LOCUS       NZ_CFVJ01000005        22991 bp    DNA     linear   CON 04-AUG-2024
DEFINITION  Streptococcus pneumoniae strain 17F/2, whole genome shotgun
            sequence.
ACCESSION   NZ_CFVJ01000005
VERSION     NZ_CFVJ01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Informatics,Pathogen.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAR-2015) SC, Wellcome Trust Sanger Institute, CB10
            1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001326475.1-RS_2024_08_04
            Annotation Date                   :: 08/04/2024 01:25:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,120
            CDSs (total)                      :: 2,087
            Genes (coding)                    :: 1,951
            CDSs (with protein)               :: 1,951
            Genes (RNA)                       :: 33
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 27
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 136
            CDSs (without protein)            :: 136
            Pseudo Genes (ambiguous residues) :: 0 of 136
            Pseudo Genes (frameshifted)       :: 59 of 136
            Pseudo Genes (incomplete)         :: 74 of 136
            Pseudo Genes (internal stop)      :: 39 of 136
            Pseudo Genes (multiple problems)  :: 30 of 136
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:58:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 64004
            Orig. end                         :: 86995
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CFVJ01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12991](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12991)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    190..202
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    243..258
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    1062..1073
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            1358..1771
                     /gene="ndk"
                     /locus_tag="AP598_RS03220"
                     /old_locus_tag="ERS012477_00627"
     CDS             1358..1771
                     /EC_number="2.7.4.6"
                     /GO_function="GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ndk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /locus_tag="AP598_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00627"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_000438289.1"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     misc_feature    1360..1373
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.04"
                     /tool="antismash"
     CDS             1895..2002
                     /gene="allorf_65899_66006"
                     /locus_tag="allorf_65899_66006"
                     /protein_id="allorf_65899_66006"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTISLSRSVRCETKKTPAMRVCVEGYTKKTPNAIQ"
     CDS_motif       1895..1951
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTISLSRSVRCETKKTPAM"
                     /locus_tag="allorf_65899_66006_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1952..2002
                     /prepeptide="core"
                     /locus_tag="allorf_65899_66006_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1771.0"
                     /monoisotopic_mass="1769.9"
                     /core_sequence="RVCVEGYTKKTPNAIQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTISLSRSVRCETKKTPAM"
                     /leader_location="[1894:1951](+)"
                     /alternative_weights="1789.1"
     gene            complement(2717..3349)
                     /locus_tag="AP598_RS03230"
                     /old_locus_tag="ERS012477_00629"
     CDS             complement(2717..3349)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="AP598_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00629"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_050315421.1"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQFIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            complement(3351..4118)
                     /locus_tag="AP598_RS03235"
                     /old_locus_tag="ERS012477_00630"
     CDS             complement(3351..4118)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="AP598_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00630"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_000078816.1"
                     /transl_table=11
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRISSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEIGVA
                     FLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            complement(4169..5908)
                     /locus_tag="AP598_RS03240"
                     /old_locus_tag="ERS012477_00631"
     CDS             complement(4169..5908)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="AP598_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00631"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000699969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.2e-38, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            complement(5932..8040)
                     /locus_tag="AP598_RS03245"
                     /old_locus_tag="ERS012477_00632"
