LOCUS       NZ_BBOK01000016        24049 bp    DNA     linear   CON 17-AUG-2024
DEFINITION  Streptomyces sp. NBRC 110030, whole genome shotgun sequence.
ACCESSION   NZ_BBOK01000016
VERSION     NZ_BBOK01000016.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. NBRC 110030
  ORGANISM  Streptomyces sp. NBRC 110030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Katano-Makiyama,Y., Hosoyama,A., Hashimoto,M., Tsuchikane,K.,
            Uohara,A., Kitahashi,Y., Ohji,S., Ichikawa,N., Kimura,A.,
            Yamazoe,A., Komaki,H., Igarashi,Y. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Streptomyces sp. NBRC 110030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 186614)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 97x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417675.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,152
            Genes (coding)                    :: 7,019
            CDSs (with protein)               :: 7,019
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 45 of 133
            Pseudo Genes (incomplete)         :: 107 of 133
            Pseudo Genes (internal stop)      :: 8 of 133
            Pseudo Genes (multiple problems)  :: 23 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:33:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 119565
            Orig. end                         :: 143614
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBOK01000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24049
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24049
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24049
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14049]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14049
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            507..1490
                     /locus_tag="APK71_RS32710"
     CDS             507..1490
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971744.1"
                     /locus_tag="APK71_RS32710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_030403306.1"
                     /transl_table=11
                     /translation="MRRLLLTAAATTAAALTLAACGTTEPAADKTEKKASGAITLKDGK
                     GTEVKLDGPATKVVATEWNVVESLVSLGVDPVGVADVKGYRTWDSAVPLKNEPKDIGTR
                     GEPSMDTVASLAPDLIVATTDLAPAAVKQLREVAPVIEVTSADGAGQIDRMLDNVDLIA
                     RATGTTDRAASLREDFEAKVAEGKKSLADAGMGGKNIAFADGYVASNQVSIRPYTATSL
                     IGEVNEAIGLKNAWAVKGDAAYGLGSTDVEGLTKLPKDTRFAYIGNDEDPSATPFTGEL
                     AKNSVWKSLPFVKAGDVHRLDDGIWMFGGPGSMEAYIDSVVGALTK"
     gene            1498..3582
                     /gene="cdtC"
                     /locus_tag="APK71_RS32715"
     CDS             1498..3582
                     /codon_start=1
                     /gene="cdtC"
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031636.1"
                     /locus_tag="APK71_RS32715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="siderophore ABC transporter permease CdtC"
                     /protein_id="WP_055469814.1"
                     /transl_table=11
                     /translation="MAVTATEAATEPAGARPPAVPPSRSGAAAVTAGIVLLVAVLAVVD
                     ITQGTAAVGPSEVFRALTGRASADDASVVVASRLPRMTAGLLVGAVLGMAGAVLQAVSR
                     NVLASPDTLAVNAGSYLALGLAAATGVSLPMLASSGVAFVGGLAAAAVVLGLSGLGTGT
                     VRLVLAGTALMLGLNSMTEGLLLLFPEQTEGLYQWNQGSISQNGFDGVLQMLPIALAGL
                     AGLLLTARRVDALALGDDAARGLGVPVRATRVTVVVLAALLSATAVTLAGPIGFVGLCA
                     PALVRPLARRFHGFSRSRTAMPAAALTGAALVLGSDVLLRALVAGDRSVSVPTGVVTSL
                     VGAVFLVTMALRVRDTAGAGAPDRLRTPGRGVFLATVAVLVVVLVGLVIAAVLVGDTKL
                     LLGDVVNWAQGRAGRAVSFVLDTRVPRVLAALCAGAALALAGTLVQAVTRNPLAEPNVL
                     GVTGGGALGAVLLVTTVPAAGTWGVAGAAFAGSAVTAALVFGLAARGGFRQNRLVLVGI
                     GVASGTAALISLLIVLTDPFNATKALTWLSGSTYGRTMPDVVPVALALVVGIGVAVARR
                     TELDLVSLDEDTPRLLGLRLAPGRLGFLVLSVVLSSTAVACAGTIGFVGLVAPHAARAL
                     VGRRHVRVVPVAVLLGAVLVCAADLLGRTVIAPAQLGAGLMTAVIGTPYFLYLLVRSRR
                     "
     gene            3641..4234
                     /locus_tag="APK71_RS32720"
     CDS             3641..4234
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031635.1"
                     /locus_tag="APK71_RS32720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3'-5' exonuclease"
                     /protein_id="WP_055469837.1"
                     /transl_table=11
                     /translation="MDLRDADGGHAGLLNVIDLEATCWDGQPPPGAVSEIIEIGLAVVD
                     LDARERVARHRILVRPARSRVSAFCTGLTGITPAEADRGVSLARACDTLVRDHGAGVRP
                     WASWGDHDRRQFVRQCAADGVAHPFGRPAERVHTNAKAVFTEAHGLRRRPGTARALEIA
                     GLPREGRHHRGVDDAWNIAALVLWLADRGAWPRS"
     misc_feature    complement(4339..4353)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.52"
                     /tool="antismash"
     misc_feature    4339..4356
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.07"
                     /tool="antismash"
     gene            4485..5819
                     /locus_tag="APK71_RS32725"
     CDS             4485..5819
                     /GO_function="GO:0004806 - triglyceride lipase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016042 - lipid catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971746.1"
                     /locus_tag="APK71_RS32725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipase family protein"
                     /protein_id="WP_030403309.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-08, bitscore:
                     27.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPRPRMLAAAIAAALALGAQAVPAVAADGAAGGATTTSRGVEIP
                     AFYTPPSELPGADGTLIRSEPLPLALSLPGIDGPLPGRATRLMYKSTDANGEAVAVTGA
                     YIEPAAKWRGDGPRPLVAVAPGTMGQGDQCAASMALEHPLRLNGQTVSVGYEDLSVYRL
                     LLRGVAVVVTDYVGLGTTDRLHTYVNRVDGAHAVLDAVRAARSLDQASVTSASRVGLFG
                     YSQGGGATAAAAELQPSYAPDVELAGTYAGAPPADLTEVTKAIDGSDLAGALGWSLNGF
                     LQTEPALRPIAERYVNEAGEKALKDLSTMCVGDALFGYGGKSSKEWTRTGQSLSDIIRA
                     EPALQDFLAKQRIGALRPAGPVRVATGTGDDLVPHGQARRLAVDWCDKGGKVTYVPVVL
                     PGVGSGLLNHFAPLLADQGNAISWLTDRLSGKAAGSNCWSMPVQP"
     misc_feature    5903..5923
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            6001..7488
                     /locus_tag="APK71_RS32730"
     CDS             6001..7488
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971747.1"
