LOCUS       NZ_CP011522            22743 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces sp. CFMR 7 strain CFMR-7 chromosome, complete genome.
ACCESSION   NZ_CP011522
VERSION     NZ_CP011522.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CFMR 7
  ORGANISM  Streptomyces sp. CFMR 7
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Complete genome sequence of Streptomyces sp strain CFMR 7, a natural
            rubber degrading Actinomycetes isolated from Penang, Malaysia
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8207742)
  AUTHORS   Sudesh,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2015) School of Biological Sciences, University
            Science Malaysia, Minden, Gelugor, Georgetown, Penang 11800,
            Malaysia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 147x
            Sequencing Technology             :: PacBio RS
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001278095.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 02:27:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,124
            CDSs (total)                      :: 7,038
            Genes (coding)                    :: 6,918
            CDSs (with protein)               :: 6,918
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 35 of 120
            Pseudo Genes (incomplete)         :: 96 of 120
            Pseudo Genes (internal stop)      :: 7 of 120
            Pseudo Genes (multiple problems)  :: 16 of 120
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3813537
            Orig. end                         :: 3836280
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011522.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22743
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="21"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22743
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22743
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12743](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12743)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(324..339)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(865..878)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(884..1279)
                     /locus_tag="ABE83_RS15725"
                     /old_locus_tag="ABE83_15755"
     CDS             complement(884..1279)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="ABE83_RS15725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15755"
                     /product="ATP-binding protein"
                     /protein_id="WP_159041087.1"
                     /transl_table=11
                     /translation="MRSTPAGQPMASEDRRRPGQLRRMNGALLTLWDLRPCIDVAALVL
                     TELVTNAFQHGGGEDITVTWCADVTHLTMRVEDSSPVRPVLRAVDETSEGGRGLGIVEA
                     LADAWGVSEDGRTVHCALALAEYAARA"
     gene            complement(1443..1712)
                     /locus_tag="ABE83_RS15730"
                     /old_locus_tag="ABE83_15760"
     CDS             complement(1443..1712)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ABE83_RS15730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ABE83_15760"
                     /product="hypothetical protein"
                     /protein_id="WP_053560043.1"
                     /transl_table=11
                     /translation="MSALPKYDPDCTWRAERVPDRPVMRVIDVQRQETYFDLSLVITFD
                     GSAQGPAYLRLEVDEVIDLVDELNFVLDVRVREPVAQPCTPSGS"
     gene            1828..2676
                     /locus_tag="ABE83_RS15735"
                     /old_locus_tag="ABE83_15765"
     CDS             1828..2676
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604542.1"
                     /locus_tag="ABE83_RS15735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15765"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_239009148.1"
                     /transl_table=11
                     /translation="MPKRASDSSGEASARKMLHETLKRLRDRSGLSLEELHDETTYDRS
                     YLHKLETGARLGSLEVMAALDKVYGTGEQLQQLWELARDDAFGSRYQRFMRLEREATVR
                     YEYACSAIPGLLQTRAYATEVLEHSPPRDAAELQEDVDARMSRQSVLVGEDAPYFRALL
                     DEAVFRRAASQPAAWLEQLEALLEWQKRPNVTLQLLPFSAGLHDLMGGSLTVLWLANGK
                     AVAYLEGSKSGELVEDSGRVEELRLSYDLQRDKALSPEQTTEFIQQLVKETRSCLPAEP
                     T"
     gene            2652..2849
                     /locus_tag="ABE83_RS15740"
                     /old_locus_tag="ABE83_15770"
     CDS             2652..2849
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540427.1"
                     /locus_tag="ABE83_RS15740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15770"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_053560044.1"
                     /transl_table=11
                     /translation="MPSRRADLTSATWRKSSYSNSDGGNCVEVSDDFPDLVPVRDSKQP
                     EGPAVIFGTSAWAAFVHDVR"
     gene            2976..3173
                     /locus_tag="ABE83_RS15745"
                     /old_locus_tag="ABE83_15775"
     CDS             2976..3173
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956755.1"
                     /locus_tag="ABE83_RS15745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15775"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_053560045.1"
                     /transl_table=11
                     /translation="MRSRRANLASATWRTSSHSNSDGGQCVEVADGLPGLVPVRDSKQL
                     EGPAVIFGASAWTAFVNDMR"
     gene            3271..3468
                     /locus_tag="ABE83_RS15750"
                     /old_locus_tag="ABE83_15780"
     CDS             3271..3468
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540427.1"
                     /locus_tag="ABE83_RS15750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15780"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_053560046.1"
                     /transl_table=11
                     /translation="MPSRRANLTSATWRKSSYSNSDGGDCVEVSDDFEDLVPVRDSKQP
                     EGPALVFGAPAWAAFVNDVR"
     gene            complement(3563..4849)
                     /locus_tag="ABE83_RS15755"
                     /old_locus_tag="ABE83_15785"
     CDS             complement(3563..4849)
                     /GO_function="GO:0000009 - alpha-1,6-mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004376 - glycolipid mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047360.1"
                     /locus_tag="ABE83_RS15755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15785"
                     /product="mannosyltransferase family protein"
                     /protein_id="WP_203228183.1"
                     /transl_table=11
                     /translation="MSMLSPGLRPAEPRSGATSAPRPSGPVGPVPYASDAPRRHRWASW
                     LTPADRRVLQLYLLTRLSLWIMAHGARWLFPRGSDVREAAPLLAPFQQWDANHYLHIAR
                     DGYFPAGAGPWLGDWDNREAFFPGYPFLLRAVHVVVPDWTAAGLLISLVAGAVAVLTLS
