LOCUS       NZ_CP012382            24724 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7629725
            Orig. end                         :: 7654449
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24724
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="27"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24724
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24724
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14724]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14724
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(721..732)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            950..2551
                     /locus_tag="SAM23877_RS33565"
                     /old_locus_tag="SAM23877_7069"
     CDS             950..2551
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523854.1"
                     /locus_tag="SAM23877_RS33565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7069"
                     /product="family 20 glycosylhydrolase"
                     /protein_id="WP_053141389.1"
                     /transl_table=11
                     /translation="MDVVIPGPANRTAAATGEALGLAGPWRVATTDHRLTAVAGTVRAL
                     LAPHLGDRLLPPDTTGTTATTLELVLDAASSAPHRAPVGISPRGTAEPGDESYRITVDE
                     HGVRCRSTTPEGVFRAATTALQTLAAATGPVPRGELTDAPHYAWRGLMVDPARGFLTPA
                     ELRRVVDLAALYKLNVLHLHLTDNEGWRLPLPAAAATGGPDAAARQYYIPDDYRALQAY
                     AAERFVTVVPEIDLPGHCAALREAVPGLPAAPAPEGLKGRFPYVPPLDLADPDTRSLVA
                     SVLTEVCELTDGPFVHVGGDEAVGMTADSFALAVRELRALVRAAGKHPLAWQEASRAGM
                     TANDIAQFWVDVPMMDLPDTQEELDRRPELLAAGYTPELVRALKRFFAPTDDDLARILD
                     GGGRVLLSPQSHLYLDRRYAPDIVPPGQAEDAARLGFATYRPRGVRHTAAWDPAAYGIP
                     EERIAGIAATVFGESIQGLDDLTTLLLPRLPSVAHTAWTGRAPDWDAHRDRVARHGRLW
                     EDRGLSYLASTEIPWA"
     gene            2632..3349
                     /locus_tag="SAM23877_RS33570"
                     /old_locus_tag="SAM23877_7070"
                     /pseudo=""
     CDS             2632..3349
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978600.1"
                     /locus_tag="SAM23877_RS33570"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7070"
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MITTDFVPGSPCWLDLGTPDVRGAAAFYGAVFGWDFESMGEDVEG
                     GMFRKDGKIVAGIGRLTEEGARSAWMVYYCVADADATTRAVRQAGGTVRVAPMDLDQWG
                     RMAQYSDPAGGQFAAWQPGTSQGVELVDQPGSLCWTELYTSDAAAAKEFYGTVFGWQFG
                     DMEMPDGGGGTYSLITPAGLPEERMHGGLMQLREQDLAPGLRRHRLRRRRRHGPRERRQ
                     RADGPGGRGGRRPAGPV"
     gene            complement(3542..4903)
                     /locus_tag="SAM23877_RS33575"
                     /old_locus_tag="SAM23877_7071"
     CDS             complement(3542..4903)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380623.1"
                     /locus_tag="SAM23877_RS33575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7071"
                     /product="APC family permease"
                     /protein_id="WP_053141391.1"
                     /transl_table=11
                     /translation="MSTAEPRTTDAADGGSPSLKRAIGPKLLILFVIGDILGTGIYATT
                     GKVAGKVGGALWLPFLIGFVVAFLTAASYVELVGKYPKAAGAALYTQKAFKVPFLTFIV
                     AFMVMCSGLSSASAAARAFSGDYFQEFTDAIPPTLIAIVFLLALSSLALRGVSESVKTN
                     VVLTVVELTGLLVILGIGAWAVFSGDGEPSRLGEFEGSGTGYALITGVLGATALGFFAF
                     VGFEDSVNMAEETQNPVRTFPRAIFTGVAVTGVIYVLVALVSSLLVDYRTLEASSGPLL
                     EVVKAGGVDFPPKLFALIALFAVTNSALINIMMASRLCYGLANERVLPRVMGKVLPRRR
                     TPITGIVFVTVLAIGLVSTGEIEGLGDTTSFLLLCVFAVVNVTVLVLRKDRVEHRHFRT
                     PTILPVLGALTALVLASPLADREADVYIRAGVLVAIGVALWGVNKLVMRLRPEG"
     gene            complement(5024..5701)
                     /locus_tag="SAM23877_RS33580"
                     /old_locus_tag="SAM23877_7072"
     CDS             complement(5024..5701)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAM23877_RS33580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAM23877_7072"
                     /product="hypothetical protein"
                     /protein_id="WP_159042031.1"
                     /transl_table=11
                     /translation="MTPGRVTYDVRYGVFPPAVVSSGGNEARGEAFRLCPDDPAPAPDR
                     YRSVHAFHVVPDTQGPSARVVTERPLGPRVSGHAAVYRVEDPSGTLLGRITMRRRRSFR
                     PGRTRWTVEPAAGPALRGYRGRLVWWALWWPVGLVVSLLWAITSLLGEGDGGFGPPRRV
                     IWRDGTGRAHLVFRGLADDYRVLTPGWDPRLVTALVALHQSFDPSDGAGALGWYQGGNR
                     RGL"
     gene            complement(5893..6378)
                     /locus_tag="SAM23877_RS33585"
                     /old_locus_tag="SAM23877_7073"
     CDS             complement(5893..6378)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SAM23877_RS33585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAM23877_7073"
                     /product="hypothetical protein"
                     /protein_id="WP_063796802.1"
                     /transl_table=11
                     /translation="MGHVESAHLVELALGNTSGDEDAGALRHIAACPFCREELTALTRL
                     VNAARDAQAVDLATAPPARLWQRISEEVTRESRTLPHPGRRSAAGAACGDRLTRPAGVT
                     GPGGLLAVALAAGAAAAAVAVRRWWTRTGQGRLRGPARQLHARTRTTPRTHPGRRRR"
     gene            complement(6418..7245)
                     /locus_tag="SAM23877_RS33590"
                     /old_locus_tag="SAM23877_7074"
     CDS             complement(6418..7245)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823977.1"
                     /locus_tag="SAM23877_RS33590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7074"
                     /product="DUF4397 domain-containing protein"
                     /protein_id="WP_053143122.1"
                     /transl_table=11
                     /translation="MTSRTPLAVAASAGACALALGVAAPAMAEPEQAQDKAMVSVFHGI
                     PGMTVDVYANGDELLSDFKPGTVTDPQSLDAGTYDIQIFQAGQGPDGAPALEKEVKVPE
                     GGNATLAAHLSANGEPQLTAYTDNVSQPDAGKARLTVRHVAAAPAVDVRAGGQPLFTGL
                     TNPGQDTATVDAGTVNTDVVLAGTDTVAIGPADVNLKEGTSNVVYAWGSAEDKNLALAT
                     QTFDSTGTKSPTSHAGTAVSPNSAAQWSAWAAAAGAVTLTGALVSRRVVGRRG"
     gene            complement(7352..7960)
                     /locus_tag="SAM23877_RS33595"
                     /old_locus_tag="SAM23877_7075"
     CDS             complement(7352..7960)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981393.1"
                     /locus_tag="SAM23877_RS33595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7075"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_053141395.1"
                     /transl_table=11
