LOCUS       NZ_BBOK01000010        24831 bp    DNA     linear   CON 17-AUG-2024
DEFINITION  Streptomyces sp. NBRC 110030, whole genome shotgun sequence.
ACCESSION   NZ_BBOK01000010
VERSION     NZ_BBOK01000010.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. NBRC 110030
  ORGANISM  Streptomyces sp. NBRC 110030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Katano-Makiyama,Y., Hosoyama,A., Hashimoto,M., Tsuchikane,K.,
            Uohara,A., Kitahashi,Y., Ohji,S., Ichikawa,N., Kimura,A.,
            Yamazoe,A., Komaki,H., Igarashi,Y. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Streptomyces sp. NBRC 110030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 317359)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 97x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417675.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,152
            Genes (coding)                    :: 7,019
            CDSs (with protein)               :: 7,019
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 45 of 133
            Pseudo Genes (incomplete)         :: 107 of 133
            Pseudo Genes (internal stop)      :: 8 of 133
            Pseudo Genes (multiple problems)  :: 23 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:33:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 24831
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBOK01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24831
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="oligosaccharide"
                     /region_number="1"
                     /rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /tool="antismash"
     cand_cluster    1..24831
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /kind="single"
                     /product="oligosaccharide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24831
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="True"
                     /core_location="[583:14831]"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      584..14831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
     gene            complement(<1..558)
                     /locus_tag="APK71_RS22800"
     CDS             complement(<1..558)
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (3-31). E-value:
                     1.4e-13. Score: 42.2. Matches aSDomain:
                     nrpspksdomains_APK71_RS22800_PKS_Docking_Nterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153112.1"
                     /locus_tag="APK71_RS22800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_055468931.1"
                     /sec_met_domain="mod_KS (E-value: 5.2e-66, bitscore: 217.4,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 5.7e-49, bitscore:
                     161.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNEEKLLQYLKRATADLREARRRLRENEQRAGEAIAIVGMACRY
                     PGGVSSPEGLWRVVRDGVDAIGEFPEDRYWDVEGLFDPVPGVPGKSYAREGGFVRGAAD
                     FDAEFFGISPNEALEMDPQQRLLLESSWEALERAGIVPGSLRGSATGVFAGVMYHDYAG
                     SAALGSVVSGRVAYALGLEGPAV"
     CDS_motif       complement(172..198)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS22800_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KS_m2"
                     /locus_tag="APK71_RS22800"
                     /protein_end="129"
                     /protein_start="120"
                     /score="11.0"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(466..549)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS22800_PKS_Docking_Nterm.
                     1"
                     /evalue="1.40E-13"
                     /label="APK71_RS22800_PKS_Docking_Nterm.1"
                     /locus_tag="APK71_RS22800"
                     /protein_end="31"
                     /protein_start="3"
                     /score="42.2"
                     /tool="antismash"
                     /translation="EEKLLQYLKRATADLREARRRLRENEQR"
     gene            complement(584..1942)
                     /locus_tag="APK71_RS22805"
     CDS             complement(584..1942)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04516.1"
                     /locus_tag="APK71_RS22805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_370592495.1"
                     /sec_met_domain="MGT (E-value: 7.6e-123, bitscore: 404.7,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLWRRDNVAITVPSPCPVGRGFMRVLLTTHAVHSHLYNLVPIAW
                     ALRTAGHEVCVATHPNFLETAKSTGITTVPVGEELAAPRDLPAAPGAPAGSGTPFGFGY
                     DMAETRPEVLTPAYVRGTLATYTSRMCEYLSNQSMLDDLVEFARAWKPDLVVWDAHHYA
                     GPVLARAVGAAHARILAAPDHWARMHSLLPAPAPGQSAAPGDDPLADYLGGKLAPYGAE
                     FDQEMVVGQATIDPLPSFLRVPLPNGHLPMRHVPFNGPATIPAWLRRKPRRPRVCLTLG
                     MTRRASGVEQRAGNAFPFATVLEQLAGLDVEVVATLSADQVPPGTSIPENVRIFDYLPL
                     NALLPTCAAIVHYGGMGTVGVAAVHGVPQLSIPGNIWGEGVVMRQWAEQGAGLVADADT
                     LVERLGRLIDDPSFAAGAERIQKEMLTAPSPHDLVPALEELTERHRGSRTDAA"
     gene            complement(1983..2975)
                     /locus_tag="APK71_RS22810"
     CDS             complement(1983..2975)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (12-226). E-value:
                     1.3e-20. Score: 65.5. Matches aSDomain:
                     nrpspksdomains_APK71_RS22810_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715037.1"
                     /locus_tag="APK71_RS22810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_030402456.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.2e-13, bitscore:
                     43.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.6e-08,
                     bitscore: 27.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 6.7e-20, bitscore:
                     65.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSGKWSGKTAVVTGGTGFIGSHFVEELLAAGADVTCLYRRDNRG
                     VLPQLPRTERLRPVQCDALDEHALGAVFDALPQVDAVFHCAVVSGTWDFRREHSAQILD
                     TNMRTVSNTLRLARRHSVPEVVILSSSDVYLSPTTDPIREDDDFHRQMHYHPDGYYLSK
                     TYTEVLAETYRNEYGMNIYLPRLTSVYGPRDNFEVDTTRVVPSMFAKAVSGQDIEIWGD
                     GSQTRTYMYVTDLVRAILQTVGNDKYHTINVGTAETVSVLQLAQYVCAALGQPERITFL
                     RDKSGGRPSRNLDLGRLDELIDFRPRTLREGLEATVDWYRRHRPYQPLT"
     aSDomain        complement(2298..2939)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS22810_NAD_binding_4.1"
                     /evalue="1.30E-20"
                     /label="APK71_RS22810_NAD_binding_4.1"
                     /locus_tag="APK71_RS22810"
                     /protein_end="226"
                     /protein_start="12"
                     /score="65.5"
                     /tool="antismash"
                     /translation="VTGGTGFIGSHFVEELLAAGADVTCLYRRDNRGVLPQLPRTERLR
                     PVQCDALDEHALGAVFDALPQVDAVFHCAVVSGTWDFRREHSAQILDTNMRTVSNTLRL
                     ARRHSVPEVVILSSSDVYLSPTTDPIREDDDFHRQMHYHPDGYYLSKTYTEVLAETYRN
                     EYGMNIYLPRLTSVYGPRDNFEVDTTRVVPSMFAKAVSGQDIEIWGDGSQT"
     CDS_motif       complement(2877..2942)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS22810_0001"
