LOCUS       NZ_CFVJ01000022        21757 bp    DNA     linear   CON 04-AUG-2024
DEFINITION  Streptococcus pneumoniae strain 17F/2, whole genome shotgun
            sequence.
ACCESSION   NZ_CFVJ01000022
VERSION     NZ_CFVJ01000022.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001326475.1-RS_2024_08_04
            Annotation Date                   :: 08/04/2024 01:25:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,120
            CDSs (total)                      :: 2,087
            Genes (coding)                    :: 1,951
            CDSs (with protein)               :: 1,951
            Genes (RNA)                       :: 33
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 27
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 59 of 136
            Pseudo Genes (incomplete)         :: 74 of 136
            Pseudo Genes (internal stop)      :: 39 of 136
            Pseudo Genes (multiple problems)  :: 30 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:58:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 21757
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CFVJ01000022.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     cand_cluster    1..21757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21757
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[584:1757](+)"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      585..1757
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     gene            <1..138
                     /locus_tag="AP598_RS11935"
                     /pseudo=""
     CDS             <1..138
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="AP598_RS11935"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RSKVENIFAKVKTFKMISTTYRNHRKRFGLRMNLIAGIINHELGF
                     "
     gene            206..454
                     /locus_tag="AP598_RS08135"
                     /old_locus_tag="ERS012477_01596"
     CDS             206..454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /locus_tag="AP598_RS08135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01596"
                     /product="hypothetical protein"
                     /protein_id="WP_001818278.1"
                     /transl_table=11
                     /translation="MVSSSGSEFQSGWQEHQLIAEKVSKTLDKTFDKDVREIPTSQFYQ
                     KFVDEMGRTYSGNLILQELITVNGAYKATYIGELSSN"
     gene            585..1757
                     /locus_tag="AP598_RS08140"
                     /old_locus_tag="ERS012477_01597"
     CDS             585..1757
                     /EC_number="2.3.3.10"
                     /GO_function="GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043: hydroxymethylglutaryl-CoA synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /locus_tag="AP598_RS08140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01597"
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="WP_000151960.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 8.7e-10,
                     bitscore: 29.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIA
                     PLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARS
                     FEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLIT
                     QNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQL
                     TLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGNIYTGS
                     LFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRT
                     ALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            1757..3031
                     /locus_tag="AP598_RS08145"
                     /old_locus_tag="ERS012477_01598"
     CDS             1757..3031
                     /EC_number="1.1.1.88"
                     /GO_function="GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0015936 - coenzyme A metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1187: hydroxymethylglutaryl-CoA reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /locus_tag="AP598_RS08145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01598"
                     /product="hydroxymethylglutaryl-CoA reductase, degradative"
                     /protein_id="WP_000704379.1"
                     /transl_table=11
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVA
                     DQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQ
                     VHQRQMIGQVALYQIANPKLAQEKIASKKAELLELANQAYPSIVKRGGGASDLHVEQIK
                     GEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTAS
                     CRMAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWR
                     AIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVALSHD
                     LLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAP
                     LVERLISDKTFNLETAQRYLENLRS"
     gene            complement(3066..4031)
                     /locus_tag="AP598_RS08150"
                     /old_locus_tag="ERS012477_01599"
     CDS             complement(3066..4031)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /locus_tag="AP598_RS08150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01599"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_000226017.1"
                     /transl_table=11
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSVKTIQKVNEAMRELG
                     YKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDSEK
                     EREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAGGVL
                     AAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKEMEIK
                     NILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQLATIK
                     QPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(4012..5466)
                     /locus_tag="AP598_RS08155"
                     /old_locus_tag="ERS012477_01600"
     CDS             complement(4012..5466)
                     /EC_number="3.2.1.26"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004564 - beta-fructofuranosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /locus_tag="AP598_RS08155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01600"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="WP_000455301.1"