                     /locus_tag="APK71_RS32730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_051783581.1"
                     /transl_table=11
                     /translation="MPSTVARLPRQVREELARRLRRTKRAFREEDVQVVEGPLLKRAVG
                     ASALGNCMEWFDFGVYSYLAATLGKVFFPGASPAAQVISSFATFAAAFVVRPLGGLFFG
                     PLGDRVGRQKVLATTMIMMALGTFAIGLIPSYATIGIAAPVLLLLARMVQGFSTGGEYG
                     GATTFVAEYSPDRRRGFLSSWLDFGTFVGYALGSALVTVLNLSLSDEQMLAWGWRLPFL
                     IAGPLGVIGLYMRLKLEESPAFQQQLDEHEKGLAQESAGSEFKTIVREHWRPLLICMGL
                     VLLYNVTNYMVTGYLPTYQTETLNRSSGFADVLVLMGMVWIVLLITFLGRLSDHVGRRP
                     LYAGGAAAMIVLAVPAFLLLKADGIWAPVLGVLLLSTLLACFAAPSAATLPALFPTAVR
                     YAAMAIGFNFAVAAFGGTTPLVTEALVSITGDDLMPAYYLMVAGAIGLVAVKFLPESAQ
                     VPLHGSQPMVGSPQEQRELITTSKDLYSFSKDRSKAP"
     gene            complement(7452..8390)
                     /locus_tag="APK71_RS32735"
     CDS             complement(7452..8390)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446513.1"
                     /locus_tag="APK71_RS32735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_031185536.1"
                     /transl_table=11
                     /translation="MNATTTRGALLAALACVLVGGSFTANSLLGDYPYAGGQFLRYGLA
                     FLLLLPLAGPGAGARLRALGAGRWVRLALLAAVGMVGFNLAVLAAERTAEPAVPGVLVG
                     CAPVVVAVVVPLLEGRRPQRVVLYGSLFVALGAFTVQGWGRTDGAGLAFSVCALAGEVG
                     FAVLAVPVLRPLGPRLLSTVVCGVAAAESALAGVLADGSGWLRRPDAVETGALLWQAVV
                     VTVVGFVCWYMGMQRIGAERATLFSGLIPVAAAGTAPLVGTGSYGLAQAVGSALVFAGV
                     AVGSGASPRFARGRRPAVVRQGAFERSLEKL"
     gene            complement(8474..8965)
                     /locus_tag="APK71_RS32740"
     CDS             complement(8474..8965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971750.1"
                     /locus_tag="APK71_RS32740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MSMEG_6728 family protein"
                     /protein_id="WP_031085552.1"
                     /transl_table=11
                     /translation="MQTFLPHPGFRDSALALDRRRLGKQRVEALQVLRGLTVPGYGWRR
                     HPAVRMWTGYEEALVRYGLDVCRVWRERGHQDSCAASLVAGLAERRPGEPVREQAELAA
                     AGELPPWLGDEAFHRSHRSALVRKEPEVYAEQFPGVPDDLPYVWPASDRERGEADDGAP
                     "
     gene            complement(8982..10004)
                     /locus_tag="APK71_RS37930"
     CDS             complement(8982..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982463.1"
                     /locus_tag="APK71_RS37930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_055469838.1"
                     /transl_table=11
                     /translation="MSTDDHPRRGRLPLRLRRRALPWERQRPTWREARPAVVAAALRRA
                     GARPSGNWYVLGASTGVRPTRPLSGTVAGVEVVVWRDAHGRLVGGPGACPHLGAPLADS
                     PVRCGTLVCHWHGLALDGAPFAGWEPLPVHDDGVLVWVRLDTVGEEPPTPAPLVPARPP
                     RETALTSVWRGVGTCEPEDVVANRLDPWHGAWFHPYSFVDLTVVGTPGQHLRPDGDGDR
                     FVVDVSFRLTGRLVVPVRAEFTAPGPRTVVMRIAEGEGTGSVVESHATPLGPGTDGLPR
                     TAVVEAVLATSDRPGFPLARRLAPALRPLMRAAAGRLWRDDLAYAERRAHLRARGLFPG
                     "
     gene            complement(10001..10996)
                     /locus_tag="APK71_RS32750"
     CDS             complement(10001..10996)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324140.1"
                     /locus_tag="APK71_RS32750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_063788341.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.9e-118,
                     bitscore: 386.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1e-66,
                     bitscore: 218.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGRELDAAGVTDPALRAAYTRCRLLNARHGRTYFLATRLLPADR
                     RPAVHALYGFARWADDIVDDTADATPAERAAALARLDRLLRHALAGGRPAAEPVVLALA
                     DTAARYAIEPAHFTDFMASMRADLTVTDYATYADLRAYMHGSAAVIGLQMLPVLGTVTS
                     RARAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVQRDLLLWSRRTGRD
                     DPRITAALRAAEDLTRGVYREAQPGLAMLDPVARPCIRTAFLLYRNILDTIAGSGYAVL
                     HRRAVVPRRRRAAVAADGLVRVLAARLGARRAPTPTTVPYGAALDAKESG"
     gene            complement(10993..12510)
                     /gene="crtI"
                     /locus_tag="APK71_RS32755"
     CDS             complement(10993..12510)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120222.1"
                     /locus_tag="APK71_RS32755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_055469815.1"
                     /sec_met_domain="DAO (E-value: 1.3e-19, bitscore: 64.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTVTGRTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDPLPG
                     GRAGRRELGGYRLDTGPTVLTMPDLADEAFAAVGERLRDRVELLPLHPAYRACFADGTA
                     LDVHTDADAMETEVERFAGAGEAAGYRRLRDWLGRLYAVQMRRFIDANFDSPLGLLTPD
                     LARLAALGGFGRLDTRIGRFLTDERLKRVFSFQALYAGVAPSRALAAYAVIAYMDTVAG
                     VYFPRGGVHALPRAMAAAAAGAGADLRLGRAVTRLERSGNRVTAVVTDHERIPCDAVVL
                     TPDLPVVHRLLGRRPRRPLALRHAPSAVVLHAGTTRTWPHLAHHTLSFGAAWRRTFDEL
                     TRTGTLMTDPSLLITRPTAHDPSLAPEGRHLHYVLAPCPNTDIGPGARAWSDLAPRYRD
                     RLLATLERRGLTGIAAAVEEECLVTPADWTAQGHAAGTPFSVAHTFAQTGPFRPRNLVR
                     GTDNAVLAGCGTTPGVGVPTVLVSGKLAAARITGTPLRLRAARGGRR"
     gene            12847..14049
                     /locus_tag="APK71_RS32760"
     CDS             12847..14049
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324138.1"
                     /locus_tag="APK71_RS32760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_055469816.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.6e-94, bitscore:
                     310.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDADIVVVGAGAAGLSLVHRLPAGARHGAAPSVVLVDPPPGPLR
                     PARRTWCFWEAGPGRFDRAATASWQWLRVHGRDGRAVRRNIAPARYKMVRSDDFEALVE
                     RDLKDRPGLRRVEATVGAVTGLPDATVRLAATDAAGAPVGLRARWVFDSRPPDRLPAAR
                     TRLLQHFRGWFVRTERPVFDPEVVDLMDFRTVQPRRGLSFGYVLPTGRHTALVEYTEFG
                     PAPLTTEAYDRVLEDYTRRVLRTGATEVLSTEQGVVPMTDAVFGRRAEGCDRVFRIGVA
                     GGATRASTGYTFAAVQRQSEAVARAVRAGRRPVPPAPHPARARWMDAVLLRALDTGRVD
                     GPDLFFRLFDRVPAGRLLRFLDGRSRLYEDLAVGVRVPVLPMLRTAAELPWLPRRHLPV
                     R"
     gene            14445..15947
                     /locus_tag="APK71_RS32765"
     CDS             14445..15947
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525638.1"
