LOCUS       NZ_CP012382            22901 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7480529
            Orig. end                         :: 7503430
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22901
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="25"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..22901
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22901
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12901](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12901
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(62..77)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.21"
                     /tool="antismash"
     misc_feature    508..521
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(626..1534)
                     /locus_tag="SAM23877_RS32955"
                     /old_locus_tag="SAM23877_6942"
     CDS             complement(626..1534)
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039369.1"
                     /locus_tag="SAM23877_RS32955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6942"
                     /product="Ku protein"
                     /protein_id="WP_053141182.1"
                     /transl_table=11
                     /translation="MPRTIWSGAISFGLVTVPIDVVSATEDHSIHFHRVHLDDMARVRT
                     RKVCELEDREVSSSEIGKGYELSRTQVIPISDEELRDLPLPTAKAIEIVAFMPWESVDP
                     LRIAEGYYLAPDGQVAAKPYKLLRQALERSSRVAVARYAWSGRERLGLLRVREEAIVLH
                     AMRWPDEIRDPSSLTPPPVELTDEEIDGALALMDTMTRDGLEGEEFRDTYTEAVAELIE
                     AKREHREPPAAKEEPAAESGQLVDLMAALQESVSKAKATRGEDTGGHADVHEMPKKRTA
                     KKGPAKKTAAKKTARKPRRSA"
     gene            complement(1670..2905)
                     /locus_tag="SAM23877_RS32960"
                     /old_locus_tag="SAM23877_6943"
     CDS             complement(1670..2905)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039343.1"
                     /locus_tag="SAM23877_RS32960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6943"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_079030578.1"
                     /transl_table=11
                     /translation="MSSGPIELPRLLTAAETAAPVDAVDVVAEHLRRRFEAREISFLIV
                     DLTGKAVARLPTSDVPGGREAQRIPLFGSVYEQVIRTQRLYQEATDQGQRMIVPVTNRG
                     DAIGLLELMLPAVPDEGVLEAVGEAAHVLGYLVIANGRFTDLYNWGKRSRPPTLAAEIQ
                     YQLLPPSLSCEAAQFALCGNLEPSGNLSGDTFDYAVDRDTLHVSVTDPMGHDIAAALAA
                     TVLVSALRGARRAGASLTDQAHRADRALADHDHGHATGQLLRVDLHTGVAQLVNAGHPW
                     PLRMRDGTVDVIACAVDPPFGLSVIEPHSYRAQNIDLRPGDRLLMLTDGMLERHGEDID
                     LPALLRRTRSLHPRETTLMLTSAIRDAAGGRLEDDATVMCLDWHGTQETQRHVSSGADT
                     RQASAGRPKQER"
     misc_feature    3018..3031
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(3021..3034)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.31"
                     /tool="antismash"
     gene            3101..3571
                     /locus_tag="SAM23877_RS32965"
                     /old_locus_tag="SAM23877_6944"
     CDS             3101..3571
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010472717.1"
                     /locus_tag="SAM23877_RS32965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6944"
                     /product="DIP1984 family protein"
                     /protein_id="WP_053143096.1"
                     /transl_table=11
                     /translation="MKLAEALAERAEATRRVDQLRARVVDSARYQEGETPAEDAAQLLA
                     EAGEVLDTLETLIRRINRTNAAVEVGPDGTLTDALARRDVLRLRHSVVTAAADAAAGKG
                     ERGYGRQLRSELLMLSALPVAELRGQADALAREIREIDVRIQRANWEVDLLD"
     gene            complement(3883..5016)
                     /locus_tag="SAM23877_RS32970"
                     /old_locus_tag="SAM23877_6945"
     CDS             complement(3883..5016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824007.1"
                     /locus_tag="SAM23877_RS32970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6945"
                     /product="hypothetical protein"
                     /protein_id="WP_174532271.1"
                     /transl_table=11
                     /translation="MRVSSQGITVVALLADPDAPTEIAQRMARALPDRLAERSGQGRRF
                     HVEVVSEPFTAGTEDPPTLMRRISDRAGAETWDVVVALTDLPLHSHGRELVVELSHAHG
                     SALLSLPPLGGLRLQRRARRAVEEAVLSLVGPRATGNGGTPRDQPPAGSFVGRLAPVRP
                     GPVGEEESVDLRYVAGGPRGHLRVLLGMVRANRPWRLLSGLSKALAAALATGAIATVNS
                     TIWSLASSLSVPRLVIAMVGSVALMLGWLIVDAHLWHRSAEGTPEARRRAALYNASTVV
                     TVGIGVLVCYVGLMVINLVWALFILNDQVFASMTRTPLQATEYWTLSWFVASVATVGGA
                     LGSSLESDEAIRAAAYSKREQERRHMLQDDHADQLPK"
     gene            5242..5964
                     /locus_tag="SAM23877_RS32975"
                     /old_locus_tag="SAM23877_6946"
     CDS             5242..5964
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978269.1"
                     /locus_tag="SAM23877_RS32975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6946"
                     /product="FAD binding domain-containing protein"
                     /protein_id="WP_053143100.1"
                     /transl_table=11
                     /translation="MLVRLPTSVSEAQECMAQGAVPIGGATLVWATWQRDGFPELAMSL
                     RDLPEASVVEPEALGAAVVLHRIDARVPEVLRRAAGTVGTGAVRRTATVGGNLVGSSLR
                     CLLPAALVLDARATVLGPDRAYETDLPEVVAKRHLLLGLRWRTPLASGYRKEPAEAGGP
                     PPLVVATAVHAVDGGPRQLRVAVRDGYEVLSGTVSCDAGADGAFDLLRRSDVGALPPGA
                     RDVVREQVADILDSLTER"
     gene            complement(5989..6828)
                     /locus_tag="SAM23877_RS32980"
                     /old_locus_tag="SAM23877_6947"
     CDS             complement(5989..6828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027227.1"
                     /locus_tag="SAM23877_RS32980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6947"
                     /product="lysozyme"
                     /protein_id="WP_053143101.1"
                     /transl_table=11
                     /translation="MRRPIAVAPSHSRRLLTSGVLLAVPSLLLTLPAAPASADGTGATP
                     VRGSAHMGMGVLAHEGVQGQPADTRVTQTEGVDVSSHQGNVAWPTLWSSGVKWAYVKAT
                     EGTSYRNPYYAQQYGGSYDVGMIRGAYHFATPDGAGGAAQADYFVDHGGGWSKDGRTLP
                     GVLDIEYNPYGDTCYGRTASQMVAWIGDFLDRYKARTGRDAAIYTSTNWWKQCTGDYSG
