LOCUS       NZ_BBOK01000001        21161 bp    DNA     linear   CON 17-AUG-2024
DEFINITION  Streptomyces sp. NBRC 110030, whole genome shotgun sequence.
ACCESSION   NZ_BBOK01000001
VERSION     NZ_BBOK01000001.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. NBRC 110030
  ORGANISM  Streptomyces sp. NBRC 110030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Katano-Makiyama,Y., Hosoyama,A., Hashimoto,M., Tsuchikane,K.,
            Uohara,A., Kitahashi,Y., Ohji,S., Ichikawa,N., Kimura,A.,
            Yamazoe,A., Komaki,H., Igarashi,Y. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Streptomyces sp. NBRC 110030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 973929)
  AUTHORS   Hosoyama,A., Kimura,A., Ohji,S., Ichikawa,N., Yamazoe,A. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2014) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 97x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina HiSeq 1000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001417675.1-RS_2024_08_17
            Annotation Date                   :: 08/17/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,152
            Genes (coding)                    :: 7,019
            CDSs (with protein)               :: 7,019
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 45 of 133
            Pseudo Genes (incomplete)         :: 107 of 133
            Pseudo Genes (internal stop)      :: 8 of 133
            Pseudo Genes (multiple problems)  :: 23 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:33:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 171484
            Orig. end                         :: 192645
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBOK01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21161
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21161
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11161](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11161)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(51..260)
                     /locus_tag="APK71_RS00750"
     CDS             complement(51..260)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384656.1"
                     /locus_tag="APK71_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_030400624.1"
                     /transl_table=11
                     /translation="MSEATDLATRAGDRDPRVGLRAVAALRKLVEQLEAVQVRSARQRG
                     WSWQEIATELGVSRQAVHKKYGRH"
     gene            complement(397..1362)
                     /locus_tag="APK71_RS00755"
     CDS             complement(397..1362)
                     /NRPS_PKS="Domain: PKS_ER (20-318). E-value: 3e-34. Score:
                     110.5. Matches aSDomain:
                     nrpspksdomains_APK71_RS00755_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571395.1"
                     /locus_tag="APK71_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_030400625.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 8e-21, bitscore:
                     70.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAVYAARIDRDQPLAGLELGELPAPEARPGWSVVDVRAASLNHH
                     DLWSLRGVGLPEDRLPMILGCDAAGVDADGNEVVLHSVIGQSGHGVGPKEPRSILTERY
                     PGTFAEQVAVPTWNVLPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAG
                     GGVATAAIVLGKAAGLRVFATSRDEAKRKRALELGAVEAVETGARLPQRVDAVIETVGA
                     ATWSHSIKSLRPGGTLVISGATSGDRPSHAELTRIFFLELKVVGSTMGSKDELEDLLSF
                     CAATGVRPVIDEVLPMDRAREGFERMASGGQFGKIVLSNS"
     aSDomain        complement(409..1302)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_APK71_RS00755_PKS_ER.1"
                     /evalue="3.00E-34"
                     /label="APK71_RS00755_PKS_ER.1"
                     /locus_tag="APK71_RS00755"
                     /protein_end="318"
                     /protein_start="20"
                     /score="110.5"
                     /tool="antismash"
                     /translation="GELPAPEARPGWSVVDVRAASLNHHDLWSLRGVGLPEDRLPMILG
                     CDAAGVDADGNEVVLHSVIGQSGHGVGPKEPRSILTERYPGTFAEQVAVPTWNVLPKPK
                     ELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGKAAGLRVFA
                     TSRDEAKRKRALELGAVEAVETGARLPQRVDAVIETVGAATWSHSIKSLRPGGTLVISG
                     ATSGDRPSHAELTRIFFLELKVVGSTMGSKDELEDLLSFCAATGVRPVIDEVLPMDRAR
                     EGFERMASGGQFGKIVL"
     CDS_motif       complement(850..903)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS00755_0002"
                     /evalue="6.00E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="APK71_RS00755"
                     /protein_end="171"
                     /protein_start="153"
                     /score="15.7"
                     /tool="antismash"
                     /translation="GDSVLVQGAGGGVATAAI"
     CDS_motif       complement(934..972)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_APK71_RS00755_0001"
                     /evalue="5.60E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="APK71_RS00755"
                     /protein_end="143"
                     /protein_start="130"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AACLPTAWLTAYR"
     gene            complement(1657..2886)
                     /locus_tag="APK71_RS00760"
     CDS             complement(1657..2886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997977.1"
                     /locus_tag="APK71_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent malic enzyme"
                     /protein_id="WP_055467350.1"
                     /transl_table=11
                     /translation="MAAEIVNPRSDSAAGAEQGEGVEPLDSFDPAFALHRGGKMAVQAT
                     VPVRDKEDLSLAYTPGVAKVCSAIAGQPDLVHDYTWKSSVVAVVTDGTAVLGLGDIGAE
                     ASLPVMEGKAILFKQFGGVDAVPLALNCTDADDIVETVVRLAPSFGGVNLEDISAPRCF
                     EIERKLQERLDIPVFHDDQHGTAVVTLAALRNAARLSGRTLGELRAVISGAGAAGVAIA
                     KMLVEAGIGDVAVADRKGVVSADRDDLTPVKQELASFTNKAGLSGSLEVALAGADVFIG
                     VSGGTVPETAVASMAKGAFVFAMANPNPEVHPEVAHKYAAVVATGRSDFPNQINNVLAF
