LOCUS       NZ_BBOK01000014        23852 bp    DNA     linear   CON 17-AUG-2024
DEFINITION  Streptomyces sp. NBRC 110030, whole genome shotgun sequence.
ACCESSION   NZ_BBOK01000014
VERSION     NZ_BBOK01000014.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. NBRC 110030
  ORGANISM  Streptomyces sp. NBRC 110030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Katano-Makiyama,Y., Hosoyama,A., Hashimoto,M., Tsuchikane,K.,
            Uohara,A., Kitahashi,Y., Ohji,S., Ichikawa,N., Kimura,A.,
            Yamazoe,A., Komaki,H., Igarashi,Y. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Streptomyces sp. NBRC 110030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 362492)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 97x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417675.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,152
            Genes (coding)                    :: 7,019
            CDSs (with protein)               :: 7,019
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 45 of 133
            Pseudo Genes (incomplete)         :: 107 of 133
            Pseudo Genes (internal stop)      :: 8 of 133
            Pseudo Genes (multiple problems)  :: 23 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:33:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 241317
            Orig. end                         :: 265169
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBOK01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23852
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23852
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23852
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13852](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13852)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(213..971)
                     /locus_tag="APK71_RS30680"
     CDS             complement(213..971)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978509.1"
                     /locus_tag="APK71_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_055469626.1"
                     /transl_table=11
                     /translation="MIKPSADTTVVSRPRRRRPPLAAAVVQSLATAIVLGEYPPGTALP
                     SAEELGEAYEVSRTVIREATTTLAEKGLVATRQGWGTVVLGQDQWSLLDPLVLDALFQR
                     EDRLVYLDNLIEIRTTLECAMATRAAGRIDEEQSAALAAKLDELAGLIDDPEAYSRADI
                     EFHEIIHRASQDAFGRAIVSSVQGKAVRSPQYSGDPTREDIELTHEGHARVAAAVLAGD
                     GDAAAEAMREHITSSWARRRPADVPDAQQA"
     misc_feature    964..979
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 23.04"
                     /tool="antismash"
     gene            1273..1395
                     /locus_tag="APK71_RS39275"
     CDS             1273..1395
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="APK71_RS39275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_267891051.1"
                     /transl_table=11
                     /translation="MTPPARGIEVDEERTVARAASGGRSLPSGPHVRPAEAGLK"
     gene            1850..3109
                     /locus_tag="APK71_RS30685"
     CDS             1850..3109
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125499.1"
                     /locus_tag="APK71_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfite oxidase"
                     /protein_id="WP_055469627.1"
                     /transl_table=11
                     /translation="MHTPESAYDRRRLRQWLSGEARADGVSRRDMLRLLTAAGLAGAVP
                     AALGAPAAAAAATAPGIVKPLPEDLFTVRGTNAETRFAALAGTGYHTPNDRFFVRNHTA
                     TPLLDAADWKLTVWGDGLLGHRSVDFSLADLKKLPSVTHSAFVECAGNGRSYFTSQQGQ
                     EAGGTAWTLGAIGVARWRGARLADVLRRAGLDRRAVDVLPRGLDDDYVTADGTNLGRVR
                     RPLPLSKALDDVLLAYEMNGAPLPPDHGHPVRVLVPSWIGIASVKWVGDIQVSAQPLYS
                     PWNTDFYRLFGDAHPEGGSAPLTRQTVKSAWELDGRTNLTAGVTHRLTGRSWSGAGGVV
                     RVDVSTDGGASWRAARLHDAPRRDGWVRWSTPWRPPSPGTYTLLARATDTAGRTQPDVT
                     VHNTQGYLFDAVVRHGVSVV"
     gene            complement(3179..4102)
                     /locus_tag="APK71_RS30690"
     CDS             complement(3179..4102)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091472.1"
                     /locus_tag="APK71_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_055469628.1"
                     /transl_table=11
                     /translation="MTVGVALNAGDVRNQVDATVELAREAEAAGLRSAWFGQTFGADSP
                     QLAAIVGREVPGLQVGTSAIPVFGRHPLLVSSQAQTAQAATYGRYHLGLALGTKLLTEG
                     GFGLPFERPIARLREFLTALRQLTRDGTADFRGELLTAVTPVPARVPGAEAGVPLLVAA
                     MGAQSLRVSGELADGILPYLAGPRALETHIVPALTAAAESAGRPAPRIVALVHGVVTDD
                     VAAVREKATGHLAFYEQIPSYARVIEQSGGRRASDVAVIGDEKTVAAEVRRYRDAGATE
                     VVFAGTEIAGEADRRRTWALLGDLAG"
     gene            complement(4204..5349)
                     /locus_tag="APK71_RS30695"
     CDS             complement(4204..5349)
                     /EC_number="2.3.1.31"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (63-368). E-value:
                     6.5e-25. Score: 80.1. Matches aSDomain:
                     nrpspksdomains_APK71_RS30695_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192288.1"
                     /locus_tag="APK71_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="homoserine O-acetyltransferase"
                     /protein_id="WP_079080710.1"
                     /sec_met_domain="PF00561 (E-value: 3e-34, bitscore: 112.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTVRTPSRVPLPPVSGAWREGDPPGRRQWFVRETPLRLEAGGRL
                     PRPRLAFETWGRLAPDGSNAVLVLHALTGDSHVAGPAGAGHPTPGWWDGLVGPGRALDT
                     DRWFVVAPNVLGGCQGSTGPSSPRPGGRPWGGDFPFLTQRDQVSLEAELADELGIARWA
                     LVVGGSMGGMRALEWAVSHPERTGALLLLATTAAASAEQIAWADIQLRAIRSDPHWRGG
                     HYHAGGRGPHEGLGLARRLAHVTYRSEPELQARFGRSAQDREDPWAGGRYRVGSYLDHH
                     AAKLVRRFDAGSYVVLCEAMNSHDIGRDRGGVQAALRRVTARTLVAGVDSDRLYPPAQQ
                     AELAAGIPTADVPRTIESPCGHDGFLVEVDQVAALVAELLP"
     aSDomain        complement(4246..5160)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS30695_Abhydrolase_1.1"
                     /evalue="6.50E-25"
                     /label="APK71_RS30695_Abhydrolase_1.1"
                     /locus_tag="APK71_RS30695"
                     /protein_end="368"
                     /protein_start="63"
                     /score="80.1"
                     /tool="antismash"
                     /translation="NAVLVLHALTGDSHVAGPAGAGHPTPGWWDGLVGPGRALDTDRWF
                     VVAPNVLGGCQGSTGPSSPRPGGRPWGGDFPFLTQRDQVSLEAELADELGIARWALVVG
                     GSMGGMRALEWAVSHPERTGALLLLATTAAASAEQIAWADIQLRAIRSDPHWRGGHYHA
                     GGRGPHEGLGLARRLAHVTYRSEPELQARFGRSAQDREDPWAGGRYRVGSYLDHHAAKL
                     VRRFDAGSYVVLCEAMNSHDIGRDRGGVQAALRRVTARTLVAGVDSDRLYPPAQQAELA
                     AGIPTADVPRTIESPCGHDGFLVE"
     gene            complement(5346..6710)
                     /locus_tag="APK71_RS30700"
     CDS             complement(5346..6710)
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (60-245). E-value: 1e-09.
