LOCUS       NZ_CFVJ01000015        17937 bp    DNA     linear   CON 04-AUG-2024
DEFINITION  Streptococcus pneumoniae strain 17F/2, whole genome shotgun
            sequence.
ACCESSION   NZ_CFVJ01000015
VERSION     NZ_CFVJ01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001326475.1-RS_2024_08_04
            Annotation Date                   :: 08/04/2024 01:25:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,120
            CDSs (total)                      :: 2,087
            Genes (coding)                    :: 1,951
            CDSs (with protein)               :: 1,951
            Genes (RNA)                       :: 33
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 27
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 59 of 136
            Pseudo Genes (incomplete)         :: 74 of 136
            Pseudo Genes (internal stop)      :: 39 of 136
            Pseudo Genes (multiple problems)  :: 30 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:58:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4477
            Orig. end                         :: 22414
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CFVJ01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17937
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..17937
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17937
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:12937](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12937
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(139..1149)
                     /locus_tag="AP598_RS06660"
                     /old_locus_tag="ERS012477_01317"
     CDS             complement(139..1149)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /locus_tag="AP598_RS06660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01317"
                     /product="YeiH family protein"
                     /protein_id="WP_000009138.1"
                     /transl_table=11
                     /translation="MSFLSKNGAGILACLLISILSWYLGGFFPVIGAPVFAIFIGMLLH
                     PFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALIIA
                     YLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVIDAKEKEVAQAISVIFFFNVLAAL
                     IFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLTRTLA
                     IIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSFFTPLK
                     QLSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIGIF"
     gene            1298..2467
                     /locus_tag="AP598_RS06665"
                     /old_locus_tag="ERS012477_01318"
     CDS             1298..2467
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     8.4e-64. Score: 207.9. Matches aSDomain:
                     nrpspksdomains_AP598_RS06665_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /locus_tag="AP598_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01318"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_000366378.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.3e-64, bitscore:
                     208.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-09, bitscore:
                     27.0, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.8e-09,
                     bitscore: 27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPATFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     aSDomain        1391..2443
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AP598_RS06665_Aminotran_1_2.1"
                     /evalue="8.40E-64"
                     /label="AP598_RS06665_Aminotran_1_2.1"
                     /locus_tag="AP598_RS06665"
                     /protein_end="382"
                     /protein_start="31"
                     /score="207.9"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     TFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     gene            2464..3234
                     /gene="recO"
                     /locus_tag="AP598_RS06670"
                     /old_locus_tag="ERS012477_01319"
     CDS             2464..3234
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /locus_tag="AP598_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01319"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_000616164.1"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            3231..4223
                     /gene="plsX"
                     /locus_tag="AP598_RS06675"
                     /old_locus_tag="ERS012477_01320"
     CDS             3231..4223
                     /EC_number="2.3.1.274"
                     /GO_function="GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="plsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /locus_tag="AP598_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01320"
