LOCUS       NZ_CFVJ01000025         6791 bp    DNA     linear   CON 04-AUG-2024
DEFINITION  Streptococcus pneumoniae strain 17F/2, whole genome shotgun
            sequence.
ACCESSION   NZ_CFVJ01000025
VERSION     NZ_CFVJ01000025.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001326475.1-RS_2024_08_04
            Annotation Date                   :: 08/04/2024 01:25:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,120
            CDSs (total)                      :: 2,087
            Genes (coding)                    :: 1,951
            CDSs (with protein)               :: 1,951
            Genes (RNA)                       :: 33
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 27
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 59 of 136
            Pseudo Genes (incomplete)         :: 74 of 136
            Pseudo Genes (internal stop)      :: 39 of 136
            Pseudo Genes (multiple problems)  :: 30 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:58:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 19904
            Orig. end                         :: 26695
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CFVJ01000025.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..6791
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..6791
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..6791
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5204](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5204
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(995..1123)
                     /gene="blpC"
                     /locus_tag="AP598_RS08685"
                     /old_locus_tag="ERS012477_01700"
     CDS             complement(995..1123)
                     /codon_start=1
                     /gene="blpC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358815.1"
                     /locus_tag="AP598_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01700"
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="WP_000358815.1"
                     /transl_table=11
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDLLYNINRYAHYIT"
     gene            complement(1180..2550)
                     /locus_tag="AP598_RS08690"
                     /old_locus_tag="ERS012477_01701"
                     /pseudo=""
     CDS             complement(1180..2550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /locus_tag="AP598_RS08690"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01701"
                     /product="bacteriocin secretion accessory protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKEI
                     TVTSQGEITPTSVITSIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTALAT
                     QLQRLEKQKEGLGILKQSLEKATDLFSGEDEFGYHNTFMNFTKQSHDIELGISKTNTEV
                     SNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTGNPHQSILNRYLIAS
                     QEQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVLRTQFL
                     QTASQQQLTVENQLTELTELKVQLDQATQRLGNNTLTAPSKGIVHLNSEF"
     gene            complement(2561..3472)
                     /locus_tag="AP598_RS12745"
                     /old_locus_tag="ERS012477_01702"
     CDS             complement(2561..3472)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826860.1"
                     /locus_tag="AP598_RS12745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01702"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_001827226.1"
                     /transl_table=11
                     /translation="MSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLN
                     EVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGV
                     SGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHINYLPQQAYIFNGSILEN
                     LTLGGNHMISQEDILKACEVAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALL
                     TKSPVLILDEATSGLDVLTEKKVIDNLMSLTNKTILFVAHRLSIAERTNRVIVLDQGKI