                     FGSTNPLWIARYASTVGPLPAGWDFHTMWQYTSTGPTVGDHDKFNGALDQVKALANG"
     gene            6992..7936
                     /locus_tag="SAM23877_RS32985"
                     /old_locus_tag="SAM23877_6948"
     CDS             6992..7936
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125777.1"
                     /locus_tag="SAM23877_RS32985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6948"
                     /product="TIGR01777 family oxidoreductase"
                     /protein_id="WP_053141184.1"
                     /transl_table=11
                     /translation="MKIVIPGGTGQVGTVLGRAWTAAGHEVVVLSRRPEQRGEVPWDGR
                     TPGDWFKEIDGSDMVVNLAGRSVNCRYTPTNLRAMMDSRVHSARVVGEAIAAVAEPPRV
                     WLQMSTATVYAHRFDAPHDEATGVVGGREADVPAYWSYSVEIAKAWERELERADTPHTR
                     KVALRSAMVMSPDRGGVLDVLLRLARLGLGGPVAGGAQYVSWIHERDFVRAVEFLAGRE
                     DLTGPVNLAAPSPLPQRAFMRALRQARGVPVGLPATRWMAELGALVLRSDTELLLKSRR
                     VVPGRLLEAGFTFDHPDWPEAAEDLVGRVRGSR"
     gene            complement(8036..9262)
                     /locus_tag="SAM23877_RS32990"
                     /old_locus_tag="SAM23877_6949"
     CDS             complement(8036..9262)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982175.1"
                     /locus_tag="SAM23877_RS32990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6949"
                     /product="cytochrome P450"
                     /protein_id="WP_053141186.1"
                     /sec_met_domain="p450 (E-value: 1.5e-26, bitscore: 91.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAAQQVPDILSAEFAANPYPAYRAMREGAPLFWHEATRSWIVSR
                     YEDVERVFKDRDGQFTTENYDWQIEPVHGRTILQLSGREHAVRRALVAPAFRGTDLQER
                     FLPVIERNSRELIDAFRYTGRADLVSDYATRFPVNVIADMLGLDKADHDRFHGWYTSVI
                     AFLGNLAGDPEIAAAGARTRVEFAEYMFPVIQERRENPGDDLLSTLCAAEVDGVRMSDE
                     DIKAFCSLLLAAGGETTDKAIASIFANLLAHPDQLAAVREDRTLIARAFAETLRHTPPV
                     HMIMRQSATEVELSGGTVPAGATVTCLIGSANRDESRYHDPDRFDILRDDLTTTTAFSA
                     AADHVAFALGRHFCVGALLAKAEVEIGVGQLLDAMPDLTPADGFDAVERGVFTRGPQSL
                     PVRFTPRAD"
     gene            9465..9629
                     /gene="rpmG"
                     /locus_tag="SAM23877_RS32995"
                     /old_locus_tag="SAM23877_6950"
     CDS             9465..9629
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005063154.1"
                     /locus_tag="SAM23877_RS32995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6950"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_053141188.1"
                     /transl_table=11
                     /translation="MARSTARPVVKLRSTAGTGVTYVTRKNRLNDPDRLVLRKYDPVAG
                     EHVPFREER"
     gene            9665..9787
                     /gene="ykgO"
                     /locus_tag="SAM23877_RS33000"
     CDS             9665..9787
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="ykgO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046794.1"
                     /locus_tag="SAM23877_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type B 50S ribosomal protein L36"
                     /protein_id="WP_053141190.1"
                     /transl_table=11
                     /translation="MKVRKSLRALKARPGAQVVRRRGVTYVINRRDPRFKARQG"
     gene            10001..11074
                     /locus_tag="SAM23877_RS33005"
                     /old_locus_tag="SAM23877_6951"
     CDS             10001..11074
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389575.1"
                     /locus_tag="SAM23877_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6951"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_053141192.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-40, bitscore:
                     138.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQPLDRAARCARRFDVLFAEYFETLSATLEAPSFSRFTPECLE
                     LLRDLSLRGGKRMRVVLLHEAARLVRDEPVDGLDAAALSIELLQTHGLVHDDLIDDSAT
                     RRGGPTTYHAYRERFPRHPQAALGLTVLAGDLALALSLRVLLDAELPVEVRQAMVEVQT
                     RAATDTFVGQIADLERDFAPAVPDDDVLHDVADHKSARYSVLAPLYLGLLAAGEQPAAF
                     EEELRRYARLVGICGQMRDDYLDLFGDAAAMGKPTGTDLREGRRSYTVARLLSAVSGAE
                     RVLVEGALGDRACTPETVAAVREIGERRGVASRMRADMRRYAEQAGQVAAGWRPRWRED
                     AVGFFERLPMWSVERAG"
     gene            11217..11408
                     /locus_tag="SAM23877_RS33010"
                     /old_locus_tag="SAM23877_6952"
     CDS             11217..11408
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126944.1"
                     /locus_tag="SAM23877_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6952"
                     /product="hypothetical protein"
                     /protein_id="WP_053141194.1"
                     /transl_table=11
                     /translation="MAVLFLSGILVLVLAGCACVVWAARGGPRWVRAVSAVTLAAGELV
                     RGAKGSGRSAGGRSAADD"
     gene            11566..11850
                     /locus_tag="SAM23877_RS33015"
                     /old_locus_tag="SAM23877_6953"
     CDS             11566..11850
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330752.1"
                     /locus_tag="SAM23877_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6953"
                     /product="hypothetical protein"
                     /protein_id="WP_053141196.1"
                     /transl_table=11
                     /translation="MAHATRRGRGRDDQAVLVVAGLADLAVSTLGSAVGAVRGLLRRSD
                     TADLVREAEQDLQARGRLALERCTNVPPAHLEVLAQHVRVRRAADGVDD"
     gene            11843..12901
                     /locus_tag="SAM23877_RS33020"
                     /old_locus_tag="SAM23877_6954"
     CDS             11843..12901
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978297.1"
                     /locus_tag="SAM23877_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6954"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_053141198.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.2e-39, bitscore:
                     132.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRWDPAAFKVRVDGVLRSYVDEEAGHLVAVDDALAPVAEQLRG
                     AAGHGKRLRAAFCYWGWRAAGQPDDDALVRAAAAMELVHAAAIVHDDLIDDSPLRHGLP
                     TAHVALEAVLARDGRRRPRAAARSLAMLVGDHLMALAGQLFAGSGLPAAYLARARGLWA
