LOCUS       NZ_CP012382            21032 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7277127
            Orig. end                         :: 7298159
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21032
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="23"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21032
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21032
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11032](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11032)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(37..699)
                     /locus_tag="SAM23877_RS31975"
                     /old_locus_tag="SAM23877_6736"
     CDS             complement(37..699)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389369.1"
                     /locus_tag="SAM23877_RS31975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6736"
                     /product="DUF4230 domain-containing protein"
                     /protein_id="WP_053140769.1"
                     /transl_table=11
                     /translation="MTTPIRNLPRRVPGWAKVLSAIVLVLAVLFAGLRLSVVPGLKDLF
                     GTETQDRSGPALLESIQDMSRYEAASGNFQVVVDLEKDTKFLPDAIRGSRTLYVGAGTV
                     DAYVDLGKVGDDDVTVDDDRTSATLRLPHAALGEPALDPDRSYAVSKQRGLLDRLGDLF
                     SDNPNGEQAVQKLAARHIGDAAKDSELTARAETNTTAMLQGLLRSLGFEKVRVTYGS"
     gene            complement(816..2693)
                     /gene="otr(A)"
                     /locus_tag="SAM23877_RS31980"
                     /old_locus_tag="SAM23877_6737"
     CDS             complement(816..2693)
                     /codon_start=1
                     /gene="otr_A_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068508.1"
                     /locus_tag="SAM23877_RS31980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6737"
                     /product="tetracycline resistance ribosomal protection
                     protein Otr(A)"
                     /protein_id="WP_053140772.1"
                     /transl_table=11
                     /translation="MHIPNTLNIGILAHVDAGKTSLTERLLFDHGAIDRLGSVDAGDTR
                     TDDGGIERRRGITIRSAVAAFTVGDTQVNLIDTPGHSDFVAEVERALEVLDGAVLLLSA
                     VEGVQARTRVLMRTLRRLRLPTLVFVNKIDRAGARTEELLADVRRLLTPHVAPLTEVTG
                     AGTGHARVTRRTPDGRTAEALAEVDPGILAALVDGPEPTAGELAAALAARTADGSFHPL
                     HHGSALGGQGVAELVESLLRLVPPASPPAAGPAAPRGTVFALRPASGGERTAYLRLHAG
                     EVRPRQRLTFLRRESDGRTTEVTGRVTRLDVIGRPGTLTAGNIAALTVPGGLRVGDRLG
                     ARTDRAPQFAPPTLETLVRARHPGQAGPLRAALLDLADQDPLLHARPAASGATALLLYG
                     EVQMEVLAATLSEDFGIEADFAPGRARFLERPAGTGEAAEEMPWLDRTRYWATVGLRVE
                     PGPRGSGGVFAHETELGALPRAFHQAVEETVHATLLTGLTGAPVTDYRVTLTRSGFSSP
                     VSTAADFRGLTPIVLRRALGRAGTRLHEPLHAFEAEVPPDALAPVTARLASLGAEFTGT
                     TGGGSGWLITGELPARRVREAELGLPGLTRGEAVWSSRPSGDRPLDPPR"
     gene            2896..3849
                     /locus_tag="SAM23877_RS31985"
                     /old_locus_tag="SAM23877_6738"
     CDS             2896..3849
                     /EC_number="2.7.6.1"
                     /GO_component="GO:0002189 - ribose phosphate
                     diphosphokinase complex [Evidence IEA]"
                     /GO_function="GO:0004749 - ribose phosphate diphosphokinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978078.1"
                     /locus_tag="SAM23877_RS31985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6738"
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="WP_053140775.1"
                     /transl_table=11
                     /translation="MRDIAVFSGSAHPELAEEVCAHLGVPLSPTRVSRFANDCLEVQLR
                     ANCRERDVFLVQPLVKPVQEHLVELLLMCDAARGASAGRITVVMPHYSYARSDKKDAPR
                     ISLGGRLVADLLVAAGASRVLAMTLHSPQVHGFFSVPVDHLHALRELAAHFRQYDLSRT
                     TVVSPDLGNAKEAAAFARMLGAQVAAGAKQRYADDRVSISAVIGEVAGRDVIVLDDEIA
                     KGSTVLELLDRLREAGPRTIRLACTHGLFASGALKRLSDQPDVLEIVCTNTVPVPADDH
                     TEKLRVLSIAPALAEAVRRIHNGESVSALFDAPPGG"
     gene            complement(3815..4201)
                     /locus_tag="SAM23877_RS31990"
                     /old_locus_tag="SAM23877_6739"
     CDS             complement(3815..4201)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327710.1"
                     /locus_tag="SAM23877_RS31990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6739"
                     /product="anti-sigma factor antagonist"
                     /protein_id="WP_053143070.1"
                     /transl_table=11
                     /translation="MRYEPASPTGHLHVRQEHGHTVLELRGEIDIASAAEIAPRLEREA
                     GRPGARVVLDLSGVEFFDCSGLRLLYRARRQVLDHGGQVHLVCTHPLTLRMLRITGLAR
                     LLPPRATLDEVLGLTRPAGRRTGH"
     misc_feature    4290..4305
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.13"
                     /tool="antismash"
     gene            complement(4327..5277)
                     /locus_tag="SAM23877_RS31995"
                     /old_locus_tag="SAM23877_6740"
     CDS             complement(4327..5277)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (23-313). E-value: 2.5e-59.
                     Score: 192.9. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS31995_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979474.1"
                     /locus_tag="SAM23877_RS31995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6740"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_053140778.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-09, bitscore: 36.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-19, bitscore:
                     68.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDVNTMRAISQEVLGGPEVLKEVRAERPEPRPNEVLVRVRAAGV
                     NPTDWKHRANGGFLGEPPFVLGWDVSGVVEAVGIGVAAFRPGDEVFGMLSYPFGHGSHA
                     EYVTAPARAFVPLPAGVDHVQAGALPLVSLTAWQALVERADVRPGQRVLIHAAAGGVGH
                     AAVQIAKARGAHVIGTASAAKHEFLRSLGADETVDYRETDFAEVVKDVDVVLDTIGGDT
                     SLRSLRVLRPGGIVVSILPVGSDDFFEEAERLGVRAVRMLVDADRADMREIAGLVESGK
                     LRATIARTFPLADAAEAHALGETGRTTGKIVLVVD"
     aSDomain        complement(4339..5208)
