcggctg ccagtcgctc ggcacgttca gcacccgctt
      661 caccgaactg gtcggcatgc cgcccagcgc ctaccggcgg caggccgcga gcgccgcggc
      721 gggcatcccc tcgtgcgtcg ccaagcaggt gacccgaccg gtcaggaatc gagaagcgca
      781 ggtcaagcag ccccggctag cgtgaacgcc atggacatga acattcactc caccttcctc
      841 ccgcacgacg accccgacgc ctccctcgcc ttctaccgcg acgtcctcgg cttcgaggtc
      901 cgcaacgacg tcggctacaa cggcatgcgc tggatcacgg tcggccccgc cgagcacccc
      961 gagacgtcga tcgtcctgta cccgccggcg gccagccccg gcatcaccga cgacgagcgc
     1021 cgcaccatcg ccgagatgat ggccaagggc acctacggca tcatcgtcct cgccaccgag
     1081 gacctcgacg gcgtcttcga caagctgcag gccggcgacg ccgaggtcgt ccaggagccg
     1141 accgagcagc cgtacggcgt ccgcgactgc gccttccgcg atccgtccgg caacatggtg
     1201 cgcatccagc agcggcgctg agcagccgtc cggtccaccg ctgcccaccc cgcttcggcc
     1261 gaaggcggcc ctcccccatc gatggagaca cagatgagca ttgccacgag ccaggacgcg
     1321 cagcggtccg cgccgcacgt cgccgacgtc cacgatgtga tccgcgtgca cggcgcgcgc
     1381 gagaacaacc tcaaggacgt cgacgtcgag atccccaagc gccggctgac ggtgttcacc
     1441 ggcgtgtccg gctcgggcaa gagctcgctg gtgttcgaca cgatcgccgc cgagtcgcag
     1501 cggctgatca acgagaccta cagcgccttc gtgcagggtt tcatgccgac gctggcgcgg
     1561 cccgaggtcg acgtgctcga agggctgacc acggcgatca tcgtcgacca ggagcggatg
     1621 ggcgccaacc cccgctccac ggtcggcacc gtcaccgacg ccaacgcgat gctgcgcatc
     1681 ctgttcagcc gcctggggca gccgcacatc ggctcgcccc aggcgttctc cttcaacgtc
     1741 gcctccatca gcggggcggg ggcggtcacg ctggagcgcg acgggaagac cgtgagcgag
     1801 cggcgcgact tcaagatcac cggcggcatg tgcccgcgct gcgagggcat gggctcggtc
     1861 accgacctcg acctgtccca gctgtacgac gactccaagt cgctcgccga aggcgcgatc
     1921 accgtccccg gctacaaggc ggacggctgg atggtgcggt cgttcactga gtccggcttc
     1981 ctcgaccccc acaagccgat ccgcgactac accgagcagg aactgcacga cttcctccac
     2041 agggaaccgc tcaaggtcaa gatgaagggg atcaacgcca cgtacgaggg cctgatccca
     2101 cggatccaga agtcgttcct gtccaaggac gtcaccgcgc tgcagccgca catccgcgcc
     2161 ttcgtcgagc gggccgccac cttcaccgcc tgccccgact gcggcggcac gcggctgagc
     2221 gccgcggcca ggtcctccac gatcaagggg gtcagcatcg ccgacgcctg cgcgatgcag
     2281 atcagcgacc tggccgcgtg ggtgcgcgac ctcgacgagc cgtcggtggc gccgctgctc
     2341 acggcgctgc ggcacacgct cgactcgttc gtggagatcg gcctcggcta cctcagcctc
     2401 gaccggtcgt cgggcaccct gtcgggcggc gaggcgcagc gcaccaagat gatccgccac
     2461 ctcgggtcgg ccctcaccga cgtgacgtac gtgttcgacg agcccaccgt cgggctgcac
     2521 ccgcacgaca tccagcgcat gaacgacctg ctgctgcggc tgcgcgacaa gggcaacacg
     2581 gtgctggtcg tcgagcacaa gccggaggtc atcgagatcg ccgaccacgt cgtcgacctc
     2641 gggccccgcg ccggcgccgc cggtggcgag gtgatgttcg agggcaccgt cgacgcgctg
     2701 cgcgccagcg gcacgctgac cgggcggcac ctcgacgacc gggcctccct gaagccgtcg
     2761 gtgcgcacgc cgtcgggagt gctggaggtg cgcggcgccg ccacccacaa cctccaggac
     2821 gtcgacgtcg acatcccgct cggcgtgctg gtggtcgtga ccggcgtggc agggtcgggc
     2881 aagagctccc tgatccacgg ctcggtctcg ggcagggacg gcgtggtgtc ggtcgaccag
     2941 accccgatcc gcggctcccg gcgcagcaac ccggcgacgt acacggggct gctcgacccg
     3001 atccgcaagg cgttcgcgaa ggccaacggc gtgaagccgg cgctgttcag cgccaactcc
     3061 gagggcgcct gccccacctg caacggcgcc ggcgtcatct acaccgacct cgccatcatg
     3121 gcgggcgtcg ccaccccctg cgaggagtgc gacgggaaga ggttccaggc gtcggtgctg
     3181 gagtaccacc tcggcggccg tgacatcagc gaggtgctcg cgatgtcggt gaccgaggcc
     3241 gaggagttct tccgctccgg agaggcccgc acgcccgccg cccacgccgt cctcgaccgg
     3301 ctcgccgacg tcgggctcgg ctacctcagc ctcggccagc cgctcaccac gctgtcgggc
     3361 ggcgagcggc agcggctcaa gctcgccacc cagatggccg acaagggcgg cgtctacgtc
     3421 ctcgacgagc ccaccaccgg cctccacctg gccgacgtcg agcagatgct cggcctgctc
     3481 gaccggctcg tcgactccgg caagtcggtc atcgtgatcg agcaccacca ggccgtcatg
     3541 gcgcacgccg actggatcat cgacctcggc cccggggccg ggcacgacgg cggccggatc
     3601 gtcttcgagg gcacgcccgc cgacctcgtc gccgcccgct ccaccctcac cggcgagcac
     3661 ctcgcggcct acgtcggcgc ctgaccccgc acccgggcgg gggcgggccc caccacaggc
     3721 tcgctgccgc ccccgggccc ggcccgattc cgggacggcc ccggccccgg tgcggcagga
     3781 tgatcacatg acagggacga acggcaggcg gtggaaccac aacatccact accacccccg