                     /transl_table=11
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGLL
                     NDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLVHFKETGIKVLPDTPLDSHG
                     AYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPADSTD
                     HFRDPQIFNFKGQYYAVVGGQDLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRTAYMM
                     ECPNLVFVEEQPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQLQNMD
                     YGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDCFDHQGTFSLIKELTIKDDKLYQYP
                     VAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSINFDLVNGQ
                     VTVDRSHAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVFSGRVFPHA
                     DQNGILIKSGNPTGTYYELDYGRKTN"
     misc_feature    complement(5543..5558)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.4"
                     /tool="antismash"
     gene            5843..7726
                     /locus_tag="AP598_RS08165"
                     /old_locus_tag="ERS012477_01601"
     CDS             5843..7726
                     /EC_number="2.7.1.211"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /locus_tag="AP598_RS08165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01601"
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="WP_050090540.1"
                     /transl_table=11
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEVI
                     ENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEAAKQGNWFQRA
                     IRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPGLVV
                     WSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGSVLPA
                     FIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYILIATK
                     AILSLPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAAMTAQGA
                     ATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAGAIGGGLA
                     SILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYEDEVDATAA
                     AKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQGIAVKPSQGV
                     VYAPADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKVAQGNKVKAGD
                     VLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVSKGDAVIEVKI"
     gene            7875..8762
                     /gene="scrK"
                     /locus_tag="AP598_RS08170"
                     /old_locus_tag="ERS012477_01602"
     CDS             7875..8762
                     /EC_number="2.7.1.4"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008865 - fructokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scrK"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /locus_tag="AP598_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01602"
                     /product="fructokinase ScrK"
                     /protein_id="WP_000164310.1"
                     /transl_table=11
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKTI
                     EFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPMYF
                     TTDVNSSAYGEVVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHYYVA
                     RHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGENIELNNPVWDVQAYYIAQAA
                     VNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAVAGNGS
                     ATLGNFVLAKEVSK"
     gene            complement(9082..9699)
                     /locus_tag="AP598_RS08175"
                     /old_locus_tag="ERS012477_01603"
     CDS             complement(9082..9699)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /locus_tag="AP598_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01603"
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="WP_000076185.1"
                     /transl_table=11
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQSK
                     ETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGIVI
                     GCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADFLCM
                     LAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(10114..>10327)
                     /locus_tag="AP598_RS08180"
                     /pseudo=""
     CDS             complement(10114..>10327)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /locus_tag="AP598_RS08180"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS30 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="YIYYAHHYRI"
     gene            complement(10695..10886)
                     /locus_tag="AP598_RS12550"
     CDS             complement(10695..10886)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AP598_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_057485815.1"
                     /transl_table=11
                     /translation="MKSKEQTRKLAVGCSKYSFEVADRTDVVSSKHSFEVVDRTDEVSN
                     YIYGKAELTWFEEIFEEY"
     gene            11009..11902
                     /locus_tag="AP598_RS08190"
                     /old_locus_tag="ERS012477_01604"
     CDS             11009..11902
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /locus_tag="AP598_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01604"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000895292.1"
                     /transl_table=11
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIFH
                     SILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDAKE
                     VKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLDPVN
                     TELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQYGKT
                     RLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIATFDQQ
                     APTIDEIFKLESGVEV"
     gene            11899..13098
                     /locus_tag="AP598_RS08195"
                     /old_locus_tag="ERS012477_01605"
     CDS             11899..13098
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /locus_tag="AP598_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01605"
                     /product="ABC transporter permease"