                     ELARELVAGECLEILHTGGRPDTGTSLKVVRYKTAKYTVEHPLLIGGLLAGAGPGLREA
                     YSAYGLPLGEAFQLRDDLLGLFGDPERTGKAGLDDLRTHRPTALLAETWEAADASQRER
                     LRGVLGRSDLDETHLREVRALMRELKAPQRVERMIGARVERATRALDSADTPPHARRVL
                     YALAQQATDRIH"
     gene            12915..14075
                     /locus_tag="SAM23877_RS33025"
                     /old_locus_tag="SAM23877_6955"
     CDS             12915..14075
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978298.1"
                     /locus_tag="SAM23877_RS33025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6955"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_053141200.1"
                     /transl_table=11
                     /translation="MTYTETSMDALRRSGDDLADAVVATLFERGEVGKFNSLMRYVSTA
                     GQALPDGLPGVAREYLRVTGAPPDWVDWSEMERARLFFIDNNVHISTALSFASMPACYV
                     VPHVARLLSATHGLSYPSKRMAETGQFTVYLMQPDAFEAGGRFIPAAQKVRLLHAAIRH
                     HLKREDRWDTDALGVPICQEDMIGGQMFFSLLVLDSLHRLGIHMSAEGADAYFYAWRVV
                     GAMLGVDQTAVPGTLDEARQFLDLYMLRHMGPSEEGAHLTRQLIDLYEEVVPGTLFDPV
                     VSALIRYLVGDTCADWLEVPRTTWDTLVKATPHLLGVLETIEDRSPLGAWALDRIGHLT
                     TVLELSSLTRGRVMHYAVPEQLRKDYGLSGAAARTRRWTPPPATVS"
     gene            complement(14117..14539)
                     /locus_tag="SAM23877_RS33030"
                     /old_locus_tag="SAM23877_6956"
     CDS             complement(14117..14539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330749.1"
                     /locus_tag="SAM23877_RS33030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6956"
                     /product="DUF350 domain-containing protein"
                     /protein_id="WP_053141202.1"
                     /transl_table=11
                     /translation="MSDIVNGLGRAAAYGGLGLVLLVLGIVLVDVLTPGKLGRQIWEQR
                     NRNAAMVLSSALLGIGGIVFTSIWTTYEDFGKGLVSTAAFGLLGLVMMALAFLVVDLIT
                     PGRLGATLVEPEPHPAVWVTASCNLAVSAVISASIA"
     misc_feature    complement(14602..14617)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.85"
                     /tool="antismash"
     gene            complement(14667..15767)
                     /locus_tag="SAM23877_RS33035"
                     /old_locus_tag="SAM23877_6957"
     CDS             complement(14667..15767)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978300.1"
                     /locus_tag="SAM23877_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6957"
                     /product="DUF475 domain-containing protein"
                     /protein_id="WP_053141204.1"
                     /transl_table=11
                     /translation="MLVKTFRWAFAVTALGLAAGVLYEGWTAFGLVAILAVLEVSLSFD
                     NAVINAGILKKMSAFWQKIFLTVGIVIAVFGMRLVFPVVIVAVSARLSPWSAVHLALTD
                     KERYQELVTDAHPSIAAFGGMFLLMIFLDFVLEDREIKWLGPLERALAKLGKVDMLSVC
                     VALIVLLVSAITFGAHAHQHGGIHADKAETVLLAGIGGLITYMVVGGLSGFFEDRLERE
                     EERERDAETAAARSGGNRSAVALTGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVL
                     MALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALAVILLVTIEYEINEVVT
                     GLIGVVLIGASFWSSVRRNRALAAGS"
     misc_feature    15895..15910
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            15969..16415
                     /locus_tag="SAM23877_RS33040"
                     /old_locus_tag="SAM23877_6959"
     CDS             15969..16415
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978301.1"
                     /locus_tag="SAM23877_RS33040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6959"
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_053141206.1"
                     /transl_table=11
                     /translation="MTASPDTAVASELRGAGLRVTAARVALLETVRRGGHLDAEAIAAG
                     VRRRVGHVSLQAVYEALHALTAAGLVRRIQPPGGPARFEGRVGDNHHHVLCRSCGALAD
                     VDCAVGEAPCLTASDDHGFAIDEAEVIYRGLCPDCSTPGSTPAP"
     gene            16439..18655
                     /gene="katG"
                     /locus_tag="SAM23877_RS33045"
                     /old_locus_tag="SAM23877_6960"
     CDS             16439..18655
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676808.1"
                     /locus_tag="SAM23877_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6960"
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_053141208.1"
                     /transl_table=11
                     /translation="MSENHDAIVTDAKTEEAGGCPVAHGRAPHPTQGGGNRQWWPERLN
                     LKILAKNPAVANPLGDGFDYAEAFGSLDLPAVKRDIAEVLTTSQDWWPADFGHYGPLMI
                     RMAWHSAGTYRISDGRGGAGAGQQRFAPLNSWPDNGNLDKARRLLWPVKKKYGQSLSWA
                     DLLILTGNVALEQMGFETFGFAGGRADVWEAEEDVYWGPETTWLDDRRYSGDRELENPL
                     GAVQMGLIYVNPEGPNGNPDPIAAARDIRETFGRMAMNDEETVALIAGGHTFGKTHGAG
                     PADHVGDDPEAASMEEQGLGWRNSFGTGKGGDAITSGLEVTWTSTPTRWSNGFFKNLFE
                     FEYELEQSPAGANQWVAKDAPEIVPDAHDPSKKHRPKMLTTDLSLRYDPIYEPISRRFY
                     ENPEEFADAFARAWYKLTHRDMGPKSLYLGPEVPEETLLWQDPLPEADGEPVDAEDVAT
                     LKTKLLESGLSVSQLVSTAWASASTFRGSDKRGGANGARIRLEPQRGWEVNEPDELAQV
                     LRVLEGIQQEFNSGTKKVSLADLIVLGGTAAVEKAAKEAGFQVQVPFTAGRVDATEEHT
                     DAESFEALEPVADGFRNYLGKGNRLPAEYLLLDRANLLTLSAPEMTVLVGGLRVLGANY
                     QKSPLGAFTRTPGSLTNDFFVNLLDLGVTWKSTSEDQTTFEGRDAATGEVKWAGSRADL
                     VFGSNSELRALAEVYASDDAKEKFVHDFVDAWVKVMNLDRFDLV"
     gene            complement(18707..19693)
                     /locus_tag="SAM23877_RS33050"
                     /old_locus_tag="SAM23877_6961"
     CDS             complement(18707..19693)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574709.1"
                     /locus_tag="SAM23877_RS33050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6961"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_053141210.1"
                     /transl_table=11
                     /translation="MSDERGRAPHRVVVFVRPGLLPMELGIVHRLFGTAADEDGRPLYS
                     VLTCATAPGEVATDTDFSVHVPHGPKVLESADTVVVPAAVEDYGPQRRGRLAAPVRAAL
                     ERVPASARLASICTGSFVLAATGALEGRRATTHWKSCAELASLYPEVDVDPDVLYTDDR
                     GVLTSAGVAAGIDLCLHMIREDHGVEVANRVARGTVVPPHREGGQAQYVDRPAPQADGA
                     STAAARTYALQRLGEPLTLEDLARQAAMSVRTLNRRFRQETGVTPMQWLGRQRLDYARR