                     /locus_tag="APK71_RS32765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_051909005.1"
                     /sec_met_domain="DAO (E-value: 7.8e-11, bitscore: 35.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPAGPGRERVEGDAPSVAVVGGGIAGLAAATLLAERGVRVVLHE
                     REPVLGGRVAGRTVALPDGTPATMSRGFHAFFRQYYNLRSLLRRCDPGLAMLTGLPDYP
                     LRHSSGLHDGFRRIPRTPPFSALAFVALSPSFGLRDLTALRPSAALPLLDVRTRRVHER
                     LDTVSAADFLDALRFPAAARHLAFEVFSRSFFADPGELSAAEMALMFHIYFLGSSEGLL
                     FDVPREPFPQALWDPLAGHLVRHGVEIRTSTSVEAVRPGPSGGRLVVDAAGARPYDAVV
                     LAMDVGGLRGVVSRSPHLGDAGWRARVARLRNAPPFLVSRLWLDRPVAPGRPGFLGTSG
                     YGSLDNVSVLSHWEGEAARWAARTGGCVVELHAYAVPSQAVREVEEKRLVDQLHRVYPE
                     TLRARVLAARHEWRADCPLFAVGGYGDRPTVRTPDPAVVVAGDLVRTDLPVALMERAAT
                     SGFLAAGALLERWGVRGETLWTVPDRGRSAPLRALARRFGAY"
     gene            complement(16126..17004)
                     /locus_tag="APK71_RS32770"
     CDS             complement(16126..17004)
                     /NRPS_PKS="Domain: PKS_KR (9-177). E-value: 6.7e-17. Score:
                     53.9. Matches aSDomain:
                     nrpspksdomains_APK71_RS32770_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521778.1"
                     /locus_tag="APK71_RS32770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_030403318.1"
                     /sec_met_domain="adh_short (E-value: 6.3e-35, bitscore:
                     114.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDSPLDHRTVVVTGAARGLGAALARACARRGARLALLGLEKPLL
                     DALAADLPTPALAVETDVTDPAALADAAEETRRRLGRPSVVVANAGIAHGGPFATSDPA
                     EWRRVVDVNLTGSAHTARAFLPDLLDTAGYHLQIASLASLGAAPMMSAYCAAKAGVEAF
                     THSLRAEVAHRGVAVGTAYLNWMDTDMIRDADRYPVLRGLRAHMPPPARRTFPPEDVAA
                     RLVRAVERRRTAVYVPGWLRLVQWGRAALPPAVVRLSRHELPRMEAEEPLGHTGPLGAG
                     GLADRAADRGR"
     aSDomain        complement(16474..16977)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS32770_PKS_KR.1"
                     /evalue="6.70E-17"
                     /label="APK71_RS32770_PKS_KR.1"
                     /locus_tag="APK71_RS32770"
                     /protein_end="177"
                     /protein_start="9"
                     /score="53.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVVVTGAARGLGAALARACARRGARLALLGLEKPLLDALAADLPT
                     PALAVETDVTDPAALADAAEETRRRLGRPSVVVANAGIAHGGPFATSDPAEWRRVVDVN
                     LTGSAHTARAFLPDLLDTAGYHLQIASLASLGAAPMMSAYCAAKAGVEAFTHSLRAEVA
                     HRGVA"
     CDS_motif       complement(16888..16977)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS32770_0001"
                     /evalue="5.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="APK71_RS32770"
                     /protein_end="39"
                     /protein_start="9"
                     /score="19.1"
                     /tool="antismash"
                     /translation="TVVVTGAARGLGAALARACARRGARLALLG"
     gene            complement(17066..18694)
                     /locus_tag="APK71_RS32775"
     CDS             complement(17066..18694)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446458.1"
                     /locus_tag="APK71_RS32775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_030403319.1"
                     /sec_met_domain="DAO (E-value: 5.6e-10, bitscore: 32.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDAVDAVVVGAGPNGLVAANLLADAGWSVTVLEEQPEPGGAVRH
                     DDAVAPGFVNDLFSSFYPLAAASPVLGGLHLEEHGLRWAHAPHVLAHPLTDGTCAVLDR
                     DLATTAASLDAFAPGDGAAWERLHAVWDRYRADIVDALFTPFPPVRAGARLALRLRGAG
                     GLRLARTLVLPVRRMGEEEFRGEGGRLLLAGNALHADLAPEAAGSGGFGWLMSMLGQTY
                     GFPVPVGGSGALTEALVRRLRARGGTLHCGRRVDRVLVRDRRAAGVRTADGDAVTARRA
                     VLADVSVPALYGRLVAPADLPDQVRRDLRRFQWDFATFKVDWALDGPVPWRCEEAAGAG
                     TVHLSDGLDELTRFAAQIAMRQVPDRPFSLFGQMTTTDPTRSPAGTESAWAYTHVPHDI
                     RGDAGDEGVTGSWDRREQELMADRVERQVERFAPGFRALVRARRVLAPPTLQAMNANLE
                     GGAINGGTTAMHQQLVFRPVPGTGRPETPVTGLFLASAGAHPGGGVHGAPGANAARAAL
                     RQHRFAGLARLQRSLTRRDRTGDRC"
     gene            complement(18687..19193)
                     /locus_tag="APK71_RS32780"
     CDS             complement(18687..19193)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-141). E-value:
                     1.8e-09. Score: 30.1. Matches aSDomain:
                     nrpspksdomains_APK71_RS32780_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031629.1"
                     /locus_tag="APK71_RS32780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SRPBCC family protein"
                     /protein_id="WP_030403320.1"
                     /transl_table=11
                     /translation="MAIRHRLIQATPQAVWDVLADGDAYVQWVVGPSKVTPRDGRWPQV
                     GATIAYEVRLGPLLLDNESVVRRCVEGSVLELEAKAGRLGTARIAVELRPWGEQCLVIV
                     DEHPLRGPGGLLHNVGVEALIQVRHRAMLARLAKLCESRAGDRCRPDPPDTVGAVHHRR
                     GSGRA"
     aSDomain        complement(18771..19181)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS32780_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.80E-09"
                     /label="APK71_RS32780_Polyketide_cyc2.1"
                     /locus_tag="APK71_RS32780"
                     /protein_end="141"
                     /protein_start="4"
                     /score="30.1"
                     /tool="antismash"
                     /translation="HRLIQATPQAVWDVLADGDAYVQWVVGPSKVTPRDGRWPQVGATI
                     AYEVRLGPLLLDNESVVRRCVEGSVLELEAKAGRLGTARIAVELRPWGEQCLVIVDEHP
                     LRGPGGLLHNVGVEALIQVRHRAMLARLAKLCE"
     misc_feature    complement(19392..19406)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 27.13"
                     /tool="antismash"
     misc_feature    19393..19407
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.66"
                     /tool="antismash"
     misc_feature    complement(19393..19408)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            19472..20638
                     /locus_tag="APK71_RS32785"
     CDS             19472..20638
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031628.1"
                     /locus_tag="APK71_RS32785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S1 family peptidase"
                     /protein_id="WP_055469817.1"
                     /transl_table=11
                     /translation="MRRSRLRHLGLAGLLVLGSLTAVGTLPASAAGAPAASVDERPASA