                     /protein_id="WP_001245381.1"
                     /transl_table=11
                     /translation="MRNMWVVIKETYLRHVKSWSFFFMVISPFLFLGISVGIGHIQGSS
                     MAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSVLK
                     AVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEAKEN
                     KKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYARMMA
                     LFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILVHLGDAISLNTLLFILISLFMYVV
                     LAAFLGSMVSRPEDSGKALSPLMILIMGSFFGVTALGAAGDNLLLKIGSYIPFISTFFM
                     PFRTINGYAEGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTFKRALSYK
                     "
     gene            complement(13511..14278)
                     /locus_tag="AP598_RS08200"
                     /old_locus_tag="ERS012477_01606"
     CDS             complement(13511..14278)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /locus_tag="AP598_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01606"
                     /product="hypothetical protein"
                     /protein_id="WP_050098609.1"
                     /transl_table=11
                     /translation="MFWNLVHYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQE
                     SQATMLLFLATVFGGLMLTLAISTIFLIIKRFKGSVYDRQGYLTLTLPISEHHIITAKL
                     IGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLNTIS
                     GILCIYLAISIGQLFNEYRTALAVAAYIGIQIVVGFIEVFFNTSTNFYINSLAGFNDNF
                     YMGASIGIVEELIFIAIFYLGTYYILRNKVNLL"
     misc_feature    complement(14237..14252)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            complement(14295..14990)
                     /locus_tag="AP598_RS08205"
                     /old_locus_tag="ERS012477_01607"
     CDS             complement(14295..14990)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /locus_tag="AP598_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01607"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000054201.1"
                     /transl_table=11
                     /translation="MSLLAFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTTL
                     IKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYKDF
                     NLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPAARA
                     YILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESGESID
                     QLFRQEFKA"
     gene            complement(14995..15360)
                     /locus_tag="AP598_RS08210"
                     /old_locus_tag="ERS012477_01608"
     CDS             complement(14995..15360)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /locus_tag="AP598_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01608"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_000119153.1"
                     /transl_table=11
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEAG
                     VNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTHFG
                     YEKEELPGVVSDYIKGV"
     gene            15500..15973
                     /gene="nrdR"
                     /locus_tag="AP598_RS08215"
                     /old_locus_tag="ERS012477_01609"
     CDS             15500..15973
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0140110 - transcription regulator activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nrdR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /locus_tag="AP598_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01609"
                     /product="transcriptional regulator NrdR"
                     /protein_id="WP_001203672.1"
                     /transl_table=11
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVE
                     ERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQ
                     SEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            15974..17143
                     /locus_tag="AP598_RS08220"
                     /old_locus_tag="ERS012477_01610"
     CDS             15974..17143
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /locus_tag="AP598_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01610"
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="WP_000802400.1"
                     /transl_table=11
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISFW
                     DNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQDFL
                     GHPVYRRLLEKKIGDVAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKKVAN
                     DFDLEHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVISTKR
                     MREKIAQKPVSSDFSLKEATIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQQMAGL
                     GLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEEAVLRIRDRGQKAKT
                     QKQNQTAPEKTNVPKWSNPEYKNETSEETRLELERKKQELLARLEKGGD"
     gene            17144..18040
                     /gene="dnaI"
                     /locus_tag="AP598_RS08225"
                     /old_locus_tag="ERS012477_01611"
     CDS             17144..18040
                     /codon_start=1
                     /gene="dnaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /locus_tag="AP598_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01611"
                     /product="primosomal protein DnaI"
                     /protein_id="WP_000446534.1"
                     /transl_table=11
                     /translation="MESVGDVLKRQPSRFYYQDLVQKIMKDPDVAAFIQQESLTPKELN
                     RSISKFNQYITERDKFLRGDTDYIAKGYKPILVKNHGYADVSYEETPELIAAEKEAAIK
                     NRLKLINLPASLKKASLAQVDLDDLGRLPVFEKLLAFVEQYPAIRKGLYLYGDFGVGKS
                     FMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAISDGNVKTLVDEIKLSEVLILDDIGA
                     EQSTVWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKVKHGNDETWEARRVME
                     RIRYLAEETRLEGVNRR"
     gene            18037..18750
                     /locus_tag="AP598_RS08230"
                     /old_locus_tag="ERS012477_01612"
     CDS             18037..18750
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /locus_tag="AP598_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01612"