     CDS             complement(5932..8040)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="AP598_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00632"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701298.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.9e-38, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            complement(8037..8966)
                     /locus_tag="AP598_RS03250"
                     /old_locus_tag="ERS012477_00633"
     CDS             complement(8037..8966)
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="AP598_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00633"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            complement(8947..9651)
                     /locus_tag="AP598_RS03255"
                     /old_locus_tag="ERS012477_00634"
     CDS             complement(8947..9651)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="AP598_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00634"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     misc_feature    complement(9788..9801)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.84"
                     /tool="antismash"
     gene            complement(10001..12991)
                     /locus_tag="AP598_RS03260"
                     /old_locus_tag="ERS012477_00635"
     CDS             complement(10001..12991)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="AP598_RS03260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00635"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_000875573.1"
                     /sec_met_domain="DUF4135 (E-value: 2e-91, bitscore: 299.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-52, bitscore:
                     170.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKNLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     gene            complement(13107..13295)
                     /gene="pneA2"
                     /locus_tag="AP598_RS03265"
                     /old_locus_tag="ERS012477_00636"
     CDS             complement(13107..13295)
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="AP598_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00636"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       complement(13221..13295)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="AP598_RS03265_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13107..13220)
                     /prepeptide="core"
                     /locus_tag="AP598_RS03265_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[13220:13295](-)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            complement(13302..13526)
                     /gene="pneA1"
                     /locus_tag="AP598_RS03270"
                     /old_locus_tag="ERS012477_00637"
     CDS             complement(13302..13526)
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="AP598_RS03270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00637"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       complement(13440..13526)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="AP598_RS03270_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13302..13439)
                     /prepeptide="core"
                     /locus_tag="AP598_RS03270_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[13439:13526](-)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            complement(13629..13799)
                     /locus_tag="AP598_RS12365"
                     /old_locus_tag="ERS012477_00638"
     CDS             complement(13629..13799)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="AP598_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00638"
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    13782..13797
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            13991..14854
                     /locus_tag="AP598_RS03280"
                     /old_locus_tag="ERS012477_00639"
     CDS             13991..14854
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="AP598_RS03280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00639"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093641.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEVKSNLSNFKHLSARLLDDRNYDDLEYLYKIEVERSTF
                     LTLEDRTYLEWIKSIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     misc_feature    14891..14908
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    14954..14967
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            15237..15857
                     /locus_tag="AP598_RS03285"
                     /old_locus_tag="ERS012477_00640"
     CDS             15237..15857
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="AP598_RS03285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00640"
                     /product="hypothetical protein"
                     /protein_id="WP_000839908.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            15943..16386
                     /gene="tsaE"
                     /locus_tag="AP598_RS03290"
                     /old_locus_tag="ERS012477_00641"
     CDS             15943..16386
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="AP598_RS03290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00641"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000288232.1"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            16376..16894