                     GLLDAMQRDFGLTRDQAEDRLAAERDATEVEPVARRAAGAAYGGSWFDADTGRLTVAVT
                     SDAAPSTLSAVRATGAQVRTVEHSARQLDAAKARVDRLDAPAGVSGWHVDQRAGTVVVD
                     VVASEQADNDVQRFLKQARETGPVTVRAVPSAPGTFAAGTVGGDPYYTGNVRCSIGFSV
                     HGGFVTAGHCGRAGAGVSGWDGSYIGTFQGSSFPDNDYAWVSVGSGWWTVPVVLGWGTV
                     SDQLVRGSNVAPVGASICRSGSTTHWHCGTVLAHNETVNYSDGSVVHQLTKTSVCAEGG
                     DSGGSFISGDQAQGVTSGGWGNCSSGGETWFQPVNEILNRYGLTLHTA"
     gene            complement(20730..21173)
                     /locus_tag="APK71_RS32790"
     CDS             complement(20730..21173)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031627.1"
                     /locus_tag="APK71_RS32790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030403322.1"
                     /transl_table=11
                     /translation="MIEWVPLGSGARPVPRPVAAPLVWAGAFGGALLLVGLLNGTVGSG
                     RPGLALVALSLLAALLGLCAPFAAAPGTAVLCWLSLNGFAIPPAGTLTWAGRRDAFWLA
                     CLLGAALVGTALARLVHARAAYRRLTTATGPDAPEPGTGPGDV"
     gene            complement(21287..22612)
                     /locus_tag="APK71_RS32795"
     CDS             complement(21287..22612)
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446464.1"
                     /locus_tag="APK71_RS32795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation:proton antiporter"
                     /protein_id="WP_055469818.1"
                     /transl_table=11
                     /translation="MGHADTLLAMGGAFVAAAFLARLGGRIGLPTIPLFMLAGILLGPH
                     TPGFVLVEDAHDFEMLSALGLVLLLFYLGLEFHLDDLKSGGKRLLTAGGVYLLLNVGAG
                     LGFGFVLGWGVREALVLAGVLGISSSAIVTKILIDLGRIGRPETRLILGVIVVEDIFLA
                     LYLAALQPVISGAHGVADMALQAGKAFGFLLVLAAAARYGTRLVGRLIHTRDNELLVIS
                     FLGAAVLVAGVSELLGVADAIGAFMVGLILAGTPSGPRIRELVHPLRDAFAAIFFFAFG
                     LAIDPGDLASVAGPVAAAAALTVVMNVVAGLCVARVYRYGSEPAAEIATTLVARGEFAL
                     ILAAMAAGAGLDARLAPFIAGYVLVLAVLGPVVAGRAHVLAGALRAAGRLLPGAPAPAA
                     APGDGSGAGDEGTDADSRPVPAGASCSSGSGTSSPEHAKTER"
     misc_feature    22665..22680
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.02"
                     /tool="antismash"
     misc_feature    complement(22668..22683)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.32"
                     /tool="antismash"
ORIGIN
        1 ccgtaccggg gccgctgggg gcggcccgat ccggacggtc cggccgccgt ggaccgggcg
       61 ctcgcgctca ccggcgtcga cggcctcgcc gaccggggcg ccgaccacct ctccggcgga
      121 cagctgcagc gcgtgtggct cgcgagctgc ctcgcccagg agaccggcgt actgctcctg
      181 gacgaaccca cgacctacct cgacctgcgc taccaggtcg aactgctcga cctgatccgc
      241 gacctggcgg acgttcacgg catcgccgtc ggagtcgtcc tgcacgacct cgaccaggcg
      301 gcggccgtcg ccgaccggat cacgctgctc gaagccggcc ggatcgtcgc cgacggcacg
      361 cccgaggacg tactgacgcc cgaacgcctg accgccgtct acggcatccg catcgacgtc
      421 gacaccgacc ccctcaccgg ccggctgcgc acccgcccgg tcggccgcca ccacatacgc
      481 acccccgaaa ggctcggcac cacctcatga gacgcctcct gctcaccgcg gccgccacca
      541 ccgccgcggc gctcaccctg gccgcctgcg gcaccaccga acccgccgcc gacaagacgg
      601 agaagaaggc ctccggggcg atcacgctca aggacggcaa gggcaccgag gtgaagctcg
      661 acggaccggc caccaaggtc gtcgccaccg agtggaacgt cgtcgagagc ctcgtctcgc
      721 tcggcgtcga cccggtcggc gtggcggacg tcaagggcta ccggacctgg gacagcgccg
      781 ttccgctgaa gaacgaaccg aaggacatcg gcacccgcgg cgagccgagc atggacaccg
      841 tcgcctccct cgcccccgac ctcatcgtcg ccaccaccga cctcgccccc gccgccgtga
      901 agcagctccg cgaggtcgcg ccggtgatcg aggtgacctc cgccgacggc gcggggcaga
      961 tcgaccggat gctcgacaac gtcgacctca tcgcccgggc caccggtacc acggaccggg
     1021 cggcgtcgct gcgcgaggac ttcgaggcga aggtcgccga gggcaagaag tccctggcgg
     1081 acgccgggat gggcggcaag aacatcgcct tcgccgacgg ctacgtcgcc tccaaccagg
     1141 tctcgatccg tccctacacc gcgacctccc tcatcggcga ggtcaacgag gccatcggcc
     1201 tgaagaacgc ctgggcggtg aagggcgacg cggcctacgg tctcggcagc accgacgtcg
     1261 agggcctgac caagctgccc aaggacaccc ggttcgccta catcggcaac gacgaggacc
     1321 cgagcgccac cccgttcacc ggtgagctgg cgaagaactc ggtctggaag tcgctgccgt
     1381 tcgtgaaggc cggggacgtg caccggctcg acgacggcat ctggatgttc ggcggtcccg
     1441 ggtcgatgga ggcgtacatc gactccgtcg tcggcgccct gacgaagtag cggggccatg
     1501 gccgtcaccg caaccgaagc cgcgaccgag cccgccgggg cccgtccgcc ggcggttccc
     1561 ccctcccggt cgggcgcggc cgcggtgacg gccgggatcg tcctgctggt cgccgtcctc
     1621 gcggtcgtcg acatcaccca gggcaccgcc gccgtcggac cgtccgaggt gttcagggcc
     1681 ctgaccgggc gggcctccgc ggacgacgcg tccgtcgtgg tcgcctcccg gctgccgcgc
     1741 atgaccgcgg ggctgctggt cggcgccgtc ctgggcatgg ccggcgccgt gctccaggcg
     1801 gtcagccgca acgtgctcgc ctcccccgac accctcgcgg tgaacgcggg ttcctacctg
     1861 gcgctgggac tggccgccgc caccggcgtg tcgctgccga tgctcgcctc ctccggcgtc
     1921 gccttcgtgg gcggcctcgc ggcggcggcc gtcgtgctcg gcctgtccgg cctgggcacg
     1981 ggcaccgtcc gcctcgttct ggcgggcacc gcgctgatgc tgggcctgaa ctccatgacg
     2041 gaggggctgc tgctgctctt cccggagcag acggagggcc tctaccagtg gaaccagggc
     2101 agcatctccc agaacggctt cgacggcgtc ctgcagatgc tgccgatcgc cctggccggg
     2161 ctggccggcc tgctgctgac ggcccgccgg gtggacgcgc tggccctggg cgacgacgcg
     2221 gcccgcggtc tcggcgtccc ggtccgggcc acccgggtca cggtcgtcgt gctcgcggcc
     2281 ctgctgtccg cgacagcggt caccctcgcc ggcccgatcg gcttcgtcgg cctgtgcgcc
     2341 cccgccctgg tgcgcccgct cgcacgccgt ttccacggct tcagccgctc ccgtacggcc
     2401 atgccggcgg cggcactcac cggcgcggcc ctggtgctcg gctcggacgt gctgctgcgg
     2461 gccctggtcg ccggggaccg ctcggtgtcc gtgcccacgg gcgtggtgac cagcctggtc
     2521 ggcgccgtgt tcctggtcac catggccctg cgggtgcggg acaccgccgg ggccggggcg
     2581 ccggaccggc tgcgcacccc cggccggggg gtgttcctgg ccacggtcgc cgtcctggtc
     2641 gtggtcctgg tggggctcgt gatcgccgcc gtgctggtgg gcgacaccaa actgctgctc
     2701 ggtgacgtcg tcaactgggc ccagggccgg gccgggcgcg ccgtctcctt cgtgctggac
     2761 acgcgggtgc cgcgggtgct ggccgcgctg tgcgcgggtg cggcactggc ccttgcgggc
     2821 acgctggtgc aggcggtcac ccgcaacccg ctcgccgagc cgaacgtcct cggggtgacc
     2881 ggcggcggcg cgctgggcgc ggtgctcctg gtgaccaccg tgccggccgc cgggacctgg
     2941 ggcgtggcgg gggcagcctt cgcggggtcc gccgtcaccg ccgccctcgt cttcgggctc
     3001 gccgcccggg gcggtttccg gcagaaccgg ctggtcctgg tcggcatcgg cgtggcctcc
     3061 gggacggcgg cgctgatcag tctgctgatc gtgctcaccg acccgttcaa cgccaccaag
     3121 gcgctgacct ggctgtcggg ttcgacctac gggcggacca tgccggacgt cgtgcccgtc
     3181 gcgctggcgc tggtcgtcgg catcggtgtg gccgtcgccc ggcgcaccga gctggacctg
     3241 gtctcgctgg acgaggacac cccgcggctg ctcggtctgc ggctggctcc ggggcggctc