     3841 gatcctggac gcggttcccg cgggcgcccg gcgcgccctc gacgtcggct gcggcgaggg
     3901 cacgctcgcc cgcgcgctgc ggcgggccgt gccgcacgtc accggcatcg acctccacgc
     3961 gcccagcgtc gagcaggccc gcgagcaccc cggcgacgtc cactacgtcg tcggcgactt
     4021 cctcacccac cccttcgagc ccgcctcgtt cgacgtcgtc gcgtcggtgg ccaccctgca
     4081 ccacatggac gccgccaccg gcctggcccg gatgcgcgac ctgctgcgtc cgggcggcgt
     4141 cctggccgtc gtcggcctcg cccgcagcag catgccgcgc gacctgccgc gcgacctcgc
     4201 ggccgtcgcc gtcagcaccc tccaccgggc cgtcaagggc cactgggagc acccgtcccc
     4261 caccgtgtgg ccgccgccgg tgacgtaccc gcagatgcgg gcgctcgccg ccgaactgct
     4321 gcccggctcc gagtaccgcc gccacctcct gctgcggtac agcatcgtct ggcgcaagcc
     4381 gcgcgactga gcgccgccgc gatcgacggc gcgatccggg ccctgcgctc cccgccgtcc
     4441 tcctgaccgc cggctccaga gccggtcagg cccgctccgc caccgccgcg ctccggtgcg
     4501 cgccatcgcg cgggccgaga cgcttgtaga agaagctgca gtcgcgcagg acgccgtcgg
     4561 gggtcgaggc gtagccgggg acgacgccga agcgcgtcca gccctccttg acgtagaggc
     4621 gttccgccgt gctgtccgac tcggtgtcga gaaggagcag gctcgccccc gcctcgtgcg
     4681 ccgcgccctc cgcggcggcc agaagggcgc gggccagccc gcggccccgg gccctgcggt
     4741 ggacgatcag tttgagcacc tcggcgcggt ggcgcccgtt gggcttggtg gtcagggcca
     4801 ggctgacggt gcccgccacg cccccggcgt cgcgggcggc ccagacgatc agcgcgccgt
     4861 cggccacggc gggggcctgg tcgcgccacc acgccgccgc ggcgacccgg tcgaacggcg
     4921 ccacgaagcc gagcgacgcc cctccttcca cggcgtcggc caggacgtcg gcgagcccct
     4981 cgacgtgggc ggcgaactcc tcggggcgca gacgttcgat ggcgggcacg ggacgcactc
     5041 ctcggctggc acgaatcagg acaggacggt tggggggggc ggtaaggctc gtgcggtttc
     5101 ggggcgggag ggttcgcagt cgctcggtcg gcctgctcgg tcatggcagg acgacggcca
     5161 ggacgtagcg ggccggttcc ggccccgggc agcggaacct ggagcttccc cacagccgga
     5221 accgcaggca gtcgccggcc cgcagctcgt gcgcctgacc gttcgcggtg atctcgacgc
     5281 tgccgtcgag gacccagacg tgctgttcga gcccgggcac gggcggcgtg tcgtacgcga
     5341 tgtcggcgcc cggccgcagc gtgccctcga ccagctcgcc ccgcagaccg gggtgcggcg
     5401 gggagaccga ccggcgcgcg aagccggtct cgtcgtcgcg ccagacccgc tgctcgccgg
     5461 cccgtacgac ctgtggcggc tccgcctcga cctcggcgag caggcgtgag gtggtgcgcc
     5521 cgtaggcggc gccgagccgg ccgagcacgg ccgcggtggg gctgatctcg ccgcgttcca
     5581 ggcgcgacag cgtcgaacgg ctcacgccgg aacgctccgc gagctcgtcg agcgaccagc
     5641 cgtgctcgcc gcgcagctcc gccagccgct cggccagccg aacctccaag tcatctctca
     5701 catccgggaa tctatcccag attcgggaga ctagcgccgc ttgcgacgga tcttgatgtc
     5761 gcgcaggtcc gtcacggcga cacgcaggac ccggtgcggc acccggtggg ccccgagtgc
     5821 ggcgagcgcc cgctcggtcg cctcgcgctc gccgtcctgc ggcccggcgg gcacctggca
     5881 gcggaacgtg aacgaccgca gggtgccgtc gtgcgtgaac gtgcccgcct cggtgaacgc
     5941 ggcgccgccc gccgccagca cggccgcccg cccggcgtcg tccagctcct cgaacgcgcc
     6001 ggagatcact accctgaaca tcatcggtcc ttccgtacgg cataggtcag caggcgctcg
     6061 cccagcaggc tctccaccgt gtcgagcagg tcgagcacgg ccgcggcgat cgcggcgggc
     6121 ggctcgcccg cggcggtgcg cctgccgatc tcggcgtaga cgagcgagtg acagcagccg
     6181 agctgccagg ccaccgccct gggcaggggg tcgccgggcg ccgccccggt ctcctcggcg
     6241 agcgtttcgg cgagggcgtc ggtcatctgc ccggccaggt cctccagccg ggcggtcagg
     6301 gtgggcgcgg cgcgcatcat ctccagcacc cgtccgaacc cctcggtgag ccccacgatc
     6361 cgctcccggc cgcgcacctc ggcgcgcagc ctgtcgagca cggcgtgggc cgcggaccgg
     6421 ccgggcggac gctcgcgcac gatgtcggcc agccgggtgg gcgacgcctc ctcgggcggc
     6481 aggacgaggt cctccttggc ggggaagtag ttgtagagcg tgttgaccga cacgtcggcg
     6541 gcggccgcca cctcggcgat cgtgacctgg tcgaatccgc gctccacgaa caggcgcacg
     6601 gcggtgtcgg cgatgcgccg ccgtgtctgc cgcttcttgc gctcccgcag cccctccgtc
     6661 atggccaaag gttaactgga atccaaaatt gaagtccact gcatttttgt ggcggccgcc
     6721 gtcggcgccc ttctcggaag cgcaaaggac gtccctgatc tgcgcagcga gcggcgtgga
     6781 gggccgccgg gacacgcccg gttcgcccat gctcgtgctg ccggtcgtcg cggggacgcc
     6841 cggccagagc agcggaaggg gtcgtgcatg ccggccgacg tcctcccagg cccgctcggg
     6901 cggggccgcc gggcgccgcg cgccccgcgc cgggccggcg acggcacgca cgacctgccc
     6961 gggacgcggg gcctgcctgg cgggcgcgtg cggcggaagg ccggtgggcg ctgagcaccg
