LOCUS       NZ_CP011522            10870 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces sp. CFMR 7 strain CFMR-7 chromosome, complete genome.
ACCESSION   NZ_CP011522
VERSION     NZ_CP011522.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CFMR 7
  ORGANISM  Streptomyces sp. CFMR 7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Complete genome sequence of Streptomyces sp strain CFMR 7, a natural
            rubber degrading Actinomycetes isolated from Penang, Malaysia
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) School of Biological Sciences, University
            Science Malaysia, Minden, Gelugor, Georgetown, Penang 11800,
            Malaysia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 147x
            Sequencing Technology             :: PacBio RS
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001278095.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 02:27:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,124
            CDSs (total)                      :: 7,038
            Genes (coding)                    :: 6,918
            CDSs (with protein)               :: 6,918
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 35 of 120
            Pseudo Genes (incomplete)         :: 96 of 120
            Pseudo Genes (internal stop)      :: 7 of 120
            Pseudo Genes (multiple problems)  :: 16 of 120
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8140904
            Orig. end                         :: 8151774
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011522.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="38"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10870
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5870](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(265..1668)
                     /locus_tag="ABE83_RS34175"
                     /old_locus_tag="ABE83_34240"
     CDS             complement(265..1668)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515152.1"
                     /locus_tag="ABE83_RS34175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34240"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_053562524.1"
                     /transl_table=11
                     /translation="MIRTGGSGPARRPSGNPARDRLRRLQLRLTAAYTLITLAGVSCLA
                     WLVIRTDDRSREAAEYDEMRRRASVAASLVYYEDDRIRLDGLADDEATAGTPQILVLEG
                     RPGGGAAVVFRGGVQQFDVPATALARAAGAAMRGEETVREEARDRTGGPVRLLAVPFWH
                     DATDEVAGAAVAVGDPAYGAAEHRSLVLSLVVGCAALTALAALTGHVLSGRSLRPAWQA
                     LEQQERLLADAAHELRTPVAVMRGSVELAERGSGGADAYLPGIRRAADRMGHVVENLLT
                     RGRLEAAVETVRAEPLRLDQLVEEVCAELPEGGHRLELRAAESVVEADAALVRVAVRNL
                     LDNAVRHGRTGGEPGMALGRAERHAAEPGEPGRADLLVTVDGPEVSVADRGPGVEPGRL
                     PELIERFRSPGGGTGIGLSLVHRVALAHRGALTVRARPGGGAVFVLRLAPPRSRRRAGA
                     ERVNRPTGD"
     gene            complement(1665..2327)
                     /locus_tag="ABE83_RS34180"
                     /old_locus_tag="ABE83_34245"
     CDS             complement(1665..2327)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236454.1"
                     /locus_tag="ABE83_RS34180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34245"
                     /product="response regulator transcription factor"
                     /protein_id="WP_029394871.1"
                     /transl_table=11
                     /translation="MRVLLVEDDDDLRAVIAAGLREAGFAVDGADDWPEADVMLHVTAY
                     DCVVLDRMLPSGDSLARLEERRRAGWPVPVLCLTALDALDERLHGLESGADDYLAKPFA