                     /translation="MSTNVRPATALVPPSEETRYEEDLARGLVAADEEAFAAIYRHWGS
                     LVHTMATRSLGDPHEAEDVTQQVFIGAWRGRQGFRPERGALGAWLVGITRRKIVDALAA
                     RTRRLTLVDSVARDCDPDRSLEPAPEAVLDRVLLVDALSRLPRAQREVLCMAFYEDLTQ
                     VQIAERTGVPLGTVKSHARRGLHRLRLAVDQGRTQDADR"
     misc_feature    8044..8062
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            8121..9128
                     /locus_tag="SAM23877_RS33600"
                     /old_locus_tag="SAM23877_7076"
     CDS             8121..9128
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157565.1"
                     /locus_tag="SAM23877_RS33600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7076"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_053141397.1"
                     /transl_table=11
                     /translation="MSVLVDGDDERDGRGGAEGGGLTTGEVARRLGVAPTTVRTWDRRY
                     GLGPEAHTGGRHRRWTPGDVARLERMCALTATGLPPAEAARLARREQTRAPAPRPPAGS
                     GGTGAPARGRSRAGSGLRLGDVRQECKGIARAALRLDAAALDELLLTSIAEHGLVAAWT
                     EVIVPTLQAVGRKWETSGEKYVEVEHFLSWHVSGALRRSTSATVADRPGATTLLACVPG
                     ENHTLPLEVLSAALTERGLPVRMFGGALPVESLVAAVRRTGPAAVGLWAQSRTTASRPL
                     AQHVAAMEWGVRGARRRPVVLTLGPGWTGQRAAGLARPAGLAEAVAAVESALSR"
     gene            10001..11215
                     /locus_tag="SAM23877_RS33605"
                     /old_locus_tag="SAM23877_7077"
     CDS             10001..11215
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566150.1"
                     /locus_tag="SAM23877_RS33605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7077"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_053141399.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1e-105, bitscore:
                     352.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSPDDTSDVVVLGGGAAGLSLAHRLTETGTASVTVVEPPDGPS
                     RPAERTWCYWDQDPGDLDDAVTKSWSVLRVHGADGRQVTVDPAPLTYRMVRSTSFERLV
                     HTRLARSPGGRLLRATADTVRDVPGGAEIRCTLPGGRPLTLRARRVFDSRPLRALPPAR
                     TQLLQHFRGWFVRTATERFDPAVADLMDFRVPQPAHGLAFGYVLPLTPDRALVEYTEFS
                     RTALTTQEYETALGHYCTDILGLGTLTVERTEQGAIPMTDARFPRRAGKAVFRIGTAGG
                     ATRPATGYTFAAVQRHSRAIAAALREGHGTVPAPHGRRALAMDAMLLRALDTGRIDGPD
                     FFTGLFRGVPAERLLRFLDGATSLGEEWRIGLRTPVRPMLRTAVELPFLPRRSRTDARN
                     GDNHR"
     gene            11212..11943
                     /locus_tag="SAM23877_RS33610"
                     /old_locus_tag="SAM23877_7078"
     CDS             11212..11943
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026914.1"
                     /locus_tag="SAM23877_RS33610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7078"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_053141401.1"
                     /transl_table=11
                     /translation="MSLLRDHDLARAFDHASHTYDRLTSLNPGYRTDLLRSARRLRLPG
                     EGAGLRVLDLGCGTGASTLALLRAAPRARITAVDASAGMLRRALAKPWPARVRFLHLTA
                     EEVATAGEGPFDAVFAAYLFRNVTDPDAVLGSVRTLLRPGGRLAVHEYSLSGSPTHRAL
                     WSAVCHGLLIPAGTLTGDRALYRHLRHSVTAFDTAPAFADRLGRAGFTGVRVAPVAGWQ
                     TGIVHTFLARNGSTTETEDTR"
     gene            11940..13511
                     /locus_tag="SAM23877_RS33615"
                     /old_locus_tag="SAM23877_7079"
     CDS             11940..13511
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843431.1"
                     /locus_tag="SAM23877_RS33615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7079"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_053141403.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-06, bitscore:
                     26.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.9e-14, bitscore: 52.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHRTGAARRGRDRKAEILTPPPGRDRFRRGDAPSVAVIGGGIA
                     GLAAATLLAERGARVTLYEKEDALGGRLSGGPTRLADGSPATMTRGFHAFFRQYYNLRG
                     LLRRTDPSLARLTPLPDYPLRHSGGLTDSFARVPRTPPFSALGFVALSPTFGWRDLAAM
                     DARAALPLLDVRVPEVYERFDEVTATGFLDSVRFPEAAHHLAFEVFSRSFFADPRELSA
                     AELLLMFHIYFLGSSEGLLFDVPSDPFPQALWDPLGDYLQRLGADIRTGTPVTDVVPLD
                     DGGAHVRTDADARRHQAVVLALDTRGLRRIVSESPRLGTSGWRAGIAALRTAPPFLVSR
                     LWLDRPVRTDRPGFLGTSGYDGLDNISVLERYEGEAARWAGRNGGSVVELHAYAVDTGA
                     EPKKVQDLLVDQLHRVYPETREARVVDARHEWRSDCPLFAVGSHRRRPTVRTPHPWLTL
                     AGDAIRCDLPVALMERAVTTGFLAANALLADRGVRGQVLWTVPRTGRSAALRALGAVAG
                     RGRGGR"
     gene            complement(13582..14724)
                     /locus_tag="SAM23877_RS33620"
                     /old_locus_tag="SAM23877_7080"
     CDS             complement(13582..14724)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837939.1"
                     /locus_tag="SAM23877_RS33620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7080"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_053141405.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.4e-49, bitscore:
                     166.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGPPTTAPAPAGAVDDPLTALAATDAVGSVLQEVLDARLRHSRA
                     VDPVFARDVADRVAALVARGGKRLRTAFACCGWRAAGGSGDPAAVLRVGAALELLQACA
                     LVHDDVMDGSLQRRGAPALHVELARGHWAAGMHGSAETFGTSAAVLAGDLALVWADDLL
                     TETALGTPHGPRLHEEWRAMRTEMVAGQYLDLHAQAARSSGVDEALTVATLKSALYTVA
                     RPLALGASLAGADEGTVEALRMAGRCAGLAFQLRDDLLGAFGDPALTGKPAGDDLRSRK
                     LTYLLAVAHRTADATADHQAAAVLAPDADTGSEYAVERIRAALERTGAREAVEAKIGEL
                     AAAGLRHFARADAPLAVRQEFAALVERASGVAPRRAQDER"
     gene            complement(<14883..15123)
                     /locus_tag="SAM23877_RS41545"
                     /pseudo=""
     CDS             complement(<14883..15123)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018471638.1"
                     /locus_tag="SAM23877_RS41545"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="cryptochrome/photolyase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHRLFGDQLGPPLPRPGRGGPRPRHARPRHRGPLGVPAAPLPPGR
                     GAPGAVRDAPPGGGARRTRHVRRRRHLPRGPGPGG"
     gene            complement(15137..16510)
                     /locus_tag="SAM23877_RS33630"
                     /old_locus_tag="SAM23877_7082"
     CDS             complement(15137..16510)
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524489.1"
                     /locus_tag="SAM23877_RS33630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7082"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_053141410.1"
                     /transl_table=11