                     /locus_tag="AP598_RS03295"
                     /old_locus_tag="ERS012477_00642"
     CDS             16376..16894
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="AP598_RS03295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00642"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000455537.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            16902..17918
                     /locus_tag="AP598_RS03300"
                     /old_locus_tag="ERS012477_00643"
     CDS             16902..17918
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="AP598_RS03300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00643"
                     /product="LCP family protein"
                     /protein_id="WP_000239282.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     misc_feature    17963..17976
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    17964..17977
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     gene            18003..19259
                     /locus_tag="AP598_RS03305"
                     /old_locus_tag="ERS012477_00644"
     CDS             18003..19259
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="AP598_RS03305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00644"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_050100252.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGICLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     gene            19314..20480
                     /gene="recA"
                     /locus_tag="AP598_RS03310"
                     /old_locus_tag="ERS012477_00645"
     CDS             19314..20480
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="AP598_RS03310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00645"
                     /product="recombinase RecA"
                     /protein_id="WP_001085463.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVTLDLGDELEIEIEE"
     gene            20786..22156
                     /locus_tag="AP598_RS03315"
                     /old_locus_tag="ERS012477_00646"
     CDS             20786..22156
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="AP598_RS03315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ERS012477_00646"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001862691.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFAFPILLSNIFQQLYNTADVLIIGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGV
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQSSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAILATKVQS"
     misc_feature    22699..22713
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
ORIGIN
        1 ttatcatccg tgaggacgac tgtggaactg accgtggtct cttgatccgt tctatcgcag
       61 aaggaaaaga gatgatcgag tctctcgaag agcgtctcaa cggtcgttac actaagaaaa
      121 ctgttaaaca tccagaaact ggtgcagtga ttattggtcc aaatgaattg attacagaag
      181 acaaggcgcg tgaaattgtc aatgctggtg tggaagaagt gactatccgt tctgtattta
      241 catgtaacac tcgtcacggt gtctgccgtc actgttacgg tatcaacttg gcgactggtg
      301 atgcggttga agttggtgaa gcagttggta caatcgctgc ccaatctatc ggggaacctg
      361 gtacacagct tacaatgcgt accttccaca caggtggggt tgcctcaaat accgatatca
      421 ctcagggtct tcctcgtgtc caagaaatct ttgaagcccg caatcctaaa ggggaagcgg
      481 ttattacaga ggttaaagga caagttactg ctatcgaaga agatgcatca actcgtacca
      541 agaaagtctt tgttaagggt gaaactggcg aaggtgaata tgtcgttcca tttacagctc
      601 gtatgcgtgt cgaagttggg ggccaagtag cgcgtggtgc tgctctgaca gaaggttcta
      661 tccaaccaaa acgtctcctt gcagttcgtg atgtcttgtc agttgaaacg taccttctcg
      721 gtgaagtaca aaaagtttac cgtagccaag gggtagaaat cggtgacaaa cacatcgagg
      781 taatggttcg tcaaatgatc cgtaaagtcc gtgtcatgga tccaggtgat acagatcttc
      841 tcatgggtac cctcatggat atcaatgact ttacagatgc caacaaagat gtccttatcg
      901 caggtggagt tccagcgaca ggtcgcccag tccttatggg aattaccaaa gcctcacttg
      961 aaacaaacag tttcttgtca gcggcttcct tccaggaaac aactcgtgtc cttactgacg
     1021 cagctatccg tggtaagaaa gaccatctcc ttggacttaa agaaaatgtt atcatcggta
     1081 agatcatccc agctggtact ggtatggccc gttaccgtaa ccttgaacca catgctgtca
     1141 acgaagaaga ataccttaat cctccagtag aggaagaagg aaatgaagaa acaacagaag
     1201 tagttgtgga tactgccgtt gaaactgtgg aagaaacagt agaataagag agaatgagag
     1261 aacccgaggg ttctctcatt ctctcttctg aaaactttct ccatttttcc acgaaatgtg
     1321 gtaaaataaa agaaagaagc tgacaaagga gacgggtatg gaacaaacat tctttatcat
     1381 caaaccagat ggtgtaaaaa gagggctagt gggtgaagtg ttaaagcgca tcgaacaacg
     1441 tggatttaca atcgaaaaat tggagtttcg ttcacaggtt tcagaagagt tgattgacca
     1501 gcactatcag gacttggttg gtcagagttt ttacccaccg attcgtgaat tcatgacttc
     1561 aggtccagtt cttgtgggtg tcatttctgg tcccaaagta atcgaaactt ggcggaccat
     1621 gatgggtgca actcgtccag aagaagcttt accaggcact attcgaggtg attttgcaaa
     1681 agctgctgga gaaaatgaga ttatccaaaa tgttgtacat ggttcagatt cagaagagtc
     1741 agctaagcga gaaattgctc tttggtttta agagtggatt ggctcaatca attggttaaa
     1801 agctcatttg aatagaaagt atagtcaatt agtttaagac atgacgcatg atatcaaact
     1861 ttttagtttt tgatatggtg cgttttttga ttaagtgact attagtttgt ctcgctccgt
     1921 taggtgcgag acaaaaaaaa cacccgctat gcgggtgtgc gtcgaaggtt ataccaaaaa
     1981 aactccaaac gcgatacaat aaaggtgttc aatccaattg taaagcgaaa ggagaaaaat