                     LLERSDEPVDRIAARAGFGTGTAMRQHFREALGVSPRAYRNTFRGTA"
     misc_feature    complement(19712..19730)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            19765..21078
                     /locus_tag="SAM23877_RS33055"
                     /old_locus_tag="SAM23877_6962"
     CDS             19765..21078
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075556.1"
                     /locus_tag="SAM23877_RS33055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6962"
                     /product="MFS transporter"
                     /protein_id="WP_053141213.1"
                     /transl_table=11
                     /translation="MRPTTRHPRVLPGHRAWWTAAVTAATIVVAGAFSTMPGILQGPLH
                     GEFHWSRGSLGLAASVNMVLYGLTAPFAASLMDRFGVRRIVVTALGVVTAGALLTTVMD
                     AAWQFTLCWGLLVGLGTGALSMTLATTVANRWFTTRRGLVTGILSSAGVLGQMVFLPAL
                     SWTIDHHGWRPSLVTLAVAALVTLLLVRCTLGDHPADSGHHPYGSPAFVPKPAPVPGAA
                     RRALAVLRDAAHTAPFWLLATAFAVCGASTNGVMWTHFAPAAHDHGMPVTTASTLLALI
                     GVFNVAGTVAAGWLTDRLDPRRLLAVVLTARGLLLVALPALMSATVTPPMMAFVVLFGL
                     LDLATVPPVIALCRTFWGDDSAIVFGWTNAAHQVGAALAAFLGGVARDAFAGYDPVWTV
                     LGAACAAAALLALTVRRTPGVSVPRRGRKALAAPGTRC"
     gene            21088..22089
                     /locus_tag="SAM23877_RS33060"
                     /old_locus_tag="SAM23877_6963"
     CDS             21088..22089
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027205.1"
                     /locus_tag="SAM23877_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6963"
                     /product="phosphotransferase"
                     /protein_id="WP_079030579.1"
                     /sec_met_domain="APH (E-value: 2.3e-07, bitscore: 29.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREETSVVVDRGRFQDAVTPWEDEAWRAAAVGWVEGELTARGLRP
                     AGEWRVRLRPWSVLVRLPVPGRGAVWFKANPPAGAFEGALTAALSRWVPQHVLEPLAVD
                     ADRGWSLLPDGGRLLRDVLDRETTGPALWEELLRQYAAMQHALTSRVPEIERLGVPYLP
                     VTTLPDVLDRLDDTPLRPEERAGLGGVRPRVKEWCEELAAVGVPDSLDHVDLHDGQLFH
                     PAPGGFTFFDWGDAVVSHPFCSLTVPARRALERYGPRVLPRLRDAYLEPWTGAGRSTAE
                     LRRAVVLAWRLSALSRAGAYGRLFPGTSGAAAAQVAGEGARCLLELLDDPPW"
     gene            22139..22405
                     /locus_tag="SAM23877_RS33065"
                     /old_locus_tag="SAM23877_6964"
     CDS             22139..22405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027204.1"
                     /locus_tag="SAM23877_RS33065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6964"
                     /product="hypothetical protein"
                     /protein_id="WP_053141215.1"
                     /transl_table=11
                     /translation="MDEVEFMRGRVYGADHDSPGPRAGRVYVQLVGGPLDGLLLDVTDL
                     TERERGRGVVLATEIGRYGPGGRSAYGPRPDDRLRFDWRGDVP"
ORIGIN
        1 cgcgccctgg tcaccgccgc caccggcaag ttctactcca acgggctcga cctggactgg
       61 ctgttcgccc acgccgacca gcaccaggac tacgtcgtct ccgtccacgc actgttcgcg
      121 cggatgctct ccctgccggt cgtcacggtc gccgcactgc aggggcacac cttcgccgcc
      181 ggtgcgatgt tctccctcgc ccacgacttc cgggtcatgc gcgccgaccg cggttactgg
      241 tgcctgcccg aagcggacat caacatcccc ttcacccccg gcatggccgc cctcatccag
      301 tcccggctgg cgccccggac cgcccacgag gccatgctca ccgcccgccg ctacggcggc
      361 accgacgccg cggccgccgg cgtcgtcgac cgcgcggtca ccgaggacgc cgtgcgctcc
      421 accgccatcg agatcgccca ggcacaggtg aacaaggccg gtgacaccct cggcaccatc
      481 aaggcccgca tgtacgccca gcccctggcc accctgcgcg acaccaccgc acccctcggc
      541 tgaaccggca cgtcgccggc gaccgcgccc cgggcccgcc cgggggcgcg gtggccggcc
      601 gggcagtggg ccggggtgct tggggctagg cgctcctcct cggtttccgg gccgtcttct
      661 tcgccgcggt cttcttggcc ggtcccttct tcgccgtccg cttcttcggc atctcgtgca
      721 cgtccgcgtg cccgccggtg tcctcgccgc gggtggcctt cgccttcgac accgactcct
      781 gcagcgcggc catcaggtcg accagctgcc ccgactcggc cgccggctcc tccttcgcgg
      841 ccggtggttc acggtgttcc cgcttcgcct cgatcagctc ggcgaccgcc tccgtgtacg
      901 tgtcccggaa ctcctcgcct tcgagcccgt cgcgggtcat cgtgtccatg agggcgaggg
      961 ccccgtcgat ctcctcgtcg gtgagctcca ccggcggcgg ggtcagcgag gacgggtcgc
     1021 ggatctcgtc gggccagcgc atggcgtgca ggacgatcgc ctcctcgcgc acccgcagga
     1081 ggccgagacg ttcccggccg gaccaggcgt acctggcgac ggccacgcgg ctcgagcgct
     1141 ccagggcctg gcggagcagc ttgtacggtt tcgccgcgac ctgcccgtcc ggggccaggt
     1201 agtagccctc ggcgatccgg agcgggtcga cggactccca cggcatgaac gcgacgatct
     1261 cgatcgcctt cgccgtcggc agcggcaggt cccgcagctc ctcgtcgctg atcgggatga
     1321 cctgcgtcct ggacagctcg tagcccttgc cgatctccga ggaggagact tcgcggtcct
     1381 ccagctcgca caccttccgg gtccgcaccc gggccatgtc gtccaggtgt acccggtgaa
     1441 agtggatgct gtggtcctcg gtggcactga ccacgtcgat ggggacggtg accaggccga
     1501 agctgatggc gccggaccag atggtgcggg gcatgacgaa cctccaaggc ggccccgagc
     1561 gggatcagcc tacgagcgca ccggcggctc cgcacgcgct cggacgccat cgcctgctgg
     1621 gcgatcgagg gacgcggaca tcagcgccgt ccactgcgtt gatcgactgt caccgctcct
     1681 gcttcgggcg gccggcggag gcttgccggg tgtcggcgcc ggagctgacg tgtcgctggg
     1741 tttcctgggt gccgtgccag tccaggcaca tcacggtggc atcgtcctcg agccggccgc
     1801 cggcggcgtc ccggatcgcg gaggtcagca tcagcgtggt ttcccgcgga tggagactcc
     1861 gggtgcgccg cagcagggcg gggaggtcga tgtcctctcc atggcgttcg agcatgccgt
     1921 cggtgagcat gagcagacgg tcaccggggc gcaggtcgat gttctgggcc cggtaggagt
     1981 ggggctcgat gacggacaga ccgaagggtg ggtccacggc gcaggcgatc acgtccacgg
     2041 tgccgtcccg catccgcagg ggccaggggt ggcccgcgtt gacgagctgg gccacgccgg
     2101 tgtgcaggtc gacgcggagc agttggccgg tggcgtggcc gtggtcgtgg tcggccagtg
     2161 cccggtcggc gcggtgcgcc tggtcggtca ggctcgctcc ggcgcggcgg gcgccccgca
     2221 gggcgctcac caggacggtg gcggccaggg cggcggcgat gtcgtgtccc atggggtcgg
     2281 tcaccgacac gtggagggtg tcacggtcca cggcgtagtc gaaggtgtcg ccgctgaggt
     2341 ttccggaagg ctccaggttc ccgcacaggg cgaactgggc ggcctcgcac gacagcgacg
     2401 ggggcagcag ctgatactgg atctctgctg ccagcgtcgg gggcctggag cgtttgcccc
     2461 agttgtagag atcggtgaaa cgcccgttgg cgatcacgag gtagcccagg acgtgggcgg
     2521 cttcccctac cgcttccagg acgccttcgt cggggacggc aggcagcatc agttccagca
     2581 gcccgatcgc gtccccccgg ttggtgaccg gaacgatcat ccgctgcccc tggtcggtcg
     2641 cctcctggta caggcgctgg gtgcggatca cctgctcgta gacgctcccg aacaggggaa
     2701 tccgctgggc ctcccgcccg cccggcacgt ccgaggtggg cagtcgcgcc accgccttcc