                     /evalue="3.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="APK71_RS22810"
                     /protein_end="33"
                     /protein_start="11"
                     /score="13.5"
                     /tool="antismash"
                     /translation="VVTGGTGFIGSHFVEELLAAGA"
     gene            complement(3013..4332)
                     /locus_tag="APK71_RS22815"
     CDS             complement(3013..4332)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891742.1"
                     /locus_tag="APK71_RS22815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_030402457.1"
                     /sec_met_domain="MGT (E-value: 2e-142, bitscore: 469.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFAVYGAKTHFYNVVPMAWALRAAGHEVCVASQPEIVDAITR
                     TGLPAVAVGEEVDLRLRSGAGGDDHVTSGSSWRDLNAGVTETRPEELTWDYVLGTFTIA
                     CSMHYEHATGGRPMLDDLVEFARHWRPDLVIWDAMTFAGPVAARACGAAHARMLFGIDY
                     IGRMYGDYATQLAAQPPERRDDPVGDWQAGRLARFGCPWDDTLATEMMTGQWTIDPTPP
                     WMQFPLDLPFTPVRYLPFNGPTAVPDWVHEPPKRPRVCLTLGMTAREVLGGDLFSTAQM
                     LQALAELDIELVATLDAGQLAELDTLPDNVRVTDFVPLNDLLPSCSAIVHHGGFGTLGN
                     ALAHGVPQIIAPGRYWDEVRFGERLADRGAGLLLDYERLSGDGLRNQLDAHMLKNQINR
                     LLGEPSFQENAALIREELLATPSPHDLVAELEELTAHHRD"
     gene            complement(4402..5622)
                     /locus_tag="APK71_RS22820"
     CDS             complement(4402..5622)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="APK71_RS22820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_030402458.1"
                     /transl_table=11
                     /translation="MAKALIIGGGVAGPASAIALQRAGLEPVVYEAYERDADGIGQNLV
                     LAVNGYSALLTLGVGHLARGFDIPRYRFHLGNGKELCQVRNGSPLPDGTAARAITRSDL
                     YTTLRDAAIDRGIETHFGKRLVDASLTEKGVVARFADGTEATGDVLVGADGLHSVTRKV
                     IDPSGIRYRYGGLWTTGGYATGVDVPSDPGTEFMYLGKRGFFCHIPDPEGRVWWYASIT
                     RPEEPDPKDLAAITPEEWRAELIRLFSGDDNSAVDLINATEAIWPPRPIQDIPSLPKWR
                     NDRMVVIGDACHAVSPSAGQGVSMAIEDAVVLGKCLRDIPDIPRALAVYEDIRRERVER
                     IVAFGKQCGQALMTGSKARRIGRDVFARIAFSQRGAEKGQEEMRWLYDHRIDWDAPIGT
                     TNVPAGA"
     gene            5853..7169
                     /locus_tag="APK71_RS22825"
     CDS             5853..7169
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04515.1"
                     /locus_tag="APK71_RS22825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="P450-derived glycosyltransferase activator"
                     /protein_id="WP_055468933.1"
                     /sec_met_domain="p450 (E-value: 3.7e-14, bitscore: 46.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRHQVDPRLLDDSELTRHLLAARGTQWMRGNRGDPYALILRAQG
                     IDPHALYRGMRGRPALRQSESDTWVTASYTAGAEVLEDERLTLRDPKARRRRKVFGIDA
                     GSSLKHVLQLDDDVLARPPAFYTELSAAVAPVLGSAALERHRGAVDGVFERTLGSLGGS
                     FDLMEDFARPGTVAAVAELLGLSEAERAEVAVLCPGAGTALDALLCPPTLGMTRRLVES
                     FDGLRKVVDTLVAARSAAPGDDPVSRLLREAPDPGGAAADATVALMLTLVVGVETTANL
                     VCDAVLALLADPGQLALVREDPGLVAGAVEETLRFQPPVRLESRIVSEEVQIAGQRLDK
                     GHQVVVLVDAAGRDPEVYPEPERFLVDRAPGVPPLSLHGRSPAGFTAPVVRFVAGAALG
                     RLVADRVGTLGLAGDVVRRMRSPVVQGVARCPVAATQAG"
     gene            complement(7177..8052)
                     /gene="rfbA"
                     /locus_tag="APK71_RS22830"
     CDS             complement(7177..8052)
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0045226 - extracellular polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="rfbA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008748194.1"
                     /locus_tag="APK71_RS22830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="WP_030402460.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-13, bitscore:
                     46.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIILAGGTGSRLNPVTIAVTKHLLPVGEKPMIYYPISVLMFGG
                     IKEVLIIARPEDITQFQRLLGDGSHLGLSIEYAEQPRPTGLADAFVIGADHIGDDSVAL
                     VLGDNIFHGPGFQNLLDEHTKDVQGCVLFGYGVKDPERYGVGETDALGRLVSIEEKPLR
                     PRSNRAITGLYLYDNDVIDIAKNVRPSPRGELEITDVNRVYLERDRATMVDLGRGFAWL
                     DTGTPESLLQASLYVRTLEERQGVRIACLEEIALRKGFIDADQCHRLGEALGNSGYGQY
                     VMDIARELSA"
     gene            8214..9323
                     /locus_tag="APK71_RS22835"
     CDS             8214..9323
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963467.1"
                     /locus_tag="APK71_RS22835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_030402461.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.6e-121,
                     bitscore: 398.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLVWDYLAEYEEERDDILDAVDHVFRSGRLVLGNSVRSFEEEF
                     AAYHGVAHGVGVDNGTNAVKLGLQALGVGPGDEVITVSNTAAPTVVAIEGTGAKPVFVD
                     VRAEDYLMDTAQVEAAVTDRTRCLLPVHLYGQCVDMEPLREIAGRHGLAVLEDCAQAHG
                     ATHHGRSAGSMSDAAAFSFYPTKVLGAYGDGGAVITSGAETADALRQLRYYGMAERYYV
                     VRSPGHNSRLDEVQAEILRRKLRRLDQYVQGRRAVAERYAEGLGDTELVLPRTTPGNEH
                     VYYVYVVRHPRRDAVIEALKSYDIMLNISYPWPVHTMSGYAHLGYAEGSLPVTESLAGE
                     IFSLPMYPSLSPDVQDKVIDALREVLRTV"
     gene            9359..10801
                     /locus_tag="APK71_RS22840"
     CDS             9359..10801
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346889.1"
                     /locus_tag="APK71_RS22840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NDP-hexose 2,3-dehydratase family protein"
                     /protein_id="WP_053638043.1"
                     /transl_table=11
                     /translation="MTEHPAAPAAVPGRIGRSVDARDSRVAPLDTFHPWFKECAERAYT
                     DVRPIPLDELAGWTTDPVTGNLAHVSGGFFRVEGLDVTVPDGPVPHWTQPIINQPEIGI
                     LGILAKEFEGVLHFLMQAKVEPGNVNGLQLSPTVQATRSNYSRVHRGRPVPYLDYFREP
                     GRHRVITDVRQSEQGSWFYRKRNRNMIVEVTEDVELLDGFRWLTLGQIHQLLALDDIVN
                     MDARTVLSCLPFSGPTHRPAPGPEDDSFTAALLRSCHGVGGALHPDDHILNWVTEVRTR
                     SEVLTRPLPLNALEQWRRGEYAITHDSGQFFELIAVDVRAGGREVGGWTQPMIKPRDGG
                     VVAFLVKSIGGVLHVLMHALVEPGYLDVAELSPTVQCTPRNFDHLPDAARPMFLDEALG
                     APADRIRFDAVLSEEGGRFYHARNRYLVVETDIDAGFSHPDFRWMTVRQLVDLLRHSHY
                     VNIQARSLVACLHSLTGQPPVV"
     gene            10842..12038
                     /locus_tag="APK71_RS22845"
     CDS             10842..12038
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487468.1"
                     /locus_tag="APK71_RS22845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_053664024.1"
                     /transl_table=11
                     /translation="MSQCRICSSTVREFLDFGSHPLSSAFVSPDATGEEFRYRLAVGAC
                     TSCGMVQLTEDVPRERLYHKGYPYHSAGSTVMHAHFEETGRGFLARELGGPDPFFVEIG
                     CNDGVTLRTVADAGVRHLAFEPTGVAGGRVHSAFFDAESAAEVRAAEGPAQVVYSANTL
                     CDIPGIGAVFEGADILLAPDGVFVFEDPYLGEILARTSFDQIYDEHVFFFTARSVASMA
                     ACFGFQLVDVERLPVHGGQIRYTLARAGRRTPTAAVAELLAEEAARGIGEAAGLDRFGA
