LOCUS       NZ_CP012382            24535 bp    DNA     linear   CON 26-APR-2024
DEFINITION  Streptomyces ambofaciens ATCC 23877 chromosome, complete genome.
ACCESSION   NZ_CP012382
VERSION     NZ_CP012382.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces ambofaciens ATCC 23877
  ORGANISM  Streptomyces ambofaciens ATCC 23877
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
            spiramycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303940)
  AUTHORS   Thibessard,A., Haas,D., Gerbaud,C., Aigle,B., Lautru,S.,
            Pernodet,J.-L. and Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUL-2015) Faculte des Sciences et Technologies,
            Universite de Lorraine, Boulevard des Aiguillettes, Vandoeuvre les
            Nancy F-54506, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC workbench v. 7.0.3
            Genome Coverage                   :: 114
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001267885.1-RS_2024_04_26
            Annotation Date                   :: 04/26/2024 02:57:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,510
            CDSs (total)                      :: 7,418
            Genes (coding)                    :: 7,242
            CDSs (with protein)               :: 7,242
            Genes (RNA)                       :: 92
            rRNAs                             :: 5, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 74 of 176
            Pseudo Genes (incomplete)         :: 131 of 176
            Pseudo Genes (internal stop)      :: 12 of 176
            Pseudo Genes (multiple problems)  :: 39 of 176
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6815352
            Orig. end                         :: 6839887
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012382.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24535
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /product="lanthipeptide-class-iii"
                     /region_number="20"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..24535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="neighbouring"
                     /product="hydrogen-cyanide"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..12838
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12838
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7838](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7838
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    complement(975..989)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(979..990)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.77"
                     /tool="antismash"
     misc_feature    1287..1302
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.96"
                     /tool="antismash"
     gene            1314..2183
                     /locus_tag="SAM23877_RS30020"
                     /old_locus_tag="SAM23877_6326"
     CDS             1314..2183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330308.1"
                     /locus_tag="SAM23877_RS30020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6326"
                     /product="metallophosphoesterase"
                     /protein_id="WP_053139820.1"
                     /transl_table=11
                     /translation="MTATVGGPGQLWAISDLHIGYEENRALVEKMRPESDDDWLLVAGD
                     VAETVADVRWALGTLADRFRRVIWTPGNHELWTHPKDSVTLRGAARYEHLVEMCRELGV
                     TTPEDPYPVWDGAGGPAVVAPLFLLYDYSFLPAGCATKDEGLAYAHGTGVVCNDEYLLH
                     PDPYPSREAWCRARVAETERRLAALPDGLPTILVNHYPLDRHPTEVLWYPEFAMWCGTR
                     LTADWHRRFRVATMVYGHLHIPRTTWHEGVRFEEVSVGYPREWRKRTGPPGRLRRILPS
                     PPGEETAR"
     cand_cluster    1926..24535
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1926..24535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11925:14535](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11926..14535
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
     gene            2180..2860
                     /locus_tag="SAM23877_RS30025"
                     /old_locus_tag="SAM23877_6327"
     CDS             2180..2860
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-167). E-value: 1.5e-21. Score:
                     68.6. Matches aSDomain:
                     nrpspksdomains_SAM23877_RS30025_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386034.1"
                     /locus_tag="SAM23877_RS30025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6327"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_053139822.1"
                     /transl_table=11
                     /translation="MIEDLLPATVVTVEAHGHDDAGHLPLYPEEEALVARAVDKRRREF
                     TAVRSCARRAMEKLGVPAQPVLNGERGAPRWPSGLVGSMTHCDGYCAAALVRATDLASV
                     GIDAEPDGPLPDGVLPGVSLPAEAERLRRLGRERPGVHWDRLLFSAKESVYKAWFPLTG
                     EWLDFMEADIEISVDPVDPRRGTLRAALLVPGPTVGGRRVGHFDGRWTARHGLVATAVT
                     VPHA"
     aSDomain        2489..2680
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAM23877_RS30025_ACPS.1"
                     /evalue="1.50E-21"
                     /label="SAM23877_RS30025_ACPS.1"
                     /locus_tag="SAM23877_RS30025"
                     /protein_end="167"
                     /protein_start="103"
                     /score="68.6"
                     /tool="antismash"
                     /translation="VGIDAEPDGPLPDGVLPGVSLPAEAERLRRLGRERPGVHWDRLLF
                     SAKESVYKAWFPLTGEWLD"
     gene            complement(2951..3187)
                     /locus_tag="SAM23877_RS30030"
                     /old_locus_tag="SAM23877_6328"
     CDS             complement(2951..3187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431523.1"
                     /locus_tag="SAM23877_RS30030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6328"
                     /product="hypothetical protein"
                     /protein_id="WP_053139824.1"
                     /transl_table=11
                     /translation="MTTAVLTDHERTAVQAYLRLLHTVRAGFDTAVGPADAPRPPVVPP
                     SVLAEAEQALEAAGLTGNEEAFFRLLRDWCPRP"
     gene            complement(3391..4047)
                     /locus_tag="SAM23877_RS30035"
                     /old_locus_tag="SAM23877_6329"
     CDS             complement(3391..4047)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191563.1"
                     /locus_tag="SAM23877_RS30035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6329"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_053139826.1"
                     /transl_table=11
                     /translation="MTDGLEGPDAMPTAALPAVVARVTALADRLGVPHAEVFDVGRLSA
                     ASGVPESVVGALLGGRPAGEPDVQARFVQRLDLLRRTRLKPNGRKYTQQEIADGAGMSR
                     QQAGALINGDRRPTMEHCDAIQRFFRVHAGFLTAEDPEALASALQRTEQELLQQLADRE
                     RQAAAVDDDPLERLLQDHGVRGIAWRAAQLPTDQHRDKVAEWLDMLLESVKRPES"
     misc_feature    4076..4091