                     RTARSYVPEDAAGHRTVLSFLLSPCAVFLAVGYTEALFLAFALPAWLAARRHRWAWACA
                     LTALATTVRVSGLFLAAAIAVLFMLTALQAGSGKGKGRRTAWRGVAWLALPGLPPLAYS
                     WYLHAHTGDWMAWKHAQERGWYREFHTPWEAWANTWNAAFDGVHTTGYAAMFQAELAAM
                     VVGVALVAVLLRHRRRPEAVYVALSLWALGTSYWYTSVPRATLLWWPLWIGLAAVSLRR
                     PWFRTAYLCVSAPLSALVALAFFTGRWAG"
     gene            complement(4978..5559)
                     /locus_tag="ABE83_RS36065"
                     /old_locus_tag="ABE83_15790"
     CDS             complement(4978..5559)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126494.1"
                     /locus_tag="ABE83_RS36065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15790"
                     /product="hypothetical protein"
                     /protein_id="WP_053560047.1"
                     /transl_table=11
                     /translation="MSEPRDPSGPEEPRGAQDPLRTLFHQAGEFGQGRTVADPAAHITE
                     RGMRAQRRRMAALAVGVCLVVGGGGAAAIGLHPVTPAPAPPATSPSPSYPSPSPPPPAG
                     TVTEPPTPSMTVPGTQGSGSGAYPSGSYTPGSAVPGSSAPGGMPTTEAPTASSSATSTS
                     TGTSTGTSTGTPTGTPGSAPDSTLGATSMP"
     gene            complement(5552..6052)
                     /locus_tag="ABE83_RS15765"
                     /old_locus_tag="ABE83_15795"
     CDS             complement(5552..6052)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489040.1"
                     /locus_tag="ABE83_RS15765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15795"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_053560048.1"
                     /transl_table=11
                     /translation="MTVEEFEEFYARAVTRLTGQLYVMTGDLQEAQDVVQEAFVKAWVR
                     RGWLERDGQPEAWIRTVAWRLAVSRWRFRRRSADAWGRGSGAPEHVAPPDPDHVVLVEA
                     LRGLPAQQRRTLTLHYLCDLTVEQIAGETGLSASTIKTHLVRGRVALAHRLRDPRMEEA
                     PDV"
     misc_feature    6024..6037
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     misc_feature    6133..6148
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    6191..6204
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            6547..7389
                     /locus_tag="ABE83_RS15770"
                     /old_locus_tag="ABE83_15800"
     CDS             6547..7389
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489037.1"
                     /locus_tag="ABE83_RS15770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15800"
                     /product="hypothetical protein"
                     /protein_id="WP_203228184.1"
                     /transl_table=11
                     /translation="MAKPGYGKRSAPGERPRTDRDFAHLLPRDAAVAAYIDRLPDGSDI
                     SVKTLAKHLPYGQCALGTTLNRLQAAGHLRRGSECVVADDVMLWVTRTFFSRTAREDSW
                     WNAFTRGDAPPDRPQRPTRSRAFILLAALGRTAPTLSLSSADCVRLEPQVSEWFARGAT
                     EAELLHALTAGLPSPVHCAARLVERRLADKLPPERVPPGPEPRTVLRTLECGECGVPGS
                     PEALLGGLCRACRGPSPEPPVGPPGAVQPPGVRERMDAVRAGLVPRSERTYRFERTHR"
     misc_feature    6766..6768
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7446..8033
                     /locus_tag="ABE83_RS15775"
                     /old_locus_tag="ABE83_15805"
     CDS             7446..8033
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762767.1"
                     /locus_tag="ABE83_RS15775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15805"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_019762767.1"
                     /transl_table=11
                     /translation="MTPSPADHAPRAELSVEEFEQLARSAPETVTLELINGKLEVKPVP
                     DGDHGTIFMWLLRQCMQHRPDLDLHPEQGLMVEAYRQGRARPDGALAPRRHFAGQGEWA
                     PADGVLMTVEVTSYDHDTDHRDRTEKPHGYASAGIPVYLLIDRDSGTLVVHSEPDRGRY
                     RQQHSYDYGDRVTLPHPVSITLDTEELKDYAR"
     gene            complement(8065..9774)
                     /locus_tag="ABE83_RS15780"
                     /old_locus_tag="ABE83_15810"
     CDS             complement(8065..9774)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379740.1"
                     /locus_tag="ABE83_RS15780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15810"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239009316.1"
                     /transl_table=11
                     /translation="MLLARVRPHRGVLIRAGLLSLAGSAAGLAMPLMAKYAVDAFAADR
                     SPVAPLVALTALVLAGACLSAYGRYLMARTGEGVVLRARDQLVGRIMRLKVPAVDRLTP
                     GDLQSRVTSDTTLLRTVLSSGLVESFNSVLMLLGTVAFMAYMDLTLLGVTLVVIVGIGA
                     VTALLMPRIQRAQLRAQESVGAMGAALDRVLQAFRTVKASGAEERETAAVARAARHAHD
                     RGVSVAKWSSVSDVTMMMSIQLAFLAVLGVGGARVASGSLEISSLIAFLLYLFYLMGPI
                     GGLVEGWTGLQSGLAAVRRIDEVESLPGEPSEGSGGLKEGGGPLRVTFQDVTFGYGDER
                     APAHKGVTFDVPAGGMVALVGPSGAGKSTVFSLLERFYDHDAGTIALDGRDIRDWPLAE
                     LRASLAYVEQDAPVLAGTLRENLLFAAPDAPEERLTEAVTRTRLDALVARLPEGLDTAV
                     GHRGVTLSGGERQRIAIARALLRRPRLLLLDEVTSQLDAVNEQALRDVILELAAQSTVL
                     VIAHRLSTVRHADRIVVLEDGRVRTAGTHEELMAEDDLYRELATTQLAAEVQ"
     gene            complement(10001..10477)
                     /locus_tag="ABE83_RS15785"
                     /old_locus_tag="ABE83_15815"
     CDS             complement(10001..10477)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489034.1"
                     /locus_tag="ABE83_RS15785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15815"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_053560050.1"
                     /sec_met_domain="PF13471 (E-value: 9e-25, bitscore: 85.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDMTMPRRGAGPGGVRLRAAIAAAFVLARFKPGRLRRVLTRCS
                     RGARPATYDETLEMYEAVTATSRRCAGRYGCLPRSVAIVLACRMSGAWPDWCAGVRTAP
                     PFSPHAWVEAGGRTVGEQAEAADLRPLMVVTVREGVPGERGGGDDDGGGGGQEP"
     gene            complement(10474..10725)
                     /locus_tag="ABE83_RS15790"
                     /old_locus_tag="ABE83_15820"
     CDS             complement(10474..10725)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126488.1"
                     /locus_tag="ABE83_RS15790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15820"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_019762773.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.3e-25,
                     bitscore: 87.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-14, bitscore: 51.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRKGIAVTTTEYGGVLLDEKDGSYWQLNDTSVIVVEALAAGQT
                     PEAAVDRIVAEFDVERAEAESDVAELTRQLVEAKILRP"
     aSDomain        complement(10480..10725)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ABE83_RS15790_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="9.10E-28"
                     /identifier="RREFam002.1"