                     MRELVLRVRSLTRRAAERLPTFLSCADVVMDLARREVRRGGVLLSLSPKEYAVLQQLLV
                     HRGSVVTRTALLEHCWDEMADPVSNVVDAVIAGVRRKLGSPSLVRTVRGQGFLMGAR"
     gene            complement(2412..3419)
                     /locus_tag="ABE83_RS34185"
                     /old_locus_tag="ABE83_34250"
     CDS             complement(2412..3419)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491079.1"
                     /locus_tag="ABE83_RS34185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34250"
                     /product="LysR family transcriptional regulator ArgP"
                     /protein_id="WP_239009283.1"
                     /transl_table=11
                     /translation="MMSELPLDQVRTLLAVVDEGTFDAAASALRVTPSAVSQRVKALER
                     RTGRVLLMRTKPVRPTESGEVVVRFARQLARLEQDAQSALGMSGPGEPTRLSIAVNSDS
                     LATWFLPALGRVPEELGICYELRREDQDHTAALLREGLVMAAVTSSPEAVSGCSVRSLG
                     RMRYLPVATAAFAERWLGRGTATPLRELIVDAPVVDFDRRDDIQASFTRALGCGRRAAR
                     RRHFVPTSEGFVDAVAAGMGWGMLPDVHARPLLDSGRLVVLTPDRHVDVPLYWQQWKLD
                     SPALATVAGAVAAEAAEALGGGAGAGRIGGGPPEARAGRTGSGRPGTRAGRATP"
     misc_feature    3428..3441
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.92"
                     /tool="antismash"
     misc_feature    complement(3428..3444)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(3429..3442)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.19"
                     /tool="antismash"
     misc_feature    3434..3449
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(3436..3449)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.41"
                     /tool="antismash"
     misc_feature    complement(3437..3452)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.09"
                     /tool="antismash"
     gene            3486..4097
                     /locus_tag="ABE83_RS34190"
                     /old_locus_tag="ABE83_34255"
     CDS             3486..4097
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459226.1"
                     /locus_tag="ABE83_RS34190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34255"
                     /product="LysE/ArgO family amino acid transporter"
                     /protein_id="WP_053562526.1"
                     /transl_table=11
                     /translation="MTNALTTAAAGFGTGLSLIVAIGAQNALVLRQGVRREAVLAVVAI
                     CALSDAVLITLGVAGVGAVVVAWPSALAVVSLLGGVFLIGYGLLAARRAFRPSALLPQD
                     APSGATRGAVLACLAMTWLNPHVYLDTVFLLGSVAADRGPLRWTFGLGAVLASVCWFTA
                     LGFGARLLSGVLSRPSSWRVLDGLVAAMMIGLGVRLALTA"
     gene            complement(4128..4766)
                     /locus_tag="ABE83_RS34195"
                     /old_locus_tag="ABE83_34260"
     CDS             complement(4128..4766)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606642.1"
                     /locus_tag="ABE83_RS34195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34260"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_053562527.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQAILMAAAETFEKHGYQAATITEILRIAGVTKGA
                     LYFHFPSKEELALGVLEAQEPPPPAPDQPLKLQELVDMGMMFSHRLHTSLLTRAGVRLS
                     MDQQAQGLDRTGPFLRWQQTTHGLLAHAKQNGELLPHVNPMETADLYVAAFTGIQAVSQ
                     TLTNYRDLEQRYITLQRHILPSIATPSILTALDLSPQRTSDLARLAPAY"
     misc_feature    4839..4859
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    complement(4901..4917)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     gene            5001..5870
                     /locus_tag="ABE83_RS34200"