     2041 atggcacaaa aggttctttt atcctgttct tgtttcaatt gactatattt ctatactttt
     2101 tcttcctttc tctgtgaaaa tcgcaagttt ttcccacctt ttctcaatac tgaaacaaca
     2161 tctttccaga acttcaataa tttctttttg tgttaaatca ttatttaact aaatctttgg
     2221 aggcaatacg ttttcaaagc tactttttta ccataggttt tgagccttca acacagatta
     2281 ctaagccaaa aatgctctaa atttttgaaa ttctaacaaa ttccactcaa ctttatcatc
     2341 atctttgact ttcacaatat cttcctcaaa ataacatgga ataaagatag ttttctttta
     2401 aaacggttgt aggaggaaaa tctctcctac actattattg attctgagag aaaattgcaa
     2461 aatatcatct accaaacttt caattattaa gattttttgc agtttatctg aattagaatc
     2521 gcaaggcttc tcaataatat aattgtcgaa ttttttcatt ctaacttcct ctccattatt
     2581 tcttccttta tcaagaaaaa gttacctcaa tattaataaa gtacaattct aaattaagta
     2641 caattctaaa ttaactccaa ttcttgattc atgataatat ttcagtaact catcgtgcaa
     2701 ttaaaaacaa ggatttttat ttcagatgat ccatcgtgaa cacttcatca gccatctccc
     2761 aaattgccgg attatgtgtt gcgataatga ttagcctatt atcatctcga agagatagca
     2821 aaatctccat aataaactga gaggttgctg ggtctattga agctgttggc tcatctgcca
     2881 gaataaaggg tggattcttt aagataattt ttgccaaggc aacccgttgc gattctccgc
     2941 ccgataactc aaagatgcgc ttatctaggt caagataaac caggccgacc tgttctaaag
     3001 cctgcttctg cctcaaccgc tgttccgacc gactcaactt ttgaccaatg agacctagct
     3061 taaggttttc ttcaatactt tggttttcaa ttaagccaaa gttctggaag aggtagccca
     3121 attcgtgacg gaaaaaatca cttgatttat aattggccaa gtctttacct cggtaaaaaa
     3181 tcgtcccatc ataaggttct aatttcccaa tcatgttcat caaggttgtt tttccgctac
     3241 cacttgaacc aattaaggca tagacttttc cagcctcaaa tgtcattgaa agattcgaaa
     3301 ataactctcg ttctccaaaa gatttactca cttgtttaag ttcaatcata ttaacctccc
     3361 ttcaaaacaa gcatggacat cttgttttct ttctgcattt ggacatgtaa ctgtaaaaga
     3421 gatagaccag taaagagtaa caagactaag aaagcaactc ctatctctac ctgaagaaat
     3481 acactcgcaa caaatcccag taaaaacaca cccagttgag caaagagata agtgcgatgg
     3541 atttctaaga acctgagacc tgcaatgcgt ttgataaaaa tggcacgtct aaattcttca
     3601 aagtagagcc tattcatagt gttaaacaac aagattgaag ttgcaatccc aagcacagct
     3661 cctgctagca ttacccaacg ttccctctgg atattatcca ataatgtgat gtagttgtgg
     3721 taacctgttt gcatttctga gacccaattt tcaatgcctt gtctctggat aagctcctgg
     3781 gcatcagaca attgattaaa gagaacgtag ttctgtactg cgtctatcca aaacaaaatg
     3841 gactgtggac cagttgattg gggtgttata acaatgatga ttggatcttt caaaaactgc
     3901 tggtaagaaa taggggtcgt attatacaca aaacgatcct gacctgattc taaataacct
     3961 accgtagcag tcatttgctg tcgttcatct tgactagata tgcgactggt taagtcgtct
     4021 tcaaaaacag atttataatg ttcttcctct gaacggaggt gttcaggcag caataagaca
     4081 aactccccta catcaaggtg attcatcttt tgactcattt tagttgaact gtaggactta
     4141 ctttttcaga gggctccaaa ttttattttc atttactttt tttagcccat aaaatattta
     4201 ccatacttat aaaaagtagt aatactccaa ctaaactgac ttgtaatgaa ttatatgtat
     4261 tttctgaagt gttaggtaaa taattttgag agtacccttc tcgggcaata gtaataatat
     4321 tgtgtgtgtt tatttgttta attccaatag tagtttgaat tctctcttcc aactcaatta
     4381 aattaacatt atctatgaaa ctatcccaac tttgttcatt tttatattct aattgtaaca
     4441 tattcaaatc atatctcaat acgtttggta tatttaacac ttttatacca ttttttactg
     4501 gtaatgtttc ttccagaatt ttttttacaa acatataatt atagggctga tcttttaatt
     4561 tgtatttatc aataatcatt gcaatcgcac cagaaacttt aggagcagca aatgagtttc
     4621 cataaagata cgtatatcct cctagtgttg ccgaaaaaat ccaatcttct ttatattttt
     4681 ctgcattaat aaagttatta agtcctaatt ctgaaagaga taatgttgag cctgcaggcg
     4741 catatattgc atcagaatcc cctttattgc taaaatctga taaattacct aagcgatcta
     4801 tgcctccgac cgaaattgta gatgagaaat aacttggaac atcaactact aatcctggtt
     4861 ttcttacttt tttgcgtgaa ctaataagtt tcaataaatc tgactgattt gatacattta
     4921 gggagtcatt ccctaatgca gctactataa ttactccttt ttgattcgcg taatcaatag
     4981 cctttttata cttcaaaaat gtttcaaaat catttgttcc gtcctcatat tctccatcaa
     5041 tcattaaata ttgtccagta ctaagattga taatatcatt gccatcatct acagcatcaa
     5101 aaattgcttt tacaatccaa tctggactag ctgacgactt accaaatatt ctatagacgt
     5161 taatattaac gtgaggattt actccattaa tattgtcatc ccctacaatt tgagctacaa
     5221 cagccgtacc atgacctaat ctatcttgaa tatctgatat tattccttcc tctccctcct
     5281 cttttcctaa atatccttta ttggggacat agttttttga gtgatttgaa agatttttca
     5341 gtaatccagt attttgtaaa tcgactcctg aatctaaaat agcaattgaa actttagaat
     5401 tacttttaga atataattta taactttcgc ctccaccagt aactttatct atatcccatt
     5461 catattttct tacaatcgac gattctaagt tatctttgtc atgctctata tttcctcctc
     5521 tattatctag atgagaaaca ttttccttaa ttttattatc taaattatct tcgcctagta
     5581 aattattact ttcagagtta acaatatcgt tatttatttg tggttcaagt tccaatttac
     5641 aacagttttt ttctaaatgt ttatctgttg ttacaaataa ttctgtctta tcgatttgaa
     5701 tacgaaattt attttggtct acttcttctt gatttttatt agaatagtca acctgttttt
     5761 catcagattc agaaaaactt tcgctagtct gagtgtgagt tatattgcca tcaagatttt
     5821 taggtatttc ttgagcagta acagaattat tgaacaaaca aaagaataat atcgctaaag
     5881 tccaatattt ttttttcata atcttcataa atttaccctt ttaatcaaaa actaattatt
     5941 tgaatacaat tgcttataaa tgcctcctag ttcaagaagt tctctatggg tcccaatctc
     6001 tacaatttca ccattatgca ttactaagat cttatctgca gacttgatag tatctagtcg
     6061 atgggcaatt aaaatcttag tggtaccgat ttcacttaag taagaagttg taatttgttg
     6121 agataaatta tctaaactac ttgttgcttc gtccaaaaca actaccgaag gtttcgacaa
     6181 aagacaacga gctaaaagta tcatttgctg ctgccctcca gaaaagttat taccttcttc