                     /label="ABE83_RS15790"
                     /locus_tag="ABE83_RS15790"
                     /protein_end="82"
                     /protein_start="0"
                     /score="87.1"
                     /tool="antismash"
                     /translation="MKLRKGIAVTTTEYGGVLLDEKDGSYWQLNDTSVIVVEALAAGQT
                     PEAAVDRIVAEFDVERAEAESDVAELTRQLVEAKILR"
     gene            complement(10722..12743)
                     /locus_tag="ABE83_RS15795"
                     /old_locus_tag="ABE83_15825"
     CDS             complement(10722..12743)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489032.1"
                     /locus_tag="ABE83_RS15795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15825"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_053560051.1"
                     /sec_met_domain="Asn_synthase (E-value: 5.8e-35, bitscore:
                     120.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGLLRDYFVVLPDSVAGHTVAGQLPAPEATGPASAPTMTGPVSA
                     PTGTGPVSAPTATGAASAPAATGAGTGDVLTVPHPSGRPWVLARPRFRKVSHLRRGNDA
                     LVLIGPDRVPEAVLAGLLEGARDRAALERRLARLPGLHHVIAHLSGETWIRGTASGLRR
                     MYHARHPQAGTIASDRPAVLAHLTGAPLDDGALALRMLDFLPHPLSRRALWRGVHETGA
                     GYGLALPVAAPGTAAAPGPREYRWWEPPPPELSLAEGARRVGEAVAASVRAHVGGLDRI
                     SCELSGGLDSTALTFAARATGPAELSLLTVAARDRYSEDETWARRAVEAAHGPTDALAH
                     HIIPADQAPYFYADLAATSAELNDEPLPVAPGRARAHLLLSHAHATGSRYHLTGYGGDE
                     LFLGLPHAYQDLFHGNPLTAWNHLSGLRHQLGWPLLPTLKALLNRSTFPQWLAGAVTTE
                     PQPVTRTPLLSWGVRQSLRPWFTDHARTLITEEFRTAAEQAEPIDRWRGRHVDIDAVRM
                     GARHFQAMEDIGMTIGLPVAAPFYDDRVLEATLAVRLPERISPWRYKPLLVEAMRGVVP
                     DALLARTTKDHMSSDEHQGLREHAPELADLWTGSRLAEHGLVDARHLLRLAAEPFSPVL
                     VEHSISSTVAGETWLRTAENAWPTPQLTPTTTTSEALQ"
     gene            complement(12794..12925)
                     /locus_tag="ABE83_RS36070"
     CDS             complement(12794..12925)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511015.1"
                     /locus_tag="ABE83_RS36070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_019762774.1"
                     /transl_table=11
                     /translation="MKQQEKAKKAYMKPSLFKQGDFSKKTAGYFYGSYKEYWVRRII"
     CDS_motif       complement(12845..12925)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKQQEKAKKAYMKPSLFKQGDFSKKTA"
                     /locus_tag="ABE83_RS36070_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(12794..12844)
                     /prepeptide="core"
                     /locus_tag="ABE83_RS36070_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="0.20"
                     /molecular_weight="2082.4"
                     /monoisotopic_mass="2081.0"
                     /core_sequence="GYFYGSYKEYWVRRII"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKQQEKAKKAYMKPSLFKQGDFSKKTA"
                     /leader_location="[12844:12925](-)"
     misc_feature    complement(13190..13205)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.0"
                     /tool="antismash"
     misc_feature    13360..13375
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.15"
                     /tool="antismash"
     misc_feature    complement(13361..13374)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            complement(13677..14240)
                     /locus_tag="ABE83_RS15800"
                     /old_locus_tag="ABE83_15830"
     CDS             complement(13677..14240)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762775.1"
                     /locus_tag="ABE83_RS15800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15830"
                     /product="hypothetical protein"
                     /protein_id="WP_053560052.1"
                     /transl_table=11
                     /translation="MGNTGPGSAGNGGPGRGERARWSGRQLKGAALVLAGALLFAVGGF
                     IVVTGTGLSKLVGMRVETFGRISCHDTRAEKGQTVWHCSGETPAQQRANDAERERAARD
                     ALRAHVDGMPKSAQIERSRITFADHDGRNDPETITATQVFEGGRWFAHSGQLFGYGMIP
                     LLGGAVMAAWGVYRVREAAGVRGR"
     gene            complement(14512..16134)
                     /gene="groL"
                     /locus_tag="ABE83_RS15805"
                     /old_locus_tag="ABE83_15835"
     CDS             complement(14512..16134)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133870.1"
                     /locus_tag="ABE83_RS15805"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15835"
                     /product="chaperonin GroEL"
                     /protein_id="WP_003967345.1"
                     /transl_table=11
                     /translation="MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGA
                     PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR
                     NVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEA
                     MDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVN
                     SKIGSVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGD
                     RRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSDQV
                     QGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR
                     NAKAAVEEGIVAGGGVALLQASAVFEKLDLTGDEATGANAVKLALEAPLKQIAVNGGLE
                     GGVVVEKVRNLPIGHGLNAATGEYVDMIAEGILDPAKVTRSALQNAASIAALFLTTEAV
                     IADKPEKAGAAAPGGMPGGDMDF"
     misc_feature    16286..16301
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.7"
                     /tool="antismash"
     misc_feature    16286..16304
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    complement(16288..16302)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    complement(16289..16304)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(16593..16799)
                     /locus_tag="ABE83_RS15810"
                     /old_locus_tag="ABE83_15840"
     CDS             complement(16593..16799)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967346.1"
                     /locus_tag="ABE83_RS15810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15840"
                     /product="cold-shock protein"
                     /protein_id="WP_003967346.1"
                     /transl_table=11
                     /translation="MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQ
                     RVEFEISQGQKGPQADMVKLAVG"
     misc_feature    complement(17002..17016)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.29"
                     /tool="antismash"
     gene            complement(17209..17487)
                     /locus_tag="ABE83_RS15815"
                     /old_locus_tag="ABE83_15845"
     CDS             complement(17209..17487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265553.1"
