LOCUS       NZ_CP011522            10399 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces sp. CFMR 7 strain CFMR-7 chromosome, complete genome.
ACCESSION   NZ_CP011522
VERSION     NZ_CP011522.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CFMR 7
  ORGANISM  Streptomyces sp. CFMR 7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Complete genome sequence of Streptomyces sp strain CFMR 7, a natural
            rubber degrading Actinomycetes isolated from Penang, Malaysia
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) School of Biological Sciences, University
            Science Malaysia, Minden, Gelugor, Georgetown, Penang 11800,
            Malaysia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 147x
            Sequencing Technology             :: PacBio RS
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001278095.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 02:27:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,124
            CDSs (total)                      :: 7,038
            Genes (coding)                    :: 6,918
            CDSs (with protein)               :: 6,918
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 35 of 120
            Pseudo Genes (incomplete)         :: 96 of 120
            Pseudo Genes (internal stop)      :: 7 of 120
            Pseudo Genes (multiple problems)  :: 16 of 120
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6815094
            Orig. end                         :: 6825493
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011522.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="32"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5399)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            109..1191
                     /locus_tag="ABE83_RS28565"
                     /old_locus_tag="ABE83_28625"
     CDS             109..1191
                     /NRPS_PKS="Domain: Aminotran_5 (19-347). E-value: 2.1e-22.
                     Score: 71.5. Matches aSDomain:
                     nrpspksdomains_ABE83_RS28565_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488160.1"
                     /locus_tag="ABE83_RS28565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28625"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_053561734.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-15, bitscore:
                     55.5, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 0.00012, bitscore:
                     20.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISPLSRAAAAEFAPEVTYLNTSSWGLLPRRTIAAVKALADENA
                     AGRRIGAGSFEAVEAARVGFARLAGVRPDRVATGSSVTVHVGLIAASLPPGAEVLAPEG
                     EFTSVVSPFALRGDLRMRYVPLAELADAVRPTTALVAFSSVQSADGRVADLAAVRAAAA
                     AHGARTLLDATQSAGWFPLEAGAYDYTVAGGFKFLLCPRGTSFLTVTEEAQETLPKLFA
                     GWVAAGAPWTSNYGPLEHLAPGARGFDEPPAFLSYHGAEHSLALLGEIGTDALYAHATS
                     LAARLRAGLVERGYEVVPGESAIVSVPGLEGRQPELAEAGIAVSAPAGNLRISCHLYNT
                     GADVDRVLEVLGHREPRPSA"
     aSDomain        166..1149
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ABE83_RS28565_Aminotran_5.1"
                     /evalue="2.10E-22"
                     /label="ABE83_RS28565_Aminotran_5.1"
                     /locus_tag="ABE83_RS28565"
                     /protein_end="347"
                     /protein_start="19"
                     /score="71.5"
                     /tool="antismash"
                     /translation="YLNTSSWGLLPRRTIAAVKALADENAAGRRIGAGSFEAVEAARVG
                     FARLAGVRPDRVATGSSVTVHVGLIAASLPPGAEVLAPEGEFTSVVSPFALRGDLRMRY
                     VPLAELADAVRPTTALVAFSSVQSADGRVADLAAVRAAAAAHGARTLLDATQSAGWFPL
                     EAGAYDYTVAGGFKFLLCPRGTSFLTVTEEAQETLPKLFAGWVAAGAPWTSNYGPLEHL
                     APGARGFDEPPAFLSYHGAEHSLALLGEIGTDALYAHATSLAARLRAGLVERGYEVVPG
                     ESAIVSVPGLEGRQPELAEAGIAVSAPAGNLRISCHLYNTGADVDRV"
     gene            complement(1204..1716)
                     /locus_tag="ABE83_RS28570"
                     /old_locus_tag="ABE83_28630"
     CDS             complement(1204..1716)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957688.1"
                     /locus_tag="ABE83_RS28570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28630"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_019765415.1"