     6241 agcgatgatt gtctctaatc caagaggtaa agatttaact acattgctaa gaccaattga
     6301 atttagattt gtcattaatt cttcatctga aacaaagtgt ccaaatgtca aattctctct
     6361 taaggtacca taacttaggg ttgaattttg taacactgct ccaaaaatct ttctatacaa
     6421 tgtttgacca atttcttctt tttctactcc atcaacttct attgaaccaa tattaggttc
     6481 taataaacct aataaaattt tagctaatgt actcttacct gaacctgatt ctccaacaat
     6541 agcaacagtt tctccttttt taatagtaac atttattcct ttcaaaacat aatcatcaaa
     6601 taatccatat ttataccaaa tatcttttaa ttctattttt ttatcaaatt ttatatcttg
     6661 actgactctt tctggaatta attcggattt agtattaaac acatcctcta ttcttaaaaa
     6721 atatcccttt aataacatta attgtatata gttatcactt aaagaaatta taggagaaat
     6781 aaagtatggt gagactgtac ttattgctac aatttgtcct aacgtcaatt gttcgaatgt
     6841 ttttatattt acacctacaa taagggtcaa aacagggaga ataatttgta aaacattcgt
     6901 tatactacta acaattgata aatgtatatc aagttttcga cctatgatga gctgttttgt
     6961 attaaaatta tcccatttgt taatccaaaa ttcctcttct ccagttagct taatatcact
     7021 atttttagaa attacttcgg aagtaatatt ttgaacatta accttttctt ttatattttt
     7081 atcaattaaa ttttttgaga tttttatgat tggatacatt acaatagata gagctagact
     7141 tagtgatatt aaaaagatta ccatgtactt agaaaagcta aataaaacca cagcataaac
     7201 cacaatcatt aacaaatcaa gtatagctgc tataaaatta tttgatagta tttctcttat
     7261 ataaacaata gagttagctc taaaaagtat atcccctaaa gtacgttttt cataaaaact
     7321 gtaaggtaaa tatatcaaat gtttcataaa atcatagcta atctctttat ccattatata
     7381 ttttaaggat gcaacatata tctgtcttaa taaatacatt agtgagaatg aaacagtaaa
     7441 tataaataat atagtaaata acattctaga cgaatacgaa tcgtccttga aattcgtgtc
     7501 aattatgtat ctattagcta taggtactaa tgattgtatt acatacaata atgctgttac
     7561 aaaaaataaa atccctagct tattcctata cttaaaaaaa tactttaaaa caggcgactt
     7621 cttattatct ttacgagaca taaagctatc taacttttta aatgttaaaa tgatatttga
     7681 ataatgcctt tcaaattcac ttattgacat tctctgcctg ccttttgcag gatctaaaat
     7741 ataaaacttg tttttactaa ttttttcaag aataataaaa tgagaactct cccagaagca
     7801 aatgagtggg aaactgagcg gttttaaatc tcttaccgaa gctttaaaag catgagaact
     7861 tatattaaaa tctcctaaaa ctttacttat agataggaga gaatatccag atctggatga
     7921 tgggtagatt tcacgtagtt catttaaaga aatctcatat ttaaaatagt tcaatatcat
     7981 ggcacagcat gctaatccac attctgaatt ttccatttga tatatcattg gaattttcac
     8041 aatacttcct ccttgttcaa aataaagtcg ataatttctt cttgtctaaa atctactaat
     8101 ttctttagat acttaatctt ttctaaatat ttattatttt tcgagtaaat atagtttgac
     8161 aaggtaaaaa caacttcttc taaagataag ttctgtggaa taatccaatc agaagattta
     8221 tgtagtaatt tatagtactc atggataata ttttcctgaa tatttgaatc aaaaacttca
     8281 tgattagcaa ttgtaaatgc tgacccttca cctttcactt caaagtaaag gtttatcaaa
     8341 catttttcaa attttgaaaa aaaagatttt tctttagagg ttaattttgc aaaatcgtcg
     8401 attgttatat aaggattatt atagagactg ttcgcaaaga atctctgata tgtttttgaa
     8461 tcttttgaat acaaaactat ctctctaata gcattgccat ctgttccatc aattggtaaa
     8521 cataccgtaa ctagaaaaag aattatattc aaaataaaaa attctgatgc gtacggcaca
     8581 aatcccaaaa gtgctaatat tgcgacaatt aggttagctc cacctccccc aaagaagtag
     8641 aacaccaaat tcctatcact atttttttca ttagtaatgt ttctattact catttgacaa
     8701 taaccgaatg ctaataacac tggaaatttg aaatatattt tttttctgaa atagaagaaa
     8761 aagggagtag caagcatctc tagtttataa gataaacatc ttcccactaa aaaatgacct
     8821 agttcatgta atgtaattga tattaacgaa attaaaatca atcgaaaata atagattaat
     8881 gaatcatttg gaaaaattat caataatagg aacaataacg gaatcaaaca taaatatatg
     8941 acagagttat ttaatatttt caacataata ccattcctct aaactattag cttcaaaaag
     9001 gcgttttttc tcccaataca tcttctcaaa atgttcggaa tcataatttt ctaaaattaa
     9061 ttttaatgtc tggtaagctc tttcttgata atccgttgtt ttgtacttaa ttttcccttc
     9121 aagtacatct tcaattttat aagttgcctc catcaactga gcctctgcaa tatctttgag
     9181 tgaattggta attgaaactt ggtgtaatat ctgtcctccc atatatgaaa atatatctct
     9241 aagatattct gacacattat cagagccgtt actctcagca acatctaatg ttacaacaaa
     9301 ctttccagct aatcgaaaaa gatggctcca ccccccaatc ctttcaataa agttttttgt
     9361 gtccacagat acgttttgta aatatacagg agaagagata attataatat cagactctaa
     9421 taactctttt tttataacac ctccatcatc agcattactt tgcctatcaa ttcctttctt
     9481 aaacaactct tctgaatcag aattagatat ttctagctct gaattgaaag gtgtcctgaa
     9541 agatatatca acattatttc tactagaaat gatacttgaa agtctcttag tatactctaa
     9601 agtcttagag ttatgatttc gcactcctgc atatataaat attttattca ttttaattca
     9661 tcctctcaat ttgaatttag tagatttttc aagatagtat ggtacaaaaa cagacttttg
     9721 ttgactcaca ttattacata tgttttgtat taaaccaaaa tcaatactat ttttggagta
     9781 attttgattt tagtttaaaa tcatttctat aacagtagca tatacctcaa gccgtttagc
     9841 aattagaata gaaccttcct ttattatatt attatctcaa cgaaaagcta cactattaaa
     9901 aatattttat agaattacat attaaactag tcaatcttgg tatttttata ttgcttaatg
     9961 agtggacacc tctattttag aaacaaaact ataaattaag ctagatttca agtaatgagg
    10021 ggataactat ctttttgtca ttctgattca gtgcgatata ccttaaaaaa gtataagcaa
    10081 taccagtcac acctgtatac aaagaaaaat ctgggaaatt gcttgtttgg acgatacgat
    10141 actctccttc ttttgattta ttcattacaa cactacacaa taaagactcc aattccatac
    10201 tagtatccat ttctttcatg tagtcgatgt aaaaatttat tatggccata cttccatggc
    10261 aaaatgtatc attatctaaa ctagctacaa ttccctctgg aacactttgg ggatgattaa
    10321 ctaatgtccc aaattctcca ctacaccact tcaaagaatg aattttgatt ttctccctag
    10381 gaactagttg taaaattaat tctttatatt ttttaagtct tgttacttta taaatatttt