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="WP_000140849.1"
                     /sec_met_domain="PF00881 (E-value: 1.8e-23, bitscore: 74.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQS
                     YSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVEGL
                     LISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMALGVP
                     NQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQFGQA
                     EPSSTRKNLEQKKLL"
     gene            18764..20074
                     /gene="der"
                     /locus_tag="AP598_RS08235"
                     /old_locus_tag="ERS012477_01613"
     CDS             18764..20074
                     /EC_number="3.6.5.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="der"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /locus_tag="AP598_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01613"
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="WP_001207696.1"
                     /transl_table=11
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYAT
                     GEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEYVA
                     RKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIVENL
                     PNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDTDG
                     QEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGF
                     AHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQRLHKLP
                     EMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVIFV
                     NEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     misc_feature    20129..20140
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.14"
                     /tool="antismash"
     gene            20165..20500
                     /locus_tag="AP598_RS08240"
                     /old_locus_tag="ERS012477_01614"
     CDS             20165..20500
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /locus_tag="AP598_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01614"
                     /product="hypothetical protein"
                     /protein_id="WP_000400493.1"
                     /transl_table=11
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWFYIPFYS
                     LFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQELG
                     KSKGGRH"
     gene            20641..20991
                     /locus_tag="AP598_RS08245"
                     /old_locus_tag="ERS012477_01615"
     CDS             20641..20991
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400504.1"
                     /locus_tag="AP598_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01615"
                     /product="hypothetical protein"
                     /protein_id="WP_000400506.1"
                     /transl_table=11
                     /translation="MEHLFKMIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYITLYA
                     LFSLAWTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASDWLAYVFFKKMLDLRRELG
                     KSKGVHKGRCRN"
     misc_feature    21389..21403
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.53"
                     /tool="antismash"
ORIGIN
        1 agaagcaagg ttgagaacat ctttgccaaa gtaaaaacgt ttaaaatgat ttcgacaacc
       61 tatcgaaatc atcgtaaacg cttcggatta cgaatgaatt tgattgctgg cattatcaat
      121 catgaactag gattctagtt ttgcaggaag tctactactt tccttattgt ctgtaaatct
      181 actgaccttg ttgtttatcc cagtcatggt ttctagttcg ggctcagagt ttcaaagtgg
      241 atggcaagag catcaattga ttgctgagaa ggttagtaaa acacttgata agacatttga
      301 taaggatgtc agagaaattc cgaccagtca gttttatcaa aaatttgtag atgagatggg
      361 aaggacttac tcaggaaatt tgatcctcca ggagctgata actgtgaatg gagcttataa
      421 agctacttat atcggtgaac tctctagcaa ctaatcattc tttaaaatga tgaccaataa
      481 gaggcttgat ttggtgaatc aagtcttttt tctctctttt actgccattt gtgataaaat
      541 agtatagaac gattttttac atgaatgata aaacagaggt aaatatgaca atcggtattg
      601 ataagattgg ttttgcgacc agtcaatatg tcttgaaatt acaagactta gcagaagcga
      661 ggggaattga ccctgaaaaa ttaagtaaag gactcttact caaggaattg agtattgcgc
      721 ccctaactga ggacattgtg accttggcgg ccagtgctag tgactctatt ttaactgagc
      781 aagaaagaca agaagttgac atggtcattg tggctaccga gtcaggaatt gaccagagta
      841 aggctgcggc cgtctttgtg catggcttgc tgggcatcca gccctttgct cgtagtttcg
      901 agattaaaga agcctgttat ggagcgactg ctgcccttca ttatgccaaa ttgcatgtgg
      961 aaaattctcc ggagtccaag gtcttggtca ttgccagtga tattgccaaa tacggtattg
     1021 aaactccagg agaaccaact caaggtgctg gaagtgtagc tatgttgatt acacaaaatc
     1081 cacgcatgat ggcctttaat aatgacaatg tagctcagac ccgtgacatc atggatttct
     1141 ggcgaccaaa ttactcgaca actccttatg taaatggtgt ttattctacc caacaatact
     1201 tggatagttt gaaaacgact tggcttgaat atcaaaaacg ctaccagctt actctggatg
     1261 attttgcggc tgtttgtttc cacttgcctt atcctaaatt agcgctaaaa ggcttgaaaa
     1321 aaatcatgga taagagcctg cctcaagaga aaaaagacct cttacaaaag cattttgacc
     1381 agtctattct ctacagtcaa aaggtgggga atatctacac aggttcactt ttccttggac
     1441 ttttgtctct cttggaaaat acagatagct tgaaagctgg ggataaaatc gccctttata
     1501 gttacggaag tggagctgtg gctgagttct tcagtggtga attggttgaa ggatatgaag
     1561 cttatttgga taaagaccgc ttgaacaagc tcaaccaacg aactgcccta tccgttgcag
     1621 actatgaaaa ggtctttttt gaggaagtaa acttggatga aacaaactct gcccagtttg
     1681 ctggctatga aaatcaagat tttgccttgg ttgaaattct tgaccaccaa cgccgttata
     1741 gcaaggttga aaaataatga agataagttg gaatggattt tctaaaaaat cataccaaga
     1801 gcgcctcgag ctgctaaaag ctcaggcgct ccttagtcct gagagacaag ctagtctgga
     1861 gaaggatgaa cagatgagtg tgactgtggc agaccagctg agtgagaatg tggtgggaac
     1921 tttttctctg ccttattcgc tggttccgga ggtacttgtc aacggtcagg aatacaccgt
     1981 tccctatgtg acagaagaac cctctgtggt tgcggcggcc agctatgcca gcaaaatcat
     2041 caagcgtgca ggtggtttta ctgcacaagt ccatcagcgc cagatgattg ggcaggtagc
     2101 cctttatcaa attgctaatc ctaaactagc gcaagagaag attgccagca agaaagcgga
     2161 gctcttggag cttgccaatc aagcctatcc ttctatcgtt aaacgtgggg gtggggcgag
     2221 tgacctgcat gtcgagcaga taaaaggtga accagacttt ctcgttgttt atattcatgt