                     /old_locus_tag="ABE83_34265"
     CDS             5001..5870
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761876.1"
                     /locus_tag="ABE83_RS34200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34265"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_093750710.1"
                     /sec_met_domain="AfsA (E-value: 2.3e-25, bitscore: 87.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELVHRSRAEDAFPRSWVRLGPDRFHVEAVLPHDHPFFAPVGADR
                     HDPLLVTEAMRQAAMLAFHAGYGVPVGHHFLMADLDYATHPEHLVVGGLPTVIDVEVTC
                     SELKWRAGLPVQGRVDWVVRRAGQLVATGMGATRFTSPRVYRRMRGGSAEPGVAIPRTV
                     PVDAARAGRDRVEDVVLSKGARAGVWELRVDTRHPTLFQRPNDHVPGMLLLEAARQAAC
                     LAAGDGRFVPAEGRTHFHRYAEFGTPCTIAADVLAGAAPGEARIRVTGRQDGEPVFDSV
                     LTGPSGTI"
     misc_feature    complement(5946..5961)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            5947..6807
                     /locus_tag="ABE83_RS34205"
                     /old_locus_tag="ABE83_34270"
     CDS             5947..6807
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491075.1"
                     /locus_tag="ABE83_RS34205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34270"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_053562529.1"
                     /transl_table=11
                     /translation="MILVTGATGAVGGEVARLLAAEGPVRILARRPERVTVHGPDVEVV
                     AGEYADREALDRALRGIDAVFLVTNSPKEPDDLRVATAARAAGVRHLVKLSMMAVEEPG
                     ADDFITRLQRGNEEAIRESGVPWTFVRPRTFMSNTLSWAKGIASDGVVRALYGDSPVAC
                     VDPRDVAAVAVAALTGTGHEGRAYAVSGPEPITAREQTAHLSEVLGRPLRFEQLPPDRA
                     REALLAKYPSPVAEAFLESAERQRAGAKAAVVPTVEELTGRPARTFRTWAADHAESFAA
                     ADLGV"
     gene            6985..7671
                     /locus_tag="ABE83_RS34210"
                     /old_locus_tag="ABE83_34275"
     CDS             6985..7671
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515159.1"
                     /locus_tag="ABE83_RS34210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34275"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_053562530.1"
                     /transl_table=11
                     /translation="MTKQVRAARTRQALIRSAAIVFEQHGYAQARLALISSGAGVSTGA
                     LHFHFENKAAVAQAVVAEASHGLLAVSSSIRRRTDTALQTLVDTSHALVDLLARDPVTR
                     AGFRLSCDGVRGDEPGLPAQWQRCVGELLDEAAAAGTLAEDVSRTDATAATVAATTGFE
                     VLGRYESEWLSAPTPTGFWRLLLPRLATPETLPLLDPSGTAAAAEAVATGPDGHRTSGV
                     GAAAPI"
     gene            complement(7690..8121)
                     /locus_tag="ABE83_RS34215"
                     /old_locus_tag="ABE83_34280"
     CDS             complement(7690..8121)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761874.1"
                     /locus_tag="ABE83_RS34215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34280"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_053562531.1"
                     /transl_table=11
                     /translation="MEDIKDPYELRVGVPSVELFRRLRTDAGLSDKAPEAVAIALPNTW
                     HGVVLHHEGEPIGMGRIIGDGGTAFQVVDVCVHPAHQGRGLGRRIMAALTEELERRAPA
                     TAYVSLIADGPARFLYEKFGFADTAAHDSIGMYRSMGPA"
     misc_feature    complement(8120..8133)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.66"
                     /tool="antismash"
     gene            complement(8170..9135)
                     /locus_tag="ABE83_RS34220"
                     /old_locus_tag="ABE83_34285"