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="WP_000717458.1"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            4229..4462
                     /locus_tag="AP598_RS06680"
                     /old_locus_tag="ERS012477_01321"
     CDS             4229..4462
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 3e-11.
                     Score: 35.5. Matches aSDomain:
                     nrpspksdomains_AP598_RS06680_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /locus_tag="AP598_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01321"
                     /product="acyl carrier protein"
                     /protein_id="WP_000136447.1"
                     /sec_met_domain="PP-binding (E-value: 3.4e-12, bitscore:
                     38.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 1.2e-05, bitscore:
                     17.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     aSDomain        4253..4444
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AP598_RS06680_PP-binding.1"
                     /evalue="3.00E-11"
                     /label="AP598_RS06680_PP-binding.1"
                     /locus_tag="AP598_RS06680"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.5"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     gene            <4508..4798
                     /locus_tag="AP598_RS06685"
                     /old_locus_tag="ERS012477_01322"
                     /pseudo=""
     CDS             <4508..4798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="AP598_RS06685"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01322"
                     /product="transposase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RNIGQAGKILADSGYQGLMKIYPQAQTPRKSSKLKPLTVEDKACN
                     HALSKERSKVEXIFAKVKTFKMFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     misc_feature    complement(4516..4531)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(4840..4853)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     gene            5001..5231
                     /gene="blpU"
                     /locus_tag="AP598_RS06690"
                     /old_locus_tag="ERS012477_01323"
     CDS             5001..5231
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="AP598_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01323"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093487.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1e-17, bitscore:
                     55.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKTMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQL
                     GIKTRTWQGAATGAVGGAILGGVAYAATCWW"
     gene            5234..5359
                     /locus_tag="AP598_RS12485"
                     /old_locus_tag="ERS012477_01324"
     CDS             5234..5359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /locus_tag="AP598_RS12485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01324"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_000346297.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            5770..5964
                     /locus_tag="AP598_RS12490"
     CDS             5770..5964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757183.1"
                     /locus_tag="AP598_RS12490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000756776.1"
                     /transl_table=11
                     /translation="MKKVLKYFLVFVFLFLMNIFIFKILATLGFQLIMSEKSYIVLPLF
                     SLIVLYMIDKRIRKKKKSL"
     gene            5985..6878
                     /locus_tag="AP598_RS06705"
                     /old_locus_tag="ERS012477_01325"
     CDS             5985..6878
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343891.1"
                     /locus_tag="AP598_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01325"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_000343888.1"
                     /transl_table=11
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENGQ
                     ALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKEAI
                     LEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVND
                     LLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQTEDS
                     LIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQV
                     LVQRILAEKQIDFPTT"
     misc_feature    6930..6941
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            7421..7717
                     /locus_tag="AP598_RS06710"
                     /old_locus_tag="ERS012477_01326"
     CDS             7421..7717
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837727.1"
                     /locus_tag="AP598_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01326"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="WP_000837726.1"