     2281 tgatacccag gaagccatgg gtgccaatat gctcaacacc atgctggaag ccttgaaacc
     2341 agtcttagaa gaactcagtc agggacagag tctcatggga atcctgtcca actacgcgac
     2401 cgattctctg gtgactgcaa gctgtcgcat ggcctttcgc tacttgagcc gccaaaagga
     2461 tcaaggacga gagattgcgg agaaaattgc attggctagt cagtttgcgc aggctgatcc
     2521 ttaccgagct gctactcata ataaaggaat ttttaatggt attgatgcga ttttgattgc
     2581 cactggtaat gactggcgtg ccatcgaagc tggggcccat gcctttgcca gtcgagatgg
     2641 acgctatcaa ggtcttagct gctggacgct ggaccttgaa agagaagaat tggtcggtga
     2701 gatgaccctg cccatgcctg tagcgactaa gggtggctct atcggcctca acccacgtgt
     2761 agctctcagt catgatctac taggaaatcc ttctgccaga gaattagccc agattatcgt
     2821 gtccatcggt cttgctcaaa attttgcagc cctcaaagcc ttggtaagta cgggcatcca
     2881 gcaaggtcac atgaaactac aggccaaatc cctagctctc ctagctgggg ctagtgaatc
     2941 tgaagttgct cccctagtag agcgcctcat ctcagataaa acctttaacc tagagacagc
     3001 ccagcgctat ctcgaaaatt taagatcata aaaactcaga cgaatcggtc tgagttttct
     3061 tgtgtttaaa tactttttcc tggtaatagc gtaactggta agaagtaacc agttgtggcg
     3121 acttccttgc cttcaatctt ttgcaagaga agatcaatag tgagacaagc aatctcttcc
     3181 aaaggttgct tgatagtagc caattgaggg tagtaatttt cgataaagta ggtcccatca
     3241 tagccgatga ccttgagctc ttttgggaca gaaatgccca attcttgagc gattttaatg
     3301 accagaatag ctgtcaaatc atccgaagca aaaatggcat ctggtttttc ccgggtcaag
     3361 atattcttga tttccatttc ttttctgacg ggagaaaagt cactggaaac attgataata
     3421 ggagcttttg ggagtacgga tgcaaaacca gcgtggcgca gtccggttgg cgaattggaa
     3481 ttgtcattcc ctgtaatcat gatgatagac tgggcacctg tcttgaccaa ggtttgggca
     3541 gcaagaaccc caccagcata gttgtcagag gagacaacag ggatgtctgg cgataggttt
     3601 cggtcaaagg aaataatcgg cgctgtcaca cgattgtagt cttcgattcc taggttgtga
     3661 ctaccagaaa tgatgccgtc tacctgattg gcttccaaca tttcgatgta ttcgcgttcc
     3721 ttctcagaat catgttcact gttgcagatg atggtcttgt aaccattttt gaagagttgg
     3781 tgttccaatt tatcaatcaa ttctgcatag aaaacattgg aaatattggg gaaaatcaag
     3841 ccgattaact tagctgattt tccttgcaga ctacgagcca ggttgttggg tttatagccc
     3901 aattctctca tggcttcatt gactttttgg atggttttca cagatagata ccctttttta
     3961 ttgataaccc gagaaacggt agtaggactg acgcctgcaa gtttggcgac atcagttagt
     4021 tttgcgacca taatctaatt catagtaagt tccagttggg tttccagatt tgatcaggat
     4081 accattttgg tccgcatgtg ggaagacacg accagaaaat actttttctc ctttattgat
     4141 gaaaatttca aagacagagt tatcgatgaa gattgtagca gtagtagcct gattctcgat
     4201 agggcaagaa cgagttgtcc caaattcttg ggcatactgt tctccagcat ggctacgatc
     4261 cactgtcact tgaccgttta caaggtcaaa gttgattgaa agtcccttac cttctttatc
     4321 agcaagtaag acaatctcgc tctggctatt agcttccaag ttgagttcaa gttcgtaagt
     4381 gttcttggtt tgggaacggt ttgagaaggc ttcttcagaa gcacgaaggt ccttaatagc
     4441 agcgactgga tactggtaga gcttgtcgtc tttgatagtg agttccttga tcaaagagaa
     4501 ggttccttgg tgatcaaaac agtcagatgg gtaagaaaca tctggcaaac caagccagct
     4561 aactgctaga gcacgcccat caggagcgtt gaaggcttga gttgcatagg cttcgaaacc
     4621 gtaatccatg ttttgaagtt gagacacatc taccattttg gcatttttag ggtcaaagga
     4681 agccccaatc ttatacatat ttggaaagat attatcgtag tctagaactt tcttatccaa
     4741 tccttgtgga cagtagagaa ggacaggctg ttcctctaca aagaccagat taggacattc
     4801 catcatgtag gcagtacggt cgttagcaaa gtcaaggtcg ccaactgctt gccagtttgt
     4861 gtagtcgtta ttgacagcct tgtagagacg gacgaagcct tttttctcca agtcctgtcc
     4921 accgacgaca gcatagtatt gacctttaaa gttaaaaatt tgtggatcgc ggaagtggtc
     4981 agtagagtct gctggctggt caatcaagat cttgtcaatc tttgtaatct taccctcctt
     5041 gtccatcaaa gcaccgatct ggtatgggtg acggatccag ttttcatcgc gaacatttcc
     5101 tgtataaaat aggaataagt tatcgccaaa ttgcatggca gaaccagagt aggcaccgtg
     5161 gctatctaat ggagtatctg gtaaaacttt gattccagtt tctttaaagt gaaccaaatc
     5221 atcactttct agctgtgccc aagattttaa accgtgggct gcaccaaaag gaaaattctg
     5281 gtaaaagagg atccacttgc catcaaagta agaaaagcca tttgggtcgt tgagaagtcc
     5341 tgtttttggc tcaacatggt aatgagtatg ccatggagat tgtgccatat tttcctttat
     5401 atgttgaatt tcttcttgcg tccaatcttg ataaagtctg taacgacgct cagttgtcca
     5461 ttccattcat tcctccaaaa atcttatcac ttttaatagt aactgttttc gataaaaaat
     5521 gcaagccttt tatattaaaa aagagaaaaa actgtcaaac gattatcata aaataaatac
     5581 aggaaatcaa tcaaattttt acgaaaatgt gaaagataat gaaataaaag actttttaac
     5641 caaggtttca aacttatttt tcaagaaatt cctgatgaaa cagtcaaaaa caatcaatct
     5701 aaagcttgcc cactaagtag atagaatatt ttttctgcaa aacgcttgac atatttttga
     5761 aacatgataa aataatagtc gtaagggcga ataaaatcgc tttcaaacaa gaacaaaatg
     5821 ttatataagg agatttttgc aaatgaacaa tcaggaaatt gcaaaaaaag tcatcgatgc
     5881 cttgggcgga cgtgaaaatg tcaatagtgt tgcccactgt gcgactcgtc tacgtgtcat
     5941 ggtcaaagat gaagagaaaa tcaataaaga agtgattgag aacttggaaa aagttcaagg
     6001 tgctttcttt aactcagggc aataccaaat tatctttggt acaggtacag ttaacaaaat
     6061 gtacgatgaa gttgttgtac ttggcttacc aacatcatct aaggatgaca tgaaagcaga
     6121 agctgctaaa caagggaact ggttccaacg tgctatccgt actttcggtg atgttttcgt
     6181 tccaatcatc ccagttatcg tagcgacagg tctcttcatg ggtgtgcgtg gtcttttcaa
     6241 cgctcttgaa atgccacttc caggtgactt tgcaacttac acacaaatct tgacagatac
     6301 agccttcatc atcttgccag gtttggttgt gtggtcaacc ttccgtgtat ttggtggaaa
     6361 tcctgccgtt ggtatcgttc ttggtatgat gcttgtctct ggctcacttc caaacgcttg
     6421 ggcagttgct caaggtggtg aagtaacagc gatgaacttc tttggtttca tccctgttgt
     6481 tggtttgcaa ggttccgttc ttccagcctt catcatcggg gttgtcggag ctaaatttga
     6541 aaaagctgtc cgcaaggttg ttccagatgt cattgacctc ttggtaacac cattcgtgac
     6601 acttttggtc atgtctatcc ttggactctt tgtcattgga ccagttttcc acgttgttga
     6661 aaactacatc cttattgcta caaaagcgat tcttagcctg ccatttggtc ttggtggttt
     6721 cttgattggt ggggttcacc aattgatcgt cgtgtcaggt gtgcaccaca tcttcaactt
     6781 gcttgaagtg caattacttg ctgctgacca tgctaaccca ttcaacgcta tcatcacagc
     6841 tgctatgaca gctcaaggtg ctgctactgt tgcggttggt gttaaaacaa aaaatccaaa
     6901 actgaaaaca cttgctttcc cggctgctct ttctgccttc ctaggtatta cagagcctgc
     6961 tatcttcggg gtgaacttgc gcttccgtaa accattcttc ctttcattga ttgctggtgc
     7021 aatcggtggt ggattggctt ctatccttgg acttgctggt actggtaatg gtatcaccat
     7081 catccctggt acaatgcttt atgttggtaa cggacaactt ccacaatacc ttcttatggt