                     AVHTVRRDLVALLRDLTAQGHRIAGYGATAKSSTVTNFCGIGPDLVPYVCDTTPSKQGK
                     LTPGMHIPVRPDTAFRDPYPDYALLFAWNHAEEIMAKEQAFRDAGGRWILYVPEVHIV"
     gene            12095..13381
                     /locus_tag="APK71_RS22850"
     CDS             12095..13381
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128142.1"
                     /locus_tag="APK71_RS22850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_030402464.1"
                     /sec_met_domain="MGT (E-value: 3.7e-135, bitscore: 445.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFTVFAVKTHMYNLVPLAWALRAAGHEVCVASHPDLAEAITR
                     TGLTAVPVGDPLSMGGAGKGPTTQTFQGVSGSMVEDPSDDPSWERVLGTFTVACSVQYE
                     YLAGLQVMDDLVEFAQAWQPDLVVWDALTFTGAVAARACGAAHARMLFGMDYVARMYGR
                     YTELLAAQPPERREDPVTEWTAGRLARYGVKSGPEDTLEMLTGQWTIDPTPSWMQFRLP
                     LPYLPVRLVPFNGPTTAPDWVREPAARPRVCLSLGMSGRDQLGGDLLSIGDLLDALADF
                     DIELVATLDSRQLAGTSALPDNVRPVDFVPLNDLLPTCAAAIHHGGFGTVGSVLTHGVP
                     SITIPAPWWDETDLGRRIAARGAGFLMDPHRPDLDALRDHLRRLLDDPSFTARAADVRA
                     DLLATPSPHDLVPELERRARSYRTRQGDR"
     gene            13434..14831
                     /locus_tag="APK71_RS22855"
     CDS             13434..14831
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008748189.1"
                     /locus_tag="APK71_RS22855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_063788283.1"
                     /sec_met_domain="MGT (E-value: 5.5e-134, bitscore: 441.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLTVFAAKPHLYNLISLAWALRASGHEVRVASQPDVTDAITR
                     AGLTAVPVGDELNLSASFRPGEDRAGAEQGGVWQRLSGVTETRPEKLTWNYVLGTYTIG
                     CSMEYEHMAGQTMMDDLVEHARAWRPDLVLWDALTFVGPVAARACGAAHARVLFGVDYN
                     AHMLGAYADLLSAQPPQTRDDPLSDWLTGRLARYGLPFEPEDAVEMMTGQWTIDPTPAW
                     MQLPVGVPLLPMRYVPYNGPSTVPGWVLERPRRPRVCMSLGMSGRELLGRDQMSIGDGA
                     SAEPPVSVLLRTLAELDIELVVTLSKDQLAAVSGLPDNVRAVDFVPLNDLLPTCAAVIH
                     HGGFGTVGNVLTHGVPSITVPAPWWDETDLGRHIEARGAGLLVDPREASAEVLRAGVAR
                     LLGEPSFRSAAHAVRRELHATPSPRAVVPQVERLVAVHRSGSQLPCSPSGTLRGRWMRA
                     IGSAVKS"
     gene            complement(14741..16105)
                     /locus_tag="APK71_RS22860"
     CDS             complement(14741..16105)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379812.1"
                     /locus_tag="APK71_RS22860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_055468934.1"
                     /transl_table=11
                     /translation="MSRFLAGPFAPVDEEVTAFDLPVTGRVPGELAGRYLRIGPNALGV
                     EDPAAHHWMSGPGMVHGVRIRDGRAEWYRNRWVRSEQVRGLLGEPSGGAACEIGIDFAC
                     NTHVIGHGGRTLALMEDWACPQELTAELDTVGPYALGGVRPGFTMGAHTKLDPLTGELH
                     GLAYLSGRRTARHLVVDGTGRLVHEAEIPLDGNPMMHDFALTERWVVVYDSPVVFSPEA
                     MSTGARTPYTRDPRRPSRVGVLPRAGGGVRWFEAPDAFVSHTLNAYDDGERVVLELVAL
                     PADFDIAAMRMSRYGTLDRWTVDLSAGTVCEQRLDDRPQEFPRIADTVVSRPHRYGYTA
                     ATAAMYQAYVPAGDGPLPDEAFVNALIKHDTVRGTSEVHTFERDAAAGEAVFVPAAGGR
                     AEDDGYVMGYVHDPRRGAADLVILAAQDFTAEPIARIHLPRRVPLGLHGSWLPDR"
     gene            complement(16177..16992)
                     /locus_tag="APK71_RS22865"
     CDS             complement(16177..16992)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="APK71_RS22865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_030402467.1"
                     /transl_table=11
                     /translation="MTTATTYEEAVRPCGGGSRIAWAFSDARVLAGRYVRHILRQPEEI
                     ATAVLIPTVLMLMFRYMLGGAVDAGGSSYANFLVPGILAIGVTLISVSTTVGVFLDMQE
                     GFVDRLRSMSTLATSVVIGHIVAAVMRALIGLVVLTAIGFAVGFRPSAGVLQYLAAFAL
                     LMLFAVAVGWISALFGQLARSTEGASGLALTLTFLPYASNVFAPTETMSPGLRVFVEHQ
                     PVTAVIDAVRALLLDQPVGNAAWIAVLWWGGIIALAVPLSNRLFRRRFS"
     gene            complement(16989..18014)
                     /locus_tag="APK71_RS22870"
     CDS             complement(16989..18014)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847171.1"
                     /locus_tag="APK71_RS22870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_063788284.1"
                     /transl_table=11
                     /translation="MANSYAIEISGLTKSYGDVHVLKGVDLQVERGTMLALLGPNGAGK
                     TTLVRILSTLIGPTGGTAVVHGHDVVHQAAGVRRSIGLVSQFMALDYVHSGRENLVMLG
                     RLQHLRAPAARRRAEELLEQFDLVEAADRPVKTYSGGMRRRLDLAISLITAPPVLFLDE
                     PTVGLDPRSRRTLWGVIRELLAKGSTILLTTQYLEEADQLADRVAVIDEGRIAAQGTAT
                     ELKQRIGAERMQVTFDTDEDFLKADALSRAGDEHLQWDRETRTVSVATDDLELLVRTLD
                     ELRRSGARIGSLDVARPSLDDVFLTLTQHTSATGQPGTRSVNPPAASAAAGAETVGSRS
                     E"
     misc_feature    18013..18028
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.87"
                     /tool="antismash"
     misc_feature    complement(18054..18072)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.71"
                     /tool="antismash"
     gene            18122..18931
                     /locus_tag="APK71_RS22875"
     CDS             18122..18931
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345862.1"
                     /locus_tag="APK71_RS22875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_051783494.1"
                     /transl_table=11
                     /translation="MAAEHDGADRLSRSLDLLWGSKDKPSRGPKPALSLEKIVRAAIEI
                     ADAEGIDGLSMQQVAGRLGFTTMSLYRYVPGKDQLVDAMMDAASGPPPQLPAAEGWRNR
                     IERWVQALWVRYQQHPWMLQVQASGPPLGPNQLAWLESSLSALDGTGLTAEEMLFVSLF
                     LNGAATGLARHSTAAAQTAAHTGVPAERVGADYAQILERVLDTDRFPTLTRVVAAGAFR
                     PGAGPGEGTTHDLEFGLQRLLDGIERYVEERTATCPLGTSASATGPV"
     misc_feature    18956..18967
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.86"
                     /tool="antismash"
     gene            19233..20084
                     /locus_tag="APK71_RS22880"
     CDS             19233..20084
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445156.1"
                     /locus_tag="APK71_RS22880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_031087369.1"
                     /transl_table=11
                     /translation="MPYGEGSFHATGTGTGRHRAPEQAFQETLVPPEPGWDPAEELAFL
                     LQDAMEQQTGAPFAPDPSALAPAPGTPLSNLQEITAELPPLRESPTSHRRVRRGRKVSR
                     LRAASLFVAALAAVIAASVSLFGGMVAYEPLRLAAVTRTRGSVVSWWPLLVYGPWLVAS
                     LAVLRAALHQRRAVHSWAVVLLFSAIAMFLCVAEAPRTVSDGAAAALPGLASLVCFQQV
                     VRQITLTRPPRRAVPRHRQRAAVTPGDDPSGRAASDAVSLPQQRQNHPRSSRPGPRPGK
                     RI"
     gene            complement(20207..20650)
                     /locus_tag="APK71_RS22885"
     CDS             complement(20207..20650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445157.1"
                     /locus_tag="APK71_RS22885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6299 family protein"
                     /protein_id="WP_030402471.1"
                     /transl_table=11
                     /translation="MRVRSAALATAAGAALLLLTAPAAPAAPHDARLAAESVTVDPVGR