     2761 ccgtcaggtc gacgatgagg aaggagatct ctctggcctc gaaacgtcgt cgcaggtgct
     2821 cggcgaccac gtcgacggcg tcgaccggcg cggctgtctc cgctgccgtc agcagccggg
     2881 gaagttcgat cggcccactg ctcacggcaa cggccccttt cagcgccccc actaacagct
     2941 tgggaactgt cacggggaac gtcaattctt gggcgagggg gctgggcggt cacagggact
     3001 gctgccgggt ctccgcatcg ttctcgatca aaatcaggtg cgaatgagcc ggtccgcact
     3061 cctatactcg tgcgggttca tggaggggga ggtggagaca gtgaagcttg ccgaggcatt
     3121 ggcagaacgt gcggaggcga cgcgccgcgt ggatcagctg cgagcacgcg ttgtcgacag
     3181 tgcgcggtac caggaggggg agacccccgc cgaggacgcg gctcagctgt tggccgaggc
     3241 cggcgaggta ctggacaccc tggaaacgtt gatccggcgg atcaatcgga ccaatgccgc
     3301 cgtggaggtg ggcccggacg gcacgctcac cgatgccctc gcgcgccggg acgtccttcg
     3361 gttgcgtcac tccgtcgtca ccgcggcggc ggacgcggca gcgggcaagg gtgagcgggg
     3421 atacggccgg cagctccgct ccgagctgct gatgctctcc gcgctcccgg tcgcggaact
     3481 gcgcggtcag gcggatgcgc tggcccggga gatccgcgag atcgatgtgc gcatccagcg
     3541 tgcgaactgg gaggtcgatc tgctggactg agcagtccgg caagccggaa cgatgtggag
     3601 caggtagcgg tttcggaggc gtgcacacac cgagggccgg cggttctccg gcccactcct
     3661 ggcgcgtgaa gagcaacgcg ggggttcgac tccccgatga cagtgcagct cagcatcgcg
     3721 tacaggtgac agtgcacatt gcacagcaca tcaccacgtg cagatccgag gcggcgaggg
     3781 cgggctcggg gctttccaca tcacagatca caccttcgcg aagcctggtc cctgggtctc
     3841 ggtgcacgac gaccacgcac cgtcaaccag tacctccgac gttcacttcg ggagctggtc
     3901 ggcgtggtcg tcctggagca tgtggcgacg ctcctgttcg cgcttggagt aggccgccgc
     3961 ccggatcgcc tcgtcgctct ccaggctcga ccccagtgcg ccgcccaccg tggcgaccga
     4021 agccacgaac caggacaacg tccagtactc cgtcgcttgc agcggggttc gtgtcatgga
     4081 ggcgaagact tggtcgttga ggatgaacaa cgcccacacc aagttgatga ccatcagacc
     4141 gacgtagcag accagcaccc cgatacccac ggtcacgacc gtggacgcgt tgtagagggc
     4201 agccctcctc ctcgcctccg gcgttccttc cgctgaccga tgccacaggt gcgcgtccac
     4261 gatcagccag ccgagcatga gcgcgacgga cccgaccatg gcgatcacca ggcgtggaac
     4321 gctcagggac gaggccaggc tccagatggt ggagttcacg gtggcgatgg cacccgtggc
     4381 gagtgcggcc gccagggctt tcgacagacc cgacaacagc cgccacggcc ggttggcgcg
     4441 gaccatcccg agaagcaccc tcaggtgacc gcgcggcccg ccggcgacat agcgcagatc
     4501 gacggactct tcctcaccga cgggacctgg acggacgggc gcgaggcggc cgacgaagga
     4561 ccccgccggc ggctggtccc gtggagttcc cccgttcccg gtggcccgcg gacccaccaa
     4621 gctgagcacg gcttcctcca ctgcccgccg ggctcttctc tgcagccgca agcctcccag
     4681 gggaggaagg gacagcagcg ccgaaccgtg tgcgtgactc agctccacca cgagctcgcg
     4741 cccgtgggag tgcagcggca ggtcggtgag cgctacgacg acgtcccagg tctccgcacc
     4801 cgcgcggtcc gagatccggc gcatcaaggt gggcgggtcc tcggtccccg cggtgaaggg
     4861 ctcactcacc acctcgacgt ggaaccgtcg cccctggccc gacctctcgg cgagccgatc
     4921 gggaagtgcc cgggccatgc gctgcgcgat ctccgtcggc gcgtccggat ccgccaggag
     4981 agccacgacc gtaatgccct gggacgacac gcgcatgact ccttctcgtc ggccgcactc
     5041 gcgatcgcag gtgcccacag gatgcctccg cggggggcgt cggagcgcac ctgccacgct
     5101 ggcgccggcg cgtgaacggc gcacacggcg aatgagtgag ccctgtacgc gcccccgcgg
     5161 gggtacggag aatgcgcagt gaccgtgatc acgcggcggt gccgtccgac cgccgccctc
     5221 cggggaaagc aggtcatcgt catgctggtg cgtctgccca cgtccgtgtc cgaagcgcag
     5281 gagtgcatgg cgcagggagc ggtgcccatc ggcggggcca cgctcgtgtg ggccacctgg
     5341 caacgggacg gctttcccga actggccatg tcgctgcgcg acctgccgga ggcgtccgtg
     5401 gtcgaacccg aggcgctggg ggcggccgtg gtgctgcacc ggatagacgc ccgggtgccg
     5461 gaggtactgc gcagggcggc cggcaccgtg ggcaccggag ccgtacgccg gacggccacg
     5521 gtcgggggca acctggtcgg cagcagcctg cgttgcctgc tgcccgcggc cctggtgctg
     5581 gacgcccggg ccacggtgct gggacccgac cgggcctacg agaccgatct gcccgaggtg
     5641 gtcgccaagc gccacctcct gctgggcctg cgctggcgca ccccgttggc cagcggatac
     5701 cgcaaggagc ccgccgaggc cggcggaccg ccgccgctgg tcgtcgccac cgccgtgcac
     5761 gccgtggacg ggggcccgcg gcagctgagg gtcgccgtcc gcgacggcta cgaggtgctc
     5821 agcgggaccg tgtcgtgcga cgcgggtgcc gacggggcct tcgacctgct gcggcgttcg
     5881 gatgtcggcg ccctgccccc cggggcccgg gacgtggtgc gtgagcaggt cgccgacatc
     5941 ctggattccc tcaccgagcg ctgacgcggc ggcacggacg ggcgggcctc agccgttggc
     6001 cagcgccttg acctggtcca gcgcgccgtt gaacttgtcg tggtccccga cggtcggccc
     6061 ggtggaggtg tactgccaca tcgtgtggaa gtcccagccg gccgggaggg ggcccacggt
     6121 cgaggcgtac cgggcgatcc acaacgggtt ggtggagccg aagccgctgt agtccccggt
     6181 gcactgcttc caccagttgg tggaggtgta gatcgcggcg tcgcggccgg tgcgcgcctt
     6241 gtagcggtcc aggaagtcgc cgatccacgc gaccatctga ctcgccgtcc tgccgtagca
     6301 ggtgtccccg tacgggttgt actcgatgtc gagcacgccc ggcagcgttc tgccgtcctt
     6361 ggaccagccg ccgccgtggt ccacgaagta gtccgcctgg gcggcaccgc cggcgccgtc
     6421 cggcgtcgcg aagtggtacg cgccgcggat catgccgacg tcgtacgaac cgccgtactg
     6481 ctgtgcgtag taggggttcc ggtaggaggt gccctcggtg gccttcacat aggcccactt
     6541 gaccccgctg ctccagaggg tcggccaggc gacgttgccc tgatggctgg agacgtccac
     6601 cccttcggtc tgggtgaccc gggtgtccgc gggctgtccc tggacccctt cgtgggccag
     6661 gacccccatg cccatgtggg cggacccgcg gacaggtgtc gcgcccgtcc cgtcggccga
     6721 cgcgggggcc gcgggcaggg tcaggagaag cgacgggacg gcgaggagga cgcctgacgt
     6781 gagcaggcga cgtgagtggc tgggcgccac ggctatgggt ctgcgcatgg cacccatccg
     6841 atccgctgtc gcgccggacc gcaccccacg ctcgtccaga cggtgtgggg gggggggtgg
     6901 gcccggtgcg gggcgacacc cggccgatcc gccggtttga acgtgttcaa atctgggata
     6961 tggtcgccgt acgacgaggg gggagcagcc catgaagatc gtgatccctg ggggaaccgg
     7021 gcaggtcgga acggttctgg gacgtgcctg gaccgccgca ggacacgagg tcgtggtgct
     7081 cagccgccgg ccggagcagc ggggcgaggt cccgtgggac ggcaggacgc cgggggactg
     7141 gttcaaggag atcgacggca gcgacatggt cgtcaatctg gccggccgca gtgtgaactg
     7201 ccgttacacg cccaccaacc tgcgggccat gatggactcg cgcgtgcact ccgcgcgcgt
     7261 cgtgggcgag gcgatcgcgg cggtcgccga gccgccccgg gtctggctgc agatgagcac
     7321 cgccaccgtc tacgcccacc gcttcgacgc accccacgac gaggccaccg gtgtggtcgg
     7381 cggccgcgaa gccgatgtgc cggcctactg gtcgtacagc gtcgagatcg ccaaggcctg
     7441 ggagcgggaa ctggagcgtg ccgacacccc gcacacccgc aaggtggccc tgcgttccgc
     7501 catggtgatg agccccgacc ggggcggagt cctggacgtc ctgctgcggc tggcgcgact
     7561 ggggctcggc ggccccgtcg cgggcggagc gcagtacgtg tcctggatcc acgagcgcga
     7621 cttcgtccgc gcggtcgagt tcctggccgg ccgcgaagac ctcaccggtc cggtcaatct
     7681 cgccgctccg tctccccttc cgcaacgtgc cttcatgcgc gccctgcggc aggcgcgggg
     7741 cgtaccggtc ggcctgcccg ccacgcggtg gatggccgaa ctcggcgccc tggtcctgcg
