LOCUS       NZ_BBOK01000007        23852 bp    DNA     linear   CON 17-AUG-2024
DEFINITION  Streptomyces sp. NBRC 110030, whole genome shotgun sequence.
ACCESSION   NZ_BBOK01000007
VERSION     NZ_BBOK01000007.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. NBRC 110030
  ORGANISM  Streptomyces sp. NBRC 110030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Katano-Makiyama,Y., Hosoyama,A., Hashimoto,M., Tsuchikane,K.,
            Uohara,A., Kitahashi,Y., Ohji,S., Ichikawa,N., Kimura,A.,
            Yamazoe,A., Komaki,H., Igarashi,Y. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Streptomyces sp. NBRC 110030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 362051)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 97x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417675.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,152
            Genes (coding)                    :: 7,019
            CDSs (with protein)               :: 7,019
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 45 of 133
            Pseudo Genes (incomplete)         :: 107 of 133
            Pseudo Genes (internal stop)      :: 8 of 133
            Pseudo Genes (multiple problems)  :: 23 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:33:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 338199
            Orig. end                         :: 362051
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBOK01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23852
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23852
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23852
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:16457](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16457
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(385..398)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            1610..3121
                     /locus_tag="APK71_RS19835"
     CDS             1610..3121
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491180.1"
                     /locus_tag="APK71_RS19835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_107094305.1"
                     /transl_table=11
                     /translation="MPDSALTARPTPADHRRRRPPVDAIMLRRARRAVALPLVFLATVL
                     GVAFALWPVSAVGPGWVLAGLVCGLTGVTLVAAHGARTVAAAVQSAAEESRATALNAVT
                     GAAAAVEKSVRWSADELCRGKRPALPDLQASPTSGPNAEIDNVLSALQAQAIASLTRVH
                     DESQSVVLLEVLRRLAMREHALVGKALEALSRLEMLTDDPELLAKIFEIDHLVTRMRRQ
                     VESTAVLGGQSLRSVRQAVPVTTALRGAVSEVVSYPRVAVAAGSVGAELGLPGHVGPDL
                     THLLAELIENACECSDPATRVMVRAQRVPHGLAIEVEDRAIPMPPQTRSQMNHLLKAPD
                     EVDVSGQVRAGQLGLLVAAKIAQSHGLSVLLQENVTGGTTALVVIPARLLVAMPSVEDA
                     GALPPEEVRPSQQPQQVAAAPAAQRTGQAARPGAAGAPIEAGRSAEPPTLPTRTHRTEP
                     FRPPREREQAPVSGATPGLAAAFRNGLQAGGTASPPPASTDHPTP"
     gene            3190..3705
                     /locus_tag="APK71_RS19840"
     CDS             3190..3705
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031324.1"
                     /locus_tag="APK71_RS19840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_055468648.1"
                     /transl_table=11
                     /translation="MNTHPAMSNVTDGTPASATTPSGQRDNMAWLLRQFVNETPGALHA
                     VLLSRDGLRLLDSDVDKDWADELSAAFSGLASLAANVTGPSHKKRAPRQVIIERADCLF
                     FVQSAGRSAAFDTHPGNERGEVDTILAVIAAGNCDAGAVGFEMGRLVAKFAPYMLIPVR
                     VGTGGEVR"
     gene            3702..4097
                     /locus_tag="APK71_RS19845"
     CDS             3702..4097
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491176.1"
                     /locus_tag="APK71_RS19845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_055468649.1"
                     /transl_table=11
                     /translation="MTTYGRTAEESVFVRTYTVVRGRTKPRHLLGLETVLEAGQGRPGP
                     AQAAECEEILSLCRERRRSVVELAGRLGRPVTAVKVLVSDLLDADALVVPLTQSYAGSG
                     PSTQLLAAVSAGLKRKWPDAVTYPQAG"
     gene            4153..4737
                     /locus_tag="APK71_RS19850"
     CDS             4153..4737
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491174.1"
                     /locus_tag="APK71_RS19850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_055468689.1"
                     /transl_table=11
                     /translation="MLKIVIAGGFGAGKTTAVGAVSEITPLSTEEYLTEASADVDNLAG
                     IEAKQTTTVAFDFGRLSLPDAPIPLELFLFGTPGQDRFVDLWYDLSRGAIGAVVLVDTR
                     RLESSFAPVSFFEDIGLPFVVAVNEFDGAHRYHPEQVRTALKLPSAVPVVTCDARDTNH
                     VAGVLLALVDHAVNNATSSRAGHTSTTLQDA"
     gene            4737..5378
                     /locus_tag="APK71_RS19855"
     CDS             4737..5378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325325.1"
                     /locus_tag="APK71_RS19855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GAF domain-containing protein"
                     /protein_id="WP_055468650.1"
                     /transl_table=11
                     /translation="MSQHPSDPYRTPQTTQPARSLPRRDIRDTNRGPFTPPATTLTSQR
                     PQQSLELAQRYELLNRLGVSPVANEDFDDLARDMATQAGFLYGFVNLFLEEQTFVGLHQ
                     PPADSGFVIVGRTMSRDHGWCPEVMARKKALPLHDVHASPRFSGNAVVDAVGIRSYFGA
                     PLMHDSGTVLGTVCVIDPEKRPLAEARRLRDIVINASAQVMDHIARAPVR"
     gene            5464..6717
                     /locus_tag="APK71_RS19860"
     CDS             5464..6717
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325326.1"
                     /locus_tag="APK71_RS19860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_055468651.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-21, bitscore:
                     71.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.3e-20, bitscore:
                     66.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-31, bitscore:
                     104.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATPTTPPPALHPYLTARHDLLWQEADAFAAEHVVPRATRMEAA
                     PGRVERKVASLMAAKQWFAVTVPAAFGGLGAGHVAKTILVHRIARVSAAAAAILQATLI
                     PVGALLHFATYEQKGRWLPQVADGSLLLSIAVTEPLAGGHIGGIETTAERVGNEWVITG
                     SKIHIGNSHLAGVHLVVARTAAPGVSTSQALTAFMVEADRPGLSVPDHRPGLGLHGFSA
                     GRLDLDHVRVPDDNVVGEVGQGLAVAQSSSILYGRPNLAAVSLGIHEAVVDTTTSRLKT
                     RPRYRGALSDLPVLRDRIGGMEARLRAGRILAYQSVHLLDRGLPCDTDLINSKYLGHQW
                     AIHSAQDAMELHGAHALDGDYVLQRLWRDIQHTYPPAGTGEVQRIRLADAAFDEDHIQW
                     SEHLAAEAAWARPDPTAA"
     gene            6855..7328