                     Score: 29.9. Matches aSDomain:
                     nrpspksdomains_APK71_RS30700_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566160.1"
                     /locus_tag="APK71_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional o-acetylhomoserine/o-acetylserine
                     sulfhydrylase"
                     /protein_id="WP_079080706.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-09, bitscore:
                     29.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.1e-12,
                     bitscore: 42.0, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-07, bitscore:
                     23.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQQPIDSVTAGHTPDEEPSAPDTSAWSFETKQIHAGAVPDPATG
                     SRATPIYQTSSFVFRDTRHAADLFSLAEPGNIYTRIHNPTQDVFEQRVAALEGGVAAVA
                     LASGQAAETLAILTLAGAGDHVVASASLYGGTYNLFRHTLPRFGIEVSFVDDPDDAEAW
                     RAAIRPRTKALFAETLGNPRGNVLDVRAVADVAHEAGVPLVVDNTVPTPYLLRPLEHGA
                     DVVVHSATKFLGGHGTTIGGVVVDGGTFDFGAHPGRFPDFTEPDPSYHGLRYWPALGPG
                     AFAVKLRVQLLRDLGPAISPHSAFLLLQGVETLSLRIERHSANAQALAEWLEQRDEVAA
                     VHYPGLPSNRWYEAGQRYLPRGAGAVLSFELRAGAEAGKRFVDAVELFSHLANIGDVRS
                     LVIHPASTTHSQLDERQLEAAGASPGLVRLSVGLENLADLKADLEAGFRAAKGAS"
     aSDomain        complement(5976..6530)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS30700_Aminotran_1_2.1"
                     /evalue="1.00E-09"
                     /label="APK71_RS30700_Aminotran_1_2.1"
                     /locus_tag="APK71_RS30700"
                     /protein_end="245"
                     /protein_start="60"
                     /score="29.9"
                     /tool="antismash"
                     /translation="DTRHAADLFSLAEPGNIYTRIHNPTQDVFEQRVAALEGGVAAVAL
                     ASGQAAETLAILTLAGAGDHVVASASLYGGTYNLFRHTLPRFGIEVSFVDDPDDAEAWR
                     AAIRPRTKALFAETLGNPRGNVLDVRAVADVAHEAGVPLVVDNTVPTPYLLRPLEHGAD
                     VVVHSATKFLGGHGTTIGGVVV"
     gene            7160..7426
                     /locus_tag="APK71_RS30705"
     CDS             7160..7426
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384028.1"
                     /locus_tag="APK71_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_030400504.1"
                     /transl_table=11
                     /translation="MSVIGWLVLGLLAGGIAKLILPGRDPGGCIGTTVIGIAGAFLGGW
                     LSARFLDRPVQKEFFDAATWGSAIVGALVLLIGYRLLFGNSRD"
     gene            complement(7470..8645)
                     /locus_tag="APK71_RS30710"
     CDS             complement(7470..8645)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841294.1"
                     /locus_tag="APK71_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyltransferase"
                     /protein_id="WP_055469629.1"
                     /transl_table=11
                     /translation="MYTSTPRLRRLAWLDNLRIALTVLVVVHHAAQPYGPADWWYVEGQ
                     PRAGALATLSAVDGSFFMSLFFFVSAVLIPGSCERHGTRRFLRGRFVRLGIPVVVGALT
                     IVPGLMYAYFTHYRGYPPMPFTRYFTDVYLGMGEEPAGWSGPSWPDLQFGHLWFVQNLL
                     ACTVVYVVLRRLGRPLRVRRGPGRAVAPPGHRALVALTVLLAGATFLVRLRYPLDAWVP
                     VLDFLQVEPARVPQYAAFFALGVVAGRQDWLERFDTRVGLVWLAVGAAGVALLFLAGAD
                     SRWFGPGGADVPSAVWAVCESALCVSLCVGLLTLFREFVRGGARWSRELAASSYGVYII
                     HVPLVVAVQYALAGRGLSAAGSWCAAVVLALPSAFLLAAGLRRLPGLRRVL"
     misc_feature    complement(8638..8653)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     misc_feature    8658..8673
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            complement(8686..9309)
                     /locus_tag="APK71_RS30715"
     CDS             complement(8686..9309)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836649.1"
                     /locus_tag="APK71_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_055469630.1"
                     /transl_table=11
                     /translation="MRVEKGDLTGRARLRKAALELFAERGFEATSTRAVATAAGVSPAL
                     VTRHFGSKDGLRAAVDQDVLERIGGELADVDPDADLMESLGAVSARLFGADPVLRGYLR
                     QVLLEDGEAGAALFGKLLRGARTELERLSSVYGGARGGEEADSTWAPFQMLCLILGPLL
                     LERVMQPNLEEPMFAPEVLARRSAANQRLLVQGFYGCPEDRSGG"
     gene            complement(10001..13852)
                     /locus_tag="APK71_RS36870"
     CDS             complement(10001..13852)
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="APK71_RS36870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding protein"
                     /protein_id="WP_055469631.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-48, bitscore: 159.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /sec_met_domain="T2TS (E-value: 1.4e-44, bitscore: 146.6,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCAPDWAHAERRARAWAVAHHLVADGEEARRLARTGHGRMAGWLA
                     PGAGPAELALLAQWGAFIASVDDGFDRHGQSPEQAGAVLDELLAVLGGDDGTRCPPSAA
                     PVVRALADLWARTRIAARPGWRQRFRTLYRDFAEATVTELRLRSSGERLGLDDYVALRR
                     RTITVLPMLAVVERARPPAVELDGLRDAAADIVAWANDLRSARREADEGAENLVGVLAR
                     HHRCSPARAAAHARAMLAERMDEFDRAARGDRAAPIRRVRDGSLAWQRETHRNAAGGGF
                     LAADHERGVSALAQHLVVAVDAAGHVDDRCGSRVLESTLLLALLRAQGAEPDEQDRLAR
                     FLRRRRPGANDVDALLIDACLDPAGTAGRAPERAAALPLAMSSGTAGRGRLKSVMLRTV
                     LHLLCGSALESGDAPAPVAPAGLTTFTDVHLLSARIVHAHARHRPHEVTDAERNRLVSL
                     LARGRNRVLWEASATTHLLGLHAVRTFRPGDPVLDDGLLRLCLAVNTDDGVPFLDSQDL
                     WLTAVAGLAFTAEDSLARQVPRMADLVASWQAPDGGWPFATGMRQTDVDTTTRCMEFLH
                     AAGPDRYREVLDRAAGYLTGIAGPDGGFPTWVRGDTPDLDMTAGAVLALAPRAARHERL
                     LSGAIERVLEAQRPDGTFERSWTVSESSAVLRAVDALHAIPAADAGLAARIAAATARAA
                     RRLVATQRPDGGWGQVPGDPGDVLSTAQAVPVLARHGEPLAVGRALTYLLERQDSDGGF
                     TAPPDQVGPRPLPFDYPVLADIHTLSALRSVRVPAATAPRTPSPVPVKGSAGSAGSAGS
                     AAKWPALEAGLRGVLLRPEQAAYEQARLLVNQRFDGIRPQAIAYPADVHDVVECVDFAR
                     TSRVPLALRSGGHSYAGYSTGPGLVVDVSSLNSTAVGGGYARFGAGVKGQQAHLALAAA
                     GAGLPLGRCPTIGLAGVTLGGGLSAFTRAWGLACDHLREVEIVTADGRVRRVRADSPYP
                     DGDLFWALCGGGGGNFGAVTALEFATEDIRDLSCTRFLAGWPSAATAAVLRGWSVWNAD
                     PSTPRTVTCAFEQLSDSGLPSRPTVTGTFIGPPGALEPVLDRLAAAVGLPEAERVLVPC
                     DYTRAASEADRWGGGTLGPRVAFAAKSHIVREPLSPAAASDMAAALERLHRFTAVGGAG