                     PGIFAGALQVRASRITEGMKLAAAEALASVVGDDLAADYVIPSPFDERVAPAVTAAVAA
                     AARAEGVARR"
     misc_feature    complement(3227..3241)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.43"
                     /tool="antismash"
     misc_feature    3411..3426
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.94"
                     /tool="antismash"
     gene            3525..4487
                     /locus_tag="APK71_RS00765"
     CDS             3525..4487
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973710.1"
                     /locus_tag="APK71_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_030400627.1"
                     /transl_table=11
                     /translation="MTARSTRRTTAARFRLTAVGAIAVAGALLLTGCGDQTEKGDSGSS
                     DNQSSGGAPLADKLPQSIRDKGTIKVGSDIAYAPVEFKDDSGKTVGIDPDLADALGKQL
                     GVKFEFENGTFDTLITGLRSKRYDIAMSAMTDTKDRQEGIDADTGKKVGQGVDFVDYFT
                     AGVSIYTKKGDDRGVKTWSDLCGKKLVVQRGTVSEDLAKSENKKCPAGKKISMEAFDND
                     QQAQTRLRAGGADAGSSDFPVAAYAVKTSGGGKDFELVGEQVEAAPYGIAVAKDNTQLR
                     DALKAALDAVIANGDYKKIMDKWGVAEGAVTQAVVNGGK"
     gene            4518..5459
                     /locus_tag="APK71_RS00770"
     CDS             4518..5459
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983523.1"
                     /locus_tag="APK71_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_031082654.1"
                     /transl_table=11
                     /translation="MTVDIEKTAGGPPGTPPTRPEAIKAIPVRHYGRYVSAVVAIALLA
                     AVVYAFSQGKINWGAIPDYFFDDRVLTGMGKTLLITVLAMLIGIVGGILLAVMRLSKNP
                     VTSSLAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGL
                     GLNEAAYMAEICRAGLLAVDEGQTEAAHALGMSHAKTLRRIVVPQAMRVIVPPTGNEVI
                     NMLKTTSLVSVVQYAELFRVAQDIGQTSGAPAEMLFLAAAWYLLLTSVFSVGQYYLERY
                     YARGSSRQLPPTPWQKVRANMFSLGRPKGGMA"
     gene            5513..6265
                     /locus_tag="APK71_RS00775"
     CDS             5513..6265
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973712.1"
                     /locus_tag="APK71_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_053637570.1"
                     /transl_table=11
                     /translation="MVKAEGVHKSFGAVEVLKGIDLEVKQGEVFCLIGPSGSGKSTFLR
                     CINHLEKINAGRLYVDGELVGYRQKGDRLYELKDSEVALKRRDIGMVFQRFNLFPHMTA
                     LENVMEAPVQVKGVGKAQARDRARALLERVGLGDKAGNYPSQLSGGQQQRVAIARALAM
                     DPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMVVVTHEMGFAREVGDSLVFMDDG
                     VVVESGNPRDVLTDPQHDRTKAFLSKVL"
     gene            complement(6340..7170)
                     /locus_tag="APK71_RS00780"
     CDS             complement(6340..7170)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983528.1"
                     /locus_tag="APK71_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_055467351.1"
                     /transl_table=11
                     /translation="MTDADTTNAATGTTTGTTTGTTAGTPTAAGADWQAWQRSWDRQQE
                     WYMPDREERFRIMLDMVEALVGPAPRVLDLACGTGTITARLLDRFPEATSTGVDLDPAL
                     LAIAEGTFAGDERVSFVAADLKDPDWPTTLPYDAYDAVLTATALHWFHAEPLADLYGRV
                     AGLVRDGGVFMNADHMIDDTTPRINAAERAQRHARMDAAKEEGALDWSEWWQLAAKDPV
                     LAAPTARRFEIYGEHADGEMPSAAWHARVLREKGFGEARPVWCSPSDTLLLAVK"
     gene            7270..7899
                     /locus_tag="APK71_RS00785"
     CDS             7270..7899
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326935.1"
                     /locus_tag="APK71_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABATE domain-containing protein"
                     /protein_id="WP_030400631.1"
                     /transl_table=11
                     /translation="MELAYYSDYAVRLVNTEEPSRGQDSLTSVEAVRELFGANQSAARR
                     ASDADVTRFRSVRGRLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRAEDGS
                     PLWHMHLADHPSNATAGFAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSR
                     RYCSDRCATRANVAAYRARKRLEADRSAGTGLTADSAQRTTANGDR"
     gene            complement(7803..8237)
                     /gene="sodX"
                     /locus_tag="APK71_RS00790"
     CDS             complement(7803..8237)
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016485 - protein processing [Evidence
                     IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925778.1"
                     /locus_tag="APK71_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nickel-type superoxide dismutase maturation
                     protease"
                     /protein_id="WP_037798582.1"
                     /transl_table=11
                     /translation="MPEQVSQETERPRGALPFGPAEVTGPSMVPTLHHGDVLLVHWGAR
                     VRPGDVVVLRHPFQQDLLVVKRAAERRGSGWWVLGDNAFAGGDSTDYGVVPQDLVLGRV
                     RFRYRPRAGQRSPFAVVRWALSAVRPVPADRSASRRLRAR"
     gene            8383..8778
                     /gene="sodN"
                     /locus_tag="APK71_RS00795"
     CDS             8383..8778
                     /EC_number="1.15.1.1"
                     /GO_function="GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sodN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313646.1"
                     /locus_tag="APK71_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="superoxide dismutase, Ni"
                     /protein_id="WP_003973716.1"
                     /transl_table=11
                     /translation="MLSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN
                     DDPHFQTRATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKG
                     SKDPATGQKALDYIAQIDKIFWETKKA"
     gene            complement(8907..9491)
                     /locus_tag="APK71_RS00800"
     CDS             complement(8907..9491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973718.1"
                     /locus_tag="APK71_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_055467561.1"