     7021 ccgtcgcggt ggtgctggcc gtgtgcgccg ccgcctgcaa cgccctgtcc tcggtgctgc
     7081 agcgccgcgc cgcccgcgcc gcctcgcccg acaaggactt ctcggcacgg ctgttcctga
     7141 gcctggtcag gcagccggtg tggatcgccg ccatcggcgt gctcatcgtg gcgttcctgc
     7201 tgcaggccgc ggcgctcggg ctcgcggggc tgacgctcgt gcagcccatc ctcgtcatcg
     7261 agctgccgtt cacgctcttc atcgtccgcc tgatgttcaa ggtcaggctc agggcgcggg
     7321 agtggacggc catcctcagc ctgaccggcg ggctggccct cctgctcgtc gccaccggcg
     7381 cggagacggg catcgagtcg cccgaccgcg ccggctgggt ggcggccgcg ctcacgacgg
     7441 tcctgctcgt ggccgctctc gtcgccgcgt cccggctggg cgcggacggc cggcgcgcgg
     7501 cgctgctcgg ggtggcgtcc ggcctgtgct tcgccttcac cgccgcgctc atgaaggaca
     7561 gcgtggacgt gctcaccgcg agccccgccg ccgtcctgcg cacctggcag gtgtacgcca
     7621 tggtggccgc cggcatcgcc gcgctgtacc tgctgcagaa cgccctgcac cacggcaccc
     7681 tggtggtcgt ccagccgtcg ctgaccgtga ccgacccggt ggccagcatc ggcttcggcg
     7741 tcgcgctgtt cggcgacacg atcaggctcg gcctgtgggc ggtgcccgag ctggccggga
     7801 tcgcgctgct gttcttcggc agcctcaggc tctcccagtc gccgtacgtc acctatgacg
     7861 ggatcacgcg cccaagccgc tgagcgtccg gcgcccggcg ccggtcgcga agcacgcctc
     7921 cgcgggcggg gccgcgaaca gcgcgcgggc cgcggcgcgc aggcgctccc gctcgccgtc
     7981 ctccagccgg tcgagcgcgg cgaccagccc gcccgccgag cgggcgtgca ggctcacgcc
     8041 cgcccgctcc atcgccagca cgccgtccct gccgtgcccc gggatcggca ggtacgtgac
     8101 gacgggcagc cccgcagcca tcgcctccct ggccgtcatc ccggccgcgt tgtcgaccag
     8161 cgcgtacgcc cgccccatga gccccggcag gtcgtcgtgc cagccgagcc cctccacgcc
     8221 ggcgttccgc agccgcgcgg ccagcgcggc gttacgcccg cacaggacga ccgggcggta
     8281 ccggccggtc cgcgcgagga cgcgggcggt ccgctccacg tcccccacgc cccacgaccc
     8341 ggccgccacc agcaccaggc gccggcccgc gccggggccg cgcggggcga cgtccaggaa
     8401 cgcggggcgg accagcggcg cgtagcagga cgcggggcgg ccggtgacgc cgcgcacctc
     8461 ctgcgcggtg gccgggtcgg ggcacaggta gcggtcgttg cccgggtgca gccagagccg
     8521 gtgcgccgcg aagtccgtca gcagcaccgt gctgcgggcc gtgagcaggc cgcgccgccg
     8581 cagcgtgccg gccgcctggg cggcgaggtg gaaggtggag acgacctcgt ccgggcgccg
     8641 gcgccgcagc agccgcagca gccgccgggc ggccagcgac gtcaggggcg aggccggcgg
     8701 cgcgtggcgc gcggcgaaga agacccggta caccagcgcg tacagccagg gcgccgagcg
     8761 catcgtccag ccgtaccagc cgcgcagggc cgggccgaac cgcagcggga gcaggtcgag
     8821 gacgtcggcg acctcggcgt cgatccccct ggcggtcagc cgcctggcca gctcggcggc
     8881 ggcggcgtcg tggccggcgc ccatgctcgc gctcaggatc agcaccgcgc gccgcgttgg
     8941 catggccgcc cctctctccc agactgggcc gcatgaccag cctcgcgacc agccttgtta
     9001 ccaggggaaa cgcgttgggg gcggtgctgg gggcggccgc gctggggttc gcgcacgccg
     9061 cccccgccgc gacgtggctg ccgcccgtca ggcggctgct gccccgcctg tccggcgtcg
     9121 ggacggacgg gcacgtcgcc ctcaccttcg acgacgggcc cgacccgcgc tcgaccccgc
     9181 gcttcctgga cgagctggac cgcctgggct gccgggcgac gttcttcgtc ctcggggaga
     9241 tgctggagcg gcaccgggcg ctcggccgcc gcatcgtacg ggacgggcac gagctgggcg
     9301 tgcacggctg gcggcaccgc aacgcgctga cggtcctccc gggcaggacg gccgccgagc
     9361 tgcggcgcgc ggcgggactc gtggccgagg tggcgggcgc cgctcccgtc tggtaccggc
     9421 cgccgtacgg ggtgctgagc gcggaggcgg tgctcgccgc ccggcgggcc gggctgcggc
     9481 cggtgctgtg gacggcctgg gggcgggact ggacgcggtc ggccaccccc ggctcggtgc
     9541 tggctgcgct ggcgcccggg ctgcgcggcg gggcgaccct gctgctgcac gactccgact
     9601 gcacctccgc gcccggctcg tggcgcgccg cgctcggggc cctgccggcg gtcgtggccg
     9661 cctgccggga ggccgggctg cgggtggggc cgctgcgcga ccactggccg gacgtgtgcc
     9721 aacgccgctc ccccactttc ccaacaatta accgaaattt ccggaacgac gacagggttg
     9781 ccctttaaag acatttaccg gcctttttcg gtcggccggg tttcgccttt ccgacagcgc
     9841 gacggatgac ccggacgtcg gctccgaaca gcacttattc cgaatctcaa tattcactca
     9901 gcaggcgccc gttaaacacc catgaggcgg cgtgtgcgcg tttatggacg cgtgcaacgg
     9961 agagccttgg atgcatgccg aaacgggccg gacggcgcat atgaccgtcg agacgagggc
    10021 gcgcgaggag aatttccccg tcgcttcccg gctgctgccc cgggtccacc gcagccgtct
    10081 gctcgccgtg tacgccttcg cccgctgggt ggacgacgtc ggtgacgaac gaccgcgcga
    10141 cgaggcgctg cgcctgctcg acaccgtcga ggacgacctg cgccgcctct acgaggggga