                     /translation="MSVAVVLFTADLRLHDHPPLRAALRAADEVVPLFVLDPGIHAAGF
                     DAPNRRAFLADCLHDLDASLRRRAGRLVVRSGPVVRVVREVVAECGAGEVHLAAGVTAY
                     AHHREERLREGLGGSGVALHAHETVTTVVAPGAVTPAGSDHFAVFTPYFRRWARESLRE
                     PFGAPRTVRVPDGVRGGPLPDRAEVPGTSPGLPDGGETAGRDRFSLWSRAGMSAYEDRH
                     DDLAGDATSRLSPYLHFGALSAVELVHRARRRGGPGAEAFVRQLCWRDFHHQVLAARPK
                     ASAEDYRTRHDHWRGEKDAAADISAWREGRTGYPVVDAAMRQLRHEGWMHNRARLLVAS
                     FLTKTLYVDWRIGARHFLDLLVDGDIVNNQLNWQWVAGTGTDTRPHRVLNPVVQGRRFD
                     PDGAYVHRWVPELRDVDGKRVHEPWRLPEDQRAALDYPAPLIDLADGLDRFRHARGRD"
     gene            complement(16541..18070)
                     /locus_tag="SAM23877_RS33635"
                     /old_locus_tag="SAM23877_7083"
     CDS             complement(16541..18070)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923003.1"
                     /locus_tag="SAM23877_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7083"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_053141411.1"
                     /transl_table=11
                     /translation="METNGRRDVERLHSLVTGASGYIGGRLVPELLAAGHRVRCLARSP
                     GKLRDQPWAADVETVRGDVTDPQSVAEAMRGVDVAYYLVHALGSGADFEETDRRAASVF
                     ARQARAAGVRRIVYLGGLTPRNVPERSLSPHLRSRAEVGRIFLESEVPATVLRAAVVIG
                     SGSASFEMLRYLTERLPVMVTPSWVHTLTQPIGVRDVLRYLVGSATMPDDVDRAFDIGG
                     PDVLTYREMMRRYAVVAGLRRRVIVPVPVLTPRLSSHWVGLVTPVPASIARPLTESLRH
                     EVVCHEHDIARYVPDPPGRPLPFDEALGLALRKVREAQVATRWSSASYPGAPSDPLPTD
                     PDWAGGSLYTDERQLPVDASREALWKVVEGIGGDNGWYSFPLAWAVRGWLDRFVGGVGL
                     RRGRRDAERLRVGDSLDFWRVEEIEPGHLLRLRAEMRLPGLAWLEMYDETDDGGGTRYR
                     QRALFHPRGLFGHAYWWSVSPFHAVVFGGMARNITRAAARSRRRGRRRGRP"
     gene            complement(18177..19070)
                     /locus_tag="SAM23877_RS33640"
                     /old_locus_tag="SAM23877_7084"
     CDS             complement(18177..19070)
                     /NRPS_PKS="Domain: PKS_KR (11-187). E-value: 3e-18. Score:
                     58.3. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS33640_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152516.1"
                     /locus_tag="SAM23877_RS33640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7084"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_053141413.1"
                     /sec_met_domain="adh_short (E-value: 4.7e-32, bitscore:
                     110.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVARKPLHGRVAVVTGAARGLGAAMARVLVERGAKVALLGREER
                     TLALVRDSLPGTSDCWEVDVTDDRGMRLAGADIRARLGPPSVVVANAGVAEGGPFAESD
                     PQVWRRVVEVNLVGSAVTARSFLPDLFDTRGYFLQVASLASIGAAPMMSAYCASKAGVE
                     SFAHALRAEVAHRRVGVGIAYINWTDTDMVRDADEQAVLRELRGHMPPPARKVYPAAYV
                     AGRLVDAVERRRPSVYVPGWLRSTQLVRGAMPPVVTWLSRRELPRLAAAEPFSATGLLG
                     AGGRAGRRAGDEVPPG"
     aSDomain        complement(18510..19037)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS33640_PKS_KR.1"
                     /evalue="3.00E-18"
                     /label="SAM23877_RS33640_PKS_KR.1"
                     /locus_tag="SAM23877_RS33640"
                     /protein_end="187"
                     /protein_start="11"
                     /score="58.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGLGAAMARVLVERGAKVALLGREERTLALVRDSLPG
                     TSDCWEVDVTDDRGMRLAGADIRARLGPPSVVVANAGVAEGGPFAESDPQVWRRVVEVN
                     LVGSAVTARSFLPDLFDTRGYFLQVASLASIGAAPMMSAYCASKAGVESFAHALRAEVA
                     HRRVGVGIAYINW"
     CDS_motif       complement(18945..19031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAM23877_RS33640_0001"
                     /evalue="7.10E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="SAM23877_RS33640"
                     /protein_end="42"
                     /protein_start="13"
                     /score="21.9"
                     /tool="antismash"
                     /translation="VVTGAARGLGAAMARVLVERGAKVALLGR"
     gene            complement(19234..20124)
                     /locus_tag="SAM23877_RS33645"
                     /old_locus_tag="SAM23877_7085"
     CDS             complement(19234..20124)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852427.1"
                     /locus_tag="SAM23877_RS33645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7085"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_053141415.1"
                     /transl_table=11
                     /translation="MSESSPKDPLAEAFEAQRGRLRAVAHRVLGSHADAEDVVQEAWLR
                     LSRQDDPAAIRNLAGWLTTVVGRLSLDVLRSRQAHPQASYDDRLPELVVIADDGPAPED
                     DVALADSVGLALLVVLDSLGPSERLAFVLHDLFAVPFDEIGQILGRSTNAAKMLASRAR
                     GKVQATERPAAVGREQREVVEAFLAAARRGDFEGLLRVLDPDVRRTVETSDGVVVTLGA
                     TEVAAGARLSADAAVRGRAVLVNGRPGVMSWRADGSPLSVVAFTIAGGRITDITVVVDP
                     VRLAAAELPGPGVVH"
     gene            20207..20656
                     /locus_tag="SAM23877_RS33650"
                     /old_locus_tag="SAM23877_7086"
     CDS             20207..20656
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852426.1"
                     /locus_tag="SAM23877_RS33650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7086"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_053141417.1"
                     /transl_table=11
                     /translation="MEARMKSPANPDVITAIQHLMKAMHSGGVDPRLLDLVHLRASQIN
                     GCSPCVFAGVEGAKKHGETEERLHNVVAWRETPFYTDEERAALALTEAATRLQDGAPGV
                     TDEIWDAAADHFSEEQLSAIILDIAVTNFFNRINRTVRDQAGKTW"
     gene            20813..21664
                     /locus_tag="SAM23877_RS33655"
                     /old_locus_tag="SAM23877_7087"
     CDS             20813..21664
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321090.1"
                     /locus_tag="SAM23877_RS33655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7087"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_053141419.1"
                     /sec_met_domain="APH (E-value: 6.5e-19, bitscore: 67.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQGSQFSRAVAAARDTASSLGLEADDAVVLHDSNKLTLRLLPSDV
                     LARVAPVAQQVARFEVDLALRLAEAGCPVAALDPRVEPRVHERDGFVVTLWTHYEPVTP
                     REMPPADYAGALGRLHAGMRRLDVPTPHFTDRVEQARRLLTDRDRTPALADADRELLTR
                     TLSGLSRVAGESGGREQLLHGEPHPGNLLATEHGPLFIDFETCCRGPVEFDLAHAPDEV
                     GEHYPGADQELLRTCRLLVLAMITTWRWDRDDRFPDGHRLGTEWLGRIRAAVDGNGPDS
                     HN"
     misc_feature    20855..20870
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            21798..22364