                     /transl_table=11
                     /translation="MNTGHADTAEAACTDALPGAALSGPVSHAVSRVARLHRIAAGKLL
                     KGLGLYPGQELLMMHLWDAGPVRQSELIRTLDLDPSTVTKMLQRLEQTGHVRRRPDPDD
                     RRAVLVEATEASCALHRAVRDAWGSLEEHTLAGLDDGERTELTRLLAKVEANLCRETEG
                     CPERQAL"
     gene            1921..2991
                     /locus_tag="ABE83_RS28575"
                     /old_locus_tag="ABE83_28635"
     CDS             1921..2991
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="ABE83_RS28575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28635"
                     /product="alkene reductase"
                     /protein_id="WP_053561735.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLAGTPLANRIVMAPMTRSRAGEGGTATELTAAYYAQ
                     RASAGLIVTEGIQPSAVGQGYPFTPGLHSAEQVASWRKVTDAVHAEGGRIFAQIMHAGR
                     IGHPVLLPDGLVPVAPSPVRAAGQVFTAEGPKDFVEPHELTDEEIRQTIADFVSASRNA
                     IEAGFDGVELHGANGYLIHQFLAPNTNLRTDAWGGSDERRVRFAAEVVKAVAAEIGGAR
                     TALRISPSNPYNDIDEPAPDAVYTALAQEIEPLGLAYLHILEDAPIRELTLQLRKVFTG
                     PVLINVHSDGPTGPDDHTVIDDGIADLISYGVLFLANPDLPARLKAGGPFNTPDPSTFF
                     GGDAKGYTDYPALDAV"
     gene            complement(2967..3998)
                     /locus_tag="ABE83_RS28580"
                     /old_locus_tag="ABE83_28640"
     CDS             complement(2967..3998)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070337.1"
                     /locus_tag="ABE83_RS28580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28640"
                     /product="VOC family protein"
                     /protein_id="WP_053561736.1"
                     /transl_table=11
                     /translation="MTSHVRHITIDCADPYALGTFWSRVLGAPLASDDFPGDPEALLET
                     PGAAILFVRNDDPKTVKNRVHLDIQPQDRTRDEEVERLLALGATLVGDHRRPDGRGWAT
                     PTDLEGNEFCVECSAAERAAPTGSRLPVTADDVTTAVRLAVDALAGATEGWDAPAGTLE
                     WTCWETVEHLSDDLFAYAVQLGPRTPPLDGEVPYRWAPERQGGPYNAVCADRAAGPAGL
                     LATLEASGALLASMARTTPPEVRSYHGFGISDPEGFAAMGVVETLVHTHDVAEGLGLDW
                     APPAALCDRALARLFPDAPAGGDRWTVLLWATGRAELPDHPRRTKWRWDGRPPADQTAS
                     SAG"
     gene            complement(4102..4995)
                     /gene="thpD"
                     /locus_tag="ABE83_RS28585"
                     /old_locus_tag="ABE83_28645"
     CDS             complement(4102..4995)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="ABE83_RS28585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28645"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_053561737.1"
                     /sec_met_domain="PhyH (E-value: 1.9e-37, bitscore: 128.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIAAKDLQSY
                     EYDGFLTVDQLITPDEVAVYRAELDRLIADPLIRADERSIVEKQSQNVRSVFEVHRISE
                     VFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENFDTNGGLMIMPGSHKTFLGCAGETPKDNYKKSLQMQDAGTPSDEALT
                     KMADRHGIRLFTGKAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENTAQEPFAAP
                     IRRPEFIGARDFTPVK"
     gene            complement(5001..5399)
                     /locus_tag="ABE83_RS28590"
                     /old_locus_tag="ABE83_28650"
     CDS             complement(5001..5399)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045195.1"
                     /locus_tag="ABE83_RS28590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28650"
                     /product="ectoine synthase"
                     /protein_id="WP_018488170.1"
                     /sec_met_domain="ectoine_synt (E-value: 8e-54, bitscore:
                     179.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIENTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNDETGETHWISPGTMYLLDGHERHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEA"
     gene            complement(5485..6747)
                     /gene="ectB"
                     /locus_tag="ABE83_RS28595"
                     /old_locus_tag="ABE83_28655"
     CDS             complement(5485..6747)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-363). E-value: 3.9e-72.
