Select genomic region:
Overview
1.1
5.1
5.2
8.1
10.1
15.1
22.1
25.1
33.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CFVJ01000001.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 1 | 6,208 |

NZ_CFVJ01000005.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | RiPP-like | 29,816 | 40,112 |
Region 5.2 | lanthipeptide-class-ii | 64,005 | 86,995 |

NZ_CFVJ01000008.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | RiPP-like | 52,000 | 62,866 |

NZ_CFVJ01000010.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | RiPP-like | 37,093 | 47,392 |

NZ_CFVJ01000015.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | RiPP-like | 4,478 | 22,414 |

NZ_CFVJ01000022.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | T3PKS | 1 | 21,757 |

NZ_CFVJ01000025.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 25.1 | RiPP-like | 19,905 | 26,695 |

NZ_CFVJ01000033.1 (Streptococcus pneumoniae)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 33.1 | terpene-precursor | 1 | 16,543 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 1 | 6,208 |
Region 5.1 | RiPP-like | 29,816 | 40,112 |
Region 5.2 | lanthipeptide-class-ii | 64,005 | 86,995 |
Region 8.1 | RiPP-like | 52,000 | 62,866 |
Region 10.1 | RiPP-like | 37,093 | 47,392 |
Region 15.1 | RiPP-like | 4,478 | 22,414 |
Region 22.1 | T3PKS | 1 | 21,757 |
Region 25.1 | RiPP-like | 19,905 | 26,695 |
Region 33.1 | terpene-precursor | 1 | 16,543 |

No secondary metabolite regions were found in these records:
  NZ_CFVJ01000002.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000003.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000004.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000006.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000007.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000009.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000011.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000012.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000013.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000014.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000016.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000017.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000018.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000019.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000020.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000021.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000023.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000024.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000026.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000027.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000028.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000029.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000030.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000031.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000032.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000034.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000035.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000036.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000037.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000038.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000039.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000040.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000041.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000042.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000043.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000044.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000045.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000046.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000047.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000048.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000049.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000050.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000051.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000052.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000053.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000054.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000055.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000056.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000057.1 (Streptococcus pneumoniae)
  NZ_CFVJ01000058.1 (Streptococcus pneumoniae)

Compact view
NZ_CFVJ01000001.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 6,208 nt. (total: 6,208 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000504.5 |  | 0.41 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000500.5 |  | 0.40 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001576.3 |  | 0.39 | ribosomal | divamide A | Prochloron didemni
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000504.5 |  | 0.41 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000500.5 |  | 0.40 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001576.3 |  | 0.39 | ribosomal | divamide A | Prochloron didemni
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
Additional weak hits (5):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.88 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.57 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.88 out of 31.73
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_CFVJ01000005.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 29,816 - 40,112 nt. (total: 10,297 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.36 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002698.2 |  | 0.35 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000500.5 |  | 0.35 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.36 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002698.2 |  | 0.35 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000500.5 |  | 0.35 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
Additional weak hits (1):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.05 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_CFVJ01000005.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 64,005 - 86,995 nt. (total: 22,991 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
AP598_RS03240: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
AP598_RS03260: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.60 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.51 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.49 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.60 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.51 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.49 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for AP598_RS03260

AP598_RS03265
Leader:
MKNDFVIGKSLKELSLEEMQLVYGG
Core:
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
Core with dehydrations:
Dhb D G A D P R Dha Dhb I I Cys Dha A Dhb L Dha F I A Dha Y L G Dha A Q Dhb R Cys G K D N K K K