    10201 cgccccccgc ctgccggtcg tccgcgggct ggcgcccgtc gtcaccgcct gctccatccc
    10261 ggtcgcgccg ttcctcgccc tcgtccaggc caaccggctc gaccaggccg tcagccggta
    10321 ccgcaccttc gacgacctgc tcgcgtactg cgagctgtcg gcgaacccgg tgggccgcat
    10381 cgtgctgcac gtgttcggcg cggccaccga ggagcacctg cggctgtccg accggatctg
    10441 cacggcgctg cagatcgtcg agcactgcca ggacgtcgcc gaggaccacg cgcgcggccg
    10501 cgtctacctg ccggcagagg acctgcggcg gttcggctgc tccgagtccg acctgcgcgc
    10561 ggcgagcacg ccgcggcgcc tgcgcctcgc cgtcgccctg caggtggaca gggccgagcg
    10621 gctgctgcgt gcgggggagc cgctcaccgc gtcgctgacc ggcctcgccc gcgtcgccgt
    10681 ctccggctac gtcgcgggcg gccaggccac ggtcgccgcc ctgcggcggg ccgggcacga
    10741 cgtcctcggc cggtccgtcc ggccgcgcag gaccgtgctg gcggcggcgt ggctgcgcct
    10801 cctggcgcgg ggcggacgcc atgaccacga cgtgaaggag gtcctgtgac aggcgcggct
    10861 gaggcgtacc ggcactgcga gcaggtgatg cgcagccggg cgcgcaactt ctcctacggc
    10921 ctgcggctgc tgcccggccc gaagcgcagg gcgctgagcg ccgtgtacgc cttcgcccgc
    10981 cgcatcgacg acatcgccga cggcgcggga acgccgcacg accggctggc cgcgctggcc
    11041 gccgccaggc agacgttgga ggccgccgcg cgggccgccc acgacggcgg tgacggcggc
    11101 gacggcggcg ccgatggcca cggcggccac ggggacgggc ggccggacct cgtgctggtg
    11161 gcgctgcgcg acgccgccag gcgctacccg gtgccgctcg ccgcgttcgc cgagctcatc
    11221 gacggctgcg ccgccgacgt gcgcggcacc tcgtacgcca ccctgggcga gctcgtgggc
    11281 tactgccggt gcgtggccgg ctcggtcggc cggctgtcgc tcggcgtgtt cggcacggac
    11341 gaccacgaga ccgccacgcc cctcgccgac gcgctcggcg tggcgctcca gctcaccaac
    11401 atcctcaggg acctcaggga ggaccgcctg tcaggccgcg tctacctgcc ggccgaggac
    11461 ctcgcgaggt tcggctgcac cctggacgtc gacgggcacg gccggttcac cgacccgccc
    11521 gaccggctgg ccgcgctcgt caggttcgag gcggcgcggg cccgcgactg gttcgcggcg
    11581 ggcatgaggc tgctgcccat gctcgacggc cgcagcgccg cctgcaccgc cgccatggcg
    11641 ggcatctacc ggcggctgct ggagcgcatc gtggccgacc cggacgccgc gctgaccgcc
    11701 aggctgtcgc tgcccggctg ggagaaggcc gccgtggccg cccgcgccct cgcgggagcg
    11761 gcccgatgac cggcccgatg aacggcccgg cgagcggccc gatgaacggc gcggcgagcg
    11821 cgccgacggg cgggcgggcc ccggtcgtgg tcgtcggggg cgggctggcc ggcgtggccg
    11881 ccgccgtggc gctcggcgag gccggccacc gcgtcaccct gtacgaggcc cgcccccgcc
    11941 tcggcggcgc cgcgcactcc ttccaccgcg gcgacctcgt ggtggacaac ggccagcacg
    12001 tcttcctgcg ctgctgcacc gcctaccggg gcctgctcga ccggctcggc gcgccgggcg
    12061 acgccccgct gcaggaccgc ttcgacatca gcgtgctcac ccccgacgga cgccggggcc
    12121 ggctgcgccg ccttccgctg cccgggccgc tgcacctcct gcccgcgctg gcggcgtacc
    12181 cgctgctgag cccggcggac cggctgcgcg cggtgcgcgg ctcgctcgcg ctgcgccgcc
    12241 tcgaccccgc cgaccccgcg ctcgaccgcg tggacctggc ggcctggctg tccgcgcacg
    12301 gccagggcga ggccgccaag gacgcgctgt gggacctgtt cgcggtggcc gcgctgaacg
    12361 tgcgcgcaca ggacgccgcg ctcggtcccg ccgcgatggt gttcaggacg gcgctgctcg
    12421 gccgggccgg cgccgccgac atcggcgtgc ccgccgtgcc gctcggccgg ctgcaccaca
    12481 cggcggcccg cgccgcggtc gtccggctcg gcggcgacgt gcggctgtcg gcgaaggtca
    12541 ccgccgtcga gcccggaccg gccgtcgtcg tggacggctc cagggtggag gcgtccgccg
    12601 tgatcctggc agtcccgcac gagcaggccg cccggctgct gcccgcgtcg gccgcgcccg
    12661 agcgggaggc gtggagcggc ctgtcggcca gccccatcgt caacgtccac gtcgtctacg
    12721 accggcgggt caccgaactc ccgttcgcgg cggcggtcgg ctcgcccgtg cagtgggtgt
    12781 tcgacaagac gcgggtcgcc ggggtgcgcg gcggccagta cctcgccgtc tcggtctcgg
    12841 ccgcgggcga ctggatcgac gtcccgacgg cgcgggccag ggagacgttc ctgcccgcgc
    12901 tcgaacggct cctccccggg gcgcgagacg cccgggtcgt ggacttcttc gtcaccaggg
    12961 agcggcgggc cacgttcctg caggggccgg gcagcggcgc gctcaggccg ctcgcggcga
    13021 cccgctggcc cggcctgttc ctcgccggct cgtggaccgc caccggctgg cccgacacga
    13081 tggagggcgc cgtgcgcagc gggctcaccg ccgccaggct ggtccgccgc cacctgagcg
    13141 gcggcagggg gcacaccagc ggggagccgg cgcgccgacc cctgcgggcg tacggcgcgg
    13201 gacgcgcctg ggcggccgag gaagcggtcc gatgagcggc aggccgggcg tgatcgtccc
    13261 gccccccgtg acggccgccc gcgagctggt ggagccggtg ctgcgcgccg ccgtgtccag
    13321 gctcgacccg gtcacggccc gcgtggccgc ctaccacctc ggctgggccg acgccgacgg
    13381 caggcccgcc ccgtccggcg ggggcaaggc gctgcgtccc gcgctcgccg tgctgtcggc