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            4279..4938
                     /locus_tag="SAM23877_RS30040"
                     /old_locus_tag="SAM23877_6330"
     CDS             4279..4938
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069850.1"
                     /locus_tag="SAM23877_RS30040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6330"
                     /product="hypothetical protein"
                     /protein_id="WP_053139827.1"
                     /transl_table=11
                     /translation="MAFQAGGQRPAPRPVPASPDAQAYLQDYTALLEAVAFPSLVVDHR
                     WDVVLTNGAFRTLFRGAGPHPTAMPGDNFLRFVLFHPDASDVLGEHESSWCLPMLAHFA
                     ATLERYGHDHGLQAVRREIAQDPIMEAAYRQGLPHWMRAVGAEAVEHDGAVRPLHHPDP
                     RWGATECRVVVETPRALEELGYSRLTLVLREPRRTPPRPPRPRRGAARLRVVPASE"
     misc_feature    complement(4985..4995)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            5001..6152
                     /locus_tag="SAM23877_RS30045"
                     /old_locus_tag="SAM23877_6331"
     CDS             5001..6152
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996369.1"
                     /locus_tag="SAM23877_RS30045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6331"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_053139829.1"
                     /sec_met_domain="DAO (E-value: 1.7e-67, bitscore: 227.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESLTCDVVVVGAGMVGAACAWSAARSGLDVIVVDRGPVAGGTT
                     GAGEGNLLVSDKAPGPELELALLSARLWSELAGELGRAVEYEAKGGVVVAETPEALAGL
                     ETFAAGQRAAGVAAETVPADRLHDLEPRLAPGLAGAVHYPQDAQVMPALAAAHLLRASG
                     ARLRTGRTVTGVLRGPDDAVRGVRTDRGDLHAPAVVNAAGPWAGELAAQAGVRLPVLPR
                     RGYVLVTEPLPPRVWHKVYAADYVGDVASDSAALRTSPVVEGTAAGPVLIGASREQVGF
                     DRSVSVPALRALAEGATRLFPFLAGVRVVRAYAGFRPYLPDHLPAIGPDPRAPGLFHAC
                     GHEGAGIGLSTGTGYLIAQLLSGERTALDLTAFRPDRFPEEAP"
     gene            6149..6448
                     /locus_tag="SAM23877_RS30050"
                     /old_locus_tag="SAM23877_6332"
     CDS             6149..6448
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009323366.1"
                     /locus_tag="SAM23877_RS30050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6332"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_053139831.1"
                     /sec_met_domain="Fer2_4 (E-value: 3.7e-27, bitscore: 92.9,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLRLVRARPAPAFTVTVDGRPTRALPGRTVAAALWAAGITSWR
                     TTRGSGRPRGVFCGIGVCFDCLVTVNDRPNQRACLVPVRPGDAIRTQVGTGHED"
     gene            6438..7838
                     /locus_tag="SAM23877_RS30055"
                     /old_locus_tag="SAM23877_6333"
     CDS             6438..7838
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996367.1"
                     /locus_tag="SAM23877_RS30055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6333"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_053139833.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.9e-27, bitscore:
                     95.0, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 2.3e-12, bitscore:
                     45.9, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTDLAVVGAGPAGLAAALAAAAGGLRVTVLDAGDQPGGQYFRQP
                     AAELGARRPQALHRQWRTWERLRGALADSGVRVLTEHHVWFVEERSGAFTVRALLGPGQ
                     DEPADVHADAVLLATGGYEHVLPFPGWTLPGVVTAGGAQAMLKGGLVVPGRTAVVAGTG
                     PLLLPVATGLAAAGVRVAALVESADPKRVAGHARALAGKLPEGAALAARLLRHRVRPLT
                     RHTVVRAHGDDRLTGVTVAALDPAGRVRRGTGRHLACDTLAVGHGMLPHTDLADGLGCR
                     LDGPAVAVDAEQRTSVPGVWAAGEATGIGGAALALAEGHLAGRSIAARLRGDDPDPAGR
                     ARAVRARETLRTAAAALAAAFPPPAHWTGQVTDDTVVCRCEEVTAGAVREAVDGLGADD
                     VRTVKLLTRAGMGWCQGRMCAPAVAGLTGCEPGPARRPFARPVPLGVLARTRAEEPGAT
                     QETERGPS"
     gene            7835..8725
                     /locus_tag="SAM23877_RS30060"
                     /old_locus_tag="SAM23877_6334"
     CDS             7835..8725
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525029.1"
                     /locus_tag="SAM23877_RS30060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6334"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_053139835.1"
                     /transl_table=11
                     /translation="MTDHRPWRGVLVATALPLHEDLSVDHDAYAEHCAWLVANGCDGVV
                     PNGSLGEYQVLTPEERTRVVETAVAAVGGARVVPGVAAYGCAEARRWAEQAREAGCGAV
                     MLLPPNAYRADERSVLAHYAEVARAGLPVVAYNNPVDTKVDLVPEVLARLHGEGHIQAV
                     KEFSGDVRRAYRLAELAPELDLLAGADDVLLELAIAGAKGWIAGYPNALPAACVELYRA
                     AVTGDLVTAGRLYRQLHPLLRWDSKVEFVQAIKHSMDLAGRHGGPCRPPRVPLQPDQEA
                     AVRAATEKALAAGLA"
     gene            8735..9736
                     /locus_tag="SAM23877_RS30065"
                     /old_locus_tag="SAM23877_6335"
     CDS             8735..9736
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358096.1"
                     /locus_tag="SAM23877_RS30065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6335"
                     /product="proline racemase family protein"
                     /protein_id="WP_053139837.1"
                     /transl_table=11
                     /translation="MRSRLVLHAVDSHTEGMPTRVVTGGVGTIPGATMNERRLYFREHR
                     DDVKRLLMNEPRGHAAMSGAILQPPTRPDCDWGVVYIEVSGYLPMCGHGTIGVATVLVE
                     TGMVEVVEPVTTIRLDTPAGVVVAEVAVEGGAARAVTLRNVPSFAAGLDREVTLPDGRT
                     VRYDLAYGGNFYAILPLERLGLPFDRSRKDEILAAGLALMAAVNDAEEPVHPEDPSIRG
                     CHHVQVTAPDATARHSRHAMVIHPGWFDRSPCGTGTSARMAQLHARGELPPHTEFVNES
                     FIGTRFTGRLLGTTEVGGRPAVLPSFTGRAWITGTAQYLLDPEDPFPAGFVL"
     gene            9733..10428
                     /locus_tag="SAM23877_RS30070"
                     /old_locus_tag="SAM23877_6336"
     CDS             9733..10428
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525027.1"
                     /locus_tag="SAM23877_RS30070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6336"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_053139839.1"
                     /transl_table=11
                     /translation="MNAGGPALPVLGGRKTSHRERVAEALRAALIAGELRPGEVHSAPG
                     LAARFGVSATPVREAMLDLAKEGLVDTVPNKGFRVTAVSDRQLDEYTHIRSLIEIPTTA
                     ALAGTADPTALEALRPVAEEIVTSAAAGDLIAYVEADLRFHLGLLELAGNAHLVDVVRD
                     LRRRSRLYGLTALVEQGRLQASAEEHLEILDALLARDEEAVRAVMTRHLGHVRGMWAAR
                     VGEAAAPPS"
     gene            10757..11575
                     /locus_tag="SAM23877_RS30075"
                     /old_locus_tag="SAM23877_6337"
     CDS             10757..11575
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999401.1"
                     /locus_tag="SAM23877_RS30075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6337"