                     Score: 235.0. Matches aSDomain:
                     nrpspksdomains_ABE83_RS28595_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="ABE83_RS28595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28655"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_018488171.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.2e-77, bitscore:
                     258.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHSY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRALQELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALDAYWADGRVEQQTKERGLQVEQALL
                     AICAEEPTAQFRGRGLVWGMEFEDPARASAVCARAFELGLLLETSGPQSEVVKLLPPLT
                     ITTEELDEGLRTLARCVRETA"
     aSDomain        complement(5659..6663)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ABE83_RS28595_Aminotran_3.1"
                     /evalue="3.90E-72"
                     /label="ABE83_RS28595_Aminotran_3.1"
                     /locus_tag="ABE83_RS28595"
                     /protein_end="363"
                     /protein_start="28"
                     /score="235.0"
                     /tool="antismash"
                     /translation="FDRAQGARLTDEDGHSYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALQELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALDAYWADGRVEQQTKERGLQVEQALLAICAEEPTAQFRGRGLVWGMEFE"
     gene            complement(7064..7594)
                     /gene="ectA"
                     /locus_tag="ABE83_RS28600"
                     /old_locus_tag="ABE83_28660"
     CDS             complement(7064..7594)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121394.1"
                     /locus_tag="ABE83_RS28600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28660"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_078949852.1"
                     /transl_table=11
                     /translation="MTAAPADFARARSEFLSIDTPRVEDGAAIWRIARDSEVLDLNSSY
                     SYLLWCRDFAATSAVARGEDGEPIAFVTGYIRPDRPETLVVWQVAVDGAHRGKGLAATL
                     LDALTARVAADQGLSWIETTITPDNTASDRLFTSYAQRHDVALEREVLFDGGMFPEGTH
                     LPEVLYRIGPFTG"
     misc_feature    7605..7619
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     misc_feature    complement(7619..7631)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    7716..7730
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.76"
                     /tool="antismash"
     misc_feature    complement(7750..7765)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7760..7775
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(7760..7777)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    7781..7794
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    7894..7908
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            complement(7911..9017)
                     /locus_tag="ABE83_RS28605"
                     /old_locus_tag="ABE83_28665"
     CDS             complement(7911..9017)
                     /NRPS_PKS="Domain: Aminotran_5 (52-284). E-value: 1.5e-28.
                     Score: 91.7. Matches aSDomain:
                     nrpspksdomains_ABE83_RS28605_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957694.1"