     7141 agctgtatca tttgcccttg gttttgctct tacttacatg tttggttacg aagatgaagt
     7201 agacgcaact gcagctgcaa aacaagctga agtggctgaa gaaaaagaag aagttgcgcc
     7261 agcagctctt caaaatgaaa cacttgtaac tcctatcgtc ggtgatgttg tcgctcttgc
     7321 tgatgtcaat gacccagtct tctcaagtgg agctatggga caaggtattg ctgtgaaacc
     7381 aagccaaggc gtggtctatg caccagctga tgctgaagtt tcaattgcct ttccaacagg
     7441 gcacgctttt ggtttgaaaa caagaaatgg tgctgaagtt ttgattcacg ttggtattga
     7501 cactgtatct atgaacggtg acggttttga agcaaaagtt gctcaaggta ataaggtgaa
     7561 agctggcgat gttcttggaa catttgactc aaacaaaatc gctgcagctg gacttgatga
     7621 tacaacaatg gttatcgtta caaatacagc tgactacgct tcagtagctc cagtcgcaac
     7681 aggttcagtt tcgaaggggg atgctgtgat cgaagtgaaa atctaatcaa tcctctctaa
     7741 tgtgaaaacg aacaaatgac atgtttgttc gtttttatta gatagtaaga tttacagagg
     7801 aaaatctaaa aaatagagac atttagactt tcgaagtatg ctataataaa gaaaataaaa
     7861 acaagaggtt tatcatgaca aaattatatg gaagcttgga agcgggcggt acaaagtttg
     7921 tctgtgctgt cggtgatgaa aactttaacg ttgtagaaaa aacacaattt ccaacaacaa
     7981 ctccaatcga aacaatcgat aaaaccattg agttcttctc aaaattcgat aaccttgctg
     8041 gtcttgcagt tggttcattt gggccgattg atattgacaa aaactcaaaa acttatggct
     8101 ttatcacgac gactccaaaa ccaaactggg caaatgtgga cttgcttggt gcccttcgtc
     8161 gcgccctaaa cgtgccaatg tacttcacaa cagacgtaaa cagctctgct tacggtgaag
     8221 tggttgcccg taacaatgct ggtggtcgta tcgaaaactt ggtttactac acaatcggta
     8281 caggtatcgg tgcaggtgtc atccaacgtg gtgagtttat cggtggtgtg ggtcaccctg
     8341 aaatgggtca ttattatgtt gctagacacc caatggatat tgaaaaagag tttaagggtg
     8401 tttgtccttt ccataaggga tgtctggaag gctatgcagc tggtccaagt ttggaagctc
     8461 gtacaggtgt acgtggggaa aatattgaac tcaacaaccc tgtttgggat gttcaagcct
     8521 actatatcgc tcaagctgcg gttaatgcga cagtgacttt ccgcccagac gtgattgtct
     8581 ttggtggagg ggtcatggct caacaacata tgctggaccg tgtccgtgag aaatttacat
     8641 ctcttcttaa tggttaccta ccagtaccag atgtgcgtga ctatatcgtg acgccagcag
     8701 tcgcaggaaa tggttctgcc acacttggga actttgttct tgcaaaagaa gtttcaaaat
     8761 aaagcacaaa atccgcttgg gaaaccaaac ggattttgtg gttgaaaaca atatttttga
     8821 gcctttcctt aagtgattac ggacggtagc gactttcttc gaaattccat acctaaactt
     8881 tgagacacta ggctcaaagt ttccgaatac ctgaaaccat tagatttcag gtgtttctat
     8941 cacggcggga aggctaggta agtcctcgcc tcactatcga aaaatatgca tgatttccat
     9001 accaaagtat atttagtatc aagctatagt taatctacgc tttaaaaatc cacttgggaa
     9061 accaaacgga ttttttacgt gtcaaagcat ttgccagaaa aagtcaataa tataggtcag
     9121 accgtaggta taaaccacga gggtaaaggg tttggtcaga atgatgatag tcatgtagcg
     9181 cttgaaactc atcttggtca gggcagccag catacagaga aagtcagctg ggctaatggg
     9241 ccaaatcatc ataaaaataa agaagcggtc aaaacgattg cccttatcta gccagccgat
     9301 atacttgtcg taggtgcgct tgctgacgac agactggaca aaggcagctc cgtataggcg
     9361 cactagataa aagataatgg cacagccaat cacgatgccg atatagttgt agatagtccc
     9421 gatgatgtgc ccgtagataa agaccccagc caccgaggtc aaggcccctg gaatgatagg
     9481 gacgacagtc tgtaaaatct gtaaaaagat aaagagaggt ggaccccaga tgcctgcctg
     9541 ctggataaag gcagagaggg tttccttgga ttgtaaaatc ccagcctgat aagcccaaat
     9601 acagaaaatc aaactcccaa ccccaccgac aatcgatgag atattgataa ctcgctgcag
     9661 aaggggagaa acagctttca tttgtttatc ctgtgacatg taaactcctc atagatagta
     9721 tatttctact ataccatatt ttggaggaga aagggggaat gagtcttttt tgataaggaa
     9781 tagaaagtaa atagcccttc gagacttaga ataggtctgt caactaaagg ttatatgcat
     9841 tctaggtttc gaataatcgc aattccataa atttaaaagc attctaagtt tcgaatagct
     9901 tatctgagat aattttgagg cattcgcgct ttcgaatagt cattttccct aaagtttaga
     9961 tgtattctga agctagaaag actaaaatct aaaagtagta agagtctctc tctgatggac
    10021 gtaatttatg gctagtatga atcctttgaa ttgttagtta attttaatat taatcagttc
    10081 tgaaataatt actaaatata gttagatggt gaattaatta ttgctaaatt tcaagttcaa
    10141 gttagtcatc cagaagtctt ctctggggga cttgtagttc aagcattttt taggatagtt
    10201 gttaatccac ttttcgatga atgcgacttc ctttgtagtc gttttcttag ttccctgagg
    10261 taaccatcta tgaatgaact tgttgtgatt tttattagat cctatagtgg tgtgcataat
    10321 agatataata gattgaaact agaatagtac gcatctactt ctaaaacatt gttagaaatc
    10381 gatttgactg tcccgatcta tttgtcctgt ttttatttca ttttactata taatccttag
    10441 aaaacatatc ggacaagcgg ttgaattccg ttccgtccat tagtagataa aggattactc
    10501 cttcttgaaa tgacagatga acttgtttct tataaaaatg ttgtctgaaa ctattcgctt
    10561 ttttccagaa gttttagagg aagaaaactt tatgaggaaa aaggagttac tcaaataaca
    10621 attcaggatt aaaaatagac agttgaggag cggaaggtat aaattaagtt tgctactgta
    10681 taatggattt atcactaata ctcttcgaaa atctcttcaa accacgtcag ctccgccttg
    10741 ccgtagatat agttactgac ttcgtcagtt ctatccacaa cctcaaaact gtgttttgag
    10801 ctgactacgt cagttctatc tgcaacctca aagctgtact ttgagcagcc tacggctagc
    10861 ttcctagttt gctctttgct tttcattgag tataaaagtg ctccaggcca tattttacac
    10921 agcaatagtc ttctaaaaat ggacacaaaa cgttgtaaag gctatcaaaa aggagtataa
    10981 tgagtgcaag aaatttcgga ggtgaaagat gctagaagta agaagtctag agaaaagttt
    11041 tggatccaag caagttttgt ttggtattga ctttcaagcg cgaccaggtc gtattttggg
    11101 actagtcgga aaaaatggtg ctggaaaaac aacgattttc catagtattt taaaattcct
    11161 agaatatcag ggagaaatcg gtctggatgg tcaggatatt cgtcaggaga cctatgctcg
    11221 gattggttat ctgcctgaag aacgcagtct catgcctaaa ttgacagttc ttgaacaagt
    11281 tcgctacttg gcgactctaa aaggcatgga tgccaaagaa gtcaaagaaa aactccctca
    11341 atggatgaag aggttggaag tgaaaggaaa gctgacagat aaaatcaaga gtctgtcaaa
    11401 aggaaatcag cagaagattc agctcattat tactctgatt catgaaccag acctgattat
    11461 cttggatgag ccttttagtg gattggaccc agttaataca gaattgctca aacaagtcat
    11521 ttttcaggaa aaagagcgcg gagcaaccat tatcttttct gaccatgtca tgaccaatgt
    11581 tgaggaactt tgtgacgata ttctgatgat ccgagatggc cgtgtggtct tgcacggacc
    11641 agttcaggat gtccgcaatc aatacgggaa aacgcgtctc tttgtttcaa gtgaacgaag
    11701 caaggaagaa ttggaaaatc ttcctcatgt caaacaggtg agcttgacca aacaaggcag
    11761 ttggaaattg attttggagg atgagagcgc tggaagggaa ctcttcccaa tcttgactca
    11821 aggtcaatat atcgcaacat ttgaccaaca agcgccaact atcgatgaaa tctttaaact
    11881 agaatcagga gtggaagtat gagaaatatg tgggttgtaa tcaaggaaac ctatcttcga
    11941 catgtcaagt catggagttt cttctttatg gtgatttcgc cgttcctctt tttaggaatc