                     IEVGSHQELMQAQGFYHHLFNK"
     gene            complement(3462..4187)
                     /locus_tag="AP598_RS12750"
                     /old_locus_tag="ERS012477_01703"
     CDS             complement(3462..4187)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="AP598_RS12750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01703"
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /protein_id="WP_167750760.1"
                     /transl_table=11
                     /translation="MVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQV
                     MSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALA
                     STILSLFLDVSILILVEGVLLAQNPNLFLLSLISIPIYMFIIFSFMKPFEKMNHDVMQS
                     NSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGN
                     KISSEYPYPMVWRSISHVE"
     gene            complement(4132..4719)
                     /locus_tag="AP598_RS12755"
                     /old_locus_tag="ERS012477_01704"
     CDS             complement(4132..4719)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855030.1"
                     /locus_tag="AP598_RS12755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01704"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_000205166.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-43, bitscore:
                     138.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTN
                     KEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQTK
                     KDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPSSDF
                     QTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG"
     gene            5001..5204
                     /locus_tag="AP598_RS08710"
                     /old_locus_tag="ERS012477_01705"
     CDS             5001..5204
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093272.1"
                     /locus_tag="AP598_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01705"
                     /product="bacteriocin class II family protein"
                     /protein_id="WP_001093262.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3e-11, bitscore:
                     34.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMEQFSVMDNEMLDRIEGGIFGVDDALFWAGLGYVAGSIVD
                     TAIDDFTNQCRKNPHQWFCVRV"
     misc_feature    5275..5291
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.78"
                     /tool="antismash"
     gene            5522..5725
                     /locus_tag="AP598_RS08715"
                     /old_locus_tag="ERS012477_01706"
     CDS             5522..5725
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411016.1"
                     /locus_tag="AP598_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01706"
                     /product="hypothetical protein"
                     /protein_id="WP_000411016.1"
                     /transl_table=11
                     /translation="MEKIDYITLNEVELETISGGDDCFIGDIGCIGWGLLKSIGGMIKP
                     APYVPPVCIPKSSWNPAPPVPC"
ORIGIN
        1 aaatggttgg actacgattt tactagcttg agaaaggaga ttctcgataa agcctttcaa
       61 aagtccctga ctcagattaa ctggataatg ggtggctact atctagtcat ggaaagtctg
      121 tctttttttg aatatgaaca aagtattcaa tcaaagactg ttcgccatct catcctagtc
      181 ttttacctac tcttttttat gggggttatc aagaaattgg atacctattt gaaggaaaaa
      241 ctctatgaga gattggaaca agagcaggcc ctgcgctata gagatatgga acgctatagt
      301 cggcatatag aggagcttta caaggaagta cggagctttc gtcatgatta taccaacctc
      361 ttgactagct tacgtctggg cattgaagag gaggatatgg agcagataaa agaggtctat
      421 ggctccgtct taaaggattc cagtcagaaa ttgcagaaca ataaatatga cctgggcaga
      481 ttggtaaata ttcgtgataa agccctcaaa agtcttctag cagggaaatt tttaaaagcc
      541 agagataaga acattgtctt taatgtcgaa gttcctgagg agattcaggt cgaggggatg