                     /locus_tag="SAM23877_RS33660"
                     /old_locus_tag="SAM23877_7088"
     CDS             21798..22364
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827865.1"
                     /locus_tag="SAM23877_RS33660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7088"
                     /product="hypothetical protein"
                     /protein_id="WP_235614650.1"
                     /transl_table=11
                     /translation="MKSPTVPGGTSTAPKRRRHRTTGTRVRSVVTALALVAAPGAAVVG
                     SAGDAFAATKISHATATSMFRDVGITWSSSGNCSNRNNSTCTSFDQLNLATAQGAQTLK
                     RASGCALNITGGTETGHASGTYSHWNGYKLDFSKYTCVGNYIKNTFTYIGVRGDGAPQW
                     RSGSGNVYADEGNHWDVTYHNCGGC"
     gene            22505..23545
                     /locus_tag="SAM23877_RS33665"
                     /old_locus_tag="SAM23877_7089"
     CDS             22505..23545
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522978.1"
                     /locus_tag="SAM23877_RS33665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_7089"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053143126.1"
                     /transl_table=11
                     /translation="MLQVDFDEGALARLRVARGADPLWETVLSLHLLQTGQESLAYDGW
                     RREVRGALHRTGLADDVRALMPLCPPTGYFPDFLTPGRGDLDLEDGVDRVRSTPRRRLV
                     TELSRLCTDLRGPVPRSVRWVATGDATALRWLGSTLRRYHAVAVAPYLPAICARAGADR
                     ARRTEAVLGGGAEALLADYAELPGWRRQATRLAAPYPERRLLRLRGRPLTLVPGFFCVR
                     APLVLVDESLPLVLVHPLPPAPGWLPRLRAGTARPSVAQLIGASRARMLETLGTPMTTT
                     ALAAALSLAPSTASRHAAVLREAGLVAAHREGNRVLHRRTALGGALLDGAAPAAGAAPY
                     APRGAR"
     misc_feature    22544..22546
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23589..23603
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    24449..24463
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     misc_feature    complement(24516..24531)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
ORIGIN
        1 agtacgccgc gggccgcgcg gtgcgcccgg atcagagccc gggtcacgtc ggcgtccggt
       61 tccagggaac cggggtcgaa ggccgccgcg cccgagcgct cgccgccgcg ttcccgggtg
      121 cgggcggcct cgcgcatcag ggtgtgcatc agcgcgacca tgttgggctc gttgatcgtg
      181 accacatgac ggacccccgc cgcgaggatc tcggcggcca cgcccgcgta ggccgcgaac
      241 agtccggccg actcgggcga ggaccagccg ccgagttcac tgaaccaccg cggcgaggtg
      301 aagtggtgca gcgtcaccac cggagtcagc ccgcgcgcca gggccccgcg caccatgtcc
      361 cggtagtggg cgacggccgc ccgcgagatc cggccccgct cgggctccac acgggcccat
      421 tcgatcccga aacggtaggc gttgaagccg agttcgctca acaggtccat gtcctgcggc
      481 cagcggtgga agctgtcggc cgcgtcgccg ctcggctcgg cgacgaagct gtccggccgg
      541 ttctccaaca cccaccagtc gctggagacg ttgttcccct cgacctggtg ggcggaggtg
      601 gaggctccca tgaggaagcc gtgcggcagc acgagaccgg gcccggtcgg gggtgtcatg
      661 cggggctcct ttcgcctcgg agcccggccc ggagggaggc ggggccgagc tccgtgaaaa
      721 gcgttcattg atcggttttc gtgttagcgt acaggcggag ccgctccggc aggaaggcgc
      781 gccggccgcc ccccttccgg agcggcccgc cgcccggggc ccccggccca cctgactcgg
      841 ccgcgggccc ccggagccgg cggccacggc gaccgggccc gagccgcggc cccccgccaa
      901 cgggaccggc gcagtgccga caaccgcacc agccgcgtgg aggagaacca tggacgtcgt
      961 catcccgggc ccagcgaacc ggacggcagc cgccaccgga gaggcactgg gcctcgccgg
     1021 gccctggcgc gtcgccacca ccgaccaccg cctcaccgcg gtcgccggga cggttcgcgc
     1081 gctcctcgcc ccccacctgg gagaccgcct gctgcccccg gacacgaccg ggaccaccgc
     1141 caccaccctc gaactcgtcc tcgacgccgc ctcgtcggcc ccgcaccggg cccccgtcgg
     1201 catctcgccg cgcggcaccg cggaaccggg cgacgagtcg taccggatca cggtcgacga
     1261 acacggcgtc aggtgccggt ccaccacgcc cgagggcgtg ttccgcgccg ccaccacggc
     1321 gctccagacg ctcgccgcgg ccacgggccc cgtccctcgc ggggaactga cggacgcacc
     1381 gcactacgcg tggcgcggac tcatggtcga cccggcgcgc ggcttcctga cgcccgcgga
     1441 actgcgccgc gtcgtcgacc tcgcggccct gtacaaactg aacgtcctgc acctgcatct
     1501 gaccgacaac gagggctggc gcctgccgct gcccgccgcg gccgccaccg gcggaccgga
     1561 cgccgccgcg cggcagtact acattcccga cgactaccgc gccctgcagg cctacgcggc
     1621 cgagcgcttc gtcaccgtcg tccccgagat cgacctgccc ggccactgcg ccgctctgcg
     1681 cgaggcggtg cccggactgc ccgccgcccc ggcgccggaa gggctgaagg gccgcttccc
     1741 ctacgtgccg ccactcgacc tcgccgatcc cgacacccgg tccctggtgg cctccgtcct
     1801 caccgaggtg tgcgaactga ccgacggccc cttcgtgcac gtcggcggcg acgaggcggt
     1861 cggcatgacc gcggacagct tcgccctggc cgtacgtgaa ctacgcgccc tggtccgggc
     1921 ggccggcaag catccactgg cctggcagga ggcgtcacgc gccggcatga ccgcgaacga
     1981 catcgcccag ttctgggtgg acgtgccgat gatggacctg cccgacaccc aggaggaact
     2041 cgaccgccgc cccgaactgc tcgcggccgg ttacaccccc gagctggtcc gggccctcaa
     2101 gaggttcttc gccccgaccg acgacgacct cgcccggatc ctggacggcg gcggacgcgt
     2161 cctgctctcc ccgcagtccc acctctacct cgaccgccgc tacgctccgg acatcgtccc
     2221 gcccggtcag gccgaggacg ccgcccggct gggcttcgcc acctaccggc cccgcggggt
     2281 gcggcacacc gccgcctggg acccggccgc gtacgggatt cccgaggagc ggatcgccgg
     2341 catcgcggcg acggtcttcg gggagtcgat ccaggggctc gacgacctga ccaccctgct
     2401 gctgccgcgc ctgccgtccg tcgcccacac cgcgtggacc ggccgggccc cggactggga
     2461 cgcccaccgc gaccgtgtcg cccggcacgg caggctctgg gaggaccgcg ggctctccta
     2521 ccttgcctcc acggagatcc cctgggcgtg accccccgga cccggacgac gggcgggcgt
     2581 cggcacacgg tgtcacgctg gggtgaacag gaactgcgaa agggctccgc cgtgatcacc
     2641 actgacttcg tccccggctc cccctgttgg ctcgacctcg gcacccccga cgtccgcggc
     2701 gccgcggcct tctacggcgc cgtgttcggc tgggacttcg agtccatggg ggaggacgtc
     2761 gagggcggca tgttccgcaa ggacggcaag atcgtcgccg gtatcggccg gctcaccgag
     2821 gagggcgcgc gctccgcctg gatggtctac tactgcgtcg ccgacgcgga cgccacgacc
     2881 cgggccgtgc ggcaggcggg cggtacggtg cgcgtggcgc cgatggatct ggaccagtgg
     2941 ggccggatgg cccagtacag tgatccggcg ggcggtcagt tcgccgcgtg gcagccgggc
     3001 accagccagg gcgtcgagct ggtggaccag ccgggttcgc tgtgctggac ggagctgtac
     3061 acgagcgacg cggcggcggc caaggagttc tacggcactg tcttcggctg gcagttcggt
     3121 gacatggaga tgccggacgg tggcgggggc acgtactcgc tcatcactcc cgccggtctc
     3181 cccgaggagc gcatgcacgg cggtctcatg cagctccgcg agcaggacct cgcccccggt
     3241 cttcgccgtc accgactgcg acgccgccgt cgccacggtc ctcgagaacg gcggcagcgt
     3301 gcagatgggc ccggaggacg cggcgggcgt cggccggctg gccctgtgac tcgatccgtc
     3361 gaacgcggac ttcgtggtgc tcgcaccggc ccaggcgtga cgggacccgt ttcggaacgt
     3421 cgagccggtc gtgccgtgcc gtgccggcag ggccggccgg cgccgagccc gggacggcgc
     3481 gcccacgcgc ctgtccgttg tccccgggca ggtccccgac gcgttccggt ggcaggtcac
     3541 gtcacccctc cgggcgcagc cgcatgacca gcttgttcac gccccacagc gcgacgccga
     3601 tggcgaccag gacgccggcg cggatgtaga cgtccgcctc ccggtccgcg agggggctcg