    10441 ttaatgtaaa aattacacct gatagtccat ggccaaaact atatccaaaa ttactattat
    10501 ctctctcgct tacatcatta tatagcgtat cacctaaact taatactagc cttagaacac
    10561 gttccttctc tattcctctc ctataatatc ttaccagtgt attaattaaa ggtagaagac
    10621 cattaatata gtcagacttg tttgaaacac ttgcaaaatc agtcttttca agctcagtta
    10681 aaacactctt tatataattt aagcatgcga gagtatttgt atcgtaatcc tctataatgg
    10741 atagaacaat gaaatatcct atatccccag ttaaaccaaa tgtggtctta gataaagaaa
    10801 cagatggcgg aattgcagat aacattttat tgtacagttg agtatatgat gatttatctt
    10861 tcaataattt tacatagtac ataaacagta atattccagc tctaccccta tacatatcat
    10921 tacccgtttg ttcaagacac catttagaac ctttaaaatt aacaggtata ctccaaattg
    10981 gatattcgtc ataaatatta ttaataacca aagagtctgc aatattttct acttcattat
    11041 gcagaatagt aactaaactt tcatttggga gtttttttct attagataag tttaatttat
    11101 atcctttttt tcgctgatca aagcttggaa aataaatttc aatgatatca agttgctttt
    11161 ctaaattttc caaattatta ttaggtaaat atttcataaa atagtcatat ccagaaaatt
    11221 gatgtaggga aataaaatga tttccaaaat catcgtagat ttcattgata tttgtatctg
    11281 tataaaaaat cggaatatct aataacctca tttgttcaca ttcgcttgct acaatacctt
    11341 gattagaaaa cttattgctc cagagatttt ccaatgcttt ttctctatct aacatttctt
    11401 cataaaaatc aggatgatat aaaaaagata gtactgaagc atagctattt gtgtctctaa
    11461 aaagtaccct tgtctttaaa ccatacaagt ttgcttttaa tagcatttta aattcttctg
    11521 ttttatttaa ctcttcaaat atcagataaa aatccctaaa accttttttg aaatctttta
    11581 tatacttatc aaattctata tcaccatccc gaacaggcag gtttttccca ccttcaaaat
    11641 caattttccc aatatcaaac tttaccttat cagtatttaa attaattaaa acttgaccat
    11701 taaaagcatc cttcttaaaa tttcctgtaa gagcactcat ctcaacatca agaccatcct
    11761 ccctttttac tccctctgtt ggaagaagca aagttcgagt caccctgtga aacagggtat
    11821 ccagcaaact ctgaccagtt ttatcatcaa atagaggttg ctgtaacatt gtttcaaagt
    11881 ctattattac aggcatatct ccataggaaa ttaaattttc aaaatgtata tcactcccat
    11941 taaataaata tataaatgct aaaagcacac caaaattata ataatattca ggtaaatttt
    12001 tcttttgctc tagaggtaga taatcaataa attcttcata gctgtgatcc gaataagcaa
    12061 tagttcgagg tattcttatc ctaatttttt catcaacctt tcggatatac tcagcaatag
    12121 tatttagtga gttattgatt attaaatttt taggcttgta aacaattttc gcgtcatcaa
    12181 agaagagtat caaaacagtt tttccttggc tgtgtgtatc accctttcca aattttatat
    12241 catttaattt cccccttagc cctaattctt cttctagcac actaaaatca ttttctaaat
    12301 ttgataaaat ttctataaaa taagtataga accgaagaca agactccgat atttgcctca
    12361 gtaaaacggg atatttgtta taaaaattta atatattctc ttccttgtca aacaatgtta
    12421 taaaatattt gtaccgttgc tgctccgatt ccccttcaag taaacctttt tcacgcaatg
    12481 aatttatctc taaaaccaaa ggtttaacaa tccaaggata gattaaatct tctaaataaa
    12541 atactagaga ggaaaaaata tttccattct tgtcaatcca ctcgtattct ttattctcta
    12601 gataattatt gattaattta agcaaattaa taataaaggg ttccaaaatt ctagaaaaat
    12661 ctttcttaaa attaattctt tggggatgtt ttctaaatat ttcaaatgaa ccctccgcaa
    12721 atttatacca ttccgaattt ttggcatatt ctgaatatag tcttatctgt tcctcggtat
    12781 aatcatagtt cacagtgtta gaaaatattt ttttattgta attatttaat ttcaacattt
    12841 cttcaaaagt tttttcagaa ataattgaca ttgtagaacg ccaattattt aatgaaaagt
    12901 tatttaagga attatcattt cgttcagata atatttgata tctttcctta ataaacaatg
    12961 ttttatgcac atttttaatt ttatatttca tttacttacc tcaaacctat acgacttact
    13021 attgttttaa aaaaaaacct ctctcaaaat tattagttac gagagaggaa aataaagagc
    13081 aacttttatt tttaaaattg aatattttat tttttcttgt tgtctttgcc acaacgagtc
    13141 tgagctgacc ccaaatatga tgcaataaaa cttaatgtag cagaacatat aattgttgat
    13201 ctagggtcag caccatctgt gccaccataa accaattgca tttcttcaag agataattct
    13261 ttcaaactct ttccgattac aaaatcattt ttcattttaa tttaccccaa acaatcatta
    13321 ttgtagctaa ctagcccccc aataccagaa acagctgcac taatgcatac tttcgagcta
    13381 gctgcagctg atttcaaaat aataggagta ggcgtccaac gtggctctgc accatcagat
    13441 gcaccataaa ttaaactcat ttcatcagca gacaatgatt ttaaactttt tccacaaaat
    13501 ttttcgtttg aattaaagtt ggtcataagt aataactcct ccttataaaa agttaaataa
    13561 gttgctctat atttttcgtt ttttcagata aattataatt ctctcattct cgtgcaaaat
    13621 atcgggtttt aatccgcctt cccaacatca agaccattgg acttcttttg cgattgcact
    13681 cgaatctcca attgtttatt cttctgaata aactgttggt aaggaattgt attactaaac
    13741 ataaaaacac ctagcaatgc aaatgtaact aattttttaa ttccacgttt ttttctcatg
    13801 caatgaaacc cctttctttt tccttgtttt tattctaaca gatatatttt atttagtcaa
    13861 gtatttttat gtaattttta actttttttt ttgtttatta ccataaagaa ttatttattc
    13921 ctttaacttg ctattttgaa ctaaaaactt tataatgaaa ttaagcaaat aggaaggttt
    13981 attatcttta atgaatacac tcgcagagaa attcagattg aaaagaaaag agttgagact
    14041 ctcccaacaa actcttgcag aaggaatttg tgaacaaagc cagattagta aaattgaaag
    14101 aggtcatttt attccctccg cagacttgtt attcaaactc tctcaacgac ttgaagtccc
    14161 tttggattac tttttcaatg aacaaatcga agttaagtct aacctctcta atttcaaaca
    14221 tctatctgct cgcctattag atgacagaaa ttatgacgat ttagaatatc tttataaaat
    14281 agaggtagaa cgaagcactt ttctaacatt agaagaccga acttaccttg aatggattaa
    14341 atctataatt gacttctatc aatatgacag taagtgtgag gcaatttcgt cattggaaaa
    14401 tatattatta aaagtctctt caaatactct gatttattta aaggcgttga atactctatc
    14461 taatttctat tccttagtgg gtcgtgaaca agaatatgag gcaaactact ctcatttaat
    14521 agagttgtat cagacaaaaa atttggacca tcaagagttt ttatttggct acatcagagt
    14581 tcgttacaac tacgctcact acctagtatc aaaggaaaaa tataatgaag ccatccaaga