                     /locus_tag="ABE83_RS15815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15845"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_018489029.1"
                     /transl_table=11
                     /translation="MSVKVRIPTILRTYTGGQAEVPAEGATLAEVIESLEKDHPGIAAR
                     VLDDQGKLRRFVNVYVNDDDVRFEGGLDAATPDGAGISIIPAVAGGC"
     gene            complement(17522..18817)
                     /gene="thrC"
                     /locus_tag="ABE83_RS15820"
                     /old_locus_tag="ABE83_15850"
     CDS             complement(17522..18817)
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056010.1"
                     /locus_tag="ABE83_RS15820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15850"
                     /product="threonine synthase"
                     /protein_id="WP_078949693.1"
                     /sec_met_domain="PALP (E-value: 6.7e-61, bitscore: 204.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQTVAGNATTASVDLGPAVALSCRECGERFDLGPLFACASCFG
                     PLEVAYDLPAGDPEALRKRIEAGPDNIWRYAPLLPVPADVADKPNLNPGFTKLVKADNL
                     ARELGVTGGLYVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAA
                     ARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFV
                     NVNLRPYYGEGSKTLAYEICEQLGWRLPDQIVIPIASGSQLTKIDKGFQELIRLGLVED
                     RPYRIFGAQAEGCSPVSAAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGG
                     AVEDVNDEQVVDAIKLLARTEGIFGETAGGVTVGVTKKLIEAGVIDPALTTVVLNTGDG
                     LKTLDAVSATSQATATIKPSLDAFRAAGLASA"
     regulatory      complement(18836..18963)
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(19071..19091)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.36"
                     /tool="antismash"
     gene            19117..20067
                     /locus_tag="ABE83_RS15825"
                     /old_locus_tag="ABE83_15855"
     CDS             19117..20067
                     /EC_number="2.4.1.266"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511020.1"
                     /locus_tag="ABE83_RS15825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15855"
                     /product="glucosyl-3-phosphoglycerate synthase"
                     /protein_id="WP_053560054.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-09,
                     bitscore: 36.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEEVERWLTRRSWSSADRPLDRLLDARTAEPHRTSVSVVLPALN
                     EEATVGAIVATIRRELMEKVRLVDELVVIDSGSTDATAAVAHEAGARVVHRDAILPRIP
                     ALPGKGEVLWRSLLVTSGEIVCFVDADLKDFSADFVSGTVGPLLTDPTVHFVKAMYDRP
                     LGDTAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELG
                     LLVDALHTVGLDALGQVDVGVRRHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPALTQ
                     FERGAEGFVPRTHAVDTEERPPMREIAEYAERWAA"
     misc_feature    complement(19141..19156)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            20217..21617
                     /locus_tag="ABE83_RS15830"
                     /old_locus_tag="ABE83_15860"
     CDS             20217..21617
                     /EC_number="2.4.1.15"
                     /GO_function="GO:0003825 - alpha,alpha-trehalose-phosphate
                     synthase (UDP-forming) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101576.1"
                     /locus_tag="ABE83_RS15830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15860"
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_053560055.1"
                     /transl_table=11
                     /translation="MVTEHAEATAPSTAQVLVASNRGPITYTLGEDGTLDAKRGGGGLV
                     SGLSAVDDKLWVCAALGDGDREAVRRGVGEPGVRMLDIDAEVHADAYNGIANSVLWFVH
                     HLLYQTPVEPVFDAEFRRQWASYETYNRAFAQALAEEAGEGAAVLVQDYHLALVPGMLR
                     ELRPDLRIGHFSHTPWAPVDYFRLLPDDIGEQLLRGILGADRAAFLTRRWADAFIGCCT
                     EILGGTGRTRIGVHGLGADADFLRRRSREADVDERMAALREQVGENRKTIVRVDRTELS
                     KNIVRGLHAYRALLETHPEWRERVVHVAFAYPSRQDLAVYRDYTAAVQSLATEINGAYG
                     TESWTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDHGCALVLSRE
                     AGAYEELGQDAIVVNPYDVTGTAEALHEALSMGAEERTGRTKRLAEAATALPPQRWFLD
                     QLEALRQE"
     gene            complement(21675..22526)
                     /gene="otsB"
                     /locus_tag="ABE83_RS15835"
                     /old_locus_tag="ABE83_15865"
     CDS             complement(21675..22526)
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958814.1"
                     /locus_tag="ABE83_RS15835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ABE83_15865"
                     /product="trehalose-phosphatase"
                     /protein_id="WP_053560056.1"
                     /transl_table=11
                     /translation="MGSHSVHLPTPTTPAGREGLEAILQRPGRAVVALDFDGTLADIVP
                     DPEQARAHPGAAEALAALAPKVASIAVISGRPAGVAVRYGGFAGVTGLDHLVVLGHYGA
                     ERWDAATGTVNAPAPHPGVAEARAELPGVLHEFGAWHGTWIEEKGQAVAVHTRRADDPQ
                     AAFETLRGPLGELAARHGLILEPGRQVLELRPPGMDKGVALAEYVREVGAASVLYAGDD
                     LGDLAAFATVEKLRGAGAEGIPGLLVCSGSAEVPELAERADLLVPGPAAVVEFLAALAD
                     SL"
ORIGIN
        1 tggtcccggc tcggaacgcg aggaccaggt ccaggccgta tggtccccgc gcgtgcgggg
       61 gtggtcccgt cctgttccag ttcaaccggc cggacagcaa atggtccccg cgcgtgcggg
      121 ggtggtccct ggcaccggtc ggtgctgtgc cagctgctcg gatggtcccc gcgcgtgcgg
      181 gggtggtccc cgccggggtg ggtgctctgg ccgaaacaca gcatggtccc cgcgcgtgcg
      241 ggggtggtcc cgtcgtcacg gtgaggacgg agacggcgcg ctgatggtcc ccgcgcgtgc
      301 gggggtggtc ccccggacgg gcatcgcaga agctttcgac cgtgatggtc cccgcgcgtg
      361 cgggggtggt cccgccgcgt ccagaccggg cgcgtcgatg acgtaatggt ccccgcgcgt
      421 gcaggggtgg tcccgaggca ttcgggggcc gggacgcgga ggccttatgg tccccgcgcg
      481 tgcgggggtg gtcccaccgc gagcttctcc tccaaccgca cggtgtcatg gtccccgcgc
      541 gtgcgggggt ggtcccaccg cgagcttctc ctccaaccgc acggtgtcat ggtccccgcg
      601 cgtgcggggg tggtccctgg agaaggcccg taaaagcgcc acgcggtcga tggtccccgc
      661 gcgtgccggg gggacctcgg cggagccgac gaacgccccc atgcgctcgt tccccagggc
      721 gtgcgcaccc tccgaggcac cgcgaaggac ggccggcgga ggatgcgcag ccccgggtct
      781 ggcggcggca gccggcgctc ggtgcaggcg ctcagtggcc gtacgccccg cacaggcccc
      841 ggccgacacc ttccgccgct acggtcccgc agcgtcacgg aggtcacgct cgcgccgcat
      901 actccgcgag ggcgagcgcg cagtgaacgg tacggccgtc ctcgctgact ccccacgcgt
      961 cggccagcgc ctccacgatg cccagtcctc gaccgccctc cgaggtctcg tccacggccc
     1021 ggagcacagg acgcacggga gagctgtcct ccacccgcat cgtcagatgc gtgacgtcag
     1081 cacaccaggt gacggtgatg tcctctccgc ctccgtgctg gaaggcgttc gtcaccagct
     1141 ccgtgaggac gagcgcggcc acgtcgatgc agggtctcaa gtcccacagc gtgaggagcg
     1201 caccgttcat gcgccgcagt tgtccggggc ggcgccggtc ttccgacgcc atcggctgtc