                     /locus_tag="ABE83_RS28605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28665"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_053561739.1"
                     /sec_met_domain="Aminotran_5 (E-value: 6e-22, bitscore:
                     76.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTADRFAAIERRVAALLATGQDVVITQGEALLPLE
                     GCIRSGARPGSTALNVVTGPYGQTFGNWLRDCGAQVVDLTVPFHTAVTADQVAEALAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSGRAWERFAANPAAPRRSYLSLLDWKERWIDAGRTALPHAP
                     AQLEMLGLDACLERIEADGLEKVMARHAAAAAATRAGAVALGGGLEPYVHEARDAAPVA
                     TTLRAPAGTDAAALVARALATDPSLPLVAGGGALSKEMIRVNHYGADATASAVLSSLAA
                     LGEALGATGRQVDFDAARRAVSETSPGL"
     aSDomain        complement(8166..8861)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ABE83_RS28605_Aminotran_5.1"
                     /evalue="1.50E-28"
                     /label="ABE83_RS28605_Aminotran_5.1"
                     /locus_tag="ABE83_RS28605"
                     /protein_end="284"
                     /protein_start="52"
                     /score="91.7"
                     /tool="antismash"
                     /translation="RPGSTALNVVTGPYGQTFGNWLRDCGAQVVDLTVPFHTAVTADQV
                     AEALAEHPEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDA
                     WGVDLCVIGAQKAMGGPAGVSAVSVSGRAWERFAANPAAPRRSYLSLLDWKERWIDAGR
                     TALPHAPAQLEMLGLDACLERIEADGLEKVMARHAAAAAATRAGAVALGGGLEPYVHEA
                     RDAAPVATTL"
     gene            9178..10290
                     /locus_tag="ABE83_RS28610"
                     /old_locus_tag="ABE83_28670"
     CDS             9178..10290
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607776.1"
                     /locus_tag="ABE83_RS28610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_28670"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_078949853.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.3e-19, bitscore:
                     67.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDQVRDQERQPVLRVKGRVLVGPDEVRDELWAVDGRITYERPPG
                     AEGAQTVTGWALPGLVDAHCHVGLDAHGPVDAATAEKQALTDRGAGTLLVRDAGSPSDT
                     RWIDDREDLPKIIRAGRHIARTRRYIRNYAHEIEPGDLVAYVAREARRGDGWVKLVGDW
                     IDRSAGDLTACWPRGEVEAAIAEAHRLGARVTAHCFAEESLRDLVEAGIDCIEHATGLT
                     EETVPLFAERGVAIVPTLVNIATFPDLAAGGEAKFPRWSAHMRRLYERRYDTVRAAYDA
                     GIPVYVGTDAGGSLAHGLVAGEVAELVKAGIPPLEALSATTWGARGWLGRPGLEEGAPA
                     DLVVYDEDPRADVRVLAAPRHVVLNGRVVG"
ORIGIN
        1 aaccctcgtc ccgcgtaggg gcgaccctcg cctccataag gaatccttgg ggccacgacg
       61 taaaattcgg tcattgacta tgaggtgcgg cggctccagg ctgagcccat gacgatctct
      121 ccgctcagcc gggccgccgc cgccgagttc gcgcccgagg tcacctacct caacacctca
      181 agctgggggc tgctgccccg ccggaccatc gccgccgtca aggccctcgc cgacgagaac
      241 gccgccggcc gccggatcgg tgcgggcagc ttcgaggcgg tggaggcggc ccgggtcggc
      301 ttcgcccggc tcgccggggt ccggccggac cgggtcgcca ccggcagctc ggtcaccgtc
      361 catgtcgggc tgatcgccgc ctcgctcccg cccggggccg aagtcctggc gcccgagggg