    14641 agctcttgaa acgattgaac tctgtaaaca aagacagaca agctaccaat tggctcctct
    14701 acttattctt gtaggaaatg ctggagccaa atttctagac agagaacaag tcaaaaatta
    14761 ttatatagaa gcaagagagt tatgtaagat ttataacaat cctttaatgt tgatgaagat
    14821 agaaaattat ttgaaggaac tagatactgt ttagttaatc ttgacattat agtttttctg
    14881 aaacgttaaa taacctgtaa ggctgatagt tagattaata ctatcagcct tataattatg
    14941 tgactctgag tccgtctcgc tccgtgaggt gcgagacaaa acaaccaccc gtttgacgga
    15001 ttttcatgat ttcaaattta tattcttcga aaatctcttc aaatcacgtc agctctatct
    15061 gcaatctcaa aacactgttt tgagcaacct gtggctagct acctagtttg atctttgatt
    15121 ttcattgagt attagtctct agtgtttgtt tagcgtctta aagagacatt tgagaagatt
    15181 agaaacagtt ctctcttttc tcctagtata atgattggta ggaagggaga gagaagatga
    15241 aatcaatgag aatcttattt ttgttagctt taattcaaat cagtttgagt agctgtttcc
    15301 tatggaagga atgcatcttg tcctttaaac aaagtacagc ttttttcatc ggaagcatgg
    15361 ttttcgtttc aggaatctgt gctggagtaa attatcttta tacccgtaag caagaagtcc
    15421 atagtgtcct agccagtaag aagtcggtga agctttttta cagtatgtta ctcttaatta
    15481 atttgttagg agctgttctt gttttgtcag ataacttgtt catcaaaaat acgctgcagc
    15541 aagaattagt tgacttttta ttgccatcct tctttttcct atttgggcta gatttgctga
    15601 tttttttacc cttgaaaaaa tacgtgcgcg attttcttgc tatgctggac agaaaaaaga
    15661 cagtgttggt gactatttta gcaacacttc ttttcttaag aaatccaatg accattgtct
    15721 cacttctgat ttatattgga ctgggcttgt tttttgcagc ctatcttgtc ccaaattcgg
    15781 ttaagaagga agtttccttt tatggtcata ttttccgaga tcttgtattg gtcattgtta
    15841 cgctcatttt cttttagaga aagcctgttt tttatggatg ttatgatgat aagtttagta
    15901 ggaaaataga cacaaaagaa aagtttttgg tataataaga gtatgtacac aaaaaatgaa
    15961 gaagagttgc aagccttagg ggagcgtttg ggccatctat tagcaaagaa tgatgtttta
    16021 atcttaactg gagaactggg tgcaggtaaa acgaccttta ctaaaggact tgcaaaagga
    16081 ttacagattt ctcaaatgat taaaagtccc acctatacta tcgtgagaga gtatgaaggt
    16141 cgacttccac tttatcacct agatgtttat cgtattgaag gagatgctga ttctatcgac
    16201 ttggatgagt ttatctttgg tggcggcgtg actgttattg agtggggaaa tctcttagga
    16261 gatgccttgc cagatgctta tttagaattg gaaattctaa aagaagcaga tggacgccgt
    16321 ttaaattttc aggcaaaggg tttgcgtgct gagaaattgt tagaggagct tcaatatgga
    16381 gtatgaattg ctcattaggg aagcagagcc caaagatgca gctgaattag tggccttttt
    16441 aaatcgtgtg agtttggaga cagactttac cagcctagac ggagatggta ttctcttgac
    16501 tagtgaggag atggaaatat tcctcaacaa gcaagctagt tcggacaatc agataacctt
    16561 acttgcattc ttaaatggca aaattgctgg tattgtaaat attacagctg atcagcgtaa
    16621 gagagtccgt catattggag atctcttcat tgtgattgga aaaagatatt ggaataatgg
    16681 cttgggaagt ttgttgctag aagaagcgat agagtgggca caagcaagtg gcattctgcg
    16741 tcgtctccaa ctgactgtcc aaactcgtaa tcaagcagca gtccatcttt atcaaaagca
    16801 tggctttgtc attgaaggta gccaagagcg tggggcatat atagaagaag ggaaatttat
    16861 cgatgtttac ttgatgggta aactgatagg ttagtagaaa tatggttaaa aaaattattg
    16921 gaatggtgct agctttactt tctgtaactg tagtaggagt aggtgttttt gcttatacta
    16981 tttatcaaca agggacagaa accttagcta aaacctataa aaaaatcggt gaagaaacca
    17041 aggttattga agcgactgaa cctctaacca ttctgttaat gggagtggac accggaaatg
    17101 ttgaacgaac tgaaacttgg gtcggtagaa gtgatagcat gatcttgatg acagtgaatc
    17161 ctaaaacgaa aaaaacaaca atgatgagtt tagagcggga tattctgacg cgcattgaat
    17221 cagggaatgg tcaggctcat gaagcgaaac tgaactcagc atatgcagat ggtggagcag
    17281 agcttgctat agaaaccatt caaaaaatga tgaatatcca tattgatcgc tatgtgatgg
    17341 tcaatatgag agggttgcaa aaattagtgg atgcagtagg aggtattaca gtcaataata
    17401 tcctaggttt cccaatttct atcagtgacc aagaagaatt taataccatt tctatcggtg
    17461 ttggggagca acatattggg ggagaagaag ccctagtcta tgcacgaatg cgttaccaag
    17521 atcctgaggg ggattatggt cgtcaaaaac gtcaacgtga agttattcaa aaagtcatgg
    17581 aaaaagctct cagtttaaat agcattggtc attatcaaga gattctaaaa gctttgagtg
    17641 acaatatgca gaccaatatt gatttgtctg caaaaagtat ccctaacttg ctaggctata
    17701 aagattcatt taaaaccatt gaaactcagc agttgcaggg tgaaggagag atacttcaag
    17761 gtgtttctta ccagattgtt tcgagagcac atatgttgga aatgcaaaat atactccgac
    17821 gttctttggg acaagaagaa gttactcagc ttgaaaccaa tgcggtttta tttgaagatt
    17881 tatttggcag agcacctgtt ggtgatgaag ataattaact tttgatacaa ataaaaaaat
    17941 caatcgtagg aaaattcctg cgattttttc aaaaaaatac gaatagatag gtaggaggaa
    18001 acatgaaagc agaaatcatt gctgttggaa cagagatttt gacaggacag attgtcaaca
    18061 ccaatgccca gtttttgtcg gaaaaactag ctgagattgg ggtagatgta tattttcaga
    18121 cggctgtagg agacaatgaa gttcgtctct tgtctttgct tgagattgcc agtcaacgta
    18181 gcagtctggt gattttgaca ggcggtttgg ggccaactga ggacgaccta accaaacaaa
    18241 ccctagctaa atttttaggg aaagcattag tctttgatcc tcaggctcag gagaagttgg
    18301 atatcttttt tgccctgcga ccagactatg cccgaacacc gaataacgaa agacaagctc
    18361 aaattgtaga aggagcgatt ccactgccaa acgaaacagg actggctgtt ggaggaaaat
    18421 tagaagtaga cggagtgacc tatgtcgtcc ttccaggtcc gccaagtgaa ttgaaaccca
    18481 tggtcttaaa ccaacttcta cccaagttga tgacagggag caagctgtat tcccgagttc
    18541 ttcgtttctt tgggattggc gagagccagt tggttacgat tttggctgat ttaattgata
    18601 atcagatcga tcctaccttg gccccttatg ccaagacagg agaagtcact ctacgtctgt
    18661 caacaaaggc tagcagtcaa gaagaggcga atcaagcgct ggatatcttg gaaaatcaaa
    18721 tcttggactg ccagactttc gaaggaattt gtttacgaga cttttgctat ggttatgggg
    18781 aagaaactag tttagccagc attgtggtag aagaactgaa aaggcaaggg aaaaccatcg