     3301 ggattcctgg tgctgagcgt ggtcctcagc tcgaccgcgg tggcctgcgc gggcacgatc
     3361 ggcttcgtcg gtctggtcgc cccgcacgcg gcacgcgccc tggtgggccg gcggcacgtg
     3421 cgcgtggtgc cggtggcggt cctgctcggc gccgtcctcg tctgcgccgc cgacctcctc
     3481 ggccgcacgg tgatcgcccc ggcccagctg ggcgcggggc tgatgacggc ggtgatcggc
     3541 acgccctact tcctgtacct gctggtccgt agccgtcgct agccgactcc gcgggggaaa
     3601 cccgggtgct cgcggatccg tggccccgta cggtgccgcc gtggacctgc gcgacgcgga
     3661 cgggggccac gcgggcctgc tgaacgtcat cgatctggag gccacctgct gggacggtca
     3721 gccgccgccc ggcgcggtga gcgagatcat cgagatcggg ctcgccgtgg tggacctcga
     3781 cgcccgggag cgggtggccc ggcaccggat cctggtgcgg cccgcccgct cccgggtcag
     3841 cgcgttctgc accgggctga ccggcatcac cccggccgag gccgaccggg gcgtgagcct
     3901 cgcccgggcc tgcgacacgc tggtgcgcga ccacggcgcg ggcgtgcggc cgtgggcgag
     3961 ctggggcgac cacgaccgca ggcagttcgt ccgccagtgc gcggcggacg gggtcgccca
     4021 tcccttcggc cggccggccg agcgcgtgca caccaacgcc aaggcggtct tcaccgaggc
     4081 ccacgggctg cgcaggcgtc ccggcacggc gcgggcgctg gagatcgccg gactgccccg
     4141 ggaggggcgg caccaccgag gggtggacga cgcctggaac atcgccgcgc tggtgctctg
     4201 gctggcggac cggggggcgt ggccgcgctc ctgaggggcc gtcgcccggc ggacggcgct
     4261 tgccgggcag cacatgccgg gcagcgcagc gtgtgccggg cagcgtggga tccgaccgcg
     4321 cttgttagac agcgcgtcaa gttactgaac cgtaatgagc gcgatgctac ccctggtaac
     4381 cccgggccgg ttacggtccg gtaaccccac aggagcagcg cgaccacggt cctggcccac
     4441 gggaccgcgg acgacggatc cggcccttcc ccaggaggtt cgccatgccc ccacgtcccc
     4501 gcatgctcgc cgcggcgatc gccgccgcgc tcgccctcgg tgcccaggcc gtcccggccg
     4561 tcgcggccga cggcgcggcc ggcggtgcga ccacgacgtc ccgcggcgtc gagataccgg
     4621 ccttctacac cccgccgtcc gaactcccgg gcgccgacgg cacgctgatc cgcagcgaac
     4681 cgctgcccct ggcgctgagc ctgcccggca tcgacggtcc gctccccggc cgggcgaccc
     4741 ggctgatgta caagtccacc gacgcgaacg gcgaggcggt ggcggtcacc ggcgcctaca
     4801 tcgaaccggc cgcgaagtgg cgcggcgacg gaccgcgccc cctggtcgcc gtggcgcccg
     4861 gcaccatggg acagggcgac cagtgcgccg cctccatggc cctggagcac ccgctgcggc
     4921 tcaacggcca gacggtctcc gtcggttacg aggacctgtc ggtctaccgg ctgctgctgc
     4981 gcggcgtggc cgtcgtggtc accgactacg tcggcctcgg caccaccgac cggctgcaca
     5041 cctatgtcaa ccgcgtcgac ggggcccacg ccgtgctgga cgccgtacgc gccgcgcgct
     5101 ccctcgacca ggcgtccgtc acctccgcct cccgcgtggg gctgttcggc tacagccagg
     5161 gcggcggcgc cacggcggcc gcggccgaac tgcagccctc ctacgccccc gacgtcgaac
     5221 tggccggcac ctacgcgggg gcaccgcccg ccgacctgac ggaggtgacg aaggcgatcg
     5281 acggcagcga cctggcgggc gcgctgggct ggtcgctcaa cggcttcctg cagaccgagc
     5341 ccgccctgcg gcccatcgcc gagcggtacg tcaacgaggc gggcgagaag gcgctgaagg
     5401 acctgtcgac catgtgcgtg ggcgacgcgc tcttcggtta cggcggcaag agcagcaagg
     5461 agtggacgag gacggggcag tcgctgagcg acatcatccg ggccgagccc gcgctccagg
     5521 acttcctggc caagcagcgc atcggcgcgc tcaggcccgc ggggccggtc cgcgtggcca
     5581 ccggcaccgg cgacgacctg gtcccccacg gccaggcccg ccggctggcg gtcgactggt
     5641 gcgacaaggg cgggaaggtc acctacgtcc ccgtggtcct gccgggcgtg ggcagcggcc
     5701 tgctcaacca cttcgccccg ttgctcgccg accagggcaa cgccatctcc tggctcaccg
     5761 accggctctc cggcaaagcg gccggctcta actgctggag catgccggtc cagccctgag
     5821 ccgtaccgtc gcgccgctgc ccgggccgtc cgcgccgccc cgggcagcgg ctccggcatg
     5881 cgccggtcgc gggttgcggc acagaattcg ctcaggcgaa ctgtgacgga gcgacaggaa
     5941 ggcagcggcg tggccgacgc gaagcccgac ggcgggtccg gtccccggag cggggcgaag
     6001 atgccgagta cggtcgcgcg cctgccgcgg caggtccgcg aggagctggc ccgccggctc
     6061 cgccgtacca agcgggcctt tcgcgaggag gacgtccagg tcgtcgaggg accgctgctc
     6121 aagcgcgcgg tcggggcctc cgcgctcggc aactgcatgg agtggttcga cttcggcgtt
     6181 tacagctatc tggcggccac cctcggcaag gtgttcttcc cgggcgcctc ccccgcggcc
     6241 caggtgatct cctccttcgc caccttcgcc gcggcgttcg tcgtacgccc gctcggcggc
     6301 ctgttcttcg gcccgctcgg ggaccgcgtc ggacggcaga aggtgctcgc cacgaccatg
     6361 atcatgatgg cgctgggcac cttcgccatc ggcctcatcc ccagctacgc gaccatcggc
     6421 atcgccgccc cggtcctgct gctgctcgcc cggatggtcc agggcttctc caccggcggc
     6481 gagtacgggg gcgcgaccac cttcgtcgcc gagtactcac ccgaccggcg gcgcggcttc
     6541 ctctccagtt ggctcgactt cggcaccttc gtcggctacg ccctgggctc ggcgctggtc
     6601 accgtgctga acctgtccct gtccgacgag cagatgctcg cctggggctg gcggctgccg
     6661 ttcctgatcg ccggtccgct cggcgtcatc ggcctgtaca tgcggctcaa gctggaggag
     6721 tcccccgcct tccagcagca gctcgacgag cacgagaagg gcctggccca ggagtcggcg
     6781 ggcagcgagt tcaagacgat cgtgcgcgag cactggcgcc cgctgctgat ctgcatgggc
     6841 ctggtgctgc tctacaacgt caccaactac atggtgacgg gctatctgcc gacgtaccag
     6901 acggagaccc tgaaccgttc cagcgggttc gcggacgtgc tggtgctgat ggggatggtg
     6961 tggatcgtgc tgctgatcac cttcctcggc cggctcagcg accacgtcgg ccgccgcccg
     7021 ctgtacgccg gcggcgcggc ggcgatgatc gtcctcgccg ttccggcgtt cctgctgctg
     7081 aaggcggacg gcatctgggc gccggtgctc ggggtactgc tgctgtccac cctgctggcc
     7141 tgcttcgccg cgcccagcgc cgccacactg ccggcgctgt tccccaccgc cgtgcgctac
     7201 gccgcgatgg ccatcggctt caacttcgcc gtcgccgcct tcgggggcac cacgccgctg
     7261 gtcaccgagg cgctggtgag catcaccggc gacgacctga tgccggcgta ctacctgatg
     7321 gtggccggcg ccatcgggct ggtggccgtg aagttcctgc cggagagcgc ccaggtgccg
     7381 ctgcacggct cgcagcccat ggtcggctcc ccgcaggagc agcgtgagct catcacgacc
     7441 tcgaaggacc tctacagctt ctccaaggac cgctcgaagg cgccctgacg caccaccgcc
     7501 ggccgtcgtc cgcgcgcgaa gcggggcgac gcgcccgacc ccacggccac tccggcgaag
     7561 accagggcgc tgcccaccgc ctgggcgagg ccgtaggagc ccgtgccgac cagcggtgcg
     7621 gtaccggcgg cggcgaccgg gatcagcccg gagaacaggg tggcgcgctc ggcgccgatc
     7681 cgctgcatgc ccatgtacca gcacacgaac ccgacgacgg tgaccaccac cgcctgccac
     7741 agcagcgcgc ccgtctccac cgcgtccgga cggcgcagcc acccgctccc gtcggccagg
     7801 acgcccgcca gggccgactc ggccgccgcg acgccgcaca ccacggtgga cagcagccgc
     7861 gggcccaggg gccgcagtac gggcacggcg agcacggcga agccgacctc cccggccagc
     7921 gcgcacaccg agaaggcgag gcccgcgccg tcggtgcgtc cccagccctg gacggtgaag
     7981 gctcccaggg ccacgaacag ggacccgtac aggacgaccc gctgcggccg gcgcccctcc
     8041 aggaggggca cgacgacggc gacgaccacg ggcgcgcagc cgacgaggac gccgggtacc
     8101 gcgggttccg ccgtgcgttc cgcggcgagg acggccaggt tgaagccgac catgcccacg
     8161 gccgcgagca gcgcgaggcg cacccagcgg ccggcgccga gcgcgcgcag ccgggctccc
     8221 gcgccggggc cggccagcgg gaggagcagc aggaaggcca ggccgtagcg caggaactgg
     8281 ccgcccgcgt acgggtagtc gccgagcagg ctgttggcgg tgaaggatcc tccgacgagg
     8341 acacaggcga gcgcggcgag cagggccccg cgcgtggtgg tggcgttcat gcgcacgacg
     8401 ctagggaggg cggcggcccg ccacggggtc cacttcgcgg gcgccgtcgg ggaccaatcg
     8461 cggcgcggag cccctagggg gcgccgtcgt ccgcttcccc gcgctcccgg tccgaggccg