                     /ASF="ER domain putatively catalyzing 2R-configuration
                     product formation"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS31995_PKS_ER.1"
                     /evalue="2.50E-59"
                     /label="SAM23877_RS31995_PKS_ER.1"
                     /locus_tag="SAM23877_RS31995"
                     /protein_end="313"
                     /protein_start="23"
                     /score="192.9"
                     /tool="antismash"
                     /translation="VRAERPEPRPNEVLVRVRAAGVNPTDWKHRANGGFLGEPPFVLGW
                     DVSGVVEAVGIGVAAFRPGDEVFGMLSYPFGHGSHAEYVTAPARAFVPLPAGVDHVQAG
                     ALPLVSLTAWQALVERADVRPGQRVLIHAAAGGVGHAAVQIAKARGAHVIGTASAAKHE
                     FLRSLGADETVDYRETDFAEVVKDVDVVLDTIGGDTSLRSLRVLRPGGIVVSILPVGSD
                     DFFEEAERLGVRAVRMLVDADRADMREIAGLVESGKLRATIARTFPLADAAEAHALGET
                     GRTTGKIVL"
     CDS_motif       complement(4771..4833)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAM23877_RS31995_0001"
                     /evalue="2.00E-09"
                     /label="PKSI-ER_m5"
                     /locus_tag="SAM23877_RS31995"
                     /protein_end="169"
                     /protein_start="148"
                     /score="29.7"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHAAVQIA"
     misc_feature    5375..5384
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     gene            5523..7304
                     /locus_tag="SAM23877_RS32000"
                     /old_locus_tag="SAM23877_6741"
     CDS             5523..7304
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327712.1"
                     /locus_tag="SAM23877_RS32000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6741"
                     /product="ATP-binding protein"
                     /protein_id="WP_053140781.1"
                     /transl_table=11
                     /translation="MELATPPPAARAPVAWYSWWLMPLGLGGGTVAATFMSSERITAAV
                     AGVVATAAGTVCVRLLLRGRAQLRRAEHVHRAAQAEHAQRWQQHVAGLERSFSAERAAL
                     EAQLSEQAQSHEARLTEHTRACEDRLAEQAATYQTRLAERTEAWQEQLGHQLAAVSRLA
                     DEQLPDAMRRLRAGDAIDDILPTVEQCAKVGAELQAELRKVLRTALIGVEAEFDRSTSA
                     EQAVIGVGNRIHVLTSKLRGRLHELQGEHGRLPAVARGLMELDQAIGPADCLAASIGVL
                     GGSDRPGRQWQEPQRLLSVVRGGIGRIKDFHRVELRHLPELGVDGGLVDHLTLVFAHLL
                     DNAARYSPPTEPVVVSGKEVPNGVGIEIQDSGKGLSEEKKREAEHALAGTSPGPGLGGI
                     SEDANIGLRVVGALARRYGIRVTFADSPWLGTSVVVVVPHKYFSPLPAAATGGAAAPET
                     GPAGGAPHAGVAPAPVASPSGAAPALRPAPGRAGDDPAETTPGGLPRRRSRREEPAAGA
                     APAPGAAAYAGRTDPAGRAPVAAVPPDASFAGLAAFATAGREGGAATGAVPPAEAAGVP
                     DPITGGASTGHRTEESD"
     gene            7310..7720
                     /locus_tag="SAM23877_RS32005"
                     /old_locus_tag="SAM23877_6742"
     CDS             7310..7720
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057749.1"
                     /locus_tag="SAM23877_RS32005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6742"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_019327713.1"
                     /transl_table=11
                     /translation="MTHQGTDVSWALRDLVESIQEIRFALVASSDGKAITSYGAEDPDD
                     VDRFAAVVAGLQALAQPVAEQFPQHAGQLRLAMIEVDGGHLFVVRAGLETYLGVLAREG
                     LDQGLLGHQMRDLARRMGELLGTTPRQEEHSG"
     gene            7717..8088
                     /locus_tag="SAM23877_RS32010"
                     /old_locus_tag="SAM23877_6743"
     CDS             7717..8088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995719.1"
                     /locus_tag="SAM23877_RS32010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6743"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_053140784.1"
                     /transl_table=11
                     /translation="MSAPRRPTDPSGLERYYVLTGGRSGPGGSASTLDVATLVVSRAVP
                     LPGMQHEHEEILRRCREPLSVAELGAHLHLPFNILAVLLSDLLQAGRVEARDPIPAHDA
                     GRGPDLALLEEVLSGLERL"
     misc_feature    7852..7854
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8069..8674
                     /locus_tag="SAM23877_RS32015"
                     /old_locus_tag="SAM23877_6744"
     CDS             8069..8674
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156547.1"
                     /locus_tag="SAM23877_RS32015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6744"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_053140786.1"
                     /transl_table=11
                     /translation="MDLKGFDRPGSPTAGETRSVKVMIAGGFGTGKTTMVRSVSDIKPL
                     TTEETLTQASAGVDHLIGVADKTETTVSLDFGKISLNDTLMLYLFGTPGQERFWFLWNG
                     LFKGALGAVVLVDTRRLASSFRAIEEMERQRVPFVIALNVFPDSRHHPVEEIRDALDIP
                     PHTPVVAFDARDRAASRDVLVTLIRHLKDRSAAALEPR"
     gene            8671..9918
                     /locus_tag="SAM23877_RS32020"
                     /old_locus_tag="SAM23877_6745"
     CDS             8671..9918
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327716.1"
                     /locus_tag="SAM23877_RS32020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6745"
                     /product="cytochrome P450"
                     /protein_id="WP_053140789.1"
                     /sec_met_domain="p450 (E-value: 1.3e-07, bitscore: 29.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDDQTPSGPTGGGCPVAHAGGVTRLYGPEAATDPHDIYARLRKE
                     YGSVAPVLLEGDVPAWLVLGYRENRRVLDNPLQFSRDSRIWRDFRDGRVEATSPLIQMV
                     GWRPDCVSQDGEPHRRLRGAVTDNLYAVAGRGIRRHVTHFANKQIDAFADTGRADLVAD
                     FAEYLPMLVLTRVFGLAEREGRNLAESSKQVIKGGADALTHNERIMGILGELAARKRQE
                     PGSDFTSGLIEHRAGLDEDEIVNHLRLVLITAHTTTSNLLARTLQMVLTETSWLSGLVS
                     GQLNLSAVVEEVMWNSPPLAVLPGRFATADLELGGRPVKKGDLLVLGLAAGNHDPEVRP
                     DIAAPVHGNASHLAFSAGPHECPGQNIGQAIIETAVDVLLHRLSGLRLAVPPAGLTSTA
                     STWESRLDSLPVEFTV"
     gene            complement(10001..11032)
                     /locus_tag="SAM23877_RS32025"
                     /old_locus_tag="SAM23877_6746"
     CDS             complement(10001..11032)