                     /sec_met_domain="Bacteriocin_IId (E-value: 1.4e-22,
                     bitscore: 71.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTKA
                     AATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYILKKKGAAKAALW"
     gene            7724..8860
                     /locus_tag="AP598_RS06715"
                     /old_locus_tag="ERS012477_01327"
     CDS             7724..8860
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698829.1"
                     /locus_tag="AP598_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01327"
                     /product="hypothetical protein"
                     /protein_id="WP_000698828.1"
                     /transl_table=11
                     /translation="MKILSKKECESILGYLNFIGITLLFFVIISLSIYFKSYLPFQGKL
                     FLLFLVVDYATLNRYNMKLPIQSKKINTFYIRKNYIFLYLLAIVKKYYSFQILQSFIYL
                     FILYFLDIIGYFYLSITLCLIAIQIISLILPSLFSIISKLFLFLSIGLLSIEQGQVVIY
                     VILLNYFILVMGILDNHASNFYFKSSRMSQKRFRSSLFILLRFCWLNKGLTFSFILISI
                     LLSYLFWYMMTMLSIDDTKIPILFLYTSIYITLMEAIIGNHKSSIGVDLALLQLSALNH
                     SKMNFFFKNAQLMMLTHLISFLQFSLLLCLIPVTSYSNDIKSILLNLLLIPFNYFIAYV
                     YYKKALFLIKGTVSLLRWSFLVLYCFLIIFVILVGGIR"
     gene            8857..9339
                     /locus_tag="AP598_RS11230"
                     /old_locus_tag="ERS012477_01328"
     CDS             8857..9339
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232094.1"
                     /locus_tag="AP598_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01328"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_001232094.1"
                     /transl_table=11
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQFT
                     LTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHALIE
                     IPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL"
     gene            9336..9932
                     /locus_tag="AP598_RS06725"
                     /old_locus_tag="ERS012477_01329"
     CDS             9336..9932
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000687786.1"
                     /locus_tag="AP598_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01329"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_050090446.1"
                     /transl_table=11
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLLA
                     GLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINTFF
                     DNKIGDNYMTASTGTKFKLGLSLIFAKNWNYIFIDETLSTVDARSIDMIAKRLISMKES
                     STIIYVSHNLLNQELISKSQRILIEEGRVYEISNK"
     gene            9913..10404
                     /locus_tag="AP598_RS06730"
                     /old_locus_tag="ERS012477_01330"
     CDS             9913..10404
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671992.1"
                     /locus_tag="AP598_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01330"
                     /product="hypothetical protein"
                     /protein_id="WP_000671990.1"
                     /transl_table=11
                     /translation="MKFQTNNSLYKLMNLIIYLFLLYLFIDLLMKSGILDEQIDKLSEL
                     SNLFTIKIETILTVISVVFTFIATLIEYGFSLFLITLFFDKNKRNFGDILLSKNITLSF
                     SILLCYLFNPSDIKFAYFSVLTVLLIGITNYARFKNLRLTVVFSVPFLFNAIMSIINSF
                     "
     misc_feature    complement(10489..10502)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.43"
                     /tool="antismash"
     gene            10784..12937
                     /gene="comA"
                     /locus_tag="AP598_RS06735"
                     /old_locus_tag="ERS012477_01331"
     CDS             10784..12937
                     /codon_start=1
                     /gene="comA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /locus_tag="AP598_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01331"
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="WP_057485808.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.7e-43, bitscore:
                     137.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1120.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFHFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     gene            12950..14299
                     /gene="comB"
                     /locus_tag="AP598_RS06740"
                     /old_locus_tag="ERS012477_01332"
     CDS             12950..14299
                     /codon_start=1
                     /gene="comB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /locus_tag="AP598_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01332"
                     /product="competence pheromone export protein ComB"