     7801 ctccgacacc gaactgctcc tcaagagccg gcgtgtcgtc cccggccgac tgctcgaggc
     7861 ggggttcacc ttcgaccacc ccgactggcc ggaagcggcc gaggacctcg tggggcgggt
     7921 gcgcgggtcc cggtgagcag acgggcgcga aagggtcgcc tcgtggcccg tggcgcctgc
     7981 cggtggcccc gggcggcggg gcgtgtccgt gtcctccgcc cgggagggcg ttcgctcagt
     8041 ccgctcgggg tgtgaaccgg accggcagcg actgcgggcc ccgggtgaac acgccccgct
     8101 ccaccgcgtc gaacccgtcg gcgggcgtca gatcgggcat ggcgtccaga agctggccca
     8161 ctccgatctc cacctctgcc ttcgccagca gcgccccgac gcagaagtga cggccgaggg
     8221 cgaaggcgac gtggtcggcg gcggccgaga aggcggtcgt cgtggtcagg tcgtcgcgca
     8281 ggatgtcgaa gcggtccggg tcgtggtagc ggctctcgtc gcggttggcc gagccgatga
     8341 ggcaggtgac ggtggcgccc gccgggacgg tgccgccgct gagctcgacc tcggtcgccg
     8401 actggcgcat gatcatgtgg acgggcgggg tgtggcggag cgtctcggcg aaggcccggg
     8461 cgatcagggt ccggtcctcg cgcacggccg ccaactggtc cgggtgggcc agcaggttgg
     8521 cgaagatgct cgcgatcgcc ttgtccgtcg tctcgccgcc ggccgcgagc agcaggctgc
     8581 agaaggcctt gatgtcctcg tcgctcatcc tgaccccgtc gacctcggcg gcacacaggg
     8641 tggacagcag gtcgtcgccc gggttctcac gacgctcctg gatgaccggg aacatgtact
     8701 cggcgaactc cacccgggta cgcgcaccgg ccgccgcgat ctcggggtcg cccgcgaggt
     8761 tgccgaggaa ggcgatgacg gacgtgtacc agccgtggaa gcggtcgtgg tcggccttgt
     8821 ccagccccag catgtccgcg atgacgttga cggggaagcg ggtcgcgtag tcgctcacca
     8881 gatcggcccg gccggtgtac cggaacgcgt cgatgagctc ccgggagttg cgctcgatca
     8941 cgggcaggaa gcgctcctgg agatcggtgc cgcggaaggc gggggcgacc agcgcccgcc
     9001 ggaccgcgtg ctcacgaccg ctgagctgca ggatcgtcct gccgtgcacg ggctcgatct
     9061 gccagtcgta gttctcggtc gtgaactgcc cgtcccggtc cttgaagacg cgttccacgt
     9121 cctcgtagcg cgagacgatc cagctccgcg tggcctcgtg ccagaagagc ggcgcaccct
     9181 cccgcatcgc gcggtaggcc ggataggggt tcgccgcgaa ctcggcggag aggatgtcgg
     9241 ggacctgctg ggcggcggac atgaggctcc tgggtcgaca acggccgtac cgcgtcaggc
     9301 tattcacgaa gcgacggcac cgacagccca ggccggcgcc cggcatcgcg acggtgaccg
     9361 ggcgggcccc gggaatggac caccggccgg cgctgttgac tgcggtgact gacatgcgcg
     9421 ggacagatag atccgcagcc cgcgccgtgg tcggaaggag caccatggca cgcagcaccg
     9481 cacgcccggt cgtcaagctg aggtcgacgg cgggcaccgg cgtcacctac gtgacgcgca
     9541 agaatcggct gaacgacccc gaccggctcg tcctgcgcaa gtacgacccg gtggcggggg
     9601 agcacgttcc gttccgcgag gaacgctgaa cggcgcgacg gagccaggga gccaggaggc
     9661 gatcatgaag gtgcgtaagt ccttgcgcgc gttgaaggcc aggcccggcg cacaggtggt
     9721 gcgtcgccgc ggcgtgacct atgtgatcaa caggcgggat ccgcgcttca aggcccgcca
     9781 gggctgaacc gcgcgtaccg ccgaggcccg gccccgcgac ggcggagccg ggccccgtca
     9841 tgtccgtgat cgcgccgtcc cgcgaccgcg ccgccgtgag cccgcccgca tgcgggagag
     9901 cggcgacctc cgacgggagg ccccgagccc ccgccgtccc cgggcgcgcc acctgacaca
     9961 ctgcggggcg acacccgccc cgccccagga ggaccccgcc atgtccgagc agccgctgga
    10021 ccgtgccgcc cggtgcgcgc gccggttcga cgtgctcttc gcggagtact tcgagacgct
    10081 gagcgcgacg ctggaggcgc cgtcgttcag ccggttcacc ccggagtgcc tggaactgct
    10141 gcgcgacctg tccctgcggg gcggcaagcg gatgcgggtc gtgctgctgc acgaggccgc
    10201 gcgcctggtg cgggacgagc ccgtcgacgg actggacgcc gccgcgctga gcatcgagct
    10261 gctgcagacc cacggcctgg tgcacgacga cctcatcgac gacagcgcca cccgccgggg
    10321 cggaccgacc acctaccacg cctaccggga gcggttcccc cggcacccgc aggccgcgct
    10381 cgggctcacc gtcctcgcgg gagacctcgc gctcgccctc tccctgcgcg tgctgctgga
    10441 cgccgagctc ccggtcgagg tgcggcaggc catggtggag gtccagacac gcgccgcgac
    10501 cgacaccttc gtggggcaga tcgccgacct ggagcgcgac ttcgcccccg cggtcccgga
    10561 cgacgacgtc ctgcacgacg tggccgacca caagtccgcc cgctactcgg tcctcgcccc
    10621 gctgtacctc gggctcctgg ccgcgggcga acagccggcc gccttcgagg aggagttgcg
    10681 tcgctacgcg cgcctggtcg gcatctgcgg ccagatgcgc gacgactacc tggacctgtt
    10741 cggcgacgcg gccgccatgg gcaagccgac gggcaccgac ctccgcgagg gcaggcgcag
    10801 ttacaccgtc gcccgcctgt tgtccgcggt gagcggcgcc gagcgcgtcc tcgtggaagg
    10861 ggccctcggg gaccgggcct gcacaccgga gaccgtcgcc gccgtacggg agatcgggga
    10921 gcgtcgcggc gtggcttccc gcatgcgggc ggacatgcga cgctacgccg agcaggccgg
    10981 ccaggtggcc gcgggctggc gtccgcggtg gcgcgaggac gcggtcggct tcttcgagcg
    11041 gctgccgatg tggagcgtcg agcgggccgg gtgaaccgcc gtctcgccgc ggtacgaggg
    11101 ggacggtcgc ggttcggagg caggtcgcgg tccgaggaca gtggccgcgg tcttcaggaa
    11161 ggccgtcgcg gacgagggag agccgtcgcg gtccaaggga aagcaaggga acgaacatgg
    11221 ctgtgctgtt tctgtccggc atcctcgtcc tcgtcctcgc ggggtgtgcc tgcgtcgtgt
    11281 gggcggcgcg gggagggccg cgctgggtgc gagcggtgtc cgccgtgacc cttgcggcgg
    11341 gtgagctggt gcgcggtgcg aagggctccg gcagaagcgc gggcgggaga agcgctgcgg
    11401 acgactgagc agcccgtccg acgccagttc cccggaccgc tcaccagttc cccgcgtcgc
    11461 tcaaaggggt attcgggatc ttctgcccgt tccatccggt catgatctga ccggatgcgc
    11521 cgctgaccag gcgcatcggt gacggcgcga tctctgggga gaagcatggc gcacgcgacg
    11581 cgacggggca gaggccggga cgaccaggcc gtgctggtgg tcgccggact cgccgacctg
    11641 gcggtgagca cgctcggttc ggcggtgggc gcggtccgcg ggctcctgcg ccgctcggac
    11701 accgccgacc tggtgaggga ggcggaacag gatctccagg cccggggcag gctggccctg
    11761 gagcggtgca ccaacgtgcc gcccgcccac ctggaggtac tcgcccagca cgtacgcgtg
    11821 cgacgggcgg ccgacggcgt cgatgactga ccgctgggac ccggccgcct tcaaggtccg
    11881 tgtcgacggc gtactgcgga gctacgtgga cgaggaggcc ggtcacctgg tggccgtcga
    11941 cgacgccctc gcccccgtgg ccgagcagct gcgcggcgcc gccgggcacg gcaagcgact
    12001 gcgagccgcc ttctgctact ggggctggcg agcggccgga cagcccgacg acgacgcgct
    12061 ggtgcgagcg gcggccgcca tggaactggt gcacgccgcg gcgatcgtcc acgacgacct
    12121 catcgacgac agcccgctgc ggcacggtct gcccaccgcc cacgtcgccc tggaagccgt
    12181 actggcccgg gacggccgcc gtcggccccg cgccgccgcc cggtccctgg ccatgctggt
    12241 gggcgatcac ctgatggccc tcgcggggca gctgttcgcc ggcagcggcc ttcccgccgc
    12301 ctacctcgcc cgtgcccggg gtctgtgggc cgagctcgcc cgggaactcg tcgccggtga
    12361 gtgcctggag atcctgcaca ccggcggacg accggacacc gggacctcgc tcaaggtggt
    12421 ccggtacaag accgccaagt acaccgtcga acaccccctg ctcatcggcg gcctgctcgc
    12481 cggcgccggc cccggactgc gggaggccta ctccgcctac ggcctgccgc tcggcgaggc
    12541 gttccagctc cgcgacgacc tgctcggtct gttcggggac ccggagcgca ccggcaaggc
    12601 gggcctggac gacctgcgga cccaccggcc caccgccctg ctggccgaga cctgggaggc
    12661 cgccgacgcc tcccagcggg agcggttgcg cggcgtgctg ggccgcagcg acctggacga
    12721 gacgcacctg cgcgaggtgc gcgccctcat gcgggagctg aaggccccgc aacgcgtcga
    12781 gcggatgatc ggcgcccgcg tggaacgggc cacccgcgcc ctggactccg ccgacacgcc