    13441 ccgcgccgcc gcggccgcgg actgcctgca cgccgccgcc gcgactgaac tcgtccacgc
    13501 cttctccctg ctgcacgacg acatcatgga cggcgacgcc acccgcaggc accgccgcgc
    13561 cgcctgggcc gtcttcggcg agcccgccgc catcctcgcg ggcgacgcgc tgctcgccct
    13621 cgccggggag ctgctgctgg aggacgactg ccccggtcac gcccgcgccg cccgcctgct
    13681 ggccgtcacc gtccgcgacc tgatcgccgg gcaggcgctc gacctggagt tcgagcggcg
    13741 cgacgacgtg acgctcgacg aatgcctgcg catggcggcc ggcaagaccg gctcgctcat
    13801 cgcgtgcgcc tgctcgatcg gggccgtcgc cgtggacggg cccgtcccgc tcgccggcgc
    13861 gctctcggcg ttcggcgccg aggtggggct cgccttccag ctcgccgacg acctcctcgg
    13921 catctggggc gcgcccgccg ccaccggcaa gcccgtgctg tcggacctgc gctcccgcaa
    13981 gaagtcgctg cccatcgtcg ccgccctcac cagcggcacc cgggcgggcg accggctcgc
    14041 cgccctgctg gcggcccccg ggccgctgcc ggaggccacc ctgcgccagg ccgccgcgct
    14101 cgtcgaggag gcgggcgggc gggcctgggc cgaggcggag gccaagcacc ggctcgacgc
    14161 cgcgggacgc cacctcgccg ccgccgggct gccgcccgcc gtgcacgccg acctcctcga
    14221 catcgcccgc ttcctcacct cgcgaggtca ctgacatgac gacagccgcc gcaccgtcct
    14281 cggccgcgct cgccctcgac gccgcctgcg accacctgct ggccctccag gagcccgccg
    14341 ggtggtggaa gggcgagctc cagacgaacg tcaccatgga tgccgaggac ctcctcctgc
    14401 gcgagttcct cggcgtgcgc aggccgcgcg acaccgagga ggccgcccgc tggatccgct
    14461 cccagcagcg cgacgacggc acctgggcca ccttccacgg cggtcccggc gacgtgtcca
    14521 ccacggtgga ggcgtacgcg gcgctgcggc tggccggcga cccggccgac gccgcccaca
    14581 tgcgggccgc cgcccggttc gtcctggacg cgggcggcat cgaggcgagc agggtgttca
    14641 cccgcatctg gctggccctg ttcggccagt ggagctggcg cgacctgccc gtcctgccgc
    14701 ccgagatgat gttcctgccg ccgtggttcc cgctcaacgt ctacgactgg gcgtgctggg
    14761 ccaggcagac catcgtcccg ctgacgatcg tcagcgccgc gcgcccggtg cgcccgctgc
    14821 cgttcacgct ggacgagctg cgcacgggac ggcgcgtgcg gcgggcgccg cgcggcggct
    14881 gggaggccgc gttcgccgcg ctcgaccggg cgctgcaccg ctacgagcgc cgcccggtgc
    14941 ccggactgcg ccgcgccgcg gtgcggcgcg ccgccgagtg gatcgtcgcg cggcaggagc
    15001 gcgacgggtc ctggggcggc atccagccgc cgtgggtgta ctccctcatc gcgctgcggc
    15061 tgtgcggcta cggcctcgac cacccggtga tgcgcaaggg cctcgacggt ctggagcgct
    15121 tcatcatcag ggacgagcag ggacgcaggc tggaggcgtg ccagtcgccc gtctgggaca
    15181 ccgttctcgc gatcaacgcg ctgcgcgacg ccgggctccc gcccgaccac gcggcgctgg
    15241 tcaaggcggc cggctgggtg ctgggcgagg agatcagggg gcccggcgac tggagcgtgc
    15301 ggcggccggg gctgcggccc ggcgggtggg cgttcgagtt cgacaacgac gtctaccccg
    15361 acgtggacga caccgccgag gccgtgctcg cgctgcggcg cgtggaccac cccgacgtcc
    15421 gcccggccgt cgagcgggcc gtgacctgga tggcgggcat ggtctcgcgc gacggcggct
    15481 tcgccgcctt cgacgccgac aacacccgca ccctgtgcac gcggctgccg ttctgcgact
    15541 tcggggccgt catcgacccg ccgtcggccg acgtcaccgc gcacaccgtc gaggcgctcg
    15601 tcgcggagcc gcccgcgccg cccgcccggc ccgacctcgt gcggcgcgcc gtcgtctggc
    15661 tgctgaaggc gcaggaggag gacggctcgt ggttcggccg ctggggcgcc aaccacgtgt
    15721 acggcacggg cgccgtggtg cccgcgctcg tcgccgccgg ggtgcgcacg gacgcccggt
    15781 gcgtgcgccg cgccgtggcc tggctggagt cgcaccagaa cgacgacggc ggctggggcg
    15841 aggacatgcg ctcctacacc gacccctcct ggatcgggcg gggcgcgtcc acgccgtcgc
    15901 agaccgcctg ggcgctgctg gccctgctgg ccgcgggaga gcggtcggag gcggtggagc
    15961 gcggcgtcgc ctggctcgtc tcccaccagc gtcccgacgg cacctgggat gagccgttct
    16021 tcaccggcac cggcttcccc ggcgacttct cgatcaacta ccacctgtac cgcctcgtct
    16081 tcccgatcag cgcactcggc cggtacgtcg ccgcggtggg cgccacggcg cagcctcacg
    16141 agacggccgt ggcggagcag gccgggcacc gcgaggccgg cgggacgcgg acggtcgccc
    16201 cgtgagcggg ctgctggtct tcaccgccct gggcctggag gcgcgggccc ttcgggaggg
    16261 cctgccgtcc atgccgggcg gggcgaaggt cgtccgcacc gggatgggcc cgcgcaacgc
    16321 cgcggcttac gcggcgcggg ccctgacggc ctcccgcgag ccggtggccg ggcggccggg
    16381 cgccgtggcg gtggcggggg tcggcggggc gctcgaccgg cggctgcggc ccggcgacgt
    16441 ggtggtggcg agcgaggtct ggtgggacgg gcagacgctg ccctgtccgt cggcccgcct
    16501 gctgcaggcc gagctggccc gcgcgggcgt gccggtcgtc accgggccgc tggtcacgtc
    16561 cggccacctc gtctcggggg cggaacgcgg cggcctggcg gcgcgcgggg cgctcgtcgt