                     /locus_tag="APK71_RS19865"
     CDS             6855..7328
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143021.1"
                     /locus_tag="APK71_RS19865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_234353189.1"
                     /transl_table=11
                     /translation="MTTKAPITPLTPTLQRVAQHLANGLTAQEIATQTGLSPVTVRQYL
                     RDIRESLHCPPRCKPPVIVHRLFTTQQVASPTADRPAPTLSPVQRLLLRAVAEHSDPRD
                     IAIAAKLAPADQRAALDQLLADTGARDTAHLVILAHGWKLLPTDAAARSGACQ"
     gene            7973..8551
                     /locus_tag="APK71_RS19875"
     CDS             7973..8551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491163.1"
                     /locus_tag="APK71_RS19875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6624 domain-containing protein"
                     /protein_id="WP_055468654.1"
                     /transl_table=11
                     /translation="MTTDEPQRLDLARELIARANESAVHRAKRVRNQLDAVQLGQGRHT
                     DHANTKFLRRVLGEYEWPGHRLVGPAAARAAWSIALHSDHDLTLQRAATILLRRAVQVG
                     DALVQHWAHLHDRALITSGRAQEYGTQLLLTADGIGLCPLRAPASVDKRRATVGLPPLA
                     VALKAVRRRYTPDSSADEAPTVVLAGIAA"
     gene            8624..9091
                     /locus_tag="APK71_RS19880"
     CDS             8624..9091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491161.1"
                     /locus_tag="APK71_RS19880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6082 family protein"
                     /protein_id="WP_055468655.1"
                     /transl_table=11
                     /translation="MKLTTAVLAAGAAVSLTTAVVGATRLRQEARHQTERNEVFLTRNQ
                     LDWLAQMSTNPDLAKLWAPEDMDVEEYMQLLAANRLICILSVRDRLGFVRSGHLPWYAA
                     KLMESDVCRRYWQRFGGLRAEEAEGDEQGEHFTRVLDRAAKNYPSAQPVAA"
     gene            9126..9470
                     /locus_tag="APK71_RS39405"
     CDS             9126..9470
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="APK71_RS39405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_079080609.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.3e-13, bitscore:
                     45.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPNSSAGQQIPCLERWPRRARPAQSHSCRPPGRAGRTATHRID
                     EFHHTDQEDPRDFQGDHQRARAASASAAQDPFDLDISVIESGGTVGASIASDGGCGSTC
                     GGNACISSGS"
     gene            9577..9708
                     /locus_tag="APK71_RS35805"
     CDS             9577..9708
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491158.1"
                     /locus_tag="APK71_RS35805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_063788268.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.7e-18, bitscore:
                     59.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHDEFDLDITVLESGDGQAVLINLTDDGCGSTCSSPCATNVA"
     gene            9741..9920
                     /locus_tag="APK71_RS19890"
     CDS             9741..9920
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491157.1"
                     /locus_tag="APK71_RS19890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_055468657.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.5e-12, bitscore:
                     40.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKANTIKGQMQSPAATAGGDAFDLDISVLESGDGSATVINLTDDG
                     CKPSCNGSCATNVA"
     gene            10001..13102
                     /locus_tag="APK71_RS19895"
     CDS             10001..13102
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031312.1"
                     /locus_tag="APK71_RS19895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_055468658.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6e-202, bitscore:
                     666.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.9e-17,
                     bitscore: 56.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-28, bitscore:
                     95.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSRKDGPLYRCADAALVRAARYSRLPLPAWPDLTDETPGRQVRW
                     QAWLRDIWALHEAADSIEQASPLLAQQVATLCSAASPETRQLRRALVSVMRYLLRMTGR
                     ATPNGLFAGIAPASFGERPEWSWGEWHRPVVRADGDWIADLIARLEANPELLRHLRVIA
                     NNTIFVRGDRLIVPYPPRSRRTEDSPAAEVSLRYTGAVRIAVVAAASPVPVHVVVELMR
                     AEFPDVPAGQVEGLVSSLVERGVLISGLHASSASLDALDHLVQQVEAADAPSAADLVAD
                     LRAVRDAIAQHNQVLAPTDGRRLRTALRQKMTALSTVKTQPLTLDLRMDCSLTLPRQVA
                     REAEQAATVLARLTAYPFGTPAWKDFHNRFFERYGINALVPVRDLVDPDVGLGFPAGYR
                     DAEPEKREALTAREQQLFALAQAAVLDGRDEISLDEDLIRTLTVGDRHAPQVPAHTELR
                     FHIRATSQEALESGDFVIHGIAPSRGIGTTIGRSLGLLAPDDQARVGALLKELPVNMPG
                     SIPTQVSFAPLNRGGTNVTRVAEVLPTVISLAEHRQVDERTITLDDLAVGCDRRRLYLV
                     SLSRACLLDPMTLHALDLRGHTPPLARFLTEISRSQTAVLTVFPWASATALPYLPRVRH
                     GRAILSPARWRLERSELPDRRASWEEWHKAADGWRARRRVPDHVTLAEGDQLLPLDLSE
                     RAHLALLRTHLDTHESAILTEAESDGGWFDGRSHEIIAPMTAVRPPQWPAVPPITTDQL
                     ITRDHGHLPGAASWLLVKLYGHVERQPEILADHLPALFEQWDAPPTWWYMRYRDPRWHL
                     RLRISVPSEQDFALTAERVSAWANGLRRAGILADMQFATSYPETGRWGTGPLMRLAEDV
                     FAADSRALAVQFSQSTRPHRQVLAAANFVSLAAAFTGSIAAGMDWLIAHGRITDPRPTD
                     RAMRGQAVRLADPTDGWAALRAAPGGAAIASAWSERDEALARYRRKLDTSGGGIDPDLV
                     LDSLLHAHHIRAVGIDKDDERMCVRLAHAAAMAWTHRGDHHEPA"
     misc_feature    10466..10468
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10481..10756
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_APK71_RS19895_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.10E-18"
                     /identifier="RREFam001.1"
                     /label="APK71_RS19895"
                     /locus_tag="APK71_RS19895"
                     /protein_end="252"
                     /protein_start="160"
                     /score="56.1"
                     /tool="antismash"
                     /translation="VIANNTIFVRGDRLIVPYPPRSRRTEDSPAAEVSLRYTGAVRIAV
                     VAAASPVPVHVVVELMRAEFPDVPAGQVEGLVSSLVERGVLISGLHA"
     misc_feature    10922..10924
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13089..14348
                     /locus_tag="APK71_RS19900"
     CDS             13089..14348
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491155.1"
                     /locus_tag="APK71_RS19900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_055468659.1"
                     /sec_met_domain="LANC_like (E-value: 1e-63, bitscore:
                     209.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLRDSARVTADTIAERLASPEDVRGLHHRQGWWPQSLAHGAVGV