                     /product="IclR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_079030520.1"
                     /transl_table=11
                     /translation="MPEDAVRAPHFVRSFERGLAVIRAFDADHPALTLSEVARAAELTR
                     AAARRFLLTLADLGYVHTDGRLFRLTPRVLELGYSYLAGFTLPQIAEPHLERLVARVRE
                     SSSLCVLEGDDIVHVARVPARRIMAASITVGARFPAHLTSVGRVVLAGLPEAEAEVRIA
                     RADLRPHTARTLTSADALRAELRRVRRQGYALVDQELEDGLRAVAAPVRDRDGEVVAGV
                     GIAVHAGRNSVESVRRDLLPHLLATAARIDADLRITGPARTAGHDGGTRG"
     misc_feature    11817..11834
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.66"
                     /tool="antismash"
     misc_feature    complement(11848..11860)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    complement(11882..11894)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            11926..14535
                     /gene="lanKC"
                     /locus_tag="SAM23877_RS30080"
                     /old_locus_tag="SAM23877_6338"
     CDS             11926..14535
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982960.1"
                     /locus_tag="SAM23877_RS30080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6338"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_053139843.1"
                     /sec_met_domain="micKC (E-value: 1.5e-240, bitscore: 799.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.6e-10, bitscore: 38.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVYCDADPYFYDAPHRTSPRTGAGRSRYAAASRPVPEGWQ
                     RNESGDWLALRPVDAVLPDQGWKIHVAACLDNAESVLDRVWRHCVERGTAFKFVPSRYL
                     LHQRNAKYADRAGSGKFITVYPADEADFERLVDELSGLLSGEPGPHILSDLRIGAGPVH
                     VRYGGFTRRNCYDANGELRPAVTGPDGVLVPDLRGPAFRIPDWVRPPAFLRPHLDARAA
                     VTVSGLPYAIESALHFSNGGGVYLARDTRTGEQVVLKEARPHAGLAADGADAVARLHRE
                     RRALELLSGLDCTPEVLDHLTIGEHHFLVLEHVDGKPLNTFFARRHPLIEADPDARRLA
                     EYTAWALEVHARVERAVADVHARGVVFNDLHLFNIMIREDDSVTLLDFEAAHHVDEPGR
                     QTVANPGFVAPSDRRGVAVDRYALACLRLALFLPLTSLLALDRRKAAHLADVIAEQFPV
                     ERSFLDAAVDEITAGADGARPERRPAGPVAPVRPHDWPRSRESMAEAIRASATPSRTDR
                     LFPGDIAQFATAGGGLAFGHGAAGVLYALAESGAGRDEDGEQWLLERTKQPPSGMPHGF
                     HDGLAGLAWTLERLGHRDRALDLVELLLDQPFDHLGADLHSGTAGLGLALDSLAATTGE
                     SALHAAALRCAELTAAGTSAGSEGSGRPRAGLLYGAAGRALLFVRLFERTGDPSFLDLA
                     RDALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRDDEEFARARG
                     EIVAAAQAMFYAQPGLYRGVAGMVLHLGRTTAPVPGTGPAAVRRQLDALAWHAMSYRDR
                     LAFPGEQMMRLSMDLSTGTAGCLLAVASVLGDEPAALPFLPPLPPDSGPQTRPRQGS"
     misc_feature    14568..14585
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 13.99"
                     /tool="antismash"
     gene            14573..14701
                     /locus_tag="SAM23877_RS30085"
                     /old_locus_tag="SAM23877_6339"
     CDS             14573..14701
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="SAM23877_RS30085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6339"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_003972313.1"
                     /transl_table=11
                     /translation="MNLFDLQSMETPKEEAMGDVETGSRASLLLCGDSSLSITTCN"
     CDS_motif       14573..14635
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLFDLQSMETPKEEAMGDVE"
                     /locus_tag="SAM23877_RS30085_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14636..14701
                     /prepeptide="core"
                     /locus_tag="SAM23877_RS30085_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="32.20"
                     /molecular_weight="1955.2"
                     /monoisotopic_mass="1954.0"
                     /core_sequence="TGSRASLLLCGDSSLSITTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSMETPKEEAMGDVE"
                     /leader_location="[14572:14635](+)"
                     /alternative_weights="1973.2"
                     /alternative_weights="1991.2"
                     /alternative_weights="2009.2"
                     /alternative_weights="2027.3"
                     /alternative_weights="2045.3"
                     /alternative_weights="2063.3"
     gene            14872..16644
                     /locus_tag="SAM23877_RS30090"
                     /old_locus_tag="SAM23877_6340"
     CDS             14872..16644
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471139.1"
                     /locus_tag="SAM23877_RS30090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_053139846.1"
                     /transl_table=11
                     /translation="MAETRPRKRRPPSARDAADRAKRGRGLEALVLSCSVAAAVAAVAQ
                     PVVLGRTLDLLLRDGDAGRWLALSAALLVGELLFDCLTSLFTGRCNAARTASVRRGALA
                     GLLRAVPDRARARTPGDVGTRLTLNAADAGGAPAAKASLAASLVTPLGALAALAFVDLW
                     VTACVLAGLPALALVLRAFARDTGASVAAYQRTQARIASRLLETLEGTATITAAGTAAR
                     ERARVLAPLAELAGQGRQMWALHGRALARSGVLVPLLTLAATAVGGLRLASGDLSVGDM
                     LAACRYAQLAAGVGGTASLLGAVVRGREARRRTLELEEMPPLAHGAFRLPPDGPGGLEL
                     RGVRVVRDGREVLRADGVRVPGGTTVAVVGRSGSGKSVLAAVAGRLVDPDEGHVLLDGV
                     RLDRLTRQELRTEVAFAFERPELGEGTVAEVIAAGARRASPEQVRQAAHAAGADGFVRR
                     LPRGYDTPLASAPLSGGERQRLGLARAFAHAGRLLVMDDATSSLDTATEHEVDRALRRS
                     VRPGTRLVVAHRQSVAGRADLVLWLEDGCVRAVGTHRELWELPGYRAVFATGGTGPAAA
                     CETPAAPRPEEVRP"
     gene            16641..18770
                     /locus_tag="SAM23877_RS30095"
                     /old_locus_tag="SAM23877_6341"
     CDS             16641..18770
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827682.1"
                     /locus_tag="SAM23877_RS30095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6341"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_107408687.1"
                     /transl_table=11
                     /translation="MTAAGYHGAASPEAGGPGGSRDGESGGFRDGESGGFRDRGSRGGK
                     PGGFRDEGSRGCRDDGAGTLRRVAPSARRFLGRRKGVLVRLALWSLAESGQAFLVGYGV
                     AHAVDAFLAGDTRRGLLWLAVALVAVLSGAPVVRGVFAQLAGLTEPLRDGLVRHAVDRS
                     MARAAATGSGGTDRAAVSRLTNQVEIARDSFAGLVLTLRSFVFTAAGALLGLLSLAPAL
                     LVVVLPPLAGGLALFLVTLRPMAAAQRRALAADEALGDHAARSRAALRDLTACGTGPEA
                     ERRGGELVDDAAAAARLLAGWAAVRTAALGVAGHLPVLALLAAVPWLRGRGVSAGVLLG
                     AFTYLVQSLLPALHTLMTALGTAGARLLVVLDRILGPDSAPVPMPERDPVPVPVPAARD
                     GVRPTPASPAAVGADRAGGADRTGGADRTGGADRTGGADRTGGTDPLGGRPADVRLPAG
                     DAHRASGRPAAAVELRSVTLSYGVRAEPVLDSLDLNVAPGEHLAVVGPSGIGKSTLTRL
                     IAGTLAPSGGEVRVAGRPVTGRPTAELAALRVLVPQEAYVFSGTVGENIAYLRPDACRA
                     ELDAAARVLGLRPLIERLGGLDAPVRPAELTHGERQLVALTRAYLSPAPLLLLDEATCH
                     LDPASEARAEEALARRPGTVLVVAHRLSSAVRADRVLVLDGVEAVCGTHEELLDRSPLY
                     RDLTGHWHAGPLGQA"
     gene            complement(18834..19430)