    16621 ggacatggag tcgggccccg tcgcggccgc ctgcgccgag gcggcgcccg gcggcggcct
    16681 gccgttcgcg gcggtacgga tcgtcgtcga caccccggac gtcccgctgc tgcgtcccgc
    16741 gacgctgcgc ggcggcgcgc gggccctgcg gacgctgcgt cgcgccggca ggccgctcgc
    16801 ccgctgggcg ctcgcccagc tcatcacccc ggcaggcgcg gacggcgcgg ccggggccca
    16861 ccaggaggag gtgcggagca tatgagcatg cccgtccgcc aggcgctgcg catcggcggc
    16921 tacatcctcg gccagcgggt gcgcgggcgc gcgaagttcc cgctgctgct ggagctggag
    16981 ccgctgttcg cgtgcaacct gaagtgcgcc ggctgcggca agatccagca cccggccgac
    17041 gtgctgaagc gccgcatgcc ggtggagcag gccgtggccg cggtcgagga gtgcggcgcg
    17101 ccgatggtgt cgatcgccgg gggcgaaccg ctcatgcacc cggagatcgg cgagatggta
    17161 cgccgcctcg tcgccatgaa gaggtacgtg ttcctctgca cgaacgccct gctcatcccg
    17221 aagaagatcg accagttcga gccgtcgccg tacttcgcct ggaccgtcca catcgacggc
    17281 ctgcgggagc ggcacgacgc gtcggtctgc aaggagggcg tgttcgacca ggcggtggag
    17341 gccgtcaggg agtgcaggag gcgcggcttc cgcgtcacca cgaacaccac gttcttcaac
    17401 accgacagcc cgcagaccgt catcgacgtg ctcgactacc tcaacgacga cctgcgcgtg
    17461 gacgagatga tgatctcccc cgggtacgcc tacgagaagg cgcccgacca ggagcacttc
    17521 ctgggcgtgc aggagaccag ggcgctgttc cgcaaggcgt tctcgggcgg gaaccggcgc
    17581 aggtggaggt tcaaccacac gccgctgttc ctcgacttcc tggagggcag ggccgacttc
    17641 gcctgcacgg cgtgggcgat cccgtcgtac tcgctgttcg gctggcagcg gccctgctac
    17701 ctcatggcgg acggctacgc ggcgagctac cgcgagctgg tcgaggacac cgactgggac
    17761 tcctacgggc gggggcgcga cccgcgctgc gccaactgca tggcccactg cggctacgag
    17821 ccgacggccg tgttcgcgac gctgtcgtcg ctgaaggagt cgctgcgggc gatcagaggc
    17881 ggctgaaccc ctcccgctcg ggggcaggcg cgggagagcc ggtcgcatcc tgcgccatta
    17941 cttccgggat tcgtttcgtt gcgggaaccg gcacccccgc cgctaccgtc tgcgtagcgg
    18001 ccggtgacgt catcgccggc cccgtcgaac ggagcatccg tgatgaacgc cgatgtgatc
    18061 gtcgtcggag ccgggccgac cgggctcctg ctcgccgcgg aactgggcct cgccggcgtg
    18121 cgcgccgtgg tcgtcgaacg gctggcgcgg cgcagcgggc agtccaaggc gctcggcatc
    18181 cagccccgct ccgcggaggc gctcgacctg cgaggcctcc tggagcccct catggaccgg
    18241 gcgatccagc gggtggacgg cgggcatttc gccgggcttc ggctggacta caccgcctgg
    18301 aacacccggc acccgtactc gatcggcatc ccccaggggc gcgtcgaggc gctgctcgag
    18361 gaacggctcg gcgagctgga cgttcaggtc ctgcgcggac acgaggtgac cgcgctgtcg
    18421 caggacgccg acggggtcga ggcgactctg ctcgggcccg ggggcgagtc acggctcacg
    18481 gcccgtttcc tggtgggctg cgacggcggg cgcagcaccg tccgacggct gctgggcatc
    18541 ggctttcccg gcctggacgg gaagctgctc tcggtggtcg ccgacatcac gatctccgac
    18601 ccggacggcg ccgtgccgga gacctggacc ctgcccgtca tgacgcccga caagaccggc
    18661 aaggggtaca tcgcccccat cggcgacggc gtccaccggt tcctgttcta cggggccgag
    18721 cagcagcgac tctcccgcga cgcccccatc accgaggagg aggtgcggcg ggccctgcag
    18781 cacgagttcg gcccgggggt caggctcacg ggcgtgcgat gggcctcccg gttcaccgac
    18841 gcctcgcgcc aggtcgagcg gtaccgtcac gggcgcatcc tgctcgccgg agacgccgcg
    18901 cacatccact cgccctccgg cgggcaggga ctcaacctcg gcctgcagga cgcgttcaac
    18961 ctcgggtgga agctcgcggc ggagatcgcc gggtgggcgc acgacggact gctcgacacc
    19021 taccactccg aacggcatcc ggtcgccgca cgcgtcctcg ccaacacccg cgcccaagcc
    19081 gtcctgctcg tccacgacga ggagaacctg gccctgcgcg gcatcatgga ggagctcctc
    19141 cgggtgccgg aggccaaccg gatcgtcgcc ggcatgatct cggggctgga catccgccac
    19201 gacctgcccg gtcgccccca ccacctgctg gggcgccacg tccccaacct cgacctggtg
    19261 acggcgtccg gccccgagcg cgtggcgcgg ctgctgcgcg acggccgcgg cctgctgctg
    19321 acgaccgccg acgaggccac gttcgcgaag gccgccgagc cgtggtcggc caggatcggc
    19381 cgggcgcacg cgcaggccga gctcggtgcg gacgccgtgc tggtacggcc cgacggctac
    19441 gtctgctggg ccggttcggt cgccgacgtc tccggcctcg ccgacgccct ggcgcggtgg
    19501 gcgggcgcac ccgcgcggcc gtcctcgccg gtgaccaccc ctgaatgacg caccgggcga
    19561 gcggggcgac ggccgggttc acagcggctc tccgaggaag tggcgcaggt cgcgggtgcc
    19621 ggcctggtcc atggacagca ggacgaagaa gtcggccgtg ccgaagtcgc ggtcgtgggc
    19681 gggcgccccg cacacccacg cccccagccg caggtagccg cgcagcagcg gcggcagcac
    19741 gaaccggtcg ggacgcggcg cggcgccgcc ccgccacggc tcgtacgggc gcacccggtg