                     /transl_table=11
                     /translation="MRKLTYFIACSIDGFIGGPDGDASFMIPFVDEEFMEFLKAEYPET
                     LPTHSRRPLGIDDLPNKRFDTIIQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDP
                     NVEIISTDLVGRVRELKAEDSAFGIYLCGGAAVAGELVDEVDELVIKTYPVIMGTGMPM
                     FASGFQVSEFVPESVRTFGNGVVVRTYRRKH"
     gene            complement(10001..11161)
                     /locus_tag="APK71_RS00805"
     CDS             complement(10001..11161)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973720.1"
                     /locus_tag="APK71_RS00805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_055467352.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.9e-61, bitscore:
                     203.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESRRGATATPPSTGAPEGHGLIGTQRDKEPGEPPGGQGPVGAE
                     GHEAAVLLRESRASVDPELRSAIASLPDAMRRIALYHFGWQHADGTPAAGNAGKAIRPA
                     LVLTAATALGGPAARAAARRAAAAVELVHNFTLLHDDVMDRDATRRHRPTAWTVFGDAD
                     AILAGDALQALALRLLAADPHPASAAAAARLADCVMELCEGQHADTAMEGRPPQGVTLD
                     ETLTMAEAKTGALLGCACALGALYAGAPAEDVEALDAFGREAGLAFQLIDDVIGIWGDP
                     RHTGKPAGADLAARKKSLPVVAALTSGTPAAAELAELYAVPYDQGREDLERTALVVERA
                     GGRDWAQAQAADRMARAMQELARAVPDPEAAGGLLALAEFVTRRST"
     misc_feature    11189..11204
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.7"
                     /tool="antismash"
     gene            complement(11247..12653)
                     /locus_tag="APK71_RS00810"
     CDS             complement(11247..12653)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136651.1"
                     /locus_tag="APK71_RS00810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_030400635.1"
                     /transl_table=11
                     /translation="MSVGEEVRTEQTRPQQSLGTAAARNLATTTKSVPQMQEISSRWLL
                     RTLPWVDIQGGTYRVNRRLTFAVGDGRVTFVKTGDRVEVIPAELGELPALRSYEDDEVL
                     SELAQRCEQREFGPGEVIASFGGRADEVYLLAHGKIEKIGTGPYGDDAVLGVLADGAYF
                     GDQALLDGDAIWEYTARTVTACTVLALPRQQVEQVAERAESLRAHLEQARAIPEQRTNK
                     HGEKEIDLSAGHSGEPDIPHTFVDYEARPREYELSVAQTVLRIHSRVADLYNQPMNQTE
                     QQIRLTVEALKERQEHELINNREFGLLHNCEYDQRIQPHDGVPGPDDLDELLSRRRGTK
                     LLLAHPRAIAAIGRELNKRGLVPETIDVGGNRIPTWRGVPIYPCNKIPVTEARTSSIIA
                     MRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAIIKYLVTAYYSAAVLVPDALGV
                     LENVEIGRWR"
     misc_feature    complement(12721..12734)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.09"
                     /tool="antismash"
     gene            12994..13584
                     /locus_tag="APK71_RS00815"
     CDS             12994..13584
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142330.1"
                     /locus_tag="APK71_RS00815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_030400636.1"
                     /transl_table=11
                     /translation="MASPMSASSFLKALKAEGLTVVEVGDWRDHNRNHKGPWGPVHGVM
                     IHHTVTEGSERTVDICRKGHEDLPGPLCHGVVTKDGTVHLVGYGRANHAGLGDDDVLRA
                     VIAEKALPRDNEAGTDGNRHFYGFECENLGDGADPWPEAQLEAIERAAAAVCRHHGWNE
                     RSVIGHLEWQPGKVDPRGFTMASMRERIRDRLK"
     gene            13678..14577
                     /locus_tag="APK71_RS00820"
     CDS             13678..14577
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973723.1"
                     /locus_tag="APK71_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-aminocyclopropane-1-carboxylate
                     deaminase/D-cysteine desulfhydrase"
                     /protein_id="WP_030400637.1"
                     /sec_met_domain="PALP (E-value: 2.3e-17, bitscore: 59.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTDTDALRPRLPSPVQEVADGRFERRGVRLLLKRDDLIHPELI
                     GNKWRKLAPNLAPAAGRAVVTFGGAYSNHLRATAAAGRLLGLPTVGVVRGQELAGRPLN
                     PSLARCAADGMRLHFVDRATYRRKTEPETLAALLRAVEAEDALVVPEGGSNARAVRGCR
                     ALGEELGEHADVAAVACGTGGTLAGLAAGLPPGRRALGIPVLKGGFLEGDIRRLQEGAF
                     GGPCGTWSLEDRFHHGGYARTTPALDAFAEDFEHRHGLPVERVYVAKLLFALLALTEEG
                     AFPRGTTLAAVVTGRPFP"
     gene            complement(14607..16199)
                     /locus_tag="APK71_RS00825"
     CDS             complement(14607..16199)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973724.1"
                     /locus_tag="APK71_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_030400638.1"
                     /transl_table=11
                     /translation="MDVMPLLLLVAGSAAVAAAGRRVPVPVPLLLVAAGLAVSYVPGVP
                     DYTLDPHVVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLI
                     VPGLPLTAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVA
                     LAAAVGEGTTWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFV
                     AYAVAEQVHASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGL
                     QLPVVLRGLGEIEGLDAAWYALAVFLVVAVARFVWVYPATFLPRLSARVRAREGALSWK
                     APFVIGWAGMRGVVSLAIAFSIPLTVHGGAPFPERNLVLFLTFTTVIGTLVVQGVSLPP
                     LIRLLKFPAHDVQAETLAEANAQAQASRVAEERLDALLADERNTLPAPLADRLRTVLER
                     RRNAVWERLGQVNPVTGETVDDTYRRLSREMISAEREVFVRLRDGRYIDDEMLRTLLRR
                     LDLEEAAAYRETT"
     gene            16261..16521
                     /locus_tag="APK71_RS00830"
     CDS             16261..16521
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571357.1"
                     /locus_tag="APK71_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_030400639.1"
                     /transl_table=11
                     /translation="MKQCTHADALPHPEPEPCGETCPECLAEGTDPVQLRLCLSCGHVG
                     CCDSSPRQHATAHHKETGHPVMRSFEPGESWRWCFVDHVLV"
     misc_feature    complement(16618..16633)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    complement(16630..16643)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            16772..17185