                     IAADGSVTLTGTYRCTGGTGPVFVSSSVSQSDPSVRYGVGGTRAVCDGLEHRWANTGTP
                     DQVVLKPGAAQVEATLMELRPMGIVPLPSFHARQTQDVTLTAS"
     gene            20915..21124
                     /locus_tag="APK71_RS22890"
     CDS             20915..21124
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973034.1"
                     /locus_tag="APK71_RS22890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /protein_id="WP_030402472.1"
                     /transl_table=11
                     /translation="MCTRRPSCPAAASPEARAEGAHVVAAHPEQGWNLLCDGTIVFDDT
                     GELRPDGQAVAPRRLPGGPLAVAA"
     gene            complement(21150..21977)
                     /locus_tag="APK71_RS22895"
     CDS             complement(21150..21977)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-117). E-value:
                     3.3e-09. Score: 28.7. Matches aSDomain:
                     nrpspksdomains_APK71_RS22895_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146352.1"
                     /locus_tag="APK71_RS22895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_053638040.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-06, bitscore: 22.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDIELSAGTIEYEDTGGDGPVVVLLHGLVHDATVWRGVVADLRT
                     DHRVIAPTLPYGAHRRPMRRPPTPDLVNELIAEFLDRLDLTGVTLVENDCGRAQTVAAR
                     HPERLARLALVACEAFDNYPPGLPGKLIGLACRTPGGVSALVRVLGLAPLRRLPVGIGA
                     LTKRPVPDEVVDGWLRPLRTDPAVRRDFRHYNTHVRRDELLEAAQGLRRFDRPALVVWA
                     TEDLMMPRAHGRRLAELLPRGRLVEVEDSRTLIPEDQPELLASLLREFVAGRP"
     aSDomain        complement(21627..21917)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS22895_Abhydrolase_1.1"
                     /evalue="3.30E-09"
                     /label="APK71_RS22895_Abhydrolase_1.1"
                     /locus_tag="APK71_RS22895"
                     /protein_end="117"
                     /protein_start="20"
                     /score="28.7"
                     /tool="antismash"
                     /translation="PVVVLLHGLVHDATVWRGVVADLRTDHRVIAPTLPYGAHRRPMRR
                     PPTPDLVNELIAEFLDRLDLTGVTLVENDCGRAQTVAARHPERLARLALVAC"
     gene            complement(22005..22403)
                     /locus_tag="APK71_RS22900"
     CDS             complement(22005..22403)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523541.1"
                     /locus_tag="APK71_RS22900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RidA family protein"
                     /protein_id="WP_053638039.1"
                     /transl_table=11
                     /translation="MTAERINPPELSPPTGFSHAVVATGTRVVLLAGQTALDTDGAITG
                     DTLPAQFERALTNLLTALRAAGGTPADLARVTVYATDVAAYRTHAADLGRTWRELAGRD
                     YPAMAVVEVVRLWDERALVELDGFAVLP"
     gene            complement(22400..23605)
                     /locus_tag="APK71_RS22905"
     CDS             complement(22400..23605)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445230.1"
                     /locus_tag="APK71_RS22905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_055468935.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.5e-12, bitscore:
                     41.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.3e-21, bitscore:
                     69.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-48, bitscore:
                     159.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAFSLEPAHVTWCEELRALAVQRLRPLAEKGEPGRVNRALVAEL
                     GALGLLSRLFTSGALDLCLMRESLARACTEAETALALQGLGAHPVHTHGTEAQRARWLP
                     RVSDGTAVAAFALSEPGAGSDAAALSLRAEPDPRPGGGPSAWRLTGEKCWISNAPEADF
                     YTVFARTTPGAGARGVTAFLVPADRPGLTGSALDMLSPHPVGALSFDAVPVTADDVLGA
                     PDEGFRVAMGTLNLFRPSVGAFAVGMAQAALDATLAHTTARDAFGGTLRDLQAVSHQVA
                     EMALRTEAARLMVYAAATAYDAGAPDVPKRAAMAKLLATETAQYVVDRAVQLHGARALR
                     RGHLLEHLYREVRAPRIYEGASEVQRGIVAKELYRTYHPDATTTETTETTETTETTEET
                     GA"
     misc_feature    complement(24346..24357)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    complement(24382..24395)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.79"
                     /tool="antismash"
ORIGIN
        1 caccgccggc ccctccaacc ccaacgcata cgccacccgc cccgacacca cactccccaa
       61 cgccgcactc cccgcataat cgtgatacat caccccagca aaaacacccg tcgcactccc
      121 ccgcaacgaa cccggaacaa tccccgcccg ctccaacgcc tcccacgacg actccaacaa
      181 caaccgctgc tgcggatcca tctccaacgc ctcattcgga ctgatcccga aaaactccgc
      241 atcaaaatca gccgcaccac gaacaaaccc accctcacgc gcataactct tccccggcac
      301 ccccggcacc ggatcaaaca acccctccac atcccaataa cgatcctccg gaaactcccc
      361 aatcgcatcc acaccatccc gaaccacccg ccacaaaccc tcgggcgaag aaaccccacc
      421 cggataccgg cacgccatcc ccacgatggc gatggcctct cccgcgcgct gctcgttctc
      481 ccgcagccgt cggcgggcct cccgcaggtc ggcggtcgcg cgcttgaggt actggaggag
      541 cttctcctcg ttgtccaccg gttctccagg cagttcgtgt cgttcaggcg gcgtcggtcc
      601 gggagccccg gtgccgttcg gtgagctctt ccagggcggg gacgaggtcg tgcgggctcg
      661 gggcggtcag catctccttc tggatgcgct ccgctcccgc cgcgaacgac gggtcgtcga
      721 tgagccggcc cagccgctcg acgagggtgt cggcgtcggc gaccaggccg gcgccctgct
      781 cggcccactg ccgcatcacg accccctcgc cccagatgtt gccgggaatg ctcagctggg
      841 gaacgccgtg cacggcggcg acgccgaccg tgcccatgcc gccgtagtgg acgatcgccg
      901 cgcacgtcgg caggagggcg ttaaggggca gatagtcgaa gatccgcacg ttctccggga
      961 tgctggtgcc cggcggcacc tggtcggcgc tgagggtggc cacgacctcg acgtccaggc
     1021 ccgcgagctg ttccagcacc gtggcgaagg ggaacgcgtt gccggcccgc tgctcgacgc
     1081 cggacgccct gcgggtcatg ccgagcgtca gacagacgcg cggacgcctc ggcttgcgac
     1141 gcagccaggc gggaatggtg gcgggaccgt tgaacgggac gtgccgcatc ggcaggtgcc
     1201 cgttcggcag gggaacgcgc aggaaggacg gcagcgggtc gatggtggcc tgcccgacca
     1261 ccatctcctg gtcgaactcg gccccgtagg gcgcgagttt gcccccgagg tagtcggcca
     1321 gcgggtcgtc gcccggtgcg gcggactgcc cgggcgcggg ggccggcagc agggagtgca
     1381 tcctggccca gtggtcgggg gcggcgagga tgcgggcgtg tgccgcgccg acggcccgcg
     1441 cgaggaccgg cccggcgtag tggtgcgcgt cccagacgac caggtccggc ttccaggccc
     1501 gggcgaactc caccaggtcg tcgagcatgg actggttgga caggtactcg cacatcctgg
     1561 acgtgtaggt ggcgagtgtt ccccgtacgt atgcgggagt gagcacctcg gggcgggtct
     1621 ccgccatgtc gtagccgaat ccgaaaggcg ttcccgatcc ggccggggcg ccgggggcgg
     1681 ccggaaggtc gcggggggcg gcgagttcct cgccgacggg caccgtggtg attccggtgc
     1741 tcttcgcggt ctccaggaaa ttggggtggg tggccacgca cacctcgtgc cccgcggtgc
     1801 gaagcgccca ggcgatcggc accagattgt agagatgtga atgcacggca tgagtggtga
     1861 gaaggacgcg cataaatcct cttccaacgg gacaaggcga ggggacggtg atggccacgt
     1921 tatcccgccg ccacaacggc atcacaccct tatttacgtg gcggagttcc gctgccgggc
     1981 cttcacgtta ggggctggta ggggcggtgc ctgcggtacc agtcgacggt cgcctcgagc
     2041 ccttcgcgga gggtgcgcgg gcggaagtcg atgagttcgt cgagccttcc gagatcgaga
     2101 ttgcggctcg gccggccacc cgatttgtca cggaggaatg tgatgcgctc gggctgtccc
     2161 agtgcggcgc acacgtactg tgcgagctgg aggacggaga cggtttccgc ggttccgacg
     2221 ttgatggtgt ggtacttgtc gttgccgacg gtctgcagga tggcgcggac cagatcggtg