     8521 gccagacgta cggcaggtcg tcggggaccc cggggaactg ttcggcgtac acctccggct
     8581 ccttgcgcac cagcgccgag cggtggctgc ggtggaaggc ctcgtcgccg agccagggcg
     8641 gcagttctcc cgcggcggcc agctccgcct gctcccgcac cggctcgccc gggcggcgct
     8701 cggcgagccc cgcgacgagt gaggccgcgc aactgtcctg gtggccccgc tcccgccaga
     8761 cccggcagac gtcgagaccg tagcggacga gcgcttcctc gtagccggtc cacatccgca
     8821 ccgccgggtg ccggcgccag ccgtagccgg ggaccgtgag gccgcgcagc acctggaggg
     8881 cctccacccg ctgtttgccg aggcgccgcc ggtccagggc cagtgccgag tcccggaaac
     8941 cggggtgcgg aaggaaggtc tgcatggcgg tgccgctccg ttcagccggg gaagaggccg
     9001 cgggcgcgca gatgtgcgcg gcgttcggcg taggcgaggt cgtcgcgcca caggcggccc
     9061 gcggcggcgc gcatcagcgg gcgcagggcc ggtgccagac ggcgggccag ggggaagccg
     9121 gggcggtccg aggtggcgag caccgcctcg acgacggcgg tgcgcggcag cccgtccgtg
     9181 cccgggccga gcggtgtggc gtggctctcc accacggacc cggtgccctc gccctcggcg
     9241 atgcgcatga cgacggtgcg gggtccgggc gcggtgaact cggcccggac ggggacgacc
     9301 aggcggccgg tcagccggaa cgacacgtcc acgacgaagc ggtcgccgtc cccgtccggg
     9361 cgcaggtgct gcccgggcgt cccgacgacg gtgaggtcca cgaaggagta cgggtggaac
     9421 caggctccgt gccacgggtc gagccggttg gcgaccacgt cctcgggttc gcaggtcccc
     9481 accccgcgcc acaccgacgt cagggccgtc tcccggggcg gccgggcggg cacgaggggc
     9541 gccggggtgg gcggctcctc ccccacggtg tccagccgta cccacaccag gacgccgtcg
     9601 tcgtgcaccg gcaggggttc ccacccggcg aacggggcgc cgtcgagggc gagtccgtgc
     9661 cagtggcaca cgagcgtgcc gcaccgcacc gggctgtcgg ccagcggggc gccgaggtgg
     9721 gggcaggcgc cggggccgcc caccagtcgc ccgtgcgcgt cccgccagac gacgacctcg
     9781 acgccggcga cggtgccgga gagcggacgg gtgggccgta cgccggtgct cgcgccgagg
     9841 acgtaccagt tgcccgaagg gcgggccccg gcgcgccgga gggccgcggc gacgacggcg
     9901 gggcgggcct cgcgccacgt cgggcgctgc cgctcccagg ggagcgcacg gcgccgcagc
     9961 cgcaggggga ggcgtcctcg gcgggggtgg tcgtccgtgc tcatccggac tccttcgcat
    10021 cgagggcggc gccgtacggc acggtcgtcg gcgtgggggc gcggcgtgcg ccgagccggg
    10081 cggcgagcac gcgtacgagc ccgtcggcgg cgacggccgc gcgccgccgg cggggcacca
    10141 ccgcgcgccg gtgcagcacc gcgtacccgc tcccggcgat ggtgtcgagg atgttccggt
    10201 agagcaggaa ggcggtgcgg atgcagggcc gcgccacggg gtcgagcatg gcgaggccgg
    10261 gttgggcctc gcggtagacg ccccgggtga ggtcctcggc ggcccgcagc gcggccgtga
    10321 tgcgtgggtc gtcgcggccg gtgcgcctgc tccacagcag caggtcccgc tggacgccgt
    10381 gcgcggccag caggtcggcg gggaggtaga cccggccccg gtccaggtcc tcgccgacgt
    10441 cgcgcaggaa gttggtgagc tggaaggcga cgcccagcgc ggcggcgtgc ggggcggccc
    10501 gggcgcggga ggtcacggtg ccgaggacgg ggagcatctg gaggccgatg accgcggccg
    10561 agccgtgcat gtaggcgcgc aggtcggcgt aggtggcgta gtccgtgacg gtgaggtcgg
    10621 cgcgcatcga ggccatgaag tcggtgaagt gcgccggttc gatggcgtac cgggcggcgg
    10681 tgtcggccag ggccagcacc acgggctcgg cggcgggacg gcccccggcg agcgcgtgcc
    10741 gcagcagccg gtcgaggcgg gcgagggcgg cggcgcgctc ggcgggcgtg gcgtcggccg
    10801 tgtcgtcgac gatgtcgtcg gcccaccggg cgaacccgta cagggcgtgc acggcgggcc
    10861 tgcggtcggc gggcaggagg cgggtggcca ggaagtaggt gcggccgtgg cgggcgttga
    10921 ggagccggca ccgggtgtag gcggcgcgca gggcggggtc ggtgacgccg gcggcgtcga
    10981 gttcgcgtcc ggtcatcgcc gcccgcccct cgccgcccgg aggcgcagcg gtgtgccggt
    11041 gatgcgggcg gcggccagct tcccggagac cagtacggtc ggcaccccga cgcccggggt
    11101 ggttccgcag cccgcgagga ccgcgttgtc ggtgccgcgc accaggttgc gggggcggaa
    11161 gggtccggtc tgggcgaagg tgtgggcgac cgagaacggg gtgccggcgg cgtgcccctg
    11221 agcggtccag tcggcgggcg tcaccaggca ctcctcctcc acggccgcgg cgatgccggt
    11281 cagtccccgg cgttccaggg tggcgagcag ccggtcgcgg tagcggggcg cgaggtcgct
    11341 ccaggcgcgg gcgccggggc cgatgtcggt gttggggcag ggcgcgagga cgtagtggag
    11401 gtggcggccc tcgggagcga gggaggggtc gtgggcggtg ggccgggtga tcagcaggga
    11461 ggggtcggtc atgagggtgc cggtccgggt gagttcgtcg aaggtccgac gccacgcggc
    11521 gccgaaggag agcgtgtggt gggcgaggtg cggccaggtg cgggtggtgc cggcgtgcag
    11581 cacgacggcc gagggtgcgt gccgcagggc gagggggcgg cgcgggcggc ggcccaggag
    11641 ccggtgcacg acgggcaggt cgggggtgag gacgacggcg tcgcacggga tgcgctcgtg
    11701 gtcggtgacg accgcggtga cgcggttgcc ggagcgctcc agacgggtga cggcccgtcc
    11761 gaggcgcagg tcggccccgg caccggcggc cgccgcggcc atggcgcggg gcagggcgtg
    11821 cacgccgccg cgcgggaagt agacgccggc gacggtgtcc atgtaggcga tgacggcgta
    11881 cgcggccagc gcgcgggacg gcgccacacc ggcgtacagg gcctggaagg agaagacccg
    11941 cttgagccgt tcgtcggtca ggaagcgtcc gatgcgggtg tcgaggcggc cgaagccgcc
    12001 gagggcggcg agccgggcca ggtcgggggt gagcaggccg agcggcgagt cgaagttggc
    12061 gtcgatgaac cggcgcatct gcacggcgta cagccgcccg agccagtcgc gcagccgccg
    12121 gtacccggcc gcctccccgg cgccggcgaa ccgttcgacc tccgtctcca tcgcgtcggc
    12181 gtcggtgtgg acgtccaggg cggtgccgtc ggcgaagcag gcgcggtagg cggggtgcag
    12241 gggcagcagt tcgacgcggt cgcgcagccg ttcaccgacg gccgcgaagg cctcgtcggc
    12301 caggtcgggc atggtcagca cggtcgggcc ggtgtcgagg cggtagccgc cgagttcgcg
    12361 ccgtccggcc cggccgccgg ggagcgggtc gcgttccacg acggtcaccc ggcgtcccgc
    12421 gcccagcagg tgcagggcgg cggagagccc ggcgagtccg gcaccgacga ccacgacgtg
    12481 gtcggtgcgc ccggtcaccg tccgcgtcat cgcgcgcccc ggtccgcggg cggtccgtcc
    12541 ggccggggga tgcggtgctc gaccgtgctg gggggcatgg cggggtcctc tcgtgtggtc
    12601 ggccccatgc cttcccccgt cgcctccggc gcgacgccgc ggggccccgg ttcccctccg
    12661 gcagtcaccc gcccggccgt accgggtccc cccggcgggt ccccgtctcg cgccgtccag
    12721 cgcgccgtgc gcccccgcgg acggcgccgg gcggaatact cccccggacc cggccggacc
    12781 cggcggatcc ggccggcggg cggcggaccc ggcggaccag gccggcggga aggaaaggag
    12841 gcggacgtgc tcgacgcgga catcgtggtc gtcggtgccg gggcggcggg gctctccctg
    12901 gtgcaccggc tcccggccgg cgcgcggcac ggggcggcgc cctccgtcgt cctcgtcgat
    12961 ccgccgccgg gaccgctgcg gcccgcgcgg cgcacctggt gcttctggga ggccggaccc
    13021 ggccgcttcg accgggcggc gacggcctcg tggcagtggc tgcgggtgca cggccgggac
    13081 gggagggccg tgcggcggaa catcgcgccg gcccgctaca agatggtccg ctcggacgac
    13141 ttcgaggcgc tggtggagcg ggacctgaag gaccgtccgg ggctgcggcg cgtcgaggcc
    13201 accgtcggcg cggtgacggg cctgccggac gccaccgtgc ggctggcggc cacggacgcg
    13261 gcgggcgcgc cggtcggcct gcgcgcccgc tgggtcttcg actcccgccc gccggaccgg
    13321 ctgccggccg cgcgcacccg gctgctccag cacttccggg gctggttcgt gcgcaccgag
    13381 cggccggtct tcgacccgga ggtggtcgac ctgatggact tccgcaccgt gcagccgcgt
    13441 cggggcctgt ccttcggcta cgtgctgccg accggacggc acaccgcgct ggtcgagtac
    13501 accgagttcg gcccggcgcc gctgacgacc gaggcgtacg accgcgtgct ggaggactac
    13561 acgcgccgcg tcctgcgcac cggcgcgacg gaggtcctgt ccaccgagca gggggtcgtg
    13621 ccgatgaccg acgccgtctt cgggcggagg gccgagggct gcgaccgggt cttccggatc