#### antiSMASH-DB 4.0 matches for AP598_RS03265

100.0%
NC_003028.3 and 45 others:
NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptide NZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptide NZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptide NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptide NZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptide NZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide
Lanthipeptides: SP_RS09795_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
97.3%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06305_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S+I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S S I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
97.3%
NZ_NAOJ01000022.1:
Lanthipeptides: B5K31_RS08015_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S T I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S T T I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
with 20 more sequence matches
Only the first 10 are displayed here.
70.3%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00310_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
A D R S T I C S A +S F I A+Y L G S A T C G K D N K K
5
A D V R S T P I C S A G I S F I A T Y L G S A A T N C G K D N K K
37
59.5%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23820_lanthipeptide
2
D G A D P--R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
D G D R S T+I C S F I S Y L S A +C G K N K K
1
D G M D V E V R S T L I C G V G A S F I G S Y L A S A A F K C G K K N K K
37
56.8%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24360_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A Q R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A Q Y R C G K D N K G K
35
56.8%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide
Lanthipeptides: KNQ12_RS14670_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
D R S+++C S A L S F+ S Y L S A +C G K D N K K
4
V D V R S S L V C S A L L S F V G S Y L A S A G L K C G K D N K K
36
56.8%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26050_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A Q R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A Q F R C G K D N K G K
35
55.3%
NZ_LWAG01000079.1:
Lanthipeptides: A4R27_RS25235_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
A+ R S T+I C A +S I S Y L S A +C G K D N K K
5
A E A R S T L I C G A G I S L I G S Y L A S A A F K C G K D N K G K
38
54.1%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24355_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A+ R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A E F R C G K D N K G K
35
51.4%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08665_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K
35
A+ R S T++C +S F+A S Y L S A +C G K D N K
5
A E V R S T L L C G M G I S F V A S Y L A S A A F K C G K D N K
36
51.4%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17790_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A+ +C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A E F K C G K D N K G K
35
48.6%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27545_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K
35
G P R+T + S F+A S Y+ S A+ R C G K D N K
2
G V T P R T T P A T T L L A S F V A S Y I A S A E F R C G K D N K
34
AP598_RS03270
Leader:
MTNFNSNEKFCGKSLKSLSADEMSLIYGA
Core:
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
Core with dehydrations:
Dha D G A E P R W Dhb P Dhb P I I L K Dha A A A Dha Dha K V Cys I Dha A A V Dha G I G G L V Dha Y N N D Cys L G

#### antiSMASH-DB 4.0 matches for AP598_RS03270

100.0%
NC_003028.3 and 39 others:
NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptide NZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide
Lanthipeptides: SP_RS09790_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
97.8%
NZ_CP035244.1 and 3 others:
NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide
Lanthipeptides: EQH36_RS09100_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P I I L K S A A A S S K+C I S A A V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P I I L K S A A A S S K I C I S A A V S G I G G L V S Y N N D C L G
45
95.6%
NZ_JALDUX010000010.1:
Lanthipeptides: M1F92_RS09530_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P+I L K S A A A S S K V C I S A V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
with 20 more sequence matches
Only the first 10 are displayed here.
91.1%
NZ_JAMYJM010000002.1:
Lanthipeptides: NKE69_RS04880_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P I L K S A A S S K V C I S A V S G I G G+V S Y N N D C L G
1
S D G A E P R W T P T P F I L K S A T A S S K V C I S A V V S G I G G I V S Y N N D C L G
45
84.4%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06300_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
S D G A E P W T P T P I L K S A A S S K V C I S A +S G I G G+ S Y N N D C L G
1
S D G A E P L W T P T P T I L K S A A R S S K V C I S A I I S G I G G I F S Y N N D C L G
45
77.8%
NZ_CMKL01000017.1:
Lanthipeptides: AD734_RS09115_lanthipeptide
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G
35
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G
35
54.3%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14400_lanthipeptide
5
E P R W T P T--P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
E P R T P T P I + S S K V C+S S I G G+ S+N N D C L G
4
E P R A T P T I V P A I S A A V R T S S K V C L S L V A S A I G G I A S H N N D C L G
46
54.3%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08660_lanthipeptide
5
E P R W T P T P I--I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
+P R T P T + I++S A S S K V C I S A S I G+V S N +C L G
4
D P R A T P T I V A S I I R S V A Q S S K V C I S A V G S A I S G I V S N N K N C L G
46
53.3%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
5
E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
E P T P I L +A S S K C+ A+S I G L V S Y N D C L G
5
E P H T T P---I L S A A T K S S K K C L-G A I S A I S G L V S Y N K D C L G
41
51.1%
NZ_LWAG01000079.1:
Lanthipeptides: A4R27_RS25230_lanthipeptide
5
E P R W T P T P I I L K S A A A S S-K V C I S A A V S G I G G L V S Y N N D C L G
45
+P R W T P ++A A S K+C I S A S I G G+V S Y N +C G
4
D P R W T P I A S A A I N S A A R S S K I C I S A V G S A I G G I V S Y N K N C A G
45
48.9%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
5
E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
E P R T P I+ + S S K C I S A S I G++S+N D C L G
4
E P R G T P A T I V-S A V T R S S K P C I S A I G S A I S G I I S H N K D C L G
43
48.9%
NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
3
G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
G + R P T I++ + A S S K C+S V S I G L+S Y N D C+G
2
G V D T R T H P T V I V V--S R A S S K A C M S G-V S A I S G L L S Y N K D C I G
41
46.7%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00305_lanthipeptide
4
A E P R W T P-T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
A+P R W T P +L + S+++C I S S I G+V S+N D C L G
3
A D P R W T P A V S A V L S A V G R S T R L C I S G I G S A I S G I V S H N K D C L G
45