                     /EC_number="4.2.3.169"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040594.1"
                     /locus_tag="SAM23877_RS32025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6746"
                     /product="7-epi-alpha-eudesmol synthase"
                     /protein_id="WP_053140791.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-68, bitscore: 231.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQDVRFDLPFDTPVSPHLAHARDRHLRWVRERGLVRSRIGFEEY
                     RSWDLAQAAARTYPHASADDMVVLMNWFSLAFLFDDQFDAGRPDRAERIAEVARELIAT
                     PLRPAGTPPRVECPITLAWAEVWERLSDGMSLTWISRFAASWGRFLVAHCEEVDLAADG
                     RAGTLGIDDYAVFRRRTVGIHHSIDAGERSRRFEVPAAAMAHPLMERLRDLAADTIGFM
                     NDIHSFERERRRGDGHNLIAVLHRERGCSWQEAADEAYRMTTARLDEYVALESRVPLMC
                     DELGLDADERARVAMGVEAIQHWINGNYEWALTTGRYAAAKEGPVATAELAGRGSVDDL
                     LTV"
     misc_feature    complement(11458..11468)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            11463..11858
                     /locus_tag="SAM23877_RS32030"
                     /old_locus_tag="SAM23877_6747"
     CDS             11463..11858
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978082.1"
                     /locus_tag="SAM23877_RS32030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6747"
                     /product="VOC family protein"
                     /protein_id="WP_053140794.1"
                     /transl_table=11
                     /translation="MALVNAGVVVLDCAEPERLAEFYKELLGAEETEASANRIEIQGAG
                     GFRMAFRRDVNATPPSWPRPENSLQAHLDFVVEDLDEAERGVVGLGGRPLEAKDAAGPH
                     EERGFSDPAGHSFTMRRGIAPTAPKQG"
     gene            complement(11907..12209)
                     /locus_tag="SAM23877_RS32035"
                     /old_locus_tag="SAM23877_6748"
     CDS             complement(11907..12209)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676628.1"
                     /locus_tag="SAM23877_RS32035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6748"
                     /product="DUF4235 domain-containing protein"
                     /protein_id="WP_053140797.1"
                     /transl_table=11
                     /translation="MGKKKKKTLPLAYKPVGFVLGWAGGALAGMAFQKTWKVLRHEDDA
                     PDALDPDRGWGEILLAAAIQGAIFAAVRSAVDRTGAKAIERSTGVWPTDGKGGRD"
     gene            complement(12258..13283)
                     /locus_tag="SAM23877_RS32040"
                     /old_locus_tag="SAM23877_6749"
     CDS             complement(12258..13283)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978084.1"
                     /locus_tag="SAM23877_RS32040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6749"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_053140800.1"
                     /sec_met_domain="GST_C (E-value: 1.6e-06, bitscore: 27.0,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDGGTPGNSGYGRKAFKRSRSHFADRITADGRDGWPVAPGRYR
                     LVVSRACPWASRALVSRRLLGLEDALSLAVTDPLQDDRSWRFTLDPDGRDPVLGIRYLS
                     EAYDRRETGYPGGVSVPAIVDVPSGQLVTNDYQQITLDLATEWTSLHRPGAPDLYPDAL
                     RDEIDEVMAGVYEDVNNGVYRAGFATGQEEYEAACAGVFRRLEALTPRLERQRYLVGDT
                     ITEADIRLFTTLVRFDAVYHGHFKCNRWKLTENPVLWAYVRDLFQTPGFGDTVDFDHIK
                     RHYYQVHTGINPTAIVPLGPDLSGWLTPHHRQELGGRPFGDGTPPEPVRADEAVPAPGR
                     P"
     gene            13532..14449
                     /locus_tag="SAM23877_RS32045"
                     /old_locus_tag="SAM23877_6750"
     CDS             13532..14449
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040579.1"
                     /locus_tag="SAM23877_RS32045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6750"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_053143072.1"
                     /transl_table=11
                     /translation="MVALAANLVIAAAKAVGGLVAGSPALLSEAAHSVADSMNEVFLLA
                     ALRRSRRPADRRHPFGYGKERFFWSLLAAVGIFVMGGCFSFYQGVEALRTGAQEELGGY
                     VAGLIVLGVALLAEGASLLRALYQVRGQGGLATGLRDPALRTVVAEDGTAVLGVTLAMT
                     GMILHMVTGQVVWEACASLAIGALLVYVAYRLGREARDQLIGEAADPEASGRIRSLLQA
                     QPEIDSVEALFTMKTGLDSTLVAARIDLVPGLDSERVEEVAVRIKRSIARTVPEARQIF
                     LDVTDRLAEEAAESPAATGERGGA"
     gene            complement(14517..14966)
                     /locus_tag="SAM23877_RS32050"
                     /old_locus_tag="SAM23877_6751"
     CDS             complement(14517..14966)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117132.1"
                     /locus_tag="SAM23877_RS32050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6751"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_053140803.1"
                     /transl_table=11
                     /translation="MPLDGEYEPSPTQWVREQVELYESSGGTRGTTLMDTGMPVIVLTT
                     RGARSGKIRKTPLMRVEHEGRYAVVASLGGAPKHPVWYHNIKSDPHVELQDGPVKRDMT
                     AREVTGTEKAEWWERAVAAYPPYADYQKKTDREIPVFVLDPSDGS"
     gene            15162..15602
                     /locus_tag="SAM23877_RS32055"
                     /old_locus_tag="SAM23877_6752"
     CDS             15162..15602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961175.1"
                     /locus_tag="SAM23877_RS32055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6752"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_053140806.1"
                     /transl_table=11
                     /translation="MTTATGDGTTTRATVEELLRRIGQGDPDRIAELYDESADWRLSWP
                     EDEHGRAATPWIRHRRTRADAADHYRRLAAHHVPDRADTRIERILVDGEDAVVLGEIRQ
                     TAATTGRPYRATFALHLTVRDGLVVRHHVYEDSLAVARAFTP"
     gene            15836..16036
                     /locus_tag="SAM23877_RS32060"
                     /old_locus_tag="SAM23877_6753"
     CDS             15836..16036
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027347.1"
                     /locus_tag="SAM23877_RS32060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6753"
                     /product="ferredoxin"
                     /protein_id="WP_053140810.1"
                     /transl_table=11
                     /translation="MRIGIDKDTCIGAGQCALTAPDVFTQDDDGYSEVLPGREDGGGSP
                     LVREAARACPVGAISVPRTVG"
     gene            complement(16011..16619)
                     /locus_tag="SAM23877_RS32065"
                     /old_locus_tag="SAM23877_6754"
     CDS             complement(16011..16619)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983481.1"
                     /locus_tag="SAM23877_RS32065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6754"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_053140814.1"
                     /transl_table=11
                     /translation="MDDEAARERALDAAERLFYARGVQAVGMDDVRGDSGVSLKRLYRL
                     FPAKEQLVVAYLERRDVRWRGRLAEYVDRHGEPGPRILAVFDWLGQWFAEPGFRGCAWI
                     NAYGELGATSAPVTDRVRAHKEAFRAFLDRLATEAGLPTAVGGQLFLLAEGAMVSAGVS
                     GGTEPARQAREAARILLAAAGAQAATTAPSGISPPSAGR"
     misc_feature    complement(16688..16701)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.54"
                     /tool="antismash"
     misc_feature    16724..16737
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.54"
                     /tool="antismash"
     gene            16763..17197
                     /locus_tag="SAM23877_RS32070"
                     /old_locus_tag="SAM23877_6755"
     CDS             16763..17197
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978090.1"
                     /locus_tag="SAM23877_RS32070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6755"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_053140817.1"
                     /transl_table=11
                     /translation="MTTDRPPLPPFTRETAARKVRAAEDAWNTRDPHRVALAYSEDSVW
                     RNRDTFLTGRPAIVEFLTAKWARERAYALRKDLWAFDGNRIAVRFQYESHDADGQWWRS
                     YGNELWEFDEHGLMTRREASINDVAIEESDRRIHGPRPVQ"
     gene            17207..17749
                     /locus_tag="SAM23877_RS32075"
                     /old_locus_tag="SAM23877_6756"
     CDS             17207..17749
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027345.1"
                     /locus_tag="SAM23877_RS32075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6756"
                     /product="flavoprotein"
                     /protein_id="WP_053140820.1"
                     /sec_met_domain="Flavoprotein (E-value: 7.9e-12, bitscore:
                     43.9, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEQAGSARKPFLYVVVCAAGVASDVTELIAAAQRRGWEVGVFAT
                     PVAMDGFFDTAAVEERTGRPIRSAWRRPGDPRPFPAPDAVVVAPATFNTVNKWAAGLAD
                     TLAVATLCEACGLGVPVAVLPCVADALASHPAYRESLARLRGMGVRFGDPRGGEATPGG
                     GRPDFAWERALDLLEPR"
     gene            17828..18796
                     /locus_tag="SAM23877_RS32080"
                     /old_locus_tag="SAM23877_6757"
     CDS             17828..18796
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978092.1"
                     /locus_tag="SAM23877_RS32080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6757"
                     /product="aldo/keto reductase"
                     /protein_id="WP_053140823.1"
                     /transl_table=11
                     /translation="MRYVKLGSTGLDVSRICLGCMTYGVPDRGTHEWTLDEEASRPLIR
                     QALDAGINFFDTANVYSDGTSEEIVGKALRDFARRDDIVLATKVHGTMRPGPNGGGLSR
                     KAIMTEIDHSLRRLGTDYVDLYQIHRFDPHTPVEETMEALHDLVKAGKARYLGASSMYA
                     WQFSKMQYTAERHGWTKFVSMQNHYNLLYREEEREMLPLCADQGVGVLPWSPLARGRLT
                     RDWDTATERSATDNFGSTLYQEGDRAVVDAVTRIAGDRGVPRAQVALAWLLHRSTVTAP
                     IIGASKSRHLEDAVAAVELTLTEKEAEELERPYAPHPIAGH"
     gene            complement(18821..19471)
                     /locus_tag="SAM23877_RS32085"
                     /old_locus_tag="SAM23877_6758"
     CDS             complement(18821..19471)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027343.1"
                     /locus_tag="SAM23877_RS32085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6758"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_053140825.1"
                     /transl_table=11
                     /translation="MPNTSQPLCRTALLASALAVLGVLTACGSESGTPSASTPRATEAP
                     STPGPDSGAATAPADGTTPSDTAGSASASARTDGRCHTSELRAAVGRVDPGAGQRNFPV
                     VLTNTSDRTCTVYGYPGAAFVDASGEQLGPDPDRAPSSPVTLTLTPGKSAWAGLSFSSP
                     QISGARTATPAALLVTPPDERDPIEVAWTAGEVPVGGDESSVSVTALEAGTGP"
     misc_feature    complement(20542..20556)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(20992..21007)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.83"
                     /tool="antismash"
ORIGIN
        1 ccatgccggg ccgtcgcacc gcggccggac gagggctcag gacccgtagg tcacccgtac
       61 cttctcgaaa ccgagggagc gcagcaggcc ctggagcatc gccgtggtgt tggtctcggc
      121 gcgcgccgtg agctcgctgt ccttcgccgc gtcgccgatg tgccgggccg cgagcttctg
      181 cacggcctgt tcaccgttcg ggttgtccga gaacaggtcg cccaggcggt cgaggagccc
      241 gcgctgcttg gagacggcgt aggagcggtc ggggtcgagg gccggctcac cgagcgccgc
      301 gtgcggcagc cgcagcgtgg ccgaggtgcg gtcgtcgtcg accgtcacgt cgtcatcgcc
      361 caccttcccg aggtcgacgt aggcgtcgac ggtgcccgcc ccgacgtaca gggtgcggct
      421 gccgcggatc gcatcgggca ggaacttggt gtccttctcc aggtccacga cgacctggaa
      481 gttcccggac gcggcctcgt agcggctcat gtcctggatg gactccagca gcgccggacc
      541 cgagcggtcc tgggtctcgg tgccgaacag gtccttgagt cccggtacga cgctcagccg
      601 cagtccggcg aagagcacgg cgagcaccag cacgatcgcg ctcagcacct tcgcccagcc
      661 gggcacgcgc cggggcaggt tcctgatggg agtcgtcatg gcggcggccc tccttcctac
      721 tgaccggatg ccctccatct ccccgcgcag accggtcagt tggcggcgcc ggtcagcggc
      781 ggcgggggag gggaggggag cgcgaccacc gcacctcagc gcggtggatc cagcggacgg
      841 tccccggacg gccgggacga ccacaccgcc tccccgcgag tgaggccggg caggcccagt
      901 tccgcctccc gcacccgccg ggccggcagc tcgccggtga tcagccagcc ggagccgccg
      961 cccgtcgtgc cggtgaactc cgcgcccagc gaggcgagcc gggccgtcac gggcgccagc
     1021 gcgtcgggtg gcacctccgc ctcgaaggcg tggagcggct cgtggagccg ggtcccggcc
     1081 cgccccaggg cccggcgcag cacgatcggg gtcagtccgc ggaagtcggc ggcggtgctg
     1141 accggcgagc tgaatccgga gcgggtcagc gtgacccggt agtcggtgac cggggccccg
     1201 gtcagaccgg tcagcagggt ggcgtggacc gtctcctcga cggcctggtg gaaggcgcgg
     1261 gggagggcgc cgagttccgt ctcgtgggcg aacacaccgc ccgagccgcg cgggcccggc
     1321 tcgacgcgca gcccgacggt cgcccagtac cgggtgcggt cgagccacgg catctcctcc
     1381 gcggcctccc cggtgccggc cgggcgctcc agaaaccggg cgcggcccgg ggcgaagtcc
     1441 gcctcgatgc cgaagtcctc ggacagcgtc gccgccagca cctccatctg gacctctccg
     1501 tacaggagca gcgccgtggc gcccgacgcc gccgggcggg cgtgcagcag cgggtcctgg
     1561 tcggcgaggt ccagcagggc ggcccgcagc ggccccgcct gcccggggtg ccgggcccgg
     1621 accagggtct ccagcgtcgg cggcgcgaac tgcggggccc ggtcggtccg agcgccgagc
     1681 cggtcgccga cgcgcagccc gccgggcacg gtgagggccg cgatgttgcc ggcggtgagc
     1741 gtcccggggc ggccgatcac gtcgaggcgg gtcacccgcc cggtgacctc ggtggtccgt
     1801 ccgtcggact cgcgccgcag gaacgtgagc cgttggcgcg ggcgcacctc cccggcgtgg
     1861 agccgcaggt acgccgtccg ctcaccgccg gatgcggggc gcagggcgaa gacggtgccg
     1921 cgcggcgccg cggggccggc cgccggggga gaggcgggcg ggaccagccg gagcagactc
     1981 tccaccagtt ccgcgacgcc ctgcccaccg agggcggagc cgtggtgcag cgggtggaag
     2041 gagccgtcgg cggtgcgggc cgcgagcgcg gcggccagtt ccccggcggt cggttcggga
     2101 ccgtccacca gcgcggccag gatgcccggg tcgacctcgg cgagcgcctc ggcggtccgc
     2161 ccgtccggcg ttcggcgggt gacgcgggcg tgcccggtgc cggcgcctgt gacctcggtc
     2221 aacggtgcga cgtgcggcgt cagcaggcgc cggacgtcgg cgagcagctc ctcggtgcgc
     2281 gcaccggccc ggtcgatctt gttgacgaag acgagcgtgg gcagccgcag ccgccgcagc
     2341 gtgcgcatca gcacacgggt gcgggcctgg acgccctcca ccgcggagag cagcagcacc
     2401 gcgccgtcga ggacctccag ggcacgctcc acctcggcga cgaagtcgga gtgtcccggc
     2461 gtgtcgatca gattgacctg ggtgtcgccg acggtgaagg cggcgacggc ggagcggatg
     2521 gtgatgccgc ggcggcgctc gatcccgccg tcgtccgtgc gggtgtcacc cgcgtcgacg
     2581 ctgccgagcc ggtcgatggc gccgtgatcg aagaggagcc gctcggtgag actggtctta
     2641 ccggcgtcga cgtgggccag gatgccgatg ttcagggtgt tcggaatgtg catgcgctgt
     2701 cgagtcctcg aaaaccgtgg gccggaaggg gcactgggtg attccgagga gtcggcgcat
     2761 gcgggggatc ctgacctgag gggagacggg cggttccatc atggcgccgg cccccggggc
     2821 cgccgcaacc ggatatccgt aagctgaggc tcccggccgg acagcgtccg gacaggatca
     2881 cgcgaggagc ggtccgtgcg agacatcgcc gtgttcagcg gtagtgccca ccccgagctg
     2941 gccgaggagg tctgcgcgca cctgggcgtg cccctcagcc ccacccgggt gagccgcttc
     3001 gccaacgact gtctggaggt gcagctgcgg gccaactgcc gcgaacggga cgtcttcctg
     3061 gtccagccac tggtcaagcc ggtgcaggag cacctcgtcg agctgctgct gatgtgcgac
     3121 gcggcccgcg gggcgtcggc cggacgcatc accgtcgtga tgccgcacta ctcctacgcc
     3181 cgctccgaca agaaggacgc gccgcgcatc tcgctcggcg gacgcctcgt ggcggacctg
     3241 ctggtggcgg cgggcgcgag ccgggtgctg gccatgaccc tgcactcgcc ccaggtgcac
     3301 ggcttcttct cggtcccggt cgaccacctg cacgcgctgc gtgaactggc cgcgcacttc
     3361 cggcagtacg acctgtcccg caccacggtc gtctcgccgg acctcggcaa cgccaaggag
     3421 gccgccgcgt tcgcccggat gctcggcgcc caggtcgcgg ccggcgccaa gcagcgctac
     3481 gccgacgacc gggtcagcat cagcgccgtg atcggtgagg tcgccgggcg cgacgtcatc
     3541 gtcctcgacg acgagatcgc caagggcagc acggtcctcg aactcctgga ccggctgcgg
     3601 gaggcggggc cgcgcaccat ccgtctcgcc tgcacgcacg ggctgttcgc gtccggcgcc
     3661 ctcaaacggc tcagtgatca gccggacgtg ctggagatcg tgtgcaccaa caccgtgccg
     3721 gtgccggccg acgaccacac ggagaagctg cgcgtcctgt cgatcgcccc cgcactggcc
     3781 gaggccgtgc gccgcatcca caacggtgag tcggtcagtg ccctgttcga cgccccgccg
     3841 ggcgggtgag gccgagcacc tcgtccaggg tggcccgcgg tggcagcagc cgcgccaggc
     3901 cggtgatccg cagcatgcgc agggtcagcg ggtgggtgca cacgaggtgc acctgcccgc
     3961 cgtggtcgag cacctggcgc cgggcccggt acagcaggcg caggccggag cagtcgaaga
     4021 actcgacccc ggagaggtcg agcacgaccc gggcgccggg gcggcccgcc tcccgctcca
     4081 ggcgcggggc gatctccgcg gccgacgcga tgtcgatctc gccccggagc tccagcaccg
     4141 tgtgcccgtg ttcctggcgc acgtgcagat gcccggtggg cgacgcgggt tcgtaccgca
     4201 cggcgaccat gcctccagcc tgttccggtg gctcaactga tgaccccgcc cgggaagtta
     4261 ccccgatcga gcgattttga gcatgttcga ttgacatatg tcatcgaaat ttgccaagcg
     4321 gttcgatcag tcgaccacga ggacgatctt gcccgtggtg cggccggtct cacccagcgc
     4381 gtgcgcctcg gccgcgtcgg ccagcgggaa cgtccgcgcg atcgtggccc gcagcttccc
     4441 cgactcgacc aggccggcga tctcccgcat gtcggcccgg tcggcgtcca cgagcatccg
     4501 gaccgcccgc acgccgagcc gctcggcctc ctcgaagaag tcgtccgaac cgaccggcag
     4561 gatcgacacc acgatcccgc ccggacgcag cacgcgcagc gaacgcaggg acgtgtcacc
     4621 gccgatcgtg tccaggacga cgtccacgtc cttcacgacc tcggcgaagt cggtctcccg
     4681 gtagtccacc gtctcgtccg ccccgaggga gcgcaggaac tcgtgcttgg ccgcgctggc
     4741 ggtaccgatc acatgggcac cccgcgcctt ggcgatctgc accgccgcat gtcccacccc
     4801 gccggctgcc gcgtggatca gcacccgctg tcccggccgg acgtccgccc gctccaccag
     4861 ggcctgccag gccgtcagcg agaccagcgg gagcgcgccg gcctggacgt ggtcgacccc
     4921 ggccggcagg ggcacgaagg cgcgcgcggg agccgtcacg tactccgcgt gggagccgtg
     4981 gccgaacgga taggagagca tgccgaagac ctcgtcgccg ggccggaacg cggcgacgcc
     5041 gatccccacc gcctccacca cgcccgagac gtcccagccc agcacgaagg gcggttcgcc
     5101 gaggaaccct ccgttcgccc ggtgcttcca gtcggtcggg ttcaccccgg cggcgcgcac
     5161 gcgcaccagg acctcgttcg ggcggggctc ggggcgctcg gcccgtactt ccttcaggac
     5221 ctcgggaccg ccgaggacct cctggctgat ggctcgcatg gtgttcacgt cgctcatggt
     5281 cacccagctt gcctcgctcc gccacgtcgg gggaaccgcg cgttcgcctc ctgtcggagg
     5341 gtgacggaat cctcacttcc gccgggctcc ggattgatct tttaggcttc ccaaccgata
     5401 agctccctga cggcgctgcg agttgacacg gccgcgacgg gtcggctcgc ggtgcgtact
     5461 catgagtgcg gtccccttgc acaccccccc cgtgttcgat cgttctggtt cgaaggatgc
     5521 agatggaact cgccactccg ccaccggcgg cgcgggcccc tgtcgcctgg tacagctggt
     5581 ggctgatgcc actgggcctg ggcggcggga cggtagccgc cacgttcatg agctcggagc
     5641 gaataaccgc ggccgtcgcc ggtgtggtgg cgacggcggc gggcaccgtg tgcgtacgcc
     5701 tcctcctgcg tggtcgcgcg cagctgcgcc gggccgagca cgtccaccgt gccgcgcagg
     5761 ccgagcacgc gcagcggtgg cagcagcacg tggccggcct ggagcggagc ttctccgccg
     5821 agcgtgccgc cctggaggca cagctctccg aacaggcaca gagccacgag gcacgtctga
     5881 cggagcacac ccgcgcctgc gaggaccggc tggccgagca ggccgcgacg taccagaccc
     5941 gcctcgccga gcggaccgag gcctggcagg agcagctcgg gcaccagctg gccgcggtgt
     6001 cccggctcgc cgacgagcag ctgcccgacg ccatgcgcag gctgcgcgcc ggtgacgcga
     6061 tcgacgacat cctgcccacc gtcgagcagt gcgcgaaggt cggcgccgag ctccaggccg
     6121 agctgcgcaa ggtcctcagg accgcgctga tcggcgtcga ggcggagttc gaccgttcga
     6181 cctccgccga acaggccgtc atcggcgtgg gcaaccgcat ccacgtgctg accagcaagc
     6241 tccgcggccg tctgcacgag ctgcagggcg agcacggacg gctgccggcc gtcgcccggg
     6301 ggctgatgga actcgaccag gccatcggcc ccgccgactg tctcgccgcc agcatcggtg
     6361 tgctcggcgg ctccgaccgc ccgggccggc agtggcagga gccgcaacgc ctgctgagcg
     6421 tggtgcgggg cggcatcggc cggatcaagg acttccaccg cgtcgagctg cgccatctgc
     6481 ccgagctcgg cgtggacggc ggcctggtgg accacctcac gctggtcttc gcccacctgc
     6541 tggacaacgc cgcgcgctac tcgccgccca ccgaaccggt cgtcgtctcc ggcaaggagg
     6601 tccccaacgg cgtcggcatc gagatccagg attccggcaa ggggctcagc gaggagaaga
     6661 agcgcgaggc cgagcacgcc ctggcgggca cctcgcccgg cccggggctc ggtggcatct
     6721 cggaggacgc caacatcggc ctgcgcgtcg tgggagccct cgcccgtcgc tacggcattc
     6781 gcgtgacctt cgcggactcg ccatggctgg ggacgtctgt cgtagtcgtt gtaccgcaca
     6841 agtacttcag cccgctgccg gccgccgcca ccggcggcgc cgccgcgccg gagaccgggc
     6901 cggccggcgg cgcaccgcac gccggagtgg caccggcccc cgtcgcgtca ccgtccggcg
     6961 cggcaccggc tctccggccg gcccccggcc gagccggcga cgaccccgcc gagacgaccc
     7021 ccggcggcct gcccaggcgc aggagcaggc gtgaagagcc ggccgccggt gcggccccgg
     7081 cccccggggc cgccgcgtac gccggccgga ccgacccggc cggtcgggcc cccgtagccg
     7141 ccgttccgcc ggacgcctcc ttcgccggtc tcgccgcctt cgccaccgcc ggacgcgaag
     7201 gcggcgcggc gaccggcgcg gtcccacccg ccgaagccgc cggcgtcccc gacccgatca
     7261 ccggtggcgc gtccaccggg caccgcactg aagagagcga ctagtcccca tgacgcacca
     7321 gggaaccgac gtgagctggg cgctccgcga ccttgtggag agcatccagg agatccgctt
     7381 cgccctcgtc gcctccagcg acggcaaggc catcacctcc tacggcgccg aagaccccga
     7441 cgacgtggac cgcttcgccg ccgtggtggc cggactgcag gcgctggccc agcccgtcgc
     7501 ggagcagttc ccccagcacg cggggcagtt gcggctggcg atgatcgaag tggacggcgg
     7561 gcacctcttc gtcgtccgcg cgggcctgga gacgtatctg ggcgtgctcg cccgcgaggg
     7621 cctcgaccag ggtctgctgg gccatcagat gcgcgacctg gcccgcagga tgggtgaact
     7681 cctcggcacc accccgcgcc aggaggagca ctctggatga gtgctccccg ccggccgacc
     7741 gatccgtccg gtctcgagcg ctactacgtc ctcaccggag ggcgcagcgg accgggcggt
     7801 tcggcgtcga ccctcgacgt ggcgaccctc gtcgtctccc gggccgtccc cttaccgggc
     7861 atgcagcacg agcacgagga gatcctccgg cgctgccgcg aaccgctgtc ggtggccgag
     7921 ctcggcgccc acctccacct gcccttcaac attctcgcgg tgctgctgtc cgacctgctc
     7981 caggcgggcc gcgtcgaagc ccgtgatccc atcccggcgc acgacgccgg ccgcgggccc
     8041 gacctcgcgc tccttgagga ggtactcagt ggacttgaaa ggctttgacc gaccggggtc
     8101 gccgacggcc ggggagaccc gctcggtgaa ggtgatgatc gccggcggct tcggcaccgg
     8161 caagaccacc atggtccggt ccgtcagcga catcaaaccg ctgaccacgg aggagacgct
     8221 cacccaggcc agcgccggcg tcgaccacct catcggtgtc gcggacaaga ccgagaccac
     8281 cgtcagcctg gacttcggca agatcagcct caacgacacg ctgatgctgt acctgttcgg
     8341 caccccgggg caggagaggt tctggttcct gtggaacggc ctcttcaaag gcgccctcgg
     8401 cgcggtcgtc ctggtggaca cccggcggct ggcctccagt ttccgggcga tcgaggagat
     8461 ggagcggcag cgggtcccct tcgtcatcgc gctcaacgtc ttccccgact cccggcacca
     8521 cccggtcgag gagatccgcg acgccctgga catcccgccg cacacaccgg tcgtcgcctt
     8581 cgacgcccgg gaccgcgccg ccagccggga tgtgctggtc acgctgatac ggcatctgaa
     8641 ggaccgctcg gcggccgccc tggagccccg atgaacgacg accagacccc gtccggcccc
     8701 accggcggcg gctgccccgt cgcccacgca gggggcgtca cccggctcta cggccccgag
     8761 gcggcgaccg acccgcacga catctacgcc cgcctgcgca aggagtacgg atcggtcgcc
     8821 ccggtgctcc tggagggtga cgtgcccgcc tggctggtgc tcgggtaccg ggagaaccgg
     8881 cgagtgctgg acaaccccct ccagttcagc cgcgactcgc ggatctggcg ggacttccgg
     8941 gacggccgcg tcgaggcgac gtcccccctg atccagatgg tgggctggcg tcccgactgc
     9001 gtctcccagg acggcgagcc gcaccgccgg ctgcgcgggg cggtcaccga caacctgtac
     9061 gccgtggccg gccggggcat ccggcggcac gtcacgcact tcgcgaacaa gcagatcgac
     9121 gcgttcgccg acacgggccg cgcggacctg gtggccgact tcgccgagta cctgcccatg
     9181 ctcgtactca cccgggtctt cggactcgcc gagcgggagg ggcggaacct cgccgagtcc
     9241 agcaagcagg tgatcaaggg cggagcggac gccctcacgc acaacgagcg catcatgggc
     9301 atcctcggcg aactcgccgc gcgcaagcgg caggagccgg gctccgactt cacctccggt
     9361 ctcatcgagc accgcgccgg actcgacgag gacgagatcg tcaaccacct gcgcctggtg
     9421 ctgatcaccg cccacaccac gaccagcaac ctgctggccc gaacgctcca gatggttctc
     9481 accgagacct cctggctgtc cggtctggtg agcgggcagc tgaacctgtc cgcggtcgtg
     9541 gaggaggtga tgtggaactc cccgccgctg gcggtgctgc cgggccggtt cgccacggcc
     9601 gacctggaac tcggcggccg cccggtcaag aagggcgacc tgctcgtgct gggtctggcg
     9661 gccggcaacc acgaccccga ggtccggccc gacatcgccg ccccggtgca cggcaacgcc
     9721 tcgcacctgg ccttcagcgc cggcccccac gagtgcccgg ggcagaacat cggccaggcc
     9781 atcatcgaga cggccgtcga cgtcctgctg caccggctgt ccgggctgcg cctggccgtg
     9841 ccgccggccg gcctgacgtc caccgcctcc acctgggagt cgcggctgga cagcctgccg
     9901 gtggagttca ccgtctagca cgcggcacgg tgcccgcccc gcccggccgg acgtcccggc
     9961 cgggcggtcg gctccctcac acggtcgacg gcccgctccc tcacacggtc agcaggtcgt
    10021 ccaccgagcc ccgcccggcc agctcggccg tggccaccgg accctccttg gccgccgcgt
    10081 agcggccggt ggtcaacgcc cactcgtagt tgccgttgat ccagtgctgg atggcctcca
    10141 cccccatcgc cacccgggcc cgctcgtccg cgtccagccc cagttcgtcg cacatcagcg
    10201 gcacacggct ctccagggcc acgtactcgt ccaggcgggc ggtcgtcatg cggtacgcct
    10261 cgtcggcggc ctcctgccac gagcagcccc gctcccggtg cagcacggcg atgaggttgt
    10321 ggccgtcacc gcgccggcgc tcgcgctcga aggagtggat gtcgttcatg aagccgatcg
    10381 tgtccgcggc caagtcgcgc agccgctcca tcagcggatg cgccatcgcc gcggccggca
    10441 cctcgaagcg gcggctgcgc tcgcccgcgt cgatgctgtg gtggatgccg accgtacggc
    10501 gccggaagac ggcgtagtcg tcgatgccga gggtcccggc ccggccatcg gccgccaggt
    10561 cgacctcctc gcagtgcgcc accaggaacc tgccccagga ggccgcgaac cgggatatcc
    10621 acgtcaggga catgccatcc gagaggcgtt cccagacctc cgcccaggcc agggtgatgg
    10681 ggcactcgac ccgaggcggg gtgcccgccg ggcgcagcgg cgtggcgatg agctcccgcg
    10741 ccacctccgc tatgcgctcg gcccggtccg gccggccggc gtcgaactgg tcgtcgaaga
    10801 ggaaggccag ggagaaccag ttcatcagga cgaccatgtc gtccgccgac gcgtgggggt
    10861 aggtgcgggc ggcggcctgc gccaggtccc aggaccggta ctcctcgaac ccgatccggc
    10921 tgcgtaccag tccccgctcg cgcacccagc gcaggtggcg gtcgcgggcg tgggcgagat
    10981 gcgggctgac gggggtgtcg aaggggaggt cgaagcggac gtcctgagac atgtgtttcc
    11041 tttcgggaga cgagacgcag agtccccccg cccctgcgag cggacgttcg cgagaccgtc
    11101 cgcacactcg aaccgggcct cccgatccgg aagttgaatc gagaagcgat acgaggctgc
    11161 cccgacccta aatgatctac gcggcgcccg gtcgtgatct tggttactgc tcacgccgcg
    11221 ggcgccgcgt acactcgcgc gccccccgcg tacgcccgtg ccgcccacgt cggtaccggg
    11281 ccgagccgtg ctcccggggc ctgcccgcgc gcgtgcaagt ccgacgcgcg acggacgagt
    11341 tggagggacg cggcccgaat gcgcgacggc cgtcggccga ctgattcggc cgggccggga
    11401 tatccgcaag gtacagggcg cggggcacgt acgccccgcg ccccgaatcc tccggaggag
    11461 acatggcact ggtcaacgcg ggcgtcgtgg tgctcgactg cgccgaaccc gagcggctcg
    11521 ccgagttcta caaagagctg ctgggcgcgg aagagaccga agcgagcgcc aaccggatcg
    11581 agatccaggg ggccggcggc ttccgcatgg cgttccggcg ggacgtgaac gccaccccgc
    11641 cgagctggcc ccgccccgag aactctctcc aggcccacct ggacttcgtc gtcgaggacc
    11701 tcgacgaggc cgaacgcggg gtcgtggggc tgggcgggcg tccgctggag gccaaggacg
    11761 cggccggccc gcacgaggag cggggtttct ccgatcccgc gggccactcc ttcacgatgc
    11821 gccgcggtat cgcgccgacg gcacccaagc agggctagcg cctgccgggt gccgtcggtg
    11881 aaagggggcc gggcccgggg gtccggtcag tcccggccgc cctttccgtc ggtcggccac
    11941 acgcccgtcg agcgttcgat ggccttggcg ccggtccggt ccaccgcgct gcgcaccgcg
    12001 gcgaagatgg cgccctggat cgcggcggcc agcaggatct ccccccagcc gcggtccggg
    12061 tccagcgcgt cgggcgcgtc gtcctcgtgc cggagcacct tccaggtctt ctggaaggcc
    12121 atcccggcca gcgcaccgcc cgcccagccc agcacgaagc cgacgggctt gtaggcgagg
    12181 gggagcgtct tcttcttttt cttgcccacg tgggtctcct agggttccga tgggtgcgtc
    12241 gtcggtcggt cgtacggtca gggcctgccc ggcgccggaa ccgcctcgtc ggcgcggacc
    12301 ggctccggcg gtgtcccgtc gccgaacggc cgcccgccca gctcctgccg gtgatggggt
    12361 gtgagccagc cggacaggtc cgggcccagg ggcacgatgg cggtcgggtt gatgccggtg
    12421 tgcacctggt agtagtggcg tttgatgtgg tcgaagtcga cggtgtcgcc gaagccgggc
    12481 gtctggaaca ggtcgcggac gtacgcccac agcaccgggt tctccgtcag cttccagcgg
    12541 ttgcacttga agtgaccgtg gtagacggcg tcgaaacgga cgagcgtagt gaacagccgg
    12601 atgtccgcct ccgtgatggt gtcaccgacc aggtagcgct gccgctccag ccgcggcgtc
    12661 agcgcctcca gacgccggaa gacgcccgcg cacgccgcct cgtactcctc ctggccggtc
    12721 gcgaatcccg cgcggtagac gccgttgttg acatcctcgt agacgcccgc catcacctcg
    12781 tcgatctcgt cgcgcagggc gtccgggtac aggtcgggtg cccccggccg gtgcagggac
    12841 gtccactcgg tcgcgaggtc cagggtgatc tgctggtagt cgttggtgac cagctgcccg
    12901 ctgggcacgt ccacgatcgc cggcacactc actccgcccg gatagccggt ctcccgccgg
    12961 tcgtaggcct cgctgagata gcggatgccg agtaccgggt cgcggccgtc cgggtccagg
    13021 gtgaagcgcc agctgcggtc gtcctggagg ggatcggtga ccgccaggga cagggcgtcc
    13081 tccagcccga gcagccgccg tgagacgagg gcgcggctcg cccacgggca ggcacggctc
    13141 accaccagcc ggtagcggcc gggcgccacg ggccagccgt cccggccgtc cgcggtgatc
    13201 cggtccgcga agtggctcct ggaccgcttg aaggccttcc tgccgtagcc gctgttgccc
    13261 ggcgttccgc cgtcaccgct catggccccg ccttccggtc gttcgtgtgc tctggaggac
    13321 gcgttccccg ttttcggcgg tcggcactgg tgagccaccc atcaggcggg tgtgagcccg
    13381 gccggccgag ggcagtcggg ccctcgtgac tgggacagct tcggaagaca agacggcccg
    13441 cgggaccgac cacgggaggg accgggagac cgaccacggg acggatcgcg agaccgacca
    13501 gggcgccgac cgcaggacgc gtgtcacggt tctggtcgcg ctcgcggcca acctggtgat
    13561 agccgccgcc aaggcggtgg ggggtctcgt ggcgggctcg cccgcgctgc tgtcggaggc
    13621 ggcgcactcg gtggccgaca gcatgaacga ggtcttcctg ctcgccgccc tgcgccgcag
    13681 ccgccgcccc gccgaccgcc ggcacccctt cggctacggc aaggaacggt tcttctggtc
    13741 cttgctggca gccgtcggca tcttcgtgat gggcggctgc ttctccttct accaaggggt
    13801 cgaggccctg cgcaccggcg cccaggagga gctcggcggc tacgtggccg ggctgatcgt
    13861 gctcggcgtc gccctgctcg ccgagggagc ctccctgctg cgggccctgt accaggtgcg
    13921 gggccagggc gggctcgcca ccgggctgcg cgatccggcc ctgcgcacgg tcgtcgccga
    13981 ggacggcacc gcggtgctcg gcgtgaccct cgcgatgacc ggcatgatcc tgcacatggt
    14041 caccggacag gtggtgtggg aggcctgcgc ctcgctcgcg atcggcgcgc tgctcgtgta
    14101 cgtggcgtac cggctgggcc gcgaggcccg cgaccagctg atcggcgagg ccgccgaccc
    14161 ggaggccagc ggccgcatcc ggtcgctgct gcaggcgcag ccggagatcg acagcgtcga
    14221 ggcgctgttc accatgaaga ccggactgga ctccaccctg gtggccgccc gcatcgacct
    14281 ggtgcccggc ctggacagcg agcgggtgga ggaggtcgcg gtgcgcatca agaggtcgat
    14341 cgcgcgcacc gtacccgagg cgcggcagat cttcctcgac gtcaccgacc ggctcgccga
    14401 ggaggcagcg gaaagccccg ccgcgacggg ggagcgcggc ggggcctgag gcacgcgttc
    14461 ccggcggtcg ccggaccatg cacacggctt cggagaaact tccggccgcc cggagctcag
    14521 cttccgtcgg acgggtccag gacgaacacc gggatctccc ggtccgtctt cttctggtag
    14581 tcggcgtacg gcgggtacgc cgcgacggca cgctcccacc actcggcctt ctccgtgccg
    14641 gtgacctcac gggccgtcat gtcccgcttc accgggccgt cctgcagttc cacgtgggga
    14701 tcggacttga tgttgtggta ccagaccggg tgcttgggcg ccccgcccag cgaggcgacc
    14761 acggcgtagc ggccctcgtg ctcgacgcgc atcagcgggg tcttgcggat cttgccgctc
    14821 cgcgcgcccc gcgtggtgag cacgatgacg ggcatgcccg tgtccatcag ggtcgtgccc
    14881 ctggtcccgc cggagctctc gtagagctcg acctgttcgc gcacccactg cgtcgggctg
    14941 ggttcgtatt cgccgtcaag aggcatggca tccgtcccat catcgcgtcg tacgactgac
    15001 cggcaccgcg gtggccaccg gcggtgcagc gtccatcctt accgcattcc gcccgcggac
    15061 ctcccgcggc gcaatgacct cgcgcgtcat cgcgccaacg gcggccgtgc ggcacagtcg
    15121 tcctcgtccg cacgaagacc cagccgaagg agacgccgcc gatgaccacc gccaccggag
    15181 acggtacgac cacccgcgcc acggtcgagg agctgctgcg cagaataggc cagggcgacc
    15241 cggaccggat cgccgagctg tacgacgagt cggccgactg gcggctgagt tggcccgagg
    15301 acgaacacgg ccgcgccgcc accccgtgga tccggcaccg gcgcacccgg gcggacgccg
    15361 ccgaccacta ccgccgactg gccgcgcacc atgtgccgga ccgggcggac acccggatcg
    15421 agcgcatcct ggtcgacggc gaggacgccg tggtgctcgg cgagatccgg cagaccgccg
    15481 cgaccaccgg gcggccctat cgagccacct tcgccctgca cctgacggtc cgcgacggcc
    15541 tggtcgtccg tcaccacgtg tacgaggaca gcctcgccgt ggcccgggcg ttcaccccct
    15601 agggccgccc gccggcgacg gcccgcccgg cggagttccc cggccggccg gcgcccgtca
    15661 ccgatctggc cgaacttcgc gtcgccgtgt aggtgcctgg ggcatctaat gagcaccggc
    15721 acgacgcact cttcgtctgc gaggtcttcc atgacggaca ccgacacgac gacggccggg
    15781 gacacgacgg cacccgtcgc cttcccgcag gaccggacct gcccctactc ccggcatgcg
    15841 catcggcatc gacaaggaca cctgcatcgg cgcgggccag tgcgccctga ccgccccgga
    15901 cgtgttcacc caggacgacg acggctacag cgaggtgctg cccggccggg aggacggcgg
    15961 cggcagcccg ctggtacggg aggcggcccg ggcgtgcccg gtgggcgcca tcagcgtccc
    16021 gcggacggtg ggctgatccc ggaaggggcc gtggtcgcgg cctgagcccc cgcggcggcc
    16081 agcaggatcc gtgccgcctc gcgggcctgt cgagcgggct cggtacctcc gctgacgccc
    16141 gccgagacca tggcaccctc ggccagcagg aacagctgcc cgcccaccgc ggtgggcagt
    16201 cccgcttcgg tcgccaggcg gtcgaggaac gcgcggaacg cctccttgtg cgcccgcacc
    16261 cggtccgtca ccggggcgga ggtggccccc agttcgccgt acgcgttgat ccacgcgcag
    16321 ccgcggaagc cgggctcggc gaaccactgc ccgagccagt cgaagacggc caggatccgg
    16381 gggccgggct ccccgtgccg gtcgacgtac tccgccagcc gcccccgcca gcgcacgtca
    16441 cgccgctcca gataggccac cacgagctgc tccttggccg ggaacagccg gtagaggcgc
    16501 ttgagggaga cgccggagtc gccgcggacg tcgtccatgc cgacggcctg cacgccccgc
    16561 gcgtagaaaa gtcgctccgc cgcgtccagc gcccgctcgc gggcggcctc gtcgtccatg
    16621 gtgtcctcct tccgaaaccg ctgcccgcgg tgttccccgc gcggtccggc cggtgtccct
    16681 tgacgggaga acgcacgttc tcctacggta gcagccctgg aagagaacgt gcgttctccg
    16741 ctgctccccc ggaggttgag ccatgacgac cgaccgtccg cccctgccgc cgttcacccg
    16801 cgagaccgcc gcccgcaagg tgcgggcggc cgaggacgcc tggaacaccc gggacccgca
    16861 ccgggtcgcg ctcgcctatt ccgaggactc cgtctggcgc aaccgcgaca cgttcctcac
    16921 gggccgcccg gccatcgtcg agttcctcac cgccaagtgg gcgcgcgagc gcgcgtacgc
    16981 gctgcgcaag gacctgtggg ccttcgacgg caaccgcatc gccgtccgct tccaatacga
    17041 gtcccacgac gccgacggcc agtggtggcg ctcctacggc aacgagctgt gggagttcga
    17101 cgagcacggc ctcatgaccc ggcgggaggc gagcatcaac gacgtggcca tcgaggagtc
    17161 ggaccgccgc atccacggcc cacggcccgt tcagtagggt tccggggtga gcgaacaggc
    17221 cgggagcgcc cggaaaccct tcctctacgt cgtcgtctgc gccgcgggtg tggcctcgga
    17281 cgtcaccgaa ctgatcgccg ccgcgcagcg acgcggctgg gaggtcggcg tcttcgcgac
    17341 cccggtcgcc atggacggct tcttcgacac cgccgccgtc gaggagcgga ccggccgccc
    17401 catccgctcc gcctggcgcc gccccggcga tccgcggccc ttcccggcgc cggacgccgt
    17461 cgtggtcgcg cccgccacct tcaacacggt caacaagtgg gcggccggac tggccgacac
    17521 cctggccgtg gccaccctgt gcgaggcctg cggcctgggc gtgcccgtcg ccgtactgcc
    17581 gtgcgtcgcc gacgcgctgg cgtcccaccc cgcgtaccgg gagagcctgg cacggctgcg
    17641 cgggatgggc gtgcgcttcg gcgacccccg cggcggggag gcgacgccgg gcggcgggcg
    17701 gccggacttc gcctgggaac gggcgctgga cctgctcgaa ccgcgctgac ccgcccggtc
    17761 ttcgagtccg caccaagccg tacgctcgcg actgtcactg atgatcccga agacaggagc
    17821 agcaacgatg cggtacgtga agctcggttc gacgggcctg gacgtctcgc ggatctgcct
    17881 gggctgcatg acctacggtg tgcccgaccg cggcacacac gagtggaccc tcgacgagga
    17941 ggcctcgcgt ccgctgatcc ggcaggccct ggacgccggc atcaacttct tcgacacggc
    18001 caacgtctac tcggacggca ccagcgagga gatcgtcggc aaggcgctgc gcgacttcgc
    18061 ccgccgcgac gacatcgtgc tcgcgaccaa ggtgcacggc acgatgcggc ccggccccaa
    18121 cggcggcgga ctgtcccgca aggcgatcat gaccgagatc gaccacagcc tgcggcgcct
    18181 gggcaccgac tacgtcgacc tctaccagat ccaccgtttc gacccgcaca ccccggtcga
    18241 ggagacgatg gaagcgctgc acgacctggt gaaggcgggc aaggcccgct acctcggggc
    18301 cagttcgatg tacgcctggc agttctcgaa gatgcagtac accgccgagc ggcacggctg
    18361 gacgaagttc gtgtcgatgc agaaccacta caacctcctg taccgcgagg aggagcggga
    18421 gatgctgccc ctctgcgcgg accagggcgt cggcgtgctg ccctggagcc cgctcgcccg
    18481 cggccgcctc acccgcgact gggacaccgc caccgagcgc agcgccaccg acaacttcgg
    18541 cagcaccctc taccaggagg gcgaccgtgc cgtggtggac gccgtcaccc gcatcgccgg
    18601 cgaccgcggc gtgccgcgcg cccaggtggc cctggcctgg ctgctgcacc gctccacggt
    18661 gaccgcgccg atcatcggcg cctcgaagtc gcggcacctc gaggacgccg tggcggcggt
    18721 cgaactgacg ctcaccgaga aggaagccga ggaactggag cggccctacg cgccgcaccc
    18781 gatcgccggt cactgacccc gcggggagcg ccccgtcgcc tcagggcccg gtccccgctt
    18841 ccagggcggt gacggacacc gacgactcgt cgccgcccac cgggacctca ccggccgtcc
    18901 acgcgacctc gatggggtcc cgctcgtccg gcggggtgac cagcagggcc gccggggtcg
    18961 cggtgcgggc gccgctgatc tgcgggctgg agaaggacag tccggcccac gcgctcttcc
    19021 cgggcgtcag ggtgagcgtc acgggggagg agggcgcgcg gtcggggtcc gggccgagct
    19081 gctcgccgga cgcgtccacg aacgcggcgc ccggatagcc gtacaccgtg caggtgcggt
    19141 cggaggtgtt ggtcagcacg accgggaagt tgcgctgtcc ggcgcccggg tcgacgcggc
    19201 cgacggcggc gcgcagctcg gaggtgtggc agcggccgtc ggtgcgggcc gaggcggagg
    19261 ccgatccggc ggtgtcgctg ggcgtggtgc cgtcggcggg cgcggtggcg gcaccggagt
    19321 ccgggccggg cgtgctcggg gcctcggtgg ctcgcggggt gctcgcgctc ggcgtgccgc
    19381 tctcgctgcc gcacgcggtc agtacgccga gcaccgcgag cgcactcgcg agcagggccg
    19441 tccggcacag gggctgggac gtgttcggca tcgcttctcc acactcccgt gaggtgccgc
    19501 gcacggcccg ccgcgcggga cggcgccgta cgccctgtgc tctcgagtgt cccgccgcac
    19561 gggccgggaa acgagggcgc gcccggtacc cgtccgcgcg ctccccccgg tcactcctcg
    19621 tcgagcagcc ccagttccgc ccagatcgtc ttgccctcgg tcgtgtgccg gctgccccag
    19681 cgctgggtca gctgggccac cagcagcaga ccgcggccgc cctcgtccca ggtcttggcc
    19741 cggcgcaggt gcggcgcggt gtggctggtg tcggagacct cgcagatcag cgtcgccctg
    19801 tcgtggatca gtcgcagccg gatgggcggg gagccgtacc ggatggcgtt ggtcaccagc
    19861 tcgctcacca ccagttccgc cgtgaacgac gcctccagca gggaccagac ggacagttgc
    19921 tcgacgacct gtttgcggac gggggcgacc agcgacgggt cgttcgggat gtcccaggtg
    19981 gcgacctgac cggcgggcag cccccgggtc cgggccagca gcagggccac gtcgtcggcg
    20041 gcgccgcccg acggcagcag ggcgtgcagc acccggtcgc acagggtgtc cagcgagtcg
    20101 gtggagggga ccagcgcctc gcgcagcagc gtctgaccgg cgtcggcgtc ccgctcccgg
    20161 ctctccacca gcccgtcggt gtagaacgac agcacgctgc cctcgcgcag ctccagctcg
    20221 gcggactcga acggcagccc gcccacgccg agcggggggc cggagggcag gtcgatctgc
    20281 cggggcgggc cctccggcgg gaccaggacc ggtgccgggt gcccggcccg ggccagcgag
    20341 cagcgccgcg acaccgggtc gtacaccgcg tacaggcagg tggcgccgac ctcgccggtg
    20401 ccgtcgtcgc cggactcctc ggacagccgg acgaccaggt cgtcgaggtg ggtgaggagt
    20461 tcgtcgggcg tcagatcgat gtcggcgagc gtgcggaccg cggtgcgcag ccggcccatg
    20521 gtggccgagg cctggatgcc gtggccgacg acgtccccga cgaccatcgc cacccgcatc
    20581 ccggacagcg ggatgacgtc gaaccagtcg ccgccgaccc cggagcgcgc cgccggcagg
    20641 tagcgggagg ccgcctccac cgcggcggtg ggcggcagcc accgggggag caggctgcgc
    20701 tgcagggtca gcgtcgactc ccgctcgcgg gagtagcggc gggcgttgtc gatgcagacg
    20761 gcggcgcggg cggtgacctc ctcggcgagc agccggtcgt cgtccgtgaa ggggtagggc
    20821 cgccggaagc gggtgaacac cgcgacaccg agggtggtgc cccgggcctg caacggcacg
    20881 gacatcgtgg agtggatgcc gtactcctcc acccgctgga cgcgcaccgg atcccactcc
    20941 cgccagcgct ccaggtcgcc gctgggcacc tcggcgacga tcgcgcggcc cgcgaccagg
    21001 cattcggcct ggggcgatcc ggccgggtag ac
//