      601 agtctacttg attttctaac cattgtgtct atcctttgtg acaatgctat tgaagccagt
      661 gtggaaggta gtcaacctca tgtttcaatc gcctttttaa aaaatggagc acaggagacc
      721 tttatcatcg aaaactccat caaagaagag ggcatcgata tttctgaaat cttctccttt
      781 ggagccagtt ctaaagggga ggagagagga gttggtctct ataccgtcat gaagattgtg
      841 gaaagccatc ctaataccag tctaaatacc acctgtcaaa atcaagtctt tcgtcaggta
      901 cttactgtga tacatacaga atgatgaaaa ataagaccga gagtacttgt ttctcggtct
      961 tattttttta tagttgtatt ggatgatgaa gttcttatgt gatgtaatga gcatatctat
     1021 taatgttata taataaatct tcccacaatc ctccacctgt aatttggttg agttcggtag
     1081 ttgttagttc ttgaaatgaa gttaggtttt gtttcttatc catgttatga ttctcctttt
     1141 tgataagata ataaatagtt atagagtgtt atctgaaaat taatcagaat gggttaaaat
     1201 tttatctttg aaataatcaa aatatgtttt ctttgcagtt acactagtga cgcgaccttg
     1261 taagccatat tggatgagtt tactatcctc attagatagt tttgcaagag cggttaattt
     1321 aaagagattg ccttgctctg ttctggtagg agtttgatca attgtctgaa gttggccgat
     1381 gatggtaatg ccgtgatttc caatcttctc cagttttaat cttacagttt gtcctttatc
     1441 tagtagaggt agatagtcag aagctacgta gtaagtgatt agtacttctc ttgtatctgt
     1501 gatgataggg aatatttgag caatttctgt accagttgga attctatttt taccttaaaa
     1561 ttcgctgttc agatgaacga tacctttact tggagcggtt aaggtattgt ttcctaagcg
     1621 ctgcgttgct tgatctagtt gtacttttaa ttctgttaat tctgttaatt gattctccac
     1681 ggttagttgt tgctgagaag ctgtttgtaa aaattgagtg cggagtactt caattttggt
     1741 tgctaaacta ttatcataag ttgctacact tccgatacca gcttgctgaa ttttgaggct
     1801 tgcgatagat gattcaagac ctgcaatact ttgattaatt tgagataaaa atggctcctc
     1861 tgccgttcct tgtgtttgtt cttgagaggc tataagataa cgatttaaaa ttgactggtg
     1921 cggattgcca gttggtaagc gagctctgtt atttatgata gcatctctca gctcttgata
     1981 ttctccaatt tgttgttgaa cttttgtaat ttcttgttcg atggctgatg aactgctatt
     2041 ggcaagattg gcttgatttg aaacttcagt gttagtcttt gagataccga gttcaatatc
     2101 atgggattgt ttagtaaaat tcataaaggt attatggtag ccaaactcat cctcgccaga
     2161 aaaaagatca gtcgcttttt ctaagctttg tttcaaaatt ccaagtcctt ctttttgctt
     2221 ctcaagtctt tgtaattgag ttgctaaggc agttttctga ctctcttcca ttgtttcaga
     2281 gtatttgatg agtaagtcac ctttctcaac tacttgattt gccactaaat gattagctag
     2341 gataggatta tcactggtcg actgaataga tgtaatgaca cttgtagggg tgatttcccc
     2401 ttgcgatgta acagtaattt cttttgtggc aacaagggag aaaatcaaga tgaaagtaaa
     2461 cagtaatgac agaggtatga ttaatactgt cgcatagtta tggtaacgtc tctgataaaa
     2521 ctcgacactt ctaaaaagat taggattcat gacattctcc ttatttattg aatagatgat
     2581 ggtagaatcc ttgcgcttgc attaactctt ggtgactacc aacttcaatg attttcccct
     2641 ggtcaagaac aatgacacgg ttagttcgtt cggctatact gagacgatgg gctacaaaga
     2701 gaatggtttt attagttagg gacataagat tatctataac ctttttctca gtcaagacat
     2761 caagaccgct agtagcttca tctagtatta aaacaggaga tttagttaaa agagcacgag
     2821 cgagagcgat tcgttgcttc tgtcctcctg atagaccagc tccatcagag agctgagttt
     2881 gatagcccat aggcattctt tcaatgtctt gacggatttc agctacttca caagctttta
     2941 gaatatcttc ttgactaatc atatgattac cgcccaaggt taagttttcc aaaatagagc
     3001 cattaaagat ataggcttgt tggggtaggt aattaatatg acggcgcaag acttttttat
     3061 caatgttttt aatatcctga tgattgatgg aaatatgccc tttgtagggt tcaaagaaat
     3121 tgacaatcat tttggctaaa gttgttttac cagaaccact aactccaact aggctaacct
     3181 tatctccttg tttaatcgtg agattaatat ctgttaaggt atctcgtcca aaaccatact
     3241 tataagaaag gtcatcaaat tcaatatcgc ccatcaaaaa atgtgaatga acagggtttt
     3301 cttgaacttg aaattcagat tcgactagat agacttcgtt caaacggtta ttagcgacct
     3361 tcgcagattg gagtttggtt tggaggttga taatattttc cataggagtt gtaaagtaag
     3421 aaagaagtgt gttaaaggta atcagctgac cgatagaaat tttactcgac atgactaatt
     3481 gagcgccaaa ccataggata aggatattca gaactaattt tgttcccctg ctttaaactc
     3541 gtttgtaaaa tagaatattt actgagctta aaggattttt ccaaataatc tacaaattcg
     3601 ctgtctatat tttgatagcg attttcttca ctcgtgagcg actttatagt ttcaatcccg
     3661 ttgatatctt cgataatggc agagctaacc atagaattac tttgcatgac atcatggttc