    12841 accgcacgcg cgccgggtgc tgtacgccct cgcccagcag gccaccgacc gcatccactg
    12901 acgaggagac cgcgatgacc tacaccgaga cctcgatgga cgccctgcgc cgcagcggcg
    12961 acgacctggc cgacgccgtc gtggccaccc tgttcgagcg cggcgaggtc ggcaagttca
    13021 actccctgat gcgctacgtc tccaccgccg gccaggccct gccggacggc ctgcccgggg
    13081 tggccaggga gtacctgcga gtgaccggcg ccccgcccga ctgggtggac tggagcgaga
    13141 tggagagggc ccgcctcttc ttcatcgaca acaacgtgca catctccacc gcgttgtcct
    13201 tcgcctccat gcccgcctgc tacgtcgtcc cgcacgtggc ccggctgctg tcggccaccc
    13261 acggactgag ctacccctcc aaacgcatgg cggagaccgg ccagttcacc gtctacctga
    13321 tgcaaccgga cgccttcgag gccgggggcc gcttcatccc ggccgcccag aaggtgcgtc
    13381 tgctgcacgc cgccatccgc caccacctga agcgggagga ccgctgggac accgatgccc
    13441 tgggcgtacc gatctgccag gaggacatga tcggcgggca gatgttcttc tccctgctgg
    13501 tcctggacag cctgcaccgt ctcggtatcc acatgtcggc cgaaggggcg gacgcgtact
    13561 tctacgcctg gcgcgtggtc ggtgccatgc tcggtgtcga ccagacggcc gtccccggca
    13621 cgctcgacga ggcgcgccag ttccttgacc tgtacatgct gcgccacatg ggcccctccg
    13681 aggagggcgc ccatctgacg cggcagttga tcgacctgta cgaggaagtc gtcccgggca
    13741 ccctcttcga cccggtggtc tccgccctga tccgctacct cgtcggggac acgtgcgccg
    13801 actggctgga agttccccgc accacctggg acacgctggt gaaggccact ccgcacctgc
    13861 tgggcgtcct ggagacgatc gaggaccgct caccgctggg cgcgtgggcg ctggaccgga
    13921 tcggccacct caccacggtc ctcgaactgt cctccctcac ccgcggacgc gtcatgcact
    13981 acgccgttcc cgaacaactg aggaaggatt acggactctc gggcgccgcg gcccgcaccc
    14041 ggcgctggac gccgccgccc gccaccgtct cctgagccgc ggccggccgt cgcgggccgg
    14101 acgggaccgg cgggcgtcag gcgatggagg ccgatatgac cgcggagacg gcgaggttgc
    14161 aggacgccgt gacccacacc gcggggtggg gctccggctc gaccagcgtc gcgcccagcc
    14221 gccccggggt gatgaggtcg accacgagga atgccagggc catcatcacg agccccagca
    14281 gtccgaacgc cgcggtggac accagcccct tgccgaagtc ctcgtacgtc gtccagatgg
    14341 acgtgaacac gatgccgccg atgccgagca gcgcggaact gagcaccatc gccgcgttgc
    14401 ggttgcgctg ttcccagatc tgccggccga gcttcccggg cgtcagcacg tccacgagga
    14461 cgatgccgag gaccaggagg accaggccga ggccgccgta ggcggcggca cggccgagtc
    14521 cgttgacgat gtcgctcatg ggggtgccgg ctccgtagcg tgagggatcg ggggtgatcg
    14581 tggtcgaggc gctgcaaaat gtagcgcacc cgttcgaccc catggccctg cggtcggcga
    14641 tcccgcggtc cggccgggac ccgacgtcag gagccggccg cgagggcgcg gttgcggcgg
    14701 acggaggacc agaaggaggc gccgatcagg acgacgccga tgaggccggt gacgacctcg
    14761 ttgatctcgt actcgatggt gaccaggagg atgacggcga gggcgccgat ggcgtagtgg
    14821 gcgccgtgct ccaggtacac gtagtcgtcg agggtgccct ggcggaccag gtagacggtg
    14881 agcgaccgga cgtacatggc gccgatgccg aggccgaggg ccatcaggac gatgtcgttg
    14941 gtgatggcga aggcgccgat gacgccgtcg aaggagaacg acgcgtccag gacctccagg
    15001 tagaggaaca tgaagaacgc ggccttgccg gtgagggcga cggccgaacg gttcccgccg
    15061 gaacgcgccg ccgctgtctc ggcgtcacgc tcacgctcct cctcccgttc gagcctgtcc
    15121 tcgaagaagc cggagagacc gccgacgacc atgtacgtga tcagaccgcc gataccggcg
    15181 aggagcaccg tctccgcctt gtcggcgtgg atgccgccgt gctggtgggc gtgggcaccg
    15241 aaggtgatcg cggagaccag cagcacgatc agtgcgacgc agaccgacag catgtccacc
    15301 ttgccgagct tggccagcgc gcgctccagc ggaccgagcc acttgatctc ccggtcctcc
    15361 aggacgaagt cgaggaagat catcaggagg aacatgccac cgaaggcggc gatcgacgga
    15421 tgggcgtccg tcaccagctc ctggtagcgc tccttgtccg tgagcgccag gtgcaccgcg
    15481 gaccacgggc tcagccgggc actgaccgcc acgatgacga cggggaagac caggcgcatg
    15541 ccgaagacgg cgatcacgat gccgacggtg aggaagatct tctgccagaa ggcactcatc
    15601 ttcttcagga ttccggcatt gatcaccgcg ttgtcgaagg acagggagac ctccagcacg
    15661 gcgaggatcg cgacgaggcc gaaggcggtc cacccctcgt acagcactcc cgcggccagg
    15721 cccagggcgg tgacggcgaa ggcccaacgg aacgtcttca caagcacggg ctactcactc
    15781 actcctgttg tcgcgctgcg ccggatccgg cgttccctgc cagtgccccg cacccacgtt
    15841 gtctaccacg atcgatcacc gtcaccgggg cacgcccggc tcggcgccgc ccgcggcacc
    15901 ggaccgtcac caaaatggat cgcttcgttt ccttgaggct ttcgtgtttg gcggagtagg
    15961 ttcccgccat gaccgcatcc ccggatacgg ccgtcgcctc cgagctgcgc ggggccggtc
    16021 tacgcgtgac cgcagcccgc gtcgcgttgc tcgagaccgt ccggcggggc ggtcacctcg
    16081 acgccgaggc gatcgccgcc ggtgtacgcc ggcgcgtggg ccacgtctcc ctgcaagccg
    16141 tgtacgaggc gttgcacgcg ctcaccgcgg cgggactcgt gcgccgcatc cagccgcccg
    16201 gcggcccggc gcggttcgag gggcgggtgg gggacaacca ccaccacgtc ctgtgccggt
    16261 cctgcggcgc cctcgccgac gtcgactgcg ccgtcggcga ggcgccttgt ctgaccgcct
    16321 ccgacgacca cggcttcgcg atagacgagg ccgaggtcat ctaccggggc ctgtgccccg
    16381 actgctccac ccccggcagt accccagcac cttgatccgc ccctccggaa ggatgtccat
    16441 gtccgagaac cacgacgcca tcgtgaccga cgcgaaaacc gaggaggccg gtggttgccc
    16501 ggtcgcccac ggacgcgccc cgcaccccac ccaggggggc ggaaaccgcc agtggtggcc
    16561 ggagcggctc aacctgaaga tcctcgccaa gaaccccgcg gtggccaacc cgctgggtga
    16621 cgggttcgac tacgccgagg cgttcggttc gctcgacctg ccggccgtga agcgcgacat
    16681 cgccgaggtg ctcaccacct cgcaggactg gtggcccgcc gacttcggcc actacggccc
    16741 gctgatgatc cgcatggcct ggcacagcgc gggcacctac cgcatcagcg acggccgcgg
    16801 cggcgccggc gccggacagc agcgcttcgc cccgctcaac agctggcccg acaacggcaa
    16861 cctcgacaag gcccgccgcc tgctgtggcc ggtcaagaag aagtacggcc agagcctgtc
    16921 ctgggccgac ctgctgatcc tcaccggcaa cgtcgccctg gagcagatgg gcttcgagac
    16981 cttcggcttc gccggcggcc gcgccgacgt gtgggaggcc gaggaggacg tctactgggg
    17041 tcccgagacc acctggctcg acgaccggcg ctacagcggc gaccgcgagc tggagaaccc
    17101 gctcggcgcg gtccagatgg gcctgatcta cgtcaacccc gagggcccca acggcaaccc
    17161 ggacccgatc gccgccgccc gcgacatccg cgagacgttc ggccgcatgg cgatgaacga
    17221 cgaggagacc gtcgcgctga tcgccggcgg ccacaccttc ggcaagaccc acggcgccgg
    17281 cccggccgac cacgtcggcg acgaccccga ggccgcctcc atggaggagc agggcctggg
    17341 ctggcggaac agcttcggca cgggcaaggg cggggacgcc atcacctccg gcctggaggt
    17401 cacctggacg tccaccccga cccggtggag caacgggttc ttcaagaacc tcttcgagtt
    17461 cgagtacgag ctcgagcaga gcccggccgg tgcgaaccag tgggtggcca aggacgcccc
    17521 ggagatcgtc cccgacgcgc acgacccgtc gaagaagcac cgtccgaaga tgctcaccac
    17581 cgacctctcg ctgcgctacg acccgatcta cgagccgatc tcccgccggt tctacgagaa
    17641 ccccgaggag ttcgcggacg ccttcgcccg cgcctggtac aagctgaccc accgtgacat
    17701 gggcccgaag tccctctacc tcggcccgga ggtgcccgag gagaccctgc tctggcagga
    17761 cccgctgccg gaggccgacg gcgagcccgt cgacgccgag gacgtcgcca ccctgaagac
    17821 caagctcctc gagtccggcc tgtccgtctc gcagctggtg tccaccgcgt gggcctcggc