                     ALLHIERARTGQGPWQRAHDWLACAAAEPAVGGPDSHLYYGAPALAFALHAASDRPGRY
                     ARALDTLDRYVTTAIRDRLADAHARMDRGEMPALAEFDAIRGLSGMGGLLLHRDVHTDV
                     LREILTYLVRLAEPVKHDGEVLPGWWSHLAPSGTISPQYPEGHANNGVAHGIGGPLAVL
                     SLAARRGITVDGQLDAITRILAWLDHWLQDGPAGPWWPYWITREELRSGTTGPGPSRPS
                     WCYGTAGFARTQQLAALAREDPARQHAAEFALLRAMTDPGQLDATVDVSLCHGFAGLAR
                     ITQLAAADALTPGLAECLPRLLAPITDTAPGTLADSLFAPPGGGDIGLLEGAAGTALAL
                     HAFHTGMPSASGWDSCFLIN"
     gene            14367..16457
                     /gene="fxlM"
                     /locus_tag="APK71_RS19905"
     CDS             14367..16457
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325335.1"
                     /locus_tag="APK71_RS19905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_055468660.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.5e-28, bitscore:
                     93.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 5.9e-44, bitscore: 144.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAADEWPQRLIRFTDWSRAEATAVEHLLPVLIAQEAELAQWSFLR
                     KYPWWRFRYRAAGPDSAKALDAALDELVDASVLASWRRGIYEPEETAFGGPAAMKIAHT
                     LFHYDSRHLLEEAARQQAVSGPQLGRRELAVLLLSVAMRAAGLDWYEQGDVWAKIVAER
                     PRDEVHSPQRHRAAVHRLMTVDVSTTSRSVTQGRLAPLAEWIATFEWFGQQLADLNRQG
                     RLERGLRAVIAHHGIFHFNRLGLPAQDQHALSTLAKEAVMGTSDNAASTRTEGTPSTTV
                     NGVNSDTVEAPSADRLRAQLIDHLVETGCVRTSRVEEAMRTVPRHLFVPNAPLVKAYSN
                     APVDTKFDGSGRSISCASQPDIVAMMLEQLDVQPGQKVLELGAGTGFNAGLLGYLVGET
                     GHVTTIDVDDDIVAGARGGLAAAGIHNVEVILKDGAVGHSPNAPYDRIEATVGAHGVPH
                     AWLDQLAPGGRLLTPLRLRGSVSRSIAFENQGGAWRSVGSQMNTFMPLRRGIADDPRVF
                     VPLDPDHTVTLVTNGDQQVDADALSDIFRQPCTEVWTDVTFRGPESAEYLELWLACAMP
                     NGLSRMPAKGEAIEKGLVTAPYPSSTAVFEGGTLTYLTRRPYAKKAPDGATLYEFGVIG
                     HGPDAQALASDVADQLRTWNQSFRALDVGFEIQPLDATPLAPKPGRFTFDNPLNRIVIE
                     WQ"
     gene            16459..17622
                     /locus_tag="APK71_RS19910"
     CDS             16459..17622
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325336.1"
                     /locus_tag="APK71_RS19910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_055468661.1"
                     /transl_table=11
                     /translation="MDVSQIAKRFPLVARPRPACPPLAERIREITDLAAAAERDDNVTS
                     ATVALNKAALIASDCGMPNLARALCWRHAEAVLRAQPLGAQEARHALEPLVNLARLRIR
                     DGDGPGAYHLLDSLTRAVRSQSETVIDGHTTSFQHLTTSAGDHQQVCQWLWTVLLGDGT
                     RALVAAGEWDRALTHSKQHRGIGQRLLDGRQVEVLVRCLGEQPSNALKFLHESTLAEPW
                     EHSVSAALTVLCHRAADEQPVELIAKMVQRYLALGSAPELAVFRSRVGLVVLDLSPRSR
                     RSEAMHRLASEATARPDGYIARDVLAHPVGREGLSQDERRTLAAAVTSAGLGLGTIPAP
                     LAQAMRDASTVAVGVWERHANRQANAPSASSRPDRKPAPCPPTATRP"
     misc_feature    16810..16812
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17638..17653
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.07"
                     /tool="antismash"
     misc_feature    17827..17841
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            17997..18899
                     /locus_tag="APK71_RS19915"
     CDS             17997..18899
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978526.1"
                     /locus_tag="APK71_RS19915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_079080610.1"
                     /transl_table=11
                     /translation="MPDDIQQAIPAIPRPTGGNGPQEHHMHLLGRYYRQVEAGRKTIEV
                     RVATPNKRTIAAGDTVVFHDRDTGRELDVTVQRITSYPSFEDLLSSEDPAHIDPDEPPG
                     ELLAALRSIYPPVKEALGVLAFTFDHRPARPGRPMPMTAEEYAQTVPHHTVYGCLYIRD
                     EHDRPIQLRSVYGSRLWQFPGGNLDALGEDPLQTARREAVEETGLELGLGTPPLLLTHF
                     LHAGPRLPLNKVGFAFDGGRQSADQLDRIRLAPAEHDMWAVHDLATWQELMAPRAFARL
                     DAVEQARRGEGPAYLVTRT"
     gene            18981..19973
                     /locus_tag="APK71_RS19920"
     CDS             18981..19973
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="APK71_RS19920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_159042880.1"
                     /transl_table=11
                     /translation="MSTQDRVRLMLWNLQRDGGPEPRPGVLPERWRQGYEEVLKPQRPD
                     WLAMLELKYSQTRPDVAPAEKHAAERRFTAAQQILGMRGFRAAVGQRTNPTGVFIREAV
                     FPSARQRHHPVGHSAPPTHVELRLAEAPDVPVITASFHSAFCNPAQRRSEAMDLTELVD
                     KVKAHHPNPAGGHAACWLFGDTNEYPVPIGEQVPAIDWSSPEVTDIVHRRHRAIKQPDG
                     TWASCTAVDEIMLDCGMHDPARWAAHRLGQTTALAATAGYAAVGQGGPRRIDRGYLDAW
                     SVQAVENVRVLDTTGLSDHHAVIVDLSRRKLIEGLHRRTSAIAPWSLVV"
     gene            complement(19984..20208)
                     /locus_tag="APK71_RS19925"
     CDS             complement(19984..20208)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="APK71_RS19925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_055468664.1"
                     /transl_table=11
                     /translation="MSDFDAVMLSYDEPIADRLHARVQRVLGTRVKRLHGVRGMRRAYR
                     LAAEVTDSEQFLLGGHGCLLSKEGGVRCA"
     gene            complement(20205..20396)
                     /locus_tag="APK71_RS19930"
     CDS             complement(20205..20396)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="APK71_RS19930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_055468665.1"
                     /transl_table=11
                     /translation="MRGWLAEHIDDELLFDTPDEALSIASRLATDAEFYRVQGKHAYAS
                     TVDLAPDQVAARHLEALR"
     misc_feature    complement(20350..20365)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    20369..20383
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(20415..21008)
                     /locus_tag="APK71_RS19935"
     CDS             complement(20415..21008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000976.1"
                     /locus_tag="APK71_RS19935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_055468666.1"
                     /transl_table=11
                     /translation="MTTDTRANESQLARRITDWLEPKNWIIAVTLLAGWHTAQWTGVAW
                     GVVGALFAAVIPITFIKYGIRKGHWGDRHVGAKPARLVVMAVILLSVATGIVLMLAAGA
                     PRTMVALIVSMLVTLAILTAITFAWKISVHQAVSAGACAMLVQTYGPWMALGFLLVIVV
                     GWSRVELRDHTRNQVIAGTILGTIVAAAVFHLAR"
     gene            complement(20998..22194)
                     /locus_tag="APK71_RS19940"