                     /locus_tag="APK71_RS00835"
     CDS             16772..17185
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985353.1"
                     /locus_tag="APK71_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_003973726.1"
                     /transl_table=11
                     /translation="MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTV
                     LSALAGKVSSAVDEDKTVSISLYKQRGAGPGPT"
     gene            17209..18273
                     /locus_tag="APK71_RS00840"
     CDS             17209..18273
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136656.1"
                     /locus_tag="APK71_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_078869380.1"
                     /transl_table=11
                     /translation="MRDEERGTRELPAEGTRSPNEVRRTADGIDGIPEQARPHPEDETS
                     PEAVVPGGGQRTGGTPVRPVRAEARARERATGGTMSEHERHADGHAPGARGTQGTRHDP
                     QDRSGARLLFAELRTLAKDSPEYAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVA
                     TIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTAT
                     AELSQLHGRSPTVHELAEKLSISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLG
                     AEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLA
                     RTLAQLREKLLVEE"
     gene            complement(18311..18763)
                     /locus_tag="APK71_RS00845"
     CDS             complement(18311..18763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444616.1"
                     /locus_tag="APK71_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030400641.1"
                     /transl_table=11
                     /translation="MSSEQTPDPASAASEEAEPRPARVTAAAAIAALEGLALVVGGAWM
                     LVGGLTGHPDDRTSAVTGGITLIVLALLPLLAARGLLRLKGWSRGPAVITQILALPVAY
                     NMAGADSLAVPAGAVLGVLALAALYMLINPETTLALGIRGPGNARK"
     gene            18898..19866
                     /locus_tag="APK71_RS00850"
     CDS             18898..19866
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134762.1"
                     /locus_tag="APK71_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_030400642.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAARSDDIDLVVALGGDGTVNEVVNGLLHAGPDPEHLPGLAVVPGGSTNVFARALG
                     LPNHAVEATGALLDALREGSERTVGLGLASGTPGTEDEAVPARWFTFNAGLGFDAGVVG
                     RVEQHRERGRKSTHALYVRQVVRQLIGEPHRRSGTITLEREGEDPVTDLVLSIVSNTCP
                     WTFLGNRPIYASPEASFDTALDVFGLSRLSTAAVARYGTQLLTSSPERGPRGRHAVSLH
                     DLTDFTLHSKVPLPLQMDGDHLGLRTSVTFTGVRRALRVIV"
     misc_feature    complement(19951..19965)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.74"
                     /tool="antismash"
     misc_feature    complement(19956..19965)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(20127..20142)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    20130..20141
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            20187..20444
                     /locus_tag="APK71_RS00855"
     CDS             20187..20444
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563321.1"
                     /locus_tag="APK71_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_003973730.1"
                     /transl_table=11
                     /translation="MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA"
ORIGIN
        1 gacggccccc tgcacgaccg cccgggcgtc cttcgtgaat cgctcgaaca tcaatgcctc
       61 ccgtacttct tgtgcacggc ctgcctgctg accccgagct ccgtggcgat ctcctgccac
      121 gaccaccctc gctggcgtgc gctgcgcacc tgcaccgcct ccagctgctc caccagcttt
      181 cgcagggcgg cgacggcccg cagcccgacc cggggatcgc ggtcacccgc acgcgtggcg
      241 agatccgttg cttcgctcat gctgtcaacg taggttgaca cccctcgatt gtcaacctcc
      301 gttgacgggc gaggaggccg ggcgaggcac gcgaacggcg ggcccggagc accggacccg
      361 ccgtacacgg gaggaagagg aagaagccgg ggcggctcag gagttgctga gcacgatctt
      421 gccgaactgc ccccccgagg ccatccgctc gaacccctca cgggcccggt ccatcggaag
      481 cacctcgtcg atgacgggac gcacccccgt ggcggcgcag aaggacagca ggtcctccaa
      541 ctcgtccttg gagcccatcg tggagccgac gaccttgagt tccaggaaga agatccgggt
      601 cagctcggcg tgggagggcc ggtcaccgct ggtggcaccg gagatgacca gcgtgccgcc
      661 gggccgcagc gacttgatgg agtgcgacca ggtggcggcg cccaccgtct cgatgacggc
      721 gtcgacccgc tgcggcagcc gcgccccggt ctcgacggcc tcgacggcgc cgagctccag
      781 cgcccgcttg cgcttggcct cgtcacggct ggtcgcgaag acccgcagcc ccgcggcctt
      841 gccgagcacg atcgcggccg tggcgacccc gccgccggca ccctgcacca gcaccgagtc
      901 gccgggacgc accccggcgt tggtgaacag catccggtac gccgtcagcc aggcggtcgg
      961 caggcaggcg gcctcctcga aggagagctc cttgggcttg ggcaggacgt tccaggtcgg
     1021 cacggcgacc tgctccgcga acgtccccgg atagcgctcg gtgaggatgg agcggggctc
     1081 cttgggaccg accccgtggc cgctctggcc gatgacggag tgcaggacga cctcgttgcc
     1141 gtccgcgtcg accccggcgg cgtcgcagcc caggatcatc ggcaaccggt cctcggggag
     1201 accgacgccg cgcagggacc acaggtcgtg gtggttgagg gaggcggccc tgacatcgac
     1261 gacgctccag ccgggccggg cctcgggagc cggaagctct cccaactcca gtccggccaa
     1321 gggctggtcg cggtcgattc gggcggcgta gacagcgaac atgacctcga cgatagattc
     1381 cccacccccc gaccgaaacc gcggcgccgt gtgacacacc ccctcttgcg cacaccgccg
     1441 cagccgcaga cgcagacggc cacgcgccgc cccggctgcg ggcagtcgag ccgcccccgg
     1501 tgcctgaacg gcctgggaga cacccccagg caccccaggc acccccaggc acccccgggc
     1561 agcaccggcc cccgcgaccc gcccgcgtcc aaaaaaacga gcgaccccgc cccccgaggg
     1621 acgaggccgc tcaccgcacc gcggacgttc acaccgtcac cggcgcgcaa ccccctccgc
     1681 ccgggccgcc gcggccaccg ccgccgtcac cgccggagcg acccgctcgt cgaacgggga
     1741 cgggatgacg tagtccgccg cgaggtcgtc ccccaccacg gaggccagcg cctcggccgc
     1801 cgcgagcttc atgccctcgg tgatccggga ggcccgcacc tgcagcgccc ccgcgaagat
     1861 gcccgggaac gccagcacgt tgttgatctg gttcgggaag tccgagcgcc ccgtcgcgac
     1921 gaccgccgcg tacttgtggg cgacctccgg atgcacctcg gggttcgggt tggccatcgc
     1981 gaagacgaac gcgcccttcg ccatcgaggc caccgccgtc tccggcaccg tgccgccgga
     2041 gacgccgatg aagacgtcgg cgcccgcgag ggccacttcc agcgagcccg agagccccgc