                     /protein_id="WP_000801615.1"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGTSLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            14469..15176
                     /gene="purC"
                     /locus_tag="AP598_RS06745"
                     /old_locus_tag="ERS012477_01333"
     CDS             14469..15176
                     /EC_number="6.3.2.6"
                     /GO_function="GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /locus_tag="AP598_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_01333"
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="WP_000043301.1"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQGLK"
     misc_feature    complement(15247..15260)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.09"
                     /tool="antismash"
     misc_feature    15958..15972
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    16718..16728
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(17784..17799)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.72"
                     /tool="antismash"
ORIGIN
        1 gagcacacta gcaaactagg aaactagccg cgggctgctc aaaacaccgt tttgaggttg
       61 cagatagaac tgacgaagtc agtaacatat atacggcaag gcgacgttga cgtggtttga
      121 agagattttc gaagagtgtt agaaaatgcc gataagggtc tgcataccaa gagtggtgag
      181 gatgatggca atccagcaga tggctccaag aagaatggat tttccactgg atttgaccat
      241 agcgaccaga ttggttttga gaccgatagc actcatggcc atgacaataa ggaatttaga
      301 gagttgtttg agaggggtaa agaaactact ggacacacct agagaggtga gtagtgtagt
      361 gaggagagag gcaaggataa agtaaaggat aaaaagtggg aagacttttt tcagttgtag
      421 gctttgcttg ttttcttgtt ggcgactttg ccagtaggat agaaagagcg tgatagggat
      481 aatggccaaa gtacgtgtga gtttaacaat ggttgcagac tcgagggtat tgctttggta
      541 aagactgtcc caagcgctgg cggcagccgt tacagaggaa gtgtcgttga ccgcagtccc
      601 tgcaaagagg gcgaagcctt cattggatag atgaagccag gtgccgaggg ttggaaagat
      661 gagcgcagcc aagacattga agaaaaagat aacggaaatg gcttgggcta cttccttttc
      721 cttagcatca ataacgggcg ctgtcgctgc aatggcagaa cccccacaga tagaagaacc
      781 tactccaacc aaggtagcca gttttgtatc cagtgcaaag aaacgctgga agaggtaggc
      841 aataatcaga gctattgaga tagtggacag gatgacaggg agtgaagatt ggccaactgc
      901 gaagacctgc gagatattga gaccaaaacc aagcaagaca acggcatatt ggagcaactt
      961 cttggaacta aaggtcaaac cagcatccag ttgtttatag gacgagagaa agggatgtag
     1021 gagcatgcct atgaaaatgg caaaaacggg cgcgccaatc acagggaaga atcctcctaa
     1081 gtaccaagat aggatggaaa tgagaaggca ggccaagata cctgctccat tttttgatag
     1141 aaatgacata aaaacctcca aataaaatct attaccatta tagacctata aacaggaaaa
     1201 gtaaaataga aagtggaaag ctattctcta atgtattttt gcggtcgggg ggcttttgta
     1261 gtataataga gatacgtttt gaaagtagga ggtatctatg gacttaacta agcgctttaa
     1321 taaacagtta gataaaattc aagtttcgtt gattcgtcag tttgaccagg ttatttcgga
     1381 gattcctggg gtcttgcgtt tgaccttggg ggaacctgat tttacaacgc cagaccatgt
     1441 caaggaggcg gccaagcgag cgattgatca gaaccaatcc tactatacag ggatgagtgg
     1501 tctgctgact ctacgtcagg cagccagtga ctttgttaag gaaaagtacc aactggacta
     1561 tgctcctgaa aatgaaatct tggttacaat tggggcgaca gaggctttat ctgcgacttt
     1621 gacggctatt ttggaagagg gagacaaggt acttttgcca gctcctgctt atccaggcta
     1681 tgaaccgatt gttaacttag ttggggcaga aattgttgag attgatacga ctgaaaatgg
     1741 ttttgtcttg actcctgaga tgttggagaa ggccattttg gagcagggtg ataagctcaa
     1801 ggcggttatt ctcaactatc cagccaatcc gacaggaatt acctacagtc gagagcagtt
     1861 agaggccttg gcagctgttt tacgcaagta cgaaattttt gttgtctgtg atgaggttta
     1921 ctcagaattg acctacacag gcgaagccca tgtgtctcta ggaacgatgt tgagagacca
     1981 ggctattatt atcaatggtt tgtctaaatc gcatgccatg acaggttggc gtttggggct
     2041 gattttcgct cctgcgacct tcacagccca gttaatcaag agtcaccagt acttggtcac
     2101 tgccgcaaat accatggcgc aacatgctgc ggtagaagcc ttgacggctg gtaaaaacga
     2161 tgcggagccc atgaagaagg aatatatcca acgtcgggac tatatcatcg aaaaaatgac
     2221 tgctcttggt tttgagatta tcaaaccaga cggtgccttc tatatttttg ctaaaattcc
     2281 agcgggctac aatcaagact cctttgcttt tctgaaggat tttgctcaga agaaggccgt
     2341 tgcctttatc cctggtgcag cctttggacg ttacggggaa ggctacgtcc gcctatctta
     2401 tgcagccagc atggagacta tcaaagaagc catgaaacga cttgaggagt acatgagaga
     2461 agcatgattc agtctatcac gagtcaaggc ttggtgcttt acaatcgcaa ttttcgtgag
     2521 gatgacaagc tcgtcaaaat ttttacagag caggttggca aacgcatgtt ttttgtcaaa
     2581 cacgctggtc agtctaagct ggcgcctgtt attcagccct tggtgctggc acgatttctc
     2641 ttgcgaatca atgatgacgg actcagttac atcgaagact atcatgaggt catgactttt
     2701 cccaagatta atagtgacct ctttgtcatg gcctatgcga cctatgtggc agctcttgca
     2761 gatgctagtt tgcaggacaa tcagcaggat gctcccttgt ttgctttttt gcaaaagact
     2821 ttggagttga tggaagcagg cttggattat caggttttga ccaatatttt tgaaattcaa