                     GLLIDALGGAVGDRPPGATAFPHRAAVGVVQYHSYWHQFTDPAHVDARIEWLRDTHTTL
                     QTHLGTGGYTNGMDPELTDWQTAYHGENYPRMQRVKAACDPDHLFTFPQAVTSGTAGR"
     gene            complement(14043..14651)
                     /locus_tag="APK71_RS30725"
     CDS             complement(14043..14651)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388513.1"
                     /locus_tag="APK71_RS30725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_055469632.1"
                     /transl_table=11
                     /translation="MLPYRPGTHPAPGRQEWRQALIVLGCQLAAVGPRRHEDWLVDAAA
                     VLRFRTRDPRGWLPDAHSRWPERTGHSPYYPFDRLEPHHLDHHLELLTHEAAVELTALH
                     WTATPHGGAEPPGAADPVRRSRLWSAARTLLARFGPEAEYATNAEDLSGGTDPHWYRDG
                     FSLSCFAGVDAQRDGLITDFGILAVSETEVGAFWNFFVD"
     gene            complement(14711..15337)
                     /locus_tag="APK71_RS30730"
     CDS             complement(14711..15337)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327188.1"
                     /locus_tag="APK71_RS30730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_030400499.1"
                     /transl_table=11
                     /translation="MTAARGRTGRPPLTDERKAAIRLEIARAAVGLFVAQGVAATTGEQ
                     IGQAVGVSARTVWRYFPTKESCVRPLFSSGIDTIAAALREWRPGRPLQEAFDGVWADDQ
                     DLAGPDVGALLRLTRTEPGLRAVWLQTRDEAEPAFARALAERAGLPDDDVRPAVWAAML
                     NAALRAAVEHHAHRSAAPGSEAAPAHADLATTLRTALALAATGLT"
     gene            15478..16239
                     /locus_tag="APK71_RS30735"
     CDS             15478..16239
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-170). E-value: 2.2e-07. Score:
                     22.9. Matches aSDomain:
                     nrpspksdomains_APK71_RS30735_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068995.1"
                     /locus_tag="APK71_RS30735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_053639514.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-35, bitscore:
                     116.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMGVDGRSVIVTGAGSGIGRAAALAFAAQGDRVLVADLDAEGAA
                     ATVEEIERSGGTAVAVTGDLSEQAVVDRVTATAVERFGGVDVLVNNAGIMDSMSAAADV
                     ADAEWDRVIRVNLTAPFLLTRAVLPHMLAAGRGAIVNTASEAALRGSAAGAAYTASKHG
                     VVGLTKSLAVMYRKNGVRANAVCPGGTATAIAVEADPAAHGPAALGPHFVNLGRVSQPD
                     EQAAAILFLASEAAGNINGAILPVDDGWSAV"
     CDS_motif       15502..15585
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS30735_0001"
                     /evalue="4.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="APK71_RS30735"
                     /protein_end="36"
                     /protein_start="8"
                     /score="16.2"
                     /tool="antismash"
                     /translation="SVIVTGAGSGIGRAAALAFAAQGDRVLV"
     aSDomain        15502..15987
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS30735_PKS_KR.1"
                     /evalue="2.20E-07"
                     /label="APK71_RS30735_PKS_KR.1"
                     /locus_tag="APK71_RS30735"
                     /protein_end="170"
                     /protein_start="8"
                     /score="22.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="SVIVTGAGSGIGRAAALAFAAQGDRVLVADLDAEGAAATVEEIER
                     SGGTAVAVTGDLSEQAVVDRVTATAVERFGGVDVLVNNAGIMDSMSAAADVADAEWDRV
                     IRVNLTAPFLLTRAVLPHMLAAGRGAIVNTASEAALRGSAAGAAYTASKHGVVGLTKS"
     misc_feature    complement(15506..15526)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.79"
                     /tool="antismash"
     gene            complement(16299..18107)
                     /locus_tag="APK71_RS30740"
     CDS             complement(16299..18107)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978566.1"
                     /locus_tag="APK71_RS30740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_031082347.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.5e-11, bitscore:
                     35.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQAQELTPEVLAELRERYRRERERRVRPDGTRQYLGADAEFGYY
                     AADPYAAEAAGREPVRDRVDVAIVGGGFGGILAGARLRQQGIARVRVIEKGGDFGGTWY
                     WNRYPGIHCDIEAHVYLPMLDETGYVPEWKYAPGEEIRRHAVRIGEKFDLCADALFSTA
                     VTSLTWDDTDGAWIVGTDRHDEFRATYVITATGTLSELKLPGIPGIEAFRGHTFHTSRW
                     DYAYTGGTPDGGLTGLADKRVGVVGTGATGVQVVPKLAEDAGHLYVFQRTPSSVDVRDN
                     RRTTARDVGADRPGWARERRENFLRIVSGEATGEDLVADRWTASAGLLEKLLPSFRRTG
                     DRAAFEAAYEVADAVKMNEIRARVDDVVTDPETADRLKPWYRYACKRPTFSDLYLQAFN
                     RDNVTLVDTADTHGIERMTERGVVVGGTEYPLDCLVFATGFSVGVSGVHSGRLPVRGRG
                     GVLLRDAWSAHGPRTLHGFTSNGFPNLIQLGGTQSASSVNYTHVLDEHAVHGAALVAAA
                     EAKDALVEPSREAEDAWIAALAEHAPDHEWFHAECTPGYYNAEGRGRPNGPTAYPHGAV
                     AFHELLARWRKESMDEILSPRHPARG"
     misc_feature    complement(18203..18220)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.48"
                     /tool="antismash"
     gene            18280..19302
                     /locus_tag="APK71_RS30745"
     CDS             18280..19302
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971272.1"
                     /locus_tag="APK71_RS30745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SMP-30/gluconolactonase/LRE family protein"
                     /protein_id="WP_053639556.1"
                     /transl_table=11
                     /translation="MRRVPIRPLAGLVTLGVLALAGCGTQTAGAPRDPGTAEGDRTIRA
                     QQVMRVTEVHEQTGMTLLEGPVFDGDGRLLVVDVTAPAGEPKVLRVNVRKKTSEPVHTD
                     ARGAYTSAQFSPYDGRIYLTDFAHGDIVSLAPDGGDPRTFFSGEVDGARMNPDDLAFDP
                     EGHLYVSDSRGMSEGEAKGRVVRIERSGKDATVLADGLAAPNGISFDADYRGLWFSELT
                     QNRVSYLLLDGKGAVASRHTAVRVDAGIARTDSVAVDADGNLYQGLHGRPAMAVYDKYG
                     ERLATVEVPARDAAGLESATNVAITPGGTRAYMTVSGPDGGYLYAFEALGRGTRQSNGG
                     "
     gene            complement(19318..19911)
                     /locus_tag="APK71_RS30750"
     CDS             complement(19318..19911)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308150.1"
                     /locus_tag="APK71_RS30750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_031082343.1"
                     /transl_table=11
                     /translation="MTQHRMSGEQRPANEGPKAAARNRAALVAAAREIYSEHGLDAPLS