    19801 ctcctcgggg ccctgcggca ccatctcgac cacgcccgcc gcgacggcgc cgccgtcgtc
    19861 cagcggcacc gagcagcaac cggccagcca ccggtgaccg ccgtccacca tgtagcgggc
    19921 gatgcccgcc cacatcaggg cgaccaccgc gccgctccgg tggccggggt ggacgcaggc
    19981 gcgtcccacc tccaccaggt ccttcctgat ggcggtgagg ttgccgaggt cgaacctgcc
    20041 gtcggagcac agccggtccg cacgccccgg cgggagcagc cggtacgtgc cgaccacctc
    20101 gtcgccgcag cggacgagga ggtggtcgca gtaggcgtcg aaccggtcca cgtcgagccc
    20161 ggagacgggg ctgtcgagcc gcgcccccat ctcctcggcg aagacccggt acctgagccg
    20221 ctgggcggcc cgcacgtcgg cggggctcac cgcgaggccc acgctgtagg ggccgggagt
    20281 gccggtggcg ggggtgccgg tggtgagagg aatcgtcatg ggggggcgcg tccttccctg
    20341 gagaggtccc gcgcctatgg ggacacgccg acatgacggc cgactctccc gtcgtgggca
    20401 gcgaggcgtc cgcggggtga acctcgtgcc accgcgccgc tagcggcggc cggagccgcc
    20461 gaagacacag gccagggcgc ggaacggccc cggcgcggcc cctctcagcc gggccgggaa
    20521 gcgcagccag cccggcgtgt acgtctcggc gcgcccccgc tccacggcgg ccacgacggc
    20581 gcgggccacc cgctcagccg ggatgggcgc gggccggcgc ctggcgtacg ggacgccgcg
    20641 ccgcgcgaag aacggcgtgt ccacgacgcc gggcagcacg acggacaccc cgatgccgtc
    20701 gagctcgtag cgcaggctct cggcgaacgc gatcagcccg gccttggccg aggagtacac
    20761 ggcctcgtcg cgcacgccga cggccccggc gatggaggag acgtacacga ggtggccccg
    20821 gccgcgttcg atcatggcgg ggagcaggag cctggtcagc tcgacggggg cggtcaggtt
    20881 cgcggcgatc aggtgggcgg cggccccgtc gggcatcgcg gcgaccgggc cggcccagcc
    20941 cgcccccgcg ccgctcacca ggacgtccac cggtcccgcc cagcgggcga gcgcggcggc
    21001 ctcggtgacg aggtcggcgg tcagcgcctc gccgccgacc tcggccgcga cggcggccag
    21061 cctgccgggg tcgcgtccgg tcagcagcag ccgcgcgccg gacgccgcca tcgccctggc
    21121 cgtggccgcc ccgatgccgg acgacgcccc tgtgacgagc acgcgtgcac ctgccagcct
    21181 caacggttcc ctccccctgc cgctcctcgg ggtcgttccc gcaggcgggg ccgggtaagc
    21241 agcctgggct cggcgttccc ccaggtgagc ccgggtaagc gtcatgggct cgtcaggggc
    21301 gcaggcgcca gagggcggcg cgggagtcct ccccgtacgg ctgggtgccg atcgagccga
    21361 gcgcgtagag ctcgccggtt ccgggccggg ccacgaggtc ctcgacgctc gcccgcccgc
    21421 ctctccgcac cggcggccgc tcgcgcgtcc agcggccctc cgacaggtgc cacagctcgt
    21481 ccgggacgct caccgcccac agcccgcccc tgccgtcgga ggcggcggcg gtgaagccct
    21541 tccagccgtc gggccaggag gcgcccacca cgcacgtcca cgtcccgccg gcgagccgca
    21601 gcgcgacgga ccgtccgggg aagatgtcct ccccgtccat gtgctcgtgc tccatccact
    21661 ggaacgagcc gagcgcccac cactcctgcg gcccggtgcg cacgacggac ttcaccacgg
    21721 tccggccctg gtcggcgtgc acaggttcgg cgtcgggcgg caggccgagc gcgggcaccg
    21781 gcacggactg ccaggcggcg ccggtccagc gggcgagcgc ggacgacgcg tcggggtcca
    21841 tcgggtcggc gaagccgatc gcccacggct cgtcgccggg gccggtcagg gcgttgacgt
    21901 gcaggggcag cggcgcggag cgccaggcgg cgccgtccca gcgcgtcgag cctgtgctca
    21961 gcgcgagcca ggggccggcg gcgacggggc cggcccccgt gtaggcgccg aggccgagcg
    22021 gggtggcgcg ccaggcggtg ccgtcccaga cggtgagggc gggggcgccg tcggcggtga
    22081 ccaccaccca ggcgcggtcg gcggacgcgg cgccgagcgc tctgacctcc tgggaggagg
    22141 gagccgaggg cggcgcccgc catgccccgc cgtgccaacg gcgcggctcg atcgcgccac
    22201 tcgcccggac gaacagcgcc cagagggcgc cgtcggcggt ggcggcgccc gcgcgcagcg
    22261 acgtctcctc gggggcgtcg tccagccacg cgagctccca ccctgacgag gcggtggcgg
    22321 cccggaaccc gtcgtcgtgc cgggacgtca cggggcagtt cgcgggagtg gtgacgagcg
    22381 cgggggcggt cgtggtggcc agcggccctg gggtggacgc ggccgtggac accgacgggg
    22441 acgccgctgg ggacgcgccg ccccggcgcg gtgagcccgc gccgcaggcg gacacggcga
    22501 cgcaggcggc gatcaggacg gcgaccgccg ccctgacctt gcctggcgcc gctgctcccg
    22561 gcctggggag cggccgggcc gccggggtgc ccgcgctgcg ccgcctcatc tccgaccggc
    22621 ccggtcagcg caggtcggag acggtgccgc tgatcgtggt gccttcgcgg gggacgctgt
    22681 ggatggacag gttcccgccg atcgccgcga acgcgtcgcg catcgccgtg aagccgctgc
    22741 cggagtcggc gctggtgtag cccgcgccgt tgtcgctgat ggtcatgcgc agcccgctct
    22801 tgccgacggt cacggcgagc gagacgctgc tcgcgccgct gtgccgctcg acgttggcga
    22861 gggcctcgtg cagcacggcc aggacgcccc gcgtgacccg ctcgggcacg tcggcggcgg
    22921 gcagcgccca ggtctccagc gcgatgccgg tgcgctcgga ccactggccg gcgtacgtct
    22981 cgagctcctg ggccagcgcg cacgccggcg gggtgatctt cttggtgccc gtcatggctg