     2101 cttgttggtg aaggaggcca actcctgctt gaccggcgtc aggtcgtccc ggtcggccga
     2161 gacgacgccc ttgcggtcgg cgaccgcgac gtccccgata ccggcctcga ccagcatctt
     2221 ggcgatggcc accccggccg cgcccgcgcc cgagatcacc gcccgcagtt cgcccagcgt
     2281 ccgcccgctc agccgcgccg cgttgcgcag cgccgccagc gtcacgacgg ccgtgccgtg
     2341 ctggtcgtcg tggaagaccg ggatgtccag gcgctcctgg agcttgcgct cgatctcgaa
     2401 gcaccgcggc gccgagatgt cctccaggtt cacgccgccg aaggagggcg cgagccggac
     2461 cacggtctcg acgatgtcgt cggcgtccgt gcagttcagg gcgagcggga ccgcgtccac
     2521 gccgccgaac tgcttgaaga ggatggcctt gccctccatc acgggaaggg acgcctcggc
     2581 cccgatgtcc ccgagcccca gcaccgccgt gccgtccgtc acgaccgcga cgaccgacga
     2641 cttccaggtg tagtcgtgga cgaggtccgg ctgcccggcg atcgcgctgc acactttcgc
     2701 gacgccgggt gtgtacgcca gggacaggtc ttccttgtcg cggaccggca cggtggcctg
     2761 cacggccatc ttgccgccgc ggtgcagcgc gaacgcgggg tcgaaggagt cgagcggctc
     2821 gacgccctcc ccctgttccg caccggcggc gctgtcgctg cgaggattga cgatctccgc
     2881 tgccactttg tcttacccct taagagttca tggattgagg gttttgtcca ctcctggtga
     2941 ggaatgggcg ggcaccgcac agggagatgg ctgtacgggc cacgaggccc ctgcgcgacg
     3001 ggcgcgccgc acacgcgccc tgagcccctg atgaggggtg taaagaacct tcttacccga
     3061 cggaccgccc tcgcgacgag tccgataagc gcaagctcac atgccggacc ccgaacgccg
     3121 catgtcggtg acaagcctca tagccagggt tccggacaac cttcccgcac cccttgacag
     3181 acccgccgac gccaccttcc acgaccctgt cgacgcgcag tccatgttcg gataacgaga
     3241 aattccgtag atcttccggc cggaagggca gattcccgca aaggttcggt cgtgttgtac
     3301 cgacctggtg cggttcgggg tgtgacccgt tatccgattt tgacatgacg tcccccctga
     3361 atggccgagt ccgaatggca agatgccgta atcacacgag gtcgcagcac tcgaaggtgt
     3421 gtgctcccgt cgacccacga cgccggtcgg ccccggccgg cgtcccgtcc cacggaaccc
     3481 gaccgtcccc atcggctact ccctcatccg ccggaggaac caccatgacc gcacgctcca
     3541 cccgtcgtac gaccgccgcg cgcttccggc tgacagcggt cggtgcgatc gcggtcgcag
     3601 gcgccctgct gctcaccggc tgcggcgacc agaccgagaa gggcgactcc ggcagcagcg
     3661 acaaccagtc ctccggcggc gctccgctgg ccgacaagct cccgcagtcg atccgcgaca
     3721 agggcaccat caaggtcggt tccgacatcg cgtacgctcc cgtcgaattc aaggacgact
     3781 ccggcaagac cgtcggtatc gaccccgatc tggcggacgc cttgggcaag cagctcggcg
     3841 tgaagttcga attcgagaac ggcaccttcg acacgctgat caccggcctg cgctccaagc
     3901 ggtacgacat cgccatgtcc gcgatgaccg acaccaagga ccgccaggag ggcatcgacg
     3961 ccgacaccgg caagaaggtc ggccagggcg tcgacttcgt cgactacttc accgccggtg
     4021 tctcgatcta caccaagaag ggcgacgacc gcggcgtcaa gacctggtcc gacctgtgcg
     4081 gcaagaagct cgtggtccag cgcggcacgg tctccgagga cctcgccaag tccgagaaca
     4141 agaagtgtcc ggccggcaag aagatctcca tggaggcctt cgacaacgac cagcaggccc
     4201 agacccgcct gcgcgcgggc ggcgcggacg ccggttcctc cgacttcccg gtcgcggcct
     4261 acgcggtgaa gacctccggc ggcggcaagg acttcgagct cgtcggcgag caggtcgagg
     4321 ccgccccgta cggcatcgcg gtcgccaagg acaacacgca gctccgcgac gccctgaagg
     4381 cggcgctgga cgcggtgatc gccaacggtg actacaaaaa gatcatggac aagtggggcg
     4441 tggcggaagg cgccgtcacc caggccgtcg tcaacggcgg caagtgaccg ggcggtgggc
     4501 gctgaaaggc agtatccgtg actgttgaca tcgagaagac ggcgggcggc ccgcccggca
     4561 ccccgccgac ccgtccggag gccatcaagg ccatcccggt ccggcactac gggcggtacg
     4621 tgtccgcggt cgtcgcgatc gcgctgctgg ccgcggtcgt gtacgcgttc tcccagggca
     4681 agatcaactg gggtgcgatc ccggactact tcttcgacga ccgcgtcctg accggcatgg
     4741 gcaagacgct gctgatcacc gtcctcgcga tgctgatcgg tatcgtcggc ggcatcctgc
     4801 tggccgtgat gcggctgtcg aagaacccgg tgacctcgtc cctcgcgtgg ttctacatct
     4861 ggttcttccg cggcacgccg gtcctggtgc agctcgtcgt ctggttcaac ctgggcctgg
     4921 tcttcgagta catcaacctc ggcccgttct accgcgacga gtggtcggac ttcatgacgc
     4981 cgttcctgac ggcgctcctc ggcctcggcc tcaacgaggc cgcgtacatg gcggagatct
     5041 gccgcgccgg tctgctcgcg gtcgacgagg gccagaccga ggcggcgcac gcgctcggca
     5101 tgagccacgc caagacgctg cgccggatcg tggtcccgca ggcgatgcgc gtcatcgtgc
     5161 cgccgacggg caacgaggtc atcaacatgc tgaagacgac ctccctggtg tcggtcgtcc
     5221 agtacgccga gttgttccgg gtcgcccagg acatcggcca gacctccggc gccccggccg
     5281 agatgctgtt cctggccgcg gcctggtacc tgctgctgac ctcggtcttc agcgtcggcc
     5341 agtactacct ggagcggtac tacgcccgcg gttccagccg ccagttgccg ccgacgccgt
     5401 ggcagaaggt cagggcgaac atgttctccc tcggccgccc gaagggaggc atggcatgac
     5461 cgggaagctc gccaggacgg acggtgcccg cgtgcgggac tccgccgtcc ccatggtcaa
     5521 ggcggagggc gtccacaagt ccttcggcgc cgtcgaggtc ctcaagggca tcgacctgga
     5581 ggtgaagcag ggcgaggtgt tctgcctcat cgggccctcc ggctccggca agtcgacgtt
     5641 cctgcgctgc atcaaccacc tggagaagat caacgccggg cggctgtacg tcgacggcga
     5701 gctggtcggc taccgccaga agggtgacag gctctacgag ctgaaggaca gcgaggtcgc
     5761 cctcaagcgc cgggacatcg gcatggtctt ccagcgcttc aacctcttcc cgcacatgac
     5821 ggccctggag aacgtcatgg aggcgccggt gcaggtgaag ggcgtgggca aggcccaggc
     5881 cagggaccgc gcgcgggccc tgctggagcg ggtgggcctt ggcgacaagg ccggcaacta
     5941 cccctcgcag ctctccggcg gccagcagca gcgcgtcgcc atcgcgcggg ccctggcgat
     6001 ggacccgaag ctgatgctgt tcgacgagcc gacctcggcg ctcgaccccg agctggtcgg
     6061 cgacgtcctc gacgtcatgc gcgacctcgc cgagtccggc atgaccatgg tcgtcgtcac
     6121 ccacgagatg ggcttcgccc gcgaggtcgg cgacagcctg gtcttcatgg acgacggcgt
     6181 ggtcgtcgag tccggcaacc cgcgcgacgt cctgaccgac ccgcagcacg accggacgaa
     6241 ggcgttcctg tccaaggtcc tctgagacca cgtccaccac aggggcggta caggactccc
     6301 gtaccgcccc ttccggctgc cgtcctcgtc gtcaacggct cacttcacgg ccagcagcag
     6361 ggtgtccgag ggcgagcacc acaccgggcg cgcctcgccg aagccctttt cccgcaggac
     6421 gcgcgcgtgc cacgccgccg agggcatctc gccgtcggcg tgttcgccgt agatctcgaa
     6481 gcggcgggcg gtgggagcgg cgagcaccgg gtccttggcg gcgagctgcc accactcgga
     6541 ccagtccagg gcgccctctt ccttggcggc gtccatccgc gcgtgccgct gcgcgcgctc
     6601 ggccgcgttg atccggggcg tcgtgtcgtc gatcatgtgg tccgcgttca tgaagacacc
     6661 accgtcgcgg accagccccg cgacccgacc gtagagatcc gcgaggggtt cggcgtggaa
     6721 ccagtgcagg gccgtggcgg tcagcacggc gtcgtacgcg tcgtacggca gcgtcgtcgg
     6781 ccagtcgggg tccttgaggt cggcggcgac gaaggagacc cgctcgtcgc ccgcgaaggt