                     /locus_tag="SAM23877_RS30100"
                     /old_locus_tag="SAM23877_6342"
     CDS             complement(18834..19430)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037659.1"
                     /locus_tag="SAM23877_RS30100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6342"
                     /product="response regulator transcription factor"
                     /protein_id="WP_053139848.1"
                     /transl_table=11
                     /translation="MVRTVVVHDEELLRSALVQLLRSDDTLEVTSLCPGSQEPTGEELP
                     ADVCVVDGEYLHAPGDVRGPRLRDAYGDRLVVLTTARRPGVLRRAFDAGALGLVDKNAP
                     VQRLLTAVHTVAKGERFLDETLTVALLQGAEMPLTTRELSVLSLAAQGAPIAEIAARLH
                     LSRGTVRNYMATAIRKVGARNRVDAIRIVQSAGWT"
     misc_feature    19524..19539
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.4"
                     /tool="antismash"
     gene            complement(19984..21279)
                     /locus_tag="SAM23877_RS30105"
                     /old_locus_tag="SAM23877_6343"
     CDS             complement(19984..21279)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386073.1"
                     /locus_tag="SAM23877_RS30105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6343"
                     /product="MFS transporter"
                     /protein_id="WP_053139850.1"
                     /transl_table=11
                     /translation="MVAIMTGMHTEAPPVRRPVRQLLAASVGNAVEWYDWYAYTFLATY
                     IADQVFPQGAENSLVPLLSTFAVFAVGFFMRPVGGLVMGAIADRRGRRAALTVTILLMG
                     GSSLLVGLTPTYAAAGVLAPVVLVVARLLQGLSVGGEFAASTTFLVESAGPGRRGLFSS
                     FQYVSTTAGQLVASGVATVLVDTLSEERMNGWGWRVPFVVGAVLSLVGFWIRRGAAETR
                     SAEQRKGPRPGLFEALRRHPRESLLICGITAGGTLAYYTWTSYLPTYAELNVGVEKSDA
                     LLAGTISLAFFGLLQPLGGLLSDRFGRRPSLLFFGVGFALLSVPLLHALRDSFAVLLLV
                     SCAGMILLTGFTSISAAVNAEVFPPRVRAAGIGFPYSLTVALFGGTAPYVGTLLKDLGH
                     SGLFPWYVAVLCLLSSLVYLRLPETAHRELER"
     gene            21452..23503
                     /locus_tag="SAM23877_RS30110"
                     /old_locus_tag="SAM23877_6344"
     CDS             21452..23503
                     /GO_function="GO:0004629 - phospholipase C activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972304.1"
                     /locus_tag="SAM23877_RS30110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAM23877_6344"
                     /product="phospholipase C, phosphocholine-specific"
                     /protein_id="WP_053139852.1"
                     /transl_table=11
                     /translation="MPEVNRRRFLQVAGATTAFSALSASIERAAALPANHRSGTIEDVE
                     HIVVLMQENRSFDHYFGKLRGVRGFGDPHPVTLDNGRSVWHQAKDGKEVLPFHPEADDL
                     GMQFLEGLPHGWSDGQDAYHNGKYDRWLPAKGTTTMAYLTREDIPFHYALADTFTVCDA
                     YHCSFIGSTDPNRYYLWSGHTGNDGKGGGPVLGNDELGYDWTTYPERLEAAGVSWKVYQ
                     DIGDGLDAAGSWGWIDDAYRGNYGDNSLLYFNKYRDAKPGDPWYDKARTGTDAKSGEGY
                     FDRLRADVKAGRLPQVSWIAAPEAFSEHSNWPSNYGAWYISQVLDALTADPAVWAKTAL
                     FITYDENDGFFDHVVPPLPPKSAAQGLSTVDVSLDVFKGSAKHREGFYGLGPRVPMLVV
                     SPWSKGGYVCSETFDHTSVIRFMERRFGVREPGISPWRRAICGDLTSAFDFSRHDSRPA
                     GLPDTDAYEPPDRVRHPDYRPTPPADPDMPRQERGLRPARPLRYAPRVDGAVDAAAGTF
                     RLAFASGAGAGAAFLVTSGNRTDGPWTYTTEAGKSIADTWNSAYSAGSYDLTVHGPNGF
                     LRVFRGRNKTTGPEVTARHAGDDVRLTVTNTGSGTVRLRVANAYGGRPGTVTVRPGATV
                     HHTVDLARSRRWYDVTVTSEADPAFLRRFAGHVENGRPGVSDPAIVTD"
ORIGIN
        1 ggggagggac accggtcgca ggggacgcgg tccggacacc accgcgtagt cctggcccag
       61 gaacggcggg gtcagctcgc ccgggtcgtc gccgagggcc agccggaccg ccgcccaggg
      121 cgcgttgaca ccgcacagcg ccagctggtg cagcccaccc gccgggcggg tgttgacgtc
      181 catcaggacg ggccggtcgc cgtacatccg gaactgcacg ttggacaggt ggtgcagccc
      241 gaaggcctcg gcgatcagcc gggccggtgc cagccactgc tcgtggagcg tgaacccccg
      301 gcggcggccg ttcttggtgc ggcccacggc cagccgcacc cggttgtcgg gcccggtgag
      361 gcagtccacc gagacctccg gctgctccag ccgcggcatc accagccagt cgaccggctc
      421 ctccgccgcc cgcagcgcct cgacgaccag cggcagcggc acgtccgggc tcgggaagcc
      481 gttcaggtgg gcgagggaga aggggtcgcg ggtgaccatc cggaagccca cgccgcccgc
      541 gccggacgcc ggtttgaaac acgcccggtg cccgtgcgcc tccaactcct cgaccgcgga
      601 gacgagttcg tcggccgtgc ggacccgcca ccagggcggg accggcacgc cgatcgcccg
      661 caccgcctcg taggcgatca ccttgtcctg gaagacggcc accgcctccg ggggcggtgc
      721 cagcaacgcc gtaccggccg cctcgaagtc ggcacggtgg gccacgaccg ccgcctggtg
      781 cagacggggc acgaacacgt ggatgccccg gcgcgcgcac tggtccaggg cgtactcgac
      841 gtaaccggcc ggggacaggc cctccggctc cagctcggcc gtgtcggccg cggccaggac
      901 gggggagtcc gggtcaccgt gcgtggcgtg gatctcgacg gcccggtcgg cgggatttct
      961 ccgcagctga tccatgaaga agacgttctc cgcgtacgtg cggttgagcc agacgcgtac
     1021 gggagaaacc atgcaggccg cctttcacgg ttcacgggca gggcgaagca ggccgtgccc
     1081 ggccaggggg gttggaggga caccaagccg ccctgcgcgg agggagaatc gtggcggtgg
     1141 tgtcggggcg atcatagggg gtcccgcgcc tgtgagcgca aagcgcgtca cacggatgcg
     1201 cccgcgccga gacggggcgg gcgcgcaggc cggtccggcc cggcgagccg cccttgtgag
     1261 cgggtccggg atgtgatctc gtgatctcga acgcgcgtcc ggaaggggtg gggatgacgg
     1321 cgacggtcgg tggtccgggg cagctgtggg ccatcagcga cttgcacatc gggtacgagg
     1381 agaaccgcgc actggtcgag aagatgcggc ccgagtccga cgacgactgg ctcctggtgg
     1441 ccggcgacgt ggcggagacc gtggccgacg tccgctgggc cctcggcacc ctcgcggacc
     1501 gcttccggcg ggtgatctgg acccccggca accacgaact gtggacgcac cccaaggact
     1561 ccgtcaccct ccggggcgcc gcccgctacg agcacctcgt cgagatgtgc cgcgagctgg
     1621 gcgtgacgac gcccgaggac ccgtacccgg tgtgggacgg cgccgggggt ccggcggtcg
     1681 tggccccgct gttcctgctc tacgactact cgttcctgcc cgcgggatgc gcgaccaagg
     1741 acgaggggct ggcgtacgcc cacggcaccg gcgtcgtgtg caacgacgag tacctgctcc
     1801 atcccgaccc gtatccgagc cgcgaggcct ggtgccgggc gcgggtcgcc gagaccgagc
     1861 gcaggctcgc cgcgctcccc gacgggctgc cgacgatcct cgtcaaccac tacccgctgg
     1921 accgccaccc caccgaggtc ctgtggtacc cggagttcgc catgtggtgc ggcacccggc
     1981 tgaccgccga ctggcaccgc aggttccggg tcgccaccat ggtctacggg cacctgcaca
     2041 tcccgcggac cacctggcac gagggcgtcc gcttcgagga ggtgtcggtg ggctatcccc
     2101 gggaatggcg caagcggacc gggccgccgg gccggctccg ccgcatcctg ccgtcgccgc
     2161 ccggagagga gaccgcccgg tgatcgagga cctgctgccc gccacggtgg tcaccgtgga
     2221 ggcccacggc cacgacgacg ccgggcacct gcccctctat ccggaggagg aggcgctcgt
     2281 ggcgcgggcg gtcgacaagc gccgccggga gttcaccgcg gtacggtcct gcgcgcgccg
     2341 cgccatggag aaactcggcg tgcccgccca gcccgtgctc aacggcgaac gtggtgcgcc
     2401 gcggtggccg tccgggctgg tcggcagcat gacccactgc gacggctact gcgccgccgc
     2461 tctggtccgc gccaccgacc tggcctccgt cggcatcgac gccgaacccg acgggccgct
     2521 cccggacggc gtcctgcccg gagtgtccct gcccgccgag gcggagcggc tgcgccggct
     2581 gggccgggag cggcccggcg tccactggga ccggctgctc ttcagcgcca aggagtcggt