    23041 acacctcttc ctctcgggcc ggactgggag aagtgtgcgc agggcgacgt tgagttggcg
    23101 tttgttccat gttgatccgg ccccgaagtc ttccccgtcg cctacttcga aggcaagagg
    23161 atatcgacaa ttcctgggag cgatgatcac gcgaggggtc cggtgtgacg gaggaccgga
    23221 cgggcccggt gcgggccggg gtcaccgtgg tggccgcggg aaccgcctgg cgaggggaaa
    23281 ggggatgtcc gctcctttcc actctcaagc tatagcgcac cggggggctt gcggcaagac
    23341 ccgggtcgtg ccgcacaatc gtcggccgag cccaccacct gcggaaaccg acgccttcgc
    23401 gcgcgtgacg ggtcgcgagc gaccccatat cggagctgat cacatgaacc ccctgaccac
    23461 cagcgcgttc gaccttcccg aacgtctttc ccccaaggcc gacccggcgc tgatcgccgg
    23521 tgacgagggc cacttcacgg ccgtcgcgga gagcctcgaa cagacgatca ccgagctgtc
    23581 cgcccgcctc gacgccgaac gcagggcgcc cggcggcgcg ggccggcagg cgctggagcg
    23641 ggacctggag atccaccggc tgtccggccg gctgcgcgcg ctgcgccgct tcggcctgga
    23701 cctgtgtctc ggacggatgg tcctcgcgga cgaccccgaa cccgtgtacg tcggacggct
    23761 cggcctcacg gacggcgcgg gccgccggct gctgctcgac tggcgctccc ccgcggccga
    23821 gccgttcttc ggcgcgaccc acgccaaccc gatgggcctg gcgagccgcc gcaggtaccg
    23881 ctggacccgc ggccggatca gcgactactg ggacgaggtg ttcaccccgg acgggttcga
    23941 ggggcacgcg gcgctcgacg accagtccgc cttcatcgcc accctgggcg gcagccgctc
    24001 gccccggatg cgggacgtgc tcgccaccat ccaggccgac caggacgccg tcatccgcgc
    24061 ggggtcgcgc ggcgccctcg tcgtcgacgg cggccccggc acggggaaga ccgtcgtcgc
    24121 cctgcaccgc tccgcctacc tcctctactc cgacccccgc gtcggccggg gccggggcgg
    24181 cgtgctgttc gtgggccccc accagcccta cctggcctac gtcgccgacg tcctgcccag
    24241 cctcggtgag gagggcgtgc gcacctgcac cctgcgcgac ctcgtccagg aaggagccac
    24301 ggcggcgacg gagaccgacc cggacgtggc ccgcctgaag gggtccgccg acctggtgaa
    24361 ggcgatcgag ccggccgtca ggttctacga gaacccgccc gccgagggca tgacggtcac
    24421 gaccccctgg tccgacgtct ggctgagcgc cgacgactgg gccgaggcgt tcgaggcgcc
    24481 ggagcccggc accccgcaca acgaggcacg cgaccggatc ctggacgaac tggtcgcgat
    24541 cctgcgggac aagcacgacg aggacgtccc ggccgacctg ctccgcacgt cgctgctgcg
    24601 cgacagggaa ctgctcacgg ccctgaaccg cgcgtggccg ctgatcgagg cggcggacct
    24661 cgtcggagac ctgtggtcgg tgcccgcgta cctgcggatg tgcgcgccct ggctcggccc
    24721 cgacgacgtc aggaagctgc agcgcgcgga cgcccaggcc tggacggtgt ccgacctgcc
    24781 gctcctggac gcggcccgcc ggcggctcgg cgacccggag gcgtcgcggg cccgccgccg
    24841 gcgcgaggcc tccctcgccg cgcagcgcga ggacatgacg cgggtcgtcg acaacctgct
    24901 ccaagccgac gacgacggcg agggcctggt gacgatgctg cgcgggcagg acctgcgcga
    24961 ctccctcgtg gacgagaccg cgctgcccgc cgccgacccg gacctgctcg ccggcccgtt
    25021 cgcgcacctc gtcgtggacg aggcccagga gctcaccgac gcggagtggc agatgctgct
    25081 gcaccgctgc ccgtcacgga gcttcaccat cgtcggggac cgcgcccagg ccaggcacgg
    25141 gttcaccgag tcgtggcagg aacggctcga acgcatcggg ctcgaccgga tcaccctcgc
    25201 gtccctgacc atcaactacc ggacacccga agagatcatg gcggaggccg agccggtcat
    25261 ccgggccgtg ctcccggacg ccaacgtgcc gacctccatc cgccgcggcg gcgtacccgt
    25321 cgcgcaccgg cccgcctccg acctggacgc cgtcctcgac gcctggctct ccgagcacgc
    25381 cgacggcgtg gcctgcgtca tcggcgatcc gacgttccgg ccgacgtccc gcgtgcggtc
    25441 actcactcct gagctgtcga aggggctcga gttcgacctg gtcgtcctcg tcgacccgga
    25501 ggcgttcggc gacggcgtcg aaggagcggt ggaccgctac gtcgcgatga cccgcgcgac
    25561 ccagcgactc gtcatcctca cgagctcctg acgccgctga gggcgagcgc ggcggcgacg
    25621 gtgacggcca tcgccgccgc acccagccag gaggccgccg tgtatccggc gtcggtgggg
    25681 aacaccgagc cggccggggt gttcgcggcc agggtcaggc cgcccagagc gctgccgatc
    25741 gagaatccga cgctgcggac cacctggttg aagctcatca cgctggaggt ctcctccgcc
    25801 ggggtggcgg cgaggatcac ggcgggcatg gccgcagaga agacgccgac gcccagcccg
    25861 agcatgccca tcaccgcgaa cgacagccac agctggccgc gggccagcgc gaacagcgcc
    25921 agcgccgcca gcaccgccgt gccgccgcac gccagcaccg ccgccgccgt cagccgacgg
    25981 cgcagcggac gcaccagctt gccgccgacg aagcccagcg ccgagaacgg caccagcacc
    26041 aggcccgcga cgaacacgtc gacgccgaac ccgtgacccg ccgacccggg cgtctgcacg
    26101 taccgggtga ccagggtgag cagcaggtac atgccgacgc cgccgagcag catgacggcg
    26161 ttcgcgcccg ccacggcggg atcccgcagc agagccagat ccacc
//