     6841 gccctcggcg atggcgagga gcgccgggtc gaggtccacg ccggtgctgg tggcctccgg
     6901 gaaccggtcg agcagccggg ccgtgatggt gccggtgccg caggccaggt cgagcacgcg
     6961 cggcgcgggg ccgacgagcg cctcgaccat gtcgagcatg atccggaacc gttcctcgcg
     7021 gtccggcatg taccactcct gctgccggtc ccagctccgc tgccatgcct gccagtcggc
     7081 accggccgcc gtgggcgtcc cggcggtcgt gccggtagtc gtgccagtgg tcgtgccggt
     7141 ggccgcgttc gtggtgtccg cgtcggtcat cgagcccctc cgtacctgcg tcacgtaata
     7201 ccctgtaagc acgatcagcc attacctgac cgcaggcacg accctagagc cccttcgtaa
     7261 ggactacaag tggaactggc ctattactcg gattacgccg tacgtctcgt caacaccgag
     7321 gaaccctcac ggggccagga ctccctgacc tcggtggagg ccgtccgtga actcttcggc
     7381 gccaaccagt cggcggcccg gcgcgcctcc gacgccgacg tgacgcggtt ccgctcggtc
     7441 cgggggcggc tgcgcgcggt cttcgaggcg gccgacggcg gcgacgagac cctcgccgtg
     7501 gacctgctga actccctgct cctggaattc ccggtgagcc cgcagatctc cggccacgac
     7561 caccgcgcgg aggacggcag cccgctgtgg cacatgcacc tggcggacca cccctccaac
     7621 gcgaccgccg gcttcgccgc catcgcggcg atgggcctgg ccttccacct caccgagtac
     7681 ggcgtcgacc ggctgggcct gtgcgaggcg gccccctgcc gcaacgccta cctggacacc
     7741 tcgaccaacc gctcccggcg ctactgctcc gaccgctgcg cgacccgcgc caacgtggcg
     7801 gcctaccgcg cccgcaagcg cctggaggcg gaccggtcgg ccggcaccgg cctgaccgcc
     7861 gacagcgccc agcggaccac ggcgaacggc gaccgctgac cggccctcgg ccggtaccgg
     7921 aaccggaccc ggccgaggac gaggtcctgc gggacgacgc cgtagtcggt gctgtccccg
     7981 cccgcgaacg cgttgtcccc gagcacccac cagccggacc cccgccgttc ggccgcccgc
     8041 ttgaccacga gcaggtcctg ctggaaggga tgccgcagca ccaccacgtc acccggacgg
     8101 acccgcgccc cccagtgcac gagcagcacg tcaccgtggt gcagcgtggg caccatcgac
     8161 ggcccggtca cctcggccgg cccgaagggc aacgcccctc tcgggcgctc ggtctcctgc
     8221 gacacttgct ccggcatcac ccggcacctc cccggtcttt cctccaccag tctcagtctc
     8281 accccggact tttgtcctaa gcccacgggg gcacccgcga aatcggtcct cccagggagt
     8341 aatgtccccc ctgagaagac gatcacgagg aaggaacgct tcatgctttc ccgcctgttt
     8401 gcccccaagg tcacggtcag cgcccactgc gacctgccct gcggcgtgta cgacccggcc
     8461 caggcccgca tcgaggcgga gtcggtgaag gccgtccagg agaagatggc cggcaacgac
     8521 gacccgcact tccagacgcg cgccacggtc atcaaggagc agcgcgccga gctcgcgaag
     8581 caccacgtct ccgtgctgtg gagcgactac ttcaagcccc cgcacttcga gaagtacccg
     8641 gagctgcacc agctcgtcaa cgacaccctg aaggccctgt cggccgccaa gggctccaag
     8701 gacccggcca ccggccagaa ggccctggac tacatcgccc agatcgacaa gatcttctgg
     8761 gagaccaaga aggcctgacg aaggtccgta cccggggccg gcgatcggtg caccatcgca
     8821 ggccgcaagg gagcccgaag gggcccggcc gccacccggc cgggcccctt ccgcgttgcc
     8881 gccccggacc ggagtcggag ggcggctcag tgcttgcggc ggtacgtccg caccacgacg
     8941 ccgttgccga aggtccgcac cgactccggc acgaactcgg agacctggaa cccggaggcg
     9001 aacatcggca tgccggtacc catgatcacc gggtaggtct tgatgaccag ttcgtcgacc
     9061 tcgtcgacca gttcgccggc gacggccgcc ccaccgcaca ggtagatgcc gaaggcactg
     9121 tcctccgcct tcaactccct gaccctgccg accaggtccg tcgagatgat ctcgacattc
     9181 gggtcgggcg actccgtgag cgtgcgcgag gcgacgtact cgcgcaggtg tgcgtacggg
     9241 ctggtgacgc cctccttgag ggccaggtcg tagctggccc ggccctggat gatcgtgtcg
     9301 aagcgcttgt tcggcaggtc gtcgatgccg agcggccgac ggctgtgcgt cggcagcgtc
     9361 tcgggatact ccgccttcag gaactccatg aactcctcgt cgacgaacgg gatcatgaac
     9421 gacgcgtcgc cgtccggccc gccgatgaag ccgtcgatcg agcaggcgat gaagtacgtg
     9481 agcttgcgca aaccggtctc ccctccgttg accactacgc tcacagtact ccatgcgtag
     9541 ttgtctgggg aagtgccttc tactgggccc gcggctcacg ccgcatcggc cacctgcggg
     9601 ggccgtccgg caggttcagg acccggccgg tgcacgcgag gccgaggcgt tcgtacggca
     9661 ctgacccgtg cgctgctcgc ctccaggcag gcgggcgctc cctcccggtc gcggcggtcg
     9721 agtacgccgc cgatcagcgc gcgatcagcg cgccctccag cccctcgccc tgccgcccgg
     9781 atcaccacac ccgtgacccg cctcttcggg tcaacctcgc tcgcctgtac ggcggctggg
     9841 cccaggccct gcccgacggg aagacaggga ggcgggcccc gcacaccgtg gggaagtgcg
     9901 ggacccgccc gaccggagcc gtcggcggtg cggccgtacg tcggtcaggt gccgtacggc
     9961 cctgcacggg ctccggggtc ttgcacggcc ggcgcggccg tcaggtgctg cgccgggtga
    10021 cgaactcggc cagcgcgagc aggccgcccg ccgcctccgg gtcgggcacg gcccgggcca
    10081 gctcctgcat ggcccgcgcc atccggtcgg ccgcctgggc ctgcgcccag tcccgtccgc
    10141 cggcccgctc caccaccagg gcggtgcgct ccaggtcctc cctgccctgg tcgtacggca
    10201 ccgcgtacaa ctcggccagt tcggcggcgg ccggagtgcc ggaggtgagg gcggcgacca
    10261 ccggcagcga cttcttgcgg gcggccaggt ccgcaccggc cggcttgccg gtgtggcgcg
    10321 ggtcgcccca tatgccgatg acgtcgtcga tgagctggaa ggccagtccc gcctcccggc
    10381 cgaaggcgtc cagggcctcg acgtcctccg cgggggctcc cgcgtacagc gcgccgaggg
    10441 cacaggcgca gcccagcagg gcccccgtct tggcctccgc catggtgagc gtctcgtcga
    10501 gggtgacccc ctgcggtggg cgcccttcca tggccgtgtc cgcgtgctga ccctcgcaca
    10561 gctccatgac gcagtcggcg agccgggcgg cggccgccgc ggacgccggg tgggggtccg
    10621 cggcgagcag ccgcagggcg agcgcctgga gggcgtctcc ggcgaggatc gcgtcggcgt
    10681 cgccgaacac ggtccaggcg gtgggccggt ggcgccgggt ggcgtcccgg tccatcacgt
    10741 cgtcgtgcag cagcgtgaag ttgtggacca gctccaccgc cgccgcggcc cggcgggccg
    10801 ccgcacgggc cgccggcccg ccgagcgcgg tcgccgcggt gaggacgagt gcggggcgga
    10861 tcgccttgcc cgcgttgccc gccgcggggg tgccgtccgc gtgctgccag ccgaagtggt
    10921 agagcgcgat ccggcgcatc gcatcgggca acgacgcgat ggcggagcgc agttcggggt
    10981 ccaccgacgc ccgtgactcc cgcaggagca ccgccgcttc gtgcccttcg gcccccaccg
    11041 gcccctgccc cccgggcggt tcccccggct ccttgtcccg ctgtgtgccg atgagaccgt
    11101 gtccttcggg cgctccggtg gaagggggcg tcgccgtggc gccgcgccgg ctctccgtca
    11161 tggactcacc ttccccctgg gcccgtccgt acccctgggg tgtacccgcc cgcgagggcg
    11221 ggaacacggc gtcggggact gtggcgtcac cgccagcggc cgatctcgac gttctccagg
    11281 acgccgagcg cgtcgggcac gaggaccgcg gccgagtagt aggccgtgac caggtacttg
    11341 atgatggcct gctcgttgat gcccatgaag cgcaccgaca gactcggctc gatctcgtcc
    11401 gggatgccgg tggcccgcag accgatgacg ccctggtcct gctcgccggt acgcatcgcg
    11461 atgatcgaag acgtacgggc ctcggtgacc gggatcttgt tgcacgggta gatcggcaca
    11521 ccgcgccagg tcgggatgcg gttcccgccg acgtcgatcg tctcggggac gagcccgcgc
    11581 ttgttcagct cgcgcccgat ggcggcgatg gcgcgcggat gggcgaggag cagcttggtg