     CDS             complement(8170..9135)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761873.1"
                     /locus_tag="ABE83_RS34220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34285"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_053562532.1"
                     /transl_table=11
                     /translation="MDDQPGTSAPEPLDRRAELSEFLRTRRARLRPQDVGLPEFGRARR
                     VPGLRREELAQLAGVSVAYYTRLEQGNGRNVSAEVLDAIARALRLSDAEHAHLTHLAKP
                     GQHKKKRRPARVQRVRTGLLYLLESLEGVPAYVSGARSDILAWNPMAAAVFGDWGALPP
                     EERNWARLVFLSPAYRDLFVEWDTKASDMVSYLRLYAGCHPDDPRLSALVGELSVKNDE
                     FRRLWATHNVKEKGHGVKLLRHPLVGDMALSYETLHLPDDPEQYLVTYHAEPGSASAQA
                     LRLLASWGADAGRADADRIDPVGGTDRAGPGGMAGRGEGG"
     misc_feature    complement(9211..9226)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            9288..10328
                     /locus_tag="ABE83_RS34225"
                     /old_locus_tag="ABE83_34290"
     CDS             9288..10328
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (19-269). E-value: 4.1e-13.
                     Score: 41.1. Matches aSDomain:
                     nrpspksdomains_ABE83_RS34225_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761872.1"
                     /locus_tag="ABE83_RS34225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34290"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_053562533.1"
                     /sec_met_domain="ADH_N (E-value: 7.4e-28, bitscore: 95.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.4e-21, bitscore:
                     74.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVAAYAAPRAKAPLERTTIERRPVGEFDVLIEIKFAGICHSDI
                     HQARDGWGEGIFPMVPGHEIAGIVTETGPGVTRFKAGDRVGVGCMVDSCGQCDACRMGR
                     EQHCVEGNTQTYNALDRSGEPTYGGYSTHIVVREGFVVSIPEGIALDEAAPLLCAGITT
                     YSPLRRWGAGPGKKVAVIGLGGLGHMAVKIAHTLGAEVTVLSQSLRKKDDGLKLGADHY
                     YATSDPKTFEELAGTFDIILSTVSAPLDFGAYLALLRTDGTLVNVGAPEEPISLNLFSL
                     IGGNKSLAGSAIGGIAETQEMLDFCAVHGLGAEIEVIAADQVNEAYERVLASDVRYRFV
                     IDTATI"
     aSDomain        9345..10094
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ABE83_RS34225_PKS_ER.1"
                     /evalue="4.10E-13"
                     /label="ABE83_RS34225_PKS_ER.1"
                     /locus_tag="ABE83_RS34225"
                     /protein_end="269"
                     /protein_start="19"
                     /score="41.1"
                     /tool="antismash"
                     /translation="TIERRPVGEFDVLIEIKFAGICHSDIHQARDGWGEGIFPMVPGHE
                     IAGIVTETGPGVTRFKAGDRVGVGCMVDSCGQCDACRMGREQHCVEGNTQTYNALDRSG
                     EPTYGGYSTHIVVREGFVVSIPEGIALDEAAPLLCAGITTYSPLRRWGAGPGKKVAVIG
                     LGGLGHMAVKIAHTLGAEVTVLSQSLRKKDDGLKLGADHYYATSDPKTFEELAGTFDII
                     LSTVSAPLDFGAYLALLRTDGTLVNVGA"
     CDS_motif       9471..9506
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ABE83_RS34225_0001"
                     /evalue="1.10E-02"
                     /label="PKSI-ER_m2"
                     /locus_tag="ABE83_RS34225"
                     /protein_end="73"
                     /protein_start="61"
                     /score="8.9"
                     /tool="antismash"
                     /translation="GHEIAGIVTETG"
     gene            complement(10428..10781)
                     /locus_tag="ABE83_RS34230"
                     /old_locus_tag="ABE83_34295"
     CDS             complement(10428..10781)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761871.1"