    13681 ggcgtcgcgg gcggtgcgac acgggcgtcc accgggtaca cgttcgccgc cgtgcagcgg
    13741 cagtccgagg ccgtcgcccg cgcggtgcgg gcgggccgcc gcccggtgcc gccggccccg
    13801 cacccggcac gggcccggtg gatggacgcg gtgctgctgc gcgccctgga caccggccgg
    13861 gtcgacggac ccgacctctt cttccgactg ttcgaccgcg tgcccgccgg gcggctgctg
    13921 cgcttcctcg acggccggtc gcggctgtac gaggacctgg cggtcggcgt gcgcgtcccc
    13981 gtcctgccga tgctgcgcac ggcggccgaa ctgccgtggc tgccacgccg ccacctgccc
    14041 gtccgctgag tcccacccgc cgagtaccga cccgcccggg agccctggat gtccttgccg
    14101 cgcgccaccg cgccgaccac ccgccccgac cgcccggcgg gccgccgcgg ccgccgcgtc
    14161 gcccccgccg cggcccgttg caccccaccc ggccgcgtct cccgccggcc gggcgccgcg
    14221 ggcggtggtg ccggacgccg ggtgccgccg ggcccggact gcggcacgag tccccggacc
    14281 ccgaccatga ccacgaccac gagtcccccg gccccggccc cagccccggg cccgacggcg
    14341 tccctcccct gcgccgagac cgccggccgg gtccgtaccg cccgggacgc gcggtgatcc
    14401 ggggcggtgg ggtgcggccg cccgggcggg accggcgggc gcggatgctg ccggccgggc
    14461 cgggccggga gcgggtcgag ggcgacgcgc cgtccgtggc ggtggtcggc ggcggcatcg
    14521 cggggctcgc ggcggcgacc ctcctggccg agcgcggggt gcgcgtcgtg ctccacgagc
    14581 gcgagcccgt gctcggcggc cgggtcgcgg gccggacggt cgccctgccg gacggcacgc
    14641 ccgccacgat gagccgcggc ttccacgcct tcttccgcca gtactacaac ctgcggagcc
    14701 tgttgcgccg gtgcgatccc ggcctcgcca tgctgaccgg gctgccggac taccccctgc
    14761 ggcacagcag cgggctgcac gacggcttcc gccggattcc gcgcactccc ccgttcagcg
    14821 ccctcgcctt cgtcgccctg agtcccagtt tcgggctgcg ggacctgacg gcgctgcggc
    14881 cgtccgccgc gctgccgctc ctcgacgtcc gtacccgccg cgtccacgag cgcctggaca
    14941 ccgtcagcgc agccgacttc ctcgacgcgc tgcgttttcc cgcggcggcc cggcacctgg
    15001 ccttcgaggt gttctcccgc agcttcttcg ccgaccctgg cgagttgtcg gccgcggaga
    15061 tggccctgat gttccacatc tacttcctcg gctccagcga ggggctgctg ttcgacgtgc
    15121 cgcgcgagcc gttcccgcag gcgctgtggg accccctcgc cgggcacctg gtgcggcacg
    15181 gggtcgagat ccgcacgagc acgtccgtcg aggccgtccg gcccggaccg tccggcgggc
    15241 ggctcgtggt cgacgccgcc ggggcccggc cgtacgacgc ggtggtgctc gcgatggacg
    15301 tcggcgggct gcggggcgtg gtgagccgct cgccgcacct gggggacgcc ggctggcggg
    15361 cgcgggtggc acggctgcgc aacgccccgc cgttcctggt ctcccggctg tggctggacc
    15421 gcccggtcgc gcccggccgg cccgggttcc tcggcacgag cggctacggc tcgctggaca
    15481 acgtcagcgt gctgtcccac tgggagggcg aggcggcccg ctgggcggcg cgcaccggcg
    15541 gctgcgtcgt cgaactgcac gcctacgccg tgccgtcgca ggccgtccgg gaggtcgagg
    15601 agaagcgtct cgtcgaccag ttgcaccggg tgtacccgga gaccctccgg gcccgcgtgc
    15661 tcgccgcacg gcacgagtgg cgggcggact gcccgctgtt cgccgtcggg ggttacggcg
    15721 accgccccac ggtgcgcacc cccgacccgg ccgtcgtggt cgccggggac ctggtccgta
    15781 cggatctgcc ggtggcgttg atggagcgcg ccgccacctc cgggttcctc gccgcgggcg
    15841 cgctgctgga gcggtggggg gtgcggggcg agacgctgtg gacggtgccg gaccggggcc
    15901 ggtccgcgcc gttgcgggcc ctggcacggc ggttcggggc gtactgaggc ggacggcgcc
    15961 gcggcggctc ggggcgcacc ggcacggacg gccacggcgg gccgcacggg gcgccgcccc
    16021 cgaatcggcc gtcgcgtccg gggcccaccg tcgtggaacc ggccgcggcg gcggggcgct
    16081 tcgccgccgg gcccggccgg ggtcccgtcc cgggccccgc ggcggctagc gccccctgtc
    16141 cgccgcgcgg tcggccagtc cgcccgcgcc gagcgggccg gtgtggccga gcggctcctc
    16201 ggcctccatc cgcggcagtt cgtggcggga cagccgtacg accgccggcg gcagcgccgc
    16261 gcgtccccac tggaccaggc gcagccagcc cggcacgtac acggcggtac ggcggcgctc
    16321 cacggcgcgg accagccggg ccgcgacgtc ctcgggcggg aacgtgcggc gggccggcgg
    16381 cggcatgtgg gcgcgcagtc cgcgcaggac cgggtaccgg tcggcgtcgc ggatcatgtc
    16441 cgtgtccatc cagttgaggt aggcggtgcc cacggcgacg ccgcggtggg ccacctcggc
    16501 gcgcagcgag tgggtgaagg cctccacgcc ggccttggcg gcgcagtagg cgctcatcat
    16561 gggggcggcg ccgagcgagg ccagcgaggc gatctggagg tggtagcccg cggtgtcgag
    16621 caggtccggc aggaaggcgc gggcggtgtg ggcgctgccg gtcaggttga cgtccacgac
    16681 gcggcgccac tcggcggggt ccgaggtggc gaacggtccg ccgtgggcga tgcccgcgtt
    16741 ggccaccacg accgacggcc tgcccaggcg ccggcgggtc tcctcggccg cgtcggccag
    16801 cgcggcgggg tcggtgacgt cggtctcgac ggcgagcgcc ggggtcggca ggtccgccgc
    16861 cagggcgtcc agcagcggct tctccaggcc gagcagggcg agccgggcgc cgcggcgggc
    16921 gcaggcgcga gccagggcgg cgcccagtcc gcgcgcggcg ccggtcacca cgacggtgcg
    16981 gtggtcgagg ggactgtcgt tcacgggtcg gccctttcct cgggtcctcg gagtcgtccc
    17041 ggaccgggcg ggcgcccgac cgcggtcagc accggtcgcc ggtccggtcg cgtcgggtca
    17101 gggaccgctg caggcgggcg aggcccgcga accggtgctg gcgcagggcg gcgcgcgcgg
    17161 cgttggcgcc gggcgcgccg tgcaccccgc ctcccgggtg ggcgcccgcg gaggcgagga
    17221 agagaccggt caccggtgtc tccggccgtc cggtgccggg cacgggccgg aagacgagct
    17281 gctggtgcat ggcggtggtg ccgccgttga tggcgccgcc ctccaggttg gcgttcatgg
    17341 cctggagggt gggcggggcc agcacgcgcc gggcccggac cagggcgcgg aatccgggag
    17401 cgaaccgttc cacctggcgt tcgacccggt cggccatcag ctcctgctcc cgccggtccc
    17461 agctcccggt gacgccctcg tcccccgcgt cgccgcggat gtcgtgcggg acgtgggtgt
    17521 aggcccaggc ggactcggtg ccggccggtg agcgggtcgg gtcggtggtc gtcatctggc
    17581 cgaagagcga gaaggggcgg tcggggacct gccgcatggc gatctgggcg gcgaaccggg
    17641 tcagttcgtc gaggccgtcg gagaggtgca cggtgccggc ccccgccgcc tcctcgcagc
    17701 gccagggcac ggggccgtcc agcgcccagt cgaccttgaa ggtggcgaag tcccactgga
    17761 agcgccgcag gtccctgcgg acttggtccg gcaggtccgc cggggcgacg agccggccgt
    17821 acagggcggg gacggagacg tccgcgagga cggcgcggcg ggcggtgacg gcgtccccgt
    17881 cggcggtgcg cacgccggcc gcgcgccggt cgcggaccag gacgcggtcg acgcgccgtc
    17941 cgcagtgcag ggtgccgccc cgggcgcgca ggcggcggac cagggcctcg gtgagggcgc
    18001 cggagccgcc gaccggcacg gggaagccgt aggtctgtcc gagcatcgac atcagccagc
    18061 cgaagccgcc gctgccggcc gcctcggggg cgaggtcggc gtgcagggcg ttgccggcca
    18121 ggagcagtct gccgccctcg ccgcggaact cctcctcgcc catgcggcgc acgggcagga
    18181 ccagggtgcg ggcgagcctg agtccgcccg cgccgcgcag ccgcagggcc agccgggcac
    18241 cggcgcgcac gggcgggaag ggggtgaaca gggcgtccac gatgtcggcc cggtagcggt
    18301 cccacaccgc gtggagccgt tcccaggcgg cgccgtcccc gggggcgaag gcgtcgagcg
    18361 acgcggcggt ggtggcgagg tcgcggtcga ggacggcaca ggtgccgtcg gtcagggggt
    18421 gggcgaggac gtggggtgcg tgcgcccagc gcagcccgtg ctcctccagg tggagtccgc
    18481 cgaggaccgg ggaggcggcg gccagcgggt agaaggagct gaacaggtcg ttgacgaagc
    18541 cgggggcgac cgcgtcgtcg tgccgcaccg cgccgcccgg ctcgggctgc tcctccagga
    18601 ccgtcacgct ccagcccgcg tcggccagca ggttcgccgc caccaggccg ttgggtccgg
    18661 ctcccaccac gacggcgtcg acggcgtcag gcacggccgc ttccccgccg gtggtgcacc
    18721 gcgcccaccg tgtcgggcgg gtcggggcgg caccggtcgc cggcgcggga ctcgcacagc
    18781 ttggcgagtc tggcgagcat ggcgcggtgg cgcacctgga tcagggcctc gacgccgacg
    18841 ttgtgcagca ggcccccggg gccgcgcagg gggtgctcgt ccacgatcac caggcactgc