     2881 attttgactc gatttggaat cagcctcaat tttaatgagt gtgtcttctg ccatcgggtt
     2941 ggtcaggctt ttgacttttc tttcaaatat ggagcctgcc tctgtccaga gcattatcat
     3001 gaggataaga gacgttgtca tctcaatccc aatatcccct atctgctcaa tcaatttcaa
     3061 gctattgatt ttgagacttt ggagaccatt tcgctcaagc ctggaatcaa gcaagagcta
     3121 cgccaattta tggatcaact atatgaagag tacgttggga ttcacctaaa atcaaagaaa
     3181 tttattgatt ccctagcaga ctggggacaa ttactaaaag aggaaaagaa atgaaaaaaa
     3241 tcgcagtaga tgccatgggg ggcgattacg cacctcaggc cattgttgag ggtgtcaatc
     3301 aagccctatc tgacttttca gatatcgagg ttcaacttta cggagatgaa gctaaaatca
     3361 agcaatatct gacagcgaca gagcgcgtca gcattatcca tacggatgag aagattgatt
     3421 cggatgatga acctacgaga gctattagga ataagaaaaa tgccagtatg gtattggcag
     3481 ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat acaggtgcct
     3541 tgttggcagc aggattcttc atcgtgggtc gtatcaagaa tatcgaccgt cctggactca
     3601 tgtctacctt gcctaccgtt gatggaaaag gttttgacat gctagacctt ggtgccaatg
     3661 cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc tatgctaaaa
     3721 atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca gagagtagca
     3781 agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa agtttgaact
     3841 ttatcggaaa cgtggaagcg cgtgatttga tgaatggcgt tgcagatgtt gttgtggcag
     3901 atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg ggaatcatgg
     3961 gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt gccctccttc
     4021 tcaaggacag cctcagtggt ttgaaaaaac agctcaatta ttcagatgtt ggtggagcgg
     4081 tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat gccaaggctg
     4141 tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt gcccagactg
     4201 cgcgtgaatt ttcaggagaa taaaagagat gacagaaaaa gaaatttttg accgtattgt
     4261 gaccattatc caagagcgac agggagagga ctttgtcgtg acagaatcct tgagtctgaa
     4321 agacgatttg gatgcggatt ctgttgactt gatggagttt atcttgactc tggaagatga
     4381 atttagtatc gaaatcagcg atgaagaaat tgaccaactc caaaacgtag gagatgtggt
     4441 taaaatcatt caaggaaaat agtaatcgga gttccaagtc aacggaagta gatggttttt
     4501 agaaatgaga aatatcggac aagctggtaa aatcttggct gacagtggtt atcaagggct
     4561 catgaagata tatcctcaag cacaaactcc acgtaaatcc agcaaactca agccgctaac
     4621 agttgaagat aaagcctgta atcatgcgct atctaaggag agaagcaagg ttgagaanat
     4681 ctttgccaaa gtaaaaacgt ttaaaatgtt ttcaacaacc tatcgaaatc atcgtaaacg
     4741 cttcggatta cgaatgaatt tgattgctgg tattatcaat catgaactag gattctagtt
     4801 ttgcaggaag tctaatagta aaaaagtgat tagaaaacat cttttttaaa aatagagatg
     4861 attttgaaac aaaaaagcta attcaagacg tttcgatgcc aattcaagat ttggatgaaa
     4921 aaaattaata gatactgtta tactaaactt gtcaagtttg taacaagaca aatattaaaa
     4981 ataaaaaaga ggtattcgtt atgaatacaa aaacgatgtc acaatttgaa attatggata
     5041 ctgagatgct tgcttgcgtt gaaggtggcg gatgcaattg gggagatttt gccaaagcag
     5101 gtgttggagg aggagcagca cgaggtcttc agctaggaat taaaacaaga acatggcaag
     5161 gtgcagcaac tggtgctgtg ggaggagcta tacttggagg tgtggcctat gcagcgacat
     5221 gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg
     5281 tccttatatg gatgatttaa ttagaaaaaa atttttaaag tcttcggaga agaaaacaga
     5341 aaaatctgtt aaaaaataat caaaactata aatgatgaat ctgaatcaaa attattttgc
     5401 gcatgtaaat aggagtctta tagtaacgag tcaaaaaagg agtaactatg aatcgtaatt
     5461 tagaacggtg ttatctattc tgactaggaa tagatcatac cagaggtggc ttagaaatag
     5521 cggggacatt agaaattgaa ggaactttaa ataggatgtc gtaaatgttg ctatcaatga
     5581 tttatttgtc ccaagcttgc ctagggtgtc agtaaaaaat cattttcctt tcatatcata
     5641 tttttagtag ataggatgtt tgttctgtct attttttgcc aaaaaaagtg cagtcgaagt
     5701 gtttatttgg agttttatat atattttcga taaaataggt gtagaaatta ggaaagttga
     5761 agaaaagaaa tgaagaaggt tttaaaatat tttttagtat ttgtttttct atttttgatg
     5821 aatattttca tctttaagat actagcaacc ctgggatttc agctgataat gagtgaaaag
     5881 agttatattg ttctaccgct gttttcgctt atcgttttat atatgattga caaaagaatt
     5941 aggaagaaaa agaaatcttt gtaatcaact taaggagtat tactatggat gagttgaaac
     6001 gtgaaattgg ttataaaatc aaaactatta ggcgatcttg tggaaaaact cagatagata
     6061 tttgtggtga tgaatcagag ttgacgattc gtcagctagc acgtattgaa aatgggcaag
     6121 ctttagcaac acttcctaaa ttattattga ttgcggataa acttggagta tcattacaga
     6181 atattgtgga tgttaaggtt atagagattc caaaaggatt cctaaaactc aaagatgagc
     6241 tgattcattc tcaaacctac gctgataagg gaagaatcga acgaaaagaa gctatacttg
     6301 aggaaatata tgaaaactat tatgagaatt tgcctgagga agagcagtta attgtggatg
     6361 tgacacaagc tcgttttgat atttatggta gttcagatgt gacctacggt ttagggttag
     6421 tggaagaata tttccagcag ttattaaaaa agaaatattt ttctgtaaat gatttgttga
     6481 ttattgaatt gtatttcttt tgttgtgcta tgggattaga agataaagaa cattttgagg
     6541 agttagctca aaaagtattg ctatgttcag aatatgaaga taaggctagc ctagttcaaa
     6601 tggaaaaagt tcttctgagc ctatttatcc aaattcagac agaagatagt ctgatatata