    12001 tctgtaggaa ttgggcatat ccaaggttct tctatggcta aaaataataa agtggcagta
    12061 gtgacaacag tgccatctgt agcagaagga ctgaagaatg taaatggtgt taacttcgac
    12121 tataaagacg aagcaagtgc caaagaagca attaaagaag aaaaattaaa aggttatttg
    12181 accattgatc aagaagatag tgttctaaag gcagtttatc atggcgaaac atcgcttgaa
    12241 aatggaatta aatttgaggt tacaggtaca ctcaatgaac tgcaaaatca gcttaatcgt
    12301 tcaactgctt ccttgtctca agagcaggaa aaacgcttag cgcagacaat tcaattcaca
    12361 gaaaagattg atgaagccaa ggaaaataaa aagtttattc aaacaattgc agcaggtgcc
    12421 ttaggattct ttctttatat gattctgatt acctatgcgg gtgtaacagc tcaggaagtt
    12481 gccagtgaaa aaggcaccaa aattatggaa gtcgtttttt ctagcataag ggcaagtcac
    12541 tatttctatg cgcggatgat ggctctgttt ctagtgattt taacgcatat tgggatctat
    12601 gttgtaggtg gtctggctgc cgttttgctc tttaaagatt tgccattctt ggctcagtct
    12661 ggtattttgg ttcacttggg agatgctatc tcactgaata ccctgctctt tattttgatc
    12721 agtcttttca tgtacgtagt cttggcagcc ttcctaggat ctatggtttc tcgtcctgag
    12781 gactcaggga aagccttgtc gcctttgatg attttgatta tgggtagttt ttttggagtg
    12841 acagctctag gtgcagctgg tgacaatctc ctcttgaaga ttggttctta tattcccttt
    12901 atttcgacct tctttatgcc gtttcgaacg attaatggct atgcggaggg agcggaagca
    12961 tggatttcac ttgctattac agtgattttt gcggtggtag caacaggatt tatcggacgc
    13021 atgtatgcta gtctcgttct tcaaacggat gatttaggga tttggaaaac ctttaaacgt
    13081 gccttatctt ataaatagaa gagccttgcg aaagcgaggt ttttaaaggt gaaaagggtg
    13141 gaatcacgaa cctaattatg tacacattat gtaaacaggt tgcttgaaaa ctcaattgta
    13201 tagtgaactg aatctggaat aggataatat tacttctaaa acattcttat aaattgattt
    13261 gaattccaaa atcccatcgt tccgttctta tttcattttg cgatatagtg aaaggaaata
    13321 agtcagctca caaaaaacgc atattaccaa ggttcttatg aactgccccc caaaagttag
    13381 acagaaaaaa tctaactttt ggggggcagt acatattcaa cacctgatac tatgcgtttt
    13441 ctaattttaa agactttttg cctggtctct tttgttctat gagtatgtta catatctagg
    13501 taaaaattat ttaaagcaaa ttaaccttat ttctcaagat gtagtaggtt ccgagataaa
    13561 agatagctat gaatatgagt tcttcaacaa tgcctatgct tgctcccata tagaaattat
    13621 cattaaatcc tgcaagtgaa ttaatataga agttagtact ggtattgaag aagacttcaa
    13681 taaagccaac gacgatttgg ataccaatgt aggctgcaac agcgagtgct gtacggtatt
    13741 cattgaacag ttgtccaatg gaaatggcca agtagatgca gaggattcct gaaatagtat
    13801 ttagtaggaa ggatatacct gtaagaaaga tctgagggag atgtgtttct acaaatgtaa
    13861 tcacataaga aagaggaatc cattctggag ctgttaaagc cagaataata acagcactta
    13921 gagccaatac agcggtgcta atcaatgacc agataaaggc accgattagt ttggctgtga
    13981 tgatatggtg ttcagaaatt ggcaaggtca aagtcagata gccttgtcgg tcgtagacac
    14041 tacctttgaa gcgtttaata atcaagaaaa tggttgaaat cgcaagtgta agcatcaagc
    14101 caccaaagac tgtagctaga aaaagtagca tagtagcctg actttcttgg taaggtagat
    14161 ttttaaagcc ttgtgtctgt attccgatga gggcagaaag gactagcacg gctgcgtaga
    14221 gggctaaata ccacttgtta acatttttaa attcgtagtg aactaaattc caaaacataa
    14281 ataatctcct ttgcttaggc cttaaattcc tgacggaaga gttggtcaat ggattcacct
    14341 gactcgtagc gaatatcatc tacatttcct tgacggacga cttttccgtc ttttaggaag
    14401 acaatttcat ccaagattgg ctcgatatca gaaatcaagt gggtagaaat caaaacggta
    14461 gaagttggtg agtagttgtt gataatggta ttgaggatat aagcacgggc tgctggatcc
    14521 accccaccaa tgggttcatc caaaacatag agacgagcat cacggctcat aaccaaaatc
    14581 agttgaacct tttctttgtt tccttttgat agtttcttga gacgactatt ttcatcaatg
    14641 cccaggtctg caagtagatg atgggcgcgt tcaagattga aatctttata gaaggtcttg
    14701 aagtaggtta gggcttcttt gaccttcatt tgctcattga gataggtcgt atcaggcaaa
    14761 taagctacaa cggccttggt tgctgggctt gggtccatgt cgttgatgag gacacgtcct
    14821 tgatctggtt gtaagaggcc attaattagt ttaatcaggg ttgtttttcc tgagccgttt
    14881 ggcccaagaa ggccgacaat ttttccagct ggaatgtcaa gagaaacatt ttcaagggct
    14941 ggtgttgctc catatgattt ggatacattt tcaaatgcta gtaatgacat aggcttaaac
    15001 tcctttaata taatcactga ctacgcctgg tagttcttct ttttcatagc caaaatgggt
    15061 catggaggaa acgaagtgtt ccaattcttc ttctgataat tgtttgcgtg actgggcgat
    15121 tagctcctta tccttagtca caaatcgtcc agttgttcgc ttgctgtaga caaatccttc
    15181 tcgttcaagg tctgataagg ctctttggat ggtattggga ttgacaccag cctcgctagc
    15241 tagctccctc acggttggaa gttgttgatt gggttccagt gtatgggaaa caatctgaag
    15301 cttgattttc tccataatct gtaaatagat gggttttttg ttgtcaaatg tccaggacat
    15361 cttagtctcc tttcttttac cttgttgtct taattaaata atacaacaaa acaaaaaact
    15421 tgtcaagcaa aaagaagaat tgttttggga atcgcttaaa aaatggtata atgaaaagaa
    15481 aacgataagg agggaaagga tgcgttgtcc aaaatgtggg gctaccaagt caagtgttat
    15541 cgatagtcgc caagcagaag aagggaacac cattcgtaga agacgtgagt gcgacgaatg
    15601 ccaacaccgt tttacaacct acgaacgagt agaagaaaga accttagtgg ttgttaaaaa
    15661 agatggcaca cgggaacaat tctccagaga taaaatcttt aatgggatta tccgctcagc
    15721 ccagaaacgt cctgtgtcaa gtgatgaaat caacatggta gtcaatcgta tcgaacagaa
    15781 actccgtggt cgaaatgaaa atgaaattca aagtgaggac attggttcac tcgtcatgga
    15841 ggagttggct gaattggacg agattaccta tgtacgtttt gctagtgtct atcgtagttt
    15901 taaggatgtc agtgagttag agagcttgct ccaacaaatc acccagtcct ctaaaaagaa
    15961 aaaggaaaga taaatgaagc caattgaccg tttttcttat ctaaagaata atcgggtgtc
    16021 gcaagatacc tcatctctgg tacagtgcta cctcccgatt atcggtcagg aggcactgag
    16081 cctttatctt tatacaatca gtttttggga taatggtaga aaggaatatc ttttttcaag
    16141 cattctcaac catctcaact ttgggatgga tagactgata aaatcattga aaatcttatc
    16201 tgcttttaat ctcttgaccc tctatcaaaa gggtgatgtt tatcagctag ccctccatgc
    16261 tcctctatct agtcaagact tcttggggca tcctgtttat cgcagactct tagagaaaaa
    16321 gattggcgat gtagctgtgg aggatttgaa agttgaaagt gctgatggtg aagaaatacc
    16381 tgtctcactc aatcaagtct ttccagaatt ggcagaacta ggcagtcaag aagaccttgg
    16441 tctcaagaag aaagtggcca atgattttga cttggaacat tttcgccagc tgatggctcg
    16501 agatggactt cgttttgcgg atgagcagtc cgatgtctta aacctctttg ctattgccga
    16561 ggagaagaaa tggacttggt ttgaaaccta tcaattggcc aagtcaacag ctgtttccca
    16621 ggttatttca accaaacgca tgcgtgaaaa aattgctcaa aaaccagttt cctctgactt
    16681 tagtcttaag gaagcgacca ttatcaaaga agctaaaagt aaaactgccc tgcagttctt
    16741 agcagaaatc aagcaaacac gcaagggaac cattacccaa acagaaagag aactcttgca
    16801 acagatggct ggcttgggct tactggacga agtcatcaat attattctct tattgacctt