                     AIARRAGVGQGVLYRHFPDREAVADAVLEENVRQVEQAAAVPGTDLARVLGVLTWHLTE
                     SAAFIGILHADGAGSRSVVPPYARALSERVGRALRAHLPDGHRLAAGDDDLMIAVAMVS
                     GAVTGPTREERERRGRAAWRLLGVEVGPVLPFAG"
     gene            complement(20039..21838)
                     /locus_tag="APK71_RS30755"
     CDS             complement(20039..21838)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328142.1"
                     /locus_tag="APK71_RS30755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 35 protein"
                     /protein_id="WP_055469633.1"
                     /transl_table=11
                     /translation="MTTLSPAAVLTHADGTLLRNGRPHRLLAGSLHYFRVHPGHWADRL
                     RRLAALGLNTVDTYVPWNFHERTEGDIRFDGPRDLTGFVRLAQEEGLDVVVRPGPYICA
                     EWDNGGLPAWLTGTPGMRLRTSHGPFLAAVDRWFDELIPRIADLQAGRGGPVVAVQIEN
                     EYGSYGDDHAYVRHVRDALVARGVTELLYTADGPTALMQDGGALPGELAAATLGSRPAR
                     AAELLRSRRPGEPFFCAEFWNGWFDHWGEKHHVRPADGAAETVGDILDEGGSVSLYMAH
                     GGTNFGLWAGANHDGDRIRPTVTSYDSDAPIAENGALTPKFFALREKLTALDASGPPRP
                     LPADPPVLAPRELPVTRRAALLDALRAAAEPVSAPLPLSFEELSLASGLVLYEAEPLLP
                     PGTHELTVSGLHDRAQVFLDGEPVAVLDRENASFDVPGTGARVRLALLVENQGRINYGP
                     LLGQGKGILGGVRVERRLVHGWTMRALPLDRWTPRDAARAAAAAPADGRAGFATAVLPV
                     AEPADAWVALPGFGKGFLWVNGTLLGRYWEIGPQTTLYLPGPLLRPGDNTLTVLELERF
                     GDRVALRDRPDLGPPQEYVETFD"
     misc_feature    21946..21957
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(22923..22936)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    23072..23092
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.2"
                     /tool="antismash"
ORIGIN
        1 gagacgccgc cgaagttgcc gtcgatctgg aagggcgggt gcaggtcgaa gaggttgggc
       61 gcggtggccg aggcgtacgg ggccgcctgg gtcgcggagt ggaaccggca cgtcaccgcc
      121 gaggggatcg gccggccgtg accggctgaa cgcgacgagg cggccgggcg accggccgga
      181 cgacggtccc ctgaccgcct cctcgcagcg tcctacgcct gctgcgcgtc cggcacgtcc
      241 gccggacggc ggcgggccca cgaggacgtg atgtgctcgc gcatcgcctc ggcggccgcg
      301 tcgccgtccc ccgcgagcac ggcggccgcg acccgggcgt gcccctcgtg cgtgagctct
      361 atgtcctcgc gcgtcgggtc gccgctgtac tgcggcgagc gcacggcctt gccctggacg
      421 ctggagacga tggcccgtcc gaacgcgtcc tgggaggccc ggtggatgat ctcgtggaac
      481 tcgatgtccg cacgcgagta cgcctcggga tcgtcgatca ggcccgccag ttcatcgagc
      541 ttggcggcca gcgccgccga ctgctcctcg tcgatccgcc cggcggcacg ggtggccatc
      601 gcgcactcca gggtggtcct gatctcgatc aggttgtcca ggtagaccag ccggtcctcg
      661 cgctggaaca gggcgtcgag gaccagcggg tcgagcaggc tccactggtc ctggcccagc
      721 acgacggtcc cccagccctg acgggtcgcc accaacccct tctcggcgag cgtcgtcgtc
      781 gcctcccgga tcacggtccg gctcacctcg tacgcctcac ccagctcctc cgccgacggc
      841 agcgccgtgc ccggcgggta ctcgccgagc acgatggccg tggcgaggct ctggacgacg
      901 gccgcggcga gcggtggccg gcgtcgtcgc gggcgggaca cgacggtggt gtccgcagac
      961 ggcttgatca tctggtcaga gactccccat gctcgtgcag gctcccgccc ccgctgtcca
     1021 atgactccag gctagccgaa cacgccacgg tcatcactcg tatcacaagt cgcgactggc
     1081 cgtgggacgc gccggccggg agcgctggcc ttgggcacgg cctgccggtc agtcccgtcg
     1141 ggtacaacgc caacccggtc gcgcacgcgg cggccgccgt gcccagccac ccggtgaccg
     1201 aggtgcagga tctgtccctc ccggtcggac cgcgggtgga ccaggagatc accgacggcg
     1261 ggatcgtcct cggtgacgcc cccggcccgg gggatcgagg tcgacgagga acgcaccgtc
     1321 gcgcgggccg cgtcgggcgg gcggtccctg ccgtccggac cgcacgtccg cccggccgag
     1381 gccggcctca agtgacgcgg ggaccggtcg ccaacgcacg tgcgatgccg atgcgttgcc
     1441 gccggcctcc gttgttccac gcccgctgct cgacatgaga ggaagaggaa cggccttgcg
     1501 aggcacgtcg gaacggcggc cggcgcacgg ccccggaccg gcgtcatcct ccgtttgaca
     1561 caggggactt ggccactcct ttccgatcac gcgtcgtctc cgtacgatgg ccccatgttc
     1621 cgcagccgac gccgcctcgc cgccccgcgg tcccgcgtgc tcctctcgta cggctgttgt
     1681 tgatccgcac cgcgtagacg acgctgtccc gcgcccggtc cggagcgtgt ccaggcaccc
     1741 tcggacgacg cgtcgccgcc gttcctttcg tcccctccgg gacggccgcc cttcccttcc
     1801 ccgtccgctc ggggcacgtc cccgcgcccc ccgtgaaagg cagcccctca tgcacacccc
     1861 cgaatccgcc tacgaccgac gcagactgcg gcagtggctc tccggcgagg cccgggccga
     1921 cggtgtctcc cggcgtgaca tgctccggct gctcaccgcg gccggactgg ccggcgccgt
     1981 gcccgcggcg ctgggcgctc cggccgcggc cgccgctgcc accgcgcccg gcatcgtcaa
     2041 acccctgccc gaggacctgt tcaccgtgcg gggcacgaac gcggagacac ggttcgccgc
     2101 cctcgccggc accgggtacc acacgcccaa cgaccgcttc ttcgtccgca accacaccgc
     2161 gacgccgctt ctcgacgcgg ccgactggaa gctcaccgtc tggggcgacg gcctcttggg
     2221 gcaccgctcc gtcgacttct ccctggccga cctgaagaag ctgccgtccg tcacgcacag
     2281 cgcgttcgtg gagtgcgcgg gcaacgggcg cagctacttc accagccagc agggccagga
     2341 ggccggcggc accgcctgga ccctcggggc gatcggcgtc gcccgctggc gcggggcacg
     2401 cctggcggac gtcctgaggc gggcggggct cgaccggcgg gccgtggacg tcctgccccg
     2461 gggcctcgac gacgactacg tcaccgccga cggcacgaac ctcggccggg tgcgccgccc
     2521 gctgccgctg tccaaggcac tggacgacgt gctgctcgcg tacgagatga acggcgcacc
     2581 gctgccgccc gaccacgggc atcccgtgcg ggtcctcgtg ccctcgtgga tcggcatcgc
     2641 ctccgtcaag tgggtcggcg acatccaggt gtccgcgcag ccgctgtact cgccgtggaa
     2701 caccgacttc taccgcctgt tcggcgacgc ccaccccgag ggcggcagcg ccccgctgac
     2761 ccggcagacg gtcaagagcg cctgggaact ggacgggcgg acgaacctga cggcgggcgt
     2821 gacccaccgg ctcaccgggc ggtcctggtc cggcgcgggc ggggtcgtgc gggtggacgt
     2881 gagcaccgac ggaggcgctt cgtggagggc cgcccggctc cacgacgcac cccggcgcga
     2941 cggctgggtc cgctggtcga ccccctggcg cccgccgtcg ccggggacct acacgttgct
     3001 ggcccgggcg acggacacgg cggggcggac ccagccggac gtcaccgtcc acaacaccca
     3061 gggctatctg ttcgacgcgg tcgtgcggca cggcgtcagc gtggtctgac gctccggcgg
     3121 gtgcggtggg agccccgggc cccgtacggc ggcccggggc tctcgccgag gtgctgtctc
     3181 agccggccag gtcgccgagg agtgcccagg tgcggcgccg gtcggcttct ccagcgatct
     3241 ccgtgccggc gaagaccacc tccgtcgctc cggcgtcccg gtagcggcgt acctccgccg
     3301 cgaccgtctt ctcgtcgccg atcaccgcca cgtcggacgc ccggcgtccc ccggactgct
     3361 cgatgacgcg ggcgtaggag gggatctgtt cgtagaacgc caggtgcccg gtggccttct
     3421 cccggaccgc tgccacgtcg tccgtgacga cgccgtgcac cagggcgacg atcctcggcg
     3481 cgggccggcc ggcggactcc gccgcggcgg tgagggccgg gacgatgtgc gtctccagtg
     3541 cgcgggggcc cgccagatag ggcaggatgc cgtccgccag ttcgccgctg acccgcaggg
     3601 actgtgctcc catcgccgcg accagcaggg ggacacccgc ttccgcaccg ggcacgcggg