    17881 gtccaccttc cgcggcagcg acaagcgcgg cggtgccaac ggcgcccgca tccgcctgga
    17941 gccgcagcgc ggctgggagg tcaacgagcc cgacgagctg gcgcaggtcc tgcgggtcct
    18001 ggagggcatc cagcaggagt tcaactccgg cacgaagaag gtctccctgg ccgacctgat
    18061 cgtcctcggt ggcaccgccg ccgtggagaa ggccgccaag gaggccggct tccaggtgca
    18121 ggtccccttc accgcgggcc gggtggacgc cacggaggag cacaccgacg ccgagtcgtt
    18181 cgaggcgctg gagccggtcg ccgacgggtt ccgcaactac ctcggcaagg gcaaccgcct
    18241 gccggccgag tacctgctgc tcgaccgggc gaacctgctc accctgagcg cgcccgagat
    18301 gaccgtcctc gtcggtggcc tgcgggtcct gggcgccaac taccagaagt ccccgctcgg
    18361 tgccttcacc cggacgccgg gctcgctgac caacgacttc ttcgtgaacc tgctcgacct
    18421 gggcgtcacc tggaagtcga cgtccgagga ccagaccacg ttcgagggcc gtgacgccgc
    18481 caccggcgag gtcaagtggg ccggcagccg cgccgacctg gtcttcggct ccaactccga
    18541 actgcgggcg ctcgccgagg tctacgcgag cgacgacgcc aaggagaagt tcgtgcacga
    18601 cttcgtcgac gcctgggtca aggtcatgaa cctcgaccgc ttcgacctgg tctgatccgt
    18661 cggtgtccgg gccggcccgc agctcgccgg cccggacacc ctcggactac gccgtcccgc
    18721 ggaaggtgtt gcggtacgcc cgcggcgaca cacccagcgc ctcgcggaaa tgctggcgca
    18781 tcgccgtccc ggtgccgaac ccggcgcggg cggcgatgcg gtcgaccggc tcgtcgctgc
    18841 gctccagcag ccgccgtgcg tagtcgagtc gctgccggcc gagccactgc atgggcgtca
    18901 ccccggtctc ctgccggaag cgccggttga gggtccgcac gctcatcgcc gcctgccgtg
    18961 cgaggtcctc cagggtgagc ggctcgccca gccgctggag cgcgtaggtg cgggcggcgg
    19021 ccgtggaggc gccgtcggcc tgcggggccg gccggtcgac gtactgcgcc tggcccccct
    19081 cgcggtgcgg tggcaccacg gtcccgcgcg ccacccggtt cgcgacctcc acaccgtggt
    19141 cctcgcggat catgtgcagg cacagatcga tcccggcggc gacgccggcc gaggtgagca
    19201 cgccgcggtc gtccgtgtag agcacgtccg gatcgacgtc cacctccgga tacagcgagg
    19261 ccagttcggc gcacgacttc cagtgcgtcg tggcccgacg cccctccagc gcgccggtcg
    19321 cggccagcac gaaggagccg gtgcagatgg acgccagccg ggccgaggcc ggaacccgct
    19381 ccagggccgc ccgcaccgga gcggccagcc gcccccgccg ctgcggcccg tagtcctcca
    19441 cggccgccgg taccaccacc gtgtcggcgc tctccaggac cttcggcccg tgcgggacgt
    19501 gcacgctgaa gtccgtgtcg gtggcgacct cgcccggcgc ggtcgcgcac gtgaggaccg
    19561 agtacaacgg ccgtccgtcc tcgtcggcgg ccgtcccgaa gaggcggtgc acgatcccca
    19621 gttccatcgg cagcaacccg ggacgcacga acaccaccac ccggtgcggc gcccgtcctc
    19681 gctcatcact catgaccaga ttctttcact cactgtccat ctggccagtg gtctgtggtc
    19741 cgcgtccggc gaagggtggg gcgcatgcgc cccacgaccc gacacccccg cgtcctcccc
    19801 gggcaccgcg cctggtggac ggcagccgtc accgcggcca cgatcgtcgt cgccggtgcc
    19861 ttctccacca tgcccggcat cctccagggc ccgctgcacg gcgagttcca ctggtcccgc
    19921 ggttccctcg gcctcgccgc gtcggtgaac atggtcctgt acggcctcac cgccccgttc
    19981 gccgcctccc tgatggaccg cttcggcgtc cggcggatcg tcgtcaccgc cctcggcgtc
    20041 gtcaccgcag gagcactgct caccaccgtc atggacgccg cctggcagtt caccctctgc
    20101 tggggcctcc tggtgggcct cggcaccgga gcgctgtcca tgaccctcgc caccaccgtc
    20161 gcgaaccgct ggttcaccac ccgccgcggc ctggtcaccg gcatcctctc ctcggccggc
    20221 gtcctcgggc agatggtctt cctgcccgcc ctgtcctgga ccatcgacca ccacggctgg
    20281 cgcccgtcgc tggtcacgct cgccgtcgcc gcactggtca ccctgctcct ggtccggtgc
    20341 accctcggcg accaccccgc cgacagcgga caccacccct acggcagccc cgccttcgtc
    20401 cccaagccgg cccccgtccc cggcgcggcg cggcgcgccc tcgccgttct gcgcgacgcc
    20461 gcgcacaccg cccccttctg gctgctcgcc accgcgttcg ccgtctgcgg tgcctcgacc
    20521 aatggcgtga tgtggacgca cttcgccccc gccgcccacg accacggcat gccagtcacc
    20581 accgcctcga ccctgctggc cctgataggc gtcttcaacg tcgccggcac cgtcgccgcc
    20641 ggatggctca ccgaccggct ggacccgcgc aggctgctgg ccgtcgtcct caccgcacgc
    20701 ggtctgctcc tcgtcgcgct gcccgccctc atgagcgcga ccgtgacgcc gcccatgatg
    20761 gccttcgtcg tcctcttcgg gctcctcgac ctcgccacgg tgcctcccgt catcgccctg
    20821 tgccgcacgt tctggggtga cgacagcgcc atcgtcttcg gctggaccaa cgccgcgcac
    20881 caggtcggtg ccgccctggc cgccttcctg ggcggcgtcg cccgtgacgc gttcgccggc
    20941 tacgacccgg tgtggaccgt cctcggcgcg gcgtgcgccg ccgcggccct cctcgcgctc
    21001 accgtccgcc gtacgcccgg cgtgagcgtg ccccgacgcg ggcgaaaagc gctggccgcg
    21061 cccggaacca ggtgctgaga tgagctgatg cgcgaggaga cgtcggtggt ggtggaccgg
    21121 ggacggttcc aggacgccgt gaccccctgg gaggacgagg cctggcgggc cgccgccgtc
    21181 ggctgggtgg agggcgagct caccgcccgg gggctgcggc cggcggggga gtggcgggtg
    21241 cggctgcgtc cctggtccgt cctggtgagg ctgcccgtcc cgggacgcgg cgcggtgtgg
    21301 ttcaaggcga acccgccggc cggtgccttc gagggcgcgc tgaccgccgc gctgtcccgc
    21361 tgggtgccgc agcacgtgct ggagcccctg gcggtggacg ccgaccgggg ctggtcgctg
    21421 ctgcccgacg gagggcggct gctgcgggac gtactcgacc gggagacgac cggccccgcc
    21481 ctctgggagg agctgctgcg ccagtacgcc gccatgcagc acgccctgac ctcgcgcgtg
    21541 ccggagatcg aacggctggg agtcccgtac ctgccggtca ccacgctgcc cgacgtcctc
    21601 gaccggctcg acgacacccc gctgcggccc gaggagcgcg cgggactcgg gggagtgcgc
    21661 ccccgcgtca aggagtggtg cgaggaactc gcggccgtgg gcgtccccga ctccctcgac
    21721 cacgtcgacc tgcacgacgg ccagctcttc caccccgcgc cgggcgggtt caccttcttc
    21781 gactgggggg acgcggtcgt ctcccacccc ttctgcagcc tgacggtccc cgcccgccgg
    21841 gccctcgagc ggtacgggcc gcgggtgctg ccgcgcctgc gggacgccta cctggagccg
    21901 tggacgggcg ccgggcgcag cacggcggag ctacggcgtg cggtggtcct cgcctggcgg
    21961 ctgagcgccc tgagccgggc cggagcctac ggcaggctgt tccccggcac gtccggtgcc
    22021 gcggcggcgc aggtcgccgg ggagggcgcc cgctgcctgc tggaactgct cgacgacccg
    22081 ccgtggtgag gacgccgccc ggcaggcgtt gtcagtggcg gatgcgaggc tgcgtgtcat
    22141 ggatgaggtg gagttcatgc gcggcagggt ctacggcgcc gaccacgaca gccccgggcc
    22201 gcgggccggt cgcgtctacg tccagttggt cggcggcccg ctggacggtc tgctcctgga
    22261 cgtcacggac ctcacggagc gcgagcgggg caggggagtg gtactggcca cggagatagg
    22321 ccgctacggc ccgggcggac gctccgcgta tggtccgcgg ccggacgacc gcctgcggtt
    22381 cgactggcgg ggcgacgtgc cctgacctcc cgtcgccggc ggcgcccccg tctccccgag
    22441 cagggccgcg agcagccagt cgtgcgcgga gccggggctc ggctcgggcc gacgccccgg
    22501 cggggtggtc acctcggcga ccagctccca gtagcggtcg atccgcgggt ctgccgggag
    22561 ctgccgggcc agccggcggc ggaagtccgg agtgtcccgg acgccgtacg cgctcgtgta
    22621 cgcggcgacg aagccgtcca gcgcctcgcc gggacccggg ggccggtccc ggcgcatgtg
    22681 gacgcccgcc agctcgtacg cctccgccag cccttcgtac agcacggcgg cgccccgggc
    22741 gccggccacc cggtgcgcct cgggctgggg ccgcgcggta cccggacagg gggcgaggac
    22801 gagggcgttg aggcgcgcga aggcgaggac ctgggccggg gccggatcgt cgggcggcct
    22861 cggcaccgcc acctccagga aggcaccggt ggaccgggcc g
//