      421 gagttcacct ccgtcgtcag cccgttcgcg ctccggggcg atctgcggat gcggtacgtc
      481 cccctcgcgg agctggccga cgccgtacgc cccacgaccg cgctcgtcgc cttctcctcg
      541 gtccagtcgg ccgacggccg ggtcgccgat ctcgccgccg tccgcgcggc cgccgccgcc
      601 cacggggccc ggaccctgct ggacgccacg cagtcggcgg gctggttccc gctggaggcg
      661 ggggcgtacg actacaccgt cgcgggcggc ttcaagttcc tgctctgccc ccggggtacg
      721 tcgttcctga ccgtgaccga ggaggcgcag gagaccctgc cgaagctctt cgcgggctgg
      781 gtcgccgccg gggcgccctg gacgagcaac tacggtccgc tggagcatct cgcccccggg
      841 gcccgggggt tcgacgagcc gcccgccttc ctctcgtacc acggggccga gcactcgctc
      901 gcgctgctcg gggagatcgg caccgacgcg ctgtacgccc acgccacctc gctggccgcc
      961 cggctgaggg cggggctggt ggagcggggg tacgaggtgg tgccggggga gtccgcgatc
     1021 gtctccgtgc cggggctgga ggggcggcag ccggagctgg ccgaggccgg gatcgcggtc
     1081 tcggcgcccg ccgggaacct gcggatctcc tgccacctct acaacaccgg ggccgatgtg
     1141 gaccgggtgc tggaggtcct gggccaccgg gagccccggc cgagcgccta gagggcgtcc
     1201 ggcctagagg gcctgacgct ccgggcagcc ctccgtctcc cggcagaggt tcgcctccac
     1261 cttcgccagc agccgcgtca gctccgtacg ctcgccgtcg tccagcccgg cgagcgtgtg
     1321 ctcctccagg ctgccccacg cgtcccgtac cgcccggtgc agcgcgcagc tcgcctccgt
     1381 cgcctcgacc agcacggccc gccggtcgtc cgggtcgggg cggcggcgca catgaccggt
     1441 ctgctccagc cgctggagca tcttggtcac cgtggacggg tccaggtcca gcgtcctgat
     1501 cagctcggac tggcgtaccg gccccgcgtc ccacaggtgc atcatcaaca gctcctgccc
     1561 cgggtagagc cccagcccct tcagcagctt ccccgccgcg atccggtgca gccgggcgac
     1621 gcgggagacg gcgtggctca cgggcccgct gagcgctgct ccgggcagcg cgtcggtaca
     1681 ggcggcttcc gcggtgtcgg cgtgaccggt gttcatggcg tgctccttcg atacggctcc
     1741 ggcggggctt ccggtggttc ctggcgggtt cgggcggctt ccgggctcga tgacgcccac
     1801 ggcttgccca cactttacct tggtcggcca attaatgagc tacagtggcg ccagtgccaa
     1861 tacttggccg accacatact tcgttgatcg gtcaattacc tatctcttcc aggagtccgc
     1921 atgaccaccg ctttcgaccc gatcgacctg gccggcaccc ccttggccaa ccgcatcgtg
     1981 atggccccga tgacccgcag ccgggcgggc gagggcggta cggccaccga gctgaccgcc
     2041 gcctactacg cccagcgcgc ctccgccggg ctgatcgtca ccgagggcat ccagccctcc
     2101 gcggtcggcc agggctaccc cttcaccccc gggctgcaca gcgccgagca ggtcgcctcc
     2161 tggcgcaagg tcaccgacgc cgtgcacgcc gagggcggcc ggatcttcgc ccagatcatg
     2221 cacgcgggcc gcatcggcca cccggtcctg ctccccgacg gactcgtccc ggtcgccccc
     2281 tccccggtca gggccgcggg ccaggtcttc accgccgagg gccccaagga cttcgtcgag
     2341 ccgcacgagc tgaccgacga agagatccgg cagaccatcg cggacttcgt ctccgcctcc
     2401 cgcaacgcca tcgaggccgg gttcgacggg gtggagctgc acggcgccaa cggctatctg
     2461 atccaccagt tcctcgcgcc caacaccaac ctgcgcaccg acgcgtgggg cggctccgac
     2521 gagcgccgcg tccggttcgc cgcggaggtc gtcaaggcgg tcgcggccga gatcggcggg
     2581 gcccgtaccg ccctgcgcat ctcgccgtcc aacccgtaca acgacatcga cgagcccgcc
     2641 ccggacgccg tctacaccgc gctggcccag gagatcgagc cgctcggtct cgcctatctg
     2701 cacatcctgg aggatgcgcc gatccgcgag ctgaccctcc agctgcgcaa ggtgttcacc
     2761 ggccccgtcc tgatcaacgt gcactccgac gggccgaccg ggccggacga ccacaccgtg
     2821 atcgacgacg gcatcgccga cctcatctcg tacggcgttc tcttcctcgc caacccggac
     2881 ctgcccgccc gcctcaaggc cgggggcccc ttcaacaccc ccgacccgtc gaccttcttc