    16861 taataaggtg gattcggcaa atatcaatga gaaatatgcc atgaaggtag ccaatgacta
    16921 tgcctatcaa aagattcatt cggcagaaga ggccgtttta cgaattcgtg atcgagggca
    16981 gaaagcaaaa acacaaaaac agaatcagac tgccccagaa aaaaccaatg ttcctaaatg
    17041 gagtaatcct gaatataaga atgaaaccag cgaggaaact cgtctggaac tagaacgtaa
    17101 gaagcaagaa ctattagctc gattagaaaa aggaggagat tagatggaaa gtgtcggaga
    17161 cgtactcaaa cgtcaaccca gccgttttta ttatcaagat ttggtccaga aaatcatgaa
    17221 ggaccctgat gttgcggcct ttatccagca agaatcctta actccaaagg aattaaatcg
    17281 cagtatctcc aagtttaatc agtacatcac cgagcgtgac aagtttctcc gtggggatac
    17341 ggattatatt gccaaaggct acaagccgat tttggttaag aatcatggtt atgcagatgt
    17401 ttcatatgaa gaaactcctg agctaatcgc ggctgaaaaa gaagcggcta ttaagaaccg
    17461 tctcaagtta atcaatctac cagccagtct caagaaagct agtttggctc aagttgactt
    17521 ggatgatttg gggcgcttac cagtttttga aaagctacta gccttcgtgg agcaatatcc
    17581 agctattcga aaaggtcttt acttatatgg agactttggt gtgggtaaaa gtttcatggt
    17641 ggcggcctta gctcatgatt tatcagaaaa acgtggtgtt tcatcaactc tcctccacta
    17701 tcctagcttt gtcattgatg tcaaaaatgc tatcagtgat ggcaatgtta agaccttggt
    17761 ggatgagatt aagctgtctg aggtcctgat tttagatgat attggcgccg agcaatcaac
    17821 cgtttgggtg cgtgacgaaa tcctgcaggt cattctccaa tatcggatgc aggaaaattt
    17881 accgaccttt ttcacatcca acttcaactt tgaagatttg gagaagcatt ttgcgaaagt
    17941 gaaacatgga aatgacgaaa cctgggaagc cagacgggtc atggaacgca tccgttattt
    18001 ggctgaggag actcgtttag aaggagtaaa ccgtcgatga cagaaaccat taaattgatg
    18061 aaggctcata cttcagtgcg caggtttaaa gagcaagaaa ttccccaagt agacttaaat
    18121 gagattttga cagcagccca gatggcatca tcttggaaga atttccaatc ctactctgtg
    18181 attgtggtac gaagtcaaga gaagaaagat gccttgtatg aattggtacc tcaagaagcc
    18241 attcgccagt ctgctgtttt ccttctcttt gtcggagatt tgaaccgagc agaaaaggga
    18301 gcccgacttc ataccgacac cttccaaccc caaggtgtgg aaggtctctt gattagttcg
    18361 gtcgatgcag ctcttgctgg acaaaacgcc ttgttggcag ctgaaagctt gggctatggt
    18421 ggtgtgatta tcggtttggt tcgatacaag tctgaagaag tggcagagct ctttaaccta
    18481 cctgactaca cctattctgt ctttgggatg gcactgggtg tgccaaatca acatcatgat
    18541 atgaaaccga gactgccact agagaatgtt gtctttgagg aagaatacca agaacagtca
    18601 actgaggcaa tccaagctta tgaccgtgtt caggctgact atgctggggc gcgtgcgacc
    18661 acaagctgga gtcagcgcct agcagaacag tttggtcaag ctgaaccaag ctcaactaga
    18721 aaaaatcttg aacagaagaa attattgtag aaagtgagaa attatggccc taccaactat
    18781 tgccattgta ggacgtccca atgttgggaa atcaacccta tttaatcgga tcgctggtga
    18841 gcgaatctcc attgtagaag atgtcgaagg agtgacacgt gaccgtattt atgcaacggg
    18901 tgagtggctc aatcgttctt ttagcatgat tgatacagga ggaattgatg atgtcgatgc
    18961 tcctttcatg gaacaaatca agcaccaggc agaaattgcc atggaagaag cagatgttat
    19021 cgtttttgtc gtgtctggta aggaaggaat tactgatgca gacgaatacg tagctcgtaa
    19081 gctttataag acccacaaac cagttatcct cgcagtcaac aaggtggaca accctgagat
    19141 gagaaatgat atatatgatt tctatgctct cggtttgggt gaaccattgc ctatctcatc
    19201 tgtccatgga atcggtacag gggatgtgct agatgcgatc gtagaaaatc ttccaaatga
    19261 atatgaggaa gaaaatccag atgtcattaa gtttagcttg attggtcgtc ctaacgttgg
    19321 aaaatcaagc ttgatcaatg ctatcttggg agaagaccgt gttattgcta gtcctgttgc
    19381 tggaacaact cgtgatgcca ttgataccca ctttacagat acagatggtc aagagtttac
    19441 catgattgat acggctggta tgcgtaagtc tggtaaggtt tatgaaaata ctgagaaata
    19501 ctctgttatg cgtgccatgc gtgctattga ccgttcagat gtggtcttga tggtcatcaa
    19561 tgcggaagaa ggcattcgtg agtacgacaa gcgtatcgca ggatttgccc atgaagctgg
    19621 taaagggatg attatcgtgg tcaacaagtg ggatacgctt gaaaaagata accacactat
    19681 gaaaaactgg gaagaagata tccgtgagca gttccaatac ctgccttacg caccgattat
    19741 ctttgtatca gctttaacca agcaacgtct ccacaaactt cctgagatga ttaagcaaat
    19801 cagcgaaagt caaaatacac gtattccatc agctgtcttg aacgatgtca tcatggatgc
    19861 cattgccatc aacccaacac cgacagacaa aggaaaacgt ctcaagattt tctatgcgac
    19921 ccaagtggca accaaaccac caacctttgt catctttgtc aatgaagaag aactcatgca
    19981 cttttcttac ctgcgtttct tggaaaatca aatccgcaag gcctttgttt ttgagggaac
    20041 accgattcat ctcatcgcaa gaaaacgcaa ataaaaaagt agaatctgga atgacagttc
    20101 cggatttttt tgatataata aaataataga aaacgctatc aaaagaaaga gggtgatgtc
    20161 ggtgatggaa catttgttta aattcttact tttagcaccg tacttttatt ttgataactg
    20221 gattgagaag gccaacagaa atagtaagtt ttttccaatt ttttattatt tttactggtt
    20281 ttacatcccc ttctattctc tttttagcct tgcttggaca gttgtttcag ttctgttttt
    20341 caataccgtc ttgagaaatg tgacagatat caagttatgg ggcatttggt ttctttttat
    20401 tctgctagct attggtatga attggttaac ttattcctgt ttcaaagaaa tgtttcgctt
    20461 gagacaggaa ctagggaagt ctaagggtgg aaggcattga tttatatcgg tttctatttg
    20521 taggaggtgg ccttatggta cctctaaaat catttattac acgctattcc aaggtttata
    20581 ttggtaataa catttaatag aacgaaacta aagaaaacaa tttaaaagag gaggtttgtg
    20641 atggaacact tgtttaaaat gataatctta ttaccctgtt tttacttttt cagctggatt
    20701 gacaaggata atagagaaag taaatttttc ccaatttttt actattttta ctggatttac
    20761 atcaccctct atgctctttt tagccttgct tggacagttt tttcagttct gtttttcaat
    20821 atcgtcttga gaaatttgac agatatcaag ttatggggta tttggctatt attactactt
    20881 atcgcttttg ctagtgattg gttagcctat gtctttttca aaaaaatgct tgacttgaga
    20941 cgggaactag ggaagtctaa aggtgtgcat aaaggaaggt gtaggaacta aaaaatgact
    21001 gtatctatga tttgtttatg gagctataga tacagtcatt tttattttga ttatgaaact
    21061 tgagagaaat attcatcttg tatagtggat tgaatatgga ataatacaat acaacttata
    21121 aaacattggt ataaaatgct ttagatcccc taattgattc gttcatattc tattacaatc
    21181 tactataata aaatgatgag agttattaca aattataggt ttgaaaaatc attaatttct
    21241 ttttcgagta tttcaactaa tgcctcttct ttggttagtc gtaataaagt tattccttta
    21301 tcaatcaaat cggagttatg ttgtagtatt cccaagcgta cttgagagaa tccaagaata
    21361 tcgtatattt ttaattcttc tgctaatacc aaaagttgta gggtgattgt ttcacattct
    21421 ttgaataaat gatgttgaaa atatacagtg gagagattgg ctaaaaaaga tgataaaaat
    21481 acttttgttt ctcggaagta tttatatttc tcgatggttt tcataattct atcaataaga
    21541 aggggaagat tttcagaagg aaagaaaaag agaatggttc caagcaattt caaatcacta
    21601 atgtaccatg tatccatagg ttcaagatag tcccaaattt cttcagacaa atctttcaag
    21661 acgtggttgt ttttgaatcc tttagttcgt aactctgtga caatttttgt atgacgatag
    21721 atattttgaa taggaacatc gtgatgtgtc ttaagat
//