     6661 ttcaaacatt tgagaaaatt attgctaaaa caagacatgt tttttaccga cctcatctat
     6721 ttttgctaaa ggcaaaatat gctttatttg tagacaagaa tattttagag gcagaaagtt
     6781 tctatgaaaa ggcgatttct ctagcagaat tgctagacga tcaggtatta gttcagagaa
     6841 ttttagcaga aaaacagata gatttcccaa caacctgact tctaagtcag gttgtttttt
     6901 tcatgttttt gctatactaa acctataaag aaaacgttct caaaaagaaa ggaggtttat
     6961 tatggttgga acgttatttg tccttttaag tataggagtc tggttctatc tataatatcg
     7021 ggtagagatt aatggaacaa ggtattctta tattggatta aaggaatgtt ttaataggtt
     7081 tcctacatta gtatagagga tgaaactcaa ttttcaatga tatagaagag ttatttggag
     7141 attgtgaggg ttgagtatgt ttatttatga tgtaggaagt gtaaactaaa aaggaggtag
     7201 taatcgtata aaagttaaat agacattatc ttttattgag tcttagtgat ataaaagtaa
     7261 tttgataatc taggaaaatg tagtagtaat ttatttatta tagatatgtt aataaaagta
     7321 gtataaaata tagacgaaca tttgaagaga gttaggaata caacatgtgc gaattaactc
     7381 tcaataaaac atacataata tacaaaagga gtacactaaa atgaaatcta aaagaatgga
     7441 atttcataat aaatttctta ttgtttcagc aatgttagca gtcattagtt ggttaagctt
     7501 aggtgttgtt tcttttccta tgttggctgg gacattagga atttcgacaa aagctgctgc
     7561 tactgtagtc aatttgatta gtgcttatag tacagttaca gcagtaattt caattgtagg
     7621 tgcaatcaca ggagtaggtt ctattggttc gggtattgca gcaacagttc tttatatatt
     7681 gaaaaagaaa ggtgctgcta aagcagctct atggtagaac tagatgaaaa tactttctaa
     7741 aaaagaatgt gaaagtattt taggttatct taattttatt gggataaccc ttttgttttt
     7801 tgttatcata agtttgtcaa tctattttaa aagctatctt ccttttcaag ggaaattatt
     7861 tttacttttt ttggtagtag attacgctac tttgaatcgt tataatatga aactgcctat
     7921 ccaaagtaaa aaaataaata ctttctatat aaggaaaaac tatatttttc tctatcttct
     7981 tgccattgtc aagaaatatt attctttcca aattttacaa tcattcattt atttatttat
     8041 tttgtatttt ctagatatta ttggatattt ttatttatcc attactcttt gtttgatagc
     8101 tattcaaatt atttctttaa ttctacctag tttgttttca attataagta aattgttctt
     8161 atttttatct ataggactat tgtctataga acaaggacaa gttgtaattt atgtcatact
     8221 actcaattat tttattttag tcatggggat attagataat catgcgagta atttctattt
     8281 taaaagcagt cgaatgagtc aaaaaagatt tcgtagcagt ctatttatat tgcttcgttt
     8341 ttgttggtta aataaagggt taactttttc ttttattttg attagtattc ttctttccta
     8401 tctattttgg tatatgatga cgatgttatc aattgatgac acaaaaatac caatattatt
     8461 tctttatacc tcaatatata ttacattaat ggaggcaata atagggaatc ataaatcctc
     8521 aattggggta gatctagctt tacttcaatt atctgctctt aatcattcta aaatgaattt
     8581 cttttttaag aatgcacaac taatgatgtt gacgcattta atctctttct tacaattttc
     8641 attgttgtta tgtttgattc cggtgacaag ttatagtaat gatataaaaa gtattttgtt
     8701 gaatttgtta ttgattccat tcaattattt tatagcctat gtctattata agaaagctct
     8761 atttttaatt aaaggtacag ttagtttatt gagatggagt tttctggttt tatattgttt
     8821 tctgataata tttgtaattt tagtaggggg cattagatga gaaaaagtgg ttttctgatt
     8881 tactatgtgt tattttgtat agtctgtttt ttactaggtt tacttttaag ctttatatta
     8941 aaaaatgaga cttttgctac tatacctccg aaactggaat tacaatttac attgacagtt
     9001 ttacaggcaa attctacaaa ttttttgcta tatctattct gttttccgat ttcgccctta
     9061 ttgcaacttt ttgatttgct atctttagga atacaattgg gtatatctgg tcagatgatt
     9121 ggaatagtag ctacaataaa aggaatatta cctcatgctc ttattgaaat accgaatttt
     9181 atttggtatc aaggtatgag tcagtatctt ttataccgat tattgaagga taggggaatt
     9241 aaaaatatac ttatttatat aaaaagtaat ttaaaatggt atatcatttc ttatctttta
     9301 ttaattttag cagcgttgat agagggaatt aaattatgaa aattgaaaat gaatctaaaa
     9361 gttatgataa atgtatattg aaaaatatat cactagagat tgataaggga atttacagag
     9421 ttgaaggaga gaatggttca ggaaagagca cccttctaca acttttagct gggctagaga
     9481 cttttgatag tggtttaaag aattgtgtct ccaaagatgt actatacctt gataccaatc
     9541 agcttggggt tgttccattt actatagaag aaaatttgca gttgttgtgt gattcttttc
     9601 aaatccatct atcatttgag gataaagaac aaattaatac tttttttgat aataaaatcg
     9661 gagataacta tatgacagca tctactggaa caaaattcaa attaggctta tccttaattt
     9721 ttgctaaaaa ttggaattat atttttattg atgagacttt atcaacagtg gatgcaagaa
     9781 gtattgatat gattgctaaa cgcttaattt ccatgaaaga aagctctact attatatatg
     9841 tatctcataa tttattgaat caagaattga ttagcaaatc tcaaaggatt ttaatagagg
     9901 aaggacgggt ttatgaaatt tcaaacaaat aatagtttat acaaattaat gaatctgatt
     9961 atttatcttt ttcttttata tttgtttatt gatttactga tgaagtcggg aattttagat
    10021 gaacaaattg ataaattatc tgaactatct aatcttttta caattaaaat agaaacaata
    10081 ttgacagtga tttctgttgt tttcacattt atagcaactc ttattgaata tggattttct
    10141 ctctttctga ttacattatt ttttgataag aataagagga actttggaga tattctttta
    10201 tctaaaaata taaccttaag ttttagcatt ttactttgtt atttatttaa tccatcggat
    10261 ataaagtttg cctatttcag cgtattgaca gtattactaa ttgggataac aaattatgcg
    10321 agatttaaaa atttaagatt gacagtagtg ttttctgtac catttttatt taatgctata