     3661 ccaggaccag tgccgtgagt gctccgagga ccggcaggat cgtcggtgtg cggaagtgcc
     3721 ggtgctccac ccggtccttg cggaggacca ggacggtcac gttgaccacg gcgaacacgc
     3781 agagcaggag gaacgaggtg gtgtcgccga ggccctcgat ctcgccggtc gacaccagac
     3841 cgatggcgag gacggtgacg aagacgatgc cggtgatcgg cgtgcgccgg cgggggagca
     3901 ccttgcccat gacgcgcggc aggacccgtt cgttggccag gccgtagcag agccgtgagg
     3961 ccatcatgat gttgatcagc gcggagttgg tgacggcgaa gagcgctatc agggcgaaca
     4021 gcttgggcgg gaagtcgacg ccgcccgcct tgacgacctc cagcagcggg ccgctggacg
     4081 cctccagggt gcggtagtcc acgagcagcg acgacaccag cgccaccagg acgtagatga
     4141 cgcccgtcac ggcgacgccg gtgaagatcg cccgggggaa ggtgcggacc gggttctgcg
     4201 tctcctcggc catgttgacg gagtcctcga agccgacgaa ggcgaagaag ccgagcgccg
     4261 tggcgccgag cactccggtg atcagcgcgt atccggtacc cgatccctcg aactcaccca
     4321 gcctggacgg ctcgccgtca ccgctgaaca ccgcccaggc cccgatcccg aggatcacca
     4381 gcagtccggt caactcgacg accgtcagca ccacgttggt cttcaccgac tccgacacgc
     4441 cccgcaaggc gagggaggag agcgcgagga ggaacacgat cgcgatcagg gtcggcggga
     4501 tcgcgtcggt gaactcctgg aagtagtcgc cgctgaaggc gcgggccgcc gcgctggcgg
     4561 acgacaggcc cgagcacatc accatgaagg cgacgatgaa ggtcaggaac ggcaccttga
     4621 acgccttctg cgtgtacagc gcggcaccgg cggccttcgg gtacttgccg accagctcga
     4681 cgtacgaggc ggcggtgagg aacgcgacga cgaacccgat caggaacggc agccacagcg
     4741 caccgccgac cttgcccgcc accttgcccg tggtggcgta gataccggtc ccgaggatgt
     4801 caccgatgac gaagaggatc agcagcttgg ggccgatggc acgcttgagc gacggtgacc
     4861 cgccgtccgc tgcgtcggtg gtccgcggct cggctgtgct catgaggccc ctctcccgtt
     4921 ctccgtgcag aaggttctgc cctgcgggcc ggatgtgatg catgcaaccg gccgtcacac
     4981 ccggccgggc tccgacactt cgggagcgga ggagattcgg ccgtcagagg ccgcgtcggt
     5041 tcccgccctg ataccagccg agagcccccg cgccgtcgga ggggtcgaac gactggtgga
     5101 gtgcgaccag cgcggtgacc aggcgggggt cccagccggg ggtcagcacc cggtagtcgt
     5161 cggccaggcc gcggaagacg aggtgggccc gtccggtccc gtcgcgccag atcacacggc
     5221 gtggaggccc gaacccgccg tcaccctcgc cgaggaggga cgtgatcgcc cacagcaggc
     5281 tgaccaccag ccccaccggc caccacagtg cccaccacac caggcggcct cggtagccgc
     5341 gcagggcagg tccggcggcc ggctccacgg tccacctcgt ccggccgggc cggaaggagc
     5401 ggcgacgccg catcgtgatc ctcccgagca acgtgccgga cggatcctcg acacggtaga
     5461 cggcggcatg cccgctcacg cgtgggccga ggggccgttc ggtgaccacg cgcgccgacg
     5521 ggccctgcgt gtcggggacg acgtggaagg cgtggacgga gcggtaccgg tccggggcag
     5581 gggcggggtc gtcagggcag agccggaagg cctctcctcg ggcctcgttt ccgcccgaac
     5641 tgacgacggc gggcggaaac actccgtacc gcacgtcgta ggtcactcgc cctggagtca
     5701 tgctctacgt ctccctcaac ccgctcgacg gtccgctggg atgctctcat cccggtgcac
     5761 ggggggagcg gggaggttct cgcagtgcgg gcggtggtgc cggcggccgg tcggcgagcg
     5821 ggctgcggtg ggggacgcgg tgcacggagg tgcacacttc atcggggttt ccaggccgga
     5881 cgtccccgga cgtcagcggc gccgacgtcc ggggtgtgtc cggggggtgg tgcgcgtccg
     5941 ggcgtggagc tgtcgggcgg ggcctcgaag ccgtccctgg ccggtccttg tccaccaccg
     6001 tcggacggca acggccgcgg cggcggcgcc ggcggccagg gcgactgcca ggaggccgcc
     6061 gggccccgtg acgccggccg ggcgcgtgag ccggtcgccg catgccgccc cggcggcgga
     6121 gcgccgtccc ggatgcggga gcgtccggga ctcgcgtgtc acctcctcgg agatccgctg
     6181 ccagaggcgc gcggggggcg ccgtcgccag gtccaccgcc tgcgcgtcgc gcgcggcgtt
     6241 caccaggcgg gtcagcgccg tcagttcctc ccggcagaac gggcacgcgg cgatgtgccg
     6301 cagggcgccg gcgtcctcgt cgcccgacgt gttgccgagt gccagttcca ccaggtgcgc
     6361 cgactctacg tggcccactg cgtcctcctg gtccctcccg cgggccgacg cgtggtgtca
     6421 gccacgccgg cccacgacgc ggcgggagac cagggcgccg gtcagcgtga cggctcccgc
     6481 ggcggcggcc caagcggacc actgggcggc ggagttcggg gagacggcgg tccccgcgtg
     6541 ggaggtgggg gacttcgttc ccgtgctgtc gaacgtctgg gtggccagcg ccaggttctt
     6601 gtcctcggcg ctgccccagg cgtagacgac gttgctcgtt ccctccttca ggttcacgtc
     6661 ggcggggccg atcgcgacgg tgtcggtgcc ggcgaggacg acgtcggtgt tgacggtgcc
     6721 cgcgtcgacc gtcgcggtgt cctggccggg gttggtcagg ccggtgaaga gaggctgacc
     6781 accggcgcgt acgtccacgg cgggcgcggc cgcgacgtga cgcaccgtga ggcgcgcctt
     6841 gccggcgtcc ggctgcgaga cgttgtcggt gtaggccgtc agctgcggtt caccgttcgc
     6901 ggagaggtgt gcggcgagcg tggcgttgcc gccttcgggt accttcacct ctttctccag
     6961 ggccggtgcg ccgtcgggtc cctggcccgc ctggaagatc tggatgtcgt aggtcccggc
     7021 atccagggac tgcgggtcgg tcaccgtgcc gggcttgaag tcgctgagaa gttcgtcgcc
     7081 gttggcgtag acgtcgaccg tcatcccggg aatgccgtgg aagacggaga ccatggcctt
     7141 gtcctgcgcc tgctcgggtt ctgccatggc gggcgcggcc acaccgaggg ccagcgcgca
     7201 ggcaccggcc gaggcggcca cggcgagggg ggtccgggaa gtcatgggga tcatcccttc
     7261 gatacggtct ccgctgctgc ggagtctcag tcgtgtttcc tggacgagcg gtgccgcgga
     7321 tgcgtccgcg gccctgcttc cccccgatga cctagcggtc cgcgtcctgt gtgcggccct
     7381 ggtcgacggc caggcgcagc cggtgcagtc cgcggcgggc gtgactcttg accgtcccca
     7441 ggggcacacc cgtgcgttcc gcgatctgga cctgggtcag gtcctcgtag aaggccatgc
     7501 acagcacctc ccgctgggcg cgcggcagcc gggacagggc gtcgacgagg agcacgcggt
     7561 ccagtacggc ctccggtgcc ggctccagcg accgatcggg gtcgcagtcg cgggccaccg
     7621 agtcgacgag ggtcaggcgc ctcgtcctgg cggccagcgc gtcgacgatc ttgcggcgcg
     7681 tgatgccgac cagccacgca cccagcgcgc cgcgctccgg ccggaagccc tgccgtccgc
     7741 gccaggcacc gatgaacacc tgctgggtca cgtcctcggc ctcgtgcggg tcaccgaggg
     7801 accgggtggc catggtgtgg acgagtgaac cccagtgccg gtagatggcc gcgaacgcct
     7861 cttcgtccgc tgcgacgagg ccacgggcca gatcctcctc gtaccgggtc tcctccgagg
     7921 gcgggacgag cgcggtggcg ggtcgcacgt tcgtgctcat ggcctgattc ctcctgccgt
     7981 gcctcgtacg ggcacacaac gtcgtcccgc ggacggcgtg tacgccgtcc tgtcctgcgg
     8041 ggttgccgta cgtgactcca gtcttggacg cacgaacgac gcaggcaaca tgcgtcggtt
     8101 gtgcgtcgta cagtgaggtc atgagtgtcc ttgtggacgg tgacgacgaa cgggacggcc
     8161 ggggcggagc ggagggcggc gggctgacca ccggggaggt ggccaggcga ctgggcgtgg
     8221 cgcccaccac ggtccgcacc tgggaccgcc gctacggact cgggcccgag gcgcacaccg
     8281 gagggcggca ccgacgctgg acccccgggg acgtggcgcg gctggagcgg atgtgcgcgt
     8341 tgacggcgac cggactgccg cccgccgagg ccgcccggct ggcgcgccgc gaacagacgc
     8401 gggccccggc tccccgccct ccggcgggtt ccggcgggac cggcgccccg gcccgcggtc
     8461 gcagccgggc gggcagcggg ctgcggttgg gtgacgtgcg tcaggagtgc aaaggcatcg
     8521 cccgtgccgc cctgcgtctc gacgccgccg cgctggacga actgctgctc acctcgatcg
     8581 cggagcacgg actggtggcc gcctggaccg aggtgatcgt gccgacgctc caggccgtcg
     8641 gccgcaagtg ggagacgtcg ggcgagaagt acgtcgaggt cgagcacttc ctgtcctggc
     8701 acgtctccgg cgcgctgcgg cgcagcacgt ccgccacggt cgccgaccgc cccggcgcca
     8761 ccacgctgct cgcctgcgtg ccgggggaga accacacgct gccgctggaa gtgctgtcgg
     8821 ccgccctcac cgagcggggc ctcccggtgc gcatgttcgg cggtgccctg ccggtcgagt
     8881 ccctcgtcgc ggcggtgcgc aggaccgggc cggccgcggt ggggctgtgg gcgcagtcgc