    18901 tcgccccacg ggcgcagttc gacggcgatc cgggcggtgc cgagccggcc cgccttggcc
    18961 tccagctcca gcacggagcc ctccacgcag cgtctgacca ccgactcgtt gtcgagcagc
    19021 agcggcccga gccgcacctc gtacgcgatg gtcgccccga cctgcggcca ccgcccgtcc
    19081 ctgggggtga ccttcgaggg gccgaccacc cactgcacgt aggcgtcgcc gtccgcgagg
    19141 acgtcccaga cggcctgcgg ggtcgcctgg atcagccggt gccggatcgc cacgtgtgcc
    19201 tcctacgtcc agtggccgct gcgggccgtc gttgcgcgga cggagcctga gtgccccgtc
    19261 ggcggccgcc caaccgggcg aagggggcga aacgaccggg tgcgcggacc ggcggcagga
    19321 aaggcggcgc ggaaaggccg tgcattggca tggacctgaa gacatgggct ggctacgctc
    19381 gaagcaaccc gatgagagcg ctctcacacc gcggttgttc cgtgtcatct gttccacccc
    19441 cacctttgct ggaacgacga agggcaactc cgtgagacgc agcagactca ggcacctcgg
    19501 cctggccgga ctcctcgtgc tcggcagcct caccgcggtc ggcaccctgc cggcctcggc
    19561 ggccggggcc cccgccgcct ccgtcgacga acggccggcc tccgccggcc ttctggacgc
    19621 catgcagcgc gacttcggcc tcacccggga ccaggccgag gaccggctcg cggccgaacg
    19681 cgacgccacc gaagtggaac cggtggcgcg ccgggccgcc ggagcggcct acggcggctc
    19741 gtggttcgac gccgacaccg gcagactcac cgtggccgtc acctccgacg cggccccctc
    19801 gacgctgagc gcggtgcgcg ccaccggtgc acaggtgcgc accgtcgagc acagcgcgcg
    19861 gcaactggac gcggccaagg cgcgcgtcga ccgcctcgac gcccccgcgg gtgtcagcgg
    19921 ctggcacgtc gaccagcgcg ccggcaccgt ggtcgtcgac gtggtcgcga gcgagcaggc
    19981 tgacaacgat gtccagcgct tcctgaagca ggcccgcgag accggtccgg tcacggtgcg
    20041 cgcggtgccg tcggccccgg ggaccttcgc cgccggcacc gtcggcggcg acccgtacta
    20101 caccggcaac gtccgctgct ccatcggttt ctcggtgcac ggcgggttcg tcaccgccgg
    20161 gcactgcggc cgggccggcg ccggggtcag cggctgggac ggctcctaca tcggcacgtt
    20221 ccagggctcg tccttccccg acaacgacta cgcgtgggtc agtgtgggca gcggctggtg
    20281 gacggtgccg gtcgtgctcg gctggggcac ggtctccgac cagctcgtgc gcggctcgaa
    20341 cgtggcgccc gtgggtgcct cgatctgccg ctccggctcc accacgcact ggcactgcgg
    20401 caccgtgctg gcccacaacg agacggtcaa ctacagcgac ggctcggtgg tgcaccagct
    20461 caccaagacc agtgtgtgcg ccgagggcgg cgactccggc ggctccttca tcagcggtga
    20521 ccaggcgcag ggcgtcacct cgggcggctg gggcaactgc tccagcggcg gggagacctg
    20581 gttccagccg gtcaacgaga tcctgaaccg ctacggcctg accctccaca cggcctgacc
    20641 gggcggggag ggccggtccg cgccggctcc ggccctcccc ccaccgccgg tgtcccggac
    20701 cgcgccacgg ctccggggcc cgaacgggct cagacgtcgc cgggaccggt ccccggctcc
    20761 ggcgcgtcgg ggcccgtcgc cgtggtcagc cggcggtagg cggcccgcgc gtgcaccaga
    20821 cgggccagtg ccgtaccgac gagggccgcg ccgagcaggc aggcgagcca gaacgcgtcc
    20881 cgccggccgg cccacgtgag ggtgccggcc ggcggtatgg cgaagccgtt gagggacagc
    20941 cagcacagca cggccgtccc cggggcggcc gcgaacggcg cgcacaggcc gagcagggcc
    21001 gccagcagcg agagcgcgac cagggcgaga cccgggcgtc ccgagccgac ggtgccgttg
    21061 aggagcccca ccagcaggag ggcgccgccg aaggctccgg cccacaccag gggagccgcg
    21121 accggccggg gaacgggtct ggcaccgctg cccaggggca cccactcgat catgctgact
    21181 ggctccttcc ggtcccggac gcgtccggcc gcggcggcgt gacaacggtc ctgtgggcag
    21241 attgtcccac cgggaaccgc ggggcaccgc gccgaggcgg aggtgctcag cgctccgtct
    21301 tcgcgtgttc cggggaggag gtcccggagc cggacgagca ggaggccccg gctggcaccg
    21361 gacggctgtc cgcgtccgtc ccctcatccc ccgcaccgct cccgtcgccg ggcgccgcgg
    21421 ccggtgccgg ggccccgggc agcagccggc cggcggcccg cagcgcaccg gcgagtacgt
    21481 gggcgcgccc cgcgacgacg ggtccgagga cggcgaggac gagcacgtac ccggcgatga
    21541 agggggcgag ccgcgcgtcc agtccggcgc ccgcggccat ggcggccagg atcagcgcga
    21601 actccccccg ggcgaccagg gtggtggcga tctccgcggc cggttcgctg ccgtagcggt
    21661 acacccgggc gacgcacagt cccgcgacga cgttcatgac gacggtcagg gccgcagcgg
    21721 cggcgaccgg accggcgacg gaggcgaggt cgccggggtc gatggcgagg ccgaaggcga
    21781 agaagaaaat ggccgcgaag gcgtcgcgca gcgggtgcac cagctcccgg atccgcggcc
    21841 ccgagggggt gccggcgagg atcaggccca ccatgaaggc gccgatcgcg tcggcgacgc
    21901 cgaggagttc ggagaccccg gcgacgagca cggcggcgcc gaggaagctg atgacgagca
    21961 gttcgttgtc ccgcgtgtgg atcagccggc ccacgagccg ggtgccgtag cgggcggcgg
    22021 cggccagcac cagcaggaag ccgaaggcct tgccggcctg cagcgccatg tcggccacgc
    22081 cgtgcgcgcc cgagatgacc ggttgcaggg cggccaggta cagcgcgagg aagatgtcct
    22141 ccacgacgat gacgccgagg atcagccggg tctccggacg gccgatccgg cccaggtcga
    22201 tgaggatctt ggtgacgatc gcggaggagg agatcccgag cacgcccgcc aggaccagcg
    22261 cctcgcgcac gccccacccg aggacgaagc cgaagccgag cccggctccg acgttcagga
    22321 gcagatacac gcccccggcg gtcagcagcc gtttgcctcc gctcttgagg tcgtcgaggt
    22381 ggaactccag ccccaggtag aagagcagca gcacgagtcc gagcgcggag agcatctcga
    22441 agtcgtgcgc gtcctccacc aggacgaagc ccggtgtgtg cgggccgagc aggatgccgg
    22501 cgagcatgaa cagggggatc gtcggcagtc cgatcctgcc gccgaggcgg gcgaggaacg
    22561 cggcggccac gaaggcaccg cccatggcga gcagggtgtc agcgtgtccc acgggtcacc
    22621 gccttcactc gcgcgcaggg tcggacgggc ttcacttgac ggggatggat gcgcattctc
    22681 cttcgtcggt cgtgcgtcgt cgggtgatac gtcgtcaggt cgtgccggtc gggtcgtgtg
    22741 cggacgtgcc gcagccgtcg tgcggcacgt cgtcgtgccg cacgacgccg tgtcgtacgt
    22801 cgccagggca cacgtcttcg tgccacacgt cgtcgtgccg catcgtcgta ccgggccggg
    22861 cggccccgga ccgccactcc cctgtggcgt gacaccgctc gggggcggga aacccgcggg
    22921 ccgcaagcgg cccgcgccgt cgccaccgtg cccgtcggcc gaccggtgcc cgggcgggca
    22981 cagcacctcc gcgccggacc atgcggcacc gcccgcgaac gggcgggaca gggcttgtgc
    23041 gaaaacgccc cccggccccc gggaaagacc cccggggcgc ggcgtcggtc cactgtcaca
    23101 cgctctgccg cagcgcggcc atcggggacg acacccaaat gctccggcgg ccgacaccca
    23161 tcggcgggcc gggtgggaag gccgctcggc ggccggagga ggaggcgccg cggccgactc
    23221 ggggatcccg gccgcggcgc accctgccgc cccgtgcgcg ggaggacggc gcgcggcggg
    23281 gcacgaccgt gcgtcttccc cggcgtcccg tcatgactct gcgccaaccg agtgatcgtc
    23341 gggggacgtg tccgggctcc ggtccccgtc acggcgtccg ccccgccgct cggggcgacg
    23401 gggcggacgg tttgcggacg gtccgtcagc acggtgtggt tgccatcaac ttctcgaagg
    23461 aagccatgca gtccgggcaa tgacgcgccc gttcaccgtc ggatgcttct ctgcgttcgc
    23521 ggagctgctg tccgcagagt gtggccgcgg cctgcttgga cagtacgtgc cacaccaacg
    23581 ctccgcccgc cttctccggg cccacgcaca tttcgtacat gatcggcctc ccagcctgga
    23641 cgccgctgac actcaccagg agacaccggt tcggccgtga ccagtagcga gcggggtcca
    23701 ttcgggtgac ggccggttcg gccgcccggg acccgggcgc acccggacgg ctgcaaacga
    23761 tcagccaacc ggccctgaac gggtgcgcgt gacgtgtcgt cagggtgcgc gtacgccggt
    23821 gacgacgaag ccgctgcggg gccgggtcgg gacgcggcgc agcgggatgc gcagatcctg
    23881 ctcggggacg gtgcagtcca ggcgtgccaa ccgcaccgcc agcgcctgga gcaggccgac
    23941 ggtgacgcgc tcgccggggc agcggtggcc ggccgcgggg tcgccgccgc cctgggggat
    24001 cagctcgtcg gggccggggg gccggtccag gaaccgttgg ggccggaag
//