    11641 ccgcgccggc ggctcagcaa ctcgtcgagg tcgtccgggc cgggcacacc gtcgtgcggc
    11701 tggatgcgct ggtcgtactc gcagttgtgc aggaggccga actcgcggtt gttgatgagt
    11761 tcgtgctcct ggcgctcctt caacgcctcg accgtcagcc ggatctgctg ctcggtctgg
    11821 ttcatcggct ggttgtacag atcggccacg cgcgagtgga tgcgcagcac ggtctgggcg
    11881 acgctcagtt cgtactcacg ggggcgggcc tcgtagtcga cgaaggtgtg cgggatatcc
    11941 ggctcgccgc tgtggccggc ggagaggtcg atctccttct caccgtgctt gttggtgcgc
    12001 tgctccggga tcgcgcgcgc ctgttccagg tgcgcgcgca gggactcggc ccgctccgcc
    12061 acctgctcca cctgctggcg gggcagtgcc aggacggtgc aggcggtgac cgtgcgggcg
    12121 gtgtactccc agatggcgtc cccgtccagg agcgcctggt cgccgaagta ggcgccgtcg
    12181 gcgaggacgc cgagcaccgc gtcgtcgccg tagggtccgg tgccgatctt ctcgatcttg
    12241 ccgtgcgcca gcaggtagac ctcgtcggcc cggcccccga acgaggcgat gacctcaccg
    12301 gggccgaact cccgctgctc acagcgctgc gccagctccg acaggacctc gtcgtcctcg
    12361 tacgaacgca gggccggcag ctcgcccagc tcggcgggga tgacctcgac gcggtctccg
    12421 gtcttcacga acgtcacgcg gccgtcgccc acggcgaagg tcaggcgccg gttcacccgg
    12481 tacgtgccgc cctgaatgtc gacccagggg agcgtgcgca gcagccagcg cgagctgatc
    12541 tcctgcatct gaggaacgga cttggtggtg gtggccaggt tccgcgcggc cgccgtgccc
    12601 aggctctgct gcggcctggt ctgctcggtg cggacctctt cgcctaccga cataaggaat
    12661 tgccctcccg gtcatgccgg acgactgcgc ccggcatcga tgtgcgtgga ccacccttcc
    12721 tcacggagcg tgccggtgct attacacgaa agagcgggaa tggatcacgt ccggccgggg
    12781 cagatatggg ggcttgttcg gtgtctccct gacatgtccg gctccgtcgg ggcctgcccc
    12841 gtcccgtccc cccgccgccc ctggcccgga cggggttgtc cgaaacggct cgcacacggg
    12901 ccgaacaagc aatagacgac gctccgtttc ggtacaagct ccgtacgaga cggtcgcgcc
    12961 gggcggtcgt cgcgcagcgc gaaggagtcg gccatggcct cacccatgtc cgcgagcagc
    13021 ttcctcaagg cactgaaggc ggagggcctc accgtcgtcg aggtgggcga ctggcgggat
    13081 cacaaccgca accacaaggg cccctggggc cccgtgcacg gagtgatgat ccaccacacg
    13141 gtcaccgagg gcagcgagcg gacggtggac atctgccgca agggccacga ggacctgccg
    13201 ggcccgctgt gccacggggt cgtcaccaag gacggcacgg tgcacctggt cggctacggc
    13261 cgcgccaacc acgccggtct cggcgacgac gacgtgctgc gcgccgtcat cgcggagaag
    13321 gcgctgcccc gggacaacga ggccggcacc gacggcaacc gccacttcta cggcttcgag
    13381 tgcgagaacc tcggcgacgg cgccgatccc tggccggagg cccagttgga ggccatcgag
    13441 cgggccgccg cggccgtgtg ccgccaccac ggctggaacg agcggtccgt catcggccac
    13501 ctggagtggc agccggggaa ggtggacccg cgcggattca cgatggcctc gatgcgggag
    13561 cggatccgtg accggctgaa gtgaaccggg cccggccggg gtggatcacc ggccgaggtg
    13621 atccggcagc ggcgaacgcg aggtgtccgc cccgcgcggc ggcgtgacaa tggcggggtg
    13681 accggcaccg acaccgacgc cctgcggccc cgtctgccct ctcccgtgca ggaggtggcc
    13741 gacgggcgct tcgagcggcg cggcgtccgg ctgctgctca agcgggacga tctgatccac
    13801 cccgagctga tcggcaacaa atggcgcaag ctggcgccga atctcgcccc ggcggccggc
    13861 cgcgcggtcg tgaccttcgg cggcgcctac tccaaccacc tgcgggccac ggccgccgcc
    13921 ggccgcctgc tcggcctgcc cacggtgggc gtcgtgcgcg gtcaggaact ggcgggccgg
    13981 ccgctgaacc cgtcgctggc ccggtgcgcc gccgacggca tgcggctgca cttcgtcgac
    14041 cgcgcgacgt accgccgcaa gacggagccg gagacgctgg ccgccctgct gcgcgcggtg
    14101 gaggccgagg acgccctcgt cgtccccgaa ggcggcagca acgcccgggc cgtccggggc
    14161 tgccgcgccc tgggcgagga actgggcgaa cacgccgacg tggccgccgt cgcctgcggc
    14221 accggcggca cgctggccgg gctggccgcc gggctccctc cgggtcggcg ggccctcggc
    14281 ataccggtgc tcaagggcgg cttcctggag ggcgacatac ggcggctcca ggagggcgcg
    14341 ttcggcgggc cgtgcggcac ctggagcctg gaggaccgtt tccaccacgg cggttatgcc
    14401 cgcacgacgc ccgcgctcga cgccttcgcc gaggacttcg agcaccgcca cgggctgccc
    14461 gtggaacgcg tctacgtcgc caagctgctg ttcgccctcc tggcactcac cgaggaaggc
    14521 gccttcccgc gcgggacgac cctggcggcg gtcgtcaccg gccggccctt cccctgagcg
    14581 gcccaccacc gcgtcggcgc accggttcag gtggtctcgc ggtaggccgc cgcctcctcc
    14641 aggtcgagcc ggcgcagcag tgtccggagc atctcgtcgt cgatgtagcg gccgtccctc
    14701 agccggacga agacctcgcg ctcggcgctg atcatctccc gggagagccg ccggtaggtg
    14761 tcgtcgaccg tctcaccggt gacgggattg acctggccga gccgttccca gacggcgttg
    14821 cggcggcgct ccaggaccgt gcgcagacgg tcggcgaggg gggccggcag cgtgttgcgc
    14881 tcgtcggcga gcagggcgtc caggcgctcc tccgcgaccc gtgaggcctg cgcctgggcg
    14941 ttggcctccg ccagtgtctc ggcctgcacg tcgtgcgccg ggaacttcag caggcggatc
    15001 agcggcggca ggctgacgcc ctggacgacc agggtgccga tgacggtcgt gaaggtgagg
    15061 aacaggacga ggttgcgctc ggggaagggc gcgccgccgt gcacggtgag cggaatggag
    15121 aaggcgatcg ccagggagac cacgccccgc atcccggccc agccgatcac gaacggcgcc
    15181 ttccaggaga gggctccctc acgcgcgcgt acgcgggccg acagccgggg caggaaggtc
    15241 gccgggtaca cccacacgaa cctcgccacc gcaaccacca ggaagacggc gagggcgtac
    15301 caggcggcgt cgaggccctc gatctcgccc aggcccctga ggacgacggg caactggagt
    15361 ccgatgaggg cgaacacggc cgactccagg acgaacgcga ccatcttcca caccgcctcc
    15421 tcctggagcc gggtcgcgaa atcgacctcc cacgcgcggt gcccgaggta gagggccacg
    15481 acgaccaccg cgagcacacc cgaggcgtgc acctgctcgg cgaccgcgta ggcgacgaac
    15541 gggatcagca gggagagcgt gttctgcagc agcgcctccg tgaggtgggt gcgcagccag
    15601 tgcagcggca ccatcaggac cagtccgaca ccgacgccgc ccaccgccgc gatcaggaac
    15661 tccccgatgc cgcccgccca cgtcgtgccc tccccgacgg ccgccgcgag cgccaccttg
    15721 aaggcggtga tcgcggtggc gtcgttcacc agggactcgc cctggaggat cgtggtgatc
    15781 cgggagggca gccccacgcg gcgggcgacc gccgtggccg cgacggcgtc cggcggcgcc
    15841 acgaccgcgc cgagcaccag ggcggcggtc agcggcaggc cgggcacgat gaggtaggcc
    15901 gcgcatccga cgacgaaggt ggcgaacagg acgtagccca cggacagcag cgccacgggc
    15961 ctcgcctgcg cccgcaggtc caggtaggag ctgtcggtgg ccgccgtgta gagcagcggg
    16021 ggcagcagca ggggcaggac gacgtgcggg tcgagggtgt agtcgggcac gccgggcacg
    16081 tagctcaccg ccaggcccgc cgcgaccagc agcagcggca ccggtaccgg cacgcgccgg
    16141 cccgccgccg cgaccgcggc gctgcccgcc accagcaaca gcagcggcat cacgtccatc
    16201 gtcctcgccc gccctcggtt tccgcgcggt catccgcaca cccgtcgtaa cctggcaatc
    16261 atgaaacagt gcacgcacgc cgacgcgctg ccgcacccgg aacccgagcc gtgcggcgag
    16321 acctgcccgg agtgtctggc cgagggcacg gacccggtgc agttgaggct gtgcctgagc