     8941 gcaccaccgc cagcaggccg ctggcccagc acgtggccgc gatggagtgg ggggtgcgcg
     9001 gtgcccgccg caggccggtc gtcctgaccc tcggtcccgg ctggacgggg cagagggcgg
     9061 ccggtctggc gcgcccggcg ggactcgccg aggccgtcgc cgcggtggag tcggcgctgt
     9121 cacggtgacg cgtcctccgc ccggacggtg acgcgtcctc cgcccggacg gtgacgcgtc
     9181 ctccactcgg acggtgacgc gtcctccact cgggacggtg acgcgccgtc cgctcggaca
     9241 cggcgggcgg gcacccggta ccgggtagcc aggcgcctcg cctcgcagac gtcccgacac
     9301 gggcgggcgc cctgcggtac gggcctcccg ggtcacgggc tcctcgcggc gcgggctcct
     9361 cgcgacacgg gcgccgcgcg acacgggcgc cgcgcgagcc gggcaccgcg agagccggcc
     9421 atccgtgtca cgggtcgccc ggcgcgcccc ggcggcaacc gtggccgccg gaccacggga
     9481 cggttccccc gcccggccga tgccaggttg cgccgatgcc gggcgcgagg tgcctggcgc
     9541 ggacaccgcg ccggattccg cgccccttcc ggcgtccacg gcacagccga gccgtgcccc
     9601 cgcgcgaccg gaatcggacg gggccgccag gcgcgccgcg cggggagtac ccgccgccct
     9661 ggggtactgg tggcgtcggt aggtcagtcg aggtcgccgc atccagggac ggtcggcggc
     9721 cggaaagagg gatcgacggc gagcggtccg tcgaccccgg gctggagcga agcgtggaac
     9781 tgagcggcgc gtgtgtgccg gtgaccggtg ccggaggacc ggagccccgt gcccggcccc
     9841 tcggcacctg ctgcaccgac cgatccccgg cgggcgcggc cccgccgcgg gcgggcggcg
     9901 ccccgcgtcg gacggcggac cccgtcccgg gcgtaccggc agccgatgcc ggcctcccgc
     9961 gccccggccc ggaccgtacg cccgtcgaac ggcggacccg atgacctcct cgcccgacga
    10021 cacgtccgac gtggtcgtcc tcggtggcgg cgcggccgga ctcagcctcg cgcaccggct
    10081 gaccgagacc gggaccgcca gcgtgaccgt ggtcgagccg ccggacggcc cgtcgcgccc
    10141 ggcggagcgc acctggtgct actgggacca ggacccgggc gacctcgacg acgccgtcac
    10201 caagtcgtgg tccgtgctgc gcgtgcacgg cgccgacggc cggcaggtca ccgtcgaccc
    10261 ggcccccctg acgtaccgca tggtgcgctc cacgtcgttc gagcgactgg tccacacccg
    10321 gctggcccgt tcacccggcg ggcgcctcct gcgggcgacg gcggacacgg tgcgcgacgt
    10381 gcccggcggc gccgagatcc gctgcaccct ccccgggggg cgccccctga ccctgcgtgc
    10441 ccggcgtgtc ttcgactcac ggccgctgcg cgccctgccg ccggcccgga cacaactgct
    10501 gcagcacttc cgcggctggt tcgtacgcac cgccaccgaa cgcttcgatc ccgcggtcgc
    10561 cgacctgatg gacttccggg tgccccagcc ggcgcacggg ctcgccttcg gctacgtcct
    10621 gccgctgacc ccggaccggg cgctcgtgga gtacaccgag ttctcccgca ccgcgctcac
    10681 cacccaggag tacgagacgg cgctcggcca ctactgcacc gacatcctgg gcctgggcac
    10741 gctcaccgtg gagcggacgg agcagggcgc gatcccgatg accgacgccc gcttcccgcg
    10801 gcgggccggc aaggcggtct tccggatcgg caccgccggc ggcgccaccc gaccggccac
    10861 cggctacacc ttcgccgcgg tgcaacggca cagcagggcc atcgccgccg cgctgcgcga
    10921 ggggcacggg accgtccccg cgccccacgg gcggcgcgca ctggccatgg acgcgatgct
    10981 gctgcgcgcc ctggacaccg ggcggatcga cggcccggac ttcttcaccg gcctgttccg
    11041 cggcgtcccg gcggagcggc tgctgcgctt cctcgacggc gccacctcac tcggggagga
    11101 atggcgcatc gggctgcgca cccccgtccg cccgatgctc cgcacggcag tcgaactgcc
    11161 cttcctcccc cgccgctccc ggaccgacgc acgaaacgga gacaaccacc gatgagcctg
    11221 ctgcgcgacc acgacctggc ccgcgccttc gaccacgcct cccacaccta cgaccgcctc
    11281 acctcgctca atcccggcta ccgcaccgac ctcctgcgct cggcccgccg tctccggctc
    11341 cccggcgaag gggccgggct gcgcgtgctc gatctcggct gcggtaccgg cgcctccacc
    11401 ctcgccctgc tcagggccgc gccccgcgcc cggatcaccg ccgtggacgc gtcggcgggc
    11461 atgctgcgcc gcgcactggc caagccgtgg cccgcacgcg tgcgcttcct gcacctgacc
    11521 gcggaggagg tcgcgacggc cggcgaaggc cccttcgacg cggtcttcgc cgcctacctg
    11581 ttccggaacg tcaccgaccc ggacgcggtc ctcgggagcg tgcggaccct gctgcggccg
    11641 ggcggccggc tcgccgtcca cgagtacagc ctcagcggct caccgacgca ccgggccctg
    11701 tggtcggcgg tgtgccacgg cctcctcatc ccggcgggca cgctcaccgg cgaccgtgcc
    11761 ctctaccgcc acctgcggca cagtgtcacc gccttcgaca ccgcccccgc cttcgccgac
    11821 cggctggggc gagccggctt caccggagtc cgcgtcgccc cggtggccgg atggcagacg
    11881 ggcatcgtgc acaccttcct cgcccgcaac ggctcgacca cggaaacgga ggacacccgg
    11941 tgaccgccca ccgcaccggg gccgctcgac ggggccgtga ccgcaaggcc gagatcctga
    12001 cgcccccacc cggcagggac cgcttccggc gcggggacgc gccgtccgtc gcggtgatcg
    12061 gtggcgggat cgccggtctc gccgcggcca ccctgctggc cgagcgcggt gcccgcgtga
    12121 ccctgtacga gaaggaggac gcgctcggcg gccggctctc cggcgggccc accaggctgg
    12181 cggacggctc cccggcgacc atgacccgag ggttccacgc cttcttccgc cagtactaca
    12241 accttcgcgg tctgctccgg cgcaccgacc cgtccctcgc gcggctcacc ccgctgcccg
    12301 actaccccct gcggcacagc ggcggcctga cggacagctt cgcccgagtc ccgaggacac
    12361 cgccgttcag cgcgctcggc ttcgtcgccc tgagccccac gttcggctgg cgggacctgg
    12421 ccgccatgga cgcccgggcc gcgctgcccc tgctcgacgt gcgcgtgccg gaggtctacg
    12481 agcgtttcga cgaggtcacc gccaccgggt tcctggacag cgtgcgcttc ccggaagccg
    12541 cccaccacct ggcgttcgag gtgttctcgc gcagcttctt cgccgacccg cgggagctct
    12601 ccgccgccga actgctgctg atgttccaca tctacttcct cgggtcgtcc gagggcctgc
    12661 tcttcgacgt accgagcgac ccctttcccc aggcgctctg ggatccgctg ggcgactacc
    12721 tccagcgcct cggggcggac atccgcaccg gcacccccgt gaccgacgtg gtccccctcg
    12781 acgacggagg tgcgcacgtg cgcaccgacg cggacgcccg gcgccaccag gccgtggtgc
    12841 tcgccctcga cacccgcggc ctgcgccgga tcgtcagcga gtcaccccgt ctgggcacgt
    12901 ccggctggcg cgccggcatc gccgccctgc gcaccgcgcc gcccttcctc gtctcccggc
    12961 tctggctcga ccggccggtc cgcaccgacc gtcccggttt cctcggcacc agcggctacg
    13021 acggactgga caacatcagc gtcctggaac ggtacgaggg cgaggccgcc cgctgggccg
    13081 ggcggaacgg agggtcggtc gtggagctgc acgcctacgc cgtggacacc ggcgcggaac
    13141 cgaagaaggt gcaggacctg cttgtcgacc agctgcaccg ggtgtatccg gagacccgcg
    13201 aggcgcgcgt cgtcgacgcc cggcacgaat ggcgctcgga ctgcccgctc ttcgcggtcg
    13261 gctcccaccg gcgccgcccc accgtacgca ccccccaccc ctggctgacc ctggccggcg
    13321 acgcgatccg ctgcgacctg cccgtcgccc tcatggaacg cgccgtcacc accgggttcc
    13381 tggcggcgaa cgcgctgctc gccgaccggg gggtgcgggg ccaggtgctg tggacggtgc
    13441 cccggacggg acgctccgcc gcactgaggg ccctcggtgc cgtcgccgga cggggccggg
    13501 gcggccgctg accggaccgg ccccgcggca cgccgggaac gccgggaggc gccggggacg
    13561 gctgcccgcc ccggcgcctc ctcagcgctc gtcctgagcg cgacgcggtg ccacgcccga
    13621 cgcgcgttcg accagcgcgg cgaactcctg ccgtacggcc aggggagcgt cggcgcgtgc
    13681 gaagtgccgg aggccggcgg ccgccagctc accgatcttc gcctccaccg cctcccgggc
    13741 gccggtgcgc tccagcgccg cccgtatccg ctcgaccgcg tactccgacc cggtgtccgc
    13801 gtccggcgcg agtacggcgg cggcctggtg gtccgcggtg gcgtcggcgg tccggtgcgc
    13861 gacggccagg aggtaggtga gcttgcgcga ccgcaggtcg tcgccggccg gcttcccggt
    13921 cagcgccggg tcaccgaagg cgccgaggag gtcgtcgcgg agctggaacg ccagaccggc
    13981 gcaccggccg gccatgcgca gcgcctccac cgtgccctcg tcggctccgg cgagcgacgc
    14041 gcccagggcg aggggccggg cgaccgtgta cagcgcgctc ttcagggtgg cgacggtcag
    14101 ggcctcgtcg acaccggacg aacgggcggc ctgggcgtgc aggtccaggt actgccccgc