     3661 cggggaccgg ggtgacggcc gtcagcagtt cgccccggaa gtcggcggtg ccgtcccgcg
     3721 tcaactgccg cagtgcggtg aggaattcgc gcagccgggc gatgggccgt tcgaagggca
     3781 ggccgaagcc gccctcggtg agcagtttgg tgccgagcgc cagtccgagg tggtagcggc
     3841 cgtaggtggc cgcctgcgcg gtctgggcct ggctggagac gagcaggggg tgccgtccga
     3901 agacggggat cgcggaggtg cccacctgga gtccgggcac ctctcgtccg acgattgcgg
     3961 cgagttgcgg cgagtccgcg ccgaaggtct ggccgaacca ggcggagcgc agcccggcgg
     4021 cctcggcctc gcgggccagt tccaccgtgg cgtcgacctg gttgcgcacg tcgccggcgt
     4081 tgagtgctac tcctactgtc atgtcggtcg aacctccggt gtccgatgcc gattccggtt
     4141 cccgtgtgac ggcttcttgt cagtcgtgtg accgggggag ccccggttcg ggccgtgccc
     4201 gcctcacggc aggagctccg ccacgagcgc ggccacctga tccacctcga cgaggaagcc
     4261 gtcgtggccg cagggcgact cgatggtccg cgggacgtcg gccgtgggga tgcccgccgc
     4321 cagctccgcc tgctgcgcgg gcgggtagag ccggtcggag tcgacgccgg ccaccagggt
     4381 cctggcggtc acccgccgca gcgcggcctg cacgcctccc cggtcccggc cgatgtcgtg
     4441 actgttcatg gcctcgcaca ggacgacgta gctgcccgcg tcgaagcggc gcaccagctt
     4501 ggcggcgtgg tggtcgaggt aggagcccac ccggtacctg ccgcccgccc aggggtcttc
     4561 ccggtcctgt gccgagcggc cgaagcgggc ctggagctcc ggctcgctgc ggtaggtgac
     4621 gtgggcgagc cgccgggcca ggccgagtcc ctcgtgcggt ccccggccgc ccgcgtgata
     4681 gtggccgccg cgccagtgcg ggtcggagcg gatggcgcgc agttgtatgt cggcccaggc
     4741 gatctgctcg gcgctcgcgg ccgccgtggt ggcgagcagc aggagcgccc ccgtccgttc
     4801 gggatgggac acggcccact ccagcgccct catcccgccc atcgaaccgc ccaccaccag
     4861 ggcccagcgc gcgatgccca gctcgtccgc caactcggct tccagggaca cctggtcacg
     4921 ttgtgtcagg aaggggaagt cgccgcccca gggccgtccg ccggggcgcg gcgaggaggg
     4981 cccggtgctg ccctggcagc cgccgaggac gttgggggcg acgacgaacc accggtccgt
     5041 gtcgagcgcc cggccgggcc cgacgagccc gtcccaccat ccgggagtcg ggtggccggc
     5101 gcccgcgggc ccggccacat gactgtcgcc ggtgagggcg tgcaggacca gcacggcgtt
     5161 ggagccgtcc ggtgccaacc gcccccaggt ctcgaacgcg agccgtggcc ggggaagtcg
     5221 gccgcccgct tccaggcgga gcggcgtttc gcgtacgaac cactggcgcc gccccggcgg
     5281 gtccccctcc cgccaggccc cggagaccgg cgggaggggg acccgggacg gcgtccgtac
     5341 ggtgttcagg acgcaccctt cgcggcccgg aacccggcct ccaggtcggc cttgaggtcg
     5401 gcgaggttct ccaggcccac cgagagccgc accaggccgg gcgaggcgcc cgcggcctcc
     5461 agctgccgct cgtccaactg gctgtgggtg gtggacgccg ggtggatgac gaggctgcgg
     5521 acgtccccga tgttcgcgag gtggctgaag agttccaccg cgtccacgaa ccgcttgccg
     5581 gcctcggccc cggcgcgcag ttcgaaggag aggacggcac ccgcgcctcg cgggagatac
     5641 cgctgcccgg cttcgtacca ccggttggac ggcagtccgg ggtagtggac ggcggcgacc
     5701 tcgtcgcgct gttccagcca ttcggccagc gcctgggcgt tcgcggagtg ccgctcgatg
     5761 cgcaggctca gggtctccac gccctggagg agcaggaagg cggagtgcgg ggagatggcg
     5821 gggccgaggt cgcgcagcaa ctggacccgc agcttgacgg cgaaggcgcc gggaccgagg
     5881 gcgggccagt accgcaggcc gtggtagctg gggtcgggct cggtgaagtc ggggaagcgc
     5941 ccggggtggg cgccgaagtc gaacgtgccg ccgtcgacga cgacgccccc gatggtggtg
     6001 ccgtgcccgc cgaggaactt ggtggccgag tggacgacga cgtcggcgcc gtgttccagg
     6061 ggccgcagca ggtagggcgt gggcaccgtg ttgtccacga cgagcgggac gccggcctcg
     6121 tgcgcgacgt cggccacggc ccgcacgtcg agcacgtttc cgcgtgggtt gcccagcgtc
     6181 tcggcgaaca gtgccttggt gcggggccgg atcgccgccc gccaggcctc ggcgtcgtcc
     6241 gggtcgtcga cgaaggacac ctcgatgccg aacctgggca gggtgtgccg gaagaggttg
     6301 taggtgccgc cgtacagcga ggcgctcgcg accacgtggt ccccggcacc ggccagcgtg
     6361 aggatcgcca gggtctccgc cgcctgcccg gaggccaggg ccaccgccgc gacaccgccc
     6421 tccagcgcgg cgacgcgctg ctcgaagacg tcctgggtgg ggttgtggat gcgggtgtag
     6481 atgttgcccg gctcggcgag cgagaagagg tcggccgcgt gccgggtgtc ccggaacacg
     6541 aacgacgagg tctggtagat cggcgtggcg cgggagccgg tggccgggtc cggcacggcg
     6601 cctgcgtgga tctgcttggt ctcgaaggac caggccgagg tgtcgggcgc ggacggctcc
     6661 tcgtcgggcg tgtgaccggc ggtgacggag tcgatcggct gctggctcat ggtgctgctc
     6721 ccttgcgcgg aggacgggtg cgggaaggcg caccgcgcac ggcgacggac ctcggacgag
     6781 gccggtcgtc ggtgcggcgc ggtgcggtgc ggtgcgacgg gaggggacgg cgcagttggt
     6841 gcgcgagagg gacgtcggtg ctgaggaccg gcgtcagccc tgggcggtac agcccgtggt
     6901 ggtgacgcgc acgtagtcga cgtggcggcg ggtcacgagc acggtcatga gcccaggtaa
     6961 ccacatccgc gaagcgccgc accgcccctt gggcgtcgat ccggcggtcc gccacacgtc
     7021 cgcaacacag ccgtcatgaa cggggcccgg acggccctcc cgccgacccc gatcctctac
     7081 acgcttgtag aagataggct gtccgggcta cggctcacga acagaaacac gaacaggaat
     7141 acggaaaggg gcgccggaga tgagcgtcat cggctggctg gttctgggac ttctggctgg
     7201 ggggatcgcc aagctgatcc tgcccggacg ggatccgggc ggctgcatcg gaacgacggt
     7261 gatcggcatc gcgggcgcgt tcctgggcgg ctggctgtcg gcccggttcc tcgaccgccc
     7321 cgtgcagaag gagttcttcg acgcggcgac ctggggttcc gccatcgtcg gcgcgctcgt
     7381 cctgctgatc ggctaccgcc tgctgttcgg caactcccgc gactgacggg cactcccccg
     7441 gccccctcct ccgcaccctt cgctccctcc tacagcaccc ggcgcaggcc cggcagtcgg
     7501 cgcagtcctg ccgcgaggag gaaggcggac ggcagtgcga ggacgacggc ggcgcaccac
     7561 gagccggccg cggacagacc gcggccggcc agggcgtact gcacggcgac gaccagcggc
     7621 acatggatga tgtagacgcc gtaggaactc gccgccagtt ccctcgacca ccgggcaccg
     7681 ccgcgcacga actcccggaa gagcgtgagc agtccgacgc acagggacac gcacagcgca
     7741 ctctcgcaga ccgcccacac cgcggacggg acgtccgccc cgcccggccc gaaccaccgt
     7801 gagtcggccc cggccaggaa cagcagcgcc acgcccgccg ctcccacggc cagccacacc
     7861 agccccaccc gggtgtcgaa gcgctccagc cagtcctgac ggccggcgac gacgcccagc
     7921 gcgaagaagg cggcgtactg cggcaccctc gcgggctcga cctgcaggaa gtccaggacg
     7981 ggcacccagg cgtcgagggg gtaccgcagg cggacgagga acgtcgcacc ggccagcagg
     8041 acggtcagcg ccaccagggc gcggtgcccg ggcggcgcga cagcacgccc ggggccgcgc
     8101 cggacccgca gcgggcggcc gagccggcgg aggaccacgt acaccacggt gcaggcgagc
     8161 aggttctgca cgaaccacag gtgtccgaac tggaggtccg gccaggacgg cccgctccag
     8221 cccgccggtt cctcccccat gccgaggtac acgtcggtga agtagcgcgt gaacggcatc
     8281 ggcgggtagc cgcggtagtg ggtgaagtag gcgtacatca gtcccggcac gatcgtcagg
     8341 gcgccgacga cgacggggat gccgagccgc acgaaccggc cgcgcaggaa gcgccgggtg
     8401 ccgtggcgct cgcacgaccc gggtatgagg acggcggaga cgaagaagaa caggctcatg
     8461 aagaaggagc cgtcgacggc ggagagcgtg gcgagggccc cggcacgcgg ctggccctcg
     8521 acgtaccacc agtcggcggg gccgtagggc tgggcggcgt ggtggaccac gaccaggacg
     8581 gtcagggcga tgcgcaggtt gtccagccat gcgaggcgac ggagtcgcgg tgtcgaggtg
     8641 tacatgtgtt gagtttcctc aacacatgta cacccggcac tggggctatc ccccggaccg