                     /locus_tag="ABE83_RS34230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_34295"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_053562534.1"
                     /transl_table=11
                     /translation="MSPTGPAVTSGRPLAHPPVEEIGLEGVLRALADPVRLRIVRGLAD
                     GHPDMACVAFDLPVSKSTTTHHFKVLREAGVIHQRYEGTSRLSRLREADLEARFPGLLA
                     AVLEAARRTAPGA"
     misc_feature    10827..10843
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
ORIGIN
        1 cggggtgtag gcgccgccga tctggtagtc gaaggtggcg ttcgcctgcg ggaggacgac
       61 ctccggcgcg ggcttggccg cgaacgcgct ggagagcagg acccccgcgc cggccgccac
      121 ggcgaccccg ccggccaggg ccgcgagggt cgatctgcgg cggaggaagg gggtgacggc
      181 gtgcttggac atggggactc ccgggcgtgg tctgcgtacc tgctcccaca tcatgaacgg
      241 cggatcatga gcgaatcgtg agcgtcagtc tcccgtcggc ctgtttaccc gctccgcccc
      301 tgctctccgc cgcgaccggg gcggtgcgag ccgcagcacg aacaccgcac cgccaccggg
      361 ccgggcgcgg acggtcaggg cgccccggtg ggcgagggcc acccggtgca ccagcgagag
      421 cccgatgccc gtaccgccgc ccggcgaacg gaagcgctcg atcagctccg gcagccgccc
      481 cggctccacc cctggccccc ggtcggccac cgacacctcg ggcccgtcga cggtcacgag
      541 aagatcggcc cggccgggct ccccgggctc ggccgcgtgg cgttccgcgc ggccgagggc
      601 catgcccggc tccccgcccg tccggccatg gcgtacggcg ttgtcgagca agttgcgtac
      661 ggccacccgc accagcgccg cgtcggcctc gaccaccgac tccgccgccc gcagctccaa
      721 ccggtgcccg ccctccggca gttcggcgca gacctcctcc acgagctggt ccagccgcag
      781 cggctcggcc cgtaccgtct ccacggcggc ctccagccgc ccccgggtca gcaggttctc
      841 caccacatgg cccatccggt ccgccgcccg gcggatcccc ggcagatacg cgtccgcccc
      901 accggaaccg cgctcggcca gctccaccga accgcgcatc accgccaccg gcgtccgcag
      961 ctcgtgcgcc gcgtcggcga gcagccgctc ctgctgctcc agcgcctgcc aggcgggccg
     1021 caggctgcgc ccggagagca catggccggt gagcgcggcc agggcggtga gggccgcgca
     1081 cccgacgacc agcgagagga ccaggctgcg gtgctcggcc gccccgtacg ccgggtcccc
     1141 gaccgcgacg gccgcgcccg ccacctcgtc ggtcgcgtcg tgccagaagg gcacggccag
     1201 cagccggacc gggccgcccg tacggtcgcg agcctcctcc cgtacggtct cctccccgcg
     1261 catcgccgca cccgccgccc gggcgagtgc cgtggccggt acgtcgaact gctggacgcc
     1321 gccccggaac accacggcag caccgccccc gggccgtccc tccagcacca ggatctgggg
     1381 cgtgcccgcg gtcgcctcgt cgtcggccag gccgtcgagc cggatgcggt cgtcctcgta
     1441 atagacgagc gaggccgcga cggaggcccg gcggcgcatc tcgtcgtact cggcggcctc
     1501 ccgcgaccgg tcgtcggtac ggatcaccag ccaggccagg cagctcaccc cggcgagggt
     1561 gatcagcgtg tacgcggcgg tcagccgcag ttggagccgg cgcagccggt cccgggcggg
     1621 gtttcctgat gggcgccgcg ccggtccgga gccgcccgtc cggatcaccg ggcgcccatc
     1681 aggaaaccct gcccgcgcac ggtccgtacg agggacgggg agcccagctt gcgccgcact
     1741 ccggcgatga cggcgtccac cacgttggag accgggtcgg ccatctcgtc ccagcagtgc
     1801 tccagcagcg ccgtacgcgt gacgacgctg ccccggtgga ccaggagctg ctggagcacg
     1861 gcgtactcct tcgggctcag cgagagcagc accccgccgc gccgcacctc gcgccgggcc
     1921 aggtccatca ccacgtcggc gcagctcagg aaggtgggca gccgctcggc cgcccgccgg
     1981 gtgagactcc gtacgcgcag gacgagttca cgcatcgcga agggcttggc gaggtagtcg
     2041 tccgccccgc tctccagccc gtgcagccgc tcgtccaggg cgtccagggc ggtgaggcag
     2101 agcacgggca ccggccagcc cgcccggcgc cgctcctcca gccgtgcgag ggagtcgccg
     2161 gagggcagca tccggtccag gaccacacag tcgtacgcgg tgacatggag catcacgtcc
     2221 gcctccggcc agtcgtccgc accgtccacg gcgaaccccg cctcgcgcag cccggcggcg
     2281 atcaccgccc gcaggtcgtc gtcgtcctcc accagcagca cgcgcaagga gacgcctccg
     2341 ggtcgctcgg ggccggcccc ggacgcctcc gtaccggcac cgggagcctg acctggggaa