     CDS             complement(20998..22194)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491148.1"
                     /locus_tag="APK71_RS19940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_055468667.1"
                     /transl_table=11
                     /translation="MSTPTLVAGVLWLVALWRVPSLRHSRKQRSLALTLVTLAAAMTFE
                     VPQVKEAVDAAAGADARLSPLLKHLLGVTSAAYLLDFVIAVVRPQGLARRTRLVAASVT
                     LPLMLAFYALANWTPGGPVRLGEGRGALFPVLYMTVFTLYIGIAMVVATWLFLGGVRHS
                     RTLLGKAGLGFLGLGTLLGSLYALQRIVFVTIQLASGTSYPALENLLSTTLKQATVLSV
                     AVGVCLPPLSVAVEYVAAWSTLRKLRPLWAQLTEAAPYVVLATSVGRWRVPFRLERCVI
                     EIEDACLALREYVSVDVHAKARRFARQEGVPEQLSEAVAEACWLRVAVHSVRNGDRLRG
                     VEYPPLGVTGRDRASELSWLRAVARAYSLPVVALFVLKETSPIPREQGASGRVSSHDN"
     gene            complement(22191..22745)
                     /locus_tag="APK71_RS19945"
     CDS             complement(22191..22745)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491146.1"
                     /locus_tag="APK71_RS19945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_055468668.1"
                     /transl_table=11
                     /translation="MFNRQFARREAQLRRLCEEQLRGIEISDPYAVDEICRQLAIKRGR
                     PLHLHELPETGGANAPCGMVLSFDHGDYVFHVAATSERHRAQIVRHELAHLLLGHAGNN
                     ESVVKSLLGLVPDGVEPSAVLSALGRTSYDSEIEYDAEMAASCLGELFHDLAHSGRERS
                     RSGAVARLDDALVHPRRNRRS"
     gene            complement(22830..23360)
                     /locus_tag="APK71_RS19950"
     CDS             complement(22830..23360)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1238: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571795.1"
                     /locus_tag="APK71_RS19950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_055468690.1"
                     /transl_table=11
                     /translation="MTPPQAKTWSQRGRTPVVRVRGRSRRRISIAALTCYKPGHRSRLI
                     YRPRRDDGNRDGRKSFSWRDYRDLLIAAHQQLDGPIVLIWDNLNVHKAADLRKFAESRD
                     WLTIYYLPPYAPDLNPVEGIWSLLRRGWLSNVAFSTPEHLARRIRRGLRHIQYRSHLID
                     GCLAETGLAIRTA"
     CDS             complement(23402..>23850)
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677105.1"
                     /locus_tag="APK71_RS19955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_055468669.1"
                     /transl_table=11
                     /translation="FREKLRLKAAKRFARGEASSAIAMDLRVSVRSVQRWRRMWDEGGP
                     RALRSQGPASLPRLSQKQFAQLEAELAKGPAAHGWEDQRWTLSRVRTVIGRRFHLTYTI
                     QGVRKLLVRNGWSCQVPARRAIERDDEAVAGWVKEVWPCAEDSRR"
     gene            complement(23402..>23852)
                     /locus_tag="APK71_RS19955"
ORIGIN
        1 ggcaccccgc aggtgatccg gatcgccgag ggcctgaccg gcgtggtgga catggtctcg
       61 gccatgcgcc ctcggccggg atacggcagc gtcagcccgt ggatccacga ggtcgagggc
      121 cgcatggtcg cggaggccgg cgcggacgca ctgtggctcg acacctgcgt cccgcaggca
      181 gagaaggacg gcgccatcgt cagtagcttc ggcatcgggg ccgggcagag cgtggcgttc
      241 gtgctcagct ggtgcccgtc ccacgccccc tcgccggacg ttcctgaccc ggagcccgcg
      301 ctcgccgaga cgctcgcctt ctggcaggac tggacgcagg agtgcaccta cgacgggccc
      361 taccgcgagg ccgtggtccg gtccttgatc gcgctgaagg cgatgacgta cgggccgagc
      421 ggcgggatcg tcgcggcgcc gaccacatcg ctgcccgagg agatcggcgg cgaccggaac
      481 tgggactacc gcttcacctg gctgcgcgac gccgccacga cgcttgccgc gctgctgggg
      541 accggttacc ggcaggaggc acaggcatgg cggcgatggc tgctgcgggc cgtggccggg
      601 gatccggaga acctgcagat catgtacggg atcaccgggg agcgtgacct gcgggagcgg
      661 gagctgccca ggcttcccgg gtacgagggc tcggccccgg tccgggtcgg aaacggcgcg
      721 gctgaccagc tgcagctgga cgtgtacggc gaggtgatcg acacactgta tctcgcgcac
      781 cagagcggtg tcgcccactg cgccgacact gcggttctgc accagcggct catcgagcac
      841 ctggtccagc gctggcagga acccgacgag ggcatctggg agatccgtgg ggcccgccgg
      901 cacttcgtcc attccaaggt gatggcctgg gtggcggtcg accgcaccat ccgcctggcc
      961 caagccggcg cactcgacgt ggacctgccg tcactggtgg agctgcgggc ggcgattcac
     1021 caggaggtct gtgacagggg cttcgatccg gtgcgcaaca cgttcaccca gtcttacgga
     1081 tcgcaggaat tggacgccgc gacgctgctg atcccccggg tgggcttcct gccgcccagt
     1141 gacccgcgag tcgtcggcac cgtggacgcg gtactccgtg agctgtccac ccccgatggg
     1201 ctcgtgcgcc ggtaccccac cgccggcgac cgcaccggga tggatggcct cacgggcgat
     1261 gagggcgcct tcctcctctg ctccttctgg ctcgtcgatg ccctggccct gaccggccgc
     1321 ctcgaccagg cccgtgcctt gttcgaacgc ctcctggctc tgcgtagcga cctcggactc
     1381 ctggcggagg agtacgaccc cgtccagcag cgccagctcg gcaacttccc gcaggcattc
     1441 agccacatgg gtctgatcca gagcgccctg ctcctccaac agacggagac gcagatttcc
     1501 cccagctacg gcgcggtcgc ggttccagca ccccgcagca cgcgtcagcc caccgcggac
     1561 ctgactccgc agcacgcata gccactccac ccccctgacg aggattccca tgcctgacag
     1621 tgccttgacg gcacggccga cccctgccga ccaccgcaga cgccggcccc cggtcgacgc
     1681 gatcatgctg cgccgagccc gccgcgccgt ggcattgccc ctggtgttcc tggccacggt
     1741 gctgggtgtc gctttcgcgc tctggccggt gtctgcagta ggtcccggct gggtcctggc
     1801 tggcctggtg tgcggactga ctggggtcac cctggtagct gctcacggag cacgcaccgt
     1861 cgccgcagcc gtgcagtcgg ccgcggagga gtcccgggca acggcactga acgcggtcac
     1921 aggggcagcg gcagccgtcg agaagtcggt tcggtggtcg gcggacgagc tgtgccgcgg
     1981 gaagcgcccg gcactgccgg atcttcaggc gtcgccgacg agcggtccga acgccgagat
     2041 cgacaacgtg ctgagtgccc tccaggcaca agcgatcgcc tcgctgaccc gcgtgcacga
     2101 cgagtcgcag tccgtcgttc tcctggaggt gctgcgccgt ctggccatgc gcgagcacgc
     2161 cctggtcggc aaggcgctcg aggctctgag ccgactggag atgctgaccg acgacccgga
     2221 actgctggcc aagatcttcg agatcgacca tctcgtgacg cggatgcgcc gccaggtcga
     2281 gagcacggcg gtgctgggcg ggcagtccct gcgcagcgtg cgccaggctg ttcccgtcac
     2341 gacggcactg cggggcgccg tctccgaagt cgtctcttac ccgcgggtgg ccgtcgcggc
     2401 cggttccgtc ggcgccgagc tgggactgcc cggccacgtg gggccggacc tgacgcacct
     2461 gctggccgag ctgatcgaga acgcctgcga gtgctcggat cccgcgacgc gggtgatggt
     2521 gcgcgcgcag cgggtgcccc acgggctggc cattgaggtc gaggaccgcg ccatccccat
     2581 gcccccgcag acgcggtcac agatgaacca cctgctcaag gccccggacg aggtcgacgt
     2641 cagcggccag gtccgggccg ggcagctcgg cctgctggtc gccgcgaaga tcgcacagtc
     2701 acacgggctg tccgtcctcc tgcaggagaa cgtgacggga ggcaccaccg ccctggtcgt
     2761 cataccggca cggctcctgg tggcgatgcc atcggtcgag gatgcgggcg cgctgcctcc
     2821 cgaggaggtc cggccctcgc agcagcccca gcaggtggcc gctgctcctg ccgcccagag
     2881 gacgggtcag gccgcacgcc ccggcgccgc tggggcgccg atcgaagcgg gccgttcggc
     2941 cgagccgccc actctgccca cgcgcactca ccggacggaa cctttccgtc caccacgcga
     3001 gcgggagcaa gcccccgtgt ccggggcaac gcctgggctc gcagccgcct tccgcaacgg