     1261 cggcgggggt cgaccgcacg atgccaactt ggcatcgccg aatcatgggc gcacttctcc
     1321 cggcgtcgtc gtgaacctgc tgctcttgac gagcaggcac ggtggtggtc atgaggtcgc
     1381 gtcctccgag gtggtttccc gggcctgcgc cgcgtcgccg cgcgggccgc acgtgactcg
     1441 tgtcaggagc cggacggcgt gcacggctgt gccacgggtt ccctcacccg tacgtccagc
     1501 acgaagttca gctcgtccac gaggtcgatc acctcgtcca cttccagacg gaggtacgcc
     1561 ggaccctgcg cgcttccgtc gaaggtgatc accagcgaca ggtcgaagta cgtctcctgc
     1621 ctctgtacgt cgatgacgcg catgacgggt cgatcaggga cgcgctcggc ccgccaggtg
     1681 cagtcggggt cgtacttcgg tagtgcgctc atggctctca ccttccgtgc ggacttcgga
     1741 tctttctgtc acgagcatcg gcgttgctgg ctacgctcgg aagggggttt ctgtagccct
     1801 atccccccag gacacagggg agttggaatg cccaaacgcg cgtccgattc gagcggggag
     1861 gcgtccgccc gcaagatgct gcacgagacg ctgaagcggt tgcgggaccg gtccgggctg
     1921 agtctggagg agttgcacga cgagacgacg tacgaccggt cgtacctgca caagctggag
     1981 acgggggccc gcctgggctc gctggaggtc atggcggcgc tcgacaaggt gtacggcacc
     2041 ggcgagcaac tgcaacagct atgggagctg gcccgggacg acgccttcgg cagccggtac
     2101 cagcggttca tgaggctgga gcgggaagcg acggttcgat acgaatacgc gtgcagcgcc
     2161 attccgggac tgctccagac gagggcgtac gcgacggagg tgctggaaca ctccccgccc
     2221 cgtgacgcgg cggagctgca agaagatgtc gacgcccgta tgagccgcca gtccgtcctt
     2281 gtgggtgagg acgctccgta cttccgggca ctgctcgacg aagcggtgtt ccgccgggcg
     2341 gcctcgcagc cggccgcatg gctggaacag ctggaggccc tgctggagtg gcagaagcgg
     2401 ccgaacgtga cgcttcagtt gctgccgttc tcggcaggtc tgcacgatct gatgggcggt
     2461 tcactgacgg tcctgtggct ggccaacggc aaggccgtgg cctatctgga gggcagcaag
     2521 tccggcgagc tggttgagga ctcaggacgc gtcgaggagc tgcggttgtc ctacgatttg
     2581 cagcgagaca aggcgctctc tccggagcag acaaccgagt tcatccagca gttggtcaag
     2641 gagacccgat catgccttcc cgccgagccg acctgacttc cgcgacctgg cggaagtcct
     2701 cgtacagcaa ctccgacggc ggtaactgcg tcgaggtgtc cgacgacttc ccggacctcg
     2761 tcccggtccg cgactccaag cagccggaag gaccggccgt catcttcggc acctccgcct
     2821 gggccgcgtt cgtccacgac gtgcgctgag acctgccgac gccctgcggc tccccggcgc
     2881 tgcctgagtc ccagtggacc ccgccccggc ggggtccatg cgttgttcgc ccgaatccag
     2941 tcgctgcccc cgcagctgat caaggagatc cgagcatgcg atcccgccga gccaacctgg
     3001 cctccgcgac atggcgcacg tcctcgcaca gcaactccga cggcggacag tgcgtcgaag
     3061 tggccgacgg ccttccaggt ctcgtccccg tccgcgactc caagcagctg gaaggaccgg
     3121 ccgtcatctt cggcgcctcc gcgtggacgg cgttcgtcaa cgacatgcgc taagccccgc
     3181 ctgcgtcctg tggctccccg ccccggcggg gttcatgccc tgctcgcccg gtccagtcac
     3241 tgcaccacag ctgatcaagg agatccgagc atgccttccc gccgagccaa cctgacttcc
     3301 gcgacctggc ggaagtcctc gtacagcaac tccgacggcg gcgactgcgt cgaggtgtcc
     3361 gacgacttcg aggacctcgt cccggtccgc gactccaagc agcccgaagg accagccctc
     3421 gtcttcggcg cccccgcctg ggccgcgttc gtcaacgacg tgcgctgagc cctgccagca
     3481 cacgcctcaa gccctgcaga gtacgtgcga gttccctggt ccccgcgcga gcgaggacca
     3541 gcgcctgttg acgcccagcg ggtcaccccg cccaccgccc cgtgaagaac gccagggcca
     3601 ccagcgcgga cagcggggcc gagacgcaca ggtacgccgt acggaaccag gggcggcgca
     3661 ggctcaccgc cgccaggccg atccagagcg gccaccacag cagcgtggcg cggggtacgg
     3721 acgtgtacca gtacgacgtt cccagcgccc acaggctcag cgccacgtac accgcctccg
     3781 gccggcggcg gtgccgcaga agcacggcga ccaaggccac gcccaccacc atcgccgcca
     3841 actccgcctg gaacatggcc gcatagcccg tcgtgtgtac gccgtcgaac gccgcgttcc
     3901 aggtgttcgc ccacgcctcc cacggggtgt ggaactcccg gtaccagccg cgctcctgcg
     3961 cgtgcttcca cgccatccag tcgcccgtgt gcgcgtgcag gtaccagctg tacgccagtg
     4021 gcggcagccc gggcagcgcc agccaggcca ccccgcgcca ggccgtccgc cgccccttcc
     4081 ccttccccga acccgcctgg agcgccgtga gcatgaacag caccgctatc gccgccgcca
     4141 ggaacagacc actgacccgc accgtcgtcg ccagagccgt caacgcgcag gcccacgccc
     4201 accgatggcg ccgggccgcc agccaggccg ggagcgcgaa ggccaggaac agcgcctccg
     4261 tgtagccgac cgcgaggaag accgcgcacg gggagagcag gaaggacagg accgtacggt
     4321 gaccggcggc gtcctcgggg acgtacgagc gggctgtccg ggagagcgtc agcacggcca
     4381 ccgcccccgc gaccagcgag atcagcaggc ccgccgccgt ccagtccggg acgacgacat
     4441 ggaccgcccg caggaggaac gggtagcccg ggaagaacgc ctccctgttg tcccaatcgc
     4501 ccagccacgg gcccgcgccc gccgggaagt agccgtcgcg cgctatgtgg aggtagtggt
     4561 tcgcgtccca ctgctggaac ggggcgagca gcggcgccgc ctcccgtacg tccgagcccc
     4621 ggggaaacag ccaccgcgca ccgtgggcca tgatccacag ggacaggcgg gtcagcaggt
     4681 agagctggag caccctgcgg tcggccgggg tgagccagga tgcccaccgg tgtcggcggg
     4741 gcgcgtcgga tgcgtacggt acgggcccga ccggcccgct cggccggggc gcggaggtgg
     4801 cgcccgaccg gggctcggcc gggcgcaacc cgggggacaa catagacatt tgggcacctt
     4861 tcggacgctc ccagggcgcg cgggatcgcc cggatcgccc ggtggagccg ccggggcacg
     4921 gggaggggaa gagggagggg gcgtacaggg aggcggctca cccgccgccc tccgcgatca
     4981 cggcatcgac gtcgccccga gcgtcgaatc cggcgccgag ccgggcgtcc ccgtaggcgt
     5041 ccccgtagac gtccccgtag acgtccccgt agacgtcgac gtcgccgagg acgaagccgt
     5101 cggtgcctcc gtcgtcggca tgccccccgg cgcggacgaa ccgggcacgg ccgaaccagg
     5161 cgtgtacgaa ccggaggggt acgcccccga gcccgagccc tgcgtccccg gcaccgtcat
     5221 gctcggcgtc ggcggctccg tcacggttcc ggcgggtggc gggggcgagg gggacgggta
     5281 gctgggggac gggctcgtcg ccggaggggc cggggccggg gtgaccgggt ggaggccgat
     5341 cgccgccgcg ccgccaccgc cgaccaccag gcagaccccc accgcgagcg ccgccatccg
     5401 gcgccgctgg gcgcgcatgc cgcgttcggt gatgtgggcc gccgggtccg cgaccgtgcg
     5461 gccctggccg aactccccgg cctggtggaa cagggtcctc aacggatcct gcgcaccccg
     5521 gggctcctcc gggcccgacg ggtcccgtgg ttcagacatc aggagcctcc tccatgcggg
     5581 ggtcccgcag ccggtgggcg agcgccaccc ggccgcggac cagatgcgtc ttgatcgtgc
     5641 tggcggaaag cccggtctcc ccggcgatct gctcgaccgt gaggtcgcac aggtagtgca
     5701 gggtcagcgt ccgccgctgc tgggcgggca gcccgcggag cgcctcgacg agcaccacgt
     5761 ggtccgggtc cggcggcgcc acgtgctccg gcgcgccgct cccccggccc caggcgtccg
     5821 ccgaacgccg ccggaagcgc caccggctca ccgccaggcg ccacgcgacc gtacggatcc
     5881 acgcctcggg ctgcccgtcc cgctccagcc agccgcgccg gacccacgcc ttgacgaagg
     5941 cctcctgcac gacgtcctgc gcctcctgga ggtcccccgt catcacgtac aactggcctg
     6001 tgagacgcgt gaccgcccgg gcgtagaact cttcgaactc ctcgacggtc aaaagttgct
     6061 cccggatctt tcgcttcacc gggtatacgc ctaccgccgg gcgtccggtc tacagcgccc
     6121 gcggagtccg ccggtgacgg tcgtcacagc ccccggacgg ccgatccggg cagaggggac
     6181 cccagtgaat cgcacataag ttcccgcctg gcccaccggc gcccacctcg ccccaccccg
     6241 cgcacctccc ggagctcaag cggcgagatc cgagcgctct taacagtgat ggggtggatg
     6301 ggtcagttgt cccacccacc caccctgcga ccggagttga ccgcttgtga ccgacttgcg
     6361 acgcgccgtc gcgtggcttt agcgtgcgga gaacgagagc agaacaaaga cgacccctgc
     6421 tggtgatgga acaccgaaca ggggtctgac cagtgaagat cggacacaac gatccccatg
     6481 gctgacagct accttaatgc tgcctccggc accccgcacg aggccccgcc agcgtccccg
     6541 caccccatgg ccaaacccgg ctacggcaag cgctccgccc ccggcgaacg accgcgtacc