     2281 acgtacatgt aggtcctggt ctggctgccg tctccccaga tctcgatgtc ctgtcccgag
     2341 acggccttgg cgaacatgct ggggacgacg cgggtggtgt cgacctcgaa gttgtcccgg
     2401 ggaccgtaga cgctggtgag cctgggcagg tagatgttca tgccgtactc gttgcggtag
     2461 gtctccgcga gcacttccgt gtacgtcttg gacaggtagt agccgtccgg gtggtagtgc
     2521 atctgccggt ggaagtcgtc gtcctcgcgg atggggtccg tggtcggcga caggtacacg
     2581 tcgctggagc tgaggatgac gacttcgggg acgctgtgcc gtcgtgccag ccgcagcgtg
     2641 ttggagaccg tgcgcatgtt ggtgtccagg atctgcgccg agtgctcgcg gcggaagtcc
     2701 caggtaccgg agaccaccgc gcagtggaag acggcgtcca cctgcgggag tgcgtcgaag
     2761 acggcgccga gcgcgtgctc gtcgagcgcg tcgcactgca ccgggcggag ccgttcggtg
     2821 cgggggagct gaggcaggac accccggttg tcacggcggt agaggcaggt cacgtcggcg
     2881 ccggcagcga gcagttcttc gacgaagtgc gatccgatga acccggtgcc accggtgacg
     2941 acggctgtct tcccggacca ctttcctgat gacacgctgt ttactccctc gcaggcgctg
     3001 gggaccgagg ccctagtcgc ggtgatgggc ggtcagttct tccagctccg ccacgaggtc
     3061 gtgcgggctg ggggtggcga gtagctcctc acggatgagg gcggcgttct cctggaacga
     3121 cggctcgccg aggagccggt tgatctggtt cttgagcatg tgggcgtcga gctggttacg
     3181 caggccgtcg ccggaaaggc gttcgtagtc gaggaggagg cccgcgccgc ggtccgccag
     3241 ccgttcgccg aagcggacct cgtcccagta gcggccgggc gcgatgatct gggggacgcc
     3301 gtgggcgagg gcgttgccga gggtgccgaa gccgccgtgg tgcacgatgg cggagcagct
     3361 gggcagcagg tcgttcaggg gcacgaagtc cgtgacgcgc acgttgtcgg ggagggtgtc
     3421 gagttcggcg agctggccgg cgtcgagggt ggccacgagt tcgatgtcga gttccgccag
     3481 cgcctggagc atctgcgccg tggagaacag gtcgccgccg aggacttcgc gtgccgtcat
     3541 gccgagggtc aggcagaccc gggggcgttt gggtggctcg tgcacccagt cgggcacggc
     3601 ggtgggcccg ttgaacggca ggtaccggac cggggtgaac ggcaggtcca gggggaactg
     3661 catccatggc ggcgtggggt cgatggtcca ctggccggtc atcatctcgg tggccagtgt
     3721 gtcgtcccag gggcagccga agcgggcgag gcggccggcc tgccagtcgc cgaccggatc
     3781 gtcccggcgt tccggaggct gcgcggcgag ctgcgtggcg tagtcgccgt acatcctgcc
     3841 gatgtagtcg atcccgaaca gcatgcgggc gtgggcggcg ccgcaggcac gggccgccac
     3901 cggaccggcg aacgtcatgg cgtcccagat gacgaggtcg gggcgccagt gacgggcgaa
     3961 ctcgacgagg tcgtcgagca tcggccggcc gccggtggcg tgctcgtagt gcatggagca
     4021 ggcgatggtg aaggtgccga ggacgtagtc ccaggtcagt tcctcgggcc gggtctcggt
     4081 gacgcccgcg ttgaggtcgc gccacgagga gccgctggtg acgtggtcgt cgccgccggc
     4141 gccggagcgc aggcggaggt cgacctcctc gccgacggcg acggcgggca ggcccgtgcg
     4201 cgtgatggcg tccacgatct cgggctggct cgcgacgcac acctcgtgcc cggcggcgcg
     4261 cagcgcccag gccatcggga ccacgttgta gaagtgtgtc ttcgcgccgt acaccgcgaa
     4321 caggacgcgc atggcggctc ctccccctgt cgtgccacgg ccgctggtcc ggtcacagcg
     4381 gccggccgat gcctccggct cctacgcccc ggcgggcacg ttggtggtgc cgatcggcgc
     4441 gtcccagtcg atgcggtggt cgtagagcca gcgcatctcc tcctgcccct tctcggcgcc
     4501 gcgctggctg aacgcgatgc gggcgaacac gtcccggccg atcctgcggg ccttgctgcc
     4561 ggtcatcagg gcctggccgc actgcttgcc gaaggcgacg atgcgttcga cgcgttcgcg
     4621 gcggatgtcc tcgtagacgg ccagggcccg ggggatgtcg gggatgtcgc gcaggcactt
     4681 gccgaggacg acggcgtcct cgatggccat ggagacgccc tgcccggcgg acggcgagac
     4741 ggcgtggcag gcgtcgccga tgacgaccat ccggtcgttg cgccacttgg gcagggaggg
     4801 gatgtcctgg atgggacggg gcggccagat ggcctcggtg gcgttgatga ggtcgacggc
     4861 ggagttgtcg tcgccggaga acaggcggat gagttcggcg cgccactcct cgggggtgat
     4921 ggcggccagg tccttcgggt cgggctcctc ggggcgggtg atcgacgcgt accaccacac
     4981 gcggccctcg gggtcgggga tgtggcagaa gaagccgcgc ttgccgaggt acatgaactc
     5041 ggtcccgggg tcgctgggga cgtcgacgcc ggtggcgtag ccgcccgtgg tccacaggcc
     5101 gccgtagcgg taacggatcc cggaggggtc gatgaccttg cgggtgacgg agtgcaggcc
     5161 gtcggcgccc acgaggacgt cgccggtggc ctcggtgccg tcggcgaagc gcgcgacgac
     5221 ccccttctcg gtgagcgagg cgtcgacgag ccgcttgccg aagtgggttt cgatgccgcg
     5281 gtcgatggcc gcgtcgcgca gcgtcgtgta caggtcggag cgggtgatgg cacgggcggc
     5341 ggtgccgtcg ggcagcgggg agccgttgcg cacctggcac agctccttgc cgttgccgag
     5401 gtggaagcgg tagcggggga tgtcgaagcc gcgggcgagg tggccgacgc cgagagtgag
     5461 cagagcgctg tatccgttga cggcgaggac gaggttctgc ccgatgccgt cggcgtccct
     5521 ctcgtacgcc tcgtagacga ccggttcgag cccggcccgc tgcagggcga tggcgctggc
     5581 gggtcccgcg acgccaccac cgatgatcaa agctttagcc atcaggcctt cccgtcatcc
     5641 ggtcacgtga atgggggtac gcactcccac caggtacggg cacaccctca cacgccgccc
     5701 gggccccttc agcccctatc cacccctttt cgccgcaggt gggccggtga cctgcagtac
     5761 cgggcggcag gggtggccca ctggtgccgg gaacggctag gaacgacaca gaccgtgtcc
     5821 accggggtgt gacggaaggg agctccacag ccatgacgag gcatcaggtc gatccgaggc
     5881 tgctggacga cagcgaactg acgcggcatc tgctggcggc tcgcggtacg cagtggatgc
     5941 ggggcaaccg cggtgatccg tacgccttga tcctgcgcgc gcagggcatc gatccgcacg
     6001 ccctgtaccg ggggatgcgg gggcggccgg cgctgcggca gagcgagtcc gacacgtggg
     6061 tgacggcgtc gtacacggcg ggtgccgagg tgctggagga cgaacggctg acgctgcgcg
     6121 atccgaaggc gcggcgccgc cggaaggtct tcggcatcga cgcgggttcc agcctgaagc
     6181 acgtgctgca gctcgacgac gacgtgctgg ccaggccccc ggcgttctac accgagctgt
     6241 cggcggcggt cgcgcccgtg ctcgggagtg cggcgctgga gcggcaccgc ggcgccgtcg
     6301 acggggtgtt cgagcggacg ctggggtcgc tggggggttc gttcgatctg atggaggact
     6361 tcgcgcggcc cggtacggtc gccgcggtcg cggagctgct ggggctctcc gaggccgagc
     6421 gcgcggaggt ggccgtgctg tgcccggggg ccggcacggc gctcgacgcc ctgctgtgcc
     6481 cgccgaccct ggggatgacc aggaggctcg tggagtcctt cgacgggttg cggaaggtgg
     6541 tcgacacgct ggtggcggcg cggtccgcgg cgcccggtga cgacccggtg agccggctgc
     6601 tgcgcgaggc cccggatccg ggcggggcgg cggccgacgc gaccgtggcg ctgatgctca
     6661 ccctggtggt gggcgtggag accacggcga atctggtctg cgacgcggtg ctggcgctgc
     6721 tggccgaccc cggtcagctg gcgctggtac gggaggaccc cgggctggtg gcgggtgccg
     6781 tcgaggagac gctgcggttc cagccgccgg tccgtctgga gagccgcatc gtgagcgagg
     6841 aggtgcagat cgcgggccag aggctcgaca aggggcacca ggtggtggtc ctcgtcgacg
     6901 cggcgggccg tgatccggag gtgtacccgg agccggagcg gttccttgtc gaccgggcgc
     6961 ccggcgtgcc cccgctgtcg ctgcacgggc gctccccggc gggcttcacg gcgcccgtgg
     7021 tgcggttcgt ggccggggcg gcgctcggga ggctcgtcgc cgaccgggtc ggcaccctgg
     7081 gcctggccgg tgacgtggtg cgccggatgc ggtcgcccgt cgtgcagggc gtcgcccgct
     7141 gcccggtggc ggccacgcag gcgggctgac gccctgtcag gccgacagtt cccgggcgat
     7201 gtccatgacg tactggccgt agccggagtt gccgagggcc tcgccgaggc ggtggcactg
     7261 gtcggcgtcg atgaagccct tgcgcagggc gatctcttcg aggcaggcga tgcgcactcc
     7321 ttgcctctcc tccagggtcc gcacgtacag ggacgcctgg agcagcgact cgggcgtgcc
     7381 ggtgtccagc caggcgaacc cgcggccgag gtcgaccatg gtggcccggt cgcgctccag
     7441 gtagacccgg ttgacgtcgg tgatctccag ctcaccgcgc ggggaggggc ggacgttctt
     7501 cgcgatgtcg atcacgtcgt tgtcgtagag gtacaggccg gtgatggcgc ggttcgaccg
     7561 gggccggagg ggtttctcct cgatggagac cagccggccg agggcgtccg tctcgccgac
     7621 cccgtagcgc tcggggtcct tgacgccgta cccgaagagg acgcagccct ggacgtcctt
     7681 ggtgtgctcg tcgaggaggt tctggaagcc gggtccgtgg aagatgttgt cgccgaggac
     7741 gagggcgacc gagtcgtcgc cgatgtgatc ggcgccgatg acgaaggcgt ccgccaggcc
     7801 ggtcggccgc ggctgctccg cgtattcgat ggacaggccc agatgcgatc cgtcgccgag
     7861 caggcgctgg aactgggtga tgtcctccgg cctcgcgatg atcagtactt ctttgatgcc
     7921 accgaacatg agcaccgaga tggggtaata aatcatcggc ttttcgccga ccggcaggag
     7981 atgttttgtc acggcgatgg ttaccggatt gagccggcta cccgtaccgc cggcaaggat
     8041 tattcccttc atgggcgcaa gctagcgata tcatcgcatt ccccgcaaga cgaataccgt
     8101 tggtctgggg tggccccaac cggtgtgggg cggctagggg ttgtgagttc ctggcgggct
     8161 ggccagactt gggccggttc gcaccgcccc attatgcaga atcgggagta tctgtgacca
     8221 cgctcgtctg ggattatctg gcggaatacg aggaagagcg cgacgatatc ctcgacgcag
     8281 tggaccatgt cttccggtcc ggcaggctcg tgctcggaaa cagcgtgcgg agcttcgagg
     8341 aggagttcgc ggcgtatcac ggcgtcgccc acggcgtcgg cgtcgacaac ggcaccaacg
     8401 cggtcaagct cggcctccag gccctgggcg tcggccccgg cgacgaggtc atcaccgtct
     8461 cgaacaccgc ggcaccgacg gtcgtggcca tcgagggcac cggcgcgaag ccggtcttcg
     8521 tcgacgtgcg cgccgaggac tacctcatgg acaccgccca ggtcgaggcg gccgtcaccg
     8581 accggacccg gtgcctgctg ccggtgcacc tgtacgggca gtgcgtggac atggaaccgc
     8641 tgcgggagat cgccggccgg cacggtctgg ccgttctgga ggactgcgcc caggcccacg
     8701 gggccaccca ccacggccgg tccgccggca gcatgagcga cgcggcggcg ttctccttct
     8761 acccgaccaa ggtgctcggc gcctacggcg acggcggcgc cgtcatcacc tccggcgccg
     8821 agaccgccga cgccctgcgc cagcttcgct actacggcat ggcggagcgc tactacgtcg
     8881 tccgctcccc cggtcacaac agccgcctgg acgaggtgca ggcggagatc ctccgccgca
     8941 agctgcgccg gctcgaccag tacgtgcagg ggcgccgtgc ggtcgccgag cggtacgccg
     9001 agggcctcgg cgacacggag ctggtcctgc cccgcacgac gcccggcaac gagcacgtgt
     9061 actacgtgta cgtggtccgc cacccgcgcc gcgacgccgt catcgaagcc ctgaagtcgt
     9121 acgacatcat gctcaacatc agctacccgt ggccggtcca caccatgagc ggctacgcgc
     9181 acctcggtta tgccgaaggg tcgctgcccg tcaccgagtc cctggccggc gagatcttct
     9241 ccctgccgat gtacccgtcc ctgtcgccgg acgtacagga caaggtgatc gacgcgctgc
     9301 gcgaggtcct gcgcaccgtc tgaccgcagg ccgcccgaca gcagacgagg agccctcgat
     9361 gacggaacac cccgccgctc cggcggcggt gccggggcgg atcggccggt ccgtcgacgc
     9421 ccgcgacagc cgggtcgcac cgctggacac cttccacccg tggttcaagg agtgcgccga
     9481 gcgcgcctac acggacgtgc ggcccattcc cctggacgag ctggccggct ggaccacgga
     9541 cccggtcacc gggaacctcg cccatgtcag cggcggcttc ttccgggtcg aggggctcga
     9601 cgtgacggtc cccgacgggc cggtgccgca ctggacccag cccatcatca accagccgga
     9661 gatcggcatc ctcggcatcc tggcgaagga gttcgagggc gtactgcact tcctgatgca
     9721 ggccaaggtg gaaccgggga acgtcaacgg gctccagctc tcccccaccg tgcaggcgac
     9781 ccgcagcaac tactcacgcg tccaccgggg ccgcccggtg ccctacctgg actacttcag
     9841 ggaacccggg cggcaccgcg tcatcaccga cgtccgccag tccgagcagg gctcgtggtt
     9901 ctaccgcaag cgcaaccgga acatgatcgt cgaggtcacg gaggacgtcg aactcctcga
     9961 cggcttccgg tggctcaccc tcggtcagat ccaccagttg ctcgccctgg acgacatcgt
    10021 caacatggac gcccgcaccg tcctgtcctg cctgcccttc tccggcccca cgcaccggcc
    10081 ggcgccgggg cccgaggacg actccttcac cgccgcactg ctgcgctcgt gccacggcgt
    10141 cggcggcgcg ctgcacccgg acgaccacat cctgaactgg gtcaccgagg tgcgcacccg
    10201 ctccgaggtg ctcacgcgcc cgctgccgct gaacgccctg gagcagtggc ggcgcggcga
    10261 gtacgccatc acccacgaca gcggccagtt cttcgaactg atcgccgtgg acgtgcgggc
    10321 cggcggcagg gaggtcggcg gctggaccca gccgatgatc aaaccgcgcg acggcggcgt
    10381 cgtcgccttc ctggtgaagt ccatcggcgg agtgctgcac gtcctgatgc acgccctggt
    10441 cgagcccggc tacctggacg tcgcggagct gtccccgacc gtgcagtgca ccccccgcaa
    10501 cttcgatcac ctgcccgacg cggcacgccc gatgttcctg gacgaggccc tcggcgcgcc
    10561 cgccgaccgc atccggttcg acgccgtgct ctccgaggag ggcgggcgct tctaccacgc
    10621 gcgcaaccgg tacctcgtcg tggaaaccga catcgacgcc ggcttcagcc accccgactt
    10681 ccgctggatg acggtgcggc aactggtcga cctcctgcgg cacagccact acgtcaacat
    10741 tcaggcgcgc agtctggtgg cctgcctgca cagcctcacc gggcagcctc cggttgtctg
    10801 aacccaccac gaccactcga ccttcggagt tgtccgcgcc catgtcacag tgccggatat
    10861 gcagcagcac ggtccgcgag ttcctcgact tcggcagcca tcccctgtcc tccgcgttcg
    10921 tcagtcccga cgcgaccggt gaagagttcc gctaccggct cgccgtcggc gcctgcacgt
    10981 cctgcggcat ggtgcagctc accgaggacg tcccccggga gcggctgtac cacaagggtt
    11041 acccgtacca ctcggccggc tccacggtga tgcacgcgca cttcgaggag acgggccgcg
    11101 ggttcctcgc gcgggaactg ggcggccccg acccgttctt cgtggagatc ggctgcaacg
    11161 acggcgtcac cctgcgcacc gtcgccgacg cgggggtgcg ccatctcgcc ttcgagccga
    11221 cgggggtcgc cgggggccgg gtgcacagcg cgttcttcga cgcggagtcg gccgccgagg
    11281 tgcgggccgc cgagggaccg gcgcaggtgg tgtactccgc caacaccctg tgcgacatcc
    11341 ccggtatcgg cgccgtcttc gagggcgccg acatcctgct ggcgcccgac ggggtgttcg
    11401 tcttcgagga cccgtacctg ggcgagatcc tggcccggac cagcttcgac cagatctacg
    11461 acgagcacgt cttcttcttc accgcccgct cggtggcctc catggcggcg tgcttcggct
    11521 tccagctcgt cgacgtcgag cggctgccgg tgcacggcgg ccagatccgc tacaccctcg
    11581 cacgggcggg ccggcgcacg cccacggcgg ccgtcgccga actgctggcc gaggaggcgg
    11641 cccgcggcat cggggaggcg gccggcctcg accggttcgg cgcggccgtg cacaccgtcc
    11701 gccgggacct ggtcgccctg ctgcgggacc tgacggcgca gggccaccgg atcgccggct
    11761 acggcgccac ggccaagagt tccaccgtga cgaacttctg cggcatcggc cccgacctcg
    11821 tgccctacgt ctgcgacacg actccgtcga agcagggaaa gctgacaccc ggcatgcaca
    11881 tcccggtacg cccggacacc gcgttccgcg acccctaccc ggactacgca ctgctgttcg
    11941 cctggaacca cgccgaggag atcatggcca aggaacaggc cttccgcgac gccggagggc
    12001 gctggatcct ctacgtgccc gaggtccaca tcgtctgagg cgtgccccgt ccgagccgtg
    12061 ccgctggggc acgcaccatg ccgtggagag ttccatgcgg gtcctgttca ccgtgttcgc
    12121 agtcaagacg cacatgtaca acctggtgcc gctggcctgg gcgctgcggg ccgccggcca
    12181 cgaggtgtgc gtggcgagtc accccgacct cgccgaggcg atcacgcgta ccggcctgac
    12241 cgccgtgccc gtcggcgatc cgctctccat ggggggcgcg ggcaaggggc ccaccaccca
    12301 gacgttccag ggcgtcagcg gcagcatggt cgaggacccg tccgacgacc cgagctggga
    12361 gcgggtcctg ggcaccttca cggtcgcctg ctcggtgcag tacgagtacc tggcgggcct
    12421 ccaggtcatg gacgacctgg tggagttcgc ccaggcgtgg cagcccgacc tggtggtctg
    12481 ggacgcgctc accttcaccg gcgcggtcgc ggcccgggcc tgcggggccg cccacgcccg
    12541 gatgctgttc gggatggact acgtggcccg gatgtacggc cgctacaccg aactcctcgc
    12601 cgcccagccg cccgagcggc gggaggaccc cgtcacggag tggacggcgg gccggctcgc
    12661 ccggtacggg gtgaagtccg ggcccgagga cacgctggag atgctgaccg gccagtggac
    12721 gatcgacccg acgccgtcgt ggatgcagtt ccgcctgccg ctgccgtacc ttccggtgcg
    12781 gctggtcccg ttcaacgggc ccaccaccgc gccggactgg gtgcgcgagc cggcggcccg
    12841 gccccgggtg tgcctgtccc tcggcatgtc cgggcgggac cagctgggcg gcgacctgct
    12901 gtccatcggg gacctgctcg acgcgctcgc cgacttcgac atcgagctgg tcgccaccct
    12961 cgacagcaga cagctcgccg gtacgtcggc gctgccggac aacgtgcggc ccgtcgactt
    13021 cgtgccgctc aacgacctgc tgccgacctg cgcggccgcc atccaccacg gcggcttcgg
    13081 caccgtcggc agcgtcctca cccacggcgt gcccagcatc accatcccgg cgccctggtg
    13141 ggacgagacc gacctcggcc gccgcatcgc ggcacgcggc gccgggttcc tcatggaccc
    13201 gcaccggccg gatctcgacg cgctccgcga ccacctgcgg cgcctcctcg acgacccgtc
    13261 cttcaccgcc cgggcagccg acgtccgcgc ggacctgctc gccacgccga gcccccacga
    13321 cctcgtaccg gagctggagc gacgggcccg ttcgtaccgc acccgccagg gggaccggtg
    13381 acgtccgtgt cgcggtgccc ccgtccgtgc ccacgcccga agggagccgg cccatgcgcg
    13441 tcctgctgac cgtgttcgcg gccaagccgc acctgtacaa cctcatctcg ctcgcatggg
    13501 cgctgcgtgc ctcgggccac gaagtgcgcg tcgccagtca gccggacgtc accgacgcca
    13561 tcacccgggc cgggctgacc gcggtgcccg tcggcgacga gctgaacctg tcggcctcct
    13621 tccgccccgg cgaggaccgg gcgggcgcgg agcagggcgg tgtgtggcag cgcctgagcg
    13681 gggtcaccga gacccgtccg gagaagctca cctggaacta cgtgctgggc acctacacca
    13741 tcggctgctc catggagtac gaacacatgg cgggccagac gatgatggac gacctggtgg
    13801 agcacgcccg cgcctggcgc cccgacctgg tgctctggga cgcgctcacc ttcgtcggcc
    13861 cggtcgcggc ccgggcctgc ggggccgccc acgcgcgggt gctgttcggc gtggactaca
    13921 acgcgcacat gctcggcgcc tacgccgacc tgctgtccgc acagccgccg cagacccgtg
    13981 acgacccgct gtcggactgg ctcaccggac ggctcgcccg ctacggcctc ccgttcgagc
    14041 cggaggacgc cgtggagatg atgacgggcc agtggaccat cgacccgacc cctgcctgga
    14101 tgcagctgcc cgtgggcgtc cctctgctgc cgatgcgcta cgtcccgtac aacggcccgt
    14161 ccacggtgcc cggttgggtg ctggagcggc cccggcgtcc ccgggtgtgc atgtcgctgg
    14221 gcatgtcggg ccgtgagctg ctgggccggg accagatgtc gatcggtgac ggggcgtcgg
    14281 ccgagccgcc cgtctcggtg ctgctgcgca cgctggccga gctcgacatc gaactggtgg
    14341 tgacgctgag caaggaccag ctcgccgcgg tctccgggct gccggacaac gtccgggccg
    14401 tcgacttcgt gccgctcaac gacctgctgc cgacctgcgc ggccgtcatc caccacggcg
    14461 gcttcggcac cgtcggcaat gtcctcaccc acggcgtgcc cagcatcacc gttcccgcgc
    14521 cctggtggga cgagaccgac ctgggccgcc acatcgaggc acgcggcgcc ggactgctcg
    14581 tggacccgcg ggaggcgtcg gccgaggtgc tgcgggcagg agtggcccgg ctgctcggcg
    14641 agccgtcgtt ccggagcgcg gcgcacgccg tccggcggga gctgcacgcc acgccgtcgc
    14701 cgcgtgccgt cgtgccgcag gtggagcggc tggtggcggt tcaccggtcg ggcagccagc
    14761 tcccgtgcag ccccagcggc accctgcgcg gcaggtggat gcgcgcgatt ggctcggccg
    14821 tgaagtcctg agcggcgagg atcaccaggt ccgccgctcc ccgccgcgga tcatggacgt
    14881 accccatgac gtatccgtcg tcctcggccc ggccgccggc cgccggcacg aacacggcct
    14941 cgccggccgc ggcgtcccgc tcgaaggtgt ggacctcgct ggtcccgcgt acggtgtcgt
    15001 gcttgatcag ggcgttgacg aaggcctcgt cgggcagcgg cccgtccccg gcgggcacgt
    15061 acgcctggta catggcggcc gtggccgcgg tgtagccgta gcggtgcggc cgggagacga
    15121 cggtgtcggc gatcctcggg aactcctgtg gccggtcgtc cagccgctgc tcgcacaccg
    15181 tgccggccga caggtcgacg gtccaccggt cgagggtgcc gtaccggctc atgcgcatgg
    15241 cggcgatgtc gaagtcggcg ggcagcgcga ccagttcgag gacgacgcgt tcgccgtcgt
    15301 cgtaggcgtt gagcgtgtgg gagacgaagg cgtccggcgc ctcgaaccag cgcacaccgc
    15361 cccccgcacg cggcagcacc ccgacgcggg acggccgccg cgggtcacgc gtgtacggcg
    15421 tcctcgcgcc ggtgctcatc gcctcgggag agaacaccac cggggagtcg tagacgacga
    15481 cccaccgctc ggtgagggcg aagtcgtgca tcatcgggtt gccgtcgaga gggatctccg
    15541 cctcgtggac gagccggccg gtcccgtcga ccaccaggtg cctggccgtc cgacgcccgc
    15601 tgaggtaggc caggccgtgc agttcaccgg tcagggggtc gagcttggtg tgggcgccca
    15661 tggtgaagcc gggtcggaca ccgccgagcg cgtacggccc gacggtgtcc agctcggcgg
    15721 tcagctcctg ggggcaggcc cagtcctcca tcagcgccag ggtgcggccg ccgtggccga
    15781 tgacgtgggt gttgcaggcg aagtcgatcc cgatctcgca agcggcgccg ccggacggct
    15841 cgccgagcag gccacgcacc tgctccgagc ggacccagcg attgcggtac cactcggcgc
    15901 gcccgtcgcg gatgcggaca ccgtgcacca tgcccggccc cgacatccag tggtgggccg
    15961 cggggtcctc gacgccgagg gcgttgggcc cgatgcgcag gtagcggccg gccagctcgc
    16021 cggggacacg gccggtgacg gggaggtcga aggcggtgac ctcctcgtcg accggggcga
    16081 agggaccagc gagaaagcga ctcatcggtg cggtgctcct gacggttcgg tgcgtgggcc
    16141 ctgcccggcg agcgagcccc gtgtcacggc tcgggctcag gagaaccggc gccggaagag
    16201 ccggttggac agcggcacgg cgagggcgat gatgccgccc caccagagca ccgcgatcca
    16261 ggccgcgttg cccaccggct ggtcgagcag gagcgcccgc acggcgtcga tgaccgcggt
    16321 gaccggctgg tgctcgacga agacccgcag accgggcgac atggtctcgg tcggcgcgaa
    16381 cacgttgctc gcgtagggca ggaaggtcag ggtcagggcc aggccgctgg ccccctcggt
    16441 gctcctggcg agctgcccga agagcgcgga gatccagccg acggcgacgg cgaagagcat
    16501 gagcagcgcg aacgcggcca gatactgcag gacgccggcc gaggggcgga agcccacggc
    16561 gaatccgatg gcggtgagca ccaccaggcc gatgagggcg cgcatcaccg ccgccacgat
    16621 gtgcccgatg acgaccgagg tggcgagggt ggacatcgac cggagccggt cgacgaaccc
    16681 ttcctgcatg tcgaggaaga cacccacggt ggtggagacc gagatgaggg tgacaccgat
    16741 ggccaggatg cccggcacca ggaagttggc gtaggaggag ccgcccgcgt cgacggcgcc
    16801 gccgagcatg tagcggaaca tcagcatgag cacggtgggg atcaggaccg cggtcgcgat
    16861 ctcctcgggc tggcgcagga tgtggcgcac gtagcgccct gcgaggaccc gggcgtcgct
    16921 gaacgcccag gcgatcctgg agcccccgcc gcacgggcgg acggcctcct cgtaggtggt
    16981 ggcggtcgtc attcgctcct gcttcctacc gtttcggcgc cggccgccgc ggacgcggcg
    17041 ggcgggttga cgctccgggt gccgggctgc ccggtggcgg aggtgtgctg ggtgagggtg
    17101 aggaagacgt cgtccagcga cggtctggcc acatccaggg agccgatccg cgcccccgac
    17161 cgccgcagct cgtccagcgt ccggacgagc agttccaggt cgtcggtggc gacgctcacc
    17221 gtgcgcgtct cgcggtccca ctggaggtgc tcgtccccgg cccggctcag ggcgtcggcc
    17281 ttgaggaagt cctcgtcggt gtcgaaggtc acctgcatcc gctcggcgcc gatgcgctgc
    17341 ttgagctcgg tggccgtgcc ctgcgcggcg atgcgtccct cgtcgatcac ggcgacccgg
    17401 tccgcgagct ggtcggcctc ttccaggtac tgcgtggtca gcaggatcgt cgagcccttg
    17461 gcgagcagtt cccggatgac cccccacagg gtccggcggc tgcgcgggtc gagcccgacg
    17521 gtcggctcgt cgaggaagag caccggcggc gcggtgatca ggctgatggc gaggtcgagg
    17581 cggcgccgca taccgccgga gtaggtcttc accggccggt ccgcggcctc caccaggtcg
    17641 aactgttcca gcagttcctc cgcccggcgg cgggcggccg gggcccgcag gtgctggagg
    17701 cggcccagca tcaccaggtt ctcccggccg ctgtgcacgt agtccagggc catgaactgg
    17761 ctgaccagcc cgatggaccg gcgcacgccg gcggcctggt ggaccacgtc gtgcccgtgg
    17821 accacggcgg tgccgccggt cgggccgatg agggtgctca ggatccggac cagggtcgtc
    17881 ttgcccgctc cgttcggccc gaggagggcg agcatggtgc cacgctcgac ctgaaggtcc
    17941 acgcccttga ggacatgcac gtccccatag gacttggtga gacccgagat ctcgatcgca
    18001 tagctgttgg ccacaggtcg actccacaac tgtgtacgtc acacactgac ccgcgtatcc
    18061 tatacacagt tacaatgagg cggtcaacag acggcaacgg gaccgacgag gggtacacgg
    18121 gatggcagcg gagcacgacg gggccgaccg gctgagccgc agtctggatc tgctctgggg
    18181 ctccaaggac aaaccgagcc gcggccccaa gcccgcgctc agcctggaga agatcgtgcg
    18241 cgcggcgatc gagatcgccg acgccgaggg catcgacggc ctgtcgatgc agcaggtggc
    18301 cggccggctc ggcttcacca ccatgtcgct gtaccggtac gtgcccggca aggaccagct
    18361 cgtcgacgcg atgatggacg cggcttcggg cccgccgccg cagctgcccg ccgccgaggg
    18421 gtggcgcaac cggatcgagc ggtgggtgca ggccctgtgg gtgcgctatc agcagcaccc
    18481 gtggatgctc caggtgcagg cgagcggccc gcccctgggc cccaaccagc tcgcgtggct
    18541 ggagagttcg ctctccgcac tggacggcac cggcctcacc gccgaggaga tgctgttcgt
    18601 gagcctcttc ctcaacggag cggcgaccgg cctcgcccgg cactccaccg ccgcggccca
    18661 gaccgccgcg cacaccggcg tgcccgccga gcgggtcggc gcggactacg cgcagatcct
    18721 ggagcgcgtg ctcgacaccg accgcttccc gacgctgacc cgggtggtgg cggcgggcgc
    18781 cttccggccg ggcgcgggtc cgggcgaagg cacgacgcac gacctggagt tcggactcca
    18841 gcggctgctc gacgggatcg agaggtacgt cgaggagcgc acggccacct gtcccttggg
    18901 cacatccgcc tccgcgaccg gaccggtgtg aattcgggat tgggtaagga tcgcagaaat
    18961 cgttcactcg actgccgcgc atccgacgga ctaggcagac gttacttcgg atatgaccga
    19021 ggaaaacggg gaaccgacgg cgcttggccc gtatgcctgc aggcccggca gagatcactg
    19081 tccgtcaccg ggcggcagaa ctctgaccag aggcgggcgc cccgtcgctc tccgtgcgac
    19141 caccccggtc ctgcggcgcc tgcgcaccgg ggcggagtga ccggcacctc gtgtacgaag