     2401 gacccgccat cctaaggcgt ggcccgcccc gcccgcgttc ccggtcggcc gctgcccgtc
     2461 cgccccgccc gcgcttccgg tgggccgccg ccgatccggc cggcgcccgc gcccccgccg
     2521 agcgcctccg cggcctccgc cgccacggcc ccggccacgg tcgccagggc gggcgagtcc
     2581 agcttccact gctgccagta cagggggacg tcgacgtgcc ggtccggggt gaggacgacc
     2641 agccggccgg agtccagcag cgggcgggcg tggacgtcgg gcagcatgcc ccagcccatc
     2701 cccgccgcca cggcgtccac gaacccctcc gacgtgggga cgaagtggcg ccgccgggcg
     2761 gcccgccgcc cgcacccgag ggcgcgggtg aaggaggcct ggatgtcgtc gcgccggtcg
     2821 aagtccacca ccggcgcgtc cacgatcagc tcgcgcagcg gggtcgccgt cccccgcccc
     2881 agccaccgct ccgcgaaggc cgccgtcgcc accggcagat agcgcatcct gcccagactc
     2941 cgcaccgaac acccgctcac cgcctccggg gacgaggtca ccgccgccat caccagcccc
     3001 tcgcggagca gcgcggcggt gtggtcctgg tcctcccggc gcagctcgta acagatgccc
     3061 agttcctccg gcacccggcc tagggcgggg aggaaccagg tggccagcga atcggagttg
     3121 accgcgatcg acagccgggt cggctcgccg gggccggaca tgccgagggc cgactgcgcg
     3181 tcctgctcca gccgggcgag ctggcgggcg aagcgcacca cgacctcgcc ggactcggtg
     3241 ggccgcaccg gcttcgtccg catcagcagc acccggccgg tgcgccgctc cagggccttc
     3301 acccgctggc tgaccgccga gggcgtcacc cgcagggcgc tcgccgcggc gtcgaaggtg
     3361 ccttcgtcga cgacggccag gagggtccgc acctgatcga gggggagttc cgacatcacg
     3421 acagctaatg ttacttaaga atcattagct gtacacggat gtcggggctc cctaacgtct
     3481 ggtccatgac caacgctctg accaccgcgg ccgccgggtt cggtaccggc ctctccctca
     3541 tcgtcgccat cggcgcccag aacgccctgg tcctgcgcca gggcgtccgc cgggaggccg
     3601 ttctcgcggt ggtcgccatc tgcgcgctct ccgacgcggt cctcatcacc ctcggcgtcg
     3661 ccggggtcgg ggccgtggtc gtggcctggc cctccgccct ggccgtggtc tccctgctgg
     3721 gcggggtgtt cctgatcggt tacggcctcc tggccgcgcg ccgggccttc cgcccctccg
     3781 ccctcctgcc gcaggacgcg ccctccgggg cgacgcgggg tgccgtgctc gcctgcctcg
     3841 cgatgacctg gctcaacccg cacgtctacc tggacaccgt gttcctgctg ggctccgtcg
     3901 ccgccgaccg cggcccgctg cgctggacct tcgggctggg cgcggtcctc gccagcgtgt
     3961 gctggttcac tgctctcggc ttcggcgccc ggctgctgag cggggtgctg tcccgcccgt
     4021 cgtcgtggcg ggtgctggac gggctggtcg ccgccatgat gatcggcctc ggcgtccgac
     4081 tggccctgac cgcctgaccg cccgaccgcc gcgcggtcgc gtggccgtca gtacgcgggt
     4141 gcgagccggg cgaggtcgct ggtgcgctgg gggctgaggt cgagggcggt aaggatggag
     4201 ggtgtggcga tactggggag gatgtgccgc tggagtgtga tgtaacgctg ttccagatcg
     4261 cggtagttgg tgagggtctg ggagaccgcc tggatgccgg tgaaggccgc gacatagagg
     4321 tcggcggtct ccatggggtt gacgtgcggg aggagttcgc cgttctgttt ggcgtgggcc
     4381 aggaggccgt gggtggtctg ctgccagcgg aggaacggac cggtccggtc cagcccctgg
     4441 gcctgctggt ccatcgagag ccggacgccg gcgcgggtga ggaggctggt gtggaggcgg
     4501 tggctgaaca tcatccccat gtccaccagt tcctggagtt tgaggggctg atcgggggcg
     4561 ggcggcgggg gttcctgtgc ctccagcacc ccgagcgcga gttcctcctt ggacgggaaa
     4621 tggaaataga gcgcgccttt cgtcaccccg gcgattctga gtatttccgt gatggtggcg
     4681 gcctggtatc cgtgtttctc gaaggtctcc gccgctgcca tcaggatcgc ctgacgggtg
     4741 cggatagccc ggtcctgctt ggccatccct gtctccttcg tggggctgtg ccggacgtgg
     4801 gccgggcggg cggtttgtgg gggtcctggg gatagaaaaa aaaccgctta gtctgtatct
     4861 tatcagcgcg tgtgcaccgc aggaacggct cgcccatcac ataacccctg gggggagtta
     4921 tgcccgaagc agcagtgttg accgatcctg taacggcgtc agccgtgggt ccggaagccc
     4981 gaacggcgca tccggtgccc atggagctgg tccacaggag cagggcggag gacgcgttcc
     5041 cgcgcagctg ggtgcggttg ggcccggacc ggttccacgt cgaggcggtg ctgccgcacg
     5101 atcacccctt cttcgccccg gtcggggcgg accgccatga cccgctgctg gtgacggagg
     5161 cgatgcggca ggccgcgatg ctggccttcc acgccgggta cggagtcccc gtcggccacc