     2641 gtacaaggcg tggttccccc tcaccgggga gtggctggac ttcatggagg ccgacatcga
     2701 gatctctgtg gacccggtgg acccgcgccg cggcaccctg cgcgccgctc tcctggtgcc
     2761 gggccccacc gtgggcggcc ggcgcgtcgg ccacttcgac ggccgctgga ccgcccggca
     2821 tggcctggtg gccacggcgg tcacggtccc gcacgcctga gccccgcggc ccgggacgcg
     2881 agccccgggc gccgtcggtg ccggcggacc cgcgccccgg gccgggcggc gcggtcggcc
     2941 ggcgtgcgcg tcacggccgc gggcaccagt cgcgcaggag ccggaagaac gcctcctcgt
     3001 tcccggtcag tcccgcggcc tccagcgcct gctccgcctc ggccagtacg gagggcggga
     3061 cgacgggtgg ccgcggggcg tccgccggtc ccaccgcggt gtcgaagccg gcccgcacgg
     3121 tgtgcaggag ccgcaggtag gcctgaacgg ccgtgcgctc gtggtcggtc agtacggcgg
     3181 tggtcatcgg tcggctctcc ccacaacgac gtcagcggtc acgcgccccc gcacggcggc
     3241 ggcacactcc cagcttgccg ccccccactg acaatccggc cgaaccccgc cccgcacacg
     3301 gtgccgtggc tcacccgtcc cccgcggacc agcggccggc cggctcgccg cgcggtcggc
     3361 gcacccgtcc ccgggggcct ctccccggcc tcacgactcc ggtcgtttga cgctctccag
     3421 gagcatgtcc agccactcgg cgaccttgtc gcggtgctgg tcggtgggca gttgcgcggc
     3481 ccgccaggct attccgcgta cgccgtggtc ctgcagcagc cgctccaggg ggtcgtcgtc
     3541 gacggccgcc gcctgccgct cccggtcggc gagctgctgc aacagctcct gctcggtgcg
     3601 ctgcagggcg ctcgcgagcg cctccgggtc ctcggcggtc aggaatccgg cgtgcacccg
     3661 gaagaagcgc tggatggcgt cgcagtgctc catggtgggc cgccggtcgc cgttgatgag
     3721 ggcgcccgcc tgctgccggg acatgccggc gccgtcggcg atctcctgct gggtgtactt
     3781 gcggccgttc ggcttcagcc gggtgcggcg cagcaggtcc aggcgctgca cgaaccgggc
     3841 ctgcacgtcg ggttcgccgg ccgggcgccc gccgagcagc gcgcccacca cggactcggg
     3901 gacgccggag gcggcggaca ggcggccgac gtcgaagacc tcggcgtgcg gtacgccgag
     3961 ccggtccgcg agggcggtga cgcgggcgac gacggcgggc agcgccgccg tcggcatggc
     4021 atccggaccc tccaagccat ccgtcaccga cagctctcct acgtctctca caggcctcac
     4081 aggctttgca cgagcggttg ccgtgaactc ccggagagta gcctgccgct cgaactcaca
     4141 tccaggtctc gccacaactg tggccaattt gagccgtcaa caggcacgaa atgccacgat
     4201 agttgacacg cctcgcaccg gggcaccagg atcgggacgc cgcgagaagg ccgcataggc
     4261 aagaggggtg acctcccgat ggcatttcag gcaggagggc agcggccggc gccgcggccc
     4321 gttcccgcga gccccgacgc ccaggcgtat ctccaggact acaccgcgct cctggaggcc
     4381 gtcgccttcc cgtccctcgt cgtcgaccac cgctgggacg tggtgctgac caacggcgcc
     4441 ttccggacac tcttccgcgg ggccggcccg catccgacgg ccatgccggg cgacaacttc
     4501 cttcggttcg tcctcttcca cccggacgcg tccgacgtcc tcggggagca cgagtcgagc
     4561 tggtgcctgc ccatgctggc gcacttcgcc gccaccctgg agcggtacgg ccacgaccac
     4621 ggtctacagg ccgtccgccg cgagatcgcc caggatccga tcatggaggc tgcctaccgc
     4681 cagggcctgc cgcactggat gcgcgcggtc ggcgccgagg ccgtcgaaca cgacggcgcg
     4741 gtacggccgt tgcaccaccc cgacccgcgc tggggcgcca ccgagtgccg cgtcgtggtc
     4801 gagaccccga gggcgctgga ggagctgggc tacagccgct tgacgctggt gctgcgcgag
     4861 ccgcgccgca caccgccccg ccctccgcgc ccccgacgcg gtgccgcccg cctgagggtg
     4921 gtccccgcct ccgagtgacc cgccgcggcg acggcgacgg ccctgttccc agtagatgtg
     4981 atgtgtgaca tagtactggc gtgatcgagt cgctgacctg cgatgtcgta gtggtcgggg
     5041 ccggaatggt gggtgcggcc tgtgcgtggt ccgccgctcg ctcggggctc gacgtgatcg
     5101 tcgtggaccg tggcccggtg gccggcggca ccacgggagc gggggagggc aacctcctcg
     5161 tctccgacaa ggcacccggt cccgagctgg aactcgccct gctgtccgcg cgcctgtgga
     5221 gcgaactggc cggggagctg ggccgcgccg tcgagtacga ggccaagggc ggtgtggtcg
     5281 tcgccgagac ccccgaggcg ctggccggcc tcgagacctt cgccgccggc cagcgggcgg
     5341 ccggtgtggc ggcggagacc gttccggcgg accggctcca cgacctggaa ccccgtctcg
     5401 cccccggcct ggcgggcgcc gtgcactatc cccaggacgc ccaggtgatg cccgccctgg
     5461 ccgccgccca cctgctgcgg gcgtcggggg cccggctgcg caccggccgg acggtgaccg
     5521 gcgtcctgcg cggccccgac gacgccgtgc gcggagtgcg tacggaccgc ggcgacctgc
     5581 acgcacctgc ggtcgtcaac gcggccgggc cctgggccgg cgaactggcc gcccaggccg
     5641 gtgtccggct gccggtcctg cccaggcgcg gctacgtcct cgtcaccgaa ccgctgccgc
     5701 cccgcgtgtg gcacaaggtg tacgccgcgg actacgtcgg cgacgtcgcc agcgactcgg
     5761 ccgccctgcg gacctccccg gtcgtggagg ggacggccgc gggaccggtc ctcatcggcg
     5821 ccagccgtga gcaggtcggc ttcgaccgtt cggtgtccgt gccggcgctc cgggcgctgg
     5881 ccgagggcgc gacgcggctg ttccccttcc tggcgggtgt gcgggttgtg cgcgcctacg
     5941 ccggcttccg gccctacctg cccgaccacc tcccggcgat cggccccgac cccagggcgc
     6001 ccggtctctt ccacgcctgc gggcacgagg gggcgggcat cggactgtcc accggcaccg
     6061 ggtacctgat cgcccagctg ctgagcggtg agcggacggc cctcgacctc accgcgttcc
     6121 gtcccgaccg ctttcccgag gaggccccgt gaatcccctc cggctggtcc gggcgcggcc
     6181 cgcgcccgcc ttcaccgtca ccgtcgacgg ccggccgacc cgggcgctgc ccggccggac
     6241 cgtcgccgcc gcactctggg cggccggcat cacctcctgg cgcaccaccc gcggatcggg
     6301 ccgcccgcgc ggggtcttct gcgggatcgg agtgtgcttc gactgcctgg tcaccgtcaa
     6361 cgaccggccc aaccagcgcg cctgcctggt ccccgtgcgt cccggggacg ccatccgcac
     6421 ccaggtgggg accggccatg aggactgacc tggcggtggt cggggcgggg ccggccgggc
     6481 tcgcggcggc gctcgctgcg gcggcgggag ggctgcgggt gacggtcctc gacgccgggg
     6541 accagcccgg cgggcagtac ttccggcagc ccgccgccga gctgggcgcc cggcggccac
     6601 aggccctgca ccgccagtgg cgcacctggg aacggctgcg gggcgcactc gccgacagcg
     6661 gcgtacgcgt cctgacggag catcacgtgt ggttcgtcga ggagcggtcc ggcgccttca
     6721 cggtgcgcgc cctgctcgga cccgggcagg acgaaccggc cgacgtgcac gcggacgcgg
     6781 tgctgctcgc caccggcggc tacgagcacg tcctgccctt ccccggctgg accctgcccg
     6841 gtgtcgtcac cgccgggggc gcccaggcca tgctcaaggg cgggctggtc gtgcccggga
     6901 ggaccgccgt ggtcgccggc accgggccgc tgctgctccc ggtggctacc gggctcgcgg
     6961 cggccggcgt ccgggtggcc gccctcgtcg agtcggccga cccgaagcgc gtcgccggcc
     7021 atgcccgcgc cctggccggc aagctccccg agggcgccgc ccttgccgcc cgactgctgc
     7081 gccaccgcgt ccgcccgctc acccggcaca ccgtcgtccg cgcccacggc gacgaccgcc
     7141 tgaccggtgt caccgtcgcg gccctcgacc cggccggacg ggtccggcgg ggcaccggac
     7201 gccacctcgc ctgcgacacc ctggccgtcg gccacggcat gctcccgcac accgacctgg
     7261 ccgacggcct cggctgccgc ctggacggtc cggccgtggc cgtcgacgcc gagcagcgca
     7321 cgagcgtccc cggcgtctgg gcggccgggg aggccaccgg catcggcggc gccgccctgg
     7381 cactcgccga gggacatctc gccggacgct cgatcgcggc ccggctgcgg ggcgacgacc
     7441 ccgacccggc cggacgggcg cgggccgtga gggcgcgcga gacactgcgg acggccgccg
     7501 ccgccctcgc cgcagccttt cccccgcccg cccactggac cggacaggtc accgacgaca
     7561 ccgtcgtctg ccgctgcgag gaggtcaccg ccggcgccgt ccgggaggcc gtcgacggac
     7621 tcggcgcgga cgacgtccgc accgtcaagc tgctgacccg cgcggggatg ggatggtgcc
     7681 agggccggat gtgcgccccc gcggtcgccg gcctcaccgg ctgcgaaccc ggcccggccc
     7741 ggcgcccgtt cgcccgcccg gtgcccctcg gcgtgctggc ccggacacgg gccgaggaac
     7801 ccggagcgac ccaggaaacc gagagaggac cctcatgacc gaccaccgtc cctggcgcgg
     7861 cgtcctcgtc gccaccgcgc tgccgctgca cgaggacctc tccgtcgacc acgacgccta
     7921 cgccgagcac tgcgcctggc tggtggcgaa cggctgcgac ggcgtcgtac ccaacggctc
     7981 cctcggcgag taccaggtgc tcacccccga ggagcgcacc cgcgtcgtgg agaccgccgt
     8041 cgccgcggtc ggcggggcac gggtcgtgcc cggtgtcgcg gcctacggct gtgccgaggc