#### MIBiG 4.0 matches for AP598_RS03270

8.9%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
11
T P I I L K S A A A S S K V C I
26
T P + + S +C+
5
T P T V A Q F V I Q G S T I C L
20
allorf_65899_66006
Leader:
MTISLSRSVRCETKKTPAM
Core:
R V C V E G Y T K K T P N A I Q
Core with dehydrations:
R V Cys V E G Y Dhb K K Dhb P N A I Q

#### antiSMASH-DB 4.0 matches for allorf_65899_66006

100.0%
NC_003028.3 and 9 others:
NC_003098.1 Lanthipeptides: allorf_1743556_1743663_lanthipeptide NC_012466.1 Lanthipeptides: allorf_1823226_1823333_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: allorf_65899_66006_lanthipeptide NZ_CP082820.1 Lanthipeptides: allorf_1783059_1783166_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: allorf_46146_46253_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: allorf_046199_046306_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: allorf_00109_00216_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: allorf_46811_46918_lanthipeptide NZ_LR216049.1 Lanthipeptides: allorf_1766843_1766950_lanthipeptide
Lanthipeptides: allorf_1861890_1861997_lanthipeptide
1
R V C V E G Y T K K T P N A I Q
16
R V C V E G Y T K K T P N A I Q
1
R V C V E G Y T K K T P N A I Q
16
38.1%
NC_012470.1 and 1 other:
NZ_CP078012.1 Lanthipeptides: allorf_1992325_1992417_lanthipeptide
Lanthipeptides: allorf_0874216_0874308_lanthipeptide
7
Y T K K T P N A I Q
16
Y K K T P N A+Q
5
Y Y K K T P N A L Q
14
33.3%
NZ_CP031443.1 and 4 others:
NZ_FWZD01000067.1 Lassopeptides: BACERE00177_RS21400_lassopeptide NZ_NTYE01000016.1 Lassopeptides: CN490_RS29030_lassopeptide NZ_NUEY01000038.1 Lassopeptides: CN888_RS28205_lassopeptide NZ_QOSD01000019.1 Lassopeptides: DN410_RS14275_lassopeptide
Lassopeptides: MLA2C4_RS19250_lassopeptide
6
G Y T K K T P N A I Q
16
G K T P+A I Q
1
G P G H K T P D A I Q
11
with 4 more sequence matches
28.6%
NZ_CAKJTI010000013.1 and 1 other:
NZ_JACYOF010000019.1 Lassopeptides: IGI01_RS27610_lassopeptide
Lassopeptides: LRP84_RS13300_lassopeptide
6
G Y T K K T P N A I Q
16
G K T P+A+Q
1
G P G H K T P D A V Q
11
28.6%
NZ_JALJRJ010000031.1:
Lassopeptides: OC439_RS28220_lassopeptide
3
C V E G Y T K K T P N A I
15
C E Y + P A I
7
C R E S Y V T Q K P R A I
19
28.6%
NZ_QQAY01000002.1:
Lassopeptides: DFR59_RS05045_lassopeptide
6
G Y T K K T P N A I Q
16
G K T P+A+Q
1
G P G K A T P D A V Q
11
23.8%
NZ_CM000754.1 and 19 others:
NZ_CP020723.1 Lassopeptides: B7P25_RS28625_lassopeptide NZ_CP023179.1 Lassopeptides: CK938_RS28520_lassopeptide NZ_CP032365.1 Lassopeptides: D4A37_RS18780_lassopeptide NZ_CP041063.1 Lassopeptides: FJM75_RS10710_lassopeptide NZ_CP085399.1 Lassopeptides: LIS81_RS18060_lassopeptide NZ_FMBE01000013.1 Lassopeptides: CCY88_RS31005_lassopeptide NZ_FMJI01000046.1 Lassopeptides: CCY61_RS30520_lassopeptide NZ_FMZR01000002.1 Lassopeptides: BLS53_RS31385_lassopeptide NZ_FTLZ01000002.1 Lassopeptides: BW973_RS28715_lassopeptide NZ_JAIEZS010000055.1 Lassopeptides: K0820_RS18465_lassopeptide NZ_JH791975.1 Lassopeptides: IEI_RS31960_lassopeptide NZ_JH792165.1 Lassopeptides: IIO_RS35460_lassopeptide NZ_JYPF01000002.1 Lassopeptides: TU50_RS30650_lassopeptide NZ_NUFG01000001.1 Lassopeptides: CN694_RS29875_lassopeptide NZ_NURJ01000008.1 Lassopeptides: COE89_RS29040_lassopeptide NZ_PIYQ01000023.1 Lassopeptides: CW365_RS28935_lassopeptide NZ_QOSC01000009.1 Lassopeptides: DN392_RS14315_lassopeptide NZ_VDNI01000012.1 Lassopeptides: FSV62_RS19525_lassopeptide NZ_WBPF01000005.1 Lassopeptides: F8162_RS06315_lassopeptide
Lassopeptides: BTHUR0009_RS30905_lassopeptide
10
K T P N A I Q
16
K T P+A+Q
5
K T P D A V Q
11