     3721 attttttcga aaggcttcat aaaagaaaag atgatgaaca tgtatatagg aatggaaata
     3781 agagaaagaa ggaagagatt agggttttgt gccagcaaga ctccctctac aagaatcaga
     3841 atagaaacat ccagaaaaag agaaagaatg gtagaagcca aggcatctat aatagagtta
     3901 gcatctgtga accgtgaaat gatttctcct gtacgacgtg tcgcaaagaa agacatggga
     3961 agttcaaaaa tatggcgaat ataggataaa atcacatcaa tacttaatct ctgactcaga
     4021 acggttagga gataatctct ggagaagctc atgacttgtt ggaggatata ggtgataacc
     4081 agaccaactg agatgattcc taaagttgat ttcatctgat ttggaatgta ttcatccaag
     4141 attccttgga gatagtaaga accacctata ttgataatag tgaccaataa gcttgagaga
     4201 acaatgtaag caatgagaga tttttgtttg aaaatcagag gaaggaagct tgcttagtag
     4261 accattcttt ttatctttat ggggttgata gctgggtttg gtagctagaa aaatagctac
     4321 tccagtccat tcatagaaaa agcgttcttt tgacatttta gtgattttta cagaagggtc
     4381 aggatcacca ataatcagat agtctttctt tgtttgatag acaacatagt aatgttggag
     4441 ttttccttct ttgttaacgt gaacgataaa tggatagggg acatcactca tgtcaaagag
     4501 cgttttatct gcttgaacag gtcttgtttc aaagcccatt tcatcagcgg cttttacaat
     4561 gccaagagca gtcgtccctt ctttattggt ctttgcaagt tctctcaagt gagctagaga
     4621 aaaatctgaa ccatagaatt tagcaatcga ggctaaggca gcgacaccac agtctctcgc
     4681 atctatttga ggaacaaatg tacgtttata agaagtcatt ggcaattcct ttcatatagt
     4741 ggataggtct attatgtcat aaaactaagt tcatatttta tgaaatcttg aatagtcatt
     4801 aaaacttcct gaatggtaaa aaagtgatta gaaattattt tttttaaaca tttagaggtg
     4861 gcttgaaata aaaaagctaa ttcaagacgt ttcgatgaca attcaagatc tggatgaaaa
     4921 attttaaaaa acgatgatat actaaactta tcaaagttac aacaagacaa aaataaaaaa
     4981 agaaaaaagg agtatttgtc atgaatacaa aaatgatgga acaattttct gttatggata
     5041 atgaaatgct tgataggata gagggaggaa tatttggagt tgacgatgct ttgttttggg
     5101 cagggttagg ctatgttgca ggtagcattg ttgatacagc aattgatgat tttacgaatc
     5161 aatgccggaa aaatcctcat cagtggttct gtgttcgtgt atagatatag tagtgttgta
     5221 ttgtataaga atttatataa cttaatgacc tatgcagtga tagaaactat tcttttgcaa
     5281 acgagtcgct tattctgtta taagtttacg tgctcctagt cacagttctt gtgcttgata
     5341 gaaagaatga cacctataaa aatgcgagat attggctata tcactcactt attcacctcc
     5401 ccgtgatttg tagtagtgat aggttttctc actattatta taaacattat aaaataaaga
     5461 gtacaacact ttttcattct gtgttgtgcc ttgagtaaaa cgaaaggaat gaattataac
     5521 aatggaaaaa attgattata ttactttgaa tgaagtagaa ttagagacga ttagtggtgg
     5581 agatgactgt tttattggag atatcggatg tatcggctgg gggcttttga agagtatcgg
     5641 agggatgata aaacctgctc catatgttcc tccagtatgc attccaaaaa gttcgtggaa
     5701 tcctgcacct ccagttccat gttaaaaagt tattgtaaac ttatataaaa aatgaataat
     5761 cgacttgttc gctattttgt tgaatcttcg caactataat atacatgtgt tgttcaggat
     5821 tattttagct tattgcaaga gtcgaaaact agaaactaat ggctggttgg aacgttaaaa
     5881 attcactttc taaccagcta atactgcttc aaataatttc tgaacaagtc taataaataa
     5941 aacgaataag atagattatt aacacagtct tgttcgtttt ttctcatata ttatttaatt
     6001 aataatatta taaaattgga aagcagtagg gatgggaagt actaccacag atttattatt
     6061 aattttatca gtattgtttg aaatccaaaa aaagtatgtt aagctatatt tatttggttc
     6121 tttagtttga ttgttgttga gtataactat ttttgtatag atgaaaatct tgttattgtt
     6181 caagatgttt tgatgaccat tcatgatttg agtaatccaa ggtcaaaatg agtgctatac
     6241 tagcagtgta aagattcttg ttcaactaag ataaatcaca catttaggag gaaattttat
     6301 gaagaaaaaa atacttatca ttttcatctt gtatctaatc atgtccatct ttctttatcc
     6361 gcttagggaa agtatttggt atcagctatt ttataccata gcctatgtga ttgcagttat
     6421 gatctatttt gctttaacta aaaagaaagg agcaaagaaa tgaaaacttt tcttgctaaa
     6481 aaacggaaca tcttcctttc atttggggat tgaagtatta taaaaagtag agcttaataa
     6541 agtataaagg ggtaagtgtt tttgaaatac ttaccctttt ataatagatt ccctgcgaaa
     6601 caaaatatgg tatagtatag tagattgaaa ctagaatagt acgcctctac ttctaaaaca
     6661 ttgttagaaa tcgatttgac tgtcctgatc gatttatcct gttcttattt cattttacta
     6721 tagttctatg aattatgaag caagtaaata actaactgat gcacgattta agcgtcttgt
     6781 tggtgttcag c
//