    14161 gaccatctcg gtgcgcatcg cccgccactc ctcgtgcagg cgcggaccgt gcggcgtccc
    14221 gagggccgtc tccgtcagca ggtcgtccgc ccacaccagc gccaggtcac cggcgagcac
    14281 ggcggcggag gtcccgaacg tctccgccga cccgtgcatg cccgcggccc agtgcccgcg
    14341 ggccaactcg acgtgcaggg ccggggcgcc cctgcgttgc agtgacccgt ccatcacgtc
    14401 gtcgtgcacg agggcgcagg cctggagcag ttcgagcgcg gctccgacgc gcagcaccgc
    14461 cgcggggtcg cccgaaccgc ccgccgcccg ccagccgcag caggcgaaag ccgtacgcag
    14521 ccgctttccg ccccgtgcga ccagcgcggc gacccggtcg gccacgtccc gggcgaagac
    14581 gggatcgacc gcgcgggagt gacgcagacg cgcgtcgaga acctcctgga ggacgctgcc
    14641 cacggcgtcc gtcgcagcga gcgcggtgag ggggtcgtcg acggccccgg cgggtgcggg
    14701 agccgtcgtc ggcggtccga gcatgcacaa ccccttctca cgtccggtca tctgtacgac
    14761 gatgcttccg ccgagtgccc tcgtgcggat gcgccgatac ctgtccggta cggcgcccgt
    14821 cccggccccg caccccggtg atccccggcg cgcgcctcac ggcggtgcac cggacgcccc
    14881 cgtgccgccc ggtccaggcc ctcgcggtag gtgtcggcgc cgacgtacgt gacgcgttcg
    14941 ccgagctccg ccgcccggtg gcgcatcgcg gacagcacca ggtgcgcctc ggcccggtgg
    15001 aagcggcgcc gccggaacac cgagcgggcc tcgatgacga ggacgggcgt gtcgcggccg
    15061 gggcccgcct cgtccggggc gaggaagtgg ggggccgagc tgatcgccga agagccggtg
    15121 caccaccgct gcctcctcag tcgcgcccgc gggcgtgccg gaaccggtcc agcccgtcgg
    15181 cgaggtcgat gagcggggcg gggtaatcga gcgcggcgcg ctgatcctcc gggagccgcc
    15241 agggctcgtg caccctcttc ccgtccacgt ccctcagttc gggcacccag cggtgcacgt
    15301 aggcgccgtc gggatcgaag cgcctgccct gcaccacggg gttgaggacg cggtggggcc
    15361 gggtgtcggt gccggtaccg gcgacccact gccagttgag ctgattgttg acgatgtcgc
    15421 cgtccacgag gaggtccagg aagtgccggg cgccgatccg ccagtccacg tacagcgtct
    15481 tggtcaggaa gctcgccacc agcaggcgcg cccggttgtg catccagccc tcgtgacgca
    15541 actggcgcat ggccgcgtcg acgacgggat accccgtgcg tccctcccgc cacgcggaga
    15601 tgtccgcggc ggcgtccttc tcgccccgcc agtggtcgtg gcgcgtccgg tagtcctccg
    15661 cggacgcctt cggccgcgcg gccagcacct ggtggtggaa gtcccgccag cacagctgac
    15721 gcacgaacgc ctccgctccg gggccgcccc gcctacgggc ccggtgcacg agctccaccg
    15781 ctgagagagc cccgaagtgg aggtacggcg acagcctcga ggtcgcgtcc cccgccaggt
    15841 cgtcgtgccg gtcctcgtag gcggacatcc cggcccgcga ccacagcgag aaccggtcac
    15901 gccccgccgt ctcccctccg tccggaagac ccggcgaggt gcccggtacc tccgcgcggt
    15961 cgggcagtgg gccgccgcgc acaccgtcgg ggacgcgcac ggtacgcggc gcgccgaagg
    16021 gctcccgcag cgactcccgg gcccagcggc ggaagtaggg ggtgaacacg gcgaagtggt
    16081 cggaaccggc cggcgtcacc gcaccggggg cgacgacggt cgtcacggtc tcgtgggcgt
    16141 gcagggccac gccgctgccg ccgagcccct cgcgcagccg ttcctcacgg tggtgcgcgt
    16201 aggcggtgac acccgcggcc agatgcacct cgccggcccc gcactcggcc acgacctcgc
    16261 ggaccacccg gacgaccggt cccgaacgga cgacgagccg cccggcgcga cggcgcagcg
    16321 aggcgtcgag gtcgtgcagg cagtcggcga ggaaggcccg ccggttgggg gcgtcgaagc
    16381 cggccgcgtg gatgccggga tccagcacga acagcggcac cacctcgtcc gccgccctga
    16441 gcgcggcgcg cagcggcgga tggtcgtgca gacgcaggtc cgcggtgaac aggacgaccg
    16501 cgacgctcat ggctggctcc tggtgcggtg gtgcggggcg ctacggtcgg ccacggcgtc
    16561 ggcctcgtcg tcggctgcgc gcggcggccc gggtgatgtt gcgggccatg ccgccgaaga
    16621 cgacggcatg gaagggggag acggaccacc agtaggcgtg gccgaagaga cctcgcgggt
    16681 ggaacagcgc gcgctgccgg taacgggtgc ctcctccgtc gtccgtctcg tcgtacatct
    16741 ccagccaggc cagtcccggc agccgcatct ccgcccgcag ccgcagcagg tgtcccggct
    16801 cgatctcctc gacgcgccag aagtccagcg agtcgccgac gcgcagccgc tcggcgtcac
    16861 gtcgtccgcg gcgcaggccg acgccgccga cgaaccggtc cagccagccg cggaccgccc
    16921 aggccaacgg gaaggagtac cagccgttgt cacccccgat gccctccacc accttccaca
    16981 gcgcttcccg ggacgcgtcc acgggcagct gccgctcgtc ggtgtagagg ctgcctccgg
    17041 cccagtcggg gtcggtgggc agggggtcgc tgggggcgcc cgggtaggaa gcggacgacc
    17101 agcgggtggc gacctgcgcc tcgcgcactt tccgcagggc caggcccagc gcttcgtcga
    17161 agggcagagg ccggcccggg ggatcgggga cgtagcgggc gatgtcgtgt tcgtggcaga
    17221 cgacctcgtg ccgcagggac tccgtgaggg gccgcgcgat ggaggccggc acgggggtca
    17281 cgagaccgac ccagtggctg gacagccgtg gggtgagcac ggggaccggc acgatgaccc
    17341 gtcgccggag cccggcgacg acggcgtagc ggcgcatcat ctcgcggtag gtgagcacgt
    17401 ccggtccgcc gatgtcgaag gcccggtcga cgtcgtccgg catggtggcc gacccgacca
    17461 ggtagcgcaa cacgtcgcgg accccgatgg gctgcgtgag ggtgtgcacc caactggggg
    17521 tgaccatgac cggcagccgc tcggtcagat agcgcagcat ctcgaacgag gcggatcccg
    17581 aaccgatgac gaccgcggcc cggagcacgg tggcgggcac ctcggactcg aggaagatcc
    17641 gccccacttc ggcgcgggag cgcagatggg gggagagcga ccgctcgggc acgttccgcg
    17701 gagtgagacc gcccaggtag acgatcctgc ggacaccggc cgcacgcgcc tgccgggcga
    17761 agaccgacgc cgcgcgacgg tcggtctcct cgaaatccgc gcccgaaccg agggcgtgca
    17821 ccaggtagta ggcgacgtcg acaccgcgca tggcctcggc caccgactgc gggtcggtga
    17881 cgtccccccg cacggtctcc acgtccgccg cccagggctg gtcgcgcagt ttgccggggg
    17941 agcgggccag gcaccggacc cggtgaccgg ctgccagcag ctccgggacc aggcgcccgc
    18001 cgatgtatcc ggacgcgccg gtcaccagag agtgcagccg ctccacgtcc cgccgtccgt
    18061 tcgtctccac ggcccgtcct ccggttcgtc ccagtccacc cggcacccct gcgtgctcag
    18121 cacctgttcg caccccgcgc ctgcggcgga tgcacgaggc gcgcgccgcc gtcccgtcat
    18181 ccgggcggga cctcgtcgcc cgccctccgt cccgcccggc cgccggcgcc gaggagcccc
    18241 gtcgccgaga acggctccgc ggcggcgagc cgcggcagct cgcgccgcga cagccaggtg
    18301 acgacgggcg gcatcgcgcc gcgtacgagc tgggtcgagc gcagccatcc cggtacgtag
    18361 accgacggcc ggcgtcgctc gacggcgtcg accagccggc ccgccacgta cgccgccggg
    18421 tacaccttgc gcgccggcgg cggcatgtgc ccgcgcagct cccgcagcac ggcttgctcg
    18481 tcggcgtcac gcaccatgtc ggtgtccgtc cagttgatgt aggcgatccc cacacccacg
    18541 cgccgatggg cgacctcggc gcgcagcgcg tgggcgaacg actcgactcc ggccttcgag
    18601 gcgcagtacg cgctcatcat cggagccgct ccgatggacg cgagggaggc cacctgcagg
    18661 aaatagcccc gcgtgtcgaa caggtcgggc aggaacgacc gggcggtgac ggcgctgccg
    18721 acgaggttca cctccacgac gcggcgccac acctgggggt ccgactcggc gaagggaccg
    18781 ccctcggcca caccggcgtt ggcgaccacc accgacggag ggccgagtcg cgcgcggatg
    18841 tcggcgcccg ccagcctcat gccccggtcg tcggtgacgt caacctccca gcagtcggag
    18901 gtgcccggca gcgagtccct gaccagcgcc agcgtcctct cctcacggcc cagcagcgcc
    18961 accttcgcgc cccgttcgac caggacccgg gccatggcgg cgccgagacc gcgcgcggct
    19021 ccggtcacga cggcgacgcg accgtgcaag ggcttccggg cgaccggcat ggaaggttcc
    19081 tttccgcggt ggctcctgcc cggcccacgc tagacgcgta cccgcgccgg ggcatgccgg
    19141 ccgctgctgg gcgggcggcc gtggcccggc gcggggcggc ggaccggccg tggccctggc
    19201 gggcgcgtca ccgctccggg accgccgagg ggctcagtga accacccccg gacccggcag
    19261 ctccgccgcc gcgagccgga ccgggtccac caccaccgtg atgtcggtga tgcggccgcc
    19321 ggcgatggtg aacgcgacga ccgagagcgg ggagccgtcc gcacgccagg acatgacacc
    19381 gggacgaccg ttgacgagca ccgccctccc ccgtacggcc gcgtcggccg acagccgtgc