     6601 gaccgcgact tcgcccacct cctcccccgc gacgccgccg tcgccgccta catcgaccgg
     6661 ctgcccgacg gctccgacat ctccgtgaag acgctcgcca agcacctccc gtacgggcag
     6721 tgcgccctcg gcaccaccct caaccggctc caggccgccg ggcatttacg gcgcggcagc
     6781 gagtgcgtgg tggccgacga cgtgatgctc tgggtgaccc gtacgttctt ctcgcgcacc
     6841 gcccgcgagg actcctggtg gaacgccttc acccggggcg acgccccgcc cgaccggccc
     6901 caacggccca cccgctcgcg ggcgttcatc ctgctcgccg ccctggggcg tacggccccg
     6961 acgctctccc tctcctccgc cgactgcgta cggctggaac cgcaggtcag cgagtggttc
     7021 gcgcggggtg cgaccgaggc cgagctgctg cacgccctca ctgcgggcct gccgtccccc
     7081 gtccactgcg ccgcccgcct cgtcgaacgc cgcctggccg acaagctgcc gcccgaacgc
     7141 gtcccgccgg ggccggagcc acggaccgtc ctgcgcaccc tggagtgcgg cgagtgcggg
     7201 gtccccggca gcccggaggc cctcctcggc gggctgtgcc gcgcctgccg ggggccgtcc
     7261 cccgagccgc cggtgggtcc gccgggggcc gtgcagccgc ccggcgtacg ggagcggatg
     7321 gacgcggtac gggcagggct ggtcccccgc tcggagcgaa cctaccgatt cgagaggacc
     7381 caccggtgac cgtgcagctc atccgcagat tcggcagggc acgatggagg ggaggaggcg
     7441 acgccatgac ccccagcccc gccgatcacg caccacgggc cgagctgtcc gtcgaggagt
     7501 tcgagcagct cgcccgctcg gccccggaga ccgtgacgct tgagctcatc aacggaaagc
     7561 tagaggtcaa gcccgtgccc gacggcgacc acggaaccat cttcatgtgg ctgctccgcc
     7621 agtgcatgca gcatcggccc gacctggacc tgcatccgga gcaagggctg atggtcgagg
     7681 cgtaccggca ggggcgggcc cgtcccgacg gcgccctggc ccctcgccgg cacttcgccg
     7741 gacagggcga gtgggcaccc gccgacggcg tcctgatgac cgtggaagtg acctcctacg
     7801 accacgacac cgatcaccgc gaccgcacgg agaagcccca cggatacgcc tcggcgggca
     7861 tcccggtcta cctcctgatc gaccgcgact ccggcaccct cgtcgtccac agcgagcccg
     7921 accgaggtcg ctaccggcag cagcactcgt acgactacgg ggaccgggtg acgcttcccc
     7981 accccgtctc catcaccctg gacaccgagg agctcaagga ctacgcccgc tgacccctca
     8041 ccgcgctccc gcctccacct acgcctactg cacctccgcc gcgagctgcg tcgtcgccag
     8101 ttcgcggtag aggtcgtcct ccgccatcag ctcctcgtgc gtgcccgccg tgcggacgcg
     8161 gccgtcctcc aggaccacga tgcggtcggc gtggcggacg gtggagaggc ggtgggcgat
     8221 gaccaacacc gtggactgtg cggccagttc gaggatgacg tcgcgcagcg cctgttcgtt
     8281 gacagcgtcg agctgcgagg tcacctcgtc gaggaggagc aggcgcgggc ggcgcagcag
     8341 ggcgcgggcg atggcgatgc gctggcgttc gccgccggag agggtgacgc cccggtggcc
     8401 gaccgccgtg tccaggccct cgggcagccg ggcgaccagg gcgtccaggc gggtgcgggt
     8461 gaccgcctcc gtcagccgct cctcgggggc gtcgggggcc gcgaagagca ggttctcgcg
     8521 gagggtgccc gccaggaccg gggcgtcctg ttccacgtac gcgagcgagg cgcgcagctc
     8581 cgccaggggc cagtccctga tgtcccggcc gtccagcgcg atggtcccgg cgtcgtggtc
     8641 gtagaaccgt tccagcaggc tgaacaccgt cgacttgccc gcccccgacg ggcccaccag
     8701 cgccaccatc ccgccggccg ggacgtcgaa cgtgacgccc ttgtgggcgg gggcgcgctc
     8761 gtccccgtac ccgaaggtga cgtcctggaa ggtgacccgc agcgggccgc cgccctcctt
     8821 caacccgccg gatccctccg acggttcgcc cggcagcgac tccacctcgt cgatcctccg
     8881 tacggcggcg aggccgctct gcaaccccgt ccacccctcc accaggccgc cgatcgggcc
     8941 catcaggtag aagaggtaga gcaggaacgc gatcagcgag gagatctcca gggagcccga
     9001 cgcgaccctc gccccgccca cgcccagcac ggccaggaag gcgagttgga tcgacatcat
     9061 catcgtgacg tcggagaccg acgaccactt cgccaccgac acaccccggt cgtgcgcgtg
     9121 ccgggccgcc cgcgcgaccg ccgccgtctc ccgctcctcc gcgccgctcg ccttcaccgt
     9181 acggaacgcc tggagcaccc ggtccagggc cgcgcccatc gctccgaccg actcctgcgc
     9241 ccggagctgc gcgcgctgaa tgcgcggcat gagcaaggcg gttacggctc cgataccgac
     9301 gatcaccacc agcgtcacgc ccagcagcgt gaggtccatg tacgccatga acgcgaccgt
     9361 ccccagcagc atcagcacgc tgttgaacga ctcgaccagg ccgctggaga ggaccgtccg
     9421 gagaagggtc gtgtcgctgg tcacgcggga ctggaggtcg ccgggggtga ggcggtcgac
     9481 cgccgggacc ttcaaccgca tgatccggcc caccagttgg tcgcgcgcac ggaggacgac
     9541 gccttctccc gtacgggcca tgaggtaacg cccgtacgcg gagaggcacg cgcccgcgag
     9601 gacgagcgcg gtgagcgcga cgagcggggc cacgggcgag cggtcggcgg cgaacgcgtc
     9661 gaccgcgtac ttcgccatca gcggcatcgc cagcccggcc gccgacccgg cgagcgagag
     9721 caggcccgcc cggatcagga caccccggtg cgggcggacc cgggcgagga gcaggcggag
     9781 gggggagggg ccggtcgtac ccggtgcgcc ggtcgtgccc gtcgtgccgg atgtgccggt
     9841 ctcaccagcc gtgccggtcg tacctggcgt gccggacgcg ccggacgcgc ccgtcgtgcc
     9901 ggtggcgctc acttcggaaa gtggtgcgct cgcctcgggc cctcccggtt ccccaggcgc
     9961 cccaggcact ccccgccccc caggcccctc cggctgcccc tcagggctcc tgtccgcccc
    10021 cgcccccgtc gtcgtccccg ccaccgcgct cacccggaac cccctcgcgt accgtcacca
    10081 ccatcagagg acgcagatcg gccgcttccg cctgttcgcc gaccgtgcgg ccccccgcct
    10141 ccacccaagc atgcggcgag aacggcggtg ccgtccggac cccggcgcac cagtcgggcc
    10201 acgcccccga catccggcac gccagcacga tggccaccga gcggggcagg cagccgtaac
    10261 ggcccgcgca gcggcggctg gtggcggtga cggcctcgta catctccagc gtctcgtcgt
    10321 acgtcgccgg gcgcgcgccc ctgctgcagc gggtcagcac ccggcgcagg cggcccggct
    10381 tgaagcgtgc gagcacgaac gcggcggcga tcgcggcccg cagccgtacg cctcccgggc
    10441 ccgcgccccg gcggggcatg gtcatatcgg tggtcatggg cgcaggatct tcgcctcgac
    10501 gagctggcgg gtcagctcgg ccacgtccga ctccgcctcg gcccgctcga cgtcgaactc
    10561 cgcgacgatc cggtcgacgg ccgcctcggg ggtctgcccg gcggcgaggg cttcgaccac
    10621 gatgacgctg gtgtcgttca actgccagta gctgccgtcc ttttcgtcga gcaggactcc
    10681 gccgtactcg gtcgtcgtga cggcgatgcc ttttctgagc ttcactggag tgcctcgctg
    10741 gtggtggtcg tgggggtcaa ctggggtgtg ggccaggcgt tttccgctgt gcggagccag
    10801 gtctccccgg ccacggtgga gctgatggag tgctcgacca ggaccggcga gaagggttcg
    10861 gccgccagcc ggagcaggtg gcgggcgtcc accagtccgt gttcggccag gcgggagccg
    10921 gtccacaagt cggccagttc gggggcgtgt tcgcggagtc cctggtgttc gtcggaggac
    10981 atgtggtcct tcgtcgtacg ggccagcagc gcgtccggca ccaccccgcg catcgcctcg
    11041 acgagcagcg gcttgtagcg ccaggggctg atccgctccg ggaggcgtac ggcgagggtg
    11101 gcctccagga cccggtcgtc gtagaagggg gccgcgaccg gcagcccgat cgtcatgccg
    11161 atgtcctcca tcgcctggaa gtgccgcgcc cccatccgta cggcgtcgat gtccacatgc
    11221 cgcccccgcc accggtcgat cggctcggcc tgctcggcgg cggtccggaa ctcctcggtg
    11281 atcagggtgc gtgcgtggtc cgtgaaccag gggcgcaggg actggcggac gccccaggag
    11341 agcagcgggg tgcgggtgac cggctggggt tcggtggtga ccgctcccgc cagccactgc
    11401 gggaaggtgg agcggttcag cagggccttg agggtgggga gcaggggcca gccgagctgg
    11461 tggcgcaggc cgctgaggtg gttccaggcg gtgagggggt tgccgtggaa gaggtcctgg
    11521 taggcgtggg gcaggccgag gaagagttcg tcgccgccgt agccggtgag gtggtagcgg
    11581 gatccggtgg cgtgggcgtg gctcaggagc aggtgcgcgc gggcgcggcc gggggcgacg
    11641 gggagcggtt cgtcgttcag ctcggccgag gtggcggcca agtccgcgta gaagtacggg
    11701 gcttggtcgg ccgggatgat gtggtgggcc agggcgtccg tggggccgtg tgccgcctcc
    11761 accgcccttc tcgcccacgt ctcgtcctcg ctgtagcggt cccgggcggc cacggtgagc
    11821 agcgacagct ccgccgggcc ggtcgcgcgg gcggcgaacg tgagggccgt ggagtccagg
    11881 ccgccggaga gttcgcagct gatccggtcc aggccgccga catgggcccg tacggaggcg
    11941 gcgacggcct ccccgaccct gcgggcaccc tccgccaggg agagttccgg cggcgggggc