     5221 acttcctgat ggcggatctg gactacgcga cccaccccga gcacctggtc gtgggcggcc
     5281 tgcccaccgt gatcgacgtg gaggtgacct gctccgagct gaagtggcgt gccgggctgc
     5341 cggtgcaggg ccgcgtcgac tgggtggtcc gccgcgccgg gcagttggtc gcgacgggga
     5401 tgggcgcgac caggttcacc agcccgcggg tctaccggcg gatgcgcggc ggatcggcgg
     5461 agccgggcgt ggcgataccg cgcacggtgc cggtcgacgc cgcccgggcg ggccgcgacc
     5521 gggtcgagga cgtggtgctc tcgaagggcg cgcgcgcagg ggtctgggag ctgcgggtgg
     5581 acacccgcca cccgacgctc ttccagcgcc ccaacgacca tgtgccgggc atgctgttgc
     5641 tggaggcggc ccgtcaggcg gcgtgcctgg ccgccgggga cggcaggttc gtccccgccg
     5701 aggggcgtac gcacttccac cggtacgcgg agttcggcac cccgtgcacc atcgccgcgg
     5761 acgtcctggc gggcgccgca ccgggcgagg ccaggatccg ggtgaccggc cgtcaggacg
     5821 gcgagcccgt cttcgattcg gtgctgacgg gcccgtccgg cacgatctga agcacgcgtt
     5881 cgggcggcgc ggtcgcgacg ggcggcccgg cggcggtccg atgacggttc atgaggagta
     5941 cgtgacgtga ttctggtgac aggggcgacc ggggcggtcg gcggtgaggt cgcacgactg
     6001 ctggcggccg agggcccggt gcggatcctg gcgaggcggc cggaacgcgt gacggtgcac
     6061 ggccccgacg tggaggtcgt ggcgggggag tacgcggatc gcgaggcgct cgaccgggcg
     6121 ctgcggggga tcgacgcggt cttcctggtg accaacagcc cgaaggaacc ggacgacttg
     6181 agggtcgcga cggccgcgcg ggcggcgggc gtacgccacc tggtgaagct gtcgatgatg
     6241 gcggtggagg agcccggcgc ggacgacttc atcacccgtc tccagcgggg caacgaagag
     6301 gccatacggg aatcgggggt tccctggacg ttcgtacgcc ccaggacctt catgtccaac
     6361 acgctctcct gggcgaaggg catcgcgtcg gacggcgtgg tgcgggccct gtacggcgat
     6421 tcgccggtcg cgtgtgtcga cccgcgggac gtcgcggcgg tggcggtcgc cgccctcacc
     6481 ggcacgggcc acgaggggcg ggcgtacgcg gtctcgggac cggagcccat caccgcgcgc
     6541 gagcagacgg cccacctctc cgaggtgctc ggccggccgc tgcgcttcga gcaactgccc
     6601 ccggaccggg cgcgcgaggc cctcctcgcg aagtatccga gccccgtggc cgaggccttc
     6661 ctggagagcg ccgagcgcca gcgcgccgga gccaaggcgg ccgtggtgcc caccgtcgag
     6721 gagctgacgg gccgccccgc caggactttc cgtacctggg cggcggatca cgcggagtcc
     6781 ttcgccgccg ccgacctggg cgtctagcgg aacgcgcgcc cacacggtgg ccgaccgcgc
     6841 acacgttccc ctggaaatca aaccggtaag ttggtttgat attcccatga cgctgcttgc
     6901 ccgctccggc ggagagtgcc cggcccccgc ggcccctggc ccaggccccc ttcccatccg
     6961 cttctccccc cggcggaggc tccggtgacc aagcaggtgc gcgccgcgcg tacccgccag
     7021 gccctgatcc gctccgccgc gatcgtgttt gagcagcacg ggtacgcgca ggcgcgcctg
     7081 gcgctgatca gttccggcgc gggggtcagc acgggtgcgc tgcacttcca cttcgagaac
     7141 aaggcggcgg tcgcccaggc cgtggtcgcg gaggcctcgc acggcctgct ggcggtgtcc
     7201 agttccatcc gccgccggac ggacacggcc ctgcagaccc tggtcgacac ctcccacgcc
     7261 ctggtcgacc tcctcgcccg cgacccggtg acccgggccg gcttccggct cagctgcgac
     7321 ggggtgcgcg gcgacgagcc gggcctgccc gcccaatggc agcgctgcgt gggggagttg
     7381 ctggacgagg cggccgccgc cggcaccctc gccgaggacg tctcccgtac ggacgccacg
     7441 gccgcgacgg tggcggcgac caccgggttc gaggtgctcg gacggtacga atccgagtgg
     7501 ctctccgccc ctacccccac cggcttctgg cggctgctgc tgccccgcct cgccaccccg
     7561 gagaccctgc ccctcctgga cccgtcgggc accgccgcgg cggcggaggc cgtcgccacg
     7621 ggcccggacg gccaccggac gtccggggtg ggggccgccg cccccatctg acctgccggt
     7681 gcgggaggtt caggccgggc ccatcgagcg gtacatgccg atggagtcgt gcgcggcggt
     7741 gtcggcgaag ccgaacttct cgtacaggaa gcgtgcgggc ccgtccgcga tcagcgagac
     7801 gtacgcggtg gcgggcgccc ggcgctccag ctcctcggtg agcgcggcca tgatgcgcct
     7861 gccgaggccc cggccctggt gcgcggggtg cacacagacg tcgaccacct ggaacgcggt
     7921 gccgccgtca ccgatgatcc gccccatgcc gatcggctcg ccctcgtggt ggaggaccac
     7981 gccgtgccag gtgttgggca gggcgatcgc caccgcctcg ggggccttgt cggagagccc