     3061 cctccaggcc ggcggcaccg ccagtccccc tcccgcctcg acagaccacc ccaccccctg
     3121 accttccttc tgcgttcccg gtggcccggt acacccactg gcccttcccc cccttctgga
     3181 gcgatcccct tgaacaccca ccccgcgatg agcaacgtga ccgacggcac gcccgcatcc
     3241 gcgacgacgc caagcggaca acgggacaac atggcgtggc tgctgcggca gttcgtcaat
     3301 gagacgcctg gtgcgctgca cgccgtcctg ctttcgcgcg acggactgcg gctgctggac
     3361 tccgacgtcg acaaggactg ggcggacgag ctgtccgccg ccttcagcgg gctggcctcc
     3421 cttgcggcga acgtcaccgg ccccagccac aagaagaggg cgccccggca ggtcatcatc
     3481 gagcgagcgg actgcctgtt cttcgtccag agcgccgggc gcagcgcggc cttcgacacc
     3541 caccccggca acgaacgcgg tgaggtggac acgatcctcg ccgtcattgc cgccgggaac
     3601 tgcgacgcgg gcgccgtcgg cttcgagatg ggccggctcg tggcgaagtt cgccccgtac
     3661 atgctgatcc ccgtccgtgt cggcacgggc ggagaggtcc ggtgaccacg tacggccgca
     3721 cggcggagga gtcggtgttc gtgcggactt acaccgtggt gcgcgggcgt accaagccgc
     3781 ggcacctgct cggcctggaa acggtgctgg aggccgggca gggaaggccc ggcccggcgc
     3841 aggccgcgga gtgcgaggag attctctctc tgtgccggga gcgccgacgg tcggtggtcg
     3901 agctggcggg ccgccttggc cggcccgtca ccgctgtcaa agtgctcgtc tccgacctcc
     3961 tggacgccga cgccctcgtc gtccccttga cccagtccta tgcagggtcc ggtccgtcta
     4021 cccaactact ggcagccgtt tccgccggct tgaagaggaa gtggcctgat gccgtcacct
     4081 atccccaggc cggatgaccc ggccgtggtg ccgcgtactg cgcagcaccc gcccgccggc
     4141 gccgctccga ctgtgctgaa gatcgtgatc gccggcggct tcggcgcggg gaagaccacc
     4201 gccgtgggcg ccgtcagcga gatcacgccg ctgagcacgg aggagtacct gaccgaggcg
     4261 agcgcagacg tggacaacct ggcgggcatc gaagcgaagc agaccaccac ggtcgccttc
     4321 gacttcggcc ggctgagcct gcccgacgca ccgatacctc tggagctgtt cctgttcggc
     4381 acgccgggcc aggaccggtt cgtcgacctc tggtacgacc tctcccgcgg agccatcggc
     4441 gcggtcgtcc tggtcgacac ccgccgtctg gaaagcagtt tcgcccccgt cagcttcttc
     4501 gaagacatcg gcctgccctt cgtcgtcgcc gtcaacgaat tcgacggagc acaccgctac
     4561 caccccgagc aggtccgcac cgccctcaaa ctcccctccg ccgtccccgt ggtcacctgc
     4621 gacgcccgcg acacgaacca cgtcgccggc gttctgctgg ccctcgtcga ccacgccgta
     4681 aacaacgcca ccagcagccg cgctggtcac acctctacca ccctccagga cgcctgatgt
     4741 cacagcaccc cagcgacccc taccgcacgc cgcagaccac ccagcccgcc cggtccttgc
     4801 cgcggcgcga cattcgggac accaaccgcg gaccgttcac ccctcccgcc accaccctca
     4861 ccagccagcg gcctcagcag tcgctggagc ttgcgcagcg ctacgagctg ctcaaccgct
     4921 tgggcgtgtc gcctgtggcc aacgaggact tcgacgacct ggcccgcgac atggccacac
     4981 aggccgggtt tctttacggg ttcgtcaacc tgttcctgga ggagcagacc tttgtcggac
     5041 tgcaccagcc gccggcggac agcgggttcg tgatcgtcgg gcgcaccatg agccgggatc
     5101 acggatggtg cccggaggtc atggcacgca agaaggccct ccctctgcac gacgtgcacg
     5161 cgtccccgcg cttcagcggc aacgcggtgg tcgacgccgt cgggatccgt tcctacttcg
     5221 gcgcaccgct gatgcacgac agcggcacgg tgctgggaac ggtgtgcgtc atcgaccccg
     5281 agaagcggcc cctggcggag gcccgccgtc tgcgggacat cgtcatcaac gccagcgcgc
     5341 aggtgatgga ccacatcgcc cgcgcccccg tccgctaggc cgttccacca ccccccaccc
     5401 gggagccgta ggcgatcccc ggccgctccg cgttgcgacc ttcatccagg gagagggaaa
     5461 accatgtccg ccacacccac cacaccgcca ccggcgctgc atccctacct caccgcgcgc
     5521 catgacctgc tgtggcagga ggcggacgcc ttcgcggccg agcacgtcgt gccgcgtgcc
     5581 acgcggatgg aggctgctcc gggcagggtg gagcgcaagg tcgccagcct gatggccgcg
     5641 aagcagtggt tcgccgtcac cgtcccggcc gccttcggcg ggctgggcgc cggacacgta
     5701 gccaagacca tcctcgtcca ccgcatcgcg cgggtctcgg cggctgccgc ggccatcctc
     5761 caggccaccc tcatccccgt cggcgccctg ctgcacttcg ccacctatga gcagaagggc
     5821 cgctggctgc cccaggtcgc ggacggttcc ctgctgctgt cgatcgccgt gaccgaaccg
     5881 ctcgccggcg gacacatcgg cggcatcgag accaccgcgg aacgcgtcgg caacgagtgg
     5941 gtgattaccg gcagcaagat ccacatcggc aacagtcacc tcgccggtgt ccacctcgtc
     6001 gtcgcccgca ccgccgcacc cggggtgagt acctcacagg cgctgaccgc gttcatggtc
     6061 gaagccgacc gccccggact gtccgtcccc gaccatcgtc ccggcctcgg cctgcacggc
     6121 ttctccgccg gccgcctcga ccttgaccac gtccgcgtcc ccgacgacaa cgtggtcggc
     6181 gaagtcggcc agggactggc cgtggcccag agcagcagca tcctctacgg ccgccccaat
     6241 ctggccgctg tcagcctcgg catccacgaa gcagtcgtgg acaccaccac cagcaggctc
     6301 aagacccgtc cccgctaccg gggcgccctg tccgacctgc ccgtcctccg ggaccgcatc
     6361 ggcggcatgg aagcccgcct gcgcgccggc cggatactcg cgtaccagtc cgtgcacctc
     6421 ctcgaccggg gcctgccctg cgacaccgac ctgatcaact cgaaatatct cggccaccag
     6481 tgggccatac actccgccca ggacgccatg gaactgcacg gcgcccacgc cctcgacggc
     6541 gactacgtcc tccagcgcct gtggcgcgac atccagcaca cctacccacc cgccggcacc
     6601 ggcgaagtcc agcgcatacg cctggcagac gctgccttcg acgaggacca catccagtgg
     6661 tcggaacacc tcgccgccga agccgcctgg gcacgacccg acccgaccgc cgcataagcc
     6721 cccgtgcgcg gcaccccgtg actccccatc gccgcgcacg ggcccgtgcc gccggccccc
     6781 gtcccccgcg gggaccggcg gcacccctcc cagtgaccat ccacccagcc gagagagaca
     6841 ccgtgacccc gcccgtgacg accaaagcac cgatcacacc cctgacgccg accctgcagc
     6901 gcgtcgccca gcacctcgcg aacggcctca cggcccaaga gatcgccacg cagaccggcc
     6961 tgtcacccgt gaccgtccgc cagtacctcc gcgacatccg cgagagcctg cactgcccgc
     7021 cccgctgcaa gcccccggtg atcgtgcacc gcctgttcac cacccagcag gtggcctcgc
     7081 ccacggcgga caggccggca ccgacgctca gcccggttca gcggctgctg ctccgagccg
     7141 tcgccgagca cagcgacccc cgtgacatcg ccatcgccgc caagctcgcc cccgccgacc
     7201 agcgcgccgc actcgaccaa ctcctcgccg acacgggtgc gcgggacact gcccacctgg
     7261 tgatccttgc ccacggctgg aagctgctgc cgaccgacgc ggcggcgcgg agcggagcgt
     7321 gccagtgaga aggcccccca ctcccctggc caatgagcag cctccgactg ctacctcgtt
     7381 cgcgtcaaag tacgcgggcg ccgtatacgc ggtgcgcacg ttacgtacgg acgccgagcg
     7441 cacggaagcc gctgccctcg tgcaggaccg gcagcgatgg ctcaccctgc gcggcctccc
     7501 cgtgcccgcc caagccgacg ttccggccct cttccgcgac ccgcacacga actcggccgg
     7561 tctgttcgag gacggaaagc tgctcgcctg catggtcccc gcgcgcgacc ccggactcag
     7621 ctggggcgaa ggcccctgcc tccgcctggg acgcgtccac accctgcccg accagcccga
     7681 cgacatcacc cgactgatca ccctgtgggc ctccgacctc gccgcccggc agagcctccc
     7741 gctcgtacgg gccgaaatcc tggcccgcca cgccctccaa accgagccca tcgccgccct
     7801 gctgcgccgg ctcaccgaca tgggctgggg acgtgcgggg ttccggcccg ggacgggagg
     7861 gggaccgcgt cgcccgcctc gaactggccg ccgagcaccg ccccagcctc agcacactga
     7921 tcagctgcca gacccatgcg cctcatctgg ccgcggacga tcggagcacc gagtgacaac
     7981 cgacgaaccg cagcgactcg accttgcccg cgagctgatc gcccgcgcaa acgaatcggc
     8041 cgtgcaccga gccaaacgcg tgcgcaacca gctcgacgcc gtccaactcg ggcagggccg
     8101 gcacaccgac cacgccaaca ccaagttcct gcgccgcgtc ctgggcgaat acgagtggcc
     8161 cggccaccgc ctcgtcggcc ctgctgccgc ccgcgccgcc tggagcatcg ccctgcacag
     8221 cgaccacgat ctcaccctcc agcgcgccgc caccatcctg ctcaggcgtg cggtccaggt