    12001 tcccaccagc ggtactcgcg agggccgggg gcggcggccg tgcccggtgc tgcgacgggc
    12061 agggccagtc cgtacccggc cccggtctcg tgcacgcccc gccacagggc acgccggctc
    12121 agggggtgcg gcaggaagtc gagcatgcgc agggccagcg cgccgtcgtc caggggggcg
    12181 ccggtcaggt gggccaggac ggccgggcgg tccgaggcga tggtcccggc ctgcgggtgc
    12241 cgggcgtggt acatccggcg cagtccggag gcggtgcccc ggatccaggt ctcgccggag
    12301 aggtgggcga tgacgtggtg gaggccgggg agccgggcga ggcgccgttc cagcgcggcc
    12361 cggtcgcggg cgccctccag gaggccggcg agcacggcct cggggacgcg gtcggggccg
    12421 atgagcacga gggcgtcgtt gccccggcgg aggtggctga ccttgcggaa gcgggggcgg
    12481 gcgaggaccc aggggcggcc ggaggggtgc gggacggtca ggacgtcacc ggtcccggcc
    12541 ccggtcgccg cgggggcgga tgcggccccg gtcgccgtcg gggcggatac gggcccggtc
    12601 cccgtcggag cggatacggg cccggtcatc gtcggggctg acgcaggccc ggtggcctcc
    12661 ggtgcgggaa gctgcccggc caccgtgtgg cccgccacgc tgtccggcag gacgacgaag
    12721 tagtcacgca gcaggccggg catcttcacc tttcggaagt tctcacaccg tgcacaggga
    12781 accggtcggc ggttcagatg atgcgccgga cccagtactc cttgtacgag ccgtagaagt
    12841 aaccggcggt cttcttcgaa aagtcgccct gcttgaacag cgacggcttc atgtaggcct
    12901 tcttggcctt ctcctgctgc ttcatgacac cttcccttct gtgcggttga cgaccgttat
    12961 gcccaacagc tgttcgcata actggagtta ttggtgcggc tggtgttcac caggtgatca
    13021 ccagagccat catgtcccgc tgccggaccg gtacgcgtga ttccgactta ccgcgcgaag
    13081 ttggccggat agcgcgagcg gaaaaggcac ggtcgcgacc gttcgcaccg ccgccgaggc
    13141 accgaccggt cggcatgtgc agtcgcacac cggcgaggtg gtccggtgca gtggactgga
    13201 ccaataacta cggacggtgg cccgaccctg gcagtgagca gccaagagat cgcgcgcggc
    13261 gcggcggaac ggaggaacca gcggggcggg gccccggcaa cggctgcacc ggccctacct
    13321 cacgtacggt cggcgcgcca ccgacatcag cgaaaccgct cgaacgtgtg ttgccgtacg
    13381 gtgccgggca cggcaagtag ccattcggcc atgcccgacc gctcgttcgg ttccgtccgg
    13441 ggccgctcgg gcacgccgag gccccatcgg agcccatccg cgcccgcccg aggcccgtcc
    13501 gggcacgctg aacgccccgt cggagcgttc ccggagcccg ccagaagccc gccaggagcc
    13561 cgccaggagc ccgcccgggc ccaccgcgag cacgccacga gccagccgcg agcccgcagg
    13621 ggcgcccgcc gaggcgtccg ccggagaggc gcccgccgag gcgttcgcag cagccctcag
    13681 cggccccgca ctcccgccgc ctcacgtacc cggtagacgc cccacgccgc catcacggcg
    13741 ccccccagga gcgggatcat gccgtagccg aagagctggc ccgagtgcgc gaaccaccgg
    13801 ccgccctcga agacctgggt cgcggtgatc gtctcggggt cgttgcggcc gtcgtggtcc
    13861 gcgaaggtga tccggctccg ttcgatctgc gccgacttgg gcatgccgtc gacgtgggcg
    13921 cgcagggcgt cccgggccgc cctctcgcgc tccgcgtcgt tggcgcgctg ctgggccggg
    13981 gtctccccgg agcagtgcca gacggtctgc cccttctcgg cacgcgtgtc gtggcacgag
    14041 atccggccga aggtctccac ccgcataccg accagcttcg agaggcccgt gccggtcacc
    14101 acgatgaacc cgcccaccgc gaacaggagc gcccccgcga ggaccagcgc ggcgcccttg
    14161 agttgccgcc cgctccaccg cgcgcgctcc ccgcgccccg gcccgccgtt gcccgcgctc
    14221 cccggccccg tgttccccat agccgccatg gccgccccgc ccccgttcgc gtgccgcccg
    14281 cgtcccccgc gcgcgtacca accgttcccg tacaaaccgt tggaccgtcc ccacgttctg
    14341 acggttcccg cacggtccgg ttcccgcatt ctcccaggca ccccgggcac gccacagggg
    14401 cggcacctcc cgtgtgggag ataccgcccc tgtgggacgt acctgcgtac gcgacgtacg
    14461 tgacgtaccc gtcgtacgcg gaccctcgat cgaccggcgg accggaaccg atcagaagtc
    14521 catgtcaccg cccggcatgc cacccggggc ggccgcgccg gccttctcgg gcttgtcggc
    14581 gatgacggcc tcggtggtga ggaagagcgc ggcgatggag gcggcgttct gcagggcgga
    14641 gcgcgtgacc ttcgccgggt cgagaatgcc ctcggcgatc atgtcgacgt actcacccgt
    14701 cgcggcgttg aggccgtgac cgatcggcag gttgcggacc ttctccacga cgacgccacc
    14761 ctcgagacca ccgttgacgg cgatctgctt gagcggggcc tccagcgcga gcttcacggc
    14821 gttggcgccg gtcgcctcgt cgcccgtgag gtcgagcttc tcgaagacgg ccgaggcctg
    14881 gagcagggcc acgccaccac cggcgacgat gccctcctcg acggcggcct tggcgttgcg
    14941 caccgcgtcc tcgatgcggt gcttgcgctc cttgagctcc acctcggtgg cggcgccggc
    15001 cttgatgacg gccacgccgc cggccagctt cgcgaggcgc tcctggagct tctcgcggtc
    15061 gtagtccgag tcggagttct cgatctcggc gcggatctgg ttgacgcggc cctggacctg
    15121 gtcgctgtca ccggcaccgt cgacgatggt cgtctcgtcc ttggtgatga cgaccttgcg
    15181 ggcgcggccg agcaggtcga gaccggcgtt ctccagcttg aggccgacct cctcggagat
    15241 cacggtgccg ccggtgagga tggcgatgtc cgcgagcatg gccttgcggc ggtcgccgaa
    15301 gcccggggcc ttgacggcga cggacttgaa cgtgcccttg atcttgttga cgaccagggt
    15361 ggagagcgcc tcgccctcga cgtcctcggc gatgatcagc agcggcttgc ccgactgcat
    15421 gaccttctcc agcagcggga tgaggtcctt gacgctgccg atcttcgagt tgacgatcag
    15481 gatgtacggg tcgtcgagcg acgcctccat acgctccatg tcggtcgcga agtaggccga
    15541 gatgtagccc ttgtcgaagc gcataccctc ggtgagctcc agctccagac cgaaggtctg
    15601 ggactcctcg acggtgatga cgccttcctt gccgaccttg tccatcgcct cggcgatctt
    15661 cgcgccgatc tcggtgtcgg cggcggagat ggaggcggtc gaagcgatct gctccttggt
    15721 ctccacgtcc ttggcctgct ccagcagagc ggcggagacg gcctcgacgg ccttctcgat
    15781 gccgcgcttg agggccatcg ggttggcgcc cgcggcgacg ttgcgcagac cctcgcggac
    15841 gagagcctgg gcgaggacgg tggcggtggt cgtaccgtcg ccggcgacgt cgtccgtctt
    15901 cttggcgacc tccttgacca gctccgcacc gatcttctcg tacgggtcct cgagctcgat
    15961 ctccttggcg atggagacac catcgttggt gatcgtgggc gcgccccact tcttctcgag
    16021 gacgacgtta cggcccttgg ggccgagggt gaccttgacg gcgtcggcga gctggttcat
    16081 cccgcgctcg agaccgcgcc gtgcctcctc gtcgaacgcg atgatcttgg ccatgtgaag
    16141 tggtcctccc ggacaggggt ggattgctcc ggaccgagag gcgcccgcga cggacggcct
    16201 gcgtgcgtgg tggttccttg ccccatcacg cgtgcgggcc tcaccggccc ggtccaagtt
    16261 ctgtcactct cacctggaga gtgctaatgc caatgattag cactcgaccc ccgagagtgc
    16321 aagcgccttc gacgagagcc cgccatgcgg tcccgggtcg gtccccgccc gatccgggac
    16381 cggtccggaa ccgatccggg cgtcctcgca ggccggttcg ggcaccctca cgggtcggtc
    16441 cgggcgcccc cacgggccgg tccgggcgtg cccacaggtc ggtccgggcg gtgcccgcag
    16501 gtcggccccg gcacgcgcgt agggcccgat ccccggatgc cggggtcggg ccctacgtgc
    16561 gtgagtagtg acggcggacg gccgtgtcgg gctcagccga cggcgagctt gaccatgtct
    16621 gcctggggcc ccttctggcc ctgcgagatc tcgaattcaa ctcgctgacc ctcttcgagg
    16681 gtgcggtacc cgtccatctg gatcgcgctg tagtggacga aaacatccgc accaccgtcg
    16741 accgcgatga agccgtaccc cttctccgcg ttgaaccact tgacggtgcc ctgagccatg
    16801 cctaactccc ctataactgg cccttgcacg ggaccgcgct tcgcggcccc gggtcggaac
    16861 tcaccctccg acaggagagg gtgcgcagcg ccgcagcgcg tcgaccgcgg ccgaatgtat
    16921 ccgcccaact gccctctgca acaggtcaat cggacgagaa ttctgggcac ggccgaacgc
    16981 ccgaatatgc gggattgctg aaatttacgg gcaagtcggg ccaggcaaag gccacttatg
    17041 cctcaagggg ttcacgcact ttggctgctt cttatcgggt ccgggcgcat tctcatatgc
    17101 gggcggcgcg tgcagcgaag ggggtttccc caactgtacc gtgctcaacc atgcagaatt
    17161 gccccctcct ccccgagggg cggagggggc aatggtgttc gtacgggttc agcagccgcc
    17221 ggccacggcg gggatgatcg agataccggc gccgtccggc gtggccgcgt ccaggccgcc
    17281 ctcgaagcgc acgtcgtcgt cgttgacgta cacgttcacg aagcggcgca gcttgccctg
    17341 gtcgtccagg acgcgggcgg cgatgcccgg gtggtccttc tccagggact cgatgacctc