     8701 gtcctccggg cagccgtaga agccctggac cagcaggcgc tgattggccg cgctgcggcg
     8761 tgcgaggacc tccggagcga acatcggttc ctcgaggttc ggttgcatca cccgctccag
     8821 cagcagcgga ccgaggatga ggcagagcat ctggaacggc gcccaggtgc tgtcggcctc
     8881 ctcgcctccc cgggcaccgc cgtacacgga ggacagccgc tccagctcgg tccgcgctcc
     8941 ccgcagcagc ttgccgaaca gcgcggcgcc ggcctcgccg tcctccagga ggacctgccg
     9001 caggtagccc cgcagtacgg ggtccgcccc gaacagacgg gcggagaccg ccccgagcga
     9061 ctccatgagg tccgcgtccg gatccacgtc ggccagttcc ccgccgatgc gctccagcac
     9121 gtcctggtcg accgccgcgc gcagcccgtc cttcgacccg aagtggcggg tcaccagagc
     9181 aggggacacg cccgccgccg tggccaccgc ccgcgtcgag gtcgcctcga acccccgctc
     9241 ggcgaacagt tccagagccg ccttccgcag ccgcgcccgc cccgtcagat cacccttctc
     9301 cacacgcatc cccgcagcgt agccaagcgc gcggggacac gcgccgccgg tcagccgccg
     9361 gcgaggacgt gccggtcgag ccagtcgccg acggtgcggg gcagggcgtc gccgtcggca
     9421 ctgcgggcgt ccacgttgtc ggcgtgcagt tcgagcaccg gaatgccggc ggcctcgagc
     9481 gcgcgtggtg aagtagctgc cccgggcgtg ggcctggccc gttcgcgggc agacggacac
     9541 tcccgcggag acgcgctcgg cgacctcgtc gtggaaggcg cgggcggtgt cgcgcgccca
     9601 ggtggtaccg cggtgccact gggggatcat cacgctgggg acgctgtcgt tgaccggcag
     9661 cgggcacgga cgggcacggg cgatgaggtc gcgggtacgg cgattccact cctgccgctc
     9721 gtcgacgagg tgcatcacct cggcgaagcc ggtctcggag atgacgcgtc cggtggtctg
     9781 cgccaggaac ctgagccctt cgagtcaccc gtcatgagga ccgggcggtc gctgccgacg
     9841 gcgccttccc agtcgcgcgg catccaccac ggtcacggcc cggcggacgg agctcgccgc
     9901 ggccccgggc acgcatccgc cggccgcggc cgacccggac ggcgaggcaa cgctgggcgt
     9961 ctttcccggg gcggcgggcg gcagcggtcg gaaggccgct tcatcgcccg gccgtcccgg
    10021 aggtgaccgc ttgggggaag gtgaagaggt ggtccgggtc gcaggcggcc ttgacgcgtt
    10081 gcatcctcgg gtagttctcg ccgtggtagg ccgtctgcca gtcggtgagt tccgggtcca
    10141 tgccgttggt gtagccgccg gttccgaggt gggtctgcag ggtggtgtgg gtgtcgcgca
    10201 gccactcgat tctggcgtcg acgtgcgcgg ggtcggtgaa ctggtgccag taggagtggt
    10261 attgcacgac gccgacggcg gcccggtggg ggaaggcggt cgcccccggc ggccggtcgc
    10321 cgaccgcgcc gccgagggcg tcgatgagca ggccgccggc cccgcccacc gcggtgaagc
    10381 ggtgcagccg ttcgagggcc gccgccatgt cggacgccgc cgcgggactg agcggctccc
    10441 gcacgatgtg cgacttggcc gcgaaggcga cccggggccc cagggtgcct cctccccagc
    10501 ggtcggcctc actggcggcc cgggtgtagt cgcaggggac gaggacccgc tcggcctccg
    10561 gcaggcccac cgcggcggcc agccggtcca gcaccggttc gagtgcgccg ggcgggccga
    10621 tgaacgtccc ggtcaccgtg ggccgcgagg gcagaccgga gtcgctgagc tgttcgaagg
    10681 cgcaggtcac cgtccggggc gtcgacgggt cggcgttcca gaccgaccag ccccgcagca
    10741 cggccgcggt ggcggcggag ggccagccgg ccaggaacct cgtgcagctc aggtcgcgga
    10801 tgtcctcggt ggcgaactcc agcgcggtga cggcgccgaa gttgcctccg ccgcccccgc
    10861 acagggccca gaacaggtcg ccgtccgggt acggcgagtc cgcccgcacc cggcggacgc
    10921 ggccgtcggc ggtgacgatc tccacctcgc gcaagtggtc gcaggccaga ccccaggcgc
    10981 gggtgaacgc ggacagacct ccgccgaggg tgactccggc cagaccgatg gtggggcacc
    11041 ggcccagcgg caggccggca ccggccgcgg ccagcgccag gtgggcctgc tggcccttga
    11101 cgccggcacc gaacctggcg tacccgccgc ccacggcggt ggagttgagg gagctgacgt
    11161 ccaccacgag cccggggccg gtggagtatc cggcgtagct gtgcccgccg gagcgcagcg
    11221 ccagcgggac gcggctcgtg cgggcgaagt cgacgcactc gaccacgtcg tggacgtccg
    11281 ccgggtaggc gatcgcctgg ggacggatgc cgtcgaaccg ctggttgacc agcaggcggg
    11341 cctgttcgta ggcggcctgc tccggccgca acagcacccc gcgcaggccc gcctccagcg
    11401 ccggccactt cgccgcggag cccgcggagc ccgcggagcc cgcggagccc ttgaccggca
    11461 ccggtgacgg cgtgcggggc gccgtggcgg ccggcacgcg gacgctgcgc agggcggaca
    11521 aggtgtggat gtcggcgagc accggatagt cgaacggcaa cggccgcggg ccgacctggt
    11581 cgggcggcgc ggtgaagccg ccgtcggagt cctgccgctc cagcaggtac gtcagcgccc
    11641 ggcccacggc gagcggctcg ccgtgacgtg ccagtacggg gacggcctgg gcggtggaca
    11701 ggacgtcgcc ggggtcgccg ggaacctggc cccagccgcc gtcgggacgc tgcgtcgcga
    11761 cgaggcgccg cgccgcgcgg gcggtggcgg ccgcgatccg cgcggccagg ccggcgtcgg
    11821 cagcggggat cgcgtggagc gcgtcgacgg cgcgcaggac ggcgctggac tcgctgaccg
    11881 tccagctgcg ttcgaaggtc ccgtccgggc gctgggcttc gaggacgcgt tcgatcgcgc
    11941 cggacaggag gcgctcgtgc cgcgcggccc ggggggccag cgcgaggacg gcgccggcgg
    12001 tcatgtcgag gtccggtgtg tcaccgcgca cccacgtggg gaagccaccg tccgggccgg
    12061 cgatcccggt caggtacccg gccgccctgt ccagcacctc ccggtaccgg tcaggtccgg
    12121 cggcgtgcag gaactccatg caccgggtgg tggtgtccac atcggtctgc cgcatgccgg
    12181 tggcgaaggg ccagcccccg tcgggcgcct gccaggaggc cacgaggtcg gccatccgcg
    12241 gcacctggcg cgccagactg tcctcggcgg tgaacgccag gccggccacg gcggtcagcc
    12301 acaggtcctg gctgtccagg aacggcacgc cgtcgtcggt gttgacggcc aggcacagcc
    12361 gcagcaggcc gtcgtcgagg accgggtcgc cgggccggaa ggtgcgcacc gcgtgcaggc
    12421 cgagcaggtg ggtggtggca ctggcctccc acagcacccg gttgcgtccg cgtgccagca
    12481 gcgacaccag acggttgcgt tccgcgtcgg tgacctcgtg cgggcggtgg cgggcgtgcg
    12541 cgtggacgat gcgggccgac agcaggtgga cgtcggtgaa ggtggtgagg ccggccggtg
    12601 cgaccggggc gggcgcgtcg ccgctctcca gtgccgagcc gcacagcagg tgcagcaccg
    12661 tgcgcagcat gacggacttc agccgcccgc gcccggcggt gccgctgctc atcgccaagg
    12721 gcagggcggc ggcccgctcc ggcgcccggc cggcggtgcc ggcagggtcg aggcaggcgt
    12781 cgatcagcag ggcgtccacg tcgttcgcgc cggggcggcg ccgccgcagg aagcgagcga
    12841 gacggtcctg ctcgtccggt tcggcgccct gtgcccgcag cagggccagc agcagcgtgg
    12901 actccagcac ccggctgccg caccggtcgt ccacatgacc ggccgcgtcc acggcgacga
    12961 ccaggtgctg agcgagggcg gacacgcccc gttcgtggtc ggcggcaagg aatccgcctc
    13021 ccgcggcgtt gcggtgggtc tcccgctgcc aggcgagcga gccgtcccgc acccggcgga
    13081 tcggcgcggc ccggtcgccc cgtgcggccc ggtcgaactc gtccatgcgc tcggcgagca
    13141 tggcgcgggc gtgggccgcg gcccgggccg ggctgcaccg gtggtggcgc gcgagtacgc
    13201 cgacgaggtt ctccgcgccc tcgtccgcct cccgccgcgc ggaccgcagg tcgttggccc
    13261 aggcgacgat gtcggcggcc gcgtcccgca gcccgtcgag ttccaccgcc gggggccggg
    13321 cccgctccac cacggccagc atcggcagga cggtgatggt acggcggcgc agtgccacgt
    13381 agtcgtccag tccgagccgt tcaccgctcg agcgcagccg tagttcggtg acggtggcct
    13441 cggcgaagtc ccggtacagc gtgcggaagc gctgcctcca gcccggccgg gccgcgatcc
    13501 gggtccgcgc ccacaggtcg gcgagggcgc gcaccaccgg cgccgccgac ggcgggcagc
    13561 gggtcccgtc gtcgcccccg agcacggcga ggagctcgtc cagtacggcc ccggcctgct
    13621 ccggcgactg gccgtgccgg tcgaaaccgt cgtcgaccga cgcgatgaac gcaccccact
    13681 gcgcgagcag cgccagctcc gccggaccgg cgccgggcgc cagccacccg gccatccgtc