     8101 ccgccgctgg gccgagcagg cccgcgaggc cggctgcggc gcggtgatgc tgctgccgcc
     8161 caacgcctac cgtgccgacg agcggtccgt cctcgcccac tacgcggagg tggcgcgggc
     8221 gggcctgccg gtcgtcgcgt acaacaaccc cgtggacacc aaggtggacc tggtgccgga
     8281 ggtgctcgcc cggctgcacg gcgagggcca catccaggcc gtgaaggagt tctccggtga
     8341 cgtccgccgc gcctaccgcc tcgcggaact ggccccggaa ctagacctgc tggccggcgc
     8401 cgacgacgtc ctgctggagc tggcgatcgc gggtgccaag ggctggatcg ccgggtaccc
     8461 caacgcgctg cccgccgcct gcgtcgagct gtaccgtgcc gccgtcaccg gtgacctggt
     8521 cacggccggg cggctgtacc ggcagctgca cccgctgctg cgctgggact cgaaggtcga
     8581 gttcgtccag gccatcaaac actccatgga cctcgccgga cgccacggcg gcccctgccg
     8641 cccgccccgc gtcccgctgc agcccgacca ggaggccgcg gtccgcgccg ccaccgagaa
     8701 ggccctcgcg gccggactgg cgtagggagc cctcatgcgc agcagactcg tcctgcacgc
     8761 cgtcgactcg cacaccgagg gcatgcccac ccgggtggtc accggcggcg tcggcaccat
     8821 ccccggcgcg accatgaacg agcggcggct gtacttccgc gagcaccgcg acgacgtcaa
     8881 gcggctgctg atgaacgagc cgcgcggcca cgccgccatg agcggcgcga tcctccagcc
     8941 gcccacccgg cccgactgcg actggggcgt ggtctacatc gaggtctccg gctacctccc
     9001 catgtgcggc cacggcacca tcggcgtggc gaccgtcctc gtcgagaccg gcatggtcga
     9061 ggtcgtcgaa cccgtcacca ccatccgtct cgacaccccc gccggggtcg tcgtcgccga
     9121 ggtcgccgtg gagggcggcg ccgcccgcgc ggtgaccctg cgcaacgtcc cctccttcgc
     9181 cgccggcctc gaccgcgagg tcaccctgcc cgacggccgg accgtgaggt acgacctcgc
     9241 ctacggcggc aacttctacg cgatcctgcc gctggagcgc ctcgggctgc ccttcgaccg
     9301 gtcccgcaag gacgagatcc tcgccgccgg cctcgccctg atggcggccg tcaacgacgc
     9361 ggaggaaccg gtccatcccg aggacccgtc catccgcggc tgccaccatg tgcaggtgac
     9421 cgcacccgac gccaccgccc gccactcccg gcacgccatg gtgatccacc ccggctggtt
     9481 cgaccgttcg ccctgcggca ccggcaccag cgcccgcatg gcccagctcc acgcccgggg
     9541 cgaactcccg ccgcacaccg agttcgtgaa cgagtccttc atcggcaccc ggttcaccgg
     9601 acggctgctc ggcaccaccg aggtcggggg ccggcccgcc gtgctgccca gtttcaccgg
     9661 ccgggcctgg atcaccggca ccgcccagta cctcctggac cccgaggacc ccttccccgc
     9721 cgggttcgtg ctgtgaacgc cggcggtccc gccctgcccg tcctcggcgg caggaagacc
     9781 agtcaccgcg agcgggtcgc cgaggcgctg cgcgccgccc tcatcgcggg cgaactgcgc
     9841 cccggcgagg tccactcggc gcccggcctc gccgcccgct tcggcgtctc cgccaccccc
     9901 gtgcgcgagg cgatgctcga cctcgcgaag gaggggctgg tcgacaccgt gcccaacaag
     9961 gggttccggg tcaccgccgt ctccgaccgg cagctcgacg agtacacgca catccggtca
    10021 ctcatcgaga tccccaccac cgccgcactc gccggcacgg ccgaccccac cgccctggag
    10081 gcactgcgcc cggtcgccga ggagatcgtc acctccgccg cggccggcga cctcatcgcg
    10141 tacgtcgagg ccgacctgcg cttccacctc gggctgctgg aactggcggg caacgcccat
    10201 ctggtggacg tcgtacggga cctgcgccgg cgctcccggc tgtacgggct gacggcgctg
    10261 gtcgagcagg ggcggctcca ggcgtccgcc gaggagcacc tggagatcct cgacgcgctg
    10321 ctcgcccgcg acgaggaggc cgtgcgcgcc gtgatgacgc ggcacctggg acacgtccgc
    10381 ggcatgtggg cggcccgcgt cggcgaggcg gcggcgcctc cgagctgacc ggctgcccgg
    10441 ccccgcgtcc caccgcccgg atctgctcgt gcacgcgggc aagcggtgct gcgcaccgcc
    10501 gcgaggccga cggacggacg acgcacgacc gcccttcagg gagggtgctc cgacgggccg
    10561 tgcgcggacg gcacgaacgt actcggcggg aacgtggggc ccgcccgggc tccgggtcaa
    10621 cgcccttgcc ggcatggatg gttgatgctt cgaccgggcg tcgttgacag tgcgggacgc
    10681 gcactcgtag cgtgcgccct gcgtacgccc gtccgtgcgg cacgcgctcg ccgagagggt
    10741 tccgcccgga ggcccgatgc ccgaagacgc agtccgcgcg ccgcacttcg tgaggtcctt
    10801 cgaacggggt ctcgccgtca tcagggcctt cgacgccgac catccggcac tcacgctgag
    10861 cgaggtcgca cgcgccgcgg aactgacccg ggcggccgcc cgccgcttcc tgctcaccct
    10921 ggccgacctc ggctacgtcc acaccgacgg ccggctgttc cggctcaccc cgcgcgtgct
    10981 ggagctcggc tactcctatc tggcgggctt caccctgccg cagatcgccg agccgcatct
    11041 ggagcgactc gtggcgcggg tacgggagtc gtcctcgctg tgcgtcctcg aaggcgacga
    11101 catcgtccac gtcgcccgcg tccctgcccg ccgcatcatg gccgcctcga tcacggtcgg
    11161 cgcccgtttc ccggcgcacc tcacctccgt gggccgggtc gtcctcgccg gtctgccgga
    11221 ggccgaggcc gaggtccgga tcgcccgcgc ggacctgcgc ccgcacaccg cccgcaccct
    11281 cacctcggcg gacgccctgc gcgcggagct gcgccgggtc cgccgccagg gctacgcact
    11341 ggtcgaccag gagctggagg acggcctcag ggccgtcgcc gcgccggtgc gggaccggga
    11401 cggcgaggtg gtggccggcg tgggcatcgc ggtgcacgcc ggccgcaact ccgtggagtc
    11461 cgtgcgccgg gacctgctgc cgcacctgct ggccacggcc gcccggatcg acgcggacct
    11521 caggatcaca ggtccggcac gaaccgccgg ccacgacggc gggacacgcg gctgagcacg
    11581 gtctcgccgt cggcccggtc cgcctcggtg agcaccgacg cacagcgcgc cccgaccgcg
    11641 cagggcgggt ggcagcggtc ctgcggctcc acgggggtgc cggacgcggt cgggtgcggc
    11701 gcgaccgggt cccgtcatcg gtgacggtgg ccgggcacca cgccggccac gccgtcccgc
    11761 ccggacaacg tgacttccgt ctgacggaac ctcctccgtc cgggatccct cccgcgaagt
    11821 tacccgtgcg ttccgcacgt cggagaggtg acagcggcaa ctgtgcgggg tcgtgggccg
    11881 cgtgacaccg tcatctccgt cagcgaccgg tggaagggag taggcgtgaa caagggctac
    11941 gccgtgtact gcgacgcgga cccgtacttc tacgacgccc cccaccgcac gtccccgcgg
    12001 accggtgccg ggcgctcccg gtacgccgcg gcctcccggc ccgtaccgga gggatggcag
    12061 cgcaacgaga gcggggactg gctcgccctg cgtccggtcg acgccgtcct gcccgaccag
    12121 ggctggaaga tccacgtcgc ggcctgtctc gacaacgccg agagcgtgct cgaccgggtg
    12181 tggcggcact gcgtcgagcg cggcacggcc ttcaagttcg tccccagccg ctacctgctg
    12241 caccagcgca acgccaagta cgcggaccgg gccggcagcg gcaagttcat caccgtgtac
    12301 ccggcggacg aggcggactt cgagcggctc gtggacgagc tgtccggcct gctgtccggc
    12361 gagcccgggc cgcacatcct gagcgacctg cggatcggcg cgggccccgt gcacgtccgg
    12421 tacggcggct tcacccgccg caactgctac gacgcgaacg gggagctgcg gccggccgtc
    12481 actggccccg acggcgtgct ggtgcccgac ctgcgcggac cggccttccg gatacccgac
    12541 tgggtgcgcc cgcccgcctt cctgcgcccg cacctcgacg cccgcgccgc ggtgaccgtg
    12601 agtggtctgc cctacgccat cgagtcggcg ctgcacttct ccaacggcgg cggtgtgtac
    12661 ctcgcccgcg acacccgcac cggcgagcag gtcgtcctca aggaggcccg tccgcacgcc
    12721 ggtctggcgg ccgacggcgc cgacgccgtc gcccggctgc accgcgaacg ccgggcgctg
    12781 gaactcctct cgggcctcga ctgcacgccc gaggtgctcg accacctcac gatcggggag
    12841 catcacttcc tcgtgctgga gcacgtcgac ggcaagccgc tcaacacgtt cttcgcccgc
    12901 cgtcacccgc tcatcgaggc cgacccggac gcgcggcgac tggccgagta caccgcctgg
    12961 gccctggagg tccacgcacg ggtggaacgc gccgtggcgg acgtccacgc ccggggcgtg
    13021 gtcttcaacg acctgcacct gttcaacatc atgatccgcg aggacgacag cgtcaccctg
    13081 ctggacttcg aggccgcgca ccacgtcgac gaacccggcc ggcagaccgt cgcgaacccc
    13141 gggttcgtgg cgccgtccga ccgacggggc gtcgcggtgg accggtacgc gctggcgtgc
    13201 ctgcggctcg cgctgttcct cccgctcacc agtctgctgg cgctcgaccg gcgcaaggcg
    13261 gcccacctcg ccgacgtgat cgcggagcag ttccccgtgg agcgttcctt cctggacgcg
    13321 gcggtcgacg agatcacggc cggtgccgac ggtgcccgcc cggagcggcg gccggccggc
    13381 ccggtggcgc cggtccggcc gcacgactgg ccccgcagcc gggaatcgat ggccgaggcc
    13441 atccgcgcat ccgcgacgcc gtcccgcacg gaccggctct tccccggcga catcgcccag
    13501 ttcgccacgg cgggcggcgg ccttgccttc ggccacgggg cggccggagt gctgtacgcc