     2941 ggcggcgacg ccaagggcta caccgactac ccggcgctcg acgccgtctg atccgccggg
     3001 ggccgcccgt cccaccgcca cttcgtgcgg cgcgggtggt ccggcagttc cgcgcggccg
     3061 gtggcccaga gcagcacggt ccaccggtcg ccgcccgccg gggcgtcggg gaagagccgg
     3121 gccagcgccc ggtcgcagag ggcggcgggc ggcgcccagt ccagccccag cccctccgcg
     3181 acgtcatggg tgtgcaccag ggtctccacc acccccatcg cggcgaaccc ctccgggtcg
     3241 gagatcccga acccgtggta cgagcgcacc tccggcggcg tcgtccgcgc catcgaggcc
     3301 agcagcgcac cgctcgcctc cagggtggcc agcagcccgg cgggcccggc cgcccggtcc
     3361 gcgcagacgg cgttgtacgg cccgccctgc cgctcgggcg cccaccggta gggcacctca
     3421 ccgtcgagcg ggggcgtacg cgggcccaac tggacggcgt acgcgaagag atcgtcgctc
     3481 aggtgctcca ccgtctccca gcaggtccac tccagcgtcc ccgcgggcgc gtcccacccc
     3541 tccgtcgctc cggccagcgc gtccaccgcg agccgtacgg cggtcgtcac gtcgtcggcg
     3601 gtcaccggca gccgggaccc ggtcggcgcg gcccgctcgg ctgcggagca ctccacgcag
     3661 aactcgttcc cctccaggtc cgtgggggtg gcccaccccc gcccgtccgg tctgcggtgg
     3721 tcgcccacga gcgtggctcc gagcgcgagc agccgctcca cctcctcgtc ccgggtgcgg
     3781 tcctgcggct ggatgtccag gtggacccgg ttcttgacgg tcttcgggtc gtcgttccgg
     3841 acgaagagga tcgccgcgcc gggggtctcc agcagggcct ccgggtcgcc ggggaagtcg
     3901 tccgaggcca gcggcgcgcc gagcacccgg gaccagaagg tgccgagcgc gtaggggtcg
     3961 gcgcagtcga tcgtgatgtg ccgtacgtga gaagtcatgg ccgccacctt ctccggtggc
     4021 cggggcccgg tccaccgagt tacgcgcgag gggcccggaa cggcgtaccg ttccgggccc
     4081 ctcgcacagg ggtgtcttcc gctacttcac cggggtgaag tcccgcgccc cgatgaactc
     4141 cgggcggcgg atcggtgccg cgaacggctc ctgcgccgtg ttctccacgc tgttgaagac
     4201 gatgaagacg ttggaacggg cgtacggggt gatgttgtcg cccgaaccgt gcatggcgtt
     4261 gcagtcgaac caggtcgccg aaccggcctt gcccgtgaag agcctgatgc cgtgccggtc
     4321 ggccatcttc gtcagcgcct cgtcggacgg ggtgcccgcg tcctgcatct ggagcgactt
     4381 cttgtagttg tccttcggcg tctcgcccgc acagcccagg aaggtcttgt gcgaaccggg
     4441 catgatcatc agcccgccgt tggtgtcgaa gttctccgtc agcgcgatcg agacggacac
     4501 ggtccgcatg ttcggcagcc cgtcctcggc gtgccaggtc tcgaagtccg agtgccagta
     4561 gaagcccgag gcgccgaagc ccggcttcac attgatccgg gactggtgga cgtacacgtc
     4621 cgagcccagg atctggcggg cccggcccac cacccgctcg tcacggacca gcccggcgaa
     4681 gacctcgctg atccggtgga cctcgaagac ggaccggacg ttctgcgact gcttctcgac
     4741 gatcgagcgc tcgtcggcac ggatcagtgg gtcggcgatc agccggtcca gctccgcgcg
     4801 gtagacggcg acctcgtccg gggtgatgag ctggtcgacg gtgaggaagc cgtcgtactc
     4861 atagctctgg agatccttgg cggcgatcgg gcccggagcg cccggcgccg accagatgac
     4921 cgggtcctgg cggggagtgg tcatctcggc ggcgccgcgc gaggggtaga gatcggcgcg
     4981 tacttcggtg gtcatgcggt tcaggcctcc tcggtcagca gtgggtagac accgttctcg
     5041 tcgtggtcct cccgtccggt gacgggaggg ttgaagacgc acacgcagcg gaagtcggtc
     5101 ttgggccgca gggtgtgccg ctcatgcccg tccagcaggt acatcgtgcc gggcgagatc
     5161 cagtgggtct cgccggtctc gtcgttggtc agctcggcct cgccctcggt gcacaggacg
     5221 gcctcgatgt ggttcgcgta ccacatcgag gtctccgtac ccgcgtagag cacggtctcg
     5281 tggagggaga agccgacctt ctccttggcg agcacgatgc gcttgctctc ccaggtgccg
     5341 gacgcggcct tcacatgccg gtcggtgttc tcgatgtcct tgaacgatcg gacgatcacg