    13741 cgtgccccgt ccgggccagc cgccgtgcct cctccccgtc ggcgacgagg tggtgcgcga
    13801 cggcccaggc acgcgctcgg cgttcggcgt gcgcccagtc gggggcgcac acggtgcccc
    13861 tctcccccgt tccacggagc ggcgcccctt ctcgcatgtc accctccgtc ccgtcgcggc
    13921 gcggcccgtg ccgctcgacc cagcacaccc cgtcctcgtc cgccggggtc cggccgcggc
    13981 ggcaaaccac ccgtccgtgc gaatcaggtg gccccaccgc gccggagcgg gcaggcggac
    14041 ggtcagtcga cgaagaagtt ccagaacgcg ccgacttccg tctccgagac cgccaggatg
    14101 ccgaagtccg tgatgaggcc gtcgcgttgc gcgtccaccc ccgcgaagca ggagagggag
    14161 aagccgtcgc ggtaccagtg ggggtccgtg ccgccgctga ggtcctcggc gttggtggcg
    14221 tactccgcct cggggccgaa acgggccagg agggtgcggg ccgccgacca cagccggctc
    14281 cgtcgcaccg ggtcggcggc gccgggcggt tcggcgccgc cgtggggtgt ggcggtccag
    14341 tgcagcgcgg tcagttccac cgcggcctca tgggtcagca gttcgagatg atggtcgagg
    14401 tggtgcggct ccagccggtc gaaggggtag tacgggctgt gtccggtgcg ctcgggccac
    14461 ctgctgtggg cgtcgggcag ccagccgcgc ggatcgcgcg tgcggaaccg gagcacggcc
    14521 gcggcgtcca cgagccagtc ctcgtgccgc cggggcccca cggcggccaa ctggcagccc
    14581 aagacgatga gcgcctgccg ccattcctgc cgcccggggg cggggtgcgt cccgggacgg
    14641 tacggaagca tgcgggcacc ctaacagcgg gcgcgcgccc cggttcggca gcacgtgccg
    14701 gccggcgggc tcaggtcagg ccggtcgccg cgagggccag ggcggtgcgc aaggtggtgg
    14761 cgaggtcggc gtgggcgggc gcggcttccg agcccggtgc ggccgaccgg tgggcgtggt
    14821 gctccacggc cgcgcgcagt gcggcgttga gcatggcggc ccagacggcc ggtcgtacgt
    14881 cgtcgtcggg cagtccggcg cgctcggcga gggcgcgtgc gaaggcgggt tccgcttcgt
    14941 cgcgggtctg cagccagacg gcgcgcaggc ccggttccgt gcgggtcagc cggagcaggg
    15001 ctccgacgtc cggtccggcc aggtcctggt cgtcggccca cacaccgtcg aaggcctctt
    15061 ggaggggccg gccggggcgc cactcgcgca gcgcggcggc gatcgtgtcg atgccggacg
    15121 agaacagcgg ccgtacgcag ctctccttgg tggggaagta gcgccacacc gtcctcgccg
    15181 agacgccgac cgcctgaccg atctgctccc ccgtggtcgc ggcgacgccc tgcgcgacga
    15241 acaggccgac cgcggcccgg gcgatctcca gccggatggc ggccttgcgt tcgtcggtca
    15301 gcggcggacg ccccgtccgt ccacgggctg cggtcatctg gccctccggc gccggtgatc
    15361 gatgtcctgc gtattctgcc ccaggagtta atgtcactcc gcgacataaa gtcgtagggt
    15421 gtcggcacgg cacggcggcg ctccgccgcg ccggcccttt cgtgaacgga gcagtcgatg
    15481 accatgggtg tggacgggcg aagcgtgatc gtcaccgggg cgggatcggg cataggccgc
    15541 gcggcggccc tcgccttcgc cgctcagggc gaccgcgtcc tggtggcgga cctcgacgcc
    15601 gaaggcgccg cggcgaccgt cgaggagatc gagcggtcgg gcggcaccgc ggtggccgtc
    15661 acgggcgacc tgagcgagca ggccgtcgtg gaccgggtga ccgccacggc cgtggagcgg
    15721 ttcggcgggg tggacgtcct ggtgaacaac gcgggaatca tggacagcat gtcggccgcg
    15781 gccgatgtcg ccgacgccga atgggaccgg gtcatccgcg tcaacctgac ggcgccgttc
    15841 ctcctcaccc gcgccgtgct gccgcacatg ctggccgccg gccgcggcgc catcgttaac
    15901 accgcctccg aggccgccct gcgcggcagc gcggcgggcg ccgcgtacac ggcctccaag
    15961 cacggggtgg tgggcctgac gaagtcgctg gcggtgatgt accgcaagaa cggcgtccgt
    16021 gccaacgccg tctgcccggg cggcaccgcg acggccatcg cggtggaggc cgacccggcg
    16081 gcgcacgggc cggccgcgct cggtccccac ttcgtcaatc tcggccgtgt gtcgcagccg
    16141 gacgagcagg cggcggcgat cctgttcctc gcctcggagg ccgcgggcaa catcaacggt
    16201 gcgatcctgc cggtcgacga cggctggtcc gccgtctgac acggtcccac cgcccacgcc
    16261 tcccacgccg ccgcgggacg tgcggcccgg gcgcggacct acccccgcgc agggtgcctg
    16321 gggctcagga tctcgtccat ggactccttg cgccaccgcg cgaggagctc gtggaaggcg
    16381 acggcgccgt gcgggtaggc ggtggggccg ttcggcctgc cgcgcccctc ggcgttgtag
    16441 tagcccgggg tgcattccgc gtggaaccac tcgtggtcgg gcgcgtgctc ggccagggcg
    16501 gcgatccagg cgtcctcggc ttctcgggac ggttcgacga gggcgtcctt tgcctcggcg
    16561 gccgcgacga gtgccgcgcc gtggaccgcg tgctcgtcca gtacgtgcgt gtagttgacg
    16621 ctgctggcgc tctgcgtccc gccgagctgg atcaggttcg ggaagccgtt gctggtgaat
    16681 ccgtgcagcg tgcgcggacc gtgtgcggac cacgcgtcgc gcagcaggac gccgccgcgg
    16741 ccccgcacgg gcagccggcc ggagtggacg ccggagacgc cgaccgagaa cccggtggcg
    16801 aagacgaggc agtcgagggg gtattcggtg ccgccgacca cgacaccgcg ctcggtcatc
    16861 cgctcgatgc cgtgggtgtc ggcggtgtcc acgagggtga cgttgtcccg gttgaacgcc
    16921 tggaggtaca ggtcggagaa ggtcgggcgc ttgcacgcgt accggtacca gggcttgagc
    16981 cggtccgccg tctccgggtc ggtgaccacg tcgtcgaccc gggcgcggat ctcgttcatc
    17041 ttgacggcgt ccgcgacctc gtacgccgct tcgaaggcgg cccggtcgcc ggtccggcgg
    17101 aagctcggca gcagcttctc caggagaccg gccgaggcgg tccaccggtc ggcgacgagg
    17161 tcctccccgg tggcttcgcc cgagacgatg cgcaggaagt tctcgcgccg ctcacgcgcc
    17221 cagccgggcc ggtcggcgcc cacgtcccgg gccgtggtgc ggcggttgtc gcgcacgtcc
    17281 acggaggacg gggtccgctg gaagacgtag aggtgcccgg cgtcctcggc cagtttcggg
    17341 acgacctgca ccccggtggc gccggtgccc accacgccca cgcgcttgtc cgcgaggccg
    17401 gtcaggccgc cgtccggggt gccgccggtg taggcgtagt cccagcgcga ggtgtggaag
    17461 gtgtggcccc ggaaggcctc gatgccgggg atgccgggca gcttcagctc cgacagggtc
    17521 ccggtggccg tgatgacgta ggtcgcccgg aactcgtcgt gccggtcggt cccgacgatc
    17581 cacgccccgt ccgtgtcgtc ccaggtcagc gaggtgaccg cggtggagaa cagggcgtcg
    17641 gcgcagaggt cgaacttctc gccgatgcgc accgcgtgcc ggcggatctc ctcgccgggg
    17701 gcgtacttcc actccgggac gtagccggtc tcgtcgagca tcggcaggta cacgtgcgcc
    17761 tcgatgtcgc agtggatgcc ggggtagcgg ttccagtacc acgtgccccc gaagtcacct
    17821 cccttctcga tgacgcgcac gcgcgcgatc ccctgctgac gcagtcgcgc gcccgcgagg
    17881 atgcctccga agccgccccc gacgatcgcg acgtcgacgc ggtcccgcac cggctcgcgg
    17941 ccggccgcct ccgccgcgta cgggtcggcg gcgtagtagc cgaactcggc gtccgcgccg
    18001 aggtactggc gggtgccgtc gggacgtacg cggcgctccc gctcgcgccg gtaccgctcc
    18061 ctgagttcgg cgagaacctc gggagtcagc tcctgtgcct gtgccatgtg gggggacctt
    18121 gttccttccg cttcgccgcc aggaagccgc tcccccgcga accgggttgt gccgaacggg
    18181 acttgagcag ccatgcagta cggtaacaag aaccggacaa cgctgtccgg ttggcctcag
    18241 gctgcttccg catactttcg gacaggaaga gtgatgcaca tgcgacgcgt tccgatccgg
    18301 cccctcgccg ggctcgtcac gctcggggta ctggcccttg cggggtgcgg tacgcagacg
    18361 gccggcgcac cgcgggaccc ggggaccgcc gagggcgacc ggacgatccg cgcacagcag
    18421 gtcatgcgcg tgacggaggt gcacgagcag accgggatga ccctgctgga gggcccggtc
    18481 ttcgacgggg acggcaggct gctcgtcgtc gacgtcaccg ccccggccgg cgagccgaag
    18541 gtcctgcgcg tgaatgtccg gaagaagacg tcggagcccg tccacacgga tgcgcgcggc
    18601 gcctacacct cggcccagtt cagcccgtac gacggccgga tctacctgac cgacttcgcg
    18661 cacggggaca tcgtgagcct ggctcccgac ggcggcgacc cgcggacctt cttctccggc
    18721 gaggtcgacg gggcacggat gaacccggac gacctcgcct tcgacccgga gggccatctg