    13561 ctggccgaga gcggggcggg acgggacgag gacggggagc agtggctgct ggagcggacc
    13621 aagcaaccgc cctcgggcat gccgcacggc ttccacgacg gcctcgcggg cctcgcctgg
    13681 accctggagc gtctcggcca ccgcgaccgc gccctcgatc tcgtcgaact cctcctcgac
    13741 cagcccttcg accacctggg tgccgacctg cacagtggca cggccggact gggcctggcc
    13801 ctcgactcgc tggccgccac caccggggag agcgcgctgc acgcggcggc cctgcgctgc
    13861 gccgagctca ccgccgccgg cacgtccgcc gggagcgagg gctccggccg gccccgcgcg
    13921 ggactgctgt acggagccgc gggacgcgcg ctgctcttcg tgcggctctt cgaacgcacc
    13981 ggggacccgt ccttcctcga cctcgcccgc gacgcgctgc gccaggacct cgcgcgctgc
    14041 gtccgcggcg cgggcggcgc gctgcaggtg gacgagggct ggcgcaccat gccctacctg
    14101 ggcgcgggca gcgtgggcat cggcatggtg ctcgacgact acctggcaca ccgggacgac
    14161 gaggagttcg cccgggcgcg gggcgagatc gtggcggcgg cgcaggccat gttctacgcc
    14221 cagccggggc tctaccgggg tgtcgccgga atggtgctcc acctcggccg gaccaccgcc
    14281 ccggtgcccg gcaccggccc ggcggccgta cggcgccagc tcgacgccct ggcctggcac
    14341 gccatgtcct accgcgaccg gctcgccttc cccggcgagc agatgatgcg cctgtccatg
    14401 gacctctcca cgggaacggc cggatgcctg ctggccgtcg cctccgtact cggcgacgag
    14461 cccgccgccc tgccgttcct gccgccgctg cccccggaca gcggcccaca gactcggccc
    14521 cgtcaggggt cgtgaccgaa gcacacccgt tgccgtacga agggaagatg tcatgaacct
    14581 gtttgacctg cagtcgatgg agacccccaa ggaagaggcc atgggggacg tcgagaccgg
    14641 aagccgcgcg agcctgctgc tctgcggcga cagcagcctg agcatcacca cctgtaactg
    14701 acacgggtgt tgaccgccgc ggtggcgtgg tgagccacgt cgcccggtga cggcgccccg
    14761 ggatctcccg gggcgccgac gcctgcgcgc aggaacgacc cggccgcacg ccccaccggc
    14821 gggcgaccgg tgtcccggcg cgacgggacg aacggaaggg gcttggggcc ggtggcggag
    14881 acgagacccc gcaagcgacg gccgccctcc gcgcgggacg cggccgaccg cgcgaagcgg
    14941 gggcgggggc tcgaagcgct cgtgctgtcg tgctcggtcg cggcggccgt ggcggcggtg
    15001 gcccagcccg tggtcctcgg ccggacactg gacctgctgc tgcgcgacgg cgacgccgga
    15061 cgctggctgg ccctgagcgc cgcgctgctc gtcggcgagc tgctgttcga ctgcctgacc
    15121 tcgctgttca ccggccgttg caacgccgcg cggacggcgt ccgtgcgccg cggggccctc
    15181 gccggactgc tgcgcgccgt acccgaccgg gcacgcgccc ggacacccgg ggacgtgggc
    15241 acccgcctga ccctcaacgc cgccgacgcg ggaggcgccc ccgctgccaa ggcgtcactg
    15301 gcggcctcgc tcgtcacccc gctgggcgcg ctcgcggcgc tggccttcgt cgacctgtgg
    15361 gtgacggcgt gcgtcctggc cggactgccc gccctggcgc tggtgctgcg ggccttcgcc
    15421 cgggacaccg gcgcgtcggt cgccgcctac cagcgcaccc aggcccggat cgcgtcgcgg
    15481 ctgctggaga ccctggaggg cacggcgacg atcaccgccg cggggaccgc cgcccgggaa
    15541 cgcgcgcggg tgctggcccc gctcgccgaa ctcgctggac agggacggca gatgtgggcc
    15601 ctgcacggac gggccctcgc caggagcggc gtcctggtcc cgctgctgac cctggccgcg
    15661 acggccgtcg gcgggctgcg cctggcgtcc ggcgacctga gcgtggggga catgctcgcc
    15721 gcctgccggt acgcgcagct ggccgccggc gtcggaggga ccgcctccct gctgggcgcg
    15781 gtcgtacgcg gccgcgaggc ccggcgccgg accctggagc tggaggagat gccgcccttg
    15841 gcccacgggg cgttccgtct gcccccggac ggtccgggcg ggctcgaact gcgcggtgta
    15901 cgtgtggtgc gcgacggcag ggaggtcctg cgggccgacg gagtgcgggt gccgggcggc
    15961 accacggtcg cggtggtcgg ccgcagcggg tcggggaagt ccgtcctggc cgccgtggcg
    16021 gggcggctcg tcgaccccga cgaggggcat gtgctgctgg acggtgtccg cctcgaccgg
    16081 ctgacccgcc aggagctgcg caccgaggtc gccttcgcct tcgagcgccc ggagctgggg
    16141 gagggcacgg tcgccgaggt gatcgccgcc ggggcgcggc gggcctcgcc cgagcaggtc
    16201 cggcaggcgg ctcacgccgc gggcgccgac ggcttcgtac gccggcttcc gcgcggatac
    16261 gacaccccct tggcgtcggc gccgctctcg ggcggggagc gtcagcgtct cgggctggca
    16321 cgggcgttcg cgcacgccgg gcggctgctg gtcatggacg acgccacctc cagcctggac
    16381 accgccacgg agcacgaggt cgaccgcgcc ctgcgccgct cggtgcggcc cgggacccgc
    16441 ctggtggtcg cgcaccgcca gtccgtcgcg ggccgggcgg atctggtgct ctggctggag
    16501 gacgggtgcg tgcgggccgt cgggacacac cgggaactgt gggagctgcc cggttaccgc
    16561 gcggtcttcg ccaccggcgg caccggcccc gcagcggcat gcgaaacccc cgccgccccg
    16621 cggcccgagg aggtacggcc atgacagcgg ccgggtacca cggagcagcg tccccggagg
    16681 ccggcgggcc cggcgggtcc cgggacggcg agtccggggg gttccgggac ggcgagtccg
    16741 gggggttccg ggaccgtggg tcccggggcg gcaagcccgg tgggttccgg gacgagggct
    16801 cgcgcggatg ccgggacgac ggggccggca cgctgcgtcg cgtcgcgccg tcggcccgtc
    16861 gcttcctcgg tcgccgcaaa ggggtcctgg tacggctcgc gctgtggtcg ctggccgagt
    16921 cggggcaggc cttcctggtc ggatacgggg tggcccacgc cgtcgacgcg ttcctcgccg
    16981 gggacacccg ccgcggcctg ctgtggctcg cggtggccct ggtcgccgtg ctctccggcg
    17041 ctccggtcgt ccggggggtg ttcgcgcagc tcgccggatt gacggagccg ttgcgcgacg
    17101 gcctggtgcg ccacgcggtg gaccggtcca tggcccgggc ggcggcgacc ggctccggcg
    17161 ggacggaccg cgcggccgtc tcccggctga cgaaccaggt cgagatcgcc cgggacagct
    17221 tcgccggtct cgtcctcacc ctgcggtcct tcgtcttcac cgcggccgga gcgctgctcg
    17281 gcctgctgtc cctggccccg gccctgctcg tggtcgtgct gccgccgctg gcgggcggtc
    17341 tggcgctgtt cctggtgacg ctgcggccca tggcggcggc gcagcggcgc gccctggcgg
    17401 ccgatgaggc gctgggcgac cacgcggcgc ggtcccgggc ggcgctgcgg gacctcacgg
    17461 cctgcgggac cggacccgag gcggagcggc gcggcgggga actggtcgac gacgccgccg
    17521 ccgcggcccg gctcctggcg ggctgggcgg cggtgcgcac ggcggcgctc ggtgtcgcgg
    17581 gccacctgcc cgtgctggcg ctgctggcgg cggtgccgtg gctgcgcggg cgaggggtgt
    17641 cggcgggcgt gctgctcggc gcgttcacct acctcgtcca gtccctgctg ccggccctgc
    17701 acacgctgat gaccgcgctg gggacggcgg gggcccggct gctcgtcgtc ctcgaccgga
    17761 tcctcggccc ggattccgcg ccggtgccga tgccggagcg ggatccggtg ccggtgccgg
    17821 tgccggcggc cagggacggc gttcggccga cacccgcaag tccggccgcg gtcggcgcgg
    17881 accgcgcagg cggcgcggac cggacaggcg gcgcggaccg gacaggcggc gcggaccgga
    17941 caggcggcgc ggaccggaca ggcggcacag accccctcgg cggccggccc gccgacgtcc
    18001 ggctgccggc cggcgacgcg caccgggcgt ccggccggcc cgccgccgcg gtggagttgc
    18061 gctccgtcac cctctcctac ggcgtccggg cggaaccggt tctcgactcc ctcgacctga
    18121 acgtcgcccc cggtgaacac ctcgccgtcg tgggaccgag cggcatcggc aagtcgacgc
    18181 tcacccgcct gatcgcgggc acgctcgcgc ccagcggcgg cgaggtacgg gtggccgggc
    18241 gtcccgtcac cggccggccc accgccgaac tggccgccct tcgggtgctc gtcccgcagg
    18301 aggcctacgt cttctccggc accgtcggcg agaacatcgc gtacctgcgc ccggacgcgt
    18361 gccgggcgga actcgacgcc gccgcccggg tgctcggcct gcgcccgctg atcgagcgcc
    18421 tcggcgggct cgacgcaccg gtgcgccccg ccgaactgac ccacggggaa cggcagctcg
    18481 tggcactgac ccgcgcgtac ctgtcgcccg cgcccctgct cctgctcgac gaggccacct
    18541 gccacctcga cccggcgtcc gaggcacggg cggaggaggc cctcgcacgg cggccgggaa
    18601 ccgtgctggt ggtggcgcac cggctgtcct cggcggtccg ggccgaccgg gtgctcgtcc
    18661 tggacggcgt ggaggcggtg tgcggcacgc acgaggagct cctggaccgt tcacctctct
    18721 accgcgacct cacgggtcac tggcacgcgg gcccgctcgg acaggcctga cgccgcccgc
    18781 cgcccgccgc ccgccgcccg ccgcgtgggg cgtggccacg gccccggcac ggctcaggtc
    18841 cacccggcgc tctggacgat ccggatcgcg tccacccggt tgcgggcccc caccttccgg
    18901 atcgccgtgg ccatgtagtt gcggaccgtt ccccgggaca ggtgcagccg cgccgctatc
    18961 tcggcgatcg gcgccccctg ggcagccagg gagagcacgc tcagctcgcg ggtcgtcagg
    19021 ggcatctccg caccctgcag cagcgccacg gtgagcgtct cgtcgaggaa ccgttccccc