     5401 gtgagcggtg cctttctctc gtgctccgcc ccgggccgtg aggcccgggg cgcctcttct
     5461 ctcgcctgcc ccggccgggc cgggtcaggc cgtctcgcgg acgcagcggg ccagcgtgcg
     5521 caggccctcg tccagctcct cggtggtgat ggtcagcggc ggcagcagct tgacgacctc
     5581 gctctgcggg ccggaggtct ccagcaggag ccccagctcg aaggcgcggg cgcagaccgc
     5641 cgaggcgcgc gccgggtcct cgaactccat gccccagacc aggccccggc cgcggaactg
     5701 cgcggtcggc tcctcggcgc agatcgccag cagcgcctgc tcgacctgga ggccccgctc
     5761 cttggtctgc tgctccaccc ggccgtcggc ccagtaggcg tccagcgcgg cggcggccgt
     5821 gacgaaggcc gggttgttgc cgcggaaggt gccgttgtgc tcgcccggct cccagatgtc
     5881 cagctccggc ttgaacaggc agagcgacat cggcaggccg tagccgctga tggacttcga
     5941 cagcgtgacg atgtccggga cgatcccggc ctcctcgaag gagaagaagc cgccggtccg
     6001 gccgcagccc atctggatgt cgtcgacgat cagcagcatg tcctggcgct cgcacagctc
     6061 ctggagcgcg cgcagccact cggcgcgggc cacgttgatg ccgccctcgc cctggacggt
     6121 ctccacgatc acggcggcgg gcttgttgag cccggagccc tggtcctcca gcagccgctc
     6181 gaaccagagg aagtcgggga ccgtaccgtc gaagtagttg tcgaacggca tcggcgtgcc
     6241 gtgcaccagc gggatgccgg cgcccgcccg cttgaacgcg ttgccggtga cggcgagcga
     6301 gcccagcgac atgccgtgga acgcgttggt gaaggagacg acggactcgc ggcccttgac
     6361 cttacgggcc agcttcagcg ccgactcgac ggcgttggtg cccgtcgggc cggggaacat
     6421 caccttgtac ggcaggtcgc gcgggcgcag gatcacgttc tggaacgtct ccaggaaggc
     6481 gcgcttcgcg gtggtcgcca tgtccaggcc gtgggtgatg ccgtcgcgct cgatgtagtc
     6541 gatcagcgct cgtttcagca cggggttgtt gtggccgtag ttgagcgagc ccgccccggc
     6601 gaagaagtcc aggtaggagt ggccgtcctc gtcggtcagc cgggcgccct gcgcacggtc
     6661 gaacacggcg ggccagccgc ggcagtagct acggacctcc gactccaggg tctcgaagac
     6721 gctcagtgcg ggcggggtga tggtcacagc gggtctcctg cgtgaggggg tgtgacgggc
     6781 ggtgtggtcg gtgctcccgg ctccgtgggg gcggccggga ccgcgccgga tggtcggccg
     6841 gcgcgaaaag tcgtggggga ccgggcgtac gcgtgcggta cgccggtcgt ccgtgggtgg
     6901 acgggccgtg cggtcgtacg ggaccgtccg ggcgcgggca ttccgggcgg gccgggcggg
     6961 tcgtgtccgg gggtgtcccg gccgctgggc cgggcgcctc ggacgcccgg ggccgccgca
     7021 gcggtgcctc ggtgcctcgg ggctcagcgg tgccccgggc gcctcagccg gtgaacggac
     7081 ctatccggta gagcacctcg ggcaggtgcg tcccctcggg gaacatcccg ccgtcgaaga
     7141 gcacctcccg ctccagcgcc acgtcgtgcc gctgggcgta ggacgtgaac agccggtcgg
     7201 acgcggtgtt gtccggggtg atcgtcgtct cgatccagga gagcccctgg tcggcggcga
     7261 cccgggcggt cagcgcgtcc agcagcgtgg cggccagccc cttgccccgg tgcgccccgt
     7321 cgacggccac ctgccagacg accagggtct cggggcggtc gggccggatg tagccggtga
     7381 cgaaggcgat cggctcgccg tcctcgccac gggcgacggc ggacgtcgcg gcgaagtcac
     7441 ggcaccacag caggtagctg tacgaggagt tcaggtccag gacctcggag tcgcgggcga
     7501 tgcgccagat cgcggctccg tcctccactc gtggtgtgtc gatactcagg aattcgcttc
     7561 gggcacgggc aaaatctgct ggtgcggcgg tcatgggaat tgaatttacc cagcaaattt
     7621 cgaaattgca tcgaggcaag gggttgggtg gagcaccggt ctgtgttatc aggcgtgcgc
     7681 gagacctgcc gcgatcgggg tgcgattcag tgccctttgt cctgaatttt tcgggcataa
     7741 cgccgagctt gtggagtcgg tcacaagctg gtaactcctt tggaacgtgt ccgaatcatg
     7801 aagttcgggc cccggaaaaa ctttcgcgtt tagggaacgg gaaagcgggc agaagaatgc
     7861 ggggagctgc tttcgataaa gcagctcccc gcattctgaa tatcagaggc tcagaggccc
     7921 ggagaggttt ccgagaccgc gcgccgggca gcatcgaagt cgacctgccg acccgtggcg
     7981 cccagcgcct cccccagggc cgcgagcgag gacagcaccg cgctcgccgt cgcatccgcc
     8041 ccgtagtgat tgacccggat catctccttg gacagcgccc cgccgcccgc gacgagcggc
     8101 agcgaggggt ccgtcgccag cgcccgcgcg accagcgcgg cggcgtcggt ccccgccggg
     8161 gcgcgcagcg tcgtggccac cggagcggcg tcccgcgcct cgtggacgta cggctccaga
     8221 ccgccgccga gggccaccgc gcccgcccgg gtcgccgccg ctgccgcggc gtggcgggcc
     8281 atcaccttct ccaggccgtc cgcctcgatc cgctccaggc acgcgtccag gcccagcatc
     8341 tccagctgcg ccggggcgtg cgggagcgcc gtgcggccgg cgtcgatcca gcgctccttc
     8401 cagtccagga gcgagaggta ggagcggcgc ggggcggccg ggttggcggc gaaccgctcc
     8461 caggcccgcc cgctcaccga caccgccgag accccggccg gaccgcccat cgccttctgc
     8521 gcgccgatca cgcacaggtc cacgccccag gcgtccggca gcagcggctc ggcgcccacc
     8581 gaggcgaccg cgtccagcat gaagagcgcc ccgtgcgccc ggaccacctc accgatctcc
     8641 gcgaccgggt tggtgttgcc ggtggccgcc tccgcgtgca ccagcgagac gaagtcgatc
     8701 tccgggtgct cggcgagcgc ctcggcgacc tggtcggcgg tgaccgccgt gtggaagggc
     8761 acggtgaggt cgacgacctg ggcgccgcag tcccgcagcc agttgccgaa ggtctgcccg
     8821 taaggccccg tgaccacgtt cagcgcggtc gagccgggcc gggcaccgct gcggatgcac
     8881 ccctccagcg gcagcagcgc ctcgccctgg gtgatgacga cgtcctgccc ggtggcgagc
     8941 agcgcggcca cccgccgctc gatggccgcg aagcggtcgg cggtcagcgg ggggaggtcg
     9001 aggaaggggt gcgtcacggt ggggctctct tcgggtcgga tcgggtcggg tccgtggtcg
     9061 ggcggcggtc ctgcggagcg gctgacgccc ccctcgggga cgcgccgcgc gcgggggtgt
     9121 ccggtcggtc cccgacgccc ccctcgcagc ctaccgatgg cctcgtacag tgccgctatg
     9181 agtgatcagg tgcgcgatca ggagcggcag ccggtgctgc gcgtgaaggg gcgggtcctc
     9241 gtcggtccgg acgaggtgcg cgacgaactg tgggccgtcg acgggcggat cacctacgag
     9301 cggccgccgg gcgcggaggg ggcgcagacc gtgacggggt gggcgctgcc cggtctcgtc
     9361 gacgcgcact gccatgtggg gctggacgcg cacggcccgg tcgacgcggc cacggcggag
     9421 aagcaggcgc tcaccgaccg gggcgccggg accctgctcg tccgggacgc cggatcgccc
     9481 tccgacaccc gctggatcga cgaccgcgag gacctgccga agatcatccg ggcgggccgc
     9541 cacatcgcca ggacccgccg ctacatccgt aactacgccc atgagatcga gcccggcgac
     9601 ctcgtcgcgt acgtggcgcg ggaggcccgg cgcggggacg gctgggtcaa gctggtgggg
     9661 gactggatcg accgctccgc cggggacctc accgcctgct ggccgcgcgg cgaggtcgag
     9721 gcggccatcg cggaggcgca ccggctgggc gcccgcgtca ccgcgcactg cttcgcggag
     9781 gagtcgctgc gcgatctggt cgaggcgggc atcgactgca tcgagcacgc caccggcctc
     9841 accgaggaga ccgtcccgct cttcgccgaa cgcggggtcg ccatcgtccc gaccctggtc
     9901 aacatcgcca cgttccccga cctcgcggcg ggcggcgagg ccaagttccc ccgctggtcg
     9961 gcccatatgc ggcggctgta cgagcgccgg tacgacaccg tgcgcgccgc ctacgacgcc
    10021 ggcatcccgg tctacgtcgg caccgacgcg ggcggttcgc tggcgcacgg cctggtcgcg
    10081 ggcgaggtgg ccgagctggt gaaggcgggc atcccgccgc tggaggccct ctccgccacc
    10141 acatgggggg cgaggggctg gctggggcgg ccgggccttg aggagggcgc tccggcggac
    10201 ctggtcgtgt acgacgagga cccgcgcgcc gacgtccggg tgctggcggc cccgcgccat
    10261 gtggtgctga acgggcgggt ggtggggtga cccggaggcg gagccccgtg cggtgccggg
    10321 ttgaccgggg gtgacgtaac cggcccccgg ctcgttgaac ctccttgcgc gcccctcggt
    10381 acggtcgcac gccgttcgg
//