    10381 atgtctatta taaatagttt ttagaaatac taaaattttt ttctttactt aataatgata
    10441 tgaaatcatt tcggttttgt taacttgtaa ttcttatatt ttctaggtag aacgtttgtt
    10501 ctgcctattt ttttatccaa aaagtgcagt tgggagggag ataggctcat ttgggaagga
    10561 agtccagttt ttgtttagtg attggggtaa gatagttgtt atcagatgag tttatactct
    10621 tcgaaaatca aattcaaacc acgtcagcgt cgccttgccg tatatatgtg actgactttg
    10681 tcagtcttat ctacaacctc aaaacagtgt tttgagcagc ctgcggctag cttcctagtt
    10741 tgctctttga ttttcattga gtattaggga aaaggagatg aatatgaaat ttgggaaacg
    10801 tcactatcgt ccgcaagtgg atcagatgga ctgcggtgta gcttcattag ccatggtttt
    10861 tggctactat ggtagttatt attttttggc tcacttgcga gaattggcta agacgaccat
    10921 ggatgggacg acggctttgg gcttggtcaa ggtggcagag gagattggtt ttgagacgcg
    10981 agccattaag gcggatatga cgctttttga cttgccggat ttgacttttc attttgttgc
    11041 ccatgtgctt aaggaaggga aattgctcca ctactatgtg gtgactgggc aggataagga
    11101 tagcattcat attgccgatc cagatcccgg ggtgaagttg actaaactgc cacgtgagcg
    11161 ttttgaggaa gaatggacag gagtgactct ttttatggca cctagtccag actataagcc
    11221 tcataaggaa caaaaaaatg gtctgctctc ttttatccct atattagtga agcagcgtgg
    11281 cttgattgcc aatatcgttt tggcaacact cttggtaacc gtgattaaca ttgtgggttc
    11341 ttattatctg cagtctatca ttgataccta tgtgccagat cagatgcgtt cgacactagg
    11401 gattatttct attgggctag tcatcgtcta catcctccag caaatcttgt cttacgctca
    11461 ggagtatctc ttgcttgttt tggggcaacg cttgtcgatt gacgtgattt tgtcctatat
    11521 caagcatgtt tttcacctcc ctatgtcctt ctttgcgaca cgcaggacag gggagatcgt
    11581 gtctcgtttt acagatgcta acagtatcat cgatgcgctg gcttcgacca tcctttcgat
    11641 tttcctagat gtgtcaacgg ttgtcattat ttcccttgtt ctattttcac aaaataccaa
    11701 tctctttttc atgactttat tggcgcttcc tatctacaca gtgattatct ttgcctttat
    11761 gaagccgttt gaaaagatga atcgggatac catggaagcc aatgcggttc tgtcttcttc
    11821 tatcattgag gacatcaacg gtattgagac tatcaagtcc ttgaccagtg aaagtcagcg
    11881 ttaccaaaaa attgacaagg aatttgtgga ttatctgaag aaatccttta cctatagtcg
    11941 agcagagagt cagcaaaagg ctctgaaaaa ggttgcccat ctcttgctta atgtcggcat
    12001 tctctggatg ggggctgttc tggtcatgga tggcaagatg agtttggggc agttgattac
    12061 ctataatacc ttgctggttt actttaccaa tcctttggaa aatatcatca atctgcaaac
    12121 caagcttcag acagcgcagg ttgccaataa ccgtctaaat gaagtgtatc tagtagcttc
    12181 tgagtttgag gagaagaaaa cagttgagga tttgagcttg atgaagggag atatgacctt
    12241 caagcaggtt cattacaagt atggctatgg tcgagacgtc ttgtcggata tcaatttaac
    12301 cgttccccaa gggtctaagg tggcttttgt ggggatttca gggtcaggta agacgacttt
    12361 ggccaagatg atggttaatt tttacgaccc aagtcaaggg gagattagtc tgggtggtgt
    12421 caatctcaat cagattgata aaaaagccct gcgccagtac atcaactatc tgcctcaaca
    12481 gccctatgtc tttaacggaa cgattttgga gaatcttctt ttgggagcca aggaggggac
    12541 gacacaggaa gatatcttac gggcggtcga attggcagag attcgagagg atatcgagcg
    12601 catgccactg aattatcaga cagaattgac ttcggatggg gcagggattt caggtggtca
    12661 acgtcagaga atcgctttgg cgcgtgctct cttgacagat gcgccggtct tgattttgga
    12721 tgaggcgact agcagtttgg atattttgac agagaagcgg attgtcgata atctcattgc
    12781 tttggacaag accttgattt tcattgctca ccgcttgact attgctgagc ggacagagaa
    12841 ggtggttgtc ttggatcagg gcaagattgt cgaagaagga aagcatgctg atttgcttgc
    12901 acagggaggc ttttacgccc atttggtcaa tagctagaaa gaggagagga tgaaaccaga
    12961 atttttagaa agtgcggagt tttataatcg tcgttaccat aatttttcca gtagtgtgat
    13021 tgtacccatg gcccttctgc tcgtgttttt acttggcttt gcaactgttg cagagaagga
    13081 gatgagtttg tccactagag ctactgtcga acccagtcgt atccttgcaa atatccagtc
    13141 aactagcaac aatcgtattc ttgtcaatca tttggaagaa aataagctgg ttaagaaggg
    13201 ggatcttttg gttcaatacc aagaaggggc agagggtgtc caagcggagt cctatgccag
    13261 tcagttggac atgctaaagg atcaaaaaaa gcaattggag tatctgcaaa agagcctgca
    13321 agaaggggag aaccactttc cagaggagga taagtttggc taccaagcca cctttcgcga
    13381 ctacatcagt caagcaggca gtcttagggc tagtacatcg caacaaaatg agaccatcgc
    13441 gtcccagaat gcagcagcta gccaaaccca agccgaaatc ggcaacctca tcagtcaaac
    13501 agaggctaaa attcgcgatt accagacagc taagtcagct attgaaacag gtacttcctt
    13561 ggccggtcag aatctagcct actctcttta ccagtcctac aagtctcagg gcgaggaaaa
    13621 tccccaaact aaggttcagg cagttgcaca ggttgaagca cagatttctc agttagaatc
    13681 tagtcttgct acttaccgtg tccagtatgc aggttcaggt acccagcaag cctatgcgtc
    13741 agggttaagc agtcaattgg aatcccttaa atcccaacac ttggcaaagg ttggtcagga
    13801 attgaccctt ctagcccaga aaatcttgga ggcagagtca ggtaagaagg tacagggaaa
    13861 tcttttagac aaggggaaaa ttacggcaag tgaggatggg gtgcttcatc ttaatcctga
    13921 gaccagtgat tctagcatgg ttgcagaagg tgccctacta gcccaacttt atccatcttt
    13981 ggaaagagaa gggaaagcca aactcacagc ctatctaagt tcaaaagatg tagcaagaat
    14041 caaggtcggt gattctgttc gctatactac gactcatgat gccgggaatc aactttttct
    14101 agattctact attacaagta ttgatgcgac agctactaag actgagaaag ggaatttctt