    17401 ggccagcgtg gcgccctcgg ccgggacctc ggcctggccg ccggtgtagg tgcggaggat
    17461 ggtggggatg cggaccttga cgctcatgac ggaggccttt ctgctgctgc ggtcggggtg
    17521 atcaggcgga ggcgaggccc gcggcgcgga acgcgtccag gctcggcttg atggtggccg
    17581 tcgcctgcga ggtcgcggag accgcgtcga gcgtcttgag cccgtcaccg gtgttcagga
    17641 cgacggtggt gagcgccggg tcgatcaccc cggcctcgat cagcttcttc gtcacgccga
    17701 ccgtcacacc gcccgccgtc tcaccgaaga tgccctcggt gcgcgccagc agcttgatcg
    17761 cgtcgacgac ctgctcgtcg ttgacgtcct ccaccgcgcc gcccgtgcgg cgggcgatgt
    17821 ccaggacgta cgggccgtcc gccgggttgc cgatggccag ggacttggcg atggtgttcg
    17881 gcttctgggg ccgtacgacg tcgtgcccgg ccttgaaggc ggcggagacc ggggagcagc
    17941 cctcggcctg ggcgccgaag atcctgtacg ggcggtcctc gaccaggccg agcctgatca
    18001 gctcctggaa ccccttgtcg atcttcgtca gctgggagcc ggacgcgatc gggatgacga
    18061 tctggtcggg cagccgccag ccgagctgct cgcagatctc gtacgccagg gtcttggagc
    18121 cctcgccgta gtacggccgc aggttgacgt tgacgaagcc ccagccctcg ccgagcgggt
    18181 ccccgatcag ctcggagcag aagcggttca cgtcgtcgta gttgccctcg atgccgacca
    18241 gctcaccgcc gtacaccgcg gccatgacga ccttgccctg ctccaggtcg tgcgggatga
    18301 agacgcagga gcgcagtccg gcgcgggcgg cggcggcgcc gacggcaccg gccaggttgc
    18361 ccgtggagga gcaggagaga gtggtgaaac cgaaggcgcg ggcggcctcg acggcgatcg
    18421 cgacgacgcg gtccttgaag gagtgcgtcg ggttgccgga gtcgtccttg acgtacagac
    18481 cgccggtgac gcccagctcg cgggcgaggt tgtcggcctt gaccagcttg gtgaagcccg
    18541 ggttcaggtt gggcttgtcg gccacgtcgg cggggaccgg cagcagcggg gcgtagcgcc
    18601 agatgttgtc gggaccggcc tcgatgcgct tgcgcagcgc ctccgggtca ccggccggca
    18661 ggtcgtacgc cacttccagc ggcccgaaac aggacgcaca ggcgaaaagg gggccgaggt
    18721 cgaaacgctc gccgcactcg cggcaggaaa gcgccacggc gggaccgagg tccacggaag
    18781 cggtggtggc attacctgcg acggtctgaa cagccatgat ggcggaggcc ctttctcctc
    18841 atcttcctcg cagcgcattt cgccgcaaga cggaattggc accttcccca ccgtgacctc
    18901 gcggtcggca ggagggttgc cgggacttca acgggccgtt ccctcagtcc ctctggatga
    18961 gctctgtggc actggatctt cgatccaggc gtttgtgtga cgacggaccc cgacatgcga
    19021 cggtcgtccg cgttgttcaa gactgtaacc gaaggacggg acggttgaga tagtcgtccg
    19081 aacggcgaga tggatcacac acagggagtt cagaccgtgc tcgaagaggt ggaacgctgg
    19141 ctgaccaggc ggtcctggtc gtccgccgac cgcccgctgg accggctcct cgacgcccgg
    19201 accgccgaac cgcaccgcac ctcggtgagt gtggtgctgc ccgcgctgaa cgaggaggcc
    19261 acggtcggtg cgatcgtggc gacgatccgg cgggagctga tggagaaggt ccggctggtg
    19321 gacgaactgg tggtgatcga ctccggttcg accgacgcca ccgccgccgt cgcccacgag
    19381 gcgggcgccc gggtggtcca ccgggacgcg atcctgcccc ggataccggc cctgccgggc
    19441 aagggcgagg tgctctggcg gtcgctcctg gtgaccagcg gggagatcgt ctgcttcgtc
    19501 gacgcggacc tcaaggactt ctcggcggac ttcgtctcgg ggacggtcgg cccgctgctc
    19561 accgatccca cggtgcactt cgtcaaggcg atgtatgacc gtccgctcgg tgacaccgca
    19621 ggtcagggcg gtcgcgtcac cgagctggtg gcccgcccgc tgctcaatct gcactggccg
    19681 caactggccg ggttcgtcca gccgctgggc ggggagtacg cggtgcggcg ctcgctgctg
    19741 gagcggctgc cgttcccggt cggttacgga gtggagctgg ggctcctggt cgacgcgctg
    19801 cacaccgtgg gtctggacgc gctgggccag gtcgacgtgg gggtgcggcg ccaccgccac
    19861 caggacgggc aggcgctggg ccggatggcg gcggcgatct accgcacggc ccagctccgg
    19921 ctctcccggg gccatctggt gcggcccgcg ctgacgcagt tcgagcgggg cgcggagggg
    19981 ttcgtgccgc gcacccatgc ggtggacacg gaggagcggc cgccgatgcg ggagatcgcg
    20041 gagtacgcgg agcggtgggc ggcgtgaggc gtacgcgggg cttcggcagc cctgaggcgt
    20101 gcgcgggcga gtcggccggc gtgaggcgta cgcgggcgca gtgggccgcg tgatgccggt
    20161 ggccggtcct ccggacgcgc gtttggcggc ttcccttacg ggctaggttc cgctacatgg
    20221 tcaccgagca tgccgaagcc accgccccgt ccaccgccca ggtcctcgtc gcgtccaacc
    20281 gcggccccat cacgtacacg ctcggcgagg acggaacgct cgacgccaag cgcggcggcg
    20341 ggggtctcgt ctccgggctg agcgccgtcg acgacaagct gtgggtctgc gcggccctcg
    20401 gggacggcga ccgcgaggcg gtgcggcgcg gggtcggtga gccgggcgta cggatgctgg
    20461 acatcgacgc cgaggtgcac gccgacgcgt acaacggcat cgccaactcc gtgctgtggt
    20521 tcgtccacca cctgctgtac cagacccccg tggagccggt cttcgacgcg gagttccggc
    20581 gccagtgggc ctcgtacgag acgtacaacc gggccttcgc ccaggcgctc gcggaggagg
    20641 cgggggaagg ggcggcggtg ctcgtccagg actaccacct ggccctggtc cccgggatgc
    20701 tccgcgagct gcgcccggac ctgcggatcg gccacttctc gcacaccccg tgggcgccgg
    20761 tggactactt ccggctgctg cccgacgaca tcggtgagca gttgctgcgg ggcatcctcg
    20821 gcgcggaccg ggccgcgttc ctgacccggc ggtgggcgga cgcgttcatc ggctgctgta
    20881 cggagatcct cggcgggacg ggccggaccc ggatcggggt gcacgggctg ggggcggacg
    20941 cggacttcct gcgccggcgc tcgcgcgagg cggacgtgga cgagcggatg gcggcgctgc
    21001 gggagcaggt gggcgagaac cggaagacga tcgtgcgggt ggaccgcacg gagctgtcca
    21061 agaacatcgt gcgcggcctg cacgcctacc gggccctgct ggagacccac cccgagtggc
    21121 gcgagcgcgt ggtccacgtc gccttcgcct acccctcccg ccaggacctc gcggtctacc
    21181 gggactacac ggcggcggtg cagtcgctgg ccacggagat caacggggcg tacgggaccg
    21241 agagttggac gcccgtcgtc ctccacgtga aggacgactt cgcccgctcg ctcgccgcgt
    21301 accggctggc ggacgtggcc ctggtcaacc cgatccgcga cgggatgaac ctggtcgcca
    21361 aggaggtccc cgtcgtctcc gaccacggct gcgcgctggt gctgtcgcgg gaggcggggg
    21421 cgtacgagga gctgggccag gacgcgatcg tggtgaaccc gtacgacgtg acgggcacgg
    21481 cggaggcgct gcacgaggcc ctgtcgatgg gcgccgagga gcggacgggc cgcacgaagc
    21541 ggctggcgga ggcggcgacg gcgctcccgc cgcagcggtg gttcctggac cagttggagg
    21601 cgctgcggca ggagtgaggg gagctgctca ctgcgctccc ggcacttccg tacggctacg
    21661 gctacggcta cggctcagag gctgtcggcc agcgccgcca ggaactccac cacggcggcc
    21721 ggtcccggca ccaacaggtc ggcgcgctcg gccagttcgg gcacctcggc gctgccgctg
    21781 cacaccagca gccccgggat tccttcggcg cccgcgcctc gcagcttctc cacggtggcg
    21841 aaggcggcga ggtctccgag gtcgtcgccc gcgtacagca cggaggcggc gcccacctcc
    21901 cgtacgtact ccgcgagcgc gacgcccttg tccatgcccg gcgggcgcaa ctccaggacc
    21961 tggcggcccg gttcgaggat cagcccgtgg cgggcggcca gctcgccgag ggggccgcgc
    22021 agggtctcga aggccgcctg cgggtcgtcg gcgcggcggg tgtggacggc gacggcctgg
    22081 cccttctcct cgatccaggt gccgtgccag gcgccgaact cgtgcagtac gcccgggagt
    22141 tcggcccgcg cctcggccac accggggtgc ggggcggggg cgttcacggt gccggtggcg
    22201 gcgtcccagc gctcggcgcc gtagtggccg aggacgacga ggtggtccag accggtgacg
    22261 cccgcgaagc cgccgtaccg tacggccacg cccgcggggc ggccgctgat cacggcgatc
    22321 gaggcgacct tcggggcgag cgcggccagc gcctcggcgg cgccggggtg ggcgcgggcc
    22381 tgctcggggt cggggacgat gtccgcgagc gtgccgtcga agtcgagagc gacgaccgcg
    22441 cggccgggcc gctggaggat ggcctccagg ccctcccgtc cggccggggt ggtcggggtc
    22501 ggcagatgta cggagtggct gcccatgggg tgagcctagc aatccggccc gtcagcgcag
    22561 gccccgccga gcgcatccac cctcctcaaa cgccggaggg gcttgaattg cgcccccgag
    22621 ggccgtcacc gtctcccccg gcgctcctcc ttcaggcggc ggaggcggtt caccgtgacc
    22681 gggtcctccc gcagcgcccg ctcgtcctcg atcagcgcgt tgaggagctg gaagtaccgc
    22741 acc
//