    16381 tgcggtcatg tcggctgctg cgactcctcg ccgcggcagc acgcgacggc gcatcacaag
    16441 gagaccggtc atccggtgat gcggtccttc gagcccgggg agagctggcg ctggtgcttc
    16501 gtcgatcatg tactcgtgtg accccggccc gcgacggttc gaccgtctga cgtctgggta
    16561 cgtcaacccg gcgcgcgctc ttccgatttg ggcccgccga ccccctagcc actgtgcgtg
    16621 ttcatgtgtt tactatgagt gacagcacgg ggttggggtc tcggggacag gaaacttcgg
    16681 ggcgcgataa cgtcaccgct gaaccacgta tcgcgttgct ccgaggggcg tccctcggcc
    16741 ctgtaacgct tgtaccacct tggaggtgag ggtgtcccag atcgcaggcg agcccgcgac
    16801 ccaggacttc gtggaagtcc ggctgccggc cgcgggtgcc tacctgtcgg tgctgcgtac
    16861 ggcgacggcc ggcctcgcag cccgtttgga cttcaccctc gacgagatcg aggacctgcg
    16921 catcgcagtc gacgaggcct gcgcgatcct gctgcagcag gccgtgcccg gctcggtgct
    16981 cagttgcgtc ttccgtctcg tcgacgactc gctcgaggtc accgtctcgg cgccgaccac
    17041 ggacggccac gccccttcgc gggacacctt cgcgtggacg gtcctctccg ccctcgcggg
    17101 caaggtctcc tccgccgtgg acgaggacaa aaccgtttcg atcagcctct acaaacagcg
    17161 cggcgcggga cccgggccga cgtgagggac ggggacgggg acgggccggt gcgggacgaa
    17221 gagcgcggta cacgggagct gccggccgag ggcacacgtt ctccgaacga ggtgcggcgc
    17281 acggcggacg gcatcgacgg catccccgag caggcccggc cgcatccgga ggacgagacc
    17341 tcgcccgagg ccgtcgttcc gggcggcggg cagcggaccg gggggacccc cgtccggccc
    17401 gtccgagcgg aggcgcgggc tcgggaaagg gcgacgggcg ggacgatgag cgagcacgag
    17461 cgacacgccg acggccacgc gccgggcgca cggggcacgc agggcacacg gcacgacccg
    17521 caggaccgca gcggcgcgcg cctcctgttc gccgagctgc gcacgctggc gaaggacagc
    17581 ccggagtacg cggagctgcg caaccggctg gtccgcatgc acctgccgct cgtcgagcac
    17641 ctcgcgcgcc gcttccgcaa ccgcggcgag ccgctggacg acctcaccca ggtcgccacc
    17701 atcggactga tcaagtcggt ggaccgcttc gacccggacc gcggggtgga gttctccacg
    17761 tacgcgaccc ccacggtcgt cggcgagatc aagcggcact tccgggacaa gggctgggcg
    17821 gtgcgcgtcc cgcgccggct ccaggagctg cggctggccc tgacgacggc cacggcggaa
    17881 ctctcccagc tgcacggccg ctcccccacg gtgcacgagc tggcagagaa gctgtccatc
    17941 tcggaggagg aggtcctgga gggcctggag tcggccaacg cctactccac gctgtcgctg
    18001 gacgtcccgg acaccgacga cgagtccccg gcggtcgccg acaccctcgg cgccgaggac
    18061 gaggcactgg agggggtcga gtaccgggag tcgctcaagc cgctgctcga ggacctgccg
    18121 ccgcgggaga aacgcatcct gctgctgcgc ttcttcggca acatgaccca gtcgcagatc
    18181 gcgcaggagg tcgggatctc gcagatgcac gtgtcgcggc tgctggcccg cacgctcgcg
    18241 cagttgcggg agaagctgct ggtcgaggag tagccgcggc cggccgcccg gcgcgggcga
    18301 gggcttccgg ttacttccgg gcgttgcccg gtccccggat gccgagggcc agggtggtct
    18361 cgggattgat gagcatgtac agcgcggcga gcgccaggac accgagcacg gcgcccgcgg
    18421 ggacggcgag gctgtcggcc cccgccatgt tgtaggcgac gggcagcgcc aggatctgcg
    18481 tgatcacggc gggcccccgg ctccacccct tcaggcggag cagtccgcgg gcggcgagca
    18541 gcggcagcag ggcgaggacg atcagcgtga tgccgccggt gacggcggag gtccggtcgt
    18601 cggggtgtcc ggtgaggcct cccacgagca tccaggcgcc gccgacgacg agggccaggc
    18661 cctccaacgc ggcgatcgcc gccgcggcgg tcacccgggc ggggcggggc tctgcctcct
    18721 cggaggctgc ggaggcgggg tcgggggtct gctcactgct cacccctgca gggtagccgt
    18781 cggcgcggcc ccgcccgcgc ccgcccgggt gtcgggcccc tcacgcgccg gtgggcccgg
    18841 gtggcgatct tcactccggt ctgggccgag taccacccag taggtaccct gcacaccatg
    18901 cgtgcacttc tcgtggtcaa cccggcggca accaccacga gtgcgcgtac gcgcgacgtg
    18961 ctgatccacg cgctggcgag cgagatgaag ctggaggcgg tcaccaccga gtaccgcggc
    19021 cacgcccgcg acctcggccg tcaggcggcc cggagcgacg acatcgacct ggtggtggcc
    19081 ctcggcggcg acggcacggt gaacgaggtc gtcaacggcc tcctgcacgc gggccccgac
    19141 ccggagcacc tgcccggtct cgcggtcgtc cccggcggtt ccaccaacgt cttcgcccgc
    19201 gccctcggcc tgcccaacca cgcggtggag gcgaccgggg ccctgctgga cgccctgcgc
    19261 gagggcagcg aacgcaccgt cggcctcggt ctggcgtcgg gtacgccggg caccgaggac
    19321 gaggccgtcc cggcccgctg gttcaccttc aacgccggcc tgggcttcga cgccggtgtg
    19381 gtcggccgcg tcgagcagca ccgcgagcgc ggcaggaagt cgacgcacgc cctctacgtc
    19441 cgtcaggtgg tgcgccagct catcggcgag ccgcaccgcc gcagcggcac gatcacgctg
    19501 gagcgggagg gcgaggaccc ggtcaccgac ctggtgctgt ccatagtctc gaacacctgc
    19561 ccctggacgt tcctcggcaa ccgcccgatc tacgcctccc ccgaggcgtc gttcgacacc
    19621 gcgctcgacg tcttcggcct cagccggctg tcgacggccg cggttgcccg gtatggcacc
    19681 cagttgctca cttcgtcccc cgagcgcggg ccgcgaggcc gacacgcggt ctccctgcac
    19741 gatctgaccg acttcacctt gcattcgaag gtgcctctgc cccttcagat ggacggtgac
    19801 cacctgggcc tgcggaccag cgtgacgttc acaggcgtac gccgtgcact gcgtgtgatt
    19861 gtgtgagcag aaggggcgaa agtcctttca ctcgaacgtt tagaccaggg tccaccccat
    19921 ggaagtacgg ctgtgaccta gtcgacaccg aagaatcaaa aaaaactttc cggaaggggt
    19981 tgtatccgcc gccgaggttt gcgagtctct tcttggcgat cgggacagcc cgcaagaccg
    20041 gcatccacag atcaccggaa cccctcttca aaccacagga ccacgccagg gaacctggcg
    20101 gtaggccctt cccttgttga gggattcgtg aaagcgttca cattcacaag catccgagca
    20161 tgtaatacca aggagaggta gcagccatgg actggcgtca ccgcgccgtt tgccgcgagg
    20221 aagaccccga gctcttcttc cccatcggca acaccggtcc cgcgctgctg cagatcgagg
    20281 aagccaaggc cgtctgccgt cgctgccccg tcatggagca gtgcctgcag tgggcgctcg
    20341 agtccggcca ggactccggc gtctggggtg gtctcagcga ggacgagcgt cgcgcaatga
    20401 agcgccgtgc cgcccgcaac cgggcccgtc aggcctccgc ctgacaaccc acccctactg
    20461 acagcctcag cttggcggcg cgtacagcga gtacgcatcc cccgctcccg agccgcagcg
    20521 cgcagtaccc ccgatgcgca tcggacgatg tagcgcacga gcacaggcct cggaccttca
    20581 caggtccggg gctttttgct gtgccgggaa ccgcggtcct cggctccggc cacgtccgtc
    20641 ggcccgccga ccgggccgct cctcgactcc tcgacccctc gactacttct cggcgggcac
    20701 cgggatgtcg aggatcaccc gggtgccgcg cccggaggcc gggaccatgt cgaaggtgcc
    20761 gctcagctcg ccctcgacca gggtgcgcac gatctgcagc ccgaggttgc cggagcggtg
    20821 cgggtcgaag tcctcgggca ggccgacgcc gtcgtcctgg acggtgacca ggagccgggc
    20881 ctccttggtg gtgccgccgc ggaccgccga gacctcgacc gtgccggtgt cgctgtcccg
    20941 gaagccgtgc tccagggcgt tctgcagcac ctcggtgagc accatggaca gcggggtggc
    21001 gacctcggcg tcgaggatgc cgaagcggcc ggtgcgccgg ccggtgaccc tgcccgggga
    21061 gatctcggcc accatcgcca gcacgcggtc ggcgatctcg tcgaactcca cgcgctcgtc
    21121 caggttctgc gagagcgtct cgtgcacgat cgcgatggag c
//