    19441 gccggcggcg acctcggtgg cgccgagggt gacgaccacg ccgtcggagg tctcgacggt
    19501 ccgtcgcacg tcggggtcga gcacgcgcag caggccctcg aagtcgccgc ggcgggccgc
    19561 ggccaggaag gcctcgacca cttcccgctg ctccctgccg acggccgccg ggcgctccgt
    19621 cgcctgcacc ttgccgcggg cgcggctggc gagcatcttg gcggcgttgg tggatcggcc
    19681 gaggatctgg ccgatctcgt cgaacggcac ggcgaacagg tcgtgcagca cgaacgccag
    19741 ccgctcgctc ggcccgagcg agtccaggac gacgaggagg gcgagtccga ccgagtcggc
    19801 gagcgccacg tcgtcctccg gcgcggggcc gtcgtcggcg atgaccacca gctcgggcag
    19861 ccggtcgtcg taggacgcct gcgggtgggc ctggcgcgac cgcagcacgt cgagactgag
    19921 ccggccgacc accgtggtga gccagcccgc cagattgcgg atggccgccg ggtcgtcctg
    19981 gcgggagagc cgcagccacg cctcctggac gacgtcctcg gcgtcggcgt gcgagccgag
    20041 cacgcggtgg gcgaccgcgc gcagccggcc gcgctgggcc tcgaacgcct cggccagcgg
    20101 gtccttcggg ctgctctcgg acatgtcgtt accttcctcc ggtgcgctcc gtcatgtgga
    20161 tgacgtgccc ggacgggcac aggtaaccga cgagggagca ggactgatgg aagcacggat
    20221 gaagagcccg gcgaatccgg acgtgatcac ggcgattcag cacctcatga aggcgatgca
    20281 ctccggcggc gtcgatccgc gcctgctgga tctggtccac ctgcgcgcca gccagatcaa
    20341 cggttgcagc ccctgtgtct tcgccggtgt cgagggggcg aagaagcacg gagagaccga
    20401 ggagcggctg cacaacgtgg tcgcgtggcg ggagacgccc ttctacaccg acgaggagcg
    20461 ggcggcgctc gcgctgaccg aggcggccac ccggctccag gacggtgcgc cgggcgtgac
    20521 ggacgagatc tgggatgccg cggccgacca cttcagcgag gagcagctgt ccgcgatcat
    20581 cctggacatc gcggtgacca acttcttcaa ccggatcaac cgcacggtcc gggatcaggc
    20641 cggcaagacc tggtgagacg agcgggcggc acccgcccgg gccggcgccg gcgtccgctc
    20701 caccggacgc cggcggccgg cgctcgacga ccgccgccgg cgtccgggcg cgctccctcc
    20761 cgcggacggc attgctaggg tgcgctgacg acgagagggg ggcagggccg cgatgcaggg
    20821 gtctcagttc tcgcgggcgg tggcggcggc cagggacacg gcctcgtcac tcggcctgga
    20881 agccgacgac gcggtcgtgc tccacgactc gaacaagctc accctgcgtc tgctcccgag
    20941 cgacgtcctg gcccgggtgg cgcccgtggc ccagcaggtc gcgcgcttcg aggtcgacct
    21001 cgccctgcgg ctggccgaag ccgggtgccc ggtggcggca ctcgacccgc gggtggagcc
    21061 ccgcgtccac gaacgcgacg gtttcgtggt cacgctgtgg acccactacg agcccgtgac
    21121 accccgcgag atgccgccgg ccgactacgc cggtgcgctc ggccggttgc acgccggcat
    21181 gcggagactc gacgtcccga cgccgcactt cacggaccgg gtggagcagg cgcgacggct
    21241 cctgacggac cgcgaccgca cgcccgcgct cgccgacgcg gaccgggagc tgctcacccg
    21301 cacgctgagc ggcctgagcc gggtggccgg cgagagcggc ggccgcgagc agctgctgca
    21361 cggcgagccg cacccgggca acctcctcgc cacggagcac ggcccgctgt tcatcgactt
    21421 cgagacgtgc tgccgcgggc ccgtcgagtt cgacctcgcg cacgctcccg acgaggtcgg
    21481 cgagcactac ccgggagcgg accaggagtt gctgcgcacg tgccggctgc tcgtcctggc
    21541 gatgatcacg acgtggcgct gggaccggga cgaccggttc cccgacgggc accggctggg
    21601 caccgagtgg ctcggccgga tccgagcggc ggtcgacggc aacggcccgg actcccacaa
    21661 ctgagcgccg gccgaagggg attggttcgc cacgtcccga cgcactctgg cgtacgcgcg
    21721 tagacctcgg gcaccatcgt cgtgcaccgc atgctcaacc accccacagg cggcatgacg
    21781 tactgcatgg aggtccgatg aagtctccga ccgtccccgg cggcacctcg acggcaccga
    21841 agagaaggcg gcaccgcacg accggcacgc gcgtccggtc ggtggtcacg gccctcgcgc
    21901 tggtggccgc accgggcgcc gccgtcgtcg gcagtgccgg cgacgccttc gcggccacca
    21961 agatcagcca cgccaccgcg acgtcgatgt tccgcgacgt cggcatcacc tggtcgtcct
    22021 ccggcaactg ctccaaccgg aacaactcga cctgcacctc cttcgaccag ctcaacctcg
    22081 ccaccgctca gggcgcccag accctcaaac gggccagcgg atgcgcgctg aacatcacgg
    22141 gcggaaccga gacgggacac gcctccggca cctactcgca ctggaacggc tacaagctgg
    22201 acttcagcaa gtacacgtgc gtcggcaact acatcaagaa caccttcacc tacatcggcg
    22261 tccgcggtga cggcgctccg cagtggcgat ccggctccgg caacgtgtac gccgacgagg
    22321 gcaaccactg ggacgtgacg taccacaact gcggcggctg ctgaggcgcc accgcggtcg
    22381 gcgacacggg atcgggacac gtgcgcgacg cccacccggg cccggcgcgt gtcccgaggg
    22441 ccgttcacgg ctgacgggcg gagtgcgcga cgactccgcc ccctcgggag tggagtggta
    22501 cggagtgctt caggtcgact tcgacgaagg cgcgttggcc cggttacggg tggcgcgagg
    22561 tgccgacccc ctgtgggaga cggtactgag ccttcatctc ctgcagaccg gacaggagtc
    22621 cctggcctac gacggctggc ggcgcgaggt gcgcggcgcg ttgcaccgca cgggactcgc
    22681 cgacgacgtg cgggcgctga tgccgctgtg cccgcccacc gggtacttcc cggacttcct
    22741 cacgcccggc cgcggcgacc tcgacctgga ggacggcgtg gaccgtgtgc ggtcgacgcc
    22801 ccggcgcagg ctcgtcaccg aactgagccg gctctgcacg gacctgcgag gtccggtgcc
    22861 gcgcagcgtg cgctgggtgg ccacgggcga cgcgaccgcg ctgcgctggc tcggcagcac
    22921 cctgcggcgg taccacgcgg tggccgtggc accgtacctg ccggcgatct gcgcccgggc
    22981 gggggcggac cgcgcccgtc gtaccgaggc ggtcctcggc ggcggcgcgg aggccctgct
    23041 cgccgactac gcggaactgc ccggctggcg gcggcaggcc acccggctcg cggcgcccta
    23101 ccccgagcgt cggctgctgc ggctgcgcgg acgcccgttg acgctggtac ccggcttctt
    23161 ctgcgtacgg gctcccctgg tcctcgtgga cgagtcgctg ccgttggtgc tggtgcaccc
    23221 gctgcccccg gcgccgggct ggcttccccg gctgcgcgcg ggcacggccc ggccgtccgt
    23281 cgcgcagttg atcggtgcct cgcgggcccg gatgctggag acgctgggca cgccgatgac
    23341 gacgacggcg ctggcggcgg cgctgagcct ggcgccctcc acggcgagcc ggcacgccgc
    23401 ggtgctgcgc gaggccggac tggtggccgc gcaccgggag ggcaaccggg tgctgcaccg
    23461 tcgcaccgcg ctgggcggcg cactgctgga cggggcggcc cctgcggcgg gcgccgcccc
    23521 gtacgcgccg cgcggcgccc gctgaggcgc tcgcggggtc agcaggtggg cacgcccggg
    23581 agccaggcgt cagcgacgtc gatgaagatg ttggagacgt agccgccgta gtcgggcagg
    23641 tacgaccacg cgtcgttgct gtagccgtcg tggttcacca gctgaccgtg gacctggcat
    23701 ctcacccgca cggtcgtggg accgggcagg ttcgccacgc gggtcgatgc ggtcgtcgcc
    23761 tgctgccgga cgcccacgtc ggtgccccac gtcgggaagg acgtggtgtc gcccccgctg
    23821 tccgtccaca gataggtgac ggtcacccag ccgttgtcgt cgaggcccac gttgtagaag
    23881 gtgccgtcgg ccaggtcgat gcccgccggg ttggcgacct gccggccgaa ctcgtcgcgt
    23941 ccgccgttgt aaccgtcctc gtaggcggcc tgggcctcgg gcaggccccg tggcaggtcc
    24001 ttccactgct cgcgctgcgc cgacgggttc cagtggtcgt cgtgcgtgtt ccaggggccg
    24061 acgtcccaca cgggcgccgt ctcgcagcgg accggaccgc acacctgcac cgagtactgg
    24121 ccgctgccgg ccggagacag cgcacggcgc gagggcagtg ccacgaagtg gtcgttctcg
    24181 cggatgacgt ggccgttggc ggtggtgtgc ccgaccagac cctcgcgggt ggcgtagacc
    24241 cgggccgaga aggcggaggc cgccgtcatc ccgggtccgg cggggacgct gcccgtgtcg
    24301 tccgccgtca gcgtcagtcc cctcacggcg gcggtggccc cgccctcggc gttccacagg
    24361 gtgagccggg cctggacgtc gacgacacgg cgcggcagtt gcgtcggggc gccggtcgcc
    24421 gcgctccgcc actcggtcca cgctccgtcg gccgaccggc cccgcacgtc gacctcggcg
    24481 ctcgccgccg cgggcaccgt cgcgtcgagg gccaccgtga cccggttcac cggccggtcc
    24541 acgcggtgcg ccgccagcac ggcggaggcg tacccgccgt cgcggtccag ggaggcgggg
    24601 ctgacggaac cgtcacgcac ccgcagggcg ccctcccggt actggacgtt gacgtcgtcg
    24661 gtgccggtcc gggacaggtc cggctgccag gacaccgggg cgggcgacga ggtctcggcg
    24721 gccg
//