    14161 taaaatcgag gcggagacta atctaacttc ggagcaggct gaaaaactta ggtacggggt
    14221 ggaaggccgt ctacagatga ttacgggcaa gaaaagttat ctacgttatt atttggatca
    14281 atttttgaac aaagagtaat gttcgtgttt ttagagttaa ataattttta aactgtgaga
    14341 aagattcttc ttgcagtttt ttctttacaa tttttgaaaa acatctgcta tttattcggt
    14401 taaattcttg tgttttttgg ttttttgtgg taaaatgtgc tcaagtaata cgaaaggcga
    14461 actttaaaat gtcaaaacaa ttgatctatt cgggaaaagc taaagatatc tatacaactg
    14521 aggatgaaaa tcttattatt tcaacttaca aggaccaggc gactgctttc aatggtgtca
    14581 agaaggagca gattgcaggt aagggagtct tgaataatca gatttcatct tttatttttg
    14641 agaaattaaa tgcggctggt gtggcgactc actttgtgga gaaactttca gacacggaac
    14701 aactcaataa aaaggttaag attattcctt tggaagtcgt gctccgcaac tatactgctg
    14761 gttccttttc aaaacgtttt ggtgtggatg agggaatcgc cttggagact ccgattgtcg
    14821 aattttacta caaaaatgat gatttggatg atccatttat caatgatgag catgtgaaat
    14881 tcctacagat tgcggatgac cagcagattg cctacttgaa ggaagaaacg cgtcgtatca
    14941 atgaactatt gaaagtctgg tttgctgaga ttgggcttaa attgattgac tttaagctag
    15001 agttcggttt tgacaaggat ggcaagatta tcttggcaga cgaattttca ccagataact
    15061 gccgcttgtg ggatgctgat ggcaaccaca tggataagga tgttttccgt agaggattgg
    15121 gagaactaac cgacgtttat gagattgttt gggaaaagtt gcagggttta aaataacaac
    15181 ctcaaggctg tttgggaata ttgcaagagc tgaaataaag gaataagaat tgatggataa
    15241 acgtattttt gttgaaaaaa aggctgattt tcaggtcaag tcagagagtt tggttagaga
    15301 gctccagcac aacttgggac tgtcaagctt gaaaagtatt cgtattgtgc aagtatatga
    15361 tgtatttgac ttggttgagg acttgtttgc acctgcagag aagcacattt tctctgagca
    15421 ggtaaccgac catgttttag atgaagtatc tgtgcaggcg gatcttgcta actatgcttt
    15481 ctttgccatt gaaagtctac cagggcagtt tgaccagcgt gcagcttcgt cacaggaagc
    15541 cttgcttttg ttgggaagtt cgagtgacgt gacagtcaac acagcccaac tttacttggt
    15601 gaataaagat attgatgcga ctgagttgga agctgtcaaa aactacctgc tcaatccagt
    15661 tgattctcgt ttcaaggata tcacgatagg gattgccaag caggagtttt cagagtcaga
    15721 caagaccatt ccaaaattgc ctttctttga aagctataca gcagaagact ttgctcgcta
    15781 caaggccgaa caagggatgg ccatggaagt ggatgatttg ctctttatcc aagactactt
    15841 taagtcaatc gggcgcgtgc caactgagac tgaactcaag gttttggaca cttactggtc
    15901 tgaccactgc cgtcatacga cttttgagac agagttgaaa cacatcgact tttcagcttc
    15961 taaatttcaa aagcaattgc agtcaaccta tgacaagtat attgccatgc gcgaggaatt
    16021 aggtcggtct gaaaaaccac aaaccttgat ggatatggcg actattttcg gtcgttatga
    16081 gcgtgctaat ggacgattgg atgatatgga agtctctgac gaaatcaatg cctgctcagt
    16141 tgaaattgaa gtggacgttg atggtgtcaa ggaaccttgg ctcctcatgt ttaaaaacga
    16201 aacccacaac catccaacag aaattgagcc atttggtgga gcggctacct gtattggtgg
    16261 agctattcgt gatccgttgt caggccgttc ctatgtttac caagccatgc gtatttcagg
    16321 tgctggtgat attacagcac cgatttcgga aactcgcgct gggaaattgc cacaacaagt
    16381 catttctaaa acagcaactc atggttattc ttcatatggt aaccagattg ggcttgccac
    16441 aacctacgtt cgtgaatact tccacccagg ctttgtagct aaacgtatgg aacttggtgc
    16501 cgttgttggt gcggctccca agggcaatgt tgtccgtgaa aaacctgaag caggtgatgt
    16561 gatcatcctt ctcggaggta aaacaggtcg tgatggtgtc ggtggtgcga cgggctcttc
    16621 taaggttcaa acagttgagt ctgtagagac tgctggtgct gaggttcaaa aaggaaatgc
    16681 catcgaagaa cgcaagattc agcgcctctt ccgtaatggc aatgtcactc gtctgatcaa
    16741 gaagtccaat gactttgggg caggcggtgt ctgtgtggct atcggtgaat tggcagacgg
    16801 tcttgaaatc gacctcaaca aggtgcctct taaataccag ggcttgaatg gtacagaaat
    16861 tgccatctct gaatcacaag aacggatggc ggtcgtggtt cgtcctgaag atgtggatac
    16921 cttcgttgcc gaatgtaaca aagaaaatat tgatgctgtt gtggtggcga cagtaactga
    16981 aaaaccaaat cttgtcatgc actggaatgg tgagacaatc gttgacttgg agcgtcgttt
    17041 ccttgacacc aatggtgtgc gcgtggttgt cgatgccaaa gttgtggaca aggatgtcaa
    17101 actcccagaa gagcgtcaaa catctgctga aacactggaa tcagataccc ttacggttct
    17161 atctgacctc aaccatgcaa gtcaaaaagg attacagact atctttgact gctctgttgg
    17221 acgctcaacg gttaatcacc cacttggtgg tcgttaccaa ctcacaccaa ctgaggcatc
    17281 tgtgcagaaa ttgccagttc aacacggtgt gactcatact gcgtcggtca ttgctcaagg
    17341 tttcaaccca tatgtagctg aatggtctcc ataccacggt gctgcttatg cggttatcga
    17401 agcaactgct cgtttggtgg ctgctggtgc caactggtct aaggctcgtt tctcttacca
    17461 agaatatttc gagcggatgg acaagcaagc agagcgtttc ggtcagccag tagctgctct
    17521 tctaggttct attgaagcac aaattcagct tggcttgcca tctatcggtg gtaaggactc
    17581 catgtctggt acctttgaag aattgaccgt tccgccaacc ttggttgcct ttggggtgac
    17641 gacggcagat agccgtaagg tgctctctcc agaatttaaa gctgttgggg aaaatatcta
    17701 ctacatccca ggtcaagccc tctctgcaga gattgatttt gacttgatta agaaaaattt
    17761 tgctcagttt gaagcaagcc aagctgacca taaagtgacg tctgcatcag ctgtcaaata
    17821 cggtggtgta gttgaaagtt tggctcttgc tacctttgga aactatattg gtgcagaggt
    17881 gaccttgcct gaacttaaaa cagctttgac agctcaatta ggcggctttg tcttcac
//