     8041 ggcgtcggtg cgcagtcggc ggaagagttc gacggagggc acgcccaccc ggagttcgta
     8101 agggtccttg atgtcttcca tgtattacac aataggggtc ccgcaacggt agggacgccc
     8161 ctggccgcgc tagccgccct cgccccggcc cgccatgccg ccgggaccgg cccggtccgt
     8221 cccgccgacc ggatcgatcc ggtccgcatc cgcccgtccc gcgtccgcgc cccagctcgc
     8281 cagcaggcgc agcgcctggg ccgacgcgga gcccggctcc gcgtggtagg tgaccaaata
     8341 ctgttccggg tcgtccggca gatgcagggt ctcgtaggac agggccatgt ccccgacgag
     8401 cggatgccgc aggagcttga cgccgtggcc cttctccttg acgttgtgcg tggcccacag
     8461 ccgcctgaac tcgtcgttct tgacggagag ttcacccacc agcgcggaga gccgcggatc
     8521 gtccgggtga catcccgcgt acaggcgcag atagctgacc atgtccgagg ccttggtgtc
     8581 ccattccacg aacaggtccc ggtaggcggg ggagaggaag acgagccgcg cccagttgcg
     8641 ctcctcgggc ggcagcgcgc cccagtcacc gaacaccgcc gccgccatcg ggttccaggc
     8701 caggatgtcg gagcgcgccc cgctgacgta cgcgggaacg ccctccaggc tctccaggag
     8761 atacagcagc ccggtccgca cccgctgcac ccgggccggg cggcgcttct tcttgtgctg
     8821 cccgggcttg gccagatgcg tcagatgcgc gtgctcggcg tcgctgaggc gcagcgcccg
     8881 ggcgatcgcg tcgagcacct cggccgacac attgcgcccg ttcccctgtt ccagccgcgt
     8941 gtagtacgcc acggagaccc cggccagctg cgccagctcc tcccgccgca gccccggcac
     9001 ccggcgggcc cgcccgaact ccggcagccc cacgtcctgc ggccggagcc gggcacgccg
     9061 ggtgcgcagg aactcgctga gttcggcgcg ccggtcgagc ggctcggggg cggaggtgcc
     9121 gggctgatcg tccatggacc ccattattcc tggtcgtacg cacaggagcc tgtccctgcc
     9181 agtagtagga ccggcggacg taggcaaggc ggtgacctgg gtaaacgctg ccggtcccgt
     9241 gatgctggat gacgttccta ccgcatcacc agaggagaac ctccggcatg accaccgttg
     9301 ccgcctacgc cgctccccgt gccaaggccc cgctggagcg caccacgatc gagcgccgtc
     9361 cggtcggcga gttcgacgtc ctcatcgaga tcaagttcgc gggcatctgc cactccgaca
     9421 tccaccaggc ccgggacggc tggggcgagg gcatcttccc gatggtgccc ggccacgaga
     9481 tcgccgggat cgtcaccgag accggccccg gcgtcacccg cttcaaggcc ggcgaccgcg
     9541 tcggcgtcgg ctgcatggtc gactcctgcg gacagtgcga cgcctgccgg atgggccgcg
     9601 aacagcactg cgtcgagggg aacacccaga cgtacaacgc cctcgaccgc agcggcgagc
     9661 cgacgtacgg gggctactcg acgcacatcg tcgtccgtga gggcttcgtg gtctccatcc
     9721 ccgagggcat cgccctggac gaggccgcgc cgctgctctg cgcgggcatc accacgtact
     9781 ccccgctccg ccgctggggc gccggtcccg gcaagaaggt cgccgtcatc ggcctcggcg
     9841 gtctcggcca catggccgtc aagatcgcgc acaccctcgg cgccgaggtc accgtcctct
     9901 cccagtccct gcgcaagaag gacgacgggc tcaagctggg cgccgaccac tactacgcga
     9961 ccagcgaccc gaagaccttc gaggagctgg ccggaacctt cgacatcatc ctctccacgg
    10021 tctccgcccc gctggacttc ggcgcctacc tcgccctcct gcggaccgac ggcaccctcg
    10081 tcaacgtggg cgcgcccgag gagccgatct cgctgaacct cttctcgctg atcggcggca
    10141 acaagtcgct ggcgggctcg gcgatcggcg gcatcgcgga gacgcaggag atgctcgact
    10201 tctgcgccgt gcacggcctc ggcgccgaga tcgaggtcat cgcggcggac caggtcaacg
    10261 aggcgtacga gcgcgttctc gccagtgacg tccgctaccg cttcgtgatc gacacggcga
    10321 cgatctgagc ggtccgacgg ccgtacgcgg gtgtgctgcg ccgggcactc gcgtacggac
    10381 gcgggtgtgc cccgggcccg gtgagggccc ggggcacacc catgcgctca ggcgccgggg
    10441 gcggtccgcc gtgccgcctc caggacggcc gccagcagcc cggggaaacg tgcctccagg
    10501 tcggcctcgc gcagtcggct caggcgtgag gtcccctcgt agcgctggtg gatgacgccc
    10561 gcctcgcgca gcaccttgaa gtggtgggtg gtggtcgact tgctcaccgg gaggtcgaag
    10621 gcgacgcacg ccatgtccgg gtgcccgtcc gccagccccc gcacgatccg cagccggacg
    10681 ggatcggcca gcgcccgcag gacaccctcc agaccgatct cttccacggg cggatgggcg
    10741 agcgggcgcc cggacgtgac cgcgggtccg gtgggggaca tggagcctcc tcaaggtccg
    10801 acggaccgct gaaagtacga caatcaccgt agtttgacaa ctaccgtact acgaggattt
    10861 cgtacggggc
//