    18781 tacgtcagtg actcgcgcgg catgtccgag ggcgaggcga agggacgcgt ggtgcggatc
    18841 gagcgctcgg gcaaggacgc caccgtcctg gcggacggcc tcgccgcgcc gaacggcatc
    18901 tccttcgacg cggactaccg ggggctgtgg ttcagcgagt tgacgcagaa ccgcgtctcc
    18961 tacctgctgc tggacggcaa gggcgccgtg gcttcgcggc acaccgccgt ccgggtcgac
    19021 gccgggatcg cccggaccga ctccgtcgcg gtggacgcgg acggcaacct gtaccagggc
    19081 ctgcacggcc gtcccgcgat ggcggtctac gacaagtacg gcgagcgcct ggcgaccgtg
    19141 gaggtcccgg cccgcgacgc cgcgggactc gagtcggcga ccaacgtggc gatcactccg
    19201 ggcggcacca gggcctacat gacggtgagc ggccccgacg ggggctacct gtacgccttc
    19261 gaggcactgg gcaggggcac ccggcagtcc aacggcggct gacccgcggg cacttgctca
    19321 ccccgcgaag ggaagcacgg gtcccacctc gacgccgaga agccgccacg ccgcccgccc
    19381 ccggcgctcc cgctcctcgc gggtggggcc ggtgacggcg ccggagacca tggcgacggc
    19441 gatcatgagg tcgtcgtccc ccgcggccag ccggtgaccg tccggcaggt gtgcgcgcag
    19501 ggcacgcccg acccgctccg acagggcccg cgcgtacggg ggaacgacgg agcggctgcc
    19561 cgccccgtcg gcgtgcagga tgccgatgaa ggccgccgac tccgtcaggt gccaggtcag
    19621 gacccccagc acgcgcgcca ggtccgtgcc cggcacggcc gcggcctgct cgacctgccg
    19681 gacgttctcc tccagcaccg cgtcggccac ggcctcccgg tcgggaaagt gccggtacag
    19741 aacgccctgg ccgaccccgg cccgacgggc gatcgccgac agcggggcgt ccaggccgtg
    19801 ctccgagtag atctccctcg cggcggcgac cagggccgct cggttacgag cggcggcctt
    19861 cggcccctcg ttcgcgggcc gctgctcccc ggacatgcgg tgctgcgtca cccccgagag
    19921 cctacccggg cggctgcgcg gtcggcaggg gagcctctcc cccgggatgc ccgcgtctcc
    19981 ccctccccgt cgggcagtcg agatccccac cgcttgccgc agcggcctcg gccgctcctc
    20041 agtcgaaggt ctcgacgtac tcctgcggcg gtccgaggtc gggacggtct cgcagggcca
    20101 cgcggtcgcc gaagcgttcg agttccagca cggtcagcgt gttgtctccg gggcgcagga
    20161 gcgggccggg caggtagagc gtggtctgcg ggccgatctc ccagtagcgg cccagcagcg
    20221 tgccgttgac ccagaggaag cccttgccga atccgggcag ggcgacccag gcgtcggcgg
    20281 gctcggccac gggcaggacc gcggtggcga agcccgcccg gccgtccgcc ggggccgccg
    20341 ccgcggcacg ggcggcgtcc cgcggtgtcc accggtcgag cggcagcgcg cgcatcgtcc
    20401 atccgtgcac cagccggcgt tccacccgta cgccgccgag gatgcccttg ccctggccca
    20461 gcagcggtcc gtagttgatc cgcccctggt tctccaccag cagcgccagc cggacgcggg
    20521 ctccggtgcc ggggacgtcg aaggaggcgt tctcgcggtc cagtacggcg acgggttcgc
    20581 cgtcgaggaa gacctgcgca cggtcgtgca ggccggagac ggtcagctcg tgggtgcccg
    20641 gcggcagcag cggttcggcc tcgtagagca ccaggccgga ggccagggag agttcctcga
    20701 agctcagcgg cagcggcgcg gacaccggct cggccgccgc gcgcagcgcg tccagcaggg
    20761 ccgcgcgccg ggtcaccggc agctcgcggg gtgccagcac cggcgggtcg gcgggcaggg
    20821 ggcgcggggg ccccgaggcg tcgagcgcgg tcagcttctc ccgcagggcg aagaacttgg
    20881 gcgtcagcgc cccgttctcc gcgatggggg cgtccgagtc gtagctggtg acggtcggcc
    20941 ggatgcggtc gccgtcgtgg ttggcgccgg cccacaggcc gaagttggtg ccgccgtgcg
    21001 ccatgtagag gctcaccgag ccgccctcgt cgaggatgtc accgacggtc tccgccgcgc
    21061 cgtccgccgg ccggacgtgg tgcttctcgc cccagtggtc gaaccagccg ttccagaact
    21121 ccgcgcagaa gaagggttcc ccggggcggc gggagcgcag cagttccgcg gcccgggcgg
    21181 ggcgtgagcc gagggtcgcc gccgccagtt caccgggcag ggcgccgccg tcctgcatga
    21241 gcgcggtcgg tccgtcggcg gtgtagagca gttcggtgac accccgggcg acgagggcgt
    21301 cgcgcacgtg gcggacgtag gcgtggtcgt cgccgtagct gccgtactcg ttctcgatct
    21361 gcacggcgac gaccggtccg ccccggcccg cctggaggtc cgcgatccgc gggatcagtt
    21421 cgtcgaacca gcggtccacc gcggccagga aggggccgtg ggaggtgcgc agccgcatgc
    21481 cgggcgtccc ggtcagccag gcgggcaggc cgccgttgtc ccattcggcg cagatgtagg
    21541 ggcccggccg caccacgacg tccagcccct cctcctgggc gagccggacg aacccggtca
    21601 ggtcgcgcgg gccgtcgaag cggatgtcgc cctcggtgcg ctcgtggaag ttccacggga
    21661 cgtaggtgtc gaccgtgttc aggccgaggg cggccagccg ccggagccgg tcggcccagt
    21721 gcccggggtg gacccggaag tagtgcagcg agcccgccag aaggcggtgc gggcgcccgt
    21781 tccgcagcag ggtgccgtcg gcgtgggtca ggacggccgc cggagagagg gtggtcatgc
    21841 gacggccccg gcggccggcc ccgcgtgccc gcgaccggga gtggactccc ggaatgttat
    21901 cgatgccttc atgtcactcc tagatcagta gccagaacta tggcaggaaa tgttatcgat
    21961 gccaacggcg gctcgacagg gagtcgacca ccgggagcga cggcggaccg gggacgccgc
    22021 ggtccgtgcg agcaccgcgc gccgcgcacg gcgacgtacg gcttcggggt cgtccctgac
    22081 ccgttcgagt gcaaagggac cgcgccggac cgcgtgtcat ttgccaccag cggtatgccg
    22141 cgccccgcgc gacgagaatg ccccgcgtac ctgacgcaga gcatctggag gccttggcgc
    22201 cgtgaccacc gtcgaagggg cccacagccc cgcagcaggc gaccattacg cggacgaact
    22261 gcccctcctg cgcaaggcgc ccggcaatgc agtgatcaag tggctgacga ccacggacca
    22321 caagacgatc ggcacgctgt acctggtgac gtcgttcgcc ttcttcctga tcggcggcgt
    22381 tctggcgctc atcatgcgcg ccgagctggc ccggccggga ctgcagatcg tctccaacga
    22441 gcagttcaac caggcgttca cgatgcatgg cacgatcatg ctgctgatgt tcgcgacgcc
    22501 gctgttctcc gggttcacga actggatcat gccgctgcag atcggcgcgc cggacgtggc
    22561 cttcccccgg ctgaacatgc tcgcctactg gctgtacctg ttcggctcgc tcatcgcggt
    22621 gggagggttc ctgacccccg gcggtgccgc cgacttcggc tggttcgcct actccccgct
    22681 gtccaacgcg gagcactcgc ccgggatcgg ccccgacctg tggatcatgg gtctggctct
    22741 ctccggcttc ggcaccattc tcggctcggt caacttcatc accacggtcg tgtgcatgcg
    22801 cgcgccgggc atgaccatgt tccgcatgcc gatcttcacc tggaacgtgc tgctgaccag
    22861 tgtgctcgtc ctgttcgcct tcccggtgct ggccgcggcc ctgctcgccc tggaggccga
    22921 ccgcaagttc ggtgcccaca tcttcgacgc gcccaacggc ggggccctgt tgtggcagca
    22981 cctgttctgg ttcttcgggc atccggaggt ctacatcatc gcgctgccgt tcttcggcat
    23041 catcaccgag atcatcccgg tcttctcccg caagccgatc ttcggctaca tgggcctggt
    23101 gggagcgacc atcgcgatcg ccggtctgtc ggtgacggtg tgggcccacc acatgttcgt
    23161 gaccggaggt gtgctgctgc cgttcttctc gttcatgtcc ttcctgatcg cggtcccgac
    23221 cggtgtgaag ttcttcaact gggccgggac gatgctcaaa gggtcactca gtttcgagac
    23281 accgatgctg tgggccaccg gcttcctggt caccttcctg ttcggcgggc tgaccggagt
    23341 gctgctggcc tcgccgccgc tggacttcca cgtctcggac tcgtacttcg tggtggcgca
    23401 cttccactac gtggtgttcg gcacggtggt gttcgccatg ttcgccggct tccacttctg
    23461 gtggcccaag ttcaccggca agatgctcga cgaacgcctc ggcaagatca ccttctggac
    23521 gctgttcctc ggcttccacg gcacgttcct ggtccagcac tggctgggcg ccgagggcat
    23581 gccccgccgt tacgtcgact acctcgcgtc cgacgggttc accgccctca actcggtctc
    23641 gagcatctcc tccttcctgc tgggcctgtc catgctcccg ttcctctaca acgtgtggaa
    23701 gacggccaag tacggcaagc cggtcggcgt ggacgacccg tggggctacg gccgttcgct
    23761 ggagtgggcg acctcctgcc cgcccccgcg ccacaacttc tgcaccatgc cgcgcatccg
    23821 cagtgaatcc cccgccttcg acctgcacca ct
//