    19081 ttggcgaccg tgtgcacggc cgtgagcagc cgttgcaccg gggcgttctt gtcgaccagc
    19141 ccgagcgcgc ccgcgtcgaa cgcccgccgg agcaccccgg gccgcctggc ggtcgtcagc
    19201 acgacgagcc ggtccccgta cgcgtcccgc aggcgcggac cgcgtacgtc acccggtgcg
    19261 tgcaggtact cgccgtccac gacacacacg tccgccggca actcctcacc ggtcggctcc
    19321 tgcgagccgg gacacaggga cgtgacctcc agcgtgtcgt cggatctgag cagttgcacc
    19381 agtgccgacc gcagcagctc ctcgtcgtgc accacaacgg tacgaaccat ctcccccacc
    19441 ctcgtcagcg gccgcctcgt ccgggcggcc ggcacccccg cgccacgggc cgtctgccct
    19501 gatccgaccc ggcggaacac ggagcgcacg cgtgtgcgag ccgcaccgca ctcaattggc
    19561 cgtcggagag ccctctcagg ggaggtgcaa gggtgtccgc ccgtggggaa caaggcggat
    19621 aacactccgg tcgggagtcc gctcgggccg tccgggttcc gacggccggc cggcaccgtc
    19681 gggcccgtcc tgccccgtgc cctggttacg gcggcccggc accccgcgcg gcgaccgcgg
    19741 ttcccggagc cggccgtccc ggagcgaaaa ctcgaacaac ctcgaacgac tcggaggagg
    19801 ccggaaacag tcgccgtcca attcggcgtg aaatgcgcct accctgcgag cagttgtacg
    19861 cgtcgccccg accggcggcg ggcgacgcgt acgaagtcgt cccgtggggg cgggtggtgg
    19921 ccccgaccgc ggcgcgcccc gtacgggcac ggccaccacc cgggccgtcc ccgtgcccgg
    19981 ggatcagcgc tccagctccc tgtgtgccgt ctccggcagc cgcaggtaca ccagcgagga
    20041 cagcaggcag agcacggcga cgtaccaggg gaagagcccg gagtggccca ggtccttgag
    20101 gagcgtgccc acgtacggtg ccgtgccgcc gaacagggcg accgtgaggg agtaggggaa
    20161 gccgatgccc gccgcccgca cccggggcgg gaagacctcc gcgttgacgg cggcgctgat
    20221 cgacgtgaag ccggtcagca ggatcatgcc cgcgcagctc acgagcagca ggacggcgaa
    20281 cgagtcgcgc agggcgtgca gcagcggcac gctcagcagc gcgaagccca caccgaagaa
    20341 cagcagcgac gggcggcggc cgaaccggtc ggagagcagc ccgccgagcg gctggagcag
    20401 cccgaagaag gccagtgaga tcgtgcccgc cagcagcgcg tccgacttct ccacgcccac
    20461 gttgagctcc gcgtacgtcg gcaggtacga cgtccaggtg tagtaggcga gggtgccgcc
    20521 cgccgtgatg ccgcagatca gcagggactc gcgcggatgg cggcgcagcg cctcgaacag
    20581 gccgggacgc gggcccttgc gctgctcggc gctgcgggtc tccgcggcgc cccggcggat
    20641 ccagaagccg accaggctga ggacggcgcc gaccacgaac gggacgcgcc acccccagcc
    20701 gttcatccgc tcctcgctca gcgtgtccac gagcaccgtc gccacaccgg acgcgacgag
    20761 ctggcccgcc gtcgtcgaga cgtactggaa gctggagaac agaccccgcc ggccgggccc
    20821 cgccgactcc accaggaagg tcgtcgaggc cgcgaactcg ccgcccaccg agaggccctg
    20881 gagcagccgg gccacgacca ggaccaccgg ggccagtaca ccggccgccg cgtaggtcgg
    20941 ggtcagcccg accagcaggc tgctgccgcc catcagcagg atggtgaccg tcagcgcggc
    21001 ccgccgcccg cgccggtcgg cgatcgcgcc catgaccagc ccgccgaccg gacgcatgaa
    21061 gaagcccacc gcgaagacgg cgaaggtcga cagcagcggc accagcgagt tctccgcgcc
    21121 ctgcgggaac acctggtcgg cgatgtaggt ggccaggaag gtgtacgcgt accagtcgta
    21181 ccactccacg gcgttgccca ccgaggcggc gagaagctgg cgtacgggcc gtcggaccgg
    21241 gggtgcttcc gtgtgcatgc ctgtcatgat cgcgaccatc cccggacgtc aggacggcca
    21301 cacctcacgt accgacgact ttcacaccgg cgccaccgaa cccttccctg acgtttgctg
    21361 ctcctggaac actcctttcg cgcgcattcc gtcatcaccc ggcaccgtcc cgccggttgt
    21421 acccccctca aggcgagagg cccttcaccc catgcccgaa gtcaaccggc gccggttcct
    21481 ccaagtcgcg ggcgccacca cggcgttcag cgcgctgtcg gccagcatcg agcgggcggc
    21541 cgcactcccg gccaaccacc gctcggggac gatcgaggac gtcgagcaca tcgtcgtcct
    21601 gatgcaggag aaccgttcct tcgaccacta cttcggcaaa ctccggggcg tccgaggctt
    21661 cggcgacccg cacccggtca cgctcgacaa cggcaggtcg gtctggcacc aggcgaagga
    21721 cggcaaggag gtcctgccgt tccacccgga ggccgacgac ctcggcatgc agttcctgga
    21781 agggctgccg cacggctggt ccgacggcca ggacgcctac cacaacggca agtacgaccg
    21841 gtggctgccc gccaagggca ccacgaccat ggcgtacctg acccgcgagg acatcccctt
    21901 ccactacgcg ctcgccgaca ccttcacggt ctgcgacgcc taccactgct ccttcatcgg
    21961 ctccaccgac cccaaccgct actacctgtg gtcggggcac acgggcaacg acggcaaggg
    22021 cggcggcccg gtcctcggca acgacgagct cggctacgac tggacgacgt accccgagcg
    22081 cctggaggct gccggggtct cctggaaggt ctaccaggac atcggcgacg gcctggacgc
    22141 ggccggttcc tggggctgga tcgacgacgc ctaccgcggc aactacggcg acaactccct
    22201 gctgtacttc aacaagtacc gcgacgcgaa gcccggcgac ccgtggtacg acaaggcccg
    22261 caccggcacc gacgcgaaga gcggcgaggg ctacttcgac cggctccgcg ccgacgtcaa
    22321 ggccggccgg ctgccgcagg tctcctggat cgccgccccg gaggccttct ccgagcactc
    22381 caactggccg tccaactacg gcgcctggta catctcccag gtactggacg cgctcacggc
    22441 cgatccggcg gtgtgggcga agaccgccct gttcatcacg tacgacgaga acgacggctt
    22501 cttcgaccac gtggtgccgc cgctgccgcc gaagtccgcc gcgcagggcc tgtccaccgt
    22561 cgacgtctcc ctggacgtct tcaagggcag cgcgaagcac cgcgagggct tctacggact
    22621 cggcccgcgc gtgcccatgc tggtcgtctc gccctggagc aagggcggct acgtctgttc
    22681 cgagaccttc gaccacacct cggtcatccg cttcatggaa cgccgcttcg gcgtccgcga
    22741 gccggggatc tccccgtggc ggcgcgcgat ctgcggtgac ctgacctccg ccttcgactt
    22801 ctcccgccac gacagccgcc cggccggcct gccggacacc gacgcctacg agccgccgga
    22861 ccgcgtgcgc caccccgact accgcccgac cccgcccgcg gacccggaca tgccccggca
    22921 ggagcgcggc ctgcgccccg cccgccccct gcggtacgcc ccgcgggtgg acggcgccgt
    22981 ggacgcggcg gccgggacgt tcaggctggc gttcgcctcc ggggccggag ccggtgccgc
    23041 cttcctcgtc acctcgggca accgcaccga cggcccctgg acctacacca cggaggccgg
    23101 caagagcatc gcggacacct ggaactccgc gtactccgcc ggctcctacg acctgacggt
    23161 gcacggcccc aacggcttcc tgcgcgtctt ccggggccgc aacaagacca ccggacccga
    23221 ggtcaccgcc cggcacgccg gcgacgacgt ccggctgacc gtgaccaaca ccggctccgg
    23281 cacggtccgg ctgcgggtcg cgaacgccta cggcggccgg cccggaaccg tcaccgtgcg
    23341 tcccggggcg acggtccacc acaccgtcga cctcgcgcgc agccgccgct ggtacgacgt
    23401 gacggtcacc tccgaggccg atcccgcctt cctgcggcgc ttcgccgggc acgtggagaa
    23461 cgggcggccc ggggtgagcg acccggcgat cgtcaccgac tgacggtcgt caccgaacgg
    23521 cggtcgtcac cgacgggagg ccgtcgccgg ccgcggtcgc cggccggcga cggtcaccgc
    23581 cgcgtccagg tgccccggct ccggttgccg gggcaccagc gtcggccccg cctgcgtcgg
    23641 ccccggcggc tcgtacggac ccggcgcgcg ccgcacggcc ggtgccggcg ccgccacccg
    23701 cgcgggggcc ggggaagcgg cgggttcagg ccgcccgggc gtcgcccggc tgagctgcac
    23761 gacaccccag gcggccagcg ccgcaccggt cagcgcgagc agcacacccc ccgcaccgcc
    23821 ccgcagccgc tcgccgagca gcgtcagccc tatcaccgcg gcggccaccg gattggccag
    23881 ggtcaccacc gccagcggag cacccagccc gccccggtag gccgtctgcg acaacagcag
    23941 tccgcccacc gcgaaggccg ccaccagcac ggccaccccg atcacctgga cgctgagcag
    24001 cgggcccgag cggtccgtgg cggcgaccgt gacggtctgg gtgagcgccg aggcgacccc
    24061 ggaggcgatg ccggaggccg tcgcgtgccg cagccccggc cgggcgccgg gccaggagag
    24121 catgccgatc agagcggccg tcacgcccga gaccgccacc gcctcggaca cgctcagcac
    24181 gtcgtcgggc gcgggcccgg acgcggtcag cagcagcgcg cccagcccga gcagggtcag
    24241 tccggtgccc cgccactcga ccgcgctcac ccgccggccc gccagccgcg cccccaacgg
    24301 caccgccgcg accagggtga gcgcaccgag cggctggacc acggtgagcg ggccgtaccg
    24361 cagggccacg acgtgcagca gcgcggccga ggcgttgagg gcgaccgccc accaccaggc
    24421 gccggacgcc agcaggcgga gcgcgccggt gccggcgctg cgcgaggcga gccgttcctg
    24481 ggcgacggcc gcggcggcgt aggcgcacgc cgagaccagg gacagcagga cggcg
//