    18841 cggctgcaga gagtttgacg gcaggtcttt tccaagctac cgtggcgaat ttttctggag
    18901 tttcaagtat atttaagggt ggttttgtga cctatagctt ggaggaaaaa tcaaggatgt
    18961 tggatattcc tgccaagaat ttggaagaac atggtgtggt gtctgaattt acagctcaga
    19021 agatggctga gcaggcacga agcaagaccc agtctgattt tggaattagt ttgactggag
    19081 tggcaggacc agatagccta gaaggacacc cagttgggac agtcttcata ggcttggcgc
    19141 aagatcaagg aactgaggtt atcaaggtta atattggagg cagaagccga gcagacgtac
    19201 gtcacattgc ggttatgcat gcctttaacc tagttcgcaa ggctttatta agtgactaac
    19261 ttttgatata atagtagata ggtctgagga tcattagaat gtaggagaat agaatggcga
    19321 aaaaaccaaa aaaattagaa gaaatttcaa aaaaatttgg ggcagaacgt gaaaaggcct
    19381 tgaatgacgc tcttaaattg attgagaaag actttggtaa aggatcaatc atgcgtttgg
    19441 gtgaacgtgc ggagcaaaag gtgcaagtga tgagctcagg ttctttagct cttgacattg
    19501 cccttggctc aggtggttat cctaagggac gtatcatcga aatctatggc ccagagtcat
    19561 ctggtaagac aacggttgcc cttcatgcag ttgcacaagc gcaaaaagaa ggtgggattg
    19621 ctgcctttat cgatgcggaa catgcccttg atccagctta tgctgcggcc cttggtgtca
    19681 atattgacga attgctcttg tctcaaccag actcaggaga gcaaggtctt gaaattgcgg
    19741 gaaaattgat tgactcaggt gcagttgatc ttgtcgtagt cgactcagtt gctgcccttg
    19801 ttcctcgtgc ggaaattgat ggagatatcg gagatagcca tgttggtttg caggctcgta
    19861 tgatgagcca ggccatgcgt aaacttggcg cctctatcaa taaaaccaaa acaattgcca
    19921 tttttatcaa ccaattgcgt gaaaaagttg gagtgatgtt tggaaatcca gaaacaacac
    19981 cgggcggacg tgctttgaaa ttctatgctt cagtccgctt ggatgttcgt ggtaatacac
    20041 aaattaaggg aactggtgac caaaaagaaa ccaatgtcgg taaagaaact aagattaagg
    20101 ttgtaaaaaa taaggtagct ccaccgttta aggaagccgt agttgaaatt atgtacggag
    20161 aaggaatttc taagactggt gagcttttga agattgcaag cgatttggat attatcaaaa
    20221 aagcaggggc ttggtattct tacaaagatg aaaaaattgg gcaaggttct gagaatgcta
    20281 agaaatactt ggcagagcac ccagaaatct ttgatgaaat tgataagcaa gtccgttcta
    20341 aatttggctt gattgatgga gaagaagttt cagaacaaga tactgaaaac aaaaaagatg
    20401 agccaaagaa agaagaagca gtgaatgaag aagttacgct tgacttaggc gatgaacttg
    20461 aaatcgaaat tgaagaataa gctgttaaag cagtggagaa atccgctact ttttcgattt
    20521 ttgattcaag tttttagatt atatatagta gcttgaaata agatatgaac aactttatta
    20581 ggaaagtcaa attaatttct agaaatgttt tagcagctac agcgtactat tccaaactca
    20641 accaattata atagatcgaa actagaatag tacacatcta cttctaaaat attgttaaaa
    20701 atcgatttga ctgtccttat ttcattccgc tatatatagt ttgctgtttc ttgtcgctcc
    20761 tctggaaagc tgatataata gctttatgaa taaaaaacga acagtggacc tgatacatgg
    20821 tccgattctt ccctcgctct taagcttcgc cttcccaatc ttgctatcaa atatttttca
    20881 acagctctat aacactgctg atgtcttgat tattggacga tttcttggtc aagaatcctt
    20941 ggctgcagta ggagcgacga cagcgatttt tgacctgatt gtaggtttta cacttggtgt
    21001 tggcaatggt atggggattg tcatcgctcg ttattatggg gctcggaatt tcactaaaat
    21061 caaggaagca gtagcagcca cctggatttt aggtgttctt ttgagcattc tagttatgtt
    21121 gctgggcttt cttggcttgt atcctctctt gcaatactta gatactcctg cagaaattct
    21181 tcctcaatct tatcaatata tttctatgat tgtgacctgt gtaggtgtca gctttgctta
    21241 taatcttttt gcaggcttgt tgcggtctat tggtgacagt ctagcagccc tgggatttct
    21301 gattttctct gccttggtta atgtggttct ggatctctat tttattacgc aattgcatct
    21361 gggagttcaa tccgcaggac ttgctaccat tatttcgcaa ggtttatcag cggttctctg
    21421 cttttattat attcgtaaaa gtgtgccaga actcttgcca cagtttaaac atttcaaatg
    21481 ggacaaaagc ttgtacgcgg atctcttgga gcaaggtttg gctatgggct tgatgagttc
    21541 aattgtatct atcggcagtg tgattttaca gtcttctgtt aatacatttg gtgcagtgat
    21601 tattagtgcc cagacggcag ctcgacgcat tatgaccttt gcccttcttc ctatgaccgc
    21661 tatttctgca tcaatgacga cctttgcttc tcagaatcta ggagctaagc gacctgaccg
    21721 cattgttcaa ggtcttcgaa tcggcagtcg tttaagtata tcctgggcag tttttgtttg
    21781 tattttcctc ttttttgcca gtccagcctt ggtttccttc ttggctagtt cgacagatgg
    21841 ttacttgata gaaaatggaa gtctctatct gcaaattagt tcagcctttt atcccatttt
    21901 gagcctcttg ttgatttatc gcaattgctt gcagggcttg gggcagaaga tccttcctct
    21961 agtttctagc tttattgaac taatcggaaa aatcgttttt gtggttttga ttattccttg
    22021 ggcaggatat aagggtgtta tcctttgtga acctcttatc tgggttgcca tgacagttca
    22081 actgtacttc tcactattcc gtcatccctt gataaaagaa ggaaaggcaa ttttggcaac
    22141 caaagtgcaa tcctagttgg atttactgaa taaaatccat ttcctctagt gaaaatcgaa
    22201 aaaacttgtg ttctcttctt tagtttggtg ttgaaaatag tttaacagac ttttgacttc
    22261 ttttatatga tataataaag tatagtattt atgaaaagga catatagaga ctgtaaaaat
    22321 atacttttga aaagcttttt agtctggggt gttattgtag atagaatgca gaccttgtca
    22381 gtcctattta cagtgtcaaa atagtgcgtt ttgaagttct atctacaagc ctaatcgtga
    22441 ctaagattgt cttctttgta aggtagaaat aaaggagttt ctggttctgg attgtaaaaa
    22501 atgagttgtt ttaattgata aggagtagaa tatggaaatt aatgtgagta aattaagaac
    22561 agatttgcct caagtcggcg tgcaaccata taggcaagta cacgcacact caactgggaa
    22621 tccgcattca accgtacaga atgaagcgga ttatcactgg cggaaagacc cagaattagg
    22681 ttttttctcg cacattgttg ggaacggttg catcatgcag gtaggacctg ttgataatgg
    22741 tgcctgggac gttgggggcg gttggaatgc tgagacctat gcagcggttg aactgattga
    22801 aagccattca accaaagaag agttcatgac ggactaccgc ctttatatcg aactcttacg
    22861 caatctagca gatgaagcag gtttgccgaa aacgcttgat acagggagtt tagctggaat
    22921 taaaacgcac gagtattgca cgaataacca accaaacaac cactcagacc acgttgaccc
    22981 ttatccatat c
//