     8281 cggcgacgcg ctcgtccagc actgggcgca cctgcacgac cgcgccctca tcaccagcgg
     8341 acgcgcacag gaatacggca cccagctcct gctgaccgcc gacggcatcg gactgtgccc
     8401 gctgcgcgcg ccggcgtccg tcgacaaacg cagggcgacc gtgggtctgc cgccgctggc
     8461 cgtcgctctc aaagcggtgc gccgccgcta tacgccggac agctccgccg acgaagcccc
     8521 gaccgtcgtc ctcgcgggga tcgccgcctg aaccagcgga accccggtcc accaccagcc
     8581 agcacaaatg ccacaaatgt gaccctgaaa ggatcgttga ccgatgaagc tcaccaccgc
     8641 cgtcctcgct gccggtgctg ccgtctccct caccaccgct gtggtcggag ccacccggct
     8701 caggcaggag gcgcggcacc agaccgagcg caacgaggtg ttcctcaccc gcaaccagct
     8761 cgactggctg gcccagatgt ccaccaaccc cgatctggcc aagctctggg ctccggagga
     8821 catggacgtc gaggagtaca tgcagctgct cgcggccaac cggctcatct gcatcctcag
     8881 cgtccgcgac cgcctcggct tcgtccgctc cggacacctg ccctggtacg ccgcgaagct
     8941 gatggagagc gacgtctgcc ggcgctactg gcagcggttc ggcggcctcc gcgctgagga
     9001 ggccgagggc gatgagcagg gcgagcactt cacccgggtg ctggaccggg ccgcgaagaa
     9061 ctacccgtcg gcgcagcccg tagcagcatg aaggcgtagc tcggtcccgt cacctttcgg
     9121 acttcgtgtc cgcccccaac tcctctgccg gacagcagat tccgtgtctg gagaggtggc
     9181 cgaggagggc ccgaccggcg cagtcgcaca gctgccgtcc accgggcaga gccggccgca
     9241 cagcaacaca ccgaatcgac gagttccacc acaccgatca ggaggatccc cgtgacttcc
     9301 agggtgacca ccagcgagcg agggccgcct cagcctctgc cgcgcaggac ccgttcgacc
     9361 tcgacatcag cgtcatcgag tcgggcggca cggtcggggc gagtatcgcc tccgacggcg
     9421 gctgcggctc gacctgcggc ggcaatgcct gcatttccag cggctcctga ccgcaccaga
     9481 ccaccggcac gacgcccatg tcgtgccggt gccgcccaag cggcacggcc cccgcggctc
     9541 gaccggagcc gcgcacgact acggaggaag caacacatgg agcacgacga gttcgacctc
     9601 gacatcaccg tcctggagtc cggcgacgga caggccgtac tgatcaacct caccgacgac
     9661 ggctgcggca gcacctgctc cagcccgtgc gccaccaacg tggcctgagc atcttccacg
     9721 acgagtaggg agagacctgc atgaaggcga acacgatcaa gggccagatg cagtccccgg
     9781 ccgccacggc gggcggtgac gcgttcgacc tggacatcag cgtcctggag tccggtgacg
     9841 gctccgccac ggtgatcaac ctgacggacg acggctgcaa gccgagctgc aacgggtcct
     9901 gcgccaccaa cgtggcctga cccgagcgcg cgatcgccag cccgcgcgac catccgtcgc
     9961 gcgggctggc acctcaacac gccacaacca gggagggtgc atggattccc ggaaggacgg
    10021 cccgctgtac cggtgcgcgg acgctgcgct ggtgcgcgcc gcccgttact cacggttgcc
    10081 gcttcccgcg tggccggacc tcaccgacga aacccccggc cgtcaggtgc ggtggcaggc
    10141 gtggctgcgc gacatctggg cgctgcacga ggccgccgac tccatcgagc aggccagccc
    10201 tctgctcgcg cagcaggttg caacgctgtg ctcggcggcc agccccgaga cccgtcagct
    10261 ccgacgcgct ctggtgtcgg tcatgcggta cctgctgcgg atgacaggcc gagcgacccc
    10321 gaatggcctg ttcgccggca tcgcgcccgc ctcgttcggg gaacggccgg agtggtcctg
    10381 gggcgagtgg caccgtcctg tcgtccgcgc tgatggcgac tggatcgcag acctgatcgc
    10441 ccgcctggaa gcaaaccccg aactcttacg gcacctgcgt gtgatagcca acaacaccat
    10501 cttcgtacgg ggtgatcggc tgatcgtgcc ctacccgccc cgctcacgcc gcaccgagga
    10561 cagcccggcg gccgaggtat ccctccggta caccggcgcc gtacgtatcg ccgtcgtcgc
    10621 cgccgcctcg cccgtccccg tccatgtggt ggtcgaactg atgagggccg agttccccga
    10681 cgttccggct ggccaggtgg aagggctggt cagcagcctg gtcgagcgcg gcgtgctcat
    10741 cagtggcctg cacgcgtcct cggcctctct ggacgccctg gaccacttgg tccagcaggt
    10801 ggaagccgcc gacgcgccgt cggccgcgga cctcgtggcc gacctgcggg cggtccgcga
    10861 cgccatcgcg cagcacaacc aggtcctcgc ccccacggac ggtcggcgcc tgcgtaccgc
    10921 cttacgtcag aagatgaccg ccttgagcac cgtcaagacc cagccgctca cgctggacct
    10981 gcgcatggac tgctccctca ctctgccccg gcaggttgcc cgcgaggcag agcaggccgc
    11041 cacggtgctg gcccggctga ctgcgtaccc cttcggtact ccggcgtgga aggacttcca
    11101 caaccggttc ttcgagcggt acggcatcaa cgcgctcgtc ccggtccggg acctggtgga
    11161 cccggacgtc ggcctcgggt tcccggctgg ataccgcgac gcggaacctg aaaagcgtga
    11221 ggccctgacc gcccgtgaac agcaattgtt cgctctcgcc caggcggccg tcctcgacgg
    11281 ccgcgacgag atcagcctgg acgaggacct gatccgcacg ttgacggtcg gagaccgaca
    11341 cgccccacag gtaccggccc acactgagct gcgcttccac atccgtgcca cttcgcaaga
    11401 ggcactggag agtggagact tcgtcatcca cggcatcgcc ccttcccgcg gaatcggcac
    11461 cacgatcggc cgaagcctcg gactgctcgc accagacgat caggcccgcg taggcgcctt
    11521 gttgaaagag ctgccggtca acatgcccgg ctcgatcccc acgcaagtct ccttcgcccc
    11581 actcaaccgg ggaggcacca acgtcacccg cgttgccgaa gtcctgccga ccgtcatcag
    11641 cctggcggaa catcgtcagg tggacgagcg cacgatcacg ctcgacgacc tcgctgtggg
    11701 ctgcgaccgg cgcaggctct acctcgtctc cctctcccgg gcgtgcctac tggatcccat
    11761 gacgctgcac gcgctggacc tgcgaggcca cacgccgccg ctcgcgcgct tcctcaccga
    11821 gatcagccga tcccagaccg ctgtcctgac tgtcttccct tgggcgtccg ccactgccct
    11881 gccgtacttg ccgcgcgtgc gccacggccg cgcgatcctc tctccggctc ggtggcgact
    11941 ggagcggtcg gaactgcccg accgccgcgc ctcctgggag gagtggcaca aggcggccga
    12001 cgggtggcgc gcacgccgcc gagttcctga ccacgtcacg ctggccgagg gcgaccagct
    12061 tctgccgctg gacctctccg aacgtgcgca cctcgcgctg ctgcgcaccc acctggacac
    12121 ccacgaatcg gcgatcttga cggaagcgga gtccgacgga ggctggttcg acggacggtc
    12181 ccacgagatc atcgccccaa tgacggccgt ccgcccgccg cagtggccgg ccgtcccgcc
    12241 catcaccacc gaccagctca tcacccgcga ccacgggcac ctcccgggcg ccgcctcctg
    12301 gctgctggtc aagctgtacg ggcacgtcga acgacagccc gaaatccttg ccgaccacct
    12361 tcccgcgctg ttcgagcagt gggacgcgcc gcctacctgg tggtacatgc gctaccggga
    12421 cccccgctgg cacctgcgcc tgcgcatctc ggtccccagt gagcaggact tcgccctcac
    12481 ggcggagcgc gtgagtgcct gggcgaacgg actgcgccgt gccgggatcc tcgccgacat
    12541 gcagttcgcg acctcctacc cggagaccgg tcggtggggc acggggccgc tgatgaggct
    12601 ggccgaggac gtgttcgccg ccgactcccg agccctggcc gtccagttct cccagagcac
    12661 ccgcccgcac cgacaggtcc tcgccgccgc caacttcgtg tccctcgccg ccgccttcac
    12721 gggcagcatc gcggccggca tggactggct gatcgcccac ggccggatca ccgacccgcg
    12781 cccgacggac cgggccatgc gcggtcaggc ggtgcgcctg gccgatccga ctgacggctg
    12841 ggcggccctg cgcgcggccc ccggcggcgc ggccatcgcc agcgcctgga gcgagcgcga
    12901 cgaggccctg gcccgctacc ggcggaagct ggacacctcc ggtggtggca tagacccgga
    12961 cctcgttctc gactcgttgc tgcacgccca ccacatccgc gccgtcggca tcgacaagga
    13021 cgacgagcgg atgtgcgtac ggctggccca cgccgccgcg atggcctgga ctcaccgagg
    13081 agatcaccat gaacctgcgt gacagcgcgc gggtcactgc cgacacgatc gccgagcggc
    13141 tcgcctcgcc ggaggacgta cgggggctgc atcaccgcca gggttggtgg ccgcagtcgc
    13201 ttgcgcacgg tgcggtcggt gtcgcgctgc tgcacatcga gcgggcccgc accggtcaag
    13261 ggccgtggca gcgcgcccac gactggctcg cctgtgccgc agccgaaccc gccgtcggcg
    13321 gcccggacag ccacctctat tacggggcgc cggcgctcgc cttcgctctc cacgccgcct
    13381 ccgaccgtcc cggacgctac gcccgcgccc tggacaccct cgaccggtat gtcacgacgg
    13441 cgatccggga ccggctcgcg gacgcccacg cgcgcatgga ccgcggcgag atgcccgcgc
    13501 tggccgagtt cgacgcgatc cgcggcctga gcgggatggg cgggctcctg ctgcaccgcg
    13561 acgtccacac cgacgtcctc cgcgagatcc tgacctacct ggtccggctg gccgagccgg
    13621 tcaagcacga cggggaagtt ttgcccggct ggtggagcca cctcgccccc tccgggacga
    13681 tctcccccca gtatccggag gggcacgcca acaacggcgt cgcccacggc atcgggggcc
    13741 ccctcgcagt gctctccctc gcggcccgcc gcggcatcac tgtcgacggc caactcgacg
    13801 cgattacgcg catcctggcc tggctcgacc actggctgca ggacggtccc gccggcccgt
    13861 ggtggccgta ctggatcacc cgcgaggagc tgcgctccgg cacgaccggc cccggtccct
    13921 cccggccgtc ctggtgctac gggaccgcag gattcgcccg cacccagcag ctcgccgccc
    13981 tcgcccgaga ggaccccgcc cgccaacacg ctgccgaatt cgccctcctg cgcgccatga
    14041 ccgacccggg ccaactcgac gcgacggtgg atgtctccct gtgccacggc ttcgcgggcc
    14101 tggcacgcat cacgcaactc gctgccgccg acgccctcac ccccgggctc gccgaatgcc
    14161 tgccccggct cctggccccg atcaccgaca ccgcgcccgg caccctggcg gactccctgt
    14221 tcgccccgcc cggcggcggc gacatcggac tcctcgaagg tgccgcaggc accgccctcg
    14281 ccctgcacgc cttccacacc gggatgccgt ccgcgtccgg gtgggacagc tgcttcttga
    14341 tcaactagcc gacgagaaga gggaacatgg cagcggacga atggccgcaa cgcctcatcc
    14401 ggttcaccga ctggagccgc gcggaggcca ccgccgtgga gcatctgctc ccggtgctga
    14461 tcgcccagga ggcggaactg gcccagtggt cgttcctgcg gaagtacccc tggtggcggt
    14521 ttcggtaccg ggccgcgggc ccggactcgg cgaaggccct ggacgctgcc ctggacgaac
    14581 tggtcgacgc cagcgtcctc gcttcctgga ggcggggcat ctacgagccg gaagagacgg
    14641 ctttcggcgg ccccgccgcg atgaagatcg cgcacaccct gttccactac gacagccgtc
    14701 acctgctgga ggaggcggct cgccagcagg cagtcagcgg cccccagctc ggtcgccgcg
    14761 agctggcggt cctcctgctc agcgtggcga tgcgcgcggc gggactcgac tggtacgagc
    14821 agggcgacgt ctgggcgaag atcgtggccg aacgcccccg tgacgaggtc cacagcccgc
    14881 aacggcaccg ggctgctgtc caccggttga tgaccgtcga tgtcagcacc accagccgca
    14941 gcgtcaccca gggccgactc gcgccgctgg ccgagtggat agccacgttc gagtggttcg
    15001 gccagcagct cgccgacctc aaccgtcagg gccgcctgga acgagggctg cgggccgtga
    15061 tcgcccacca cggcatcttc cacttcaacc gcctgggcct ccccgcccag gaccagcacg
    15121 ccttgtcaac actcgcgaaa gaggcagtca tgggaacgag cgacaacgcc gcgtccaccc
    15181 gaaccgaggg gacgccgagc actacggtca acggggtgaa cagtgacact gtcgaagccc
    15241 cgtccgccga ccgtctgcgc gcccagttga tcgaccacct ggtcgagacg ggatgcgtgc
    15301 gcacgtcccg ggtggaggag gccatgcgga ccgtaccccg ccacctcttc gtcccgaacg
    15361 ccccgctggt gaaggcgtac agcaacgccc ccgtggacac gaagttcgac gggtccgggc
    15421 gctccatcag ttgcgcctcc cagcccgaca tcgtcgccat gatgctggaa cagctcgacg
    15481 tccagcccgg ccagaaggtc ctggagctgg gggccggcac cggcttcaac gccggactcc
    15541 tcggctacct cgtcggcgag acgggacacg tcaccacgat tgacgtggac gatgacatcg
    15601 tggccggagc gcgcggcggc ctggccgccg ccggcatcca caacgtggaa gtgatcctca
    15661 aagacggagc agtcggccac tcccccaacg cgccgtacga ccggatcgaa gccaccgtcg
    15721 gcgcccacgg cgttccgcac gcctggctcg accagctcgc ccccggcggg cggctcctca
    15781 cgccactacg cctgcgcggc agcgtctccc gctcgatcgc cttcgagaac cagggcggtg
    15841 cctggcgcag cgtcggcagc cagatgaaca cgttcatgcc gctgcgccgg ggcatcgccg
    15901 acgacccgcg cgtctttgtt cccctggacc ccgaccacac cgtcacgctc gtcaccaacg
    15961 gagaccagca ggtcgacgcg gacgccctga gtgacatctt ccgccagccg tgcaccgagg
    16021 tgtggacgga cgtcaccttc cggggcccgg agtcggcgga gtacctggag ctgtggctcg
    16081 cctgcgccat gccgaacggc ctgagccgga tgcccgccaa gggcgaggcc atcgagaagg
    16141 gtttggtcac cgcgccctac ccgtcctcga ccgcggtctt cgagggtggc acgctcacct
    16201 acctcacccg gcgcccgtac gcgaagaagg cccccgacgg cgccaccctg tacgagttcg
    16261 gcgtcatcgg ccacggcccc gacgcccaag ccctcgcctc ggacgtcgcg gaccagctcc
    16321 gcacctggaa ccagagcttc cgggcgctcg acgtcgggtt cgagatccag ccgctcgacg
    16381 cgaccccgct cgcgccgaag cccggccgct tcaccttcga caacccgctg aatcgcatcg
    16441 tcatcgaatg gcagtgacat ggacgtcagc cagatagcga agcggttccc gctcgttgcc
    16501 cggccacgtc cagcgtgccc gcccctcgct gaacgcatcc gcgagatcac cgacctcgct
    16561 gccgccgccg agcgcgatga caacgtgacc tccgcaaccg tcgccctgaa caaggcggca
    16621 ctgatcgcga gcgactgcgg catgccgaac ctggcacgcg ctctgtgctg gcgccacgcc
    16681 gaggccgtcc tgcgcgccca gcccctgggc gcgcaggaag cccggcacgc cctggaaccc
    16741 ctggtcaacc tggcccgact acgcatccgc gacggcgacg ggcccggcgc gtaccacctg
    16801 ctcgactcct taacccgagc ggtgagatcg cagagtgaaa cggtcatcga cggccacacc
    16861 acatccttcc agcacctcac gacgtcggca ggcgaccatc aacaggtgtg ccagtggctg
    16921 tggaccgtcc tccttggcga tggaacccgt gcccttgtcg cagcaggtga atgggatcgc
    16981 gcactaacac acagcaagca gcaccggggc ataggccaac gcctcctcga cgggcgtcaa
    17041 gtggaagtac tcgtccgctg tcttggcgag caacccagta atgcgctgaa gttcctgcac
    17101 gaaagcaccc tggcggagcc atgggagcac tccgtctcgg cagccctcac cgtcctctgc
    17161 cacagggcag cagacgagca accggttgag ctgatcgcca agatggtgca gcgctatttg
    17221 gctctcggct cagcccccga acttgccgtg ttccggtccc gtgtgggact ggtcgtgctc
    17281 gacctctccc caaggagccg acggtccgaa gcaatgcacc gcctcgccag cgaagcgacg
    17341 gcgcgtcccg acgggtacat cgcacgagac gttctggccc acccggtggg ccgcgaaggg
    17401 ctgagccagg acgagcgcag aacactcgcc gccgccgtca cctccgccgg cctcgggctg
    17461 ggcaccatcc ccgcccctct ggcgcaggcc atgcgggacg cttcgacagt cgcagtgggt
    17521 gtctgggaac gccacgccaa ccgccaagca aacgccccat cggcgtcctc aaggccggac
    17581 cggaagccgg caccctgtcc gcccacggcc acgaggccct gaccggcacg gttggccacg
    17641 ccgagagaga actggaaggg ctcctggagc cgacccggga ccggctaggg ggatgacccg
    17701 taatgcccgg acctccacgc gatgacgggc aggcttccca tcacgactga atgaggtgtg
    17761 ttccatatag ccgtcgtgtc gtcagatctc aacactcagc cgcagcgacc gtctttgggg
    17821 gggggccgat ggcctcggcc attgcgcggg accagccgcc gcagccaaac aaggggccac
    17881 gccggacgac aaaccgcccc gacggcagcc acgccacagg agcgcggcca ccacaccctg
    17941 gcccggttac gacggccaga cccgcaacag acgcaaagcg ttgaacggag gcacgcatgc
    18001 ctgatgacat ccaacaggcg atcccggcca tcccgcgccc gacgggcggc aacggcccgc
    18061 aagagcacca catgcacctg ctcggacggt actaccgcca agtggaggca ggccgcaaga
    18121 cgatcgaggt cagggtggcc accccgaaca agcggaccat cgccgccggc gacacggtcg
    18181 tcttccacga ccgggacacc ggccgggaac tcgacgtcac cgtgcagcgg atcacctcgt
    18241 acccctcctt cgaggacctg ctcagctcgg aggatcccgc acacatcgac ccggacgagc
    18301 cccccgggga gctgctcgcc gccctccgca gcatctaccc gcccgtcaaa gaagcgctcg
    18361 gtgtgctcgc cttcacgttc gaccaccgcc ctgcccggcc agggcgcccc atgccgatga
    18421 cggccgagga atacgcgcag accgtccccc accacacggt gtacggctgc ctgtacatcc
    18481 gcgacgagca cgaccggccc atccagctcc gctcggtcta cggctcgaga ctctggcagt
    18541 tcccgggcgg caatctggac gccctgggcg aggacccgct gcagaccgcc cggcgcgaag
    18601 cggtcgagga gacgggcctc gaactgggcc tgggcacgcc gccgctgctc ctgacgcact
    18661 tcctgcacgc cgggccccgc ctgccgctga acaaggtggg gttcgccttc gacggaggcc
    18721 ggcagagcgc ggaccagctc gaccggatcc gcctcgcccc agctgagcac gacatgtggg
    18781 ccgtccacga cctcgccacc tggcaggagc tgatggcgcc gcgggccttc gcccgcctcg
    18841 acgccgtcga gcaagcacgc cgcggcgagg gccccgccta cctcgtcacc cgcacctgac
    18901 ccagcatgcc cgccagggag acgccctgcc cgtcggacga gcggtaactg accgttcaca
    18961 gcaccttatg gaggtagaca gtgagcacgc aggaccgcgt ccggctcatg ctgtggaatc
    19021 tgcagcgtga cggaggcccg gagccccgac ccggcgtcct gccggaacgg tggcggcagg
    19081 gctacgagga ggttttgaag ccacagcggc cagattggct ggccatgctg gaactcaagt
    19141 attcacagac ccggccagac gtggcaccgg cggagaagca cgcggcggag cgccgtttca
    19201 cggccgcgca gcagatcctc ggtatgcgcg gcttccgtgc cgcggttggg cagcgcacca
    19261 atcccaccgg tgtgttcata cgcgaggccg tctttccctc tgcccgccag cgtcaccacc
    19321 ccgtcggcca cagtgcaccg cccacccacg tcgaactgcg gctcgccgag gccccggacg
    19381 tgcccgtcat caccgcctct ttccacagcg ccttctgcaa cccggcacaa cgccgctccg
    19441 aagccatgga cttgaccgaa ctcgtcgaca aggtgaaggc ccaccatccg aaccctgcgg
    19501 ggggtcacgc cgcctgctgg ctgttcggcg acaccaacga gtacccggta cccatcggcg
    19561 agcaggtccc tgccatcgac tggtcttccc cggaggtgac cgacatcgtg caccgtcggc
    19621 accgcgcgat caaacagccc gacggcacct gggccagctg taccgcggtg gacgagatca
    19681 tgctggactg cggcatgcac gaccccgccc gctgggccgc gcaccgcctg ggccagacca
    19741 ccgcccttgc cgcgacggcc gggtatgccg ctgtcggtca gggcggcccg cggcggatcg
    19801 accgcggcta tctggacgcc tggagcgtgc aggccgtcga aaacgtccgc gttctggaca
    19861 ccactgggct cagcgatcac cacgcggtca tcgtcgacct ctcccgtcgc aagctgatcg
    19921 agggcttgca tcgccgcacg agcgccatag ctccctggtc cttggtcgtc tgaagagtcc
    19981 tggtcacgcg cacctcaccc cgccctcctt gctcaggagg caaccgtgcc cgccgaggag
    20041 gaactgctcg ctgtcggtga cctcggcggc cagccggtag gcgcggcgca tgccccgtac
    20101 cccgtgcagc cgcttcactc tggtgcccag gacacgctgc acacgtgcgt gcagccggtc
    20161 cgcgatcggt tcgtcgtacg acagcatcac cgcgtcgaag tcgctcatcg cagggcctcc
    20221 aggtgccggg cggcgacctg gtcgggcgcc aggtcgacgg tcgaggcgta ggcgtgcttg
    20281 ccctgcaccc ggtagaactc ggcgtcggtg gccagccggc tcgcgatcga cagggcctcg
    20341 tcaggggtgt cgaacagcag ctcgtcgtcg atgtgctcgg ccagccatcc cctcaaccat
    20401 gcccctccct cggatcagcg tgccaggtgg aagacggctg cggccacgat ggtgccgagg
    20461 atggtgcctg cgatcacttg gttgcgtgtg tggtcacgca gttcgacgcg ggaccagccg
    20521 acgacgatga ccaagaggaa gccgagggcc atccacgggc cgtaggtctg tacgagcatc
    20581 gcgcaggcac ctgcggacac ggcctggtgg acggagatct tccaggcgaa ggtgatcgcg
    20641 gtgaggatcg cgagcgtcac gagcatcgag acgatgaggg caaccatggt gcgcggcgcc
    20701 cccgcggcga gcatcaggac gatgccggtg gctactgaga gcaggatgac ggccatcacg
    20761 actagccgtg ctggcttcgc tccgacgtgt ctgtcgcccc agtgtccttt gcgaatgccg
    20821 tacttgatga aggtgatcgg gatgacggcc gcgaagaggg cgccgaccac gccccaggcg
    20881 acacctgtcc attgtgcggt gtgccagccg gccagcagcg tgacagcgat gatccagttc
    20941 ttcggctcaa gccagtctgt gatgcggcga gccagctgtg actcgttggc gcgggtatca
    21001 gttgtcatgt gaggagaccc ttcccgaagc accctgctca cggggaatgg gcgacgtttc
    21061 tttcaggacg aatagggcaa cgactggcaa ggagtacgcg cgagcaacag cacgcaacca
    21121 cgatagttca ctcgctcgat ctctcccagt gactccgagc ggaggatatt caactccccg
    21181 caaacggtct ccatttcgga cactatggac ggctacacgc aaccagcatg cttccgccac
    21241 tgcctcagag agttgctcag ggaccccttc ttgccgggcg aacctccgag cctttgcgtg
    21301 cacgtcgact gacacgtact cgcgaagcgc caggcaggca tcctcgatct cgatgacgca
    21361 ccgctccagc cggaagggga cacgccacct gcctacagat gtcgccagca ccacatacgg
    21421 ggctgcttcc gtgagctgtg cccagagggg gcgcagcttc cgcagggtgc tccacgccgc
    21481 gacgtattcc acggcgacgg agagaggagg caagcagacg ccgactgcga ccgacaggac
    21541 ggtggcctgc ttgagcgttg tggagagaag gttctccaag gctggatagc tagtgccgga
    21601 ggcgagctga atcgtcacga agacgatgcg ctggagggcg tacaggcttc cgagcagggt
    21661 tcccaagcca agaaatccga ggccggcctt ccccaggaga gtccggctgt gtcgtacgcc
    21721 gccgaggaac agccaggtcg ctacgaccat ggcgatgccg atgtacagcg tgaagaccgt
    21781 catgtagagg acagggaaga gggcgccacg gccctctccg agcctgacag gccctcctgg
    21841 cgtccagtta gccagggcgt agaaggcgag catgagaggc aacgtcacgc tggcggccac
    21901 cagccgggtg cgacgcgcca ggccctgcgg tcgaacgact gcgatgacga agtcgagcag
    21961 gtatgccgcc gaggtaacgc cgagcaggtg cttcagcagc ggcgacagcc gggcgtctgc
    22021 accggcggcg gcatcgactg cctctttaac ctgcggaact tcgaacgtca tggcagcggc
    22081 gagtgtcacc agggtcagcg ccaggcttcg ctgcttgcga gagtgccgga gggacggcac
    22141 tcgccataga gccaccagcc agaggacgcc ggcgacgagg gtgggtgtgc tcatgagcgg
    22201 cggttcctcc gtgggtggac cagggcgtcg tcgagccgcg ccactgcgcc ggaccggctg
    22261 cgttcccggc ctgagtgggc aagatcgtgg aagagctctc ccaggcagga ggcggccatc
    22321 tcggcgtcgt actcgatctc gctgtcgtag ctcgtacgcc cgagagcgga gagcacggca
    22381 gagggctcga ccccgtctgg gacgagtccc agtagagact tgacgacgct ctcgttgttc
    22441 ccggcgtgcc cgagcagcag gtgcgctagt tcgtggcgca cgatttgcgc gcgatgacgt
    22501 tcgctggtag ccgcgacgtg aaagacgtaa tccccgtggt cgaacgaaag aaccattcca
    22561 cagggagcgt tggcccctcc ggtctcaggc aattcgtgga ggtgcagggg gcggccacgc
    22621 ttgatggcga gctgccgaca tatttcatcc accgcgtagg gatcggatat ctcgatcccc
    22681 cgcaactgct cctcacacag tcgcctcagc tgcgcctctc tgcgcgcgaa ttgccgatta
    22741 aacatggacg agatccttgc tgtagccccc gaatgagcgc tgacacggcc tgcactactg
    22801 aggttgaact cgtgatgtcg tggggttgct caggcggtcc tgatggccag gccagtctcg
    22861 gcgaggcagc cgtcgatgag gtgactgcgg tactggatgt gccgtaggcc gcgtcggatg
    22921 cgccgggcga ggtgttcggg ggtggagaag gcgacgttgg agagccagcc gcgtcgcagg
    22981 agggaccaga ttccttcgac ggggttgagg tcgggtgcgt agggcggcaa gtagtagatg
    23041 gtcagccagt cccgtgattc ggcgaacttc ctcaggtcgg cggccttgtg gacgttgagg
    23101 ttgtcccaga tgagcacgat cgggccgtcg agctgctgat gggcggcgat cagaaggtcc
    23161 cggtagtcgc gccaggagaa gctcttacgt ccgtcgcggt tgccgtcgtc ccggcgcggc
    23221 cggtagatca gtcttgagcg gtgaccaggt ttgtagcagg tcagcgccgc gatggatatc
    23281 cgtctacggg agcggccgcg gacccgcacc accggagttc gaccgcgctg tgaccaggtc
    23341 ttcgcctgcg gcggtgtcat ggagaatccg gcttcgtcct cgaagacgag ccaggctcca
    23401 ctcaccgccg cgagtcttcc gcgcagggcc acacctcctt gacccacccg gccaccgcct
    23461 cgtcgtcccg ctcgatcgcc cgtcgggccg gaacctggca ggaccagccg ttgcgcacca
    23521 gcagtttccg cacgccctgg atcgtgtagg tcaggtggaa gcgccggccg atcaccgtcc
    23581 tcacacggct cagggtccac cgttggtctt cccagccgtg cgcggccggg cccttggcca
    23641 gctccgcctc cagctgcgcg aactgcttct gactcagcct cggcagcgac gccggcccct
    23701 gtgaccgcag ggcccgcggc ccgccctcgt cccacatccg ccgccatcgc tgcaccgagc
    23761 ggacgctgac ccgcaagtcc atggcgatcg ccgagctcgc ctcgccccgg gcgaacctct
    23821 tggccgcctt gagccgtaac ttctcgcgga ac
//