    19201 aacacactca cccctggcac acccatcccc ccatgccgta cggcgagggc tcgttccacg
    19261 ccaccggtac gggcacgggc cggcaccggg cgcccgagca ggccttccag gagaccctgg
    19321 tgccgccgga gcccggctgg gacccggccg aggagctggc gttcctgctc caggacgcga
    19381 tggagcagca gaccggcgcc ccctttgccc ccgacccttc ggcgctcgca cccgccccgg
    19441 gcacaccgct gagcaatctc caggagatca cggcggaact gcccccgttg agggagtccc
    19501 cgacgagtca ccgcagggtc cgcagaggga gaaaggtgag ccggctgcgt gcggcgagcc
    19561 tgttcgtcgc cgcgctcgcc gcggtcatcg ccgcctccgt gagcctgttc ggcggcatgg
    19621 tggcctacga accgctgcgg ctggcggccg tgacccggac ccggggcagc gtcgtgtcct
    19681 ggtggccgct gctggtctac gggccctggc tggtggcctc gctggcggtg ctgagggccg
    19741 cgttgcacca gcgccgggcg gtgcactcct gggccgtcgt cctgctgttc tccgccatcg
    19801 cgatgttcct gtgcgtcgcg gaggcgccgc ggacggtcag cgacggcgcg gcggccgccc
    19861 tgcccggcct ggcctcgctg gtctgcttcc agcaggtcgt ccggcagatc acgctcaccc
    19921 gtccgccccg gcgggcggtg ccgcggcacc ggcagcgcgc cgcggtcact ccgggtgacg
    19981 acccgtcggg ccgggcggcc tccgacgcgg tgtcccttcc gcagcagcgg cagaatcatc
    20041 cgcgctcgtc acggccgggc ccgcgccccg ggaaaagaat ctgaaccgga gcttctggaa
    20101 gtggccggac cgggcttccg tgcattcccg gaggtgcgcg ggaaaaggaa tgcggaagtc
    20161 ggtcccggcc gtgtgtgcgg gcgggcccgg aggccgccgg gcgggatcag gacgccgtca
    20221 gggtcacgtc ctgcgtctgc cgggcgtgga agctcgggag cggcacgatg cccatcgggc
    20281 gcagctccat caaggtggcc tcgacctggg ccgcgccggg cttgaggacg acctggtcgg
    20341 gcgtgccggt gttggcccag cggtgctcca gtccgtcgca gaccgcgcgg gtgccgccga
    20401 cgccgtaccg gacggacggg tcgctctggc tcacggagga gctgacgaag accgggccgg
    20461 tgcccccggt gcagcggtag gtgccggtga gggtgacgct gccgtcggcg gcgatgcggc
    20521 cgacggggtc gacggtcacc gactcggcgg cgagacgggc gtcgtggggc gcggcgggcg
    20581 cggcgggcgc ggtgagcagg aggagggcgg caccggcggc cgtggcgagg gcggcggatc
    20641 ttacgcgcat gggggaatct cccggtcggt cggaatgagg ggattccact ggtaccgggc
    20701 gaaggggcgg gcggcagtga ccgtcacccc ttcggtggcg agtccgcgtc ggcccgccgg
    20761 cctcagcccg gccaccgtcg tggaaccgtc gccggttcgt ccgggtgttg tcacgctcgc
    20821 gcccgggctc ttggcggcgg cctcccggcg ggggcacggt cggtgcacgc gacggtcccg
    20881 gcgaagggac ggtccttcga cgtggaggtg cgccatgtgt acccgccggc cttcctgccc
    20941 cgcggccgcg tcccccgagg cgcgcgccga gggcgcgcac gtcgtcgccg cccacccgga
    21001 gcaggggtgg aacctgctgt gcgacggcac gatcgtcttc gacgacaccg gtgaactgcg
    21061 gcccgacggc caggccgtcg ccccgcgccg gctgccgggc ggacccctgg ccgtggccgc
    21121 ctgagcgacc gcggggcgcc gggcggcggt cagggccggc cggcgacgaa ctcccgcagc
    21181 agggaggcga gcagttccgg ctggtcctcg gggatcagcg tccgggagtc ctcgacctcc
    21241 accagccgcc cccgcgggag gagttcggcc aggcgccggc cgtgggcgcg gggcatcatc
    21301 aggtcctcgg tcgcccagac cacgagcgcg ggccggtcga accgccgcaa tccctgggcg
    21361 gcttcgagga gttcgtcgcg gcggacgtgc gtgttgtagt gccggaagtc gcgccggacc
    21421 gccgggtcgg tgcgcagcgg gcgcagccag ccgtccacga cctcgtccgg tacgggccgc
    21481 ttggtcaggg cgccgatgcc gacgggcagg cggcgcaggg gtgcgaggcc cagaacgcgg
    21541 accagcgcgg acactccgcc gggcgtccgg caggcgaggc cgatcagctt tcccggcagg
    21601 cccggcgggt agttgtcgaa cgcctcgcac gcgacgagcg ccagccgcgc gagccgctcc
    21661 ggatgccggg cggccaccgt ctgggcgcgt ccgcagtcgt tctcgacgag ggtgacgccg
    21721 gtcaggtcga ggcggtcgag gaactcggcg atcagctcgt tgaccaggtc gggcgtgggc
    21781 ggccggcgca tcgggcggcg gtgggcgccg tagggcaggg tgggcgcgat cacccggtgg
    21841 tcggtgcgca ggtcggcgac gactcctcgc cagacggtgg cgtcgtggac gaggccgtgg
    21901 aggaggacga cgaccgggcc gtcgccgccc gtgtcctcgt actcgatggt gcccgcgctc
    21961 agttcgatgt ccggcatgcc ggaagcgtag gggccgcgcg cccgctacgg cagtacggcg
    22021 aagccgtcga gttccaccag cgcccgttcg tcccagagcc gtacgacctc cacgaccgcc
    22081 atcgccgggt agtcgcggcc ggccagctcg cgccaggtgc ggcccaggtc ggcggcgtgg
    22141 gtgcggtagg cggcgacgtc ggtggcgtag acggtgacgc gggcgaggtc ggcgggggtg
    22201 cccccggcgg cgcgcaaggc ggtgaggagg ttggtgaggg cccgttcgaa ctgggcgggg
    22261 agggtgtcgc cggtgatcgc gccgtcggtg tcgagggcgg tctgcccggc gaggaggacg
    22321 acgcgggtgc cggtggcgac gacggcgtgg gagaaaccgg tgggcgggga cagttcgggc
    22381 gggttgatcc gttcggcggt catgctccgg tctcctcggt cgtctcggtc gtctcggtcg
    22441 tctcggtcgt ctctgtcgtc gtggcgtcgg ggtggtacgt gcggtacagc tccttggcga
    22501 cgatgccgcg ctgcacctcg ctcgcgccct cgtagatgcg gggggcgcgc acctcgcggt
    22561 agaggtgttc gaggaggtgg ccgcggcgca gggcgcgggc gccgtggagc tggacggcgc
    22621 ggtcgacgac gtactgggcg gtctcggtgg cgaggagctt cgccatcgcg gcgcgcttcg
    22681 ggacgtccgg ggcgcccgcg tcgtacgccg tcgccgccgc gtacaccatc aggcgtgccg
    22741 cctcggtgcg cagggccatt tcggcgacct ggtgggagac ggcctggagg tcgcgcagcg
    22801 tgccgccgaa ggcgtcgcgg gcggtggtgt gcgcgagggt cgcgtcgagg gcggcctgcg
    22861 ccatgccgac ggcgaaggcg ccgacgctgg ggcggaacag gttgagggtg cccatggcca
    22921 cccggaagcc ctcgtccggt gcgcccagga cgtcgtccgc ggtgacgggc acggcgtcga
    22981 aggagagggc gccgacgggg tgcggcgaga gcatgtcgag cgcgctgccg gtgaggccgg
    23041 gacggtcggc gggcacgagg aaggcggtga cgccgcgggc gccggcgccg ggggtggtgc
    23101 gggcgaacac ggtgtagaag tcggcctcgg gggcgttgga gatccagcac ttctccccgg
    23161 tgagccgcca ggcggagggt ccgccgcccg gccgggggtc cggttccgca cgcagggaca
    23221 gcgccgccgc gtccgagccc gcgccgggct cgctgagggc gaacgcggcg accgcggtgc
    23281 cgtcgctcac gcgggggagc cagcgggcgc gctgggcctc ggtgccgtgg gtgtgcacgg
    23341 ggtgggcgcc gaggccctgg agggcgaggg cggtctcggc ctccgtgcag gcacgggcga
    23401 gggactcgcg catcaggcac aggtcgagcg cgccggacgt gaacaggcgg gacagcaggc
    23461 cgagggcgcc cagttcggcg accagagcac ggttgacgcg gcccggctcg cccttctccg
    23521 cgagcgggcg cagccgttgg acggcgaggg cgcgcagctc ttcgcaccag gtgacgtgtg
    23581 ccggttcgag cgagaatgcg gtcatcgccg gtcccttccc ctgccgtcct gccctccggg
    23641 tccacggccg aggctatcgc gccccgttga ctgccgtcac cgacacgata cgctcgtggc
    23701 gcgagcccac cacgacaaag ggggcgaacc gccatggccg atgcgcgcca cgcggacccg
    23761 caccgctccg cccatgtcga caccttcgcg cgcgaccacc tgccgccccc cgagcagtgg
    23821 ccgcagctcc tcttcgagct gccccggctg cgctacccgg cccggctgaa ctgcgccgcc
    23881 gagctgctcg ccggcccgcc cgacgaccgc cccgccttcc gcaccgtgtc cggggacacc
    23941 tggacctacg gcgggctccg cgagcgcgtc gaccggatcg cgcacgtgct gaccggcgac
    24001 ctcggtgtcg tcccgggcaa ccgggtgctg ctgcgcggcc ccaccacccc gtggctggcc
    24061 gcgtgctggc tggcggtgct gaaggcgggc gcggtggcgg tcacggtgct cgcccagcag
    24121 cgcccgcacg agctgcgcgc gatctgcgag accgcccggg tgcggcacgc gctgtgcgac
    24181 gtccggtccg tcgacgacct cgcccgggcg gacgtcgcgg gcctcgcgat cacgccgttc
    24241 ggcggggacg cgccggacga cctgcgccgc cgtacggcgt cgggcgcggc gcccggcacg
    24301 ccgtaccggg ccgtcgacac ggccgccgac gacgtggcgc tgatcgcgtt cacgtccggc
    24361 accaccgggc ggcccaaggg ctgcatgcac ttccaccgcg acgtgctggc gatcgcggac
    24421 accttctccg agcacgtgct gcggccgcgc tccgacgacc tcttcgcggg cagtccgccg
    24481 ctcggcttca ccttcgggct cggcgggctc gtggtcttcc ccctgcgggc cggtgcgagc
    24541 gccctgctgc tcgaacgggc gggcccccgg cagctcctgc cggccgtcgc cgagcaccgg
    24601 gtgtcggtgc tgttcaccgc gccgaccgcc taccgtgcga tgctcgacga gctggacggg
    24661 tacgacctgg gcagcctccg gcgctgcgtc tcggcgggcg agaacctgcc cgcggccacc
    24721 tggcgcgcct ggtacgagcg caccggcctg cgcgtgatca acggcatcgg cgccaccgag
    24781 ctgctgcaca tcttcgtctc ggcggcggac gacgccatca ggcccggcac g
//