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.84 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06
Confidence: medium
Additional weak hits (4):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 23.43
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.04 out of 30.11
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

AP598_RS03265 - Class II
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 3741.0 Da
  Molecular weight: 3743.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3761.2 Da N = 1
    3779.2 Da N = 2
    3797.3 Da N = 3
    3815.3 Da N = 4
    3833.3 Da N = 5
    3851.3 Da N = 6
    3869.3 Da N = 7
AP598_RS03270 - Class II
  Cleavage pHMM score: -0.40
  RODEO score: 0
  Monoisotopic mass: 4313.2 Da
  Molecular weight: 4315.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4333.9 Da N = 1
    4351.9 Da N = 2
    4369.9 Da N = 3
    4387.9 Da N = 4
    4405.9 Da N = 5
    4424.0 Da N = 6
    4442.0 Da N = 7
allorf_65899_66006 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1769.9 Da
  Molecular weight: 1771.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1789.1 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CFVJ01000008.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 52,000 - 62,866 nt. (total: 10,867 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000535.4 |  | 0.40 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000506.4 |  | 0.40 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000511.5 |  | 0.39 | ribosomal | ericin S | Bacillus subtilis
BGC0000310.5 |  | 0.38 | NRPS | bacitracin | Bacillus licheniformis
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0002575.2 |  | 0.37 | ribosomal | cochonodin I | Streptococcus suis
BGC0000188.5 |  | 0.37 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001727.3 |  | 0.36 | ribosomal | paenilan | Paenibacillus polymyxa E681

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000535.4 |  | 0.40 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000506.4 |  | 0.40 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000511.5 |  | 0.39 | ribosomal | ericin S | Bacillus subtilis
BGC0000310.5 |  | 0.38 | NRPS | bacitracin | Bacillus licheniformis
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0002575.2 |  | 0.37 | ribosomal | cochonodin I | Streptococcus suis
BGC0000188.5 |  | 0.37 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001727.3 |  | 0.36 | ribosomal | paenilan | Paenibacillus polymyxa E681

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.08 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CFVJ01000010.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 37,093 - 47,392 nt. (total: 10,300 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: back translocase
AP598_RS05315: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase
AP598_RS05310: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.39 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002382.3 |  | 0.39 | ribosomal | grimoviridin | Grimontia marina
BGC0001525.3 |  | 0.37 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155
BGC0001526.4 |  | 0.36 | other (other) | bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K | Synechocystis salina LEGE 06099
BGC0000538.3 |  | 0.36 | ribosomal | nisin Z | Lactococcus lactis
BGC0002322.3 |  | 0.36 | ribosomal | citrocin | Citrobacter pasteurii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000504.5 |  | 0.40 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.39 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002382.3 |  | 0.39 | ribosomal | grimoviridin | Grimontia marina
BGC0001525.3 |  | 0.37 | other (other) | bartoloside B, bartoloside C, bartoloside D | Synechocystis salina LEGE 06155
BGC0001526.4 |  | 0.36 | other (other) | bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K | Synechocystis salina LEGE 06099
BGC0000538.3 |  | 0.36 | ribosomal | nisin Z | Lactococcus lactis
BGC0002322.3 |  | 0.36 | ribosomal | citrocin | Citrobacter pasteurii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
Additional weak hits (2):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.66 out of 20.47
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MogR | Repressor of flagellar motility genes

NZ_CFVJ01000015.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,478 - 22,414 nt. (total: 17,937 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
AP598_RS06665: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002577.2 |  | 0.56 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000624.3 |  | 0.55 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002579.2 |  | 0.54 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0000619.3 |  | 0.50 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.50 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.50 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.46 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002577.2 |  | 0.56 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000624.3 |  | 0.55 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002579.2 |  | 0.54 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0000619.3 |  | 0.50 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.50 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.50 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.46 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.43 out of 24.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06
Confidence: medium
Additional weak hits (4):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.72 out of 19.52
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CFVJ01000022.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 21,757 nt. (total: 21,757 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
AP598_RS08145: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: phosphotransferase
AP598_RS08165: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Ligases: synthase
AP598_RS08140: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000592.5 |  | 0.40 | ribosomal | microviridin B | Microcystis aeruginosa NIES-298
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001743.3 |  | 0.39 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001928.2 |  | 0.39 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000592.5 |  | 0.40 | ribosomal | microviridin B | Microcystis aeruginosa NIES-298
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001743.3 |  | 0.39 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001928.2 |  | 0.39 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.14 out of 20.97
Confidence: strong
Additional weak hits (2):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.53 out of 27.18
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator

NZ_CFVJ01000025.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 19,905 - 26,695 nt. (total: 6,791 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.50 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002005.2 |  | 0.47 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001862.4 |  | 0.45 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000624.3 |  | 0.42 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002698.2 |  | 0.41 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000617.5 |  | 0.40 | ribosomal | coagulin | Bacillus coagulans
BGC0000517.4 |  | 0.40 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.50 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0002005.2 |  | 0.47 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001862.4 |  | 0.45 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000624.3 |  | 0.42 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002698.2 |  | 0.41 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000617.5 |  | 0.40 | ribosomal | coagulin | Bacillus coagulans
BGC0000517.4 |  | 0.40 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.78 out of 30.98
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CFVJ01000033.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,543 nt. (total: 16,543 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: back translocase
AP598_RS09440: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthetase
AP598_RS09465: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001594.3 |  | 0.27 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0001595.3 |  | 0.27 | other (other) | fischerindole | Fischerella sp. SAG 46.79
BGC0000668.5 |  | 0.27 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001594.3 |  | 0.27 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0001595.3 |  | 0.27 | other (other) | fischerindole | Fischerella sp. SAG 46.79
BGC0000668.5 |  | 0.27 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
AP598_RS09465: PT_FPPS_like
Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.22 out of 18.16
Confidence: strong
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria